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  Alzheimer's Disease

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Articles published in Acta Neuropathol

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Single Articles


    March 2017
  1. SUN M, Bell W, LaClair KD, Ling JP, et al
    Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43.
    Acta Neuropathol. 2017 Mar 22. doi: 10.1007/s00401-017-1701.
    PubMed     Text format     Abstract available


  2. DRUMMOND E, Nayak S, Faustin A, Pires G, et al
    Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease.
    Acta Neuropathol. 2017 Mar 4. doi: 10.1007/s00401-017-1691.
    PubMed     Text format     Abstract available


    February 2017
  3. DEMING Y, Li Z, Kapoor M, Harari O, et al
    Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.
    Acta Neuropathol. 2017 Feb 28. doi: 10.1007/s00401-017-1685.
    PubMed     Text format     Abstract available


    January 2017
  4. ZENG J, Chen L, Wang Z, Chen Q, et al
    Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis.
    Acta Neuropathol. 2017 Jan 27. doi: 10.1007/s00401-017-1669.
    PubMed     Text format     Abstract available


    December 2016
  5. DRUMMOND E, Wisniewski T
    Alzheimer's disease: experimental models and reality.
    Acta Neuropathol. 2016 Dec 26. doi: 10.1007/s00401-016-1662.
    PubMed     Text format     Abstract available


  6. CHAPUIS J, Flaig A, Grenier-Boley B, Eysert F, et al
    Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    November 2016
  7. RAMOS-MIGUEL A, Sawada K, Jones AA, Thornton AE, et al
    Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    October 2016
  8. LACLAIR KD, Donde A, Ling JP, Jeong YH, et al
    Depletion of TDP-43 decreases fibril and plaque beta-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  9. KOSS DJ, Jones G, Cranston A, Gardner H, et al
    Soluble pre-fibrillar tau and beta-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  10. SANCHEZ-MEJIAS E, Navarro V, Jimenez S, Sanchez-Mico M, et al
    Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    September 2016
  11. HART NJ, Koronyo Y, Black KL, Koronyo-Hamaoui M, et al
    Ocular indicators of Alzheimer's: exploring disease in the retina.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  12. ANDERSEN OM, Rudolph IM, Willnow TE
    Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    August 2016
  13. KLEIN HU, Bennett DA, De Jager PL
    The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    July 2016
  14. GU BJ, Huang X, Ou A, Rembach A, et al
    Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    May 2016
  15. SHINOHARA M, Murray ME, Frank RD, Shinohara M, et al
    Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    April 2016
  16. KALARIA RN
    Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  17. MONTAGNE A, Nation DA, Pa J, Sweeney MD, et al
    Brain imaging of neurovascular dysfunction in Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  18. KUMAR S, Wirths O, Stuber K, Wunderlich P, et al
    Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.
    Acta Neuropathol. 2016;131:525-37.
    PubMed     Text format     Abstract available


    March 2016
  19. VERHEIJEN J, Van den Bossche T, van der Zee J, Engelborghs S, et al
    A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  20. SADLEIR KR, Kandalepas PC, Buggia-Prevot V, Nicholson DA, et al
    Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Abeta generation in Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  21. MERLINI M, Wanner D, Nitsch RM
    Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    January 2016
  22. JOSEPHS KA, Murray ME, Whitwell JL, Tosakulwong N, et al
    Updated TDP-43 in Alzheimer's disease staging scheme.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  23. PICCIO L, Deming Y, Del-Aguila JL, Ghezzi L, et al
    Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  24. ZOU C, Shi Y, Ohli J, Schuller U, et al
    Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  25. EISELE YS, Duyckaerts C
    Propagation of Ass pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.
    Acta Neuropathol. 2016;131:5-25.
    PubMed     Text format     Abstract available


  26. MCKEE AC, Cairns NJ, Dickson DW, Folkerth RD, et al
    The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.
    Acta Neuropathol. 2016;131:75-86.
    PubMed     Text format     Abstract available


    December 2015
  27. TOLEDO JB, Gopal P, Raible K, Irwin DJ, et al
    Pathological alpha-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  28. LOVE S, Miners JS
    Cerebrovascular disease in ageing and Alzheimer's disease.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  29. ST-AMOUR I, Cicchetti F, Calon F
    Immunotherapies in Alzheimer's disease: Too much, too little, too late or off-target?
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


