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  Alzheimer's Disease

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Articles published in J Neurosci

Retrieve available abstracts of 57 articles:
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    February 2017
  1. YE X, Feng T, Tammineni P, Chang Q, et al
    Regulation of Synaptic Abeta Generation Through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2017 Feb 3. pii: 2851-16. doi: 10.1523/JNEUROSCI.2851-16.2017.
    PubMed     Text format     Abstract available


    January 2017
  2. ZHANG ZH, Wu QY, Zheng R, Chen C, et al
    Selenomethionine mitigates cognitive decline by targeting both tau hyperphosphorylation and autophagic clearance in an Alzheimer's disease mouse model.
    J Neurosci. 2017 Jan 30. pii: 3229-16. doi: 10.1523/JNEUROSCI.3229-16.2017.
    PubMed     Text format     Abstract available


  3. JAY TR, Hirsch AM, Broihier ML, Miller CM, et al
    Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2017;37:637-647.
    PubMed     Text format     Abstract available


  4. VIEIRA MN, Beckman D
    Training Microglia to Resist Alzheimer's Disease.
    J Neurosci. 2017;37:477-479.
    PubMed     Text format    


  5. DATTA D
    APP Modulates Abeta-Induced Activation of Microglia in Mouse Model of Alzheimer's Disease.
    J Neurosci. 2017;37:238-240.
    PubMed     Text format    


  6. YANG T, Li S, Xu H, Walsh DM, et al
    Large Soluble Oligomers of Amyloid beta-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate.
    J Neurosci. 2017;37:152-163.
    PubMed     Text format     Abstract available


    December 2016
  7. PRIETO GA, Trieu BH, Dang CT, Bilousova T, et al
    Pharmacological rescue of long-term potentiation in Alzheimer diseased synapses.
    J Neurosci. 2016 Dec 16. pii: 2774.
    PubMed     Text format     Abstract available


  8. JAY TR, Hirsch AM, Broihier ML, Miller CM, et al
    Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease.
    J Neurosci. 2016 Dec 9. pii: 2110.
    PubMed     Text format     Abstract available


    November 2016
  9. LEDO JH, Azevedo EP, Beckman D, Ribeiro FC, et al
    Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-beta Oligomers in Mice.
    J Neurosci. 2016;36:12106-12116.
    PubMed     Text format     Abstract available


  10. SHI XD, Sun K, Hu R, Liu XY, et al
    Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2016;36:11959-11973.
    PubMed     Text format     Abstract available


  11. ZHANG H, Sun S, Wu L, Pchitskaya E, et al
    Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.
    J Neurosci. 2016;36:11837-11850.
    PubMed     Text format     Abstract available


    October 2016
  12. SHU S, Zhu H, Tang N, Chen W, et al
    Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1.
    J Neurosci. 2016;36:10843-10852.
    PubMed     Text format     Abstract available


    September 2016
  13. SAITO T, Matsuba Y, Yamazaki N, Hashimoto S, et al
    Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.
    J Neurosci. 2016;36:9933-6.
    PubMed     Text format     Abstract available


    August 2016
  14. DINKINS MB, Enasko J, Hernandez C, Wang G, et al
    Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse.
    J Neurosci. 2016;36:8653-67.
    PubMed     Text format     Abstract available


  15. MANOCHA GD, Floden AM, Rausch K, Kulas JA, et al
    APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2016;36:8471-86.
    PubMed     Text format     Abstract available


    July 2016
  16. SPENCER B, Desplats PA, Overk CR, Valera-Martin E, et al
    Reducing Endogenous alpha-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.
    J Neurosci. 2016;36:7971-84.
    PubMed     Text format     Abstract available


    March 2016
  17. SAKAE N, Liu CC, Shinohara M, Frisch-Daiello J, et al
    ABCA7 Deficiency Accelerates Amyloid-beta Generation and Alzheimer's Neuronal Pathology.
    J Neurosci. 2016;36:3848-59.
    PubMed     Text format     Abstract available


  18. JAOUEN F, Gascon E
    Understanding the Role of miR-33 in Brain Lipid Metabolism: Implications for Alzheimer's Disease.
    J Neurosci. 2016;36:2558-60.
    PubMed     Text format    


    January 2016
  19. OLIVEIRA MM, Lourenco MV
    Integrated Stress Response: Connecting ApoE4 to Memory Impairment in Alzheimer's Disease.
    J Neurosci. 2016;36:1053-5.
    PubMed     Text format    


