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Amedeo Prize 2008
The 21 Finalists


  Leukemia

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Articles published in Cancer Res

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Single Articles


    May 2008
  1. HACKANSON B , Bennett KL, Brena RM, Jiang J, et al
    Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia.
    Cancer Res. 2008;68:3142-51.
    PubMed     Related articles    Abstract available


    April 2008
  2. FELICETTI F , Errico MC, Bottero L, Segnalini P, et al
    The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms.
    Cancer Res. 2008;68:2745-54.
    PubMed     Related articles    Abstract available


  3. CAI J , Damaraju VL, Groulx N, Mowles D, et al
    Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells.
    Cancer Res. 2008;68:2349-57.
    PubMed     Related articles    Abstract available


  4. KIM SH , Ricci MS, El-Deiry WS
    Mcl-1: a gateway to TRAIL sensitization.
    Cancer Res. 2008;68:2062-4.
    PubMed     Related articles    Abstract available


    February 2008
  5. OUILLETTE P , Erba H, Kujawski L, Kaminski M, et al
    Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14.
    Cancer Res. 2008;68:1012-21.
    PubMed     Related articles    Abstract available


  6. NONOMURA C , Kikuchi J, Kiyokawa N, Ozaki H, et al
    CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1.
    Cancer Res. 2008;68:790-9.
    PubMed     Related articles    Abstract available


  7. BOTTGER S , Jerszyk E, Low B, Walker C, et al
    Genotoxic stress-induced expression of p53 and apoptosis in leukemic clam hemocytes with cytoplasmically sequestered p53.
    Cancer Res. 2008;68:777-82.
    PubMed     Related articles    Abstract available


    January 2008
  8. BREMER E , ten Cate B, Samplonius DF, Mueller N, et al
    Superior activity of fusion protein scFvRit:sFasL over cotreatment with rituximab and Fas agonists.
    Cancer Res. 2008;68:597-604.
    PubMed     Related articles    Abstract available


  9. FAZIO G , Palmi C, Rolink A, Biondi A, et al
    PAX5/TEL acts as a transcriptional repressor causing down-modulation of CD19, enhances migration to CXCL12, and confers survival advantage in pre-BI cells.
    Cancer Res. 2008;68:181-9.
    PubMed     Related articles    Abstract available


    December 2007
  10. SHU ST , Nadella MV, Dirksen WP, Fernandez SA, et al
    A novel bioluminescent mouse model and effective therapy for adult T-cell leukemia/lymphoma.
    Cancer Res. 2007;67:11859-66.
    PubMed     Related articles    Abstract available


  11. KAWANO T , Ito M, Raina D, Wu Z, et al
    MUC1 oncoprotein regulates Bcr-Abl stability and pathogenesis in chronic myelogenous leukemia cells.
    Cancer Res. 2007;67:11576-84.
    PubMed     Related articles    Abstract available


  12. GREGORY MS , Saff RR, Marshak-Rothstein A, Ksander BR, et al
    Control of ocular tumor growth and metastatic spread by soluble and membrane Fas ligand.
    Cancer Res. 2007;67:11951-8.
    PubMed     Related articles    Abstract available


  13. OMIDVAR N , Kogan S, Beurlet S, le Pogam C, et al
    BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia.
    Cancer Res. 2007;67:11657-67.
    PubMed     Related articles    Abstract available


  14. FERRAJOLI A , Faderl S, Van Q, Koch P, et al
    WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells.
    Cancer Res. 2007;67:11291-9.
    PubMed     Related articles    Abstract available


  15. KIM TK , Lee JS, Oh SY, Jin X, et al
    Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells.
    Cancer Res. 2007;67:11133-40.
    PubMed     Related articles    Abstract available


    November 2007
  16. KAWAGOE H , Kandilci A, Kranenburg TA, Grosveld GC, et al
    Overexpression of N-Myc Rapidly Causes Acute Myeloid Leukemia in Mice.
    Cancer Res. 2007;67:10677-10685.
    PubMed     Related articles    Abstract available


  17. MATSUOKA M , Watanabe T, Kannagi M, Bangham C, et al
    Meeting Report on the 13th International Conference on Human Retrovirology: Human T-Cell Leukemia Virus Research 30 Years after Adult T-Cell Leukemia.
    Cancer Res. 2007;67:10638-10641.
    PubMed     Related articles       Free Full Text


