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The Medical Article of the Year 2008


  Colorectal Neoplasms

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Articles published in Br J Cancer

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    June 2008
  1. ISHIKAWA K , Kamohara Y, Tanaka F, Haraguchi N, et al
    Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer.
    Br J Cancer. 2008;98:1824-9.
    PubMed     Related articles    Abstract available


  2. LANGERS AM , Sier CF, Hawinkels LJ, Kubben FJ, et al
    MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not.
    Br J Cancer. 2008;98:1820-3.
    PubMed     Related articles    Abstract available


  3. CHEETHAM S , Tang MJ, Mesak F, Kennecke H, et al
    SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response.
    Br J Cancer. 2008;98:1810-9.
    PubMed     Related articles    Abstract available


    May 2008
  4. SHROUT J , Yousefzadeh M, Dodd A, Kirven K, et al
    beta(2)microglobulin mRNA expression levels are prognostic for lymph node metastasis in colorectal cancer patients.
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


  5. LE NH , Franken P, Fodde R
    Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness.
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


  6. KHAN OA , Ranson M, Michael M, Olver I, et al
    A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.
    Br J Cancer. 2008;98:1614-8.
    PubMed     Related articles    Abstract available


  7. BOCCI G , Falcone A, Fioravanti A, Orlandi P, et al
    Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib.
    Br J Cancer. 2008;98:1619-29.
    PubMed     Related articles    Abstract available


  8. BELOBRAJDIC DP , Cosgrove LJ, Phatak A
    Elevated serum matrix metalloproteinase 9 concentration predicts the presence of colorectal neoplasia in symptomatic patients.
    Br J Cancer. 2008;98:1593.
    PubMed     Related articles   


  9. KIM MS , Jeong EG, Yoo NJ, Lee SH, et al
    Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias.
    Br J Cancer. 2008;98:1533-5.
    PubMed     Related articles    Abstract available


  10. CALCAGNO AM , Fostel JM, To KK, Salcido CD, et al
    Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.
    Br J Cancer. 2008;98:1515-24.
    PubMed     Related articles    Abstract available   Free Full Text


    April 2008
  11. YOSHITAKE N , Fukui H, Yamagishi H, Sekikawa A, et al
    Expression of SDF-1alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer.
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


  12. CALDWELL GM , Jones CE, Soon Y, Warrack R, et al
    Reorganisation of Wnt-response pathways in colorectal tumorigenesis.
    Br J Cancer. 2008;98:1437-42.
    PubMed     Related articles    Abstract available


  13. VAREY AH , Rennel ES, Qiu Y, Bevan HS, et al
    VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy.
    Br J Cancer. 2008;98:1366-79.
    PubMed     Related articles    Abstract available


  14. KAWAKAMI K , Ooyama A, Ruszkiewicz A, Jin M, et al
    Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype.
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


  15. BRULAND O , Fluge O, Immervoll H, Balteskard L, et al
    Gene expression reveals two distinct groups of anal carcinomas with clinical implications.
    Br J Cancer. 2008;98:1264-73.
    PubMed     Related articles    Abstract available


  16. ILES S , Gollins S, Susnerwala S, Haylock B, et al
    Irinotecan+5-fluorouracil with concomitant pre-operative radiotherapy in locally advanced non-resectable rectal cancer: a phase I/II study.
    Br J Cancer. 2008;98:1210-6.
    PubMed     Related articles    Abstract available


  17. KOEBERLE D , Burkhard R, von Moos R, Winterhalder R, et al
    Phase II study of capecitabine and oxaliplatin given prior to and concurrently with preoperative pelvic radiotherapy in patients with locally advanced rectal cancer.
    Br J Cancer. 2008;98:1204-9.
    PubMed     Related articles    Abstract available


    March 2008
  18. ALLEGRINI G , Falcone A, Fioravanti A, Barletta MT, et al
    A pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients.
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


  19. PITTMAN AM , Broderick P, Sullivan K, Fielding S, et al
    CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population.
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


  20. CONAGHAN PJ , Ashraf SQ, Tytherleigh MG, Wilding JL, et al
    Targeted killing of colorectal cancer cell lines by a humanised IgG1 monoclonal antibody that binds to membrane-bound carcinoembryonic antigen.
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


  21. HIRIPI E , Bermejo JL, Sundquist J, Hemminki K, et al
    Association of colorectal adenoma with other malignancies in Swedish families.
    Br J Cancer. 2008;98:997-1000.
    PubMed     Related articles    Abstract available


