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  Malignant Melanoma

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Articles published in Clin Cancer Res

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    October 2017
  1. KOSTER BD, van den Hout MFCM, Sluijter BJR, Molenkamp BG, et al
    Local Adjuvant Treatment with Low-Dose CpG-B Offers Durable Protection against Disease Recurrence in Clinical Stage I-II Melanoma: Data from Two Randomized Phase II Trials.
    Clin Cancer Res. 2017;23:5679-5686.
    PubMed     Text format     Abstract available


    September 2017
  2. BARTOLOME RA, Aizpurua C, Jaen M, Torres S, et al
    Monoclonal antibodies directed against cadherin RGD exhibit therapeutic activity against melanoma and colorectal cancer metastasis.
    Clin Cancer Res. 2017 Sep 15. pii: clincanres.1444.2017.
    PubMed     Text format     Abstract available


    August 2017
  3. ENNEN M, Keime C, Gambi G, Kieny A, et al
    MITF-high and MITF-low cells and a novel subpopulation expressing genes of both cell states contribute to intra and inter-tumoral heterogeneity of primary melanoma.
    Clin Cancer Res. 2017 Aug 28. pii: clincanres.0010.2017.
    PubMed     Text format     Abstract available


  4. KONG Y, Sheng X, Wu X, Yan J, et al
    Frequent Genetic Aberrations in the CDK4 Pathway in Acral Melanoma indicate the potential for CDK4/6 Inhibitors in Targeted Therapy.
    Clin Cancer Res. 2017 Aug 22. pii: clincanres.0070.2017.
    PubMed     Text format     Abstract available


  5. KASHANI-SABET M, Nosrati M, Miller J, Sagebiel R, et al
    Prospective Validation of Molecular Prognostic Markers in Cutaneous Melanoma: A Correlative Analysis of E1690.
    Clin Cancer Res. 2017 Aug 8. pii: clincanres.1317.2017.
    PubMed     Text format     Abstract available


    July 2017
  6. NIESSNER H, Sinnberg T, Kosnopfel C, Smalley KSM, et al
    BRAF inhibitors amplify the pro-apoptotic activity of MEK inhibitors by inducing ER stress in NRAS-mutant melanoma.
    Clin Cancer Res. 2017 Jul 19. pii: clincanres.0098.2017.
    PubMed     Text format     Abstract available


  7. KAKAVAND H, Rawson RV, Pupo GM, Yang JYH, et al
    PD-L1 expression and immune escape in melanoma resistanceto MAPK inhibitors.
    Clin Cancer Res. 2017 Jul 19. pii: clincanres.1688.2016.
    PubMed     Text format     Abstract available


  8. BAI X, Kong Y, Chi Z, Sheng X, et al
    MAPK pathway and TERT promoter gene mutation pattern and its prognostic value in melanoma patients a retrospective study of 2793 cases.
    Clin Cancer Res. 2017 Jul 18. pii: clincanres.0980.2017.
    PubMed     Text format     Abstract available


    June 2017
  9. DELORD JP, Robert C, Nyakas M, McArthur GA, et al
    Phase I Dose-Escalation and -Expansion Study of the BRAF Inhibitor Encorafenib (LGX818) in Metastatic BRAF-Mutant Melanoma.
    Clin Cancer Res. 2017 Jun 13. pii: clincanres.2923.2016.
    PubMed     Text format     Abstract available


  10. NISHINO M, Giobbie-Hurder A, Manos MP, Bailey N, et al
    Immune-Related Tumor Response Dynamics in Melanoma Patients Treated with Pembrolizumab: Identifying Markers for Clinical Outcome and Treatment Decisions.
    Clin Cancer Res. 2017 Jun 7. doi: 10.1158/1078-0432.CCR-17-0114.
    PubMed     Text format     Abstract available


    May 2017
  11. KULKARNI A, Al-Hraishawi H, Simhadri S, Hirshfield KM, et al
    BRAF fusion as a novel mechanism of acquired resistance to vemurafenib in BRAF V600E mutant melanoma.
    Clin Cancer Res. 2017 May 24. pii: clincanres.0758.2016.
    PubMed     Text format     Abstract available


