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	The Medical Article of the Year 2008: Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78. Free full-text

Colorectal Neoplasms

Free Subscription Articles published in Clin Cancer Res Retrieve available abstracts of 111 articles: HTML format

Single Articles

July 2008
1. CHEN TH , Pan SL, Guh JH, Liao CH, et al
   Moscatilin Induces Apoptosis in Human Colorectal Cancer Cells: A Crucial Role of c-Jun NH2-Terminal Protein Kinase Activation Caused by Tubulin Depolymerization and DNA Damage.
   Clin Cancer Res. 2008;14:4250-8.
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2. VINCENZI B , Santini D, Galluzzo S, Russo A, et al
   Early magnesium reduction in advanced colorectal cancer patients treated with cetuximab plus irinotecan as predictive factor of efficacy and outcome.
   Clin Cancer Res. 2008;14:4219-24.
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3. CORREALE P , Tagliaferri P, Fioravanti A, Del Vecchio MT, et al
   Immunity Feedback and Clinical Outcome in Colon Cancer Patients Undergoing Chemoimmunotherapy with Gemcitabine + FOLFOX followed by Subcutaneous Granulocyte Macrophage Colony-Stimulating Factor and Aldesleukin (GOLFIG-1 Trial).
   Clin Cancer Res. 2008;14:4192-4199.
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   June 2008
4. GINTY F , Adak S, Can A, Gerdes M, et al
   The Relative Distribution of Membranous and Cytoplasmic Met Is a Prognostic Indicator in Stage I and II Colon Cancer.
   Clin Cancer Res. 2008;14:3814-22.
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5. ZLOBEC I , Terracciano LM, Lugli A
   Local Recurrence in Mismatch Repair-Proficient Colon Cancer Predicted by an Infiltrative Tumor Border and Lack of CD8+ Tumor-Infiltrating Lymphocytes.
   Clin Cancer Res. 2008;14:3792-7.
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6. YCHOU M , Azria D, Menkarios C, Faurous P, et al
   Adjuvant Radioimmunotherapy Trial with Iodine-131-Labeled Anti-Carcinoembryonic Antigen Monoclonal Antibody F6 F(ab')2 after Resection of Liver Metastases from Colorectal Cancer.
   Clin Cancer Res. 2008;14:3487-93.
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7. FRENCH AJ , Sargent DJ, Burgart LJ, Foster NR, et al
   Prognostic Significance of Defective Mismatch Repair and BRAF V600E in Patients with Colon Cancer.
   Clin Cancer Res. 2008;14:3408-15.
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   May 2008
8. DI PAOLO A , Lencioni M, Amatori F, Di Donato S, et al
   5-Fluorouracil Pharmacokinetics Predicts Disease-free Survival in Patients Administered Adjuvant Chemotherapy for Colorectal Cancer.
   Clin Cancer Res. 2008;14:2749-55.
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9. RAN Y , Hu H, Zhou Z, Yu L, et al
   Profiling tumor-associated autoantibodies for the detection of colon cancer.
   Clin Cancer Res. 2008;14:2696-700.
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10. FIDAROVA EF , El-Emir E, Boxer GM, Qureshi U, et al
    Microdistribution of targeted, fluorescently labeled anti-carcinoembryonic antigen antibody in metastatic colorectal cancer: implications for radioimmunotherapy.
    Clin Cancer Res. 2008;14:2639-46.
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    April 2008
11. WATANABE T , Yamamoto Y, Yamada H, Hayama T, et al
    Survival in microsatellite-unstable colorectal cancer.
    Clin Cancer Res. 2008;14:2516.
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12. SARKAR C , Chakroborty D, Chowdhury UR, Dasgupta PS, et al
    Dopamine Increases the Efficacy of Anticancer Drugs in Breast and Colon Cancer Preclinical Models.
    Clin Cancer Res. 2008;14:2502-2510.
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13. YAMADA M , Ichikawa Y, Yamagishi S, Momiyama N, et al
    Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer.
    Clin Cancer Res. 2008;14:2351-6.
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14. SPEETJENS FM , Kuppen PJ, Sandel MH, Menon AG, et al
    Disrupted Expression of CXCL5 in Colorectal Cancer Is Associated with Rapid Tumor Formation in Rats and Poor Prognosis in Patients.
    Clin Cancer Res. 2008;14:2276-84.
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15. DOUGHERTY U , Sehdev A, Cerda S, Mustafi R, et al
    Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model.
    Clin Cancer Res. 2008;14:2253-62.
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16. HUBNER RA , Muir KR, Liu JF, Logan RF, et al
    Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention.
