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	The Medical Article of the Year 2008: Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78. Free full-text

Diabetes

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July 2008
1. SIMONE S , Gorin Y, Velagapudi C, Abboud HE, et al
   Mechanism of Oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme OGG1.
   Diabetes. 2008;.
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2. ASLEH R , Blum S, Kalet-Litman S, Alsheik J, et al
   Correction of HDL dysfunction in individuals with Diabetes and the Haptoglobin 2-2 genotype.
   Diabetes. 2008;.
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3. PADMOS RC , Schloot NC, Beyan H, Ruwhof C, et al
   DISTINCT MONOCYTE GENE-EXPRESSION PROFILES IN Autoimmune DIABETES.
   Diabetes. 2008;.
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4. HARRIES LW , Sloman MJ, Sellers EA, Hattersley AT, et al
   Diabetes susceptibility in the Canadian Oji-Cree population is moderated by abnormal mRNA processing of HNF1A G319S transcripts.
   Diabetes. 2008;57:1978-82.
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5. JAMES EA , Kwok WW
   Low-affinity major histocompatibility complex-binding peptides in type 1 diabetes.
   Diabetes. 2008;57:1788-9.
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6. SCHMITZ-PEIFFER C , Biden TJ
   Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes.
   Diabetes. 2008;57:1774-83.
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7. ABDI R , Fiorina P, Adra CN, Atkinson M, et al
   Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes.
   Diabetes. 2008;57:1759-67.
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   June 2008
8. FUKUDA A , Kawaguchi Y, Furuyama K, Kodama S, et al
   Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes mellitus in mice.
   Diabetes. 2008;.
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9. MZHAVIA N , Yu S, Ikeda S, Chu TT, et al
   Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice.
   Diabetes. 2008;.
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10. LANGO H , Palmer CN, Morris AD, Zeggini E, et al
    Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
    Diabetes. 2008;.
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11. WENZLAU JM , Liu Y, Yu L, Moua O, et al
    A common non-synonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.
    Diabetes. 2008;.
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12. HUANG Y , Fugier-Vivier IJ, Miller T, Elliott MJ, et al
    Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: are they a component of diabetes pathogenesis?
    Diabetes. 2008;.
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13. GRARUP N , Andersen G, Krarup NT, Albrechtsen A, et al
    Association testing of novel type 2 diabetes risk-alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.
    Diabetes. 2008;.
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14. PFISTER F , Feng Y, Vom Hagen F, Hoffmann S, et al
    Pericyte migration: A novel mechanism of pericyte loss in experimental diabetic retinopathy.
    Diabetes. 2008;.
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15. LI CALZI S , Purich DL, Hee Chang K, Afzal A, et al
    Carbon Monoxide and Nitric Oxide Mediate Cytoskeletal Reorganization in Microvascular Cells via Vasodilator-Stimulated Phosphoprotein (VASP) Phosphorylation: Evidence for Blunted Responsiveness in Diabetes.
    Diabetes. 2008;.
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16. ROGUS JJ , Poznik GD, Pezzolesi MG, Smiles AM, et al
    High-density SNP genome wide linkage scan for susceptibility genes for diabetic nephropathy in type 1 diabetes: Discordant sib-pair approach.
    Diabetes. 2008;.
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17. MONTI P , Scirpoli M, Maffi P, Piemonti L, et al
    Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T cells.
    Diabetes. 2008;.
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18. BUTTY V , Campbell C, Mathis D, Benoist C, et al
    Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial.
    Diabetes. 2008;.
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19. VAXILLAIRE M , Cavalcanti-Proenca C, Dechaume A, Tichet J, et al
    The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels, and reduces type 2 diabetes risk in a prospective general French population: the D.E.S.I.R. Study.
    Diabetes. 2008;.
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20. MOORE AF , Jablonski KA, McAteer JB, Saxena R, et al
    EXTENSION OF TYPE 2 DIABETES GENOME-WIDE ASSOCIATION SCAN RESULTS IN THE DIABETES PREVENTION PROGRAM.
    Diabetes. 2008;.
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21. MAKINEN VP , Forsblom C, Thorn LM, Waden J, et al
    Metabolic Phenotypes, Vascular Complications and Premature Deaths in a Population of 4,197 Patients with Type 1 Diabetes.
