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Articles published in Cancer Res

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    January 2018
  1. LIU C, Nie D, Li J, Du X, et al
    Antitumor effects of blocking protein neddylation in T315I-BCR-ABL leukemia cells and leukemia stem cells.
    Cancer Res. 2018 Jan 10. pii: 0008-5472.CAN-17-1733.
    PubMed     Text format     Abstract available


    December 2017
  2. DE DOMINICI M, Porazzi P, Soliera AR, Mariani SA, et al
    Targeting CDK6 and BCL2 exploits the "MYB addiction" of Ph+ acute lymphoblastic leukemia.
    Cancer Res. 2017 Dec 12. pii: 0008-5472.CAN-17-2644.
    PubMed     Text format     Abstract available


  3. NOBREGA-PEREIRA S, Caiado F, Carvalho T, Matias I, et al
    VEGFR-2-mediated reprogramming of mitochondrial metabolism regulates the sensitivity of acute myeloid leukemia to chemotherapy.
    Cancer Res. 2017 Dec 11. pii: 0008-5472.CAN-17-1166.
    PubMed     Text format     Abstract available


    November 2017
  4. LE SOMMER S, Morrice N, Pesaresi M, Thompson D, et al
    Deficiency in protein tyrosine phosphatase PTP1B shortens lifespan and leads to development of acute leukemia.
    Cancer Res. 2017 Nov 9. pii: canres.0946.2017.
    PubMed     Text format     Abstract available


    October 2017
  5. BRUNER JK, Ma HS, Li L, Qin ACR, et al
    Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase-Driven Leukemias and Other Malignancies.
    Cancer Res. 2017;77:5554-5563.
    PubMed     Text format     Abstract available


  6. SABA NS, Wong DH, Tanios G, Iyer JR, et al
    MALT1 inhibition is efficacious in both naive and ibrutinib-resistant chronic lymphocytic leukemia.
    Cancer Res. 2017 Oct 9. pii: canres.2485.2017.
    PubMed     Text format     Abstract available


    September 2017
  7. DE GRANDIS M, Bardin F, Fauriat C, Zemmour C, et al
    JAM-C identifies Src family kinase-activated leukemia-initiating cells and predicts poor prognosis in acute myeloid leukemia.
    Cancer Res. 2017 Sep 28. pii: canres.1223.2017.
    PubMed     Text format     Abstract available


  8. JING W, Gershan JA, Holzhauer S, Weber J, et al
    T cells deficient in diacylglycerol kinase-zeta are resistant to PD-1 inhibition and help create persistent host immunity to leukemia.
    Cancer Res. 2017 Sep 15. pii: canres.1309.2017.
    PubMed     Text format     Abstract available


    August 2017
  9. ZHANG H, Means S, Schultz AR, Watanabe-Smith K, et al
    Unpaired Extracellular Cysteine Mutations of CSF3R Mediate Gain or Loss of Function.
    Cancer Res. 2017;77:4258-4267.
    PubMed     Text format     Abstract available


  10. HOU P, Wu C, Wang Y, Qi R, et al
    A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.
    Cancer Res. 2017;77:4402-4413.
    PubMed     Text format     Abstract available


    June 2017
  11. GREEN AM, Budagyan K, Hayer KE, Reed MA, et al
    Cytosine deaminase APOBEC3A sensitizes leukemia cells to inhibition of the DNA replication checkpoint.
    Cancer Res. 2017 Jun 27. pii: canres.3394.2016.
    PubMed     Text format     Abstract available


  12. TAMAI H, Yamaguchi H, Miyake K, Takatori M, et al
    Amlexanox downregulates S100A6 to sensitize KMT2A/AFF1-positive acute lymphoblastic leukemia to TNF-alpha treatment.
    Cancer Res. 2017 Jun 23. pii: canres.2974.2016.
    PubMed     Text format     Abstract available


  13. RODRIGUEZ-HERNANDEZ G, Hauer J, Martin-Lorenzo A, Schafer D, et al
    Infection exposure promotes ETV6-RUNX1 precursor B cell leukemia via impaired H3K4 demethylases.
    Cancer Res. 2017 Jun 19. pii: canres.0701.2017.
    PubMed     Text format     Abstract available


    April 2017

  14. Correction: Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia.
    Cancer Res. 2017;77:2174.
    PubMed     Text format    


