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Irritable Bowel Syndrome, January 2011
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The sick building syndrome as a part of the autoimmune (auto-inflammatory)
syndrome induced by adjuvants.
Mod Rheumatol. 2010.
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Suppression of tumorigenesis: modulation of inflammatory cytokines by oral
administration of microencapsulated probiotic yogurt formulation.
Int J Inflam. 2010;2010:894972.
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DNFB-DNS hapten-induced colitis in mice should not be considered a model of
inflammatory bowel disease.
Inflamm Bowel Dis. 2010.
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Managing bile acid diarrhoea.
Therap Adv Gastroenterol. 2010;3:349-57.
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Use of probiotics in gastrointestinal disorders: what to recommend?
Therap Adv Gastroenterol. 2010;3:307-19.
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Challenges and prospects for pharmacotherapy in functional gastrointestinal
disorders.
Therap Adv Gastroenterol. 2010;3:291-305.
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Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant
irritable bowel syndrome.
Therap Adv Gastroenterol. 2010;3:165-72.
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Learning to live with irritabel bowel syndrome. The influence of a group-based
patient education programme on peoples' ability to manage illness in everyday
life.
Scand J Caring Sci. 2010 Dec 22. doi: 10.1111/j.1471-6712.2010.00855.
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Extending pharmacological spectrum of opioids beyond analgesia: Multifunctional
aspects in different pathophysiological states.
Neuropeptides. 2011.
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Alosetron for severe diarrhea-predominant irritable bowel syndrome: improving
patient outcomes.
Curr Med Res Opin. 2011.
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Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel
Syndrome.
PLoS One. 2010;5:e15591.
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Irritable bowel syndrome immune hypothesis. Part two: the role of cytokines.
Rev Esp Enferm Dig. 2010;102:711-717.
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Is Childhood Abuse or Neglect Associated With Symptom Reports and Physiological
Measures in Women With Irritable Bowel Syndrome?
Biol Res Nurs. 2010.
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Tumour necrosis factor-alpha expression in segmental colitis associated with
diverticulosis is related to the severity of the endoscopic damage.
Dig Liver Dis. 2010.
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Modulation of visceral hypersensitivity by glial cell line-derived neurotrophic
factor (GDNF) family receptor alpha-3 in colorectal afferents.
Am J Physiol Gastrointest Liver Physiol. 2010.
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Serotonin receptor diversity in the human colon: Expression of serotonin type 3
receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.
J Comp Neurol. 2011;519:420-32.
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Increased rate of irritable bowel syndrome and functional gastrointestinal
disorders after Clostridium difficile infection.
J Hosp Infect. 2010.
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Duodenal administered seal oil for patients with subjective food
hypersensitivity: an explorative open pilot study.
Int J Gen Med. 2010;3:383-92.
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[New therapeutical approaches for treatment of irritable bowel syndrome].
Med Monatsschr Pharm. 2010;33:285-92.
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Enteric nervous system in the small intestine: pathophysiology and clinical
implications.
Curr Gastroenterol Rep. 2010;12:358-65.
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Features and management of colonic diverticular disease.
Curr Gastroenterol Rep. 2010;12:399-407.
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Colon ischemia: recent insights and advances.
Curr Gastroenterol Rep. 2010;12:383-90.
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Health benefits of probiotics: are mixtures more effective than single strains?
Eur J Nutr. 2011.
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Attention to pain words in irritable bowel syndrome: Increased orienting and
speeded engagement.
Br J Health Psychol. 2011;16.
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[Rifaximin - A Non-Resorbable Antibiotic with Many Indications in
Gastroenterology.]
Z Gastroenterol. 2011.
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Possible pathogenetic roles of abdominal surgery in irritable bowel syndrome.
Med Hypotheses. 2011.
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Sexuality and Reproductive Risk Factors for Interstitial Cystitis/Painful Bladder
Syndrome in Women.
Urology. 2011.
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[Personality traits in patients referred for functional dyspepsia.]
Zhonghua Nei Ke Za Zhi. 2010;49:997-1001.
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[Irritable bowel syndrome. Extensive diagnosis is worthwhile].
MMW Fortschr Med. 2010;152:1 p following 43.
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[Effectiveness confirmed in studies. Intestine selective antibiotic reduces
irritable bowel syndrome effectively].
