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	The Medical Article of the Year 2008

Alzheimer's Disease

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May 2008
1. IIJIMA-ANDO K , Hearn SA, Granger L, Shenton C, et al
   Overexpression of neprilysin reduces Alzheimer's amyloid-beta 42 (Abeta 42)-induced neuron loss and intraneuronal Abeta 42 deposits, but causes a reduction in CREB-mediated transcription, age-dependent axon pathology and premature death in Drosophila.
   J Biol Chem. 2008;.
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   April 2008
2. LLOVERA RE , de Tullio M, Alonso LG, Leissring MA, et al
   The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: Implications for Alzheimer's disease pathogenesis.
   J Biol Chem. 2008;.
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3. BUGGIA-PREVOT V , Sevalle J, Rossner S, Checler F, et al
   NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.
   J Biol Chem. 2008;283:10037-47.
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4. MAGDESIAN MH , Carvalho MM, Mendes FA, Saraiva LM, et al
   Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling.
   J Biol Chem. 2008;283:9359-68.
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   March 2008
5. MA QL , Yang F, Calon F, Ubeda OJ, et al
   P21-activated kinase aberrant activation and translocation in Alzheimer's disease pathogenesis.
   J Biol Chem. 2008;.
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6. MUCHOWSKI PJ , Ramsden R, Nguyen Q, Arnett EE, et al
   Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.
   J Biol Chem. 2008;283:6330-6.
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   February 2008
7. GRIMM MO , Grimm HS, Tomic I, Beyreuther K, et al
   Independent inhibition of Alzheimer's disease beta - and gamma -secretase cleavage by lowered cholesterol levels.
   J Biol Chem. 2008;.
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8. TAGUCHI H , Planque S, Nishiyama Y, Symersky J, et al
   Autoantibody-catalyzed hydrolysis of amyloid beta peptide.
   J Biol Chem. 2008;283:4714-22.
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9. ZHAO B , Yu M, Neitzel M, Marugg J, et al
   Identification of gamma-secretase inhibitor potency determinants on presenilin.
   J Biol Chem. 2008;283:2927-38.
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   January 2008
10. FONTE V , Kipp DR, Yerg J 3rd, Merin D, et al
    Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein.
    J Biol Chem. 2008;283:784-91.
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11. PAGE RM , Baumann K, Tomioka M, Perez-Revuelta BI, et al
    Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
    J Biol Chem. 2008;283:677-83.
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12. HOOK VY , Kindy M, Hook G
    Inhibitors of cathepsin B improve memory and reduce Abeta in transgenic Alzheimer's Disease mice expressing the wild-type, but not the Swedish mutant, beta -secretase APP site.
    J Biol Chem. 2008;.
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13. SONG WL , Lawson JA, Reilly D, Rokach J, et al
    Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid.
    J Biol Chem. 2008;283:6-16.
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    December 2007
14. REN Y , Xu HW, Davey F, Taylor M, et al
    Endophilin I expression is increased in the brains of Alzheimer's disease patients.
    J Biol Chem. 2007;.
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15. ELLIOTT E , Tsvetkov P, Ginzburg I
    BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.
    J Biol Chem. 2007;282:37276-84.
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16. IBEN LG , Olson RE, Balanda LA, Jayachandra S, et al
    Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.
    J Biol Chem. 2007;282:36829-36.
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17. DONNELLY PS , Caragounis A, Du T, Laughton KM, et al
    Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer's disease amyloid-beta peptide.
    J Biol Chem. 2007;.
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18. GUNZBURG MJ , Perugini MA, Howlett GJ
    Structural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein E.
    J Biol Chem. 2007;282:35831-41.
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19. SAAVEDRA L , Mohamed A, Ma V, Kar S, et al
    Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E.
    J Biol Chem. 2007;282:35722-32.
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    October 2007
20. CUMMING RC , Dargusch R, Fischer WH, Schubert D, et al
    Increase in expression levels and resistance to sulfhydryl oxidation of peroxiredoxin isoforms in amyloid beta-resistant nerve cells.
    J Biol Chem. 2007;282:30523-34.
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21. CAO D , Lu H, Lewis TL, Li L, et al
    Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer's disease.
    J Biol Chem. 2007;.
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22. HE W , Shi Q, Hu X, Yan R, et al
    The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1.
    J Biol Chem. 2007;282:29144-51.
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    September 2007
23. RYOO SR , Jeong HK, Radnaabazar C, Yoo JJ, et al
    DYRK1A-mediated hyperphosphorylation of Tau: A functional link between Down syndrome and Alzheimer's disease.
