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Amedeo Prize 2008
The 21 Finalists


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Articles published in J Biol Chem

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    April 2008
  1. BURMAN JD , Leung E, Atkins KL, O'Seaghdha MN, et al
    Interaction of human complement with SBI, a staphylococcal immunoglobulin-binding protein: Indications of a novel mechanism of complement evasion by Staphylococcus aureus.
    J Biol Chem. 2008;.
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  2. SIROY A , Mailaender C, Harder D, Koerber S, et al
    Rv1698 of Mycobacterium tuberculosis represents a new class of channel-forming outer membrane proteins.
    J Biol Chem. 2008;.
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  3. LIGHTBODY KL , Ilghari D, Waters LC, Carey G, et al
    Molecular features governing the stability and specificity of functional complex formation by M. tuberculosis CFP-10/ESAT-6 family proteins.
    J Biol Chem. 2008;.
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  4. KUMAR A , Deshane JS, Crossman DK, Bolisetty S, et al
    Heme oxygenase-1 derived carbon monoxide induces the mycobacterium tuberculosis dormancy regulon.
    J Biol Chem. 2008;.
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  5. MALAGA W , Constant P, Euphrasie D, Cataldi A, et al
    Deciphering the genetic bases of the structural diversity of phenolic glycolipids in strains of the Mycobacterium tuberculosis complex.
    J Biol Chem. 2008;.
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  6. BENTLEY ML , Lamb EC, McCafferty DG
    Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus.
    J Biol Chem. 2008;.
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    March 2008
  7. JORGENSEN AD , Nohr J, Kastrup JS, Gajhede M, et al
    Small angle X-ray studies reveal that aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution.
    J Biol Chem. 2008;.
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  8. LEMAIRE S , Fuda C, Van Bambeke F, Tulkens PM, et al
    Restoration of susceptibility of methicillin-resistant staphylococcus aureus (MRSA) to beta -lactam antibiotics by acidic pH: Role of penicillin-binding protein 2A (PBP 2A).
    J Biol Chem. 2008;.
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  9. KOGA T , Lim JH, Jono H, Ha UH, et al
    Tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling.
    J Biol Chem. 2008;.
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  10. BELCHEVA A , Golemi-Kotra D
    A close-up view of the VraSR two-component system:A mediator of staphylococcus aureus response to cell wall damage.
    J Biol Chem. 2008;.
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    February 2008
  11. JIA SH , Parodo J, Kapus A, Rotstein OD, et al
    Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8.
    J Biol Chem. 2008;283:5402-13.
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  12. BHAMIDI S , Scherman MS, Rithner CD, Prenni JE, et al
    The identification and location of succinyl residues and the characterization of the interior arabinan region allows for a model of the compete primary structure of mycobacterium tuberculosis mycolyl arabinogalactan.
    J Biol Chem. 2008;.
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  13. YOSHIDA Y , Yang J, Peaker PE, Kato H, et al
    Molecular and antigenic characterization of a streptococcus oralis coaggregation receptor polysaccharide by carbohydrate engineering in S. gordonii.
    J Biol Chem. 2008;.
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  14. NOOR S , Goldfine H, Tucker DE, Suram S, et al
    Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2.
    J Biol Chem. 2008;283:4744-55.
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  15. JARBOE LR , Hyduke DR, Tran LM, Chou KJ, et al
    Determination of the Escherichia coli S-nitrosoglutathione response network using integrated biochemical and systems analysis.
    J Biol Chem. 2008;283:5148-57.
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    January 2008
  16. MILLE C , Bobrowicz P, Trinel PA, Li H, et al
    Identification of a new family of genes involved in beta-1,2 mannosylation of glycans in Pichia pastoris and Candida albicans.
    J Biol Chem. 2008;.
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  17. GAUNTLETT JC , Gebhard S, Keis S, Manson JM, et al
    Molecular analysis of BcrR: A membrane-bound bacitracin sensor and DNA-binding protein from enterococcus faecalis.
    J Biol Chem. 2008;.
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  18. ISHII K , Hamamoto H, Kamimura M, Sekimizu K, et al
    Activation of the silkworm cytokine by bacterial and fungal cell wall components via a reactive oxygen species-triggered mechanism.
    J Biol Chem. 2008;283:2185-91.
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  19. THAKUR M , Chaba R, Mondal AK, Chakraborti PK, et al
    Inter-domain interaction reconstitutes the functionality of PknA, a eukaryotic-type Ser/Thr kinase from mycobacterium tuberculosis.