  22. YAMADA Y , Tahara M, Miya T, Satoh T, et al
    Phase I/II study of oxaliplatin with oral S-1 as first-line therapy for patients with metastatic colorectal cancer.
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


    February 2008
  23. SOBHANI I , Tiret E, Lebtahi R, Aparicio T, et al
    Early detection of recurrence by (18)FDG-PET in the follow-up of patients with colorectal cancer.
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


  24. FREDERIKSEN BL , Osler M, Harling H, Jorgensen T, et al
    Social inequalities in stage at diagnosis of rectal but not in colonic cancer: a nationwide study.
    Br J Cancer. 2008;98:668-73.
    PubMed     Related articles    Abstract available


  25. MOUNIER CM , Wendum D, Greenspan E, Flejou JF, et al
    Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate.
    Br J Cancer. 2008;98:587-95.
    PubMed     Related articles    Abstract available


  26. STEBBING J , Harrison M, Glynne-Jones R, Bridgewater J, et al
    A phase II study to determine the ability of gefitinib to reverse fluoropyrimidine resistance in metastatic colorectal cancer (the INFORM study).
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


    January 2008
  27. HAMILTON W , Lancashire R, Sharp D, Peters TJ, et al
    The importance of anaemia in diagnosing colorectal cancer: a case-control study using electronic primary care records.
    Br J Cancer. 2008;98:323-7.
    PubMed     Related articles    Abstract available


  28. ZLOBEC I , Vuong T, Compton CC, Lugli A, et al
    Combined analysis of VEGF and EGFR predicts complete tumour response in rectal cancer treated with preoperative radiotherapy.
    Br J Cancer. 2008;98:450-6.
    PubMed     Related articles    Abstract available


  29. NEGRI FV , Campanini N, Camisa R, Pucci F, et al
    Biological predictive factors in rectal cancer treated with preoperative radiotherapy or radiochemotherapy.
    Br J Cancer. 2008;98:143-7.
    PubMed     Related articles    Abstract available


  30. LAGADEC P , Griessinger E, Nawrot MP, Fenouille N, et al
    Pharmacological targeting of NF-kappaB potentiates the effect of the topoisomerase inhibitor CPT-11 on colon cancer cells.
    Br J Cancer. 2008;.
    PubMed     Related articles    Abstract available


    December 2007
  31. OIKONOMOU E , Kothonidis K, Taoufik E, Probert E, et al
    Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL induced apoptosis in vitro and in vivo.
    Br J Cancer. 2007;97:1716.
    PubMed     Related articles   


  32. TIROSH B , Daniel-Carmi V, Carmon L, Paz A, et al
    '1-8 interferon inducible gene family': putative colon carcinoma-associated antigens.
    Br J Cancer. 2007;97:1655-63.
    PubMed     Related articles    Abstract available


  33. WANG X , Hershman DL, Abrams JA, Feingold D, et al
    Predictors of survival after hepatic resection among patients with colorectal liver metastasis.
    Br J Cancer. 2007;97:1606-12.
    PubMed     Related articles    Abstract available


  34. DUNCAN R , Carpenter B, Main LC, Telfer C, et al
    Characterisation and protein expression profiling of annexins in colorectal cancer.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  35. MITCHELL E , Macdonald S, Campbell NC, Weller D, et al
    Influences on pre-hospital delay in the diagnosis of colorectal cancer: a systematic review.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  36. CASCINU S , Berardi R, Salvagni S, Beretta GD, et al
    A combination of gefitinib and FOLFOX-4 as first-line treatment in advanced colorectal cancer patients. A GISCAD multicentre phase II study including a biological analysis of EGFR overexpression, amplification and NF-kB activation.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  37. KABAT GC , Miller AB, Jain M, Rohan TE, et al
    A cohort study of dietary iron and heme iron intake and risk of colorectal cancer in women.
    Br J Cancer. 2007;97:1600.
    PubMed     Related articles   


  38. SIENA S , Peeters M, Van Cutsem E, Humblet Y, et al
    Association of progression-free survival with patient-reported outcomes and survival: results from a randomised phase 3 trial of panitumumab.
    Br J Cancer. 2007;97:1469-74.
    PubMed     Related articles    Abstract available


  39. WEI LH , Baumann H, Tracy E, Wang Y, et al
    Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling.
    Br J Cancer. 2007;97:1513-22.
    PubMed     Related articles    Abstract available