    J Biol Chem. 2007;.
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    August 2007
24. IM H , Manolopoulou M, Malito E, Shen Y, et al
    Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.
    J Biol Chem. 2007;282:25453-63.
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25. CZIRR E , Leuchtenberger S, Dorner-Ciossek C, Schneider A, et al
    Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.
    J Biol Chem. 2007;282:24504-13.
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26. GONI-OLIVER P , Lucas JJ, Avila J, Hernandez F, et al
    N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation.
    J Biol Chem. 2007;282:22406-13.
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    July 2007
27. MCCONLOGUE L , Buttini M, Anderson JP, Brigham EF, et al
    Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice.
    J Biol Chem. 2007;.
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28. UCHIDA Y , Nakano S, Gomi F, Takahashi H, et al
    Differential regulation of basic helix-loop-helix factors Mash1 and Olig2 by beta-amyloid accelerates both differentiation and death of cultured neural stem/progenitor cells.
    J Biol Chem. 2007;282:19700-9.
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    June 2007
29. TAMPELLINI D , Magrane J, Takahashi RH, Li F, et al
    Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.
    J Biol Chem. 2007;282:18895-906.
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30. HANGER DP , Byers HL, Wray S, Leung KY, et al
    Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.
    J Biol Chem. 2007;.
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31. YIN YI , Bassit B, Zhu L, Yang X, et al
    gamma -secretase substrate concentration modulates the abeta 42/abeta 40 ratio: Implications for Alzheimer's disease.
    J Biol Chem. 2007;.
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32. CHENG IH , Scearce-Levie K, Legleiter J, Palop JJ, et al
    Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.
    J Biol Chem. 2007;.
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33. BANDYOPADHYAY B , Li G, Yin H, Kuret J, et al
    Tau aggregation and toxicity in a cell culture model of tauopathy.
    J Biol Chem. 2007;282:16454-64.
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34. LITTERST C , Georgakopoulos A, Shioi J, Ghersi E, et al
    Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.
    J Biol Chem. 2007;282:16155-63.
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35. MELONI G , Faller P, Vasak M
    Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions.
    J Biol Chem. 2007;282:16068-78.
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    May 2007
36. UEMURA K , Kuzuya A, Shimozono Y, Aoyagi N, et al
    GSK3beta activity modifies the localization and function of presenilin 1.
    J Biol Chem. 2007;282:15823-32.
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37. KO MH , Puglielli L
    The sterol carrier protein SCP-x/pro-SCP-2 gene has transcriptional activity and regulates the Alzheimer's disease gamma -secretase.
    J Biol Chem. 2007;.
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38. NIZZARI M , Venezia V, Repetto E, Caorsi V, et al
    Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling.
    J Biol Chem. 2007;282:13833-44.
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    April 2007
39. MUKRASCH MD , von Bergen M, Biernat J, Fischer D, et al
    The "jaws" of the tau-microtubule interaction.
    J Biol Chem. 2007;282:12230-9.
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40. ADLERZ L , Holback S, Multhaup G, Iverfeldt K, et al
    IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways.
    J Biol Chem. 2007;282:10203-9.
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41. NECULA M , Kayed R, Milton S, Glabe CG, et al
    Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
    J Biol Chem. 2007;282:10311-24.
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42. HAFFNER C , Dettmer U, Weiler T, Haass C, et al
    The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex.
    J Biol Chem. 2007;282:10632-8.
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    March 2007
43. ADACHI R , Yamaguchi K, Yagi H, Sakurai K, et al
    Flow-induced alignment of amyloid protofilaments revealed by linear dichroism.
    J Biol Chem. 2007;282:8978-83.
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    February 2007
44. YUN HM , Kim S, Kim HJ, Kostenis E, et al
    The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn.
    J Biol Chem. 2007;282:5496-505.
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45. DE FELICE FG , Velasco PT, Lambert MP, Viola KL, et al
    Abeta oligomers induce neuronal oxidative stress through an NMDA receptor-dependent mechanism that is blocked by the Alzheimer's drug memantine.
    J Biol Chem. 2007;.
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46. XIE Z , Dong Y, Maeda U, Xia W, et al
    RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation.
    J Biol Chem. 2007;282:4318-25.
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    January 2007
47. MORETTO N , Bolchi A, Rivetti C, Imbimbo BP, et al
    Conformation-sensitive antibodies against Alzheimer amyloid-beta by immunization with a thioredoxin-constrained B-cell epitope peptide.
    J Biol Chem. 2007;.
