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Irritable Bowel Syndrome, January 2018 Free Subscription Abstracts Retrieve all available abstracts of the following 257 articles: HTML format

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1. KIM JY, Park YJ, Lee HJ, Park MY, et al
   Effect of Lactobacillus gasseri BNR17 on irritable bowel syndrome: a randomized, double-blind, placebo-controlled, dose-finding trial.
   Food Sci Biotechnol. 2017;27:853-857.
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2. ZHANG QE, Wang F, Qin G, Zheng W, et al
   Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies.
   Int J Biol Sci. 2018;14:1504-1512.
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3. FARUP PG, Valeur J
   Faecal Microbial Markers and Psychobiological Disorders in Subjects with Morbid Obesity. A Cross-Sectional Study.
   Behav Sci (Basel). 2018;8.
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4. LI WT, Luo QQ, Wang B, Chen X, et al
   Bile acids induce visceral hypersensitivity via mucosal mast cell-to-nociceptor signaling that involves the farnesoid X receptor-nerve growth factor-transient receptor potential vanilloid 1 axis.
   FASEB J. 2018 Sep 27:fj201800935RR. doi: 10.1096/fj.201800935.
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5. BORDONI B, Morabito B
   Symptomatology Correlations Between the Diaphragm and Irritable Bowel Syndrome.
   Cureus. 2018;10:e3036.
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6. ADRIANI A, Ribaldone DG, Astegiano M, Durazzo M, et al
   Irritable bowel syndrome: the clinical approach.
   Panminerva Med. 2018 Sep 24. pii: S0031-0808.18.03541.
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7. NIELSEN ES, Garnas E, Jensen KJ, Hansen LH, et al
   Lacto-fermented sauerkraut improves symptoms in IBS patients independent of product pasteurisation - a pilot study.
   Food Funct. 2018 Sep 26. doi: 10.1039/c8fo00968.
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8. WELTENS N, Iven J, Van Oudenhove L, Kano M, et al
   The gut-brain axis in health neuroscience: implications for functional gastrointestinal disorders and appetite regulation.
   Ann N Y Acad Sci. 2018;1428:129-150.
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9. ABBASNEZHAD A, Amani R, Hasanvand A, Yousefi Rad E, et al
   Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome.
   J Am Coll Nutr. 2018 Sep 25:1-7. doi: 10.1080/07315724.2018.1510349.
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10. MOSER AM, Spindelboeck W, Halwachs B, Strohmaier H, et al
    Effects of an oral synbiotic on the gastrointestinal immune system and microbiota in patients with diarrhea-predominant irritable bowel syndrome.
    Eur J Nutr. 2018 Sep 24. pii: 10.1007/s00394-018-1826.
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11. MILLER L, Farajidavar A, Vegesna A
    Use of Bioelectronics in the Gastrointestinal Tract.
    Cold Spring Harb Perspect Med. 2018 Sep 24. pii: cshperspect.a034165.
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12. ILIAZ R, Akyuz F, Yegen G, Ormeci A, et al
    Does the number of mucosal immune cells differ in irritable bowel syndrome and its subtypes?
    Turk J Gastroenterol. 2018;29:384-391.
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13. NG QX, Soh AYS, Loke W, Venkatanarayanan N, et al
    A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome (IBS).
    J Clin Med. 2018;7.
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14. LIU Y, Tran DQ, Rhoads JM
    Probiotics in Disease Prevention and Treatment.
    J Clin Pharmacol. 2018;58 Suppl 10:S164-S179.
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15. AMANI R, Abbasnezhad A, Hajiani E, Cheraghian B, et al
    Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome.
    Iran J Immunol. 2018;15:186-196.
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16. LOPEZ-SILES M, Enrich-Capo N, Aldeguer X, Sabat-Mir M, et al
    Alterations in the Abundance and Co-occurrence of Akkermansia muciniphila and Faecalibacterium prausnitzii in the Colonic Mucosa of Inflammatory Bowel Disease Subjects.
    Front Cell Infect Microbiol. 2018;8:281.
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17. TURVILL J, Turnock D, Holmes H, Jones A, et al
    Evaluation of the clinical and cost-effectiveness of the York Faecal Calprotectin Care Pathway.
