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Articles published in J Hepatol

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Single Articles


    April 2017
  1. HIRSCHFIELD GM, Beuers U, Corpechot C, Invernizzi P, et al
    EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis.
    J Hepatol. 2017 Apr 17. pii: S0168-8278(17)30186.
    PubMed     Text format     Abstract available



  2. Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline.
    J Hepatol. 2017 Apr 13. pii: S0168-8278(17)30108.
    PubMed     Text format     Abstract available


  3. RIZVI S, Gores GJ
    Emerging Molecular Therapeutic Targets for Cholangiocarcinoma.
    J Hepatol. 2017 Apr 4. pii: S0168-8278(17)30197.
    PubMed     Text format     Abstract available


    March 2017
  4. JULICH-HAERTEL H, Urban SK, Krawczyk M, Willms A, et al
    Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma.
    J Hepatol. 2017 Mar 3. pii: S0168-8278(17)30123.
    PubMed     Text format     Abstract available


    February 2017
  5. ORNTOFT NW, Munk OL, Frisch K, Ott P, et al
    Hepatobiliary transport kinetics of the conjugated bile acid tracer 11C-CSar quantified in healthy humans and patients by Positrion Emission Tomography (PET).
    J Hepatol. 2017 Feb 26. pii: S0168-8278(17)30120.
    PubMed     Text format     Abstract available


  6. KRONES E, Eller K, Pollheimer MJ, Racedo S, et al
    NorUrsodeoxycholic Acid Ameliorates Cholemic Nephropathy in Bile Duct Ligated Mice.
    J Hepatol. 2017 Feb 24. pii: S0168-8278(17)30116.
    PubMed     Text format     Abstract available


  7. MERINO-AZPITARTE M, Lozano E, Perugorria MJ, Esparza-Baquer A, et al
    SOX17 Regulates Cholangiocyte Differentiation and Acts as a Tumor Suppressor in Cholangiocarcinoma.
    J Hepatol. 2017 Feb 22. pii: S0168-8278(17)30114.
    PubMed     Text format     Abstract available


  8. NAKAGAWA R, Muroyama R, Saeki C, Goto K, et al
    miR-425 regulates inflammatory cytokine production in CD4+ T cells via N-Ras upregulation in primary biliary cholangitis.
    J Hepatol. 2017 Feb 9. pii: S0168-8278(17)30066.
    PubMed     Text format     Abstract available


  9. GUPTA K, Li Q, Fan JJ, Fong EL, et al
    Actomyosin Contractility Drives Bile Regurgitation as an Early Response During Obstructive Cholestasis.
    J Hepatol. 2017 Feb 8. pii: S0168-8278(17)30061.
    PubMed     Text format     Abstract available


  10. VESTERHUS M, Holm A, Hov JR, Nygard S, et al
    Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis.
    J Hepatol. 2017 Feb 1. pii: S0168-8278(17)30052.
    PubMed     Text format     Abstract available


    January 2017
  11. MOEINI A, Sia D, Zhang Z, Camprecios G, et al
    Mixed hepatocellular-cholangiocarcinoma tumors: cholangiolocellular carcinoma is a distinct molecular entity.
    J Hepatol. 2017 Jan 23. pii: S0168-8278(17)30014.
    PubMed     Text format     Abstract available


  12. EKSTEEN B, Heatherington J, Oshiomogo J, Panaccione R, et al
    Retraction notice to: PS124-Efficacy and Safety of Induction Dosing of Vedolizumab for Reducing Biliary Inflammation in Primary Sclerosing Cholangitis (PSC) in Individuals with Inflammatory Bowel Disease [J Hepatol 64 (2016) S199].
    J Hepatol. 2017;66:254.
    PubMed     Text format    


    December 2016
  13. SCHWINGE D, von Haxthausen F, Quaas A, Carambia A, et al
    Dysfunction of hepatic regulatory T cells in experimental sclerosing cholangitis is related with IL-12 signaling.
    J Hepatol. 2016 Dec 10. pii: S0168-8278(16)30705.
    PubMed     Text format     Abstract available


    November 2016
  14. MONTE MJ, Alonso-Pena M, Briz O, Herraez E, et al
    ACOX2 deficiency: An inborn error of bile acid synthesis identified in an adolescent with persistent hypertransaminasemia.
    J Hepatol. 2016 Nov 21. pii: S0168-8278(16)30652.
    PubMed     Text format     Abstract available