  12. BUTTERFIELD LH, Zhao F, Lee S, Tarhini AA, et al
    Immune correlates of GM-CSF and melanoma peptide vaccination in a randomized trial for the adjuvant therapy of resected high-risk melanoma (E4697).
    Clin Cancer Res. 2017 May 23. pii: clincanres.3016.2016.
    PubMed     Text format     Abstract available


  13. WONGCHENKO MJ, McArthur GA, Dreno B, Larkin J, et al
    Gene Expression Profiling in BRAF-Mutated Melanoma Reveals Patient Subgroups With Poor Outcomes to Vemurafenib That May Be Overcome by Cobimetinib Plus Vemurafenib.
    Clin Cancer Res. 2017 May 23. pii: clincanres.0172.2017.
    PubMed     Text format     Abstract available


  14. VILAIN RE, Menzies AM, Wilmott JS, Kakavand H, et al
    Dynamic changes in PD-L1 expression and immune infiltrates early during treatment predict response to PD-1 blockade in melanoma.
    Clin Cancer Res. 2017 May 16. pii: clincanres.0698.2016.
    PubMed     Text format     Abstract available


    April 2017
  15. FRIEDMAN AA, Xia Y, Trippa L, Le LP, et al
    Feasibility of ultra-high-throughput functional screening of melanoma biopsies for discovery of novel cancer drug combinations.
    Clin Cancer Res. 2017 Apr 26. pii: clincanres.3029.2016.
    PubMed     Text format     Abstract available


  16. SUNSHINE JC, Nguyen P, Kaunitz G, Cottrell T, et al
    PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison.
    Clin Cancer Res. 2017 Apr 20. pii: clincanres.1821.2016.
    PubMed     Text format     Abstract available


  17. SEGAL NH, Logan TF, Hodi FS, McDermott D, et al
    Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody.
    Clin Cancer Res. 2017;23:1929-1936.
    PubMed     Text format     Abstract available


  18. IIDA Y, Ciechanover A, Marzese DM, Hata K, et al
    Epigenetic Regulation of KPC1 Ubiquitin Ligase Effects the NF-kappaB Pathway in Melanoma.
    Clin Cancer Res. 2017 Apr 7. pii: clincanres.0146.2017.
    PubMed     Text format     Abstract available


    March 2017

  19. Correction: PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo.
    Clin Cancer Res. 2017;23:1361.
    PubMed     Text format    


    February 2017
  20. CHUK MK, Chang JT, Theoret MR, Sampene E, et al
    FDA Approval Summary: Accelerated Approval of Pembrolizumab for Second-Line Treatment of Metastatic Melanoma.
    Clin Cancer Res. 2017 Feb 24. pii: clincanres.0663.2016.
    PubMed     Text format     Abstract available


  21. BEHERA R, Kaur A, Webster MR, Kim S, et al
    Inhibition of age-related therapy resistance in melanoma by rosiglitazone-mediated induction of Klotho.
    Clin Cancer Res. 2017 Feb 23. pii: clincanres.0201.2017.
    PubMed     Text format     Abstract available


  22. EXLEY MA, Friedlander P, Alatrakchi N, Vriend L, et al
    Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: a Phase 1 Clinical Trial.
    Clin Cancer Res. 2017 Feb 13. pii: clincanres.0600.2016.
    PubMed     Text format     Abstract available


  23. BARONE A, Hazarika M, Theoret MR, Mishra-Kalyani P, et al
    FDA Approval Summary: Pembrolizumab for the Treatment of Patients with Unresectable or Metastatic Melanoma.
    Clin Cancer Res. 2017 Feb 8. pii: clincanres.0664.2016.
    PubMed     Text format     Abstract available


    January 2017
  24. DENIGER DC, Kwong ML, Pasetto A, Dudley ME, et al
    A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma.
    Clin Cancer Res. 2017;23:351-362.
    PubMed     Text format     Abstract available


  25. HAZARIKA M, Chuk MK, Theoret MR, Mushti S, et al
    U.S. FDA Approval Summary: Nivolumab for Treatment of Unresectable or Metastatic Melanoma Following Progression on Ipilimumab.
    Clin Cancer Res. 2017 Jan 13. pii: clincanres.0712.2016.
    PubMed     Text format     Abstract available


