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  Alzheimer's Disease

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Articles published in J Biol Chem

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    October 2017
  1. BOVE-FENDERSON E, Urano R, Straub JE, Harris DA, et al
    Cellular prion protein targets amyloid-beta fibril ends via its C-terminal domain to prevent elongation.
    J Biol Chem. 2017;292:16858-16871.
    PubMed     Text format     Abstract available


  2. SAADIPOUR K, MacLean M, Pirkle S, Ali S, et al
    The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor.
    J Biol Chem. 2017;292:16594-16604.
    PubMed     Text format     Abstract available


    September 2017
  3. CARLOMAGNO Y, Chung DC, Yue M, Castanedes-Casey M, et al
    An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.
    J Biol Chem. 2017;292:15277-15286.
    PubMed     Text format     Abstract available


    August 2017
  4. SHMUEL-GALIA L, Klug Y, Porat Z, Charni M, et al
    Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.
    J Biol Chem. 2017;292:13415-13427.
    PubMed     Text format     Abstract available


    July 2017
  5. SIDDIQUI SS, Springer SA, Verhagen A, Sundaramurthy V, et al
    The Alzheimer's Disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.
    J Biol Chem. 2017 Jul 26. pii: jbc.M117.799346. doi: 10.1074/jbc.M117.799346.
    PubMed     Text format     Abstract available


  6. ZEMPEL H, Dennissen FJA, Kumar Y, Luedtke J, et al
    Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture.
    J Biol Chem. 2017;292:12192-12207.
    PubMed     Text format     Abstract available


    June 2017
  7. VARNUM MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, et al
    A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
    J Biol Chem. 2017;292:10651-10663.
    PubMed     Text format     Abstract available


  8. PIECHOTTA A, Parthier C, Kleinschmidt M, Gnoth K, et al
    Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
    J Biol Chem. 2017 Jun 16. pii: jbc.M117.777839. doi: 10.1074/jbc.M117.777839.
    PubMed     Text format     Abstract available


  9. BUSSIERE R, Lacampagne A, Reiken S, Liu X, et al
    Amyloid beta production is regulated by beta2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.
    J Biol Chem. 2017;292:10153-10168.
    PubMed     Text format     Abstract available


    May 2017
  10. HU ZW, Ma MR, Chen YX, Zhao YF, et al
    Phosphorylation at Ser8 as an intrinsic regulatory switch to regulate the morphologies and structures of Alzheimer's 40-residue beta-amyloid (Abeta40) fibrils.
    J Biol Chem. 2017;292:8846.
    PubMed     Text format    


  11. YOSHIMURA Y, Holmberg MA, Kukic P, Andersen CB, et al
    MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions.
    J Biol Chem. 2017;292:8269-8278.
    PubMed     Text format     Abstract available


  12. MORI T, Koyama N, Tan J, Segawa T, et al
    Combination Therapy with Octyl Gallate and Ferulic Acid Improves Cognition and Neurodegeneration in a Transgenic Mouse Model of Alzheimer Disease.
    J Biol Chem. 2017 May 16. pii: jbc.M116.762658. doi: 10.1074/jbc.M116.762658.
    PubMed     Text format     Abstract available


  13. SEIXAS DA SILVA GS, Melo HM, Lourenco MV, Lyra E Silva NM, et al
    Amyloid-beta oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.
    J Biol Chem. 2017;292:7395-7406.
    PubMed     Text format     Abstract available


  14. BRITO-MOREIRA J, Lourenco MV, Oliveira MM, Ribeiro FC, et al
    Interaction of amyloid-beta (Abeta) oligomers with neurexin 2alpha and neuroligin 1 mediates synapse damage and memory loss in mice.
    J Biol Chem. 2017;292:7327-7337.
    PubMed     Text format     Abstract available


    March 2017
  15. KORSHAVN KJ, Satriano C, Lin Y, Zhang R, et al
    Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-beta.
    J Biol Chem. 2017;292:4638-4650.
    PubMed     Text format     Abstract available


  16. GERBER H, Wu F, Dimitrov M, Garcia Osuna GM, et al
    Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by gamma-Secretase and Amyloid-beta Peptide Production.
    J Biol Chem. 2017;292:3751-3767.
    PubMed     Text format     Abstract available