MMW Fortschr Med. 2010;152:2 p following 43.
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Cisapride for intestinal constipation.
Cochrane Database Syst Rev. 2011;1:CD007780.
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[Study on treatment of irritable bowel syndrome: based on relationship between
heart and intestines].
Zhongguo Zhen Jiu. 2010;30:957-9.
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Protocol for a randomized controlled study of Iyengar yoga for youth with
irritable bowel syndrome.
Trials. 2011;12:15.
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Treatment of irritable bowel syndrome with comorbid anxiety symptoms with
mirtazapine.
Clin Neuropharmacol. 2011;34:36-8.
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A protease inhibitor against acute stress-induced visceral hypersensitivity and
paracellular permeability in rats.
Eur J Pharmacol. 2011.
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Invasive potential of gut mucosa-derived fusobacterium nucleatum positively
correlates with IBD status of the host.
Inflamm Bowel Dis. 2011.
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Health tips. Squelch your belch.
Mayo Clin Health Lett. 2010;28:3.
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Diagnosis and management of IBS.
Nat Rev Gastroenterol Hepatol. 2010;7:565-81.
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Factors associated with co-morbid irritable bowel syndrome and chronic
fatigue-like symptoms in functional dyspepsia.
Neurogastroenterol Motil. 2011 Jan 24. doi: 10.1111/j.1365-2982.2010.01667.
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[Irritable Bowel Syndrome: German Consensus Guidelines on Definition,
Pathophysiology and Management.]
Z Gastroenterol. 2011.
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Internet-delivered treatment to promote health.
Curr Opin Psychiatry. 2011;24:168-72.
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Faecal calprotectin concentrations in apparently healthy children aged 0-12 years
in urban Kampala, Uganda: a community-based survey.
BMC Pediatr. 2011;11:9.
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A Neurological Approach to Biopsychosocial Medicine: Lessons from Irritable Bowel
Syndrome.
Biopsychosoc Med. 2011;5:1.
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Assessment of the association between Blastocystis infection and irritable bowel
syndrome.
J Med Assoc Thai. 2010;93 Suppl 6:S119-24.
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PDCD4 nuclear loss inversely correlates with miR-21 levels in colon
carcinogenesis.
Virchows Arch. 2011.
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[Celiac disease presenting as an intestinal intussusception: report of one case].
Rev Med Chil. 2010;138:1276-80.
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Associated Morbidity of Blepharitis.
Ophthalmology. 2011.
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Accelerated coronary atherosclerosis after execution of percutaneous coronary
intervention in patient with HIV/HCV coinfection: case report and review of the
literature.
Cardiovasc Revasc Med. 2011.
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[42-year-old patient with diarrhea since 6 months].
Dtsch Med Wochenschr. 2011;136.
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Efficacy and safety of oral lubiprostone in constipated patients with or without
irritable bowel syndrome: a randomized, placebo-controlled and dose-finding
study.
Neurogastroenterol Motil. 2011 Feb 9. doi: 10.1111/j.1365-2982.2011.01668.
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The microbiome-gut-brain axis: from bowel to behavior.
Neurogastroenterol Motil. 2011;23:187-92.
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Future indications for sacral nerve stimulation.
Colorectal Dis. 2011;13 Suppl 2:23-8.
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Mast cells in gastrointestinal disease.
Gastroenterol Hepatol (N Y). 2010;6:772-7.
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[Beyond Microbiota: Genetic Factors in Post-Infectious Irritable Bowel Syndrome.]
Z Gastroenterol. 2011;49:234-236.
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Evidence for Mast Cell Activation in Patients with Therapy-Resistant Irritable
Bowel Syndrome.
Z Gastroenterol. 2011;49:191-194.
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Diagnosing Irritable Bowel Syndrome: A Changing Clinical Paradigm.
South Med J. 2011.
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Diagnosis of Irritable Bowel Syndrome: What Are We Missing?
South Med J. 2011.
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Enhanced Excitability and Down-Regulated Voltage-Gated Potassium Channels in
Colonic DRG Neurons from Neonatal Maternal Separation Rats.
J Pain. 2011.
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Numbers and types of nonbladder syndromes as risk factors for interstitial
cystitis/painful bladder syndrome.