    Clin Cancer Res. 2008;14:2303-9.
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17. OLIVER PG , Lobuglio AF, Zinn KR, Kim H, et al
    Treatment of Human Colon Cancer Xenografts with TRA-8 Anti-death Receptor 5 Antibody Alone or in Combination with CPT-11.
    Clin Cancer Res. 2008;14:2180-9.
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18. KUNNUMAKKARA AB , Diagaradjane P, Guha S, Deorukhkar A, et al
    Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to {gamma}-Radiation by Targeting Nuclear Factor-{kappa}B-Regulated Gene Products.
    Clin Cancer Res. 2008;14:2128-36.
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19. BROSTJAN C , Gebhardt K, Gruenberger B, Steinrueck V, et al
    Neoadjuvant treatment of colorectal cancer with bevacizumab: the perioperative angiogenic balance is sensitive to systemic thrombospondin-1 levels.
    Clin Cancer Res. 2008;14:2065-74.
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    March 2008
20. WEICHERT W , Roske A, Niesporek S, Noske A, et al
    Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases In vitro and In vivo.
    Clin Cancer Res. 2008;14:1669-77.
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21. SAPRA P , Zhao H, Mehlig M, Malaby J, et al
    Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model.
    Clin Cancer Res. 2008;14:1888-96.
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22. CRESCENZI E , Palumbo G, de Boer J, Brady HJ, et al
    Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy.
    Clin Cancer Res. 2008;14:1877-87.
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23. HOSKINS JM , Marcuello E, Altes A, Marsh S, et al
    Irinotecan pharmacogenetics: influence of pharmacodynamic genes.
    Clin Cancer Res. 2008;14:1788-96.
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24. MORRIS M , Platell C, Iacopetta B
    Tumor-infiltrating lymphocytes and perforation in colon cancer predict positive response to 5-Fluorouracil chemotherapy.
    Clin Cancer Res. 2008;14:1413-7.
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25. LEMAN ES , Schoen RE, Magheli A, Sokoll LJ, et al
    Evaluation of Colon Cancer-Specific Antigen 2 as a Potential Serum Marker for Colorectal Cancer.
    Clin Cancer Res. 2008;14:1349-1354.
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26. O'ROURKE M , Ward C, Worthington J, McKenna J, et al
    Evaluation of the antiangiogenic potential of AQ4N.
    Clin Cancer Res. 2008;14:1502-9.
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27. GIUSTI RM , Shastri K, Pilaro AM, Fuchs C, et al
    U.S. Food and Drug Administration approval: panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens.
    Clin Cancer Res. 2008;14:1296-302.
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    February 2008
28. WALSH MD , Cummings MC, Buchanan DD, Dambacher WM, et al
    Molecular, Pathologic, and Clinical Features of Early-Onset Endometrial Cancer: Identifying Presumptive Lynch Syndrome Patients.
    Clin Cancer Res. 2008;.
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29. MERCHANT NB , Voskresensky I, Rogers CM, Lafleur B, et al
    TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer.
    Clin Cancer Res. 2008;14:1182-1191.
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30. DE BRUIN EC , van de Velde CJ, van Krieken JH, Marijnen CA, et al
    Epithelial human leukocyte antigen-DR expression predicts reduced recurrence rates and prolonged survival in rectal cancer patients.
    Clin Cancer Res. 2008;14:1073-9.
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31. LIU W , Liu Y, Zhu J, Wright E, et al
    Reduced hGC-1 protein expression is associated with malignant progression of colon carcinoma.
    Clin Cancer Res. 2008;14:1041-9.
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32. ORTEGA P , Moran A, de Juan C, Frias C, et al
    Differential Wnt pathway gene expression and E-cadherin truncation in sporadic colorectal cancers with and without microsatellite instability.
    Clin Cancer Res. 2008;14:995-1001.
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33. SHARMA R , Hoskins JM, Rivory LP, Zucknick M, et al
    Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.
    Clin Cancer Res. 2008;14:817-25.
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34. EZUMI K , Yamamoto H, Murata K, Higashiyama M, et al
    Aberrant Expression of Connexin 26 Is Associated with Lung Metastasis of Colorectal Cancer.
    Clin Cancer Res. 2008;14:677-684.
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35. LI L , Plummer SJ, Thompson CL, Tucker TC, et al
    Association between Phosphatidylinositol 3-Kinase Regulatory Subunit p85{alpha} Met326Ile Genetic Polymorphism and Colon Cancer Risk.
    Clin Cancer Res. 2008;14:633-7.