  18. DELVA L , Zelent A, Naoe T, Fenaux P, et al
    Meeting report: the 11th International Conference on Differentiation Therapy and Innovative Therapeutics in Oncology.
    Cancer Res. 2007;67:10635-7.
    PubMed     Related articles   


  19. BASTIANUTTO C , Mian A, Symes J, Mocanu J, et al
    Local Radiotherapy Induces Homing of Hematopoietic Stem Cells to the Irradiated Bone Marrow.
    Cancer Res. 2007;67:10112-10116.
    PubMed     Related articles    Abstract available


    October 2007
  20. BROWN VI , Hulitt J, Fish J, Sheen C, et al
    Thymic Stromal-Derived Lymphopoietin Induces Proliferation of Pre-B Leukemia and Antagonizes mTOR Inhibitors, Suggesting a Role for Interleukin-7R{alpha} Signaling.
    Cancer Res. 2007;67:9963-70.
    PubMed     Related articles    Abstract available


  21. FURUICHI Y , Goi K, Inukai T, Sato H, et al
    Fms-like Tyrosine Kinase 3 Ligand Stimulation Induces MLL-Rearranged Leukemia Cells into Quiescence Resistant to Antileukemic Agents.
    Cancer Res. 2007;67:9852-61.
    PubMed     Related articles    Abstract available


  22. ROSATO RR , Almenara JA, Coe S, Grant S, et al
    The Multikinase Inhibitor Sorafenib Potentiates TRAIL Lethality in Human Leukemia Cells in Association with Mcl-1 and cFLIPL Down-regulation.
    Cancer Res. 2007;67:9490-500.
    PubMed     Related articles    Abstract available


    September 2007
  23. RASSOOL FV , Gaymes TJ, Omidvar N, Brady N, et al
    Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?
    Cancer Res. 2007;67:8762-71.
    PubMed     Related articles    Abstract available


  24. DURIG J , Ebeling P, Grabellus F, Sorg UR, et al
    A Novel Nonobese Diabetic/Severe Combined Immunodeficient Xenograft Model for Chronic Lymphocytic Leukemia Reflects Important Clinical Characteristics of the Disease.
    Cancer Res. 2007;67:8653-8661.
    PubMed     Related articles    Abstract available


  25. GALLAY N , Anani L, Lopez A, Colombat P, et al
    The Role of Platelet/Endothelial Cell Adhesion Molecule 1 (CD31) and CD38 Antigens in Marrow Microenvironmental Retention of Acute Myelogenous Leukemia Cells.
    Cancer Res. 2007;67:8624-32.
    PubMed     Related articles    Abstract available


  26. FABER J , Armstrong SA
    Mixed lineage leukemia translocations and a leukemia stem cell program.
    Cancer Res. 2007;67:8425-8.
    PubMed     Related articles    Abstract available


  27. TAYLOR KH , Kramer RS, Davis JW, Guo J, et al
    Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing.
    Cancer Res. 2007;67:8511-8.
    PubMed     Related articles    Abstract available


  28. CAUDELL D , Zhang Z, Chung YJ, Aplan PD, et al
    Expression of a CALM-AF10 Fusion Gene Leads to Hoxa Cluster Overexpression and Acute Leukemia in Transgenic Mice.
    Cancer Res. 2007;67:8022-31.
    PubMed     Related articles    Abstract available


    August 2007
  29. WANG R , Li C, Song D, Zhao G, et al
    Ethacrynic Acid Butyl-Ester Induces Apoptosis in Leukemia Cells through a Hydrogen Peroxide Mediated Pathway Independent of Glutathione S-Transferase P1-1 Inhibition.
    Cancer Res. 2007;67:7856-64.
    PubMed     Related articles    Abstract available


  30. CASLINI C , Yang Z, El-Osta M, Milne TA, et al
    Interaction of MLL amino terminal sequences with menin is required for transformation.
    Cancer Res. 2007;67:7275-83.
    PubMed     Related articles    Abstract available


  31. PARIKH C , Subrahmanyam R, Ren R
    Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice.
    Cancer Res. 2007;67:7139-46.
    PubMed     Related articles    Abstract available


    July 2007
  32. FASCHING CL , Neumann AA, Muntoni A, Yeager TR, et al
    DNA Damage Induces Alternative Lengthening of Telomeres (ALT) Associated Promyelocytic Leukemia Bodies that Preferentially Associate with Linear Telomeric DNA.
    Cancer Res. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  33. CHU S , Li L, Singh H, Bhatia R, et al
    BCR-Tyrosine 177 Plays an Essential Role in Ras and Akt Activation and in Human Hematopoietic Progenitor Transformation in Chronic Myelogenous Leukemia.
    Cancer Res. 2007;67:7045-53.
    PubMed     Related articles    Abstract available