Urology. 2011;77:313-9.
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Psychological aspects and psychotherapy of inflammatory bowel diseases and
irritable bowel syndrome in children.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010;154:307-14.
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Dietary intakes in people with irritable bowel syndrome.
BMC Gastroenterol. 2011;11:9.
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Special issue: The Human Intestinal Microbiota.
Microbiology. 2010;156.
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Clinical Overview of Fibromyalgia.
Am J Ther. 2011.
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Magnetic resonance imaging of rectal volume in patients with irritable bowel
syndrome.
Dig Liver Dis. 2011.
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[Effect of Weichang'an pill on intestinal digestive ferment and the AQP4
concentration in proximal colon in IBS-D rats].
Zhongguo Zhong Yao Za Zhi. 2010;35:2899-903.
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Effects of octreotide on jejunal hypersensitivity triggered by Cryptosporidium
parvum intestinal infection in an immunocompetent suckling rat model.
Neurogastroenterol Motil. 2011 Feb 15. doi: 10.1111/j.1365-2982.2011.01680.
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Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity
in functional somatic disorders.
Biol Psychol. 2011.
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The role of experimental models in developing new treatments for irritable bowel
syndrome.
Expert Rev Gastroenterol Hepatol. 2011;5:43-57.
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5-HT(3) receptors: potential of individual isoforms for personalised therapy.
Curr Opin Pharmacol. 2011.
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MicroRNA in the regulation and expression of serotonergic transmission in the
brain and other tissues.
Curr Opin Pharmacol. 2011.
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Irritable bowel syndrome and risk of colorectal cancer: a Danish nationwide
cohort study.
Br J Cancer. 2011.
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Constipation and diarrhoea - common adverse drug reactions? A cross sectional
study in the general population.
BMC Clin Pharmacol. 2011;11:2.
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Variation of symptoms during the menstrual cycle in female patients with
gastroparesis.
Neurogastroenterol Motil. 2011 Feb 17. doi: 10.1111/j.1365-2982.2011.01681.
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[Probiotic therapy of the irritable bowel syndrome.]
Dtsch Med Wochenschr. 2011;136:371-375.
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Determination of the frequency of dyssynergic defecation and patient
characteristics in patients with functional constipation.
Turk J Gastroenterol. 2010;21:372-80.
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Microbial community and metabolomic comparison of irritable bowel syndrome
faeces.
J Med Microbiol. 2011.
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[Difficult consultations rather than difficult patients.]
Ned Tijdschr Geneeskd. 2011;155:A2821.
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Prevalence of irritable bowel syndrome: a community based study from northern
India.
J Neurogastroenterol Motil. 2011;17:82-7.
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Validation of New Symptom-Based Fibromyalgia Criteria for Irritable Bowel
Syndrome Co-morbidity Studies.
J Neurogastroenterol Motil. 2011;17:67-72.
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Prevalence of irritable bowel syndrome in northern India.
J Neurogastroenterol Motil. 2011;17:6-8.
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Therapeutics of 5-HT(3) receptor antagonists: Current uses and future directions.
Pharmacol Ther. 2011.
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Use of the Short-Form McGill Pain Questionnaire as a Diagnostic Tool in Women
with Chronic Pelvic Pain.
J Minim Invasive Gynecol. 2011;18:211-7.
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Suspended moxibustion relieves chronic visceral hyperalgesia and decreases
hypothalamic corticotropin-releasing hormone levels.
World J Gastroenterol. 2011;17:662-5.
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Natural history of heartburn: A 10-year population-based study.
World J Gastroenterol. 2011;17:639-45.
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[Guidelines for the Treatment of Irritable Bowel Syndrome.]
Korean J Gastroenterol. 2011;57:82-99.
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Distinct Neurophysiological Profiles In Irritable Bowel Syndrome.
Am J Physiol Gastrointest Liver Physiol. 2011.
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Central sensitivity syndromes: mounting pathophysiologic evidence to link
fibromyalgia with other common chronic pain disorders.
Pain Manag Nurs. 2011;12:15-24.
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Identification of the visceral pain pathway activated by noxious colorectal
distension in mice.
Front Neurosci. 2011;5:16.
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Lubiprostone for the treatment of opioid-induced bowel dysfunction.
Expert Opin Pharmacother. 2011.