  15. DRENBERG CD, Gibson AA, Pounds SB, Shi L, et al
    OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.
    Cancer Res. 2017;77:2102-2111.
    PubMed     Text format     Abstract available


  16. VALERIO DG, Xu H, Chen CW, Hoshii T, et al
    Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.
    Cancer Res. 2017;77:1753-1762.
    PubMed     Text format     Abstract available


    February 2017
  17. DE SMITH AJ, Kaur M, Gonseth S, Endicott AA, et al
    Correlates of prenatal and early-life tobacco smoke exposure and frequency of common gene deletions in childhood acute lymphoblastic leukemia.
    Cancer Res. 2017 Feb 15. pii: canres.2571.2016.
    PubMed     Text format     Abstract available


    January 2017
  18. TABE Y, Yamamoto S, Saitoh K, Sekihara K, et al
    Survival of acute monocytic leukemia cells is driven by fatty acid oxidation-mediated activation of AMPK in bone marrow adipocytes.
    Cancer Res. 2017 Jan 20. pii: canres.1645.2016.
    PubMed     Text format     Abstract available


  19. GAYMES TJ, Mohamedali A, Eiliazadeh A, Darling D, et al
    FLT3 and JAK2 mutations in acute myeloid leukemia promote inter-chromosomal homologous recombination and the potential for copy neutral loss of heterozygosity (CN-LOH).
    Cancer Res. 2017 Jan 20. pii: canres.1678.2016.
    PubMed     Text format     Abstract available


  20. EISFELD AK, Kohlschmidt J, Mrozek K, Volinia S, et al
    Mutational Landscape and Gene Expression Patterns in Adult Acute Myeloid Leukemias with Monosomy 7 as a Sole Abnormality.
    Cancer Res. 2017;77:207-218.
    PubMed     Text format     Abstract available


    December 2016
  21. SILVERBUSH D, Grosskurth S, Wang D, Powell F, et al
    Cell-specific computational modeling of the PIM pathway in acute myeloid leukemia.
    Cancer Res. 2016 Dec 13. pii: canres.1578.2016.
    PubMed     Text format     Abstract available


    November 2016
  22. ABDUL-AZIZ A, Shafat M, Mehta T, Di Palma F, et al
    MIF-induced stromal PKCbeta/IL8 is essential in human acute myeloid leukemia.
    Cancer Res. 2016 Nov 21. pii: canres.1095.2016.
    PubMed     Text format     Abstract available


  23. DING L, Sun QY, Tan KT, Chien W, et al
    Mutational landscape of pediatric acute lymphoblastic leukemia.
    Cancer Res. 2016 Nov 21. pii: canres.1303.2016.
    PubMed     Text format     Abstract available


  24. WEI TW, Wu PY, Wu TJ, Hou HA, et al
    Aurora A and NF-kappaB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA.
    Cancer Res. 2016 Nov 10. doi: 10.1158/0008-5472.CAN-16-1004.
    PubMed     Text format     Abstract available


    October 2016
  25. DUQUE-AFONSO J, Lin CH, Han K, Wei MC, et al
    E2A-PBX1 remodels oncogenic signaling networks in B-cell precursor acute lymphoid leukemia.
    Cancer Res. 2016 Oct 7. pii: canres.1899.2016.
    PubMed     Text format     Abstract available


  26. ZHENG X, Fan X, Fu B, Zheng M, et al
    EpCAM inhibition sensitizes chemoresistant leukemia to immune surveillance.
    Cancer Res. 2016 Oct 3. pii: canres.0842.2016.
    PubMed     Text format     Abstract available


    September 2016
  27. LI JM, Petersen CT, Li J, Panjwani R, et al
    Modulation of Immune Checkpoints and Graft-versus-Leukemia in Allogeneic Transplants by Vasoactive Intestinal Peptide.
    Cancer Res. 2016 Sep 26. pii: canres.0427.2016.
    PubMed     Text format     Abstract available


  28. TRAER E, Martinez J, Javidi-Sharifi N, Agarwal A, et al
    FGF2 from marrow microenvironment promotes resistance to FLT3 inhibitors in acute myeloid leukemia.
    Cancer Res. 2016 Sep 26. pii: canres.3569.2016.
    PubMed     Text format     Abstract available