    Diabetes. 2008;.
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22. WANIC K , Placha G, Dunn J, Smiles A, et al
    Exclusion of polymorphisms in carnosinase genes (CNDP1 & CNDP2) as cause of diabetic nephropathy in type 1 diabetes mellitus. Results of large case - control and follow - up studies.
    Diabetes. 2008;.
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23. NG DP , Tai BC, Li LX
    IS THE PRESENCE OF RETINOPATHY OF PRACTICAL VALUE IN DEFINING CASES OF DIABETIC NEPHROPATHY IN GENETIC ASSOCIATION STUDIES? THE EXPERIENCE WITH THE ANGIOTENSIN-I CONVERTING ENZYME I/D POLYMORPHISM BASED ON 53 STUDIES COMPRISING 17,791 SUBJECTS.
    Diabetes. 2008;.
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24. STANGER BZ
    HNF4A and diabetes: injury before insult?
    Diabetes. 2008;57:1461-2.
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25. KATO H , Si H, Hostetter T, Susztak K, et al
    Smad1 as a biomarker for diabetic nephropathy.
    Diabetes. 2008;57:1459-60.
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26. FORBES JM , Coughlan MT, Cooper ME
    Oxidative stress as a major culprit in kidney disease in diabetes.
    Diabetes. 2008;57:1446-54.
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27. QIAN Y , Feldman E, Pennathur S, Kretzler M, et al
    From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy.
    Diabetes. 2008;57:1439-45.
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28. THALLAS-BONKE V , Forbes JM
    Response to Comment on: Thallas-Bonke et al. (2008) Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product-Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-{alpha}-Dependent Pathway: Diabetes 57:460-469, 2008.
    Diabetes. 2008;57:e14.
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29. YAMAGISHI S
    Comment on: Thallas-Bonke et al. (2008) Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway: Diabetes 57:460-469, 2008.
    Diabetes. 2008;57:e13.
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    May 2008
30. SORO-PAAVONEN A , Watson AM, Li J, Paavonen K, et al
    RAGE DEFICIENCY ATTENUATES THE DEVELOPMENT OF ATHEROSCLEROSIS IN DIABETES.
    Diabetes. 2008;.
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31. ZHANG L , Cannell MB, Phillips AR, Cooper GJ, et al
    Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy.
    Diabetes. 2008;.
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32. RIGBY MR , Trexler AM, Pearson TC, Larsen CP, et al
    CD28/CD154 blockade prevents autoimmune diabetes by inducing non-deletional tolerance following effector T cell inhibition and regulatory T cell expansion.
    Diabetes. 2008;.
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33. LI L , Wang B, Frelinger JA, Tisch R, et al
    T cell promiscuity in autoimmune diabetes.
    Diabetes. 2008;.
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34. KURIHARA T , Ozawa Y, Nagai N, Shinoda K, et al
    Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina.
    Diabetes. 2008;.
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35. HAN J , Zhong J, Wei W, Wang Y, et al
    Extracellular HMGB1 acts as an innate immune-mediator to enhance autoimmune progression and diabetes onset in NOD mice.
    Diabetes. 2008;.
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36. BESIN G , Gaudreau S, Menard M, Guindi C, et al
    TSLP and TSLP-conditioned dendritic cells induce Treg differentiation and protection of NOD mice against diabetes.
    Diabetes. 2008;.
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37. NG MC , Park KS, Oh B, Tam CH, et al
    Implication of Genetic Variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2 and FTO in Type 2 Diabetes and Obesity in 6719 Asians.
    Diabetes. 2008;.
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38. SAM S , Haffner S, Davidson MH, D'Agostino RB, et al
    Relationship of Abdominal Visceral and Subcutaneous Adipose Tissue to Lipoprotein Particle Number and Size in Type 2 Diabetes.
    Diabetes. 2008;.
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39. SATAPATI S , He T, Inagaki T, Potthoff M, et al
    Partial resistance to PPAR{alpha} agonists in Zucker diabetic fatty (ZDF) rats is associated with defective hepatic mitochondrial metabolism.
    Diabetes. 2008;.