  26. BEAVER JA, Theoret MR, Mushti S, He K, et al
    FDA Approval of Nivolumab for the First-Line Treatment of Patients with BRAFV600 Wild-Type Unresectable or Metastatic Melanoma.
    Clin Cancer Res. 2017 Jan 10. pii: clincanres.0714.2016.
    PubMed     Text format     Abstract available


    November 2016
  27. GANNON P, Baumgaertner P, Huber A, Iancu EM, et al
    Rapid and continued T cell differentiation into long-term effector and memory stem cells in vaccinated melanoma patients.
    Clin Cancer Res. 2016 Nov 21. pii: clincanres.1708.2016.
    PubMed     Text format     Abstract available


  28. NAGARAJAN P, Curry JL, Ning J, Piao J, et al
    Tumor thickness and mitotic rate robustly predict melanoma-specific survival in patients with primary vulvar melanoma: A retrospective review of 100 cases.
    Clin Cancer Res. 2016 Nov 18. pii: clincanres.2126.2016.
    PubMed     Text format     Abstract available


  29. SANGIOLO D, Gammaitoni L, Giraudo L, Macagno M, et al
    Cytokine Induced Killer cells kill chemo-surviving melanoma cancer stem cells.
    Clin Cancer Res. 2016 Nov 4. pii: clincanres.1524.2016.
    PubMed     Text format     Abstract available


  30. KHALIL DN, Postow MA, Ibrahim N, Ludwig DL, et al
    An Open-Label, Dose-Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma.
    Clin Cancer Res. 2016;22:5204-5210.
    PubMed     Text format     Abstract available


    August 2016
  31. ROSE AA, Annis MG, Frederick DT, Biondini M, et al
    MAPK Pathway Inhibitors Sensitize BRAF Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB.
    Clin Cancer Res. 2016 Aug 11. pii: clincanres.1192.2016.
    PubMed     Text format     Abstract available


  32. XI L, Pham T, Payabyab EC, Sherry RM, et al
    Circulating Tumor DNA as an Early Indicator of Response to T-Cell Transfer Immunotherapy in Metastatic Melanoma.
    Clin Cancer Res. 2016 Aug 1. pii: clincanres.0613.2016.
    PubMed     Text format     Abstract available


    June 2016
  33. CARLINO MS, Long GV
    Ipilimumab Combined with Nivolumab: A Standard of Care for the Treatment of Advanced Melanoma?
    Clin Cancer Res. 2016 Jun 23. pii: clincanres.2944.2016.
    PubMed     Text format     Abstract available


  34. NIESSNER H, Schmitz J, Tabatabai G, Schmid A, et al
    PI3K pathway inhibition achieves potent antitumor activity in melanoma brain metastases in vitro and in vivo.
    Clin Cancer Res. 2016 Jun 15. pii: clincanres.0064.2016.
    PubMed     Text format     Abstract available


    May 2016
  35. WEIDE B, Martens A, Hassel JC, Berking C, et al
    Baseline biomarkers for outcome of melanoma patients treated with pembrolizumab.
    Clin Cancer Res. 2016 May 16. pii: clincanres.0127.2016.
    PubMed     Text format     Abstract available


  36. SADE-FELDMAN M, Kanterman J, Klieger Y, Ish-Shalom E, et al
    Clinical significance of circulating CD33+CD11b+HLA-DR- myeloid cells in Stage-IV melanoma patients treated with ipilimumab.
    Clin Cancer Res. 2016 May 13. pii: clincanres.3104.2015.
    PubMed     Text format     Abstract available


  37. MARTENS A, Wistuba-Hamprecht K, Yuan J, Postow MA, et al
    Increases in absolute lymphocytes and circulating CD4+ and CD8+ T cells are associated with positive clinical outcome of melanoma patients treated with ipilimumab.
    Clin Cancer Res. 2016 May 11. pii: clincanres.0249.2016.
    PubMed     Text format     Abstract available