  29. Correction: An IkappaB alpha Inhibitor Causes Leukemia Cell Death through a p38 MAP Kinase-dependent, NF-kappaB-independent Mechanism.
    Cancer Res. 2016;76:5584.
    PubMed     Text format    


  30. SAMUEL J, Jayne S, Chen Y, Majid A, et al
    Posttranscriptional upregulation of p53 by reactive oxygen species in chronic lymphocytic leukemia.
    Cancer Res. 2016 Sep 7. pii: canres.0843.2016.
    PubMed     Text format     Abstract available


    August 2016
  31. GATJEN M, Brand F, Grau M, Gerlach K, et al
    Splenic marginal zone granulocytes acquire an accentuated neutrophil B cell-helper phenotype in chronic lymphocytic leukemia.
    Cancer Res. 2016 Aug 3. pii: canres.3486.2015.
    PubMed     Text format     Abstract available


    June 2016
  32. RICHMOND J, Robbins A, Evans K, Beck D, et al
    Acute sensitivity of Ph-like acute lymphoblastic leukemia to the SMAC-mimetic birinapant.
    Cancer Res. 2016 Jun 14. pii: canres.0523.2016.
    PubMed     Text format     Abstract available


  33. BACHEGOWDA L, Morrone K, Winski SL, Mantzaris I, et al
    Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia.
    Cancer Res. 2016 Jun 10. pii: canres.3062.2015.
    PubMed     Text format     Abstract available


  34. JIANG X, Bugno J, Hu C, Yang Y, et al
    Eradication of acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles.
    Cancer Res. 2016 Jun 8. pii: canres.2949.2015.
    PubMed     Text format     Abstract available


    May 2016
  35. KOTHARI A, Hittelman WN, Chambers TC
    Cell cycle-dependent mechanisms underlie vincristine-induced death of primary acute lymphoblastic leukemia cells.
    Cancer Res. 2016 May 6. pii: canres.2104.2015.
    PubMed     Text format     Abstract available



  36. Correction: Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function.
    Cancer Res. 2016;76:2847.
    PubMed     Text format    


  37. SANDRI S, Bobisse S, Moxley K, Lamolinara A, et al
    Feasibility of Telomerase-Specific Adoptive T-cell Therapy for B-cell Chronic Lymphocytic Leukemia and Solid Malignancies.
    Cancer Res. 2016;76:2540-2551.
    PubMed     Text format     Abstract available


    March 2016
  38. YU ZY, Xiao H, Wang LM, Shen X, et al
    Natural product vibsanine A induces differentiation of myeloid leukemia cells through PKC activation.
    Cancer Res. 2016 Mar 16. pii: canres.1616.2015.
    PubMed     Text format     Abstract available


  39. FREIREICH E
    Commentary on Thomas and Epstein: "Bone Marrow Transplantation in Acute Leukemia".
    Cancer Res. 2016;76:1301-2.
    PubMed     Text format    


  40. CONERY AR, Centore RC, Spillane KL, Follmer NE, et al
    Preclinical Anticancer Efficacy of BET Bromodomain Inhibitors Is Determined by the Apoptotic Response.
    Cancer Res. 2016;76:1313-9.
    PubMed     Text format     Abstract available


  41. JOHNSON N, De Ieso P, Migliorini G, Orr N, et al
    Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.
    Cancer Res. 2016.
    PubMed     Text format     Abstract available


  42. GUPTA K, Stefan T, Ignatz-Hoover J, Moreton S, et al
    GSK-3 inhibition sensitizes acute myeloid leukemia cells to 1,25D-mediated differentiation.
    Cancer Res. 2016 Mar 10. pii: canres.2290.2015.
    PubMed     Text format     Abstract available


  43. GRIESSINGER E, Anjos-Afonso F, Vargaftig J, Taussig D, et al
    Frequency and dynamics of leukemia-initiating cells during short-term ex vivo culture informs outcomes in acute myeloid leukemia patients.
    Cancer Res. 2016 Mar 9. pii: canres.2063.2015.
    PubMed     Text format     Abstract available


  44. DOLAI S, Sia KC, Robbins AK, Zhong L, et al
    Quantitative phosphotyrosine profiling of patient-derived xenografts identifies therapeutic targets in pediatric leukemia.
    Cancer Res. 2016 Mar 9. pii: canres.2786.2015.
    PubMed     Text format     Abstract available