  34. ANDING AL , Chapman JS, Barnett DW, Curley RW Jr, et al
    The unhydrolyzable fenretinide analogue 4-hydroxybenzylretinone induces the proapoptotic genes GADD153 (CHOP) and Bcl-2-binding component 3 (PUMA) and apoptosis that is caspase- dependent and independent of the retinoic acid receptor.
    Cancer Res. 2007;67:6270-7.
    PubMed     Related articles    Abstract available


  35. BOLLI N , Nicoletti I, De Marco MF, Bigerna B, et al
    Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants.
    Cancer Res. 2007;67:6230-7.
    PubMed     Related articles    Abstract available


    June 2007
  36. FERNBERG P , Odenbro A, Bellocco R, Boffetta P, et al
    Tobacco use, body mass index, and the risk of leukemia and multiple myeloma: a nationwide cohort study in sweden.
    Cancer Res. 2007;67:5983-6.
    PubMed     Related articles    Abstract available


  37. LANDAIS S , Landry S, Legault P, Rassart E, et al
    Oncogenic Potential of the miR-106-363 Cluster and Its Implication in Human T-Cell Leukemia.
    Cancer Res. 2007;67:5699-707.
    PubMed     Related articles    Abstract available


  38. MALYUKOVA A , Dohda T, von der Lehr N, Akhondi S, et al
    The Tumor Suppressor Gene hCDC4 Is Frequently Mutated in Human T-Cell Acute Lymphoblastic Leukemia with Functional Consequences for Notch Signaling.
    Cancer Res. 2007;67:5611-6.
    PubMed     Related articles    Abstract available


  39. SENYUK V , Sinha KK, Li D, Rinaldi CR, et al
    Repression of RUNX1 activity by EVI1: a new role of EVI1 in leukemogenesis.
    Cancer Res. 2007;67:5658-66.
    PubMed     Related articles    Abstract available


  40. BRAUER KM , Werth D, von Schwarzenberg K, Bringmann A, et al
    BCR-ABL Activity Is Critical for the Immunogenicity of Chronic Myelogenous Leukemia Cells.
    Cancer Res. 2007;67:5489-97.
    PubMed     Related articles    Abstract available


  41. DE MILITO A , Iessi E, Logozzi M, Lozupone F, et al
    Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species.
    Cancer Res. 2007;67:5408-17.
    PubMed     Related articles    Abstract available


  42. VOLPE G , Cignetti A, Panuzzo C, Kuka M, et al
    Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches.
    Cancer Res. 2007;67:5300-7.
    PubMed     Related articles    Abstract available


  43. SLAPE C , Hartung H, Lin YW, Bies J, et al
    Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation.
    Cancer Res. 2007;67:5148-55.
    PubMed     Related articles    Abstract available


    May 2007
  44. DING Q , He X, Xia W, Hsu JM, et al
    Myeloid Cell Leukemia-1 Inversely Correlates with Glycogen Synthase Kinase-3{beta} Activity and Associates with Poor Prognosis in Human Breast Cancer.
    Cancer Res. 2007;67:4564-71.
    PubMed     Related articles    Abstract available   Free Full Text


  45. LI L , Han W, Gu Y, Qiu S, et al
    Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore.
    Cancer Res. 2007;67:4894-903.
    PubMed     Related articles    Abstract available


  46. SASSANO A , Katsoulidis E, Antico G, Altman JK, et al
    Suppressive effects of statins on acute promyelocytic leukemia cells.
    Cancer Res. 2007;67:4524-32.
    PubMed     Related articles    Abstract available


  47. BACHMANN PS , Gorman R, Papa RA, Bardell JE, et al
    Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia.
    Cancer Res. 2007;67:4482-90.
    PubMed     Related articles    Abstract available


  48. SAUDEMONT A , Hamrouni A, Marchetti P, Liu J, et al
    Dormant tumor cells develop cross-resistance to apoptosis induced by CTLs or imatinib mesylate via methylation of suppressor of cytokine signaling 1.
    Cancer Res. 2007;67:4491-8.
    PubMed     Related articles    Abstract available