    Frontline Gastroenterol. 2018;9:285-294.
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18. MCDONALD E, Teets R, Ortiz C, Gilchrist C, et al
    A Randomized Trial of a Group-Based Integrative Medicine Approach Compared to Waitlist Control on Irritable Bowel Syndrome Symptoms in Adults.
    Explore (NY). 2018 Jul 20. pii: S1550-8307(18)30010.
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19. MEARIN F, Rey E, Santander C
    Irritable bowel syndrome: How to improve decision making in clinical practice.
    Med Clin (Barc). 2018 Sep 19. pii: S0025-7753(18)30442.
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20. BARISH CF, Crozier RA, Griffin P
    Long-term treatment with plecanatide was safe and tolerable in patients with irritable bowel syndrome with constipation.
    Curr Med Res Opin. 2018 Oct 2:1-15. doi: 10.1080/03007995.2018.1527303.
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21. GOLDENBERG JZ, Steel A, Day A, Yap C, et al
    Naturopathic approaches to irritable bowel syndrome: protocol for a prospective observational study in academic teaching clinics.
    Integr Med Res. 2018;7:279-286.
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22. YOON K, Kim N, Lee JY, Oh DH, et al
    Clinical Response of Rifaximin Treatment in Patients with Abdominal Bloating.
    Korean J Gastroenterol. 2018;72:121-127.
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23. AHMED JUNEJO S, Zhang L, Yang L, Wang N, et al
    Anti-hyperlipidaemic and hepatoprotective properties of wheat bran of different particle size.
    J Sci Food Agric. 2018 Oct 1. doi: 10.1002/jsfa.9397.
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24. FISHER E, Law E, Dudeney J, Palermo TM, et al
    Psychological therapies for the management of chronic and recurrent pain in children and adolescents.
    Cochrane Database Syst Rev. 2018;9:CD003968.
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25. KUNA A, Gajewski M
    Chronic symptoms persisting after travel-related infections.
    Int Marit Health. 2018;69:207-212.
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26. ABEL JL, Carson RT, Andrae DA
    The impact of treatment with eluxadoline on health-related quality of life among adult patients with irritable bowel syndrome with diarrhea.
    Qual Life Res. 2018 Sep 28. pii: 10.1007/s11136-018-2008.
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27. RUSSELL JP, Mohammadi E, Ligon C, Latorre R, et al
    Enteric RET inhibition attenuates gastrointestinal secretion and motility via cholinergic signaling in rat colonic mucosal preparations.
    Neurogastroenterol Motil. 2018 Oct 12:e13479. doi: 10.1111/nmo.13479.
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28. AGUILAR-AGUILAR E, Marcos-Pasero H, de la Iglesia R, Espinosa-Salinas I, et al
    Characteristics and determinants of dietary intake and physical activity in a group of patients with multiple chemical sensitivity.
    Endocrinol Diabetes Nutr. 2018 Oct 8. pii: S2530-0164(18)30193.
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29. HAN CJ, Jarrett ME, Cain KC, Jun S, et al
    Association of Fatigue With TPH2 Genetic Polymorphisms in Women With Irritable Bowel Syndrome.
    Biol Res Nurs. 2018 Oct 11:1099800418806055. doi: 10.1177/1099800418806055.
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30. CHUN E, Yoon S, Parveen A, Jin M, et al
    Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model.
    Nutrients. 2018;10.
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31. MANNING LP, Biesiekierski JR
    Use of dietary interventions for functional gastrointestinal disorders.
    Curr Opin Pharmacol. 2018;43:132-138.
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32. YIANNAKOU Y, Agrawal A, Allen PB, Arebi N, et al
    UK clinical experience up to 52 weeks with linaclotide for irritable bowel syndrome with constipation.
    Therap Adv Gastroenterol. 2018;11:1756284818798791.
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33. COBOS C, Bansal PS, Jones L, Wangchuk P, et al
    Engineering of an Anti-Inflammatory Peptide Based on the Disulfide-Rich Linaclotide Scaffold.
    Biomedicines. 2018;6.