  15. LOFFLER MW, Chandran PA, Laske K, Schroeder C, et al
    Erratum to "Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient".
    J Hepatol. 2016 Nov 15. pii: S0168-8278(16)30613.
    PubMed     Text format    


    October 2016
  16. RICKE J, Seidensticker M
    Molecular imaging and liver function assessment by hepatobiliary MRI.
    J Hepatol. 2016 Oct 8. pii: S0168-8278(16)30566.
    PubMed     Text format    


  17. SCHRUMPF E, Kummen M, Valestrand L, Greiner TU, et al
    The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation.
    J Hepatol. 2016 Oct 5. pii: S0168-8278(16)30559.
    PubMed     Text format     Abstract available


  18. FICKERT P
    Bad memories from the gut may cause nightmares for the bile ducts - "Nothing fixes a thing so intensely in the memory as the wish to forget it.": Editorial for: "Gut and liver T cells of common clonal origin are detected in primary sclerosing cholangi
    J Hepatol. 2016 Oct 1. pii: S0168-8278(16)30543.
    PubMed     Text format    


    September 2016
  19. VAQUERO J, Guedj N, Claperon A, Ho-Bouldoires TH, et al
    Epithelial-mesenchymal transition in cholangiocarcinoma: from clinical evidence to regulatory networks.
    J Hepatol. 2016 Sep 26. pii: S0168-8278(16)30537.
    PubMed     Text format     Abstract available


  20. HENRIKSEN EK, Jorgensen KK, Kaveh F, Holm K, et al
    Gut and liver T cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease.
    J Hepatol. 2016 Sep 16. pii: S0168-8278(16)30503.
    PubMed     Text format     Abstract available


  21. RAGGI C, Correnti M, Sica A, Andersen JB, et al
    Cholangiocarcinoma Stem-like Cells Shapes Tumor-initiating Niche by Regulating Associated Macrophages.
    J Hepatol. 2016 Sep 1. pii: S0168-8278(16)30472.
    PubMed     Text format     Abstract available


  22. FUCHS CD, Paumgartner G, Wahlstrom A, Schwabl P, et al
    Metabolic Preconditioning Protects BSEP/ABCB11-/- Mice against Cholestatic Liver Injury.
    J Hepatol. 2016 Sep 1. pii: S0168-8278(16)30482.
    PubMed     Text format     Abstract available


    August 2016
  23. PERUGORRIA MJ, Bujanda L, Banales JM
    More insight into the diversity of cholangiocyte ciliopathies.
    J Hepatol. 2016 Aug 31. pii: S0168-8278(16)30475.
    PubMed     Text format    


    July 2016
  24. GRAMMATIKOPOULOS T, Sambrotta M, Strautnieks S, Foskett P, et al
    Mutations in DCDC2 (doublecortin domain-containing protein 2) in neonatal sclerosing cholangitis.
    J Hepatol. 2016 Jul 25. pii: S0168-8278(16)30342.
    PubMed     Text format     Abstract available


  25. LOFFLER MW, Anoop Chandran P, Laske K, Schroeder C, et al
    Personalized peptide vaccine induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient.
    J Hepatol. 2016 Jul 7. pii: S0168-8278(16)30323.
    PubMed     Text format     Abstract available


    May 2016
  26. VERKADE HJ, Bezerra JA, Davenport M, Schreiber RA, et al
    Biliary atresia and other cholestatic childhood diseases: advances and future challenges.
    J Hepatol. 2016 May 6. pii: S0168-8278(16)30186.
    PubMed     Text format    


    April 2016

  27. EASL Clinical Practice Guidelines on the prevention, diagnosis and treatment of gallstones.
    J Hepatol. 2016 Apr 11. pii: S0168-8278(16)30032.
    PubMed     Text format    


  28. WESTBROOK RH, Dusheiko G, Williamson C
    Pregnancy and liver disease.
    J Hepatol. 2016;64:933-45.
    PubMed     Text format     Abstract available