  20. MEIER S, Bell M, Lyons DN, Rodriguez-Rivera J, et al
    Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis.
    J Neurosci. 2016;36:1001-7.
    PubMed     Text format     Abstract available


  21. LIAN H, Litvinchuk A, Chiang AC, Aithmitti N, et al
    Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease.
    J Neurosci. 2016;36:577-89.
    PubMed     Text format     Abstract available


  22. YUAN P, Grutzendler J
    Attenuation of beta-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity.
    J Neurosci. 2016;36:632-41.
    PubMed     Text format     Abstract available


    December 2015
  23. FERRIER J, Bayet-Robert M, Dalmann R, El Guerrab A, et al
    Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception.
    J Neurosci. 2015;35:16418-16430.
    PubMed     Text format     Abstract available


    November 2015
  24. LIU B, Le KX, Park MA, Wang S, et al
    In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice.
    J Neurosci. 2015;35:15716-30.
    PubMed     Text format     Abstract available


  25. RAPPAPORT AN, Jacob E, Sharma V, Inberg S, et al
    Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint.
    J Neurosci. 2015;35:15568-81.
    PubMed     Text format     Abstract available


  26. OSTAPCHENKO VG, Chen M, Guzman MS, Xie YF, et al
    The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to beta-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment.
    J Neurosci. 2015;35:15157-69.
    PubMed     Text format     Abstract available


    October 2015
  27. CACCAMO A, Branca C, Talboom JS, Shaw DM, et al
    Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2015;35:14042-56.
    PubMed     Text format     Abstract available


    September 2015
  28. ZHANG H, Wu L, Pchitskaya E, Zakharova O, et al
    Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease.
    J Neurosci. 2015;35:13275-86.
    PubMed     Text format     Abstract available


  29. SEGEV Y, Barrera I, Ounallah-Saad H, Wibrand K, et al
    PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE epsilon4 Human Replacement Mice.
    J Neurosci. 2015;35:12986-93.
    PubMed     Text format     Abstract available


  30. PROULX E, Fraser P, McLaurin J, Lambe EK, et al
    Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease.
    J Neurosci. 2015;35:12779-91.
    PubMed     Text format     Abstract available


  31. GILLEBERT CR, Schaeverbeke J, Bastin C, Neyens V, et al
    3D Shape Perception in Posterior Cortical Atrophy: A Visual Neuroscience Perspective.
    J Neurosci. 2015;35:12673-92.
    PubMed     Text format     Abstract available


    August 2015
  32. GONTIER G, George C, Chaker Z, Holzenberger M, et al
    Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-beta Clearance.
    J Neurosci. 2015;35:11500-13.
    PubMed     Text format     Abstract available


  33. SHAW JL, Zhang S, Chang KT
    Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome.
    J Neurosci. 2015;35:11374-83.
    PubMed     Text format     Abstract available


  34. MEGILL A, Tran T, Eldred K, Lee NJ, et al
    Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2015;35:11346-57.
    PubMed     Text format     Abstract available


    July 2015
  35. BESSON FL, La Joie R, Doeuvre L, Gaubert M, et al
    Cognitive and Brain Profiles Associated with Current Neuroimaging Biomarkers of Preclinical Alzheimer's Disease.
    J Neurosci. 2015;35:10402-11.
    PubMed     Text format     Abstract available


    June 2015
  36. HARCHA PA, Vargas A, Yi C, Koulakoff AA, et al
    Hemichannels Are Required for Amyloid beta-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice.
    J Neurosci. 2015;35:9526-38.
    PubMed     Text format     Abstract available


  37. CASALI BT, Corona AW, Mariani MM, Karlo JC, et al
    Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2015;35:9173-81.
    PubMed     Text format     Abstract available


    May 2015
  38. SEN A, Nelson TJ, Alkon DL
    ApoE4 and Abeta Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation.
    J Neurosci. 2015;35:7538-51.
    PubMed     Text format     Abstract available


    April 2015
  39. CHAKROBORTY S, Kim J, Schneider C, West AR, et al
    Nitric oxide signaling is recruited as a compensatory mechanism for sustaining synaptic plasticity in Alzheimer's disease mice.
    J Neurosci. 2015;35:6893-902.
    PubMed     Text format     Abstract available