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34. DOGAN B, Belcher-Timme HF, Dogan EI, Jiang ZD, et al
    Evaluation of Escherichia coli pathotypes associated with Irritable Bowel Syndrome.
    FEMS Microbiol Lett. 2018 Oct 8. pii: 5123711. doi: 10.1093.
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35. SODERQUIST F, Sundberg I, Ramklint M, Widerstrom R, et al
    The Relationship Between Daytime Salivary Melatonin and Gastrointestinal Symptoms in Young Adults Seeking Psychiatric Care.
    Psychosom Med. 2018 Oct 6. doi: 10.1097/PSY.0000000000000644.
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36. SHULMAN RJ, Ohman L, Stridsberg M, Cain K, et al
    Evidence of increased fecal granins in children with irritable bowel syndrome and correlates with symptoms.
    Neurogastroenterol Motil. 2018 Oct 9:e13486. doi: 10.1111/nmo.13486.
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37. GONZALEZ-ARENAS NR, Villalobos G, Vargas-Sanchez GB, Avalos-Galarza CA, et al
    Is the genetic variability of Cathepsin B important in the pathogenesis of Blastocystis spp.?
    Parasitol Res. 2018 Oct 8. pii: 10.1007/s00436-018-6103.
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38. REESE I, Schafer C, Kleine-Tebbe J, Ahrens B, et al
    Non-celiac gluten/wheat sensitivity (NCGS)-a currently undefined disorder without validated diagnostic criteria and of unknown prevalence: Position statement of the task force on food allergy of the German Society of Allergology and Clinical Immunolog
    Allergo J Int. 2018;27:147-151.
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39. OLDEN KW, Chey WD, Shringarpure R, Nicandro JP, et al
    Alosetron versus traditional pharmacotherapy in clinical practice: effects on resource use, health-related quality of life, safety and symptom improvement in women with severe diarrhea-predominant irritable bowel syndrome.
    Curr Med Res Opin. 2018 Oct 8:1-29. doi: 10.1080/03007995.2018.1533456.
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40. PAULS RN, Max JB
    Symptoms and dietary practices of irritable bowel syndrome patients compared to controls: results of a United States National survey.
    Minerva Gastroenterol Dietol. 2018 Oct 2. pii: S1121-421X.18.02518.
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41. OSADCHIY V, Martin CR, Mayer EA
    The Gut-Brain Axis and the Microbiome: Mechanisms and Clinical Implications.
    Clin Gastroenterol Hepatol. 2018 Oct 4. pii: S1542-3565(18)31081.
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42. MENYS A, Saliakellis E, Borrelli O, Thapar N, et al
    The evolution of magnetic resonance enterography in the assessment of motility disorders in children.
    Eur J Radiol. 2018;107:105-110.
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43. WEN W, Zhang H, Shen J, Wei L, et al
    Fecal microbiota transplantation for patients with irritable bowel syndrome: A meta-analysis protocol.
    Medicine (Baltimore). 2018;97:e12661.
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44. RAWLA P, Sunkara T, Raj JP
    Updated review of current pharmacological and non-pharmacological management of irritable bowel syndrome.
    Life Sci. 2018 Oct 2. pii: S0024-3205(18)30618-0. doi: 10.1016/j.lfs.2018.
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45. SAHIN-ERYILMAZ G, Basak K, Cakir-Madenci O, Koc H, et al
    Relationship between irritable bowel syndrome and plasma and tissue ghrelin levels.
    Turk J Gastroenterol. 2018 Oct 5. doi: 10.5152/tjg.2018.17593.
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46. CARD T, Enck P, Barbara G, Boeckxstaens GE, et al
    Post-infectious IBS: Defining its clinical features and prognosis using an internet-based survey.
    United European Gastroenterol J. 2018;6:1245-1253.
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47. LIN MJ, Yu BP
    Upregulation of the high-affinity choline transporter in colon relieves stress-induced hyperalgesia.
    J Pain Res. 2018;11:1971-1982.
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48. NG QX, Soh AYS, Loke W, Lim DY, et al
    The role of inflammation in irritable bowel syndrome (IBS).
    J Inflamm Res. 2018;11:345-349.