    November 2007
  40. WELLER D , Coleman D, Robertson R, Butler P, et al
    The UK colorectal cancer screening pilot: results of the second round of screening in England.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  41. DAHM F , Bielawska A, Nocito A, Georgiev P, et al
    Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  42. GOBBI PG , Valentino F, Berardi E, Tronconi C, et al
    New insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  43. CRAVEN I , Crellin A, Cooper R, Melcher A, et al
    Preoperative radiotherapy combined with 5 days per week capecitabine chemotherapy in locally advanced rectal cancer.
    Br J Cancer. 2007;97:1333-7.
    PubMed     Related articles    Abstract available


  44. HUBNER RA , Liu JF, Sellick GS, Logan RF, et al
    Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma.
    Br J Cancer. 2007;97:1449-56.
    PubMed     Related articles    Abstract available


  45. HARADA K , Hiraoka S, Kato J, Horii J, et al
    Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features.
    Br J Cancer. 2007;97:1425-31.
    PubMed     Related articles    Abstract available


  46. HOFFMEISTER M , Raum E, Winter J, Chang-Claude J, et al
    Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


    October 2007
  47. SHASTRI YM , Stein JM
    New faecal tests for colorectal cancer screening: is tumour pyruvate kinase M2 one of the options?
    Br J Cancer. 2007;.
    PubMed     Related articles   


  48. HAUG U , Brenner H
    Reply: New faecal tests for colorectal cancer screening: is tumour pyruvate kinase M2 one of the options?
    Br J Cancer. 2007;.
    PubMed     Related articles   


  49. FRATTINI M , Saletti P, Romagnani E, Martin V, et al
    PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients.
    Br J Cancer. 2007;97:1139-45.
    PubMed     Related articles    Abstract available


  50. MAUGHAN NJ , Morris E, Forman D, Quirke P, et al
    The validity of the Royal College of Pathologists' colorectal cancer minimum dataset within a population.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  51. LEITCH EF , Chakrabarti M, Crozier JE, McKee RF, et al
    Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  52. HURST NG , Stocken DD, Wilson S, Keh C, et al
    Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients.
    Br J Cancer. 2007;97:971-7.
    PubMed     Related articles    Abstract available


  53. PARET C , Hildebrand D, Weitz J, Kopp-Schneider A, et al
    C4.4A as a candidate marker in the diagnosis of colorectal cancer.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


    September 2007
  54. BARONE C , Nuzzo G, Cassano A, Basso M, et al
    Final analysis of colorectal cancer patients treated with irinotecan and 5-fluorouracil plus folinic acid neoadjuvant chemotherapy for unresectable liver metastases.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  55. OSTERLUND P , Ruotsalainen T, Korpela R, Saxelin M, et al
    Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  56. PENEGAR S , Wood W, Lubbe S, Chandler I, et al
    National study of colorectal cancer genetics.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  57. SCHIPPINGER W , Samonigg H, Schaberl-Moser R, Greil R, et al
    A prospective randomised phase III trial of adjuvant chemotherapy with 5-fluorouracil and leucovorin in patients with stage II colon cancer.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  58. PIETERSE AH , Stiggelbout AM, Baas-Thijssen MC, van de Velde CJ, et al
    Benefit from preoperative radiotherapy in rectal cancer treatment: disease-free patients' and oncologists' preferences.
    Br J Cancer. 2007;97:717-24.
    PubMed     Related articles    Abstract available


  59. FANCIULLINO R , Giacometti S, Mercier C, Aubert C, et al
    In vitro and in vivo reversal of resistance to 5-fluorouracil in colorectal cancer cells with a novel stealth double-liposomal formulation.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


    August 2007
  60. GUO X , Evans TR, Somanath S, Armesilla AL, et al
    In vitro evaluation of cancer-specific NF-kappaB-CEA enhancer-promoter system for 5-fluorouracil prodrug gene therapy in colon cancer cell lines.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


    July 2007
  61. DELORD JP , Bennouna J, Artru P, Perrier H, et al
    Phase II study of UFT with leucovorin and irinotecan (TEGAFIRI): first-line therapy for metastatic colorectal cancer.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  62. OTANI T , Iwasaki M, Sasazuki S, Inoue M, et al
    Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  63. SCARTOZZI M , Bearzi I, Berardi R, Mandolesi A, et al
    Epidermal growth factor receptor (EGFR) downstream signalling pathway in primary colorectal tumours and related metastatic sites: optimising EGFR-targeted treatment options.
    Br J Cancer. 2007;97:92-7.
    PubMed     Related articles    Abstract available


    June 2007
  64. EL-EMIR E , Dearling JL, Huhalov A, Robson MP, et al
    Characterisation and radioimmunotherapy of L19-SIP, an anti-angiogenic antibody against the extra domain B of fibronectin, in colorectal tumour models.
    Br J Cancer. 2007;96:1862-70.
    PubMed     Related articles    Abstract available