    J Biol Chem. 2008;.
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  20. BADARAU A , Shi Q, Chow JW, Zajicek J, et al
    Aminoglycoside 2"-phosphotransferase type IIIa from enterococcus.
    J Biol Chem. 2008;.
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  21. HIFUMI E , Morihara F, Hatiuchi K, Okuda T, et al
    Catalytic features and eradication ability of antibody light-chain UA15-L against Helicobacter pylori.
    J Biol Chem. 2008;283:899-907.
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  22. LIU M , Tanaka WN, Zhu H, Xie G, et al
    Direct hemin transfer from IsdA to IsdC in the Isd heme acquisition system of staphylococcus aureus.
    J Biol Chem. 2008;.
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  23. GILLEN CM , Courtney HS, Schulze K, Rohde M, et al
    Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete.
    J Biol Chem. 2008;.
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    December 2007
  24. PALAND N , Bohme L, Gurumurthy RK, Maurer A, et al
    Reduced display of tumor necrosis factor receptor I at the host cell surface supports infection with Chlamydia trachomatis.
    J Biol Chem. 2007;.
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  25. TERAO Y , Mori Y, Yamaguchi M, Shimizu Y, et al
    Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity.
    J Biol Chem. 2007;.
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  26. BERG DT , Gupta A, Richardson MA, O'Brien LA, et al
    Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11.
    J Biol Chem. 2007;282:36837-44.
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  27. OUELLET H , Podust LM, Ortiz de Montellano PR
    Mycobacterium tuberculosis CYP130: Crystal structure, biophysical characterization, and interactions with antifungal azole drugs.
    J Biol Chem. 2007;.
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  28. WERTHER T , Spinka M, Tittmann K, Schutz A, et al
    Amino acids allosterically regulate the thiamine diphosphate-dependent alpha -keto acid decarboxylase from mycobacterium tuberculosis.
    J Biol Chem. 2007;.
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  29. SHAO W , Yeretssian G, Doiron K, Hussain SN, et al
    The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock.
    J Biol Chem. 2007;282:36321-9.
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  30. HERAS B , Kurz M, Jarrott R, Shouldice SR, et al
    Staphylococcus aureus DSBA does not have a destabilising disulfide: A new paradigm for bacterial oxidative folding.
    J Biol Chem. 2007;.
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  31. LLOYD AJ , Gilbey AM, Blewett AM, Pascale GD, et al
    Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
    J Biol Chem. 2007;.
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  32. METCALFE CL , Macdonald IK, Murphy EJ, Brown KA, et al
    The tuberculosis prodrug isoniazid bound to activating peroxidases.
    J Biol Chem. 2007;.
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    November 2007
  33. JOB V , Carapito R, Vernet T, Dessen A, et al
    Common alterations in PBP1a from resistant streptococcus pneumoniae decrease its reactivity towards beta -lactams: Structural insights.
    J Biol Chem. 2007;.
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  34. FU Q , Figuera-Losada M, Ploplis VA, Cnudde S, et al
    The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen Kringle-2 domain.
    J Biol Chem. 2007;.
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  35. SUN YH , Rolan HG, Tsolis RM
    Injection of flagellin into the host cell cytosol by Salmonella enterica serotype Typhimurium.
    J Biol Chem. 2007;282:33897-901.
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  36. DUONG N , Osborne S, Bustamante VH, Tomljenovic AM, et al
    Thermosensing coordinates a cis-regulatory module for transcriptional activation of the intracellular virulence system in Salmonella enterica serovar Typhimurium.
    J Biol Chem. 2007;282:34077-84.
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  37. TROSKY JE , Li Y, Mukherjee S, Keitany G, et al
    VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases.
    J Biol Chem. 2007;282:34299-305.
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  38. LIU H , Jiravanichpaisal P, Cerenius L, Lee BL, et al
    Phenoloxidase is an important component of the defense against Aeromonas hydrophila Infection in a crustacean, Pacifastacus leniusculus.
    J Biol Chem. 2007;282:33593-8.
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  39. LAVAL F , Haites R, Movahedzadeh F, Lemassu A, et al
    Investigating the function of the putative mycolic-acid methyltransferase UmaA : Divergence between the mycobacterium smegmatis and mycobacterium tuberculosis proteins.
    J Biol Chem. 2007;.