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49. CHANG C
    Short-course therapy for diarrhea-predominant irritable bowel syndrome: understanding the mechanism, impact on gut microbiota, and safety and tolerability of rifaximin.
    Clin Exp Gastroenterol. 2018;11:335-345.
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50. RUMSEY P, Waseem M, Pei LX, Geng H, et al
    Acupuncture for irritable bowel syndrome: study protocol for a multicenter randomized controlled trial.
    Trials. 2018;19:529.
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51. WEERTS ZZRM, Keszthelyi D, Vork L, Aendekerk NCP, et al
    A Novel Ileocolonic Release Peppermint Oil Capsule for Treatment of Irritable Bowel Syndrome: A Phase I Study in Healthy Volunteers.
    Adv Ther. 2018 Oct 4. pii: 10.1007/s12325-018-0802.
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52. GRUNDY L, Harrington AM, Castro J, Garcia-Caraballo S, et al
    Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction.
    JCI Insight. 2018;3.
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53. BOULETE IM, Thadi A, Beaufrand C, Patwa V, et al
    Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models.
    World J Gastroenterol. 2018;24:1888-1900.
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54. SOLAR I, Santos LAO, Yamashita LM, Barret JS, et al
    Irritable bowel syndrome: associations between FODMAPS intake, problematic foods, adiposity, and gastrointestinal symptoms.
    Eur J Clin Nutr. 2018 Oct 16. pii: 10.1038/s41430-018-0331.
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55. PENG Y, You H, Chen X, Chen Y, et al
    Effect of electroacupuncture at homotopic and heterotopic acupoints on abdominal pain in patients with irritable bowel syndrome: study protocol for a randomized controlled trial.
    Trials. 2018;19:559.
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56. SCHOMACKER ML, Hansen KE, Ramlau-Hansen CH, Forman A, et al
    Is endometriosis associated with irritable bowel syndrome? A cross-sectional study.
    Eur J Obstet Gynecol Reprod Biol. 2018;231:65-69.
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57. LI J, Cui H, Cai Y, Lin J, et al
    Tong-Xie-Yao-Fang Regulates 5-HT Level in Diarrhea Predominant Irritable Bowel Syndrome Through Gut Microbiota Modulation.
    Front Pharmacol. 2018;9:1110.
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58. REJ A, Aziz I, Sanders DS
    Breaking bread!
    Proc Nutr Soc. 2018 Oct 16:1-8. doi: 10.1017/S0029665118002549.
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59. LLANOS-CHEA A, Fasano A
    Gluten and Functional Abdominal Pain Disorders in Children.
    Nutrients. 2018;10.
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60. HEBBELSTRUP JENSEN B, Adler Sorensen C, Hebbelstrup Rye Rasmussen S, Rejkjaer Holm D, et al
    Characterization of Diarrheagenic Enteroaggregative Escherichia coli in Danish Adults-Antibiotic Treatment Does Not Reduce Duration of Diarrhea.
    Front Cell Infect Microbiol. 2018;8:306.
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61. GHANDI F, Sadeghi A, Bakhtyari M, Imani S, et al
    Comparing the Efficacy of Mindfulness-Based Stress Reduction Therapy with Emotion Regulation Treatment on Quality of Life and Symptoms of Irritable Bowel Syndrome.
    Iran J Psychiatry. 2018;13:175-183.
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62. POURMASOUMI M, Ghiasvand R, Darvishi L, Hadi A, et al
    Comparison and assessment of flixweed and fig effects on irritable bowel syndrome with predominant constipation: A single-blind randomized clinical trial.
    Explore (NY). 2018 Sep 11. pii: S1550-8307(18)30187.
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63. CICEK Y, Durakoglugil ME, Rakici H, Balcioglu AS, et al
    The effect of epicardial adipose tissue thickness with irritable bowel syndrome.
    J Pak Med Assoc. 2018;68:1456-1460.
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64. EK M, Roth B, Nilsson PM, Ohlsson B, et al
    Characteristics of endometriosis: A case-cohort study showing elevated IgG titers against the TSH receptor (TRAb) and mental comorbidity.
