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Alzheimer's Disease

Free Subscription Articles published in J Biol Chem Retrieve available abstracts of 76 articles: HTML format Text format

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March 2010
1. DEMURO A , Parker I, Stutzmann GE
   Calcium signaling and amyloid toxicity in Alzheimer's disease.
   J Biol Chem. 2010.
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   February 2010
2. VENKATARAMANI V , Rossner C, Iffland L, Schweyer S, et al
   The histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the Alzheimer amyloid precursor protein.
   J Biol Chem. 2010.
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   January 2010
3. MBEFO MK , Paleologou KE, Boucharaba A, Oueslati A, et al
   Phosphorylation of synucleins by members of the Polo-like kinase family.
   J Biol Chem. 2010;285:2807-22.
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   December 2009
4. SINGH V , Aballay A
   Regulation of DAF-16-mediated Innate Immunity in Caenorhabditis elegans.
   J Biol Chem. 2009;284:35580-7.
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   November 2009
5. BASI GS , Feinberg H, Oshidari F, Anderson J, et al
   Structural correlates of antibodies associated with acute reversal of A-beta related behavioral deficits in a mouse model of Alzheimer's disease.
   J Biol Chem. 2009.
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   October 2009
6. HATA S , Fujishige S, Araki Y, Kato N, et al
   Alcadein cleavages by APP {alpha}-and {gamma}-secretases generate small peptides p3-Alcs indicating Alzheimer disease-related {gamma}-secretase dysfunction.
   J Biol Chem. 2009.
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   September 2009
7. AKIYAMA H , Gotoh A, Shin RW, Ohashi T, et al
   A novel role for hGas7b in microtubular maintenance: Possible implication in tau-associated pathology in Alzheimer's disease.
   J Biol Chem. 2009.
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8. NOGUCHI A , Matsumura S, Dezawa M, Tada M, et al
   Isolation and characterization of patient-derived, toxic, high-mass amyloid {beta}-protein (A{beta}) assembly from Alzheimer's disease brains.
   J Biol Chem. 2009.
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   August 2009
9. NISHIDA Y , Ito S, Ohtsuki S, Yamamoto N, et al
   Depletion of vitamin E increases Abeta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease.
   J Biol Chem. 2009.
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   July 2009
10. MCCOLL G , Roberts BR, Gunn AP, Perez KA, et al
    THE Caernorhabditis elegans Abeta1-42 model of Alzheimer's disease predominantly expresses Abeta3-42.
    J Biol Chem. 2009.
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    June 2009
11. HUNG YH , Robb EL, Volitakis I, Ho M, et al
    Paradoxical condensation of copper with elevated {beta}-amyloid in lipid rafts under cellular copper deficiency conditions: Implications for Alzheimer's disease.
    J Biol Chem. 2009.
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12. MATSUDA S , Matsuda Y, D'Adamio L
    BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.
    J Biol Chem. 2009;284:15815-25.
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13. ITTNER LM , Ke YD, Gotz J
    Phosphorylated tau interacts with c-JUN N-terminal kinase (JNK) interacting protein 1 (JIP1) in Alzheimer's disease.
    J Biol Chem. 2009.
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    May 2009
14. FUTAI E , Yagishita S, Ishiura S
    Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.
    J Biol Chem. 2009;284:13013-22.
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15. LIU Y , Zhang YW, Wang X, Zhang H, et al
    Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.
    J Biol Chem. 2009;284:12145-52.
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16. LAKSHMANA MK , Yoon IS, Chen E, Bianchi E, et al
    Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.
    J Biol Chem. 2009;284:11863-72.
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17. RUDINSKIY N , Grishchuk Y, Vaslin A, Puyal J, et al
    Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration.
    J Biol Chem. 2009;284:12447-58.
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    April 2009
18. QUINTANILLA RA , Matthews-Roberson TA, Dolan PJ, Johnson GV, et al
    Caspase-cleaved tau expression results in mitochondrial dysfunction in cortical neurons. Implications for the pathogenesis of Alzheimer disease.
    J Biol Chem. 2009.
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19. PODOLY E , Shalev DE, Shenhar-Tsarfaty S, Bennett ER, et al
    The butyrylcholinesterase K variant confers structurally-derived risks for Alzheimer's pathology.
    J Biol Chem. 2009.
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    March 2009
20. HOE HS , Fu Z, Makarova A, Lee JY, et al
    The effects of amyloid precursor protein on postsynaptic composition and activity.
    J Biol Chem. 2009;284:8495-506.
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21. KIM SH , Shi Y, Hanson KA, Williams LM, et al
    Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.
    J Biol Chem. 2009;284:8083-92.
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22. ABDALLA S , Lother H, el Missiry A, Sergeev P, et al
    Dominant negative AT2 receptor oligomers induce G-protein arrest and symptoms of neurodegeneration.