    February 2016
  29. HAN Y, Meng F, Venter J, Wu N, et al
    miR-34a-dependent overexpression of Per1 decreases cholangiocarcinoma growth.
    J Hepatol. 2016 Feb 23. pii: S0168-8278(16)00157.
    PubMed     Text format     Abstract available


  30. VAN DER WOERD WL, Wichers CG, Vestergaard AL, Andersen JP, et al
    Defective plasma membrane targeting of p.I661T-ATP8B1, associated with familial intrahepatic cholestasis, can be rescued in vitro by CFTR correctors.
    J Hepatol. 2016 Feb 12. pii: S0168-8278(16)00076.
    PubMed     Text format     Abstract available


  31. YOVCHEV MI, Locker J, Oertel M
    Biliary fibrosis drives liver repopulation and phenotype transition of transplanted hepatocytes.
    J Hepatol. 2016 Feb 5. pii: S0168-8278(16)00079.
    PubMed     Text format     Abstract available


    January 2016
  32. EKSTEEN B, Heatherington J, Oshiomogo J, Panaccione R, et al
    RETRACTED: Efficacy and Safety of Induction Dosing of Vedolizumab for Reducing Biliary Inflammation in Primary Sclerosing Cholangitis (Psc) in Individuals with Inflammatory Bowel Disease.
    J Hepatol. 2016;64.
    PubMed     Text format     Abstract available


    December 2015
  33. JEFFERY HC, van Wilgenburg B, Kurioka A, Parekh K, et al
    Bacteria Exposed Biliary Epithelium and Liver B Cells Activate Intrahepatic Mait Cells in an MR1-Dependent Manner.
    J Hepatol. 2015 Dec 29. pii: S0168-8278(15)00858.
    PubMed     Text format     Abstract available


  34. POUPON R
    ASBT inhibitors in cholangiopathies - good for mice, good for men?
    J Hepatol. 2015 Dec 18. pii: S0168-8278(15)00808.
    PubMed     Text format    


    November 2015
  35. VILGRAIN V, Van Beers BE, Pastor CM
    Insights into the diagnosis of hepatocellular carcinomas with hepatobiliary MRI.
    J Hepatol. 2015 Nov 26. pii: S0168-8278(15)00774.
    PubMed     Text format     Abstract available


    October 2015
  36. BAGHDASARYAN A, Fuchs CD, Osterreicher CH, Lemberger UJ, et al
    Inhibition of Intestinal Bile Acid Absorption Improves Cholestatic Liver and Bile Duct Injury in a Mouse Model of Sclerosing Cholangitis.
    J Hepatol. 2015 Oct 31. pii: S0168-8278(15)00723.
    PubMed     Text format     Abstract available


  37. KO S, Choi TY, Russell JO, So J, et al
    Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration.
    J Hepatol. 2015 Oct 23. pii: S0168-8278(15)00716.
    PubMed     Text format     Abstract available


  38. ACUNA M, Gonzalez-Hodar L, Amigo L, Castro J, et al
    Transgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice.
    J Hepatol. 2015 Oct 7. pii: S0168-8278(15)00669.
    PubMed     Text format     Abstract available


  39. ELFERINK RO, Paulusma CC
    MRP2 in cholestasis: Putting down the anchor.
    J Hepatol. 2015 Oct 1. pii: S0168-8278(15)00666.
    PubMed     Text format    


    September 2015
  40. BEUERS U, Gershwin ME, Gish RG, Invernizzi P, et al
    Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'.
    J Hepatol. 2015 Sep 10. pii: S0168-8278(15)00459.
    PubMed     Text format    


    August 2015
  41. DE VRIES AG, Bakker-van Waarde WM, Dassel AC, Losekoot M, et al
    A novel phenotype of a hepatocyte nuclear factor homeobox A (HNF1A) gene mutation, presenting with neonatal cholestasis.
    J Hepatol. 2015 Aug 22. pii: S0168-8278(15)00543.
    PubMed     Text format     Abstract available


  42. KAMATH PS, Poterucha JJ, Ludwig J
    Primary Biliary Cirrhosis by Another Name is Still PBC.
    J Hepatol. 2015 Aug 19. pii: S0168-8278(15)00555.
    PubMed     Text format    