  38. OTT PA, Hodi FS
    Talimogene Laherparepvec for the Treatment of Advanced Melanoma.
    Clin Cancer Res. 2016 May 4. pii: clincanres.2709.2016.
    PubMed     Text format     Abstract available


    April 2016
  39. KREPLER C, Xiao M, Sproesser K, Brafford PA, et al
    Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies.
    Clin Cancer Res. 2016;22:1592-602.
    PubMed     Text format     Abstract available


    March 2016
  40. ANDERSEN R, Donia M, Ellebaek E, Borch TH, et al
    Long-lasting complete responses in patients with metastatic melanoma after adoptive cell therapy with tumor-infiltrating lymphocytes and an attenuated IL-2 regimen.
    Clin Cancer Res. 2016 Mar 22. pii: clincanres.1879.2015.
    PubMed     Text format     Abstract available


  41. MADORE J, Strbenac D, Vilain R, Menzies AM, et al
    PD-L1 negative status is associated with lower mutation burden, differential expression of immune-related genes, and worse survival in stage-III melanoma.
    Clin Cancer Res. 2016 Mar 9. pii: clincanres.1714.2015.
    PubMed     Text format     Abstract available


  42. FIELD MG, Decatur CL, Kurtenbach S, Gezgin G, et al
    PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma.
    Clin Cancer Res. 2016;22:1234-42.
    PubMed     Text format     Abstract available


  43. KOHLHAPP FJ, Kaufman HL
    Molecular Pathways: Mechanism of Action for Talimogene Laherparepvec, a New Oncolytic Virus Immunotherapy.
    Clin Cancer Res. 2016;22:1048-54.
    PubMed     Text format     Abstract available


    February 2016
  44. HARTSOUGH EJ, Aplin AE
    Of Mice and Melanoma: PDX System for Modeling Personalized Medicine.
    Clin Cancer Res. 2016 Feb 3. pii: clincanres.3054.2016.
    PubMed     Text format     Abstract available


  45. CHARYCH DH, Hoch U, Langowski JL, Lee SR, et al
    NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models.
    Clin Cancer Res. 2016;22:680-90.
    PubMed     Text format     Abstract available


    January 2016
  46. MARTENS A, Wistuba-Hamprecht K, Geukes Foppen MH, Yuan J, et al
    Baseline peripheral blood biomarkers associated with clinical outcome of advanced melanoma patients treated with ipilimumab.
    Clin Cancer Res. 2016 Jan 19. pii: clincanres.2412.2015.
    PubMed     Text format     Abstract available


  47. EKMEKCIOGLU S, Davies MA, Tanese K, Roszik J, et al
    Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and its Expression Associates with Favorable Survival for Stage III Melanoma.
    Clin Cancer Res. 2016 Jan 18. pii: clincanres.2226.2015.
    PubMed     Text format     Abstract available


  48. VOGELSANG M, Martinez CN, Rendleman J, Bapodra AB, et al
    The expression quantitative trait loci in immune pathways and their effect on cutaneous melanoma prognosis.
    Clin Cancer Res. 2016 Jan 5. pii: clincanres.2066.2015.
    PubMed     Text format     Abstract available


    December 2015
  49. ROTHERMEL LD, Sabesan A, Stephens DJ, Chandran SS, et al
    Identification of an immunogenic subset of metastatic uveal melanoma.
    Clin Cancer Res. 2015 Dec 28. pii: clincanres.2294.2015.
    PubMed     Text format     Abstract available


  50. SCHREIBELT G, Bol KF, Westdorp H, Wimmers F, et al
    Effective clinical responses in metastatic melanoma patients after vaccination with primary myeloid dendritic cells.
    Clin Cancer Res. 2015 Dec 28. pii: clincanres.2205.2015.
    PubMed     Text format     Abstract available


  51. DAVAR D, Kirkwood JM
    CCR 20th Anniversary Commentary: MAPK/ERK Pathway Inhibition in Melanoma-Kinase Inhibition Redux.
    Clin Cancer Res. 2015;21:5412-5414.
    PubMed     Text format     Abstract available


  52. PIRES SILVA I, Salhi A, Giles KM, Vogelsang M, et al
    Identification of a novel pathogenic germline KDR variant in melanoma.
    Clin Cancer Res. 2015 Dec 2. pii: clincanres.1811.2015.
    PubMed     Text format     Abstract available