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  40. MAC TT , Hacht AV, Hung KC, Dutton RJ, et al
    Insight into disulfide bond catalysis in Chlamydia from the structure and function of DsbH - a novel oxidoreductase.
    J Biol Chem. 2007;.
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  41. LIDEN A , van Wieringen T, Lannergard J, Kassner A, et al
    A secreted collagen and fibronectin-binding streptococcal protein modulates cell-mediated collagen gel contraction and interstitial fluid pressure.
    J Biol Chem. 2007;.
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  42. BOWDEN MG , Heuck AP, Ponnuraj K, Kolosova E, et al
    Evidence for the "Dock, Lock and Latch" ligand binding mechanism of the staphylococcal MSCRAMM SdrG.
    J Biol Chem. 2007;.
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    October 2007
  43. POLTERMANN S , Kunert A, von der Heide M, Eck R, et al
    Gpm1p is a factor H, FHL-1 and plasminogen-binding surface protein of Candida albicans.
    J Biol Chem. 2007;.
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  44. YANG Y , Yin C, Pandey A, Abbott D, et al
    NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.
    J Biol Chem. 2007;.
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  45. NAGATA M , Kaito C, Sekimizu K
    Phosphodiesterase activity of CvfA is required for virulence in Staphylococcus aureus.
    J Biol Chem. 2007;.
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  46. KING-SCOTT J , Nowak E, Mylonas E, Panjikar S, et al
    The structure of a full-length response regulator from mycobacterium tuberculosis in a stabilised 3D domain-swapped, activated state.
    J Biol Chem. 2007;.
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  47. BROWN MD , Bry L, Li Z, Sacks DB, et al
    IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1, and Cdc42.
    J Biol Chem. 2007;282:30265-72.
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  48. FAN X , Liu Y, Smith D, Konermann L, et al
    Diversity of penicillin-binding proteins: Resistance factor FmtA of Staphylococcus aureus.
    J Biol Chem. 2007;.
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  49. KOTSYFAKIS M , Karim S, Andersen JF, Mather TN, et al
    Selective cysteine protease inhibition contributes to blood-feeding success of the tick Ixodes scapularis.
    J Biol Chem. 2007;282:29256-63.
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  50. HERVAS-AGUILAR A , Rodriguez JM, Tilburn J, Arst HN Jr, et al
    Evidence for the direct involvement of the proteasome in the proteolytic processing of the Aspergillus nidulans zinc-finger transcription factor PACC.
    J Biol Chem. 2007;.
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    September 2007
  51. GARSCHA U , Jerneren F, Chung D, Keller NP, et al
    Identification of dioxygenases required for aspergillus development: Studies of products, stereochemistry and the reaction mechanism.
    J Biol Chem. 2007;.
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  52. MCNALLY DJ , Lamoureux MP, Karlyshev AV, Fiori LM, et al
    Commonality and biosynthesis of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni.
    J Biol Chem. 2007;282:28566-76.
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  53. BEISSWENGER C , Coyne CB, Shchepetov M, Weiser JN, et al
    Role of p38 MAP kinase and transforming growth factor-beta signaling in transepithelial migration of invasive bacterial pathogens.
    J Biol Chem. 2007;282:28700-8.
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  54. NICKERSON NN , Prasad L, Jacob L, Delbaere LT, et al
    Activation of the SspA-serine protease zymogen of Staphylococcus aureus proceeds through unique variations of a trypsinogen-like mechanism, and is dependent on both autocatalytic and metalloprotease-specific processing.
    J Biol Chem. 2007;.
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  55. WU F , Vij N, Roberts L, Lopez-Briones S, et al
    A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response.
    J Biol Chem. 2007;282:26409-17.
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  56. MEYER V , Damveld RA, Arentshorst M, Stahl U, et al
    Survival in the presence of antifungals: Genome-wide expression profiling of aspergillus niger in response to sub-lethal concentrations of caspofungin and fenpropimorph.
    J Biol Chem. 2007;.
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    August 2007
  57. BHATNAGAR S , Schorey JS
    Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory.
    J Biol Chem. 2007;282:25779-89.
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  58. YANG L , Bae JS, Manithody C, Rezaie AR, et al
    Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1.
    J Biol Chem. 2007;282:25493-500.
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  59. BURTON RL , Chen S, Xu XL, Grant GA, et al
    A novel mechanism for substrate inhibition in mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase.