  40. WEBSTER SJ, Van Eldik LJ, Watterson DM, Bachstetter AD, et al
    Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment.
    J Neurosci. 2015;35:6554-69.
    PubMed     Text format     Abstract available


  41. SAVAGE JC, Jay T, Goduni E, Quigley C, et al
    Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.
    J Neurosci. 2015;35:6532-43.
    PubMed     Text format     Abstract available


  42. HALL AM, Throesch BT, Buckingham SC, Markwardt SJ, et al
    Tau-dependent kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease.
    J Neurosci. 2015;35:6221-30.
    PubMed     Text format     Abstract available


  43. KAN MJ, Lee JE, Wilson JG, Everhart AL, et al
    Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.
    J Neurosci. 2015;35:5969-82.
    PubMed     Text format     Abstract available


    March 2015
  44. CASTILLO-CARRANZA DL, Guerrero-Munoz MJ, Sengupta U, Hernandez C, et al
    Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model.
    J Neurosci. 2015;35:4857-68.
    PubMed     Text format     Abstract available


    February 2015

  45. Retraction: Winton et al., Intraneuronal APP, Not Free Abeta Peptides in 3xTg-AD Mice: Implications for Tau Versus Abeta-Mediated Alzheimer Neurodegeneration.
    J Neurosci. 2015;35:3724.
    PubMed     Text format    


  46. RYAN TM, Roberts BR, McColl G, Hare DJ, et al
    Stabilization of nontoxic abeta-oligomers: insights into the mechanism of action of hydroxyquinolines in Alzheimer's disease.
    J Neurosci. 2015;35:2871-84.
    PubMed     Text format     Abstract available


  47. BEN HAIM L, Ceyzeriat K, Carrillo-de Sauvage MA, Aubry F, et al
    The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases.
    J Neurosci. 2015;35:2817-29.
    PubMed     Text format     Abstract available


  48. JUSTICE NJ, Huang L, Tian JB, Cole A, et al
    Posttraumatic stress disorder-like induction elevates beta-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses.
    J Neurosci. 2015;35:2612-23.
    PubMed     Text format     Abstract available


    January 2015
  49. SPILSBURY A, Miwa S, Attems J, Saretzki G, et al
    The Role of Telomerase Protein TERT in Alzheimer's Disease and in Tau-Related Pathology In Vitro.
    J Neurosci. 2015;35:1659-74.
    PubMed     Text format     Abstract available


  50. GEFEN T, Peterson M, Papastefan ST, Martersteck A, et al
    Morphometric and histologic substrates of cingulate integrity in elders with exceptional memory capacity.
    J Neurosci. 2015;35:1781-91.
    PubMed     Text format     Abstract available


  51. MAY PC, Willis BA, Lowe SL, Dean RA, et al
    The potent BACE1 inhibitor LY2886721 elicits robust central Abeta pharmacodynamic responses in mice, dogs, and humans.
    J Neurosci. 2015;35:1199-210.
    PubMed     Text format     Abstract available


    December 2014
  52. MURRAY ME, Przybelski SA, Lesnick TG, Liesinger AM, et al
    Early Alzheimer's Disease Neuropathology Detected by Proton MR Spectroscopy.
    J Neurosci. 2014;34:16247-55.
    PubMed     Text format     Abstract available


  53. HSIAO YH, Hung HC, Chen SH, Gean PW, et al
    Social Interaction Rescues Memory Deficit in an Animal Model of Alzheimer's Disease by Increasing BDNF-Dependent Hippocampal Neurogenesis.
    J Neurosci. 2014;34:16207-19.
    PubMed     Text format     Abstract available


    November 2014
  54. ZHANG J, Hu M, Teng Z, Tang YP, et al
    Synaptic and Cognitive Improvements by Inhibition of 2-AG Metabolism Are through Upregulation of MicroRNA-188-3p in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2014;34:14919-33.
    PubMed     Text format     Abstract available


    October 2014
  55. SHI Q, Ge Y, Sharoar MG, He W, et al
    Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition.
    J Neurosci. 2014;34:13954-62.
    PubMed     Text format     Abstract available


    September 2014
  56. LEE S, Xu G, Jay TR, Bhatta S, et al
    Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway.
    J Neurosci. 2014;34:12538-46.
    PubMed     Text format     Abstract available


  57. MA T, Chen Y, Vingtdeux V, Zhao H, et al
    Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid beta.
    J Neurosci. 2014;34:12230-8.
    PubMed     Text format     Abstract available


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