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48. YAMAMOTO N , Matsubara E, Maeda S, Minagawa H, et al
    A ganglioside-induced toxic soluble Abeta assembly. Its enhanced formation from Abeta bearing the Arctic mutation.
    J Biol Chem. 2007;282:2646-55.
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49. KIM M , Hersh LB, Leissring MA, Ingelsson M, et al
    Decreased catalytic activity of the insulin degrading enzyme in chromosome 10-linked Alzheimer's disease families.
    J Biol Chem. 2007;.
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    December 2006
50. PIERROT N , Santos SF, Feyt C, Morel M, et al
    Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.
    J Biol Chem. 2006;281:39907-14.
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51. KUAN YH , Gruebl T, Soba P, Eggert S, et al
    PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.
    J Biol Chem. 2006;281:40114-23.
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52. ODDO S , Vasilevko V, Caccamo A, Kitazawa M, et al
    Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
    J Biol Chem. 2006;281:39413-23.
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53. SUPNET C , Grant J, Kong H, Westaway D, et al
    Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice.
    J Biol Chem. 2006;281:38440-7.
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54. HORI Y , Hashimoto T, Wakutani Y, Urakami K, et al
    The tottori (D7N) and english (H6R) familial alzheimer's disease mutations accelerate abeta fibril formation without increasing protofibril formation.
    J Biol Chem. 2006;.
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    November 2006
55. MINOPOLI G , Stante M, Napolitano F, Telese F, et al
    Essential roles for Fe65, Alzheimer's amyloid precursor binding protein, in the cellular response to DNA damage.
    J Biol Chem. 2006;.
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    September 2006
56. ISAACS AM , Senn DB, Yuan M, Shine JP, et al
    Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium.
    J Biol Chem. 2006;281:27916-23.
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57. KELLY BL , Ferreira A
    beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.
    J Biol Chem. 2006;281:28079-89.
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58. THOMAS AV , Herl L, Spoelgen R, Hiltunen M, et al
    Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.
    J Biol Chem. 2006;281:26400-7.
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    August 2006
59. YAN P , Hu X, Song H, Yin K, et al
    Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ.
    J Biol Chem. 2006;281:24566-74.
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    July 2006
60. CHONG YH , Shin YJ, Lee EO, Kayed R, et al
    ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.
    J Biol Chem. 2006;281:20315-25.
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61. KINGHORN KJ , Crowther DC, Sharp LK, Nerelius C, et al
    Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer's disease.
    J Biol Chem. 2006;.
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62. DING H , Matthews TA, Johnson GV
    Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation.
    J Biol Chem. 2006;281:19107-14.
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    June 2006
63. HUANG SM , Mouri A, Kokubo H, Nakajima R, et al
    Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
    J Biol Chem. 2006;281:17941-51.
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64. CHEN YR , Glabe CG
    Distinct early folding and aggregation properties of alzheimer amyloid-beta peptide Abeta 40 and Abeta 42: Stable trimer or tetramer formation by Abeta 42.
    J Biol Chem. 2006;.
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65. OBREGON DF , Rezai-Zadeh K, Bai Y, Sun N, et al
    ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.
    J Biol Chem. 2006;281:16419-27.
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66. CULBERT AA , Skaper SD, Howlett DR, Evans NA, et al
    MAPKAP kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity: Relevance to neuroinflammation in a transgenic mouse model of Alzheimer's disease.
    J Biol Chem. 2006;.
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67. QIN W , Yang T, Ho L, Zhao Z, et al
    Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer's disease amyloid neuropathology by calorie restriction.
    J Biol Chem. 2006;.
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    May 2006
68. CHOI S , Kim JH, Roh EJ, Ko MJ, et al
    Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells.
    J Biol Chem. 2006;281:12722-8.
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69. GALAS MC , Dourlen P, Begard S, Ando K, et al
    The peptidyl prolyl cis/trans isomerase pin1 modulates stress-induced dephosphorylation of tau in neurons: Implication in a pathological mechanism related to Alzheimer's disease.
    J Biol Chem. 2006;.
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    April 2006
70. WHITE AR , Du T, Laughton KM, Volitakis I, et al
    Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    J Biol Chem. 2006;.
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    March 2006
71. WANG R , Wang B, He W, Zheng H, et al
    Wild-type presenilin 1 protects against Alzheimer's disease mutation-induced amyloid pathology.
    J Biol Chem. 2006;.
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    February 2006
72. LEE EB , Leng LZ, Zhang B, Kwong L, et al
    Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.
    J Biol Chem. 2006;281:4292-9.
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73. OHYAMA Y , Meaney S, Heverin M, Ekstrom L, et al
    Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes.
    J Biol Chem. 2006;281:3810-20.
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