    February 2017
  17. MASON AR, Elia LP, Finkbeiner S
    The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels.
    J Biol Chem. 2017;292:3262-3272.
    PubMed     Text format     Abstract available


  18. LUO J, Warmlander SK, Graslund A, Abrahams JP, et al
    Cross-interactions between the Alzheimer disease amyloid-beta peptide and other amyloid proteins. A FURTHER ASPECT OF THE AMYLOID CASCADE HYPOTHESIS.
    J Biol Chem. 2017;292:2046.
    PubMed     Text format    


  19. FENG T, Tammineni P, Agrawal C, Jeong YY, et al
    Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.
    J Biol Chem. 2017;292:1679-1690.
    PubMed     Text format     Abstract available


    January 2017
  20. BODE DC, Baker MD, Viles JH
    Ion Channel Formation by Amyloid-beta42 Oligomers but Not Amyloid-beta40 in Cellular Membranes.
    J Biol Chem. 2017;292:1404-1413.
    PubMed     Text format     Abstract available


  21. MERCER SW, Wang J, Burke R
    In vivo Modelling of the Pathogenic Effect of Copper Transporter Mutations that cause Menkes and Wilson Disease, Motor Neuropathy and Susceptibility to Alzheimer's Disease.
    J Biol Chem. 2017 Jan 24. pii: jbc.M116.756163. doi: 10.1074/jbc.M116.756163.
    PubMed     Text format     Abstract available


  22. ANO Y, Dhata A, Taniguchi Y, Hoshi A, et al
    Iso-alpha-acids, bitter components of beer, prevent inflammation and cognitive decline induced in a mouse model of Alzheimer's disease.
    J Biol Chem. 2017 Jan 13. pii: jbc.M116.763813. doi: 10.1074/jbc.M116.763813.
    PubMed     Text format     Abstract available


  23. HATAMI A, Monjazeb S, Milton S, Glabe CG, et al
    Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide.
    J Biol Chem. 2017 Jan 3. pii: jbc.M116.755264. doi: 10.1074/jbc.M116.755264.
    PubMed     Text format     Abstract available


    December 2016
  24. HU ZW, Ma MR, Chen YX, Zhao YF, et al
    Phosphorylation at Ser 8 as an Intrinsic Regulatory Switch to Regulate the Morphologies and Structures of Alzheimer's 40-residue beta-Amyloid (Abeta40) Fibrils.
    J Biol Chem. 2016 Dec 28. pii: jbc.M116.757179. doi: 10.1074/jbc.M116.757179.
    PubMed     Text format     Abstract available


    August 2016
  25. DEL PRETE D, Rice RC, Rajadhyaksha AM, D'Adamio L, et al
    Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
    J Biol Chem. 2016;291:17209-27.
    PubMed     Text format     Abstract available


    July 2016
  26. ANDREW RJ, Kellett KA, Thinakaran G, Hooper NM, et al
    A Greek Tragedy: the Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.
    J Biol Chem. 2016 Jul 29. pii: jbc.R116.746032.
    PubMed     Text format     Abstract available


    June 2016
  27. LUO J, Warmlander SK, Graslund A, Abrahams JP, et al
    Cross interactions between the Alzheimer's disease amyloid-beta peptide and other amyloid proteins: a further aspect of the amyloid cascade hypothesis.
    J Biol Chem. 2016 Jun 20. pii: jbc.R116.714576.
    PubMed     Text format     Abstract available


  28. HAAS LT, Strittmatter SM
    Oligomers of Amyloid-beta Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer's Disease.
    J Biol Chem. 2016 Jun 20. pii: jbc.M116.720664.
    PubMed     Text format     Abstract available


  29. POLANCO JC, Scicluna BJ, Hill AF, Gotz J, et al
    Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
    J Biol Chem. 2016;291:12445-66.
    PubMed     Text format     Abstract available


  30. DELGADO DA, Doherty K, Cheng Q, Kim H, et al
    Distinct Membrane Disruption Pathways Are Induced by 40-Residue beta-Amyloid Peptides.
    J Biol Chem. 2016;291:12233-44.
    PubMed     Text format     Abstract available


  31. CIFELLI JL, Dozier L, Chung TS, Patrick GN, et al
    Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons.
    J Biol Chem. 2016;291:11981-92.
    PubMed     Text format     Abstract available