    Eur J Obstet Gynecol Reprod Biol. 2018;231:8-14.
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65. NGUYEN L
    Complementary and Alternative Medicine for the Management of Irritable Bowel Syndrome.
    Gastroenterol Hepatol (N Y). 2018;14:536-538.
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66. LEE SH, Cho DY, Lee SH, Han KS, et al
    A Randomized Clinical Trial of Synbiotics in Irritable Bowel Syndrome: Dose-Dependent Effects on Gastrointestinal Symptoms and Fatigue.
    Korean J Fam Med. 2018 Oct 26. pii: kjfm.17.0064. doi: 10.4082/kjfm.17.0064.
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67. HETTERICH L, Mack I, Giel KE, Zipfel S, et al
    An update on gastrointestinal disturbances in eating disorders.
    Mol Cell Endocrinol. 2018 Oct 22. pii: S0303-7207(18)30311.
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68. BAK A, Ashford M, Brayden DJ
    Local delivery of macromolecules to treat diseases associated with the colon.
    Adv Drug Deliv Rev. 2018 Oct 22. pii: S0169-409X(18)30259.
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69. READE S, Williams JM, Aggio R, Duckworth CA, et al
    Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice.
    FASEB J. 2018 Oct 25:fj201800076RR. doi: 10.1096/fj.201800076.
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70. EL-AYACHE N, Galligan JJ
    5-HT3 receptor signaling in serotonin transporter knockout rats: a female sex specific animal model of visceral hypersensitivity.
    Am J Physiol Gastrointest Liver Physiol. 2018.
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71. WALLACE JL
    Nitric Oxide in the Gastrointestinal Tract: Opportunities for Drug Development.
    Br J Pharmacol. 2018 Oct 24. doi: 10.1111/bph.14527.
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72. MUDYANADZO TA, Hauzaree C, Yerokhina O, Architha NN, et al
    Irritable Bowel Syndrome and Depression: A Shared Pathogenesis.
    Cureus. 2018;10:e3178.
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73. FARMER AD, Ruffle JK, Hobson AR
    Linaclotide increases cecal pH, accelerates colonic transit, and increases colonic motility in irritable bowel syndrome with constipation.
    Neurogastroenterol Motil. 2018 Oct 23:e13492. doi: 10.1111/nmo.13492.
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74. PORIKA SK, Veligandla KC, Muni SK, Acharya S, et al
    Real-World, Non-Interventional, Observational Study to Evaluate Effectiveness and Tolerability of Acotiamide Hydrochloride Hydrate in Treatment of Functional Dyspepsia.
    Adv Ther. 2018 Oct 22. pii: 10.1007/s12325-018-0814.
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75. HOU Q, Huang Y, Zhang C, Zhu S, et al
    MicroRNA-200a Targets Cannabinoid Receptor 1 and Serotonin Transporter to Increase Visceral Hyperalgesia in Diarrhea-predominant Irritable Bowel Syndrome Rats.
    J Neurogastroenterol Motil. 2018;24:656-668.
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76. LIN MJ, Yu BP
    Role of High-affinity Choline Transporter 1 in Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome.
    J Neurogastroenterol Motil. 2018;24:643-655.
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77. SHUKLA R, Ghoshal U, Ranjan P, Ghoshal UC, et al
    Expression of Toll-like Receptors, Pro-, and Anti-inflammatory Cytokines in Relation to Gut Microbiota in Irritable Bowel Syndrome: The Evidence for Its Micro-organic Basis.
    J Neurogastroenterol Motil. 2018;24:628-642.
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78. KIM YS, Kim N
    Sex-Gender Differences in Irritable Bowel Syndrome.
    J Neurogastroenterol Motil. 2018;24:544-558.
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79. KIM HJ
    Do Toll-like Receptors Play a New Role as a Biomarker of Irritable Bowel Syndrome?
    J Neurogastroenterol Motil. 2018;24:510-511.
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80. TRIVIC I, Hojsak I
    Initial Diagnosis of Functional Gastrointestinal Disorders in Children Increases a Chance for Resolution of Symptoms.
    Pediatr Gastroenterol Hepatol Nutr. 2018;21:264-270.