  43. LEE DG, Lee SH, Kim JS, Park J, et al
    Loss of NDRG2 promotes epithelial-mesenchymal transition of gallbladder carcinoma cells through MMP-19-mediated Slug expression.
    J Hepatol. 2015 Aug 17. pii: S0168-8278(15)00548.
    PubMed     Text format     Abstract available


  44. BOSCH A, Dumortier J, Maucort-Boulch D, Scoazec JY, et al
    Preventive administration of UDCA after liver transplantation for primary biliary cirrhosis is associated with a lower risk of disease recurrence.
    J Hepatol. 2015 Aug 14. pii: S0168-8278(15)00545.
    PubMed     Text format     Abstract available


  45. LIU HX, Keane R, Sheng L, Wan YY, et al
    Implications of microbiota and bile acid in liver injury and regeneration.
    J Hepatol. 2015 Aug 6. pii: S0168-8278(15)00533.
    PubMed     Text format     Abstract available


    July 2015
  46. CHAI J, Cai SY, Liu X, Lian W, et al
    Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis.
    J Hepatol. 2015 Jul 23. pii: S0168-8278(15)00479.
    PubMed     Text format     Abstract available


  47. MENG F, Alpini G
    Peri-scoping the biliary tree reveals stem cell activation in peribiliary glands in Primary Sclerosing Cholangitis.
    J Hepatol. 2015 Jul 23. pii: S0168-8278(15)00478.
    PubMed     Text format    


  48. RAVIKUMAR R, Tsochatzis E, Jose S, Allison M, et al
    Risk Factors for Recurrent Primary Sclerosing Cholangitis After Liver Transplantation.
    J Hepatol. 2015 Jul 14. pii: S0168-8278(15)00467.
    PubMed     Text format     Abstract available


    June 2015
  49. CARPINO G, Cardinale V, Renzi A, Hov JR, et al
    Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis.
    J Hepatol. 2015 Jun 25. pii: S0168-8278(15)00410.
    PubMed     Text format     Abstract available


  50. DE VRIES EM, Verheij J, Hubscher SG, Leeflang MM, et al
    Applicability and Prognostic Value of Histologic Scoring Systems in Primary Sclerosing Cholangitis.
    J Hepatol. 2015 Jun 18. pii: S0168-8278(15)00399.
    PubMed     Text format     Abstract available


    May 2015
  51. OUT C, Patankar JV, Doktorova M, Boesjes M, et al
    Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.
    J Hepatol. 2015 May 25. pii: S0168-8278(15)00336.
    PubMed     Text format     Abstract available


  52. FARRAR CT, DePeralta DK, Day H, Rietz TA, et al
    3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model.
    J Hepatol. 2015 May 25. pii: S0168-8278(15)00335.
    PubMed     Text format     Abstract available


    April 2015
  53. BEUERS U, Trauner M, Jansen P, Poupon R, et al
    New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond.
    J Hepatol. 2015;62.
    PubMed     Text format     Abstract available


    March 2015
  54. KARIMIAN N, Weeder PD, Bomfati F, Gouw AS, et al
    Preservation Injury of the Distal Extrahepatic Bile Duct of Donor Livers Is Representative for Injury of the Intrahepatic Bile Ducts.
    J Hepatol. 2015 Mar 18. pii: S0168-8278(15)00193.
    PubMed     Text format    


  55. WIKSTROM SHEMER EA, Stephansson O, Thuresson M, Thorsell M, et al
    Intrahepatic cholestasis of pregnancy and cancer, immune-mediated and cardiovascular diseases: a population-based cohort study.
    J Hepatol. 2015 Mar 12. pii: S0168-8278(15)00177.
    PubMed     Text format     Abstract available


  56. WEEDER PD, van Rijn R, Porte RJ
    Machine perfusion in liver transplantation as a tool to prevent non-anastomotic biliary strictures: Rationale, current evidence and future directions.
    J Hepatol. 2015 Mar 11. pii: S0168-8278(15)00173.
    PubMed     Text format     Abstract available


  57. MIZUGUCHI Y, Specht S, Isse K, Sasatomi E, et al
    Breast Tumor Kinase/Protein Tyrosine Kinase 6 (Brk/PTK6) Activity in Normal and Neoplastic Biliary Epithelia.
    J Hepatol. 2015 Mar 11. pii: S0168-8278(15)00169.
    PubMed     Text format     Abstract available