    J Biol Chem. 2009;284:6566-74.
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23. WOLFE MS
    Tau mutations in neurodegenerative diseases.
    J Biol Chem. 2009;284:6021-5.
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    February 2009
24. FROST B , Ollesch J, Wille H, Diamond MI, et al
    Conformational diversity of wild-type Tau fibrils specified by templated conformation change.
    J Biol Chem. 2009;284:3546-51.
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    January 2009
25. PLACANICA L , Tarassishin L, Yang G, Peethumnongsin E, et al
    Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.
    J Biol Chem. 2009;284:2967-77.
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26. CHENG H , Vetrivel KS, Drisdel RC, Meckler X, et al
    S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
    J Biol Chem. 2009;284:1373-84.
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    December 2008
27. ZHANG L , Bukulin M, Kojro E, Roth A, et al
    Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.
    J Biol Chem. 2008;283:35507-16.
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28. SAITO Y , Sano Y, Vassar R, Gandy S, et al
    X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
    J Biol Chem. 2008;283:35763-71.
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29. VETRIVEL KS , Meckler X, Chen Y, Nguyen PD, et al
    Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.
    J Biol Chem. 2008.
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30. ABDALLA S , Lother H, El Missiry A, Langer A, et al
    Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer;s disease.
    J Biol Chem. 2008.
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31. MAKI RA , Tyurin VA, Lyon RC, Hamilton RL, et al
    Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer's disease.
    J Biol Chem. 2008.
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    November 2008
32. ONO K , Condron MM, Ho L, Wang J, et al
    Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity.
    J Biol Chem. 2008;283:32176-87.
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33. JEGANATHAN S , Hascher A, Chinnathambi S, Biernat J, et al
    Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.
    J Biol Chem. 2008;283:32066-76.
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    October 2008
34. GLABE CG
    Structural classification of toxic amyloid oligomers.
    J Biol Chem. 2008;283:29639-43.
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35. SUZUKI T , Nakaya T
    Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions.
    J Biol Chem. 2008;283:29633-7.
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36. STEINER H , Fluhrer R, Haass C
    Intramembrane proteolysis by gamma-secretase.
    J Biol Chem. 2008;283:29627-31.
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37. THINAKARAN G , Koo EH
    Amyloid precursor protein trafficking, processing, and function.
    J Biol Chem. 2008;283:29615-9.
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38. YANKNER BA , Lu T
    Amyloid beta -protein toxicity and the pathogenesis of Alzheimer's disease.
    J Biol Chem. 2008.
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39. ZHONG N , Weisgraber KH
    Understanding the association of apolipoprotein E4 with Alzheimer's disease: Clues from its structure.
    J Biol Chem. 2008.
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40. MORRISSETTE DA , Parachikova A, Green KN, Laferla FM, et al
    Relevance of transgenic mouse models to human Alzheimer disease.
    J Biol Chem. 2008.
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41. JAN A , Gokce O, Luthi-Carter R, Lashuel HA, et al
    The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.
    J Biol Chem. 2008;283:28176-89.
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42. ROYCHAUDHURI R , Yang M, Hoshi MM, Teplow DB, et al
    Amyloid beta -protein assembly and Alzheimer's disease.
    J Biol Chem. 2008.
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    September 2008
43. RUDRABHATLA P , Zheng YL, Amin ND, Kesavapany S, et al
    Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein.
    J Biol Chem. 2008;283:26737-47.
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44. LUKIW WJ , Zhao Y, Cui JG
    An NF-kB-sensitive microRNA-146a-mediated inflammatory circuit in Alzheimer's disease and in stressed human brain cells.
    J Biol Chem. 2008.
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45. FLUHRER R , Fukumori A, Martin L, Grammer G, et al
    Intramembrane proteolysis of GxGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.
    J Biol Chem. 2008.
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    August 2008
46. FRIEDLAND RP , Tedesco JM, Wilson AC, Atwood CS, et al
    Antibodies to potato virus Y bind the amyloid beta peptide: immunohistochemical and NMR studies.
    J Biol Chem. 2008;283:22550-6.
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    July 2008
47. COLE SL , Vassar R
    The role of APP processing by BACE1, the beta-secretase, in Alzheimer's disease pathophysiology.
    J Biol Chem. 2008.
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48. NEET KE , Thinakaran G
    Thematic minireview series on the molecular basis of Alzheimer's disease.
    J Biol Chem. 2008.
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49. MUSIEK ES , Brooks JD, Joo M, Brunoldi E, et al
    Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid.
    J Biol Chem. 2008;283:19927-35.
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50. TOLIA A , Horre K, De Strooper B
    Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase.
    J Biol Chem. 2008;283:19793-803.