    J Biol Chem. 2007;.
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  60. HAMMEL M , Sfyroera G, Pyrpassopoulos S, Ricklin D, et al
    Characterization of Ehp: A secreted complement inhibitory protein from Staphylococcus aureus.
    J Biol Chem. 2007;.
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  61. RAN Y , Zhu H, Liu M, Fabian M, et al
    Bis-methionine ligation to heme iron in the streptococcal cell surface protein SHP facilitates rapid hemin transfer to HtsA of the HtsABC transporter.
    J Biol Chem. 2007;.
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  62. HAKANSSON AP , Smith AW
    Enzymatic characterization of dihydrolipoamide dehydrogenase from Streptococcus pneumoniae harboring its own substrate.
    J Biol Chem. 2007;.
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    July 2007
  63. GRIGG JC , Vermeiren CL, Heinrichs DE, Murphy ME, et al
    Heme coordination by staphylococcus aureus IsdE.
    J Biol Chem. 2007;.
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  64. SCHNITGER AK , Kafatos FC, Osta MA
    The melanization reaction is not required for survival of Anopheles gambiae mosquitoes after bacterial infections.
    J Biol Chem. 2007;282:21884-8.
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  65. LEWIS AL , Cao H, Patel SK, Diaz S, et al
    NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharides in Group B Streptococcus.
    J Biol Chem. 2007;.
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  66. MAINARDI JL , Hugonnet JE, Rusconi F, Fourgeaud M, et al
    Unexpected Inhibition of Peptidoglycan L,D-Transpeptidase from Enterococcus faecium by the beta -lactam Imipenem.
    J Biol Chem. 2007;.
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  67. CHEN Y , Anderson DE, Rajagopalan M, Erickson HP, et al
    Assembly dynamics of mycobacterium tuberculosis FtsZ.
    J Biol Chem. 2007;.
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  68. SHIRYAEV SA , Remacle AG, Ratnikov BI, Nelson NA, et al
    Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
    J Biol Chem. 2007;282:20847-53.
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  69. REIGSTAD CS , Hultgren SJ, Gordon JI
    Functional genomic studies of uropathogenic Escherichia coli and host urothelial cells when intracellular bacterial communities are assembled.
    J Biol Chem. 2007;282:21259-67.
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  70. MCNEIL HP , Adachi R, Stevens RL
    Mast cell-restricted tryptases: structure and function in inflammation and pathogen defense.
    J Biol Chem. 2007;282:20785-9.
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  71. THAKURDAS SM , Melicoff E, Sansores-Garcia L, Moreira DC, et al
    The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections.
    J Biol Chem. 2007;282:20809-15.
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  72. STADTHAGEN G , Sambou T, Guerin M, Barilone N, et al
    Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in mycobacterium tuberculosis.
    J Biol Chem. 2007;.
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  73. HOFFMANN M , Hornung E, Busch S, Kassner N, et al
    A small membrane-peripheral region close to the active center determines regioselectivity of membrane bound fatty acid desaturases from aspergillus nidulans.
    J Biol Chem. 2007;.
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  74. STAUFF DL , Torres VJ, Skaar EP
    Signaling and DNA binding activities of the staphylococcus aureus HssR-HssS two-component system required for heme sensing.
    J Biol Chem. 2007;.
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  75. THON M , Al-Abdallah Q, Hortschansky P, Brakhage AA, et al
    The thioredoxin system of the filamentous fungus aspergillus nidulans: Impact on development and oxidative stress response.
    J Biol Chem. 2007;.
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  76. DE WEERD NA , Samarajiwa SA, Hertzog PJ
    Type I interferon receptors: biochemistry and biological functions.
    J Biol Chem. 2007;282:20053-7.
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  77. ZIMNICKA AM , Maryon EB, Kaplan JH
    Human copper transporter hCTR1 mediates basolateral uptake of copper into enterocytes: Implications for copper homeostasis.
    J Biol Chem. 2007;.
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  78. LAMBERT C , Li J, Jonscher K, Yang TC, et al
    Acrolein inhibits cytokine gene expression by alkylating cysteine and arginine residues in the NF-kappaB1 DNA binding domain.
    J Biol Chem. 2007;282:19666-75.
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  79. MEENAN NA , Visai L, Valtulina V, Schwarz-Linek U, et al
    The tandem beta -zipper model defines high affinity fibronectin-binding repeats within Staphylococcus aureus FnBPA.