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36. TWIGGER K , Vidal L, White CL, De Bono JS, et al
    Enhanced in vitro and in vivo cytotoxicity of combined reovirus and radiotherapy.
    Clin Cancer Res. 2008;14:912-23.
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37. MANEGOLD PC , Paringer C, Kulka U, Krimmel K, et al
    Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer.
    Clin Cancer Res. 2008;14:892-900.
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38. LIPS EH , van Eijk R, de Graaf EJ, Doornebosch PG, et al
    Progression and tumor heterogeneity analysis in early rectal cancer.
    Clin Cancer Res. 2008;14:772-81.
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39. DIAGARADJANE P , Orenstein-Cardona JM, E Colon-Casasnovas N, Deorukhkar A, et al
    Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe.
    Clin Cancer Res. 2008;14:731-41.
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    January 2008
40. HAN M , Liew CT, Zhang HW, Chao S, et al
    Novel Blood-Based, Five-Gene Biomarker Set for the Detection of Colorectal Cancer.
    Clin Cancer Res. 2008;.
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41. HU P , Arias RS, Sadun RE, Nien YC, et al
    Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer.
    Clin Cancer Res. 2008;14:579-88.
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42. JEONG JS , Lee SW, Hong SH, Lee YJ, et al
    Antitumor effects of systemically delivered adenovirus harboring trans-splicing ribozyme in intrahepatic colon cancer mouse model.
    Clin Cancer Res. 2008;14:281-90.
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43. FOLPRECHT G , Tabernero J, Kohne CH, Zacharchuk C, et al
    Phase I Pharmacokinetic/Pharmacodynamic Study of EKB-569, an Irreversible Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Combination with Irinotecan, 5-Fluorouracil, and Leucovorin (FOLFIRI) in First-Line Treatment of Patients with
    Clin Cancer Res. 2008;14:215-223.
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44. ZLOBEC I , Baker K, Minoo P, Jass JR, et al
    Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and raf-1 kinase inhibitor protein expression.
    Clin Cancer Res. 2008;14:143-8.
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45. KIM JG , Chae YS, Sohn SK, Cho YY, et al
    Vascular endothelial growth factor gene polymorphisms associated with prognosis for patients with colorectal cancer.
    Clin Cancer Res. 2008;14:62-6.
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46. YING J , Li H, Yu J, Ng KM, et al
    WNT5A Exhibits Tumor-Suppressive Activity through Antagonizing the Wnt/ -Catenin Signaling, and Is Frequently Methylated in Colorectal Cancer.
    Clin Cancer Res. 2008;14:55-61.
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47. VAN PUIJENBROEK M , Nielsen M, Tops CM, Halfwerk H, et al
    Identification of patients with (atypical) MUTYH-associated polyposis by KRAS2 c.34G > T prescreening followed by MUTYH hotspot analysis in formalin-fixed paraffin-embedded tissue.
    Clin Cancer Res. 2008;14:139-42.
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48. KUKITSU T , Takayama T, Miyanishi K, Nobuoka A, et al
    Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis.
    Clin Cancer Res. 2008;14:48-54.
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    December 2007
49. FAN Y , Wang W, Zhu M, Zhou J, et al
    Analysis of hMLH1 Missense Mutations in East Asian Patients with Suspected Hereditary Nonpolyposis Colorectal Cancer.
    Clin Cancer Res. 2007;13:7515-7521.
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50. ROKAVEC M , Justenhoven C, Schroth W, Istrate MA, et al
    A Novel Polymorphism in the Promoter Region of ERBB4 Is Associated with Breast and Colorectal Cancer Risk.
    Clin Cancer Res. 2007;13:7506-14.
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51. PREWETT M , Deevi DS, Bassi R, Fan F, et al
    Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab.
    Clin Cancer Res. 2007;13:7432-40.
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52. MA Q , Wang Y, Gao X, Ma Z, et al
    L-arginine reduces cell proliferation and ornithine decarboxylase activity in patients with colorectal adenoma and adenocarcinoma.
    Clin Cancer Res. 2007;13:7407-12.
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53. XUE H , Sawyer MB, Field CJ, Dieleman LA, et al
    Nutritional modulation of antitumor efficacy and diarrhea toxicity related to irinotecan chemotherapy in rats bearing the ward colon tumor.
    Clin Cancer Res. 2007;13:7146-54.
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    November 2007
54. LEONARDI MJ , McGory ML, Ko CY
    Quality of Care Issues in Colorectal Cancer.
    Clin Cancer Res. 2007;13:6897s-6902s.