  45. FARRAR JE, Schuback HL, Ries RE, Wai D, et al
    Genomic profiling of pediatric acute myeloid leukemia reveals a changing mutational landscape from disease diagnosis to relapse.
    Cancer Res. 2016 Mar 3. pii: canres.1015.2015.
    PubMed     Text format     Abstract available


  46. CLARKSON BD
    Commentary on Sandberg et al., "The In Vivo Chromosome Constitution of Marrow".
    Cancer Res. 2016;76:991-3.
    PubMed     Text format    


    February 2016
  47. GUO Y, Updegraff BL, Park S, Durakoglugil D, et al
    Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis.
    Cancer Res. 2016;76:773-86.
    PubMed     Text format     Abstract available


  48. KRENN PW, Hofbauer SW, Pucher S, Hutterer E, et al
    ILK induction in lymphoid organs by a TNFalpha-NF-kappaB-regulated pathway promotes the development of chronic lymphocytic leukemia.
    Cancer Res. 2016 Feb 2. pii: canres.3379.2015.
    PubMed     Text format     Abstract available


  49. MCGRATH JP, Williamson KE, Balasubramanian S, Odate S, et al
    Pharmacological inhibition of the histone lysine demethylase KDM1A suppresses the growth of multiple acute myeloid leukemia subtypes.
    Cancer Res. 2016 Feb 2. pii: canres.2333.2015.
    PubMed     Text format     Abstract available


  50. PRIETO C, Stam RW, Agraz-Doblas A, Ballerini P, et al
    Activated KRAS cooperates with MLLAF4 to promote extramedullary engraftment and migration of cord blood CD34+ HSPC but is insufficient to initiate leukemia.
    Cancer Res. 2016 Feb 2. pii: canres.2769.2015.
    PubMed     Text format     Abstract available


  51. CHEN WC, Yuan JS, Xing Y, Mitchell A, et al
    An integrated analysis of heterogeneous drug responses in acute myeloid leukemia that enables the discovery of predictive biomarkers.
    Cancer Res. 2016 Feb 1. pii: canres.2743.2015.
    PubMed     Text format     Abstract available


  52. LI Z, Chen P, Su R, Hu C, et al
    PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease.
    Cancer Res. 2016;76:619-29.
    PubMed     Text format     Abstract available


    January 2016
  53. ZHANG W, Borthakur G, Gao C, Chen Y, et al
    The dual MEK/FLT3 inhibitor E6201 exerts cytotoxic activity against acute myeloid leukemia cells harboring resistance-conferring FLT3 mutations.
    Cancer Res. 2016 Jan 28. pii: canres.1580.2015.
    PubMed     Text format     Abstract available


  54. WANG W, Zimmerman G, Huang X, Yu S, et al
    Aberrant Notch signaling in the bone marrow microenvironment of acute lymphoid leukemia suppresses osteoblast-mediated support of hematopoietic niche function.
    Cancer Res. 2016 Jan 22. pii: canres.2092.2015.
    PubMed     Text format     Abstract available


    December 2015
  55. MAXSON JE, Abel ML, Wang J, Deng X, et al
    Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.
    Cancer Res. 2015.
    PubMed     Text format     Abstract available



  56. Correction: CD38 in Hairy Cell Leukemia Is a Marker of Poor Prognosis and a New Target for Therapy.
    Cancer Res. 2015;75:5167.
    PubMed     Text format    


  57. BAKER A, Gregory G, Verbrugge I, Kats L, et al
    The CDK9 inhibitor dinaciclib exerts potent apoptotic and antitumor effects in preclinical models of MLL-rearranged acute myeloid leukemia.
    Cancer Res. 2015 Dec 1. pii: canres.1070.2015.
    PubMed     Text format     Abstract available


    October 2015
  58. MITOBE Y, Yasunaga J, Furuta R, Matsuoka M, et al
    HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival.
    Cancer Res. 2015;75:4143-52.
    PubMed     Text format     Abstract available


  59. CAPUANO C, Romanelli M, Pighi C, Cimino G, et al
    Anti-CD20 Therapy Acts via FcgammaRIIIA to Diminish Responsiveness of Human Natural Killer Cells.
    Cancer Res. 2015;75:4097-108.
    PubMed     Text format     Abstract available


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