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51. VETRIVEL KS , Zhang X, Meckler X, Cheng H, et al
    Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.
    J Biol Chem. 2008;283:19489-98.
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52. MOWRER KR , Wolfe MS
    Promotion of BACE1 mRNA alternative splicing reduces amyloid beta-peptide production.
    J Biol Chem. 2008;283:18694-701.
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53. TIMM T , Balusamy K, Li X, Biernat J, et al
    Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.
    J Biol Chem. 2008;283:18873-82.
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54. KYRIAZIS GA , Wei Z, Vandermey M, Jo DG, et al
    Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: Implications for Alzheimer's disease pathogenesis.
    J Biol Chem. 2008;.
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    June 2008
55. REYNOLDS CH , Garwood CJ, Wray S, Price C, et al
    Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases.
    J Biol Chem. 2008;283:18177-86.
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56. SHEN C , Chen Y, Liu H, Zhang K, et al
    Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase.
    J Biol Chem. 2008;283:17721-30.
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57. SHIMOJO M , Sahara N, Mizoroki T, Funamoto S, et al
    Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
    J Biol Chem. 2008;283:16488-96.
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58. HARTLEY DM , Zhao C, Speier AC, Woodard GA, et al
    Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation.
    J Biol Chem. 2008;283:16790-800.
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59. WANG H , Ghosh A, Baigude H, Yang CS, et al
    Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression.
    J Biol Chem. 2008;283:15845-52.
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    May 2008
60. IIJIMA-ANDO K , Hearn SA, Granger L, Shenton C, et al
    Overexpression of neprilysin reduces Alzheimer's amyloid-beta 42 (Abeta 42)-induced neuron loss and intraneuronal Abeta 42 deposits, but causes a reduction in CREB-mediated transcription, age-dependent axon pathology and premature death in Drosophila.
    J Biol Chem. 2008;.
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    April 2008
61. LLOVERA RE , de Tullio M, Alonso LG, Leissring MA, et al
    The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: Implications for Alzheimer's disease pathogenesis.
    J Biol Chem. 2008;.
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62. BUGGIA-PREVOT V , Sevalle J, Rossner S, Checler F, et al
    NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.
    J Biol Chem. 2008;283:10037-47.
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63. MAGDESIAN MH , Carvalho MM, Mendes FA, Saraiva LM, et al
    Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling.
    J Biol Chem. 2008;283:9359-68.
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    March 2008
64. MA QL , Yang F, Calon F, Ubeda OJ, et al
    P21-activated kinase aberrant activation and translocation in Alzheimer's disease pathogenesis.
    J Biol Chem. 2008;.
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65. MUCHOWSKI PJ , Ramsden R, Nguyen Q, Arnett EE, et al
    Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.
    J Biol Chem. 2008;283:6330-6.
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    February 2008
66. GRIMM MO , Grimm HS, Tomic I, Beyreuther K, et al
    Independent inhibition of Alzheimer's disease beta - and gamma -secretase cleavage by lowered cholesterol levels.
    J Biol Chem. 2008;.
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67. TAGUCHI H , Planque S, Nishiyama Y, Symersky J, et al
    Autoantibody-catalyzed hydrolysis of amyloid beta peptide.
    J Biol Chem. 2008;283:4714-22.
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68. ZHAO B , Yu M, Neitzel M, Marugg J, et al
    Identification of gamma-secretase inhibitor potency determinants on presenilin.
    J Biol Chem. 2008;283:2927-38.
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    January 2008
69. FONTE V , Kipp DR, Yerg J 3rd, Merin D, et al
    Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein.
    J Biol Chem. 2008;283:784-91.
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70. PAGE RM , Baumann K, Tomioka M, Perez-Revuelta BI, et al
    Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
    J Biol Chem. 2008;283:677-83.
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71. HOOK VY , Kindy M, Hook G
    Inhibitors of cathepsin B improve memory and reduce Abeta in transgenic Alzheimer's Disease mice expressing the wild-type, but not the Swedish mutant, beta -secretase APP site.
    J Biol Chem. 2008;.
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72. SONG WL , Lawson JA, Reilly D, Rokach J, et al
    Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid.
    J Biol Chem. 2008;283:6-16.
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    December 2007
73. ELLIOTT E , Tsvetkov P, Ginzburg I
    BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.
    J Biol Chem. 2007;282:37276-84.
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74. IBEN LG , Olson RE, Balanda LA, Jayachandra S, et al
    Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.
    J Biol Chem. 2007;282:36829-36.
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75. GUNZBURG MJ , Perugini MA, Howlett GJ
    Structural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein E.
    J Biol Chem. 2007;282:35831-41.
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76. SAAVEDRA L , Mohamed A, Ma V, Kar S, et al
    Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E.
    J Biol Chem. 2007;282:35722-32.
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