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55. LYNCH PM
    New Issues in Genetic Counseling of Hereditary Colon Cancer.
    Clin Cancer Res. 2007;13:6857s-6861s.
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56. BENSON AB 3RD
    New approaches to assessing and treating early-stage colon and rectal cancers: cooperative group strategies for assessing optimal approaches in early-stage disease.
    Clin Cancer Res. 2007;13.
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57. GROTHEY A
    Biological therapy and other novel therapies in early-stage disease: are they appropriate?
    Clin Cancer Res. 2007;13.
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58. WILLETT CG , Czito BG, Bendell JC
    Radiation therapy in stage II and III rectal cancer.
    Clin Cancer Res. 2007;13.
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59. BOLLER AM , Nelson H
    Colon and rectal cancer: laparoscopic or open?
    Clin Cancer Res. 2007;13.
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60. BEART RW JR
    Multidisciplinary management of patients with advanced rectal cancer.
    Clin Cancer Res. 2007;13.
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61. STAMOS MJ , Murrell Z
    Management of early rectal T1 and T2 cancers.
    Clin Cancer Res. 2007;13.
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62. MUTHUSAMY VR , Chang KJ
    Optimal methods for staging rectal cancer.
    Clin Cancer Res. 2007;13.
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63. TURNER RR , Li C, Compton CC
    Newer pathologic assessment techniques for colorectal carcinoma.
    Clin Cancer Res. 2007;13.
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64. COMPTON CC
    Optimal pathologic staging: defining stage II disease.
    Clin Cancer Res. 2007;13.
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65. ROSEN LS , Bilchik AJ, Beart RW Jr, Benson AB 3rd, et al
    New approaches to assessing and treating early-stage colon and rectal cancer: summary statement from 2007 Santa Monica Conference.
    Clin Cancer Res. 2007;13.
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66. SAGIV E , Rozovski U, Kazanov D, Liberman E, et al
    Gene expression analysis proposes alternative pathways for the mechanism by which celecoxib selectively inhibits the growth of transformed but not normal enterocytes.
    Clin Cancer Res. 2007;13.
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67. GOSENS MJ , Klaassen RA, Tan-Go I, Rutten HJ, et al
    Circumferential margin involvement is the crucial prognostic factor after multimodality treatment in patients with locally advanced rectal carcinoma.
    Clin Cancer Res. 2007;13.
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68. KIM JS , Lee YC, Nam HT, Li G, et al
    Apicularen A Induces Cell Death through Fas Ligand Up-Regulation and Microtubule Disruption by Tubulin Down-Regulation in HM7 Human Colon Cancer Cells.
    Clin Cancer Res. 2007;13:6509-6517.
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69. TROIANI T , Serkova NJ, Gustafson DL, Henthorn TK, et al
    Investigation of Two Dosing Schedules of Vandetanib (ZD6474), an Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling, in Combination with Irinotecan in a Human Colon Cancer Xenograft Model.
    Clin Cancer Res. 2007;13:6450-6458.
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70. GARCIA JM , Pena C, Garcia V, Dominguez G, et al
    Prognostic Value of LISCH7 mRNA in Plasma and Tumor of Colon Cancer Patients.
    Clin Cancer Res. 2007;13:6351-6358.
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    October 2007
71. SHEN L , Catalano PJ, Benson AB 3rd, O'Dwyer P, et al
    Association between DNA Methylation and Shortened Survival in Patients with Advanced Colorectal Cancer Treated with 5-Fluorouracil Based Chemotherapy.
    Clin Cancer Res. 2007;13:6093-8.
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72. GROSSMAN SR , Lyle S, Resnick MB, Sabo E, et al
    p66 Shc Tumor Levels Show a Strong Prognostic Correlation with Disease Outcome in Stage IIA Colon Cancer.
    Clin Cancer Res. 2007;13:5798-804.
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73. SANCHEZ-DE-ABAJO A , de la Hoya M, van Puijenbroek M, Tosar A, et al
    Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways.
    Clin Cancer Res. 2007;13:5729-35.
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74. CHEADLE EJ , Riyad K, Subar D, Rothwell DG, et al
    Eotaxin-2 and Colorectal Cancer: A Potential Target for Immune Therapy.
    Clin Cancer Res. 2007;13:5719-5728.
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75. DE HEER P , de Bruin EC, Klein-Kranenbarg E, Aalbers RI, et al
    Caspase-3 activity predicts local recurrence in rectal cancer.
    Clin Cancer Res. 2007;13:5810-5.