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The role of psyllium fibre supplementation in treating irritable bowel syndrome.
Can J Diet Pract Res. 2011;72:48.
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Validation of the Japanese Version of Comorbid Conditions Questionnaire (CCQ-J)
and Recent Physical Symptoms Questionnaire (RPSQ-J).
Intern Med. 2011;50:375-80.
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Neuroimmune mechanisms in functional bowel disorders.
Neth J Med. 2011;69:55-61.
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Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia
in distal colon of neonatal maternal separated male rats.
Neurogastroenterol Motil. 2011 Mar 16. doi: 10.1111/j.1365-2982.2011.01697.
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Asymmetric Synthesis of an Antagonist of Neurokinin Receptors: SSR 241586.
J Org Chem. 2011.
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Effects of curcumin on the intestinal motility of albino rats.
Indian J Physiol Pharmacol. 2010;54:284-8.
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Depression's multiple comorbidities explained by (neuro)inflammatory and
oxidative & nitrosative stress pathways.
Neuro Endocrinol Lett. 2011;32.
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Short-chain fatty acid level and field cancerization show opposing associations
with enteroendocrine cell number and neuropilin expression in patients with
colorectal adenoma.
Mol Cancer. 2011;10:27.
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Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome.
Curr Opin Pharmacol. 2011.
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Questioning the Bacterial Overgrowth Hypothesis of IBS: An Epidemiologic and
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Clin Gastroenterol Hepatol. 2011.
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Placebo acupuncture as a form of ritual touch healing: A neurophenomenological
model.
Conscious Cogn. 2011.
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Entamoeba species associated with chronic diarrhoea in Pakistan.
Epidemiol Infect. 2011.
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Abdominal Migraine: An Under-Diagnosed Cause of Recurrent Abdominal Pain in
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Headache. 2011 Mar 11. doi: 10.1111/j.1526-4610.2011.01855.
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The Relationship between the Val158Met Catechol-o-Methyltransferase (COMT)
Polymorphism and Irritable Bowel Syndrome.
PLoS One. 2011;6:e18035.
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Complementary and alternative medicine modalities for the treatment of irritable
bowel syndrome: facts or myths?
Gastroenterol Hepatol (N Y). 2010;6:705-11.
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An unusual case of pediatric abdominal pain.
CJEM. 2011;13:133-8.
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In vitro sensitivity of Blastocystis hominis to garlic, ginger, white cumin, and
black pepper used in diet.
Parasitol Res. 2011.
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Long-term impact of irritable bowel syndrome: a qualitative study.
Prim Health Care Res Dev. 2011;12:52-67.
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Irritable bowel syndrome associated with mitral valve prolapse and autonomic and
haemostatic abnormalities in children, adolescents and adults with migraine.
Acta Neurol Scand. 2011;123:366-7.
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Perceptions of illness stigma in patients with inflammatory bowel disease and
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Qual Life Res. 2011.
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Transient receptor potential (TRP) channels as drug targets for diseases of the
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Pharmacol Ther. 2011.
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Colonic neoplasia in acromegaly: increased proliferation or deceased apoptosis?
Pituitary. 2011.
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The pharmacokinetics, pharmacodynamics, clinical efficacy, safety and
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Expert Opin Drug Metab Toxicol. 2011.
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[Forty cases of irritable bowel syndrome in diarrhea type treated with dog days
moxibustion].
Zhongguo Zhen Jiu. 2011;31:153-4.
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Operant learning of perceptual sensitization and habituation is impaired in
fibromyalgia patients with and without irritable bowel syndrome.
Pain. 2011.
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Combined effect of early life stress and acute stress on colonic sensory and
motor responses through serotonin pathways: Differences between proximal and
distal colon in rats.
Stress. 2011.
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Existing and emerging therapies for irritable bowel syndrome.
Expert Opin Emerg Drugs. 2011.
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Factor analysis identifies subgroups of constipation.
World J Gastroenterol. 2011;17:1468-74.
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The prevalence of celiac disease in patients with irritable bowel syndrome.
Mol Med Report. 2011;4:403-5.
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White matter abnormalities in irritable bowel syndrome and relation to individual
factors.
Brain Res. 2011.
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[Rome III classification of functional gastrointestinal disorders in children
with chronic abdominal pain].