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81. NASSAR Y, Richter S
    Gastroparesis in Non-Diabetics: Associated Conditions and Possible Risk Factors.
    Gastroenterology Res. 2018;11:340-345.
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82. CODONER-FRANCH P, Gombert M
    Circadian rhythms in the pathogenesis of gastrointestinal diseases.
    World J Gastroenterol. 2018;24:4297-4303.
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83. DONG Y, Berens S, Eich W, Schaefert R, et al
    Is body mass index associated with symptom severity and health-related quality of life in irritable bowel syndrome? A cross-sectional study.
    BMJ Open. 2018;8:e019453.
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84. DOLLINGER MM, Behl S, Fleig WE
    Early Detection of Colorectal Cancer: a Multi-Center Pre-Clinical Case Cohort Study for Validation of a Combined DNA Stool Test.
    Clin Lab. 2018;64:1719-1730.
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85. DAYANANDA P, Wilcox MH
    Irritable bowel syndrome following Clostridium difficile infection.
    Curr Opin Gastroenterol. 2018 Oct 17. doi: 10.1097/MOG.0000000000000490.
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86. LI Y
    Synaptic Plasticity and Synchrony in the Anterior Cingulate Cortex Circuitry: A Neural Network Approach to Causality of Chronic Visceral Pain and Associated Cognitive Deficits.
    Adv Neurobiol. 2018;21:219-245.
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87. FETTUCCIARI K, Macchioni L, Davidescu M, Scarpelli P, et al
    Clostridium difficile toxin B induces senescence in enteric glial cells: A potential new mechanism of Clostridium difficile pathogenesis.
    Biochim Biophys Acta Mol Cell Res. 2018;1865:1945-1958.
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88. MUIR JG, Varney JE, Ajamian M, Gibson PR, et al
    Gluten-free and low-FODMAP sourdoughs for patients with coeliac disease and irritable bowel syndrome: A clinical perspective.
    Int J Food Microbiol. 2018;290:237-246.
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89. RAUFMAN JP, Metry M, Felton J, Cheng K, et al
    A (19)F magnetic resonance imaging-based diagnostic test for bile acid diarrhea.
    MAGMA. 2018 Nov 1. pii: 10.1007/s10334-018-0713.
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90. TORNBLOM H, Goosey R, Wiseman G, Baker S, et al
    Understanding symptom burden and attitudes to irritable bowel syndrome with diarrhoea: Results from patient and healthcare professional surveys.
    United European Gastroenterol J. 2018;6:1417-1427.
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91. DI CIAULA A, Portincasa P, Maes N, Albert A, et al
    Efficacy of bio-optimized extracts of turmeric and essential fennel oil on the quality of life in patients with irritable bowel syndrome.
    Ann Gastroenterol. 2018;31:685-691.
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92. DE BORTOLI N, Tolone S, Frazzoni M, Martinucci I, et al
    Gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome: common overlapping gastrointestinal disorders.
    Ann Gastroenterol. 2018;31:639-648.
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93. IHEKWEAZU FD, Versalovic J
    Development of the Pediatric Gut Microbiome: Impact on Health and Disease.
    Am J Med Sci. 2018;356:413-423.
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94. SINHA T, Vich Vila A, Garmaeva S, Jankipersadsing SA, et al
    Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles.
    Gut Microbes. 2018 Oct 29:1-9. doi: 10.1080/19490976.2018.1528822.
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95. STRAUBE A, Muller H, Stiegelbauer V, Frauwallner A, et al
    [Migraine prophylaxis with a probiotic. Results of an uncontrolled observational study with 1,020 patients].
    MMW Fortschr Med. 2018;160.
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96. RAFFAELLI R, Garzon S, Baggio S, Genna M, et al
    Mesenteric vascular and nerve sparing surgery in laparoscopic segmental intestinal resection for deep infiltrating endometriosis.
    Eur J Obstet Gynecol Reprod Biol. 2018;231:214-219.
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97. RUSSELL J, Mohammadi E, Ligon CO, Johnson AC, et al
    Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity.
    J Pharmacol Exp Ther. 2018 Nov 9. pii: jpet.118.252973.
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