  65. LIU J , Harada H, Ogura M, Shibata T, et al
    Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts.
    Br J Cancer. 2007;96:1871-8.
    PubMed     Related articles    Abstract available


  66. OIKONOMOU E , Kothonidis K, Zografos G, Nasioulas G, et al
    Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  67. KABAT GC , Miller AB, Jain M, Rohan TE, et al
    A cohort study of dietary iron and heme iron intake and risk of colorectal cancer in women.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  68. THIRLWELL C , Howarth KM, Segditsas S, Guerra G, et al
    Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
    Br J Cancer. 2007;96:1729-34.
    PubMed     Related articles    Abstract available


  69. BOREL M , Degoul F, Communal Y, Mounetou E, et al
    N-(4-iodophenyl)-N'-(2-chloroethyl)urea as a microtubule disrupter: in vitro and in vivo profiling of antitumoral activity on CT-26 murine colon carcinoma cell line cultured and grafted to mice.
    Br J Cancer. 2007;96:1684-91.
    PubMed     Related articles    Abstract available


  70. ALTIERI A , Hemminki K
    Number of siblings and the risk of solid tumours: a nation-wide study.
    Br J Cancer. 2007;96:1755-9.
    PubMed     Related articles    Abstract available


    May 2007
  71. MANSILLA F , Birkenkamp-Demtroder K, Kruhoffer M, Sorensen FB, et al
    Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  72. OVERBEEK LI , Kets CM, Hebeda KM, Bodmer D, et al
    Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer.
    Br J Cancer. 2007;96:1605-12.
    PubMed     Related articles    Abstract available


  73. ANDERSON JA , Grabowska AM, Watson SA
    PTHrP increases transcriptional activity of the integrin subunit alpha5.
    Br J Cancer. 2007;96:1394-403.
    PubMed     Related articles    Abstract available


    April 2007
  74. CASTIGLIONE G , Visioli CB, Ciatto S, Grazzini G, et al
    Sensitivity of latex agglutination faecal occult blood test in the Florence District population-based colorectal cancer screening programme.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  75. SAKAMOTO J , Hamada C, Yoshida S, Kodaira S, et al
    An individual patient data meta-analysis of adjuvant therapy with uracil-tegafur (UFT) in patients with curatively resected rectal cancer.
    Br J Cancer. 2007;96:1170-7.
    PubMed     Related articles    Abstract available


  76. ALMOND J , Ralston S
    The clinical and economic benefits of capecitabine and tegafur with uracil in metastatic colorectal cancer.
    Br J Cancer. 2007;.
    PubMed     Related articles   


  77. WARD SE
    Reply: The clinical and economic benefits of capecitabine and tegafur with uracil in metastatic colorectal cancer.
    Br J Cancer. 2007;.
    PubMed     Related articles   


  78. NEHLS O , Okech T, Hsieh CJ, Enzinger T, et al
    Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  79. PUPPA G , Maisonneuve P, Sonzogni A, Masullo M, et al
    Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma.
    Br J Cancer. 2007;96:1118-26.
    PubMed     Related articles    Abstract available


  80. WELSH FK , Tilney HS, Tekkis PP, John TG, et al
    Safe liver resection following chemotherapy for colorectal metastases is a matter of timing.
    Br J Cancer. 2007;96:1037-42.
    PubMed     Related articles    Abstract available


  81. HAUG U , Rothenbacher D, Wente MN, Seiler CM, et al
    Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


    March 2007
  82. WILLEKE F , Horisberger K, Kraus-Tiefenbacher U, Wenz F, et al
    A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancer.
    Br J Cancer. 2007;96:912-7.
    PubMed     Related articles    Abstract available


  83. DI FIORE F , Blanchard F, Charbonnier F, Le Pessot F, et al
    Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  84. STANLEY M
    Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  85. NERI B , Pantaleo P, Giommoni E, Grifoni R, et al
    Oxaliplatin, 5-fluorouracil/leucovorin and epirubicin as first-line treatment in advanced gastric carcinoma: a phase II study.
    Br J Cancer. 2007;.
    PubMed     Related articles    Abstract available


  86. GIOVANNETTI E , Backus HH, Wouters D, Ferreira CG, et al
    Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
    Br J Cancer. 2007;96:769-75.
    PubMed     Related articles    Abstract available


    February 2007
  87. GLYNNE-JONES R , Falk S, Maughan TS, Meadows HM, et al
    A phase I/II study of irinotecan when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group Study.
    Br J Cancer. 2007;96:551-8.
    PubMed     Related articles    Abstract available


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