Med Wieku Rozwoj. 2010;14:350-6.
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Anxiety, depression and quality of life in patients with irritable bowel
syndrome.
Gut Liver. 2011;5:29-36.
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Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS
with Constipation Compared to Plain Probiotic Fermented Milk.
Gut Liver. 2011;5:22-8.
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Successful treatment of asymptomatic or clinically terminal bovine Mycobacterium
avium subspecies paratuberculosis infection (Johne's disease) with the bacterium
Dietzia used as a probiotic alone or in combination with dexamethasone: Adaption
to chron
Virulence. 2011;2.
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Lactobacillus rhamnosus GG reduces frequency and severity of abdominal pain
compared with placebo in children with irritable bowel syndrome.
Evid Based Med. 2011.
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Qualitative and quantitative analysis of chemical constituents in traditional
Chinese medicinal formula Tong-Xie-Yao-Fang by high-performance liquid
chromatography/diode array detection/electrospray ionization tandem mass
spectrometry.
Anal Chim Acta. 2011;691.
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Amygdala Activation by Corticosterone Alters Visceral and Somatic Pain in Cycling
Female Rats.
Am J Physiol Gastrointest Liver Physiol. 2011.
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Deceptive irritations.
J Miss State Med Assoc. 2010;51:323-5.
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Diet, disease activity, and gastrointestinal symptoms in patients with ankylosing
spondylitis.
Clin Rheumatol. 2011;30:71-6.
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Chronic idiopathic large bowel diarrhea in the dog.
Vet Clin North Am Small Anim Pract. 2011;41:447-56.
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Further Validation of a Model of Fibromyalgia Syndrome in the Rat.
J Pain. 2011.
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[Recurrent abdominal pain in a patient with irritable bowel syndrome.]
Gastroenterol Hepatol. 2011.
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Nurses' experiences, expectations, and preferences for mind-body practices to
reduce stress.
BMC Complement Altern Med. 2011;11:26.
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Mediators of change in cognitive behaviour therapy and mebeverine for irritable
bowel syndrome.
Psychol Med. 2011.
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miRNA-based therapies for the irritable bowel syndrome.
Expert Opin Biol Ther. 2011.
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Cost-effectiveness of internet-based cognitive behavior therapy for Irritable
Bowel Syndrome: Results from a randomized controlled trial.
BMC Public Health. 2011;11:215.
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Prevalence and Co-occurrence of Upper and Lower Functional Gastrointestinal
Symptoms in Patients Eligible for Bariatric Surgery.
Obes Surg. 2011.
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[Research progress in the relationship between TRPV1 and visceral
hypersensitivity in functional gastrointestinal diseases.]
Beijing Da Xue Xue Bao. 2011;43:311-314.
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Small intestinal bacterial overgrowth in patients with lower gastrointestinal
symptoms and a history of previous abdominal surgery.
Arch Surg. 2011;146:444-7.
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High frequency of chronic bacterial and non-inflammatory prostatitis in infertile
patients with prostatitis syndrome plus irritable bowel syndrome.
PLoS One. 2011;6:e18647.
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The therapeutic value of hyper-suggestibility.
CMAJ. 2011;183:E149-50.
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[Prospects for using ladasten preparations in patients with irritable bowel
syndrome].
Eksp Klin Gastroenterol. 2010;:75-9.
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Measurement of (75)Se-SeHCAT abdominal retention in the initial diagnosis of Bile
Acid Absorption (BAM).
Rev Esp Med Nucl. 2011.
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Real-time PCR analysis of enteric pathogens from fecal samples of irritable bowel
syndrome subjects.
Gut Pathog. 2011;3:6.
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Stress enhances muscle nociceptor activity in the rat.
Neuroscience. 2011.
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Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat
model of irritable bowel syndrome.
J Ethnopharmacol. 2011.
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Calprotectin testing in the community.
Ann Clin Biochem. 2011;48.
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Heterogeneity amongst 5-HT receptor subunits: is this significant?
Curr Mol Med. 2011;11:57-68.
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Antibiotic treatment may ease symptoms of irritable bowel syndrome.
Mayo Clin Womens Healthsource. 2011;15:3.
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Mechanisms Underlying Visceral Hypersensitivity in Irritable Bowel Syndrome.