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40. STECK AK , Eisenbarth GS
    Genetic similarities between latent autoimmune diabetes and type 1 and type 2 diabetes.
    Diabetes. 2008;57:1160-2.
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41. ROEP BO
    Islet autoreactive CD8 T-cells in type 1 diabetes: licensed to kill?
    Diabetes. 2008;57:1156.
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42. HANLEY AJ , Wagenknecht LE
    Abdominal adiposity and diabetes risk: the importance of precise measures and longitudinal studies.
    Diabetes. 2008;57:1153-5.
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43. IVARSSON SA , Lernmark A
    Comment on: Edghill et al. (2008) Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood: Diabetes 57:1034-1042, 2008.
    Diabetes. 2008;57:e9.
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44. DICHIARA J , Bliden KP, Tantry US, Hamed MS, et al
    Response to Comment on: DiChiara et al. (2007) The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic Patients: An Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study: Diabetes 56:3014-3019, 2007.
    Diabetes. 2008;57:e11.
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45. KLEIN PS
    Comment on: DiChiara et al. (2007) The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) study: Diabetes 56:3014-3019, 2007.
    Diabetes. 2008;57:e10.
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    April 2008
46. NEHIRI T , Duong Van Huyen JP, Viltard M, Fassot C, et al
    EXPOSURE TO MATERNAL DIABETES INDUCES SALT-SENSITIVE HYPERTENSION AND IMPAIRS RENAL FUNCTION IN ADULT RAT OFFSPRING.
    Diabetes. 2008;.
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47. LEWIS JP , Palmer ND, Hicks PJ, Sale MM, et al
    Association Analysis of European-Derived Type 2 Diabetes SNPs from Whole Genome Association Studies in African Americans.
    Diabetes. 2008;.
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48. KIM YH , Kim YS, Park CH, Chung IY, et al
    Protein kinase C {delta} mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway.
    Diabetes. 2008;.
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49. HIETALA K , Forsblom C, Summanen P, Groop PH, et al
    Heritability of proliferative diabetic retinopathy.
    Diabetes. 2008;.
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50. DUESING K , Fatemifar G, Charpentier G, Marre M, et al
    Evaluation of the Association of IGF2BP2 Variants with Type 2 Diabetes in French Caucasians.
    Diabetes. 2008;.
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51. QU HQ , Grant SF, Bradfield JP, Kim C, et al
    Association analysis of the type 2 diabetes loci in type 1 diabetes.
    Diabetes. 2008;.
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52. BUCCIARELLI LG , Ananthakrishnan R, Hwang YC, Kaneko M, et al
    RAGE & MODULATION OF ISCHEMIC INJURY IN THE DIABETIC MYOCARDIUM.
    Diabetes. 2008;.
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53. WANG CJ , Chou FC, Chu CH, Wu JC, et al
    Protective Role of Programmed Death 1 Ligand 1 in Nonobese Diabetic Mice: The Paradox in Transgenic Models.
    Diabetes. 2008;.
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54. WANG ZQ , Cefalu WT, Zhang XH, Yu Y, et al
    Human adenovirus type 36 enhances glucose uptake in diabetic and non-diabetic human skeletal muscle cells independent of insulin signaling.
    Diabetes. 2008;.
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55. BASU R , Chandramouli V, Dicke B, Landau BR, et al
    The Plasma C5 Glucose/2H2O Ratio Does Not Provide an Accurate Assessment of Gluconeogenesis during Hyperinsulinemic Euglycemic Clamps in either Non-Diabetic or Diabetic Humans.
    Diabetes. 2008;.
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56. HARRIES LW , Sloman MJ, Sellers EA, Hattersley AT, et al
    DIABETES SUSCEPTIBILITY IN THE CANADIAN OJI-CREE POPULATION IS MODERATED BY ABNORMAL mRNA PROCESSING OF HNF1A G319S TRANSCRIPTS.
    Diabetes. 2008;.
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57. LEVISETTI MG , Lewis DM, Suri A, Unanue ER, et al
    Weak proinsulin peptide-MHC complexes are targeted in autoimmune diabetes in mice.
    Diabetes. 2008;.