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    September 2007
76. SEZEUR A , Chatelet FP, Cywiner Ch, de Labriolle-Vaylet C, et al
    Pathology Underrates Colon Cancer Extranodal and Nodal Metastases; Ex vivo Radioimmunodetection Helps Staging.
    Clin Cancer Res. 2007;13:5592s-7s.
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77. MARTENSSON L , Nilsson R, Ohlsson T, Sjogren HO, et al
    Improved tumor targeting and decreased normal tissue accumulation through extracorporeal affinity adsorption in a two-step pretargeting strategy.
    Clin Cancer Res. 2007;13.
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78. ULLENHAG GJ , Mukherjee A, Watson NF, Al-Attar AH, et al
    Overexpression of FLIPL Is an Independent Marker of Poor Prognosis in Colorectal Cancer Patients.
    Clin Cancer Res. 2007;13:5070-5.
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79. XU F , Wang F, Di M, Huang Q, et al
    Classification based on the combination of molecular and pathologic predictors is superior to molecular classification on prognosis in colorectal carcinoma.
    Clin Cancer Res. 2007;13:5082-8.
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    August 2007
80. MESSERSMITH WA , Hidalgo M
    Panitumumab, a monoclonal anti epidermal growth factor receptor antibody in colorectal cancer: another one or the one?
    Clin Cancer Res. 2007;13:4664-6.
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81. WATANABE Y , Toyota M, Kondo Y, Suzuki H, et al
    PRDM5 Identified as a Target of Epigenetic Silencing in Colorectal and Gastric Cancer.
    Clin Cancer Res. 2007;13:4786-94.
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82. HARROP R , Drury N, Shingler W, Chikoti P, et al
    Vaccination of Colorectal Cancer Patients with Modified Vaccinia Ankara Encoding the Tumor Antigen 5T4 (TroVax) Given Alongside Chemotherapy Induces Potent Immune Responses.
    Clin Cancer Res. 2007;13:4487-94.
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83. BOTTARELLI L , Azzoni C, Necchi F, Lagrasta C, et al
    Sex chromosome alterations associate with tumor progression in sporadic colorectal carcinomas.
    Clin Cancer Res. 2007;13.
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    July 2007
84. SORENSEN NM , Bystrom P, Christensen IJ, Berglund A, et al
    TIMP-1 Is Significantly Associated with Objective Response and Survival in Metastatic Colorectal Cancer Patients Receiving Combination of Irinotecan, 5-Fluorouracil, and Folinic Acid.
    Clin Cancer Res. 2007;13:4117-22.
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85. JU J , Schmitz JC, Song B, Kudo K, et al
    Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells.
    Clin Cancer Res. 2007;13:4245-51.
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86. MALESCI A , Laghi L, Bianchi P, Delconte G, et al
    Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer.
    Clin Cancer Res. 2007;13:3831-9.
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87. CAMPBELL PT , Edwards L, McLaughlin JR, Green J, et al
    Cytochrome P450 17A1 and Catechol O-Methyltransferase Polymorphisms and Age at Lynch Syndrome Colon Cancer Onset in Newfoundland.
    Clin Cancer Res. 2007;13:3783-8.
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    June 2007
88. SKOGLUND J , Song B, Dalen J, Dedorson S, et al
    Lack of an Association between the TGFBR1*6A Variant and Colorectal Cancer Risk.
    Clin Cancer Res. 2007;13:3748-52.
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89. WANG WS , Chen PM, Chiou TJ, Liu JH, et al
    Epidermal growth factor receptor R497K polymorphism is a favorable prognostic factor for patients with colorectal carcinoma.
    Clin Cancer Res. 2007;13:3597-604.
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90. BETTSTETTER M , Dechant S, Ruemmele P, Grabowski M, et al
    Distinction of Hereditary Nonpolyposis Colorectal Cancer and Sporadic Microsatellite-Unstable Colorectal Cancer through Quantification of MLH1 Methylation by Real-time PCR.
    Clin Cancer Res. 2007;13:3221-8.
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91. COTE JF , Kirzin S, Kramar A, Mosnier JF, et al
    UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan.
    Clin Cancer Res. 2007;13:3269-75.
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    May 2007
92. STISH BJ , Chen H, Shu Y, Panoskaltsis-Mortari A, et al
    Increasing anticarcinoma activity of an anti-erbB2 recombinant immunotoxin by the addition of an anti-EpCAM sFv.
    Clin Cancer Res. 2007;13:3058-67.
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93. DE HEER P , Gosens MJ, de Bruin EC, Dekker-Ensink NG, et al
    Cyclooxygenase 2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy.
    Clin Cancer Res. 2007;13:2955-60.
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