    February 2015
  58. JANSEN PL, Schaap FG
    Pituitary TSH controls bile salt synthesis.
    J Hepatol. 2015 Feb 9. pii: S0168-8278(15)00077.
    PubMed     Text format    


    January 2015
  59. MUELLER M, Thorell A, Claudel T, Jha P, et al
    Ursodeoxycholic Acid Exerts Farnesoid X Receptor-antagonistic Effects on Bile Acid and Lipid Metabolism in Morbid Obesity.
    J Hepatol. 2015 Jan 21. pii: S0168-8278(15)00010.
    PubMed     Text format     Abstract available


    December 2014
  60. SONG Y, Xu C, Shao S, Liu J, et al
    Thyroid-stimulating hormone (TSH) regulates hepatic bile acid homeostasis via SREBP-2/HNF-4alpha/CYP7A1 axis.
    J Hepatol. 2014 Dec 19. pii: S0168-8278(14)00924.
    PubMed     Text format     Abstract available


  61. LEE DH, Lee JM, Lee JY, Kim SH, et al
    Non-hypervascular Hepatobiliary phase Hypointense Nodules on Gadoxetic Acid-enhanced MRI: Risk of HCC Recurrence after Radiofrequency Ablation.
    J Hepatol. 2014 Dec 18. pii: S0168-8278(14)00936.
    PubMed     Text format     Abstract available


  62. SCIVERES M, Milazzo MP, Maggiore G
    A scoring system for biliary atresia: is this the right one?
    J Hepatol. 2014 Dec 11. pii: S0168-8278(14)00922.
    PubMed     Text format    


  63. EL-GUINDI MA, Sira MM, Sira AM, Salem TA, et al
    Reply to: A scoring system for biliary atresia: is this the right one?
    J Hepatol. 2014 Dec 11. pii: S0168-8278(14)00921.
    PubMed     Text format    


    November 2014
  64. NAKANUMA Y, Sasaski M, Harada K
    Autophagy and senescence in fibrosing cholangiopathies.
    J Hepatol. 2014 Nov 27. pii: S0168-8278(14)00876.
    PubMed     Text format     Abstract available


  65. KREMER AE, Bolier R, Dixon PH, Geenes V, et al
    Autotaxin Activity has a high Accuracy to diagnose Intrahepatic Cholestasis of Pregnancy.
    J Hepatol. 2014 Nov 5. pii: S0168-8278(14)00808.
    PubMed     Text format     Abstract available


  66. KOH S, Bertoletti A
    Cancer immunotherapy: targeting the difference.
    J Hepatol. 2014;61:1175-7.
    PubMed     Text format    


    October 2014
  67. XIAO Y, Wang J, Yan W, Zhou Y, et al
    Dysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targeting IL-6/STAT3 signalling.
    J Hepatol. 2014 Oct 30. pii: S0168-8278(14)00799.
    PubMed     Text format     Abstract available


    July 2014
  68. VILARINHO S, Zeynep Erson-Omay E, Harmanci AS, Morotti R, et al
    Pediatric hepatocellular carcinoma due to somatic CTNNB1 and NFE2L2 mutations in the setting of inherited bi-allelic ABCB11 mutations.
    J Hepatol. 2014 Jul 9. pii: S0168-8278(14)00471.
    PubMed     Text format     Abstract available


    June 2014
  69. CARAMBIA A, Herkel J
    Deciphering the highway code for lymphocyte traffic along the gut - liver axis.
    J Hepatol. 2014;60:1110-1.
    PubMed     Text format    


  70. EICKMEIER I, Seidel D, Grun JR, Derkow K, et al
    Influence of CD8 T cell priming in liver and gut on the enterohepatic circulation.
    J Hepatol. 2014;60:1143-50.
    PubMed     Text format     Abstract available


  71. COULOUARN C, Clement B
    Stellate cells and the development of liver cancer: therapeutic potential of targeting the stroma.
    J Hepatol. 2014;60:1306-9.
    PubMed     Text format     Abstract available


    April 2014
  72. EHLKEN H, Schramm C
    PSC: Novel disease associations providing pathogenetic clues?
    J Hepatol. 2014;60:687-8.
    PubMed     Text format    


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