    April 2007
  49. SANCHEZ-MARTIN CC , Davalos A, Martin-Sanchez C, de la Pena G, et al
    Cholesterol Starvation Induces Differentiation of Human Leukemia HL-60 Cells.
    Cancer Res. 2007;67:3379-86.
    PubMed     Related articles    Abstract available


  50. KOJIMA K , Konopleva M, Samudio IJ, Ruvolo V, et al
    Mitogen-Activated Protein Kinase Kinase Inhibition Enhances Nuclear Proapoptotic Function of p53 in Acute Myelogenous Leukemia Cells.
    Cancer Res. 2007;67:3210-9.
    PubMed     Related articles    Abstract available


    March 2007
  51. TAYLOR KH , Pena-Hernandez KE, Davis JW, Arthur GL, et al
    Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia.
    Cancer Res. 2007;67:2617-25.
    PubMed     Related articles    Abstract available


  52. SINGH H , Serrano LM, Pfeiffer T, Olivares S, et al
    Combining adoptive cellular and immunocytokine therapies to improve treatment of B-lineage malignancy.
    Cancer Res. 2007;67:2872-80.
    PubMed     Related articles    Abstract available


  53. WYSOCZYNSKI M , Miekus K, Jankowski K, Wanzeck J, et al
    Leukemia inhibitory factor: a newly identified metastatic factor in rhabdomyosarcomas.
    Cancer Res. 2007;67:2131-40.
    PubMed     Related articles    Abstract available


  54. FRIESEN C , Glatting G, Koop B, Schwarz K, et al
    Breaking Chemoresistance and Radioresistance with [213Bi]anti-CD45 Antibodies in Leukemia Cells.
    Cancer Res. 2007;67:1950-8.
    PubMed     Related articles    Abstract available


  55. WICHMANN C , Chen L, Heinrich M, Baus D, et al
    Targeting the oligomerization domain of ETO interferes with RUNX1/ETO oncogenic activity in t(8;21)-positive leukemic cells.
    Cancer Res. 2007;67:2280-9.
    PubMed     Related articles    Abstract available


    February 2007
  56. NAGEL S , Scherr M, Kel A, Hornischer K, et al
    Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-Cell Acute Lymphoblastic Leukemia by Remote 3'-BCL11B Enhancers and Coregulation by PU.1 and HMGA1.
    Cancer Res. 2007;67:1461-71.
    PubMed     Related articles    Abstract available


  57. SHI Y , White D, He L, Miller RL, et al
    Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agents.
    Cancer Res. 2007;67:1823-31.
    PubMed     Related articles    Abstract available


  58. PODAR K , Raab MS, Tonon G, Sattler M, et al
    Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma.
    Cancer Res. 2007;67:1680-8.
    PubMed     Related articles    Abstract available


  59. AGRAWAL S , Unterberg M, Koschmieder S, Zur Stadt U, et al
    DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia.
    Cancer Res. 2007;67:1370-7.
    PubMed     Related articles    Abstract available


  60. HOLTZ M , Forman SJ, Bhatia R
    Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment.
    Cancer Res. 2007;67:1113-20.
    PubMed     Related articles    Abstract available


  61. CHIN KT , Chun AC, Ching YP, Jeang KT, et al
    Human T-Cell Leukemia Virus Oncoprotein Tax Represses Nuclear Receptor-Dependent Transcription by Targeting Coactivator TAX1BP1.
    Cancer Res. 2007;67:1072-81.
    PubMed     Related articles    Abstract available


  62. MARKUS J , Garin MT, Bies J, Galili N, et al
    Methylation-Independent Silencing of the Tumor Suppressor INK4b (p15) by CBF{beta}-SMMHC in Acute Myelogenous Leukemia with inv(16).
    Cancer Res. 2007;67:992-1000.
    PubMed     Related articles    Abstract available


  63. CHEN A , Liu S, Park D, Kang Y, et al
    Depleting intratumoral CD4+CD25+ regulatory T cells via FasL protein transfer enhances the therapeutic efficacy of adoptive T cell transfer.
    Cancer Res. 2007;67:1291-8.
    PubMed     Related articles    Abstract available


    January 2007
  64. CAMMENGA J , Niebuhr B, Horn S, Bergholz U, et al
    RUNX1 DNA-binding mutants, associated with minimally differentiated acute myelogenous leukemia, disrupt myeloid differentiation.
    Cancer Res. 2007;67:537-45.
    PubMed     Related articles    Abstract available