Curr Gastroenterol Rep. 2011.
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Treatment of postinfectious irritable bowel syndrome and noninfective irritable
bowel syndrome with mesalazine.
Arq Gastroenterol. 2011;48:36-40.
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Do interactions between stress and immune responses lead to symptom exacerbations
in irritable bowel syndrome?
Brain Behav Immun. 2011.
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[Post-infectious Irritable Bowel Syndrome.]
Clin Ter. 2011;162:157-161.
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[Therapeutic effect of acupoint catgut embedding on irritable bowel syndrome of
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Zhongguo Zhen Jiu. 2011;31:311-3.
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Microscopic colitis as a missed cause of chronic diarrhea.
World J Gastroenterol. 2011;17:1996-2002.
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Factors associated with irritable bowel syndrome symptoms in hemodialysis
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World J Gastroenterol. 2011;17:1976-81.
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Rifaximin for treatment of irritable bowel syndrome.
Gastroenterol Hepatol (N Y). 2011;7:180-1.
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Epidemiologic determinants of endometriosis among Egyptian women: a
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J Egypt Public Health Assoc. 2011;86.
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Preoperative symptoms of irritable bowel syndrome predict poor outcome after
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Surg Endosc. 2011.
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The Role of Eosinophils and Mast Cells in Intestinal Functional Disease.
Curr Gastroenterol Rep. 2011.
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Treatment of irritable bowel syndrome.
J Clin Pharm Ther. 2011;36:275-82.
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Vaccinations in patients with immune-mediated inflammatory diseases.
Rheumatology (Oxford). 2010;49:1815-27.
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Transient Gastric Irritation in the Neonatal Rats Leads to Changes in
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PLoS One. 2011;6:e19498.
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Gluten-free diet in nonceliac disease.
Nutr Clin Pract. 2011;26:294-9.
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P2X Receptors in Health and Disease.
Adv Pharmacol. 2011;61:333-72.
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Prevalence of irritable bowel syndrome (IBS) in first-degree relatives of
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J Crohns Colitis. 2011;5:227-33.
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Stress and visceral pain: From animal models to clinical therapies.
Exp Neurol. 2011.
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Restless legs syndrome is associated with irritable bowel syndrome and small
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Sleep Med. 2011.
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Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat
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Clin Nutr. 2011.
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Prediction of response to PPI therapy and factors influencing treatment outcome
in patients with GORD: a prospective pragmatic trial using pantoprazole.
BMC Gastroenterol. 2011;11:52.
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Altered expression and secretion of colonic Interleukin-6 in a stress-sensitive
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J Neuroimmunol. 2011.
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[Psychosomatic aspects of irritable bowel].
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[Luminal gastroenterology and inflammation.]
Dtsch Med Wochenschr. 2011;136:1197-1199.
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Internal medicine resident physicians may be uncomfortable with managing
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South Med J. 2011;104:380-1.
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Is There True Gender Difference of Irritable Bowel Syndrome in Asia?: Author's
Reply.
J Neurogastroenterol Motil. 2011;17:208.
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Is there true gender difference of irritable bowel syndrome in Asia?
J Neurogastroenterol Motil. 2011;17:206-7.
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Biopsychosocial model of irritable bowel syndrome.
J Neurogastroenterol Motil. 2011;17:131-9.
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Irritable Bowel Syndrome: What Do Patients Really Want?
Curr Gastroenterol Rep. 2011.
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[Prevalence of microscopic colitis in patients with irritable bowel syndrome with
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IBS in 2010: advances in pathophysiology, diagnosis and treatment.
Nat Rev Gastroenterol Hepatol. 2011;8:76-8.
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Low intake of vitamin B(6) is associated with irritable bowel syndrome symptoms.
Nutr Res. 2011;31:356-61.
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Targeting voltage-gated sodium channels for treatment for chronic visceral pain.
World J Gastroenterol. 2011;17:2357-64.
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Mechanisms of Pain Modulation by Sex Hormones in Migraine.
Headache. 2011;51:905-922.
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[The child with chronic diarrhoea: suggestions for workup.]
Ugeskr Laeger. 2011;173:1573-1576.
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Could chronic pelvic pain be a functional somatic syndrome?
Am J Obstet Gynecol. 2011.
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