    J Biol Chem. 2007;.
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    June 2007
  80. FRANCHI L , Kanneganti TD, Dubyak GR, Nunez G, et al
    Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria.
    J Biol Chem. 2007;282:18810-8.
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  81. PILLINGER MH , Marjanovic N, Kim SY, Lee YC, et al
    Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation.
    J Biol Chem. 2007;282:18722-31.
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  82. WITTKOWSKI M , Mittelstadt J, Brandau S, Reiling N, et al
    Capsular arabinomannans from Mycobacterium avium with morphotype-specific structural differences but identical biological activity.
    J Biol Chem. 2007;282:19103-12.
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  83. REDDY MC , Palaninathan SK, Shetty ND, Owen JL, et al
    High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: Insights into the mechanism and specificity of this novel prokaryotic enzyme.
    J Biol Chem. 2007;.
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  84. SCHNELL R , Oehlmann W, Singh M, Schneider G, et al
    Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis: Crystal structures of the enzyme - alpha -aminoacrylate intermediate and an enzyme-inhibitor complex.
    J Biol Chem. 2007;.
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  85. PAHLMAN LI , Marx PF, Morgelin M, Lukomski S, et al
    Thrombin activatable fibrinolysis inhibitor binds to Streptococcus pyogenes by interacting with collagen-like surface proteins A and B.
    J Biol Chem. 2007;.
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  86. DUNFORD AJ , McLean KJ, Sabri M, Seward HE, et al
    Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1: Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.
    J Biol Chem. 2007;.
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    May 2007
  87. CLEMENTS A , Tull D, Jenney AW, Farn JL, et al
    Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides.
    J Biol Chem. 2007;282:15569-77.
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  88. LECUIT M , Sonnenburg JL, Cossart P, Gordon JI, et al
    Functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse model.
    J Biol Chem. 2007;282:15065-72.
    PubMed     Related articles    Abstract available


  89. HENRIKSSON LM , Unge T, Carlsson J, Aqvist J, et al
    Structures of mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate reductoisomerase provide new insights into catalysis.
    J Biol Chem. 2007;.
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  90. KHOO SK , Loll B, Chan WT, Shoeman RL, et al
    Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae.
    J Biol Chem. 2007;.
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  91. VEERMAN EC , Valentijn-Benz M, Nazmi K, Ruissen AL, et al
    Energy depletion protects candida albicans against antimicrobial peptides by rigidifying its cell membrane.
    J Biol Chem. 2007;.
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  92. BOTTOMLEY MJ , Muraglia E, Bazzo R, Carfi A, et al
    Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer.
    J Biol Chem. 2007;282:13592-600.
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  93. LU C , Egawa T, Wainwright LM, Poole RK, et al
    Structural and functional properties of a truncated hemoglobin from a food-borne pathogen Campylobacter jejuni.
    J Biol Chem. 2007;282:13627-36.
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  94. SHAO B , Lu M, Katz SC, Varley AW, et al
    A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen.
    J Biol Chem. 2007;282:13726-35.
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    April 2007
  95. ARRECUBIETA C , Lee MH, Macey A, Foster TJ, et al
    SdrF, a Staphylococcus epidermidis surface protein, binds type I collagen.
    J Biol Chem. 2007;.
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  96. MIALLAU L , Hunter WN, McSweeney SM, Leonard GA, et al
    Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism.
    J Biol Chem. 2007;.
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  97. DINKLA K , Nitsche-Schmitz DP, Barroso V, Reissmann S, et al
    Identification of a streptococcal octa-peptide motif involved in acute rheumatic fever.
    J Biol Chem. 2007;.
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  98. NITSCHE-SCHMITZ DP , Johansson HM, Sastalla I, Reissmann S, et al
    Group G streptococcal IgG-binding molecules fog and protein G have different impact on opsonization by C1q.
    J Biol Chem. 2007;.
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  99. AKOACHERE M , Squires RC, Nour AM, Angelov L, et al
    Identification of an in vivo inhibitor of Bacillus anthracis spore germination.
    J Biol Chem. 2007;282:12112-8.
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  100. LELLA RK , Sharma C
    EIS (enhanced intracellular survival) protein of mycobacterium tuberculosis disturbs the cross regulation of T-cells.
    J Biol Chem. 2007;.
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  101. MORGUNOVA E , Saller S, Haase I, Cushman M, et al
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