    November 2015
  30. FOL R, Braudeau J, Ludewig S, Abel T, et al
    Viral gene transfer of APPsalpha rescues synaptic failure in an Alzheimer's disease mouse model.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


    October 2015
  31. WONG H, Levenga J, Cain P, Rothermel B, et al
    RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  32. BOUTER Y, Noguerola JS, Tucholla P, Crespi GA, et al
    Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  33. XIANG Y, Bu XL, Liu YH, Zhu C, et al
    Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer's disease.
    Acta Neuropathol. 2015;130:487-99.
    PubMed     Text format     Abstract available


    August 2015
  34. ARENDT T, Bruckner MK, Losche A
    Regional mosaic genomic heterogeneity in the elderly and in Alzheimer's disease as a correlate of neuronal vulnerability.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


    July 2015
  35. DOROSTKAR MM, Zou C, Blazquez-Llorca L, Herms J, et al
    Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities.
    Acta Neuropathol. 2015;130:1-19.
    PubMed     Text format     Abstract available


    April 2015
  36. ZOU C, Montagna E, Shi Y, Peters F, et al
    Intraneuronal APP and extracellular Abeta independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


    March 2015
  37. WELLER RO, Hawkes CA, Carare RO, Hardy J, et al
    Does the difference between PART and Alzheimer's disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Abeta and propagation of tau?
    Acta Neuropathol. 2015.
    PubMed     Text format    


  38. JELLINGER KA, Alafuzoff I, Attems J, Beach TG, et al
    PART, a distinct tauopathy, different from classical sporadic Alzheimer disease.
    Acta Neuropathol. 2015.
    PubMed     Text format    


  39. WALKER L, McAleese KE, Thomas AJ, Johnson M, et al
    Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


    February 2015
  40. ADORI C, Gluck L, Barde S, Yoshitake T, et al
    Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  41. HARTLAGE-RUBSAMEN M, Waniek A, Meissner J, Morawski M, et al
    Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


    January 2015
  42. LIU AK, Chang RC, Pearce RK, Gentleman SM, et al
    Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  43. DUYCKAERTS C, Braak H, Brion JP, Buee L, et al
    PART is part of Alzheimer disease.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  44. VAN LEEUWEN LA, Hoozemans JJ
    Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  45. VIOLA KL, Klein WL
    Amyloid beta oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  46. THAL DR, Fandrich M
    Protein aggregation in Alzheimer's disease: Abeta and tau and their potential roles in the pathogenesis of AD.
    Acta Neuropathol. 2015.
    PubMed     Text format    


  47. PERIC A, Annaert W
    Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  48. NHAN HS, Chiang K, Koo EH
    The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes.
    Acta Neuropathol. 2015;129:1-19.
    PubMed     Text format     Abstract available


    December 2014
  49. BOLUDA S, Iba M, Zhang B, Raible KM, et al
    Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains.
    Acta Neuropathol. 2014.
    PubMed     Text format     Abstract available


  50. THAL DR, Walter J, Saido TC, Fandrich M, et al
    Neuropathology and biochemistry of Abeta and its aggregates in Alzheimer's disease.
    Acta Neuropathol. 2014.
    PubMed     Text format     Abstract available


    October 2014
  51. FRITSCHI SK, Cintron A, Ye L, Mahler J, et al
    Abeta seeds resist inactivation by formaldehyde.
    Acta Neuropathol. 2014;128:477-84.
    PubMed     Text format     Abstract available


  52. BOLUDA S, Toledo JB, Irwin DJ, Raible KM, et al
    A comparison of Abeta amyloid pathology staging systems and correlation with clinical diagnosis.
    Acta Neuropathol. 2014;128:543-50.
    PubMed     Text format     Abstract available


    May 2014
  53. TOLEDO JB, Da X, Weiner MW, Wolk DA, et al
    CSF Apo-E levels associate with cognitive decline and MRI changes.
    Acta Neuropathol. 2014;127:621-32.
    PubMed     Text format     Abstract available


    April 2014
  54. NUBER S, Tadros D, Fields J, Overk CR, et al
    Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.
    Acta Neuropathol. 2014;127:477-94.
    PubMed     Text format     Abstract available


  55. BRAWEK B, Schwendele B, Riester K, Kohsaka S, et al
    Impairment of in vivo calcium signaling in amyloid plaque-associated microglia.
    Acta Neuropathol. 2014;127:495-505.
    PubMed     Text format     Abstract available


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