    April 2016
  32. CIVITELLI L, Sandin L, Nelson E, Khattak SI, et al
    The Luminescent Oligothiophene p-FTAA Converts Toxic Abeta1-42 Species into Nontoxic Amyloid Fibers with Altered Properties.
    J Biol Chem. 2016;291:9233-43.
    PubMed     Text format     Abstract available


  33. HASHIMOTO Y, Toyama Y, Kusakari S, Nawa M, et al
    An Alzheimer's disease-linked rare mutation potentiates netrin receptor uncoordinated-5C-induced signaling that merges with amyloid beta precursor protein signaling.
    J Biol Chem. 2016 Apr 11. pii: jbc.M115.698092.
    PubMed     Text format     Abstract available


  34. LIU C, Song X, Nisbet R, Gotz J, et al
    Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease.
    J Biol Chem. 2016;291:8173-88.
    PubMed     Text format     Abstract available


  35. QI H, Prabakaran S, Cantrelle FX, Chambraud B, et al
    Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase.
    J Biol Chem. 2016;291:7742-53.
    PubMed     Text format     Abstract available


    March 2016
  36. BEEG M, Stravalaci M, Romeo M, Carra AD, et al
    Clusterin Binds to Abeta1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation.
    J Biol Chem. 2016;291:6958-66.
    PubMed     Text format     Abstract available


  37. GUNN AP, Wong BX, Johanssen T, Griffith JC, et al
    Amyloid-beta Peptide Abeta3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.
    J Biol Chem. 2016;291:6134-45.
    PubMed     Text format     Abstract available


  38. TIEN NT, Karaca I, Tamboli IY, Walter J, et al
    Trehalose alters subcellular trafficking and the metabolism of the Alzheimer-associated amyloid precursor protein.
    J Biol Chem. 2016 Mar 8. pii: jbc.M116.719286.
    PubMed     Text format     Abstract available


    February 2016
  39. JAROSZ-GRIFFITHS HH, Noble E, Rushworth JV, Hooper NM, et al
    Amyloid-beta Receptors: The Good, the Bad, and the Prion Protein.
    J Biol Chem. 2016;291:3174-83.
    PubMed     Text format     Abstract available


    January 2016
  40. MIYAMOTO T, Kim D, Knox JA, Johnson E, et al
    Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-beta-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
    J Biol Chem. 2016;291:1719-34.
    PubMed     Text format     Abstract available


  41. BARR RK, Verdile G, Wijaya LK, Morici M, et al
    Validation and Characterization of a Novel Peptide That Binds Monomeric and Aggregated beta-Amyloid and Inhibits the Formation of Neurotoxic Oligomers.
    J Biol Chem. 2016;291:547-59.
    PubMed     Text format     Abstract available


    December 2015
  42. SCHNODER L, Hao W, Qin Y, Liu S, et al
    Deficiency of Neuronal p38alpha-MAPK Attenuates Amyloid Pathology in Alzheimer's Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.
    J Biol Chem. 2015 Dec 9. pii: jbc.M115.695916.
    PubMed     Text format     Abstract available


    November 2015
  43. SPENCER B, Potkar R, Metcalf J, Trinh I, et al
    Systemic CNS-targeted Delivery of NPY Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2015 Nov 30. pii: jbc.M115.678185.
    PubMed     Text format     Abstract available


  44. FUTAI E, Osawa S, Cai T, Fujisawa T, et al
    Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate gamma-Secretase Activities.
    J Biol Chem. 2015 Nov 11. pii: jbc.M114.629287.
    PubMed     Text format     Abstract available


  45. SMILANSKY A, Dangoor L, Nakdimon I, Ben-Hail D, et al
    The voltage-dependent anion channel 1 mediates amyloid beta toxicity and represents a potential target for Alzheimer's disease therapy.
    J Biol Chem. 2015 Nov 5. pii: jbc.M115.691493.
    PubMed     Text format     Abstract available


    October 2015
  46. ATAGI Y, Liu CC, Painter MM, Chen XF, et al
    Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
    J Biol Chem. 2015;290:26043-50.
    PubMed     Text format     Abstract available