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58. GRUDEN G , Bruno G, Chaturvedi N, Burt D, et al
    SERUM HSP27 AND DIABETIC COMPLICATIONS IN THE EURODIAB PROSPECTIVE COMPLICATIONS STUDY: A NOVEL CIRCULATING MARKER FOR DIABETIC NEUROPATHY.
    Diabetes. 2008;.
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59. ABDULHADI-ATWAN M , Bushmann J, Tornovsky-Babaey S, Perry A, et al
    Novel de novo mutation in SUR1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence.
    Diabetes. 2008;.
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60. ROSSETTI P , Porcellati F, Busciantella Ricci N, Candeloro P, et al
    EFFECT OF ORAL AMINO ACID ON COUNTERREGULATORY RESPONSES AND COGNITIVE FUNCTION DURING INSULIN-INDUCED HYPOGLYCEMIA IN NON-DIABETIC AND TYPE 1 DIABETIC PEOPLE.
    Diabetes. 2008;.
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61. GLASER B
    Insulin mutations in diabetes: the clinical spectrum.
    Diabetes. 2008;57:799-800.
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62. PALMER ND , Goodarzi MO, Langefeld CD, Ziegler J, et al
    Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study.
    Diabetes. 2008;57:1093-100.
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63. BLACK MH , Fingerlin TE, Allayee H, Zhang W, et al
    Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans.
    Diabetes. 2008;57:1048-56.
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    March 2008
64. CHANG S , Caramori ML, Moriya R, Mauer M, et al
    Having One Kidney Does Not Accelerate the Rate of Development of Diabetic Nephropathy Lesions in Type 1 Diabetic Patients.
    Diabetes. 2008;.
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65. LI M , Hyun Kim D, Tsenovoy PL, Peterson SJ, et al
    Treatment of Obese Diabetic Mice with an Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels and Improves Insulin Sensitivity and Glucose Tolerance.
    Diabetes. 2008;.
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66. MULLER KA , Ryals JM, Feldman EL, Wright DE, et al
    Abnormal Muscle Spindle Innervation and Large-Fiber Neuropathy in Diabetic Mice.
    Diabetes. 2008;.
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67. PENG F , Wu D, Gao B, Ingram AJ, et al
    RhoA/Rho-kinase Contribute to the Pathogenesis of Diabetic Renal Disease.
    Diabetes. 2008;.
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68. HAN S , Hagan DL, Taylor JR, Xin L, et al
    Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats.
    Diabetes. 2008;.
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69. W HARRIES L , Locke JM, Shields B, Hanley NA, et al
    The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development.
    Diabetes. 2008;.
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70. GUBITOSI-KLUG RA , Talahalli R, Du Y, Nadler JL, et al
    5-Lipoxygenase, but not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy.
    Diabetes. 2008;.
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71. TARASOV AI , Nicolson T, Riveline JP, Taneja TK, et al
    A rare mutation in ABCC8/SUR1 leading to altered KATP channel activity and {beta}-cell glucose sensing is associated with type 2 diabetes mellitus in adults.
    Diabetes. 2008;.
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72. FREATHY RM , Timpson NJ, Lawlor DA, Pouta A, et al
    Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected, given its effect on BMI.
    Diabetes. 2008;.
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73. HOLMKVIST J , Almgren P, Lyssenko V, Lindgren CM, et al
    Common variants in MODY genes and future risk of type 2 diabetes.
    Diabetes. 2008;.
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74. TIBERTI C , Giordano C, Locatelli M, Bosi E, et al
    Identification of tyrosine posphatase 2(256-760) construct as a new, sensitive marker for the detection of islet autoimmunity in type 2 diabetic patients (NIRAD Study 2).
    Diabetes. 2008;.
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75. FESTA A , Williams K, Hanley AJ, Haffner SM, et al
    Beta-cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes. Comparison of surrogate markers with first phase insulin secretion from an intravenous glucose tolerance test.
    Diabetes. 2008;.
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76. FIELD SF , Nejentsev S, Walker NM, Howson JM, et al
    Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.
    Diabetes. 2008;.
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77. QIU C , Cotch MF, Sigurdsson S, Garcia M, et al
    Retinal and Cerebral Microvascular Signs and Diabetes: The Age, Gene/Environment Susceptibility-Reykjavik Study.