  65. CHEN S , Dai Y, Harada H, Dent P, et al
    Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.
    Cancer Res. 2007;67:782-91.
    PubMed     Related articles    Abstract available


  66. TABE Y , Jin L, Tsutsumi-Ishii Y, Xu Y, et al
    Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.
    Cancer Res. 2007;67:684-94.
    PubMed     Related articles    Abstract available


  67. ZINN RL , Pruitt K, Eguchi S, Baylin SB, et al
    hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site.
    Cancer Res. 2007;67:194-201.
    PubMed     Related articles    Abstract available


    December 2006
  68. PEKARSKY Y , Santanam U, Cimmino A, Palamarchuk A, et al
    Tcl1 Expression in Chronic Lymphocytic Leukemia Is Regulated by miR-29 and miR-181.
    Cancer Res. 2006;66:11590-3.
    PubMed     Related articles    Abstract available


  69. CHEN D , Chan R, Waxman S, Jing Y, et al
    Buthionine Sulfoximine Enhancement of Arsenic Trioxide-Induced Apoptosis in Leukemia and Lymphoma Cells Is Mediated via Activation of c-Jun NH2-Terminal Kinase and Up-regulation of Death Receptors.
    Cancer Res. 2006;66:11416-23.
    PubMed     Related articles    Abstract available


  70. HEILMAN SA , Kuo YH, Goudswaard CS, Valk PJ, et al
    Cbf{beta} Reduces Cbf{beta}-SMMHC-Associated Acute Myeloid Leukemia in Mice.
    Cancer Res. 2006;66:11214-8.
    PubMed     Related articles    Abstract available


  71. FUJITA K , Tsujimura A, Miyagawa Y, Kiuchi H, et al
    Isolation of Germ Cells from Leukemia and Lymphoma Cells in a Human In vitro Model: Potential Clinical Application for Restoring Human Fertility after Anticancer Therapy.
    Cancer Res. 2006;66:11166-71.
    PubMed     Related articles    Abstract available


  72. SHACKELFORD D , Kenific C, Blusztajn A, Waxman S, et al
    Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide.
    Cancer Res. 2006;66:11360-9.
    PubMed     Related articles    Abstract available


    November 2006
  73. KALINKOVICH A , Tavor S, Avigdor A, Kahn J, et al
    Functional CXCR4-Expressing Microparticles and SDF-1 Correlate with Circulating Acute Myelogenous Leukemia Cells.
    Cancer Res. 2006;66:11013-11020.
    PubMed     Related articles    Abstract available


  74. CHEN R , Gandhi V, Plunkett W
    A Sequential Blockade Strategy for the Design of Combination Therapies to Overcome Oncogene Addiction in Chronic Myelogenous Leukemia.
    Cancer Res. 2006;66:10959-10966.
    PubMed     Related articles    Abstract available


  75. SELLERI C , Montuori N, Ricci P, Visconte V, et al
    In vivo activity of the cleaved form of soluble urokinase receptor: a new hematopoietic stem/progenitor cell mobilizer.
    Cancer Res. 2006;66:10885-90.
    PubMed     Related articles    Abstract available


    October 2006
  76. SANTILLAN DA , Theisler CM, Ryan AS, Popovic R, et al
    Bromodomain and Histone Acetyltransferase Domain Specificities Control Mixed Lineage Leukemia Phenotype.
    Cancer Res. 2006;66:10032-10039.
    PubMed     Related articles    Abstract available


  77. KOMETANI K , Aoki M, Kawamata S, Shinozuka Y, et al
    Role of SPA-1 in Phenotypes of Chronic Myelogenous Leukemia Induced by BCR-ABL-Expressing Hematopoietic Progenitors in a Mouse Model.
    Cancer Res. 2006;66:9967-76.
    PubMed     Related articles    Abstract available


  78. NG AP , Howe Fong J, Sijin Nin D, Hirpara JL, et al
    Cleavage of misfolded nuclear receptor corepressor confers resistance to unfolded protein response-induced apoptosis.
    Cancer Res. 2006;66:9903-12.
    PubMed     Related articles    Abstract available


  79. CADIEUX C , Fournier S, Peterson AC, Bedard C, et al
    Transgenic Mice Expressing the p75 CCAAT-Displacement Protein/Cut Homeobox Isoform Develop a Myeloproliferative Disease-Like Myeloid Leukemia.
    Cancer Res. 2006;66:9492-501.
    PubMed     Related articles    Abstract available   Free Full Text


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