    September 2015
  47. TIWARI SK, Seth B, Agarwal S, Yadav A, et al
    Ethosuximide induces hippocampal neurogenesis and reverses cognitive deficits in amyloid-beta toxin induced Alzheimer's rat model via PI3K/Akt/Wnt/beta-catenin pathway.
    J Biol Chem. 2015 Sep 29. pii: jbc.M115.652586.
    PubMed     Text format     Abstract available


  48. PRADE E, Bittner HJ, Sarkar R, Lopez Del Amo JM, et al
    Structural mechanism of the interaction of Alzheimer's disease Abeta fibrils with the NSAID sulindac sulfide.
    J Biol Chem. 2015 Sep 28. pii: jbc.M115.675215.
    PubMed     Text format     Abstract available


  49. BARRITT JD, Viles JH
    Truncated Amyloid-beta(11-40/42) from Alzheimer's Disease Binds Copper2+ with a Femtomolar Affinity and Influences Fibre Assembly.
    J Biol Chem. 2015 Sep 25. pii: jbc.M115.684084.
    PubMed     Text format     Abstract available


  50. WANG R, Chen S, Liu Y, Diao S, et al
    All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor kappaB (NFkappaB) signaling.
    J Biol Chem. 2015;290:22532-42.
    PubMed     Text format     Abstract available


  51. ITAKURA M, Nakajima H, Kubo T, Semi Y, et al
    Glyceraldehyde-3-Phosphate Dehydrogenase Aggregates Accelerate Amyloid-beta Amyloidogenesis in Alzheimer Disease.
    J Biol Chem. 2015 Sep 10. pii: jbc.M115.669291.
    PubMed     Text format     Abstract available


    August 2015
  52. SKERRETT R, Pellegrino MP, Casali BT, Taraboanta L, et al
    Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor gamma Agonist Treatment Reduces Amyloid beta Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice.
    J Biol Chem. 2015;290:21591-602.
    PubMed     Text format     Abstract available


  53. FUNK KE, Mirbaha H, Jiang H, Holtzman DM, et al
    Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.
    J Biol Chem. 2015;290:21652-62.
    PubMed     Text format     Abstract available


  54. SATOH K, Abe-Dohmae S, Yokoyama S, St George-Hyslop P, et al
    ABCA7 Loss of Function Alters Alzheimer Amyloid Processing.
    J Biol Chem. 2015 Aug 10. pii: jbc.M115.655076.
    PubMed     Text format     Abstract available


    July 2015
  55. KIM B, Figueroa-Romero C, Pacut C, Backus C, et al
    Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485 Phosphorylation.
    J Biol Chem. 2015;290:19146-57.
    PubMed     Text format     Abstract available


  56. ZENG L, Hu C, Zhang F, Xu DC, et al
    Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced gamma-Secretase-dependent and -independent Apoptosis, Respectively.
    J Biol Chem. 2015;290:18269-80.
    PubMed     Text format     Abstract available


    May 2015
  57. CASEY CS, Atagi Y, Yamazaki Y, Shinohara M, et al
    Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway.
    J Biol Chem. 2015;290:14208-17.
    PubMed     Text format     Abstract available


  58. KOSTYLEV MA, Kaufman AC, Nygaard HB, Patel P, et al
    Prion-Protein-Interacting Amyloid-beta Oligomers of High Molecular Weight are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.
    J Biol Chem. 2015 May 27. pii: jbc.M115.643577.
    PubMed     Text format     Abstract available


  59. FU W, Shi D, Westaway D, Jhamandas JH, et al
    Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity.
    J Biol Chem. 2015;290:12504-13.
    PubMed     Text format     Abstract available


    April 2015
  60. PLANQUE SA, Nishiyama Y, Sonoda S, Lin Y, et al
    Specific amyloid beta clearance by a catalytic antibody construct.
    J Biol Chem. 2015;290:10229-41.
    PubMed     Text format     Abstract available


    March 2015
  61. CHERUVARA H, Allen-Baume VL, Kad NM, Mason JM, et al
    Intracellular screening of a peptide library to derive a potent peptide inhibitor of alpha-synuclein aggregation.
    J Biol Chem. 2015;290:7426-35.
    PubMed     Text format     Abstract available


  62. KUO IY, Hu J, Ha Y, Ehrlich BE, et al
    Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.
    J Biol Chem. 2015;290:6419-27.
    PubMed     Text format     Abstract available


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