    Diabetes. 2008;.
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78. BRUSSEE V , Guo G, Dong Y, Cheng C, et al
    DISTAL DEGENERATIVE SENSORY NEUROPATHY IN A LONG TERM TYPE 2 DIABETES RAT MODEL.
    Diabetes. 2008;.
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79. COSTACOU T , Ferrell RE, Orchard TJ
    Haptoglobin genotype: a determinant of cardiovascular complication risk in type 1 diabetes.
    Diabetes. 2008;.
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80. BELMADANI S , Palen DI, Gonzalez-Villalobos RA, Boulares HA, et al
    Elevated Epidermal Growth Factor Receptor Phosphorylation Induces Resistance Artery Dysfunction in Diabetic db/db mice.
    Diabetes. 2008;.
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81. PHILLIPS B , Nylander K, Harnaha J, Machen J, et al
    A MICROSPHERE-BASED VACCINE PREVENTS AND REVERSES NEW-ONSET AUTOIMMUNE DIABETES.
    Diabetes. 2008;.
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82. ANDERSEN G , Burgdorf KS, Sparso T, Borch-Johnsen K, et al
    AHSG tagSNPs associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 Danish whites.
    Diabetes. 2008;.
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83. DO R , Bailey SD, Desbiens K, Belisle A, et al
    Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels and Resting Metabolic Rate in the Quebec Family Study.
    Diabetes. 2008;.
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84. BACH LA
    Rho kinase inhibition: a new approach for treating diabetic nephropathy?
    Diabetes. 2008;57:532-3.
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85. FOUSTERI G , von Herrath M
    First-trimester human fetal pancreas transplantation for type 1 diabetes treatment: an alternative approach for achieving long-term graft survival?
    Diabetes. 2008;57:525-6.
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86. TRITT M , Sgouroudis E, d'Hennezel E, Albanese A, et al
    Response to Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4+ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113-123, 2007.
    Diabetes. 2008;57:e7-e8.
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87. THOMAS DC , Mellanby RJ, Cooke A
    Comment on: Tritt et al. (2007) Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes: Diabetes 57:113-123, 2007.
    Diabetes. 2008;57:e6.
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88. SCHUIT FC , Drucker DJ
    Beta-cell replication by loosening the brakes of glucagon-like peptide-1 receptor signaling.
    Diabetes. 2008;57:529-31.
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89. RAFFEL LJ , Noble JA, Rotter JI
    HLA on chromosome 6: the story gets longer and longer.
    Diabetes. 2008;57:527-8.
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90. FRIEDMAN JE , Kirwan JP, Jing M, Presley L, et al
    Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum.
    Diabetes. 2008;57:606-13.
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91. CALVERT JW , Gundewar S, Jha S, Greer JJ, et al
    Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.
    Diabetes. 2008;57:696-705.
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    February 2008
92. CERVIN C , Lyssenko V, Bakhtadze E, Lindholm E, et al
    GENETIC SIMILARITIES BETWEEN LADA, TYPE 1 AND TYPE 2 DIABETES.
    Diabetes. 2008;.
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93. SMYTH DJ , Cooper JD, Howson JM, Walker NM, et al
    PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.
    Diabetes. 2008;.
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94. CANI PD , Rodrigo B, Knauf C, Waget A, et al
    Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.
    Diabetes. 2008;.
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95. MARTINUZZI E , Novelli G, Scotto M, Blancou P, et al
    The Frequency and Immunodominance of Islet-specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment.
    Diabetes. 2008;.
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96. CERIELLO A , Esposito K, Piconi L, Ihnat MA, et al
    Oscillating glucose is more deleterious on endothelial function and oxidative stress than mean glucose in normals and type 2 diabetic patients.
    Diabetes. 2008;.
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97. KIM SJ , Nian C, Doudet DJ, McIntosh CH, et al
    Inhibition of Dipeptidyl Peptidase IV (DPP-IV) with Sitagliptin (MK0431) Prolongs Islet Graft Survival in Streptozotocin (STZ)-induced Diabetic Mice.
    Diabetes. 2008;.
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98. PFLEGER C , Mortensen HB, Hansen L, Herder C, et al
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