    November 2015
  53. HOOS A, Wolchok JD, Humphrey RW, Hodi FS, et al
    CCR 20th Anniversary Commentary: Immune-Related Response Criteria--Capturing Clinical Activity in Immuno-Oncology.
    Clin Cancer Res. 2015;21:4989-91.
    PubMed     Text format     Abstract available


    October 2015
  54. LEGAT A, Maby-El Hajjami H, Baumgaertner P, Cagnon L, et al
    Vaccination with LAG-3Ig (IMP321) and peptides induces specific CD4 and CD8 T-cell responses in metastatic melanoma patients - report of a phase I/IIa clinical trial.
    Clin Cancer Res. 2015 Oct 23. pii: clincanres.1212.2015.
    PubMed     Text format     Abstract available


  55. ZABOR EC, Heller G, Schwartz LH, Chapman PB, et al
    Correlating surrogate endpoints with overall survival at the individual patient level in BRAFV600E-mutated metastatic melanoma patients treated with vemurafenib.
    Clin Cancer Res. 2015 Oct 21. pii: clincanres.1441.2015.
    PubMed     Text format     Abstract available


  56. KONG Y, Si L, Li Y, Wu X, et al
    Analysis of mTOR Gene Aberrations in Melanoma Patients and Evaluation of Their Sensitivity to PI3K-AKT-mTOR Pathway Inhibitors.
    Clin Cancer Res. 2015 Oct 21. pii: clincanres.1110.2015.
    PubMed     Text format     Abstract available


  57. JACKSON CM, Kochel CM, Nirschl CJ, Durham NM, et al
    Systemic Tolerance Mediated by Melanoma Brain Tumors is Reversible by Radiotherapy and Vaccination.
    Clin Cancer Res. 2015 Oct 21. pii: clincanres.1516.2015.
    PubMed     Text format     Abstract available


  58. FREEMAN-KELLER M, Kim Y, Cronin H, Richards A, et al
    Nivolumab in Resected and Unresectable Metastatic Melanoma: Characteristics of Immune-Related Adverse Events and Association with Outcomes.
    Clin Cancer Res. 2015 Oct 7. pii: clincanres.1136.2015.
    PubMed     Text format     Abstract available


  59. GRANGE JM, Krone B
    Ancient Retrovirus Targeted by Engineered T Cells in Melanoma-Letter.
    Clin Cancer Res. 2015;21:4494.
    PubMed     Text format    


    August 2015
  60. WILSON MA, Zhao F, Khare S, D'Andrea K, et al
    Copy number changes are associated with response to treatment with carboplatin, paclitaxel, and sorafenib in melanoma.
    Clin Cancer Res. 2015 Aug 25. pii: clincanres.1162.2015.
    PubMed     Text format     Abstract available


  61. GEBHARDT C, Sevko A, Jiang H, Lichtenberger R, et al
    Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab.
    Clin Cancer Res. 2015 Aug 19. pii: clincanres.0676.2015.
    PubMed     Text format     Abstract available


    July 2015
  62. ANDREWS MC, Turner N, Boyd J, Roberts AW, et al
    Cellular mechanisms underlying complete hematological response of chronic myeloid leukemia to BRAF/MEK inhibition in a patient with concomitant metastatic melanoma.
    Clin Cancer Res. 2015 Jul 22. pii: clincanres.0393.2015.
    PubMed     Text format     Abstract available


  63. HONG D, Kurzrock R, Wheler JJ, Naing A, et al
    Phase I dose-escalation study of the multikinase inhibitor lenvatinib in patients with advanced solid tumors and in an expanded cohort of patients with melanoma.
    Clin Cancer Res. 2015 Jul 13. pii: clincanres.3063.2015.
    PubMed     Text format     Abstract available


  64. LIU Y, Hawkins OE, Vilgelm AE, Pawlikowski JS, et al
    Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models.
    Clin Cancer Res. 2015 Jul 7. pii: clincanres.0293.2015.
    PubMed     Text format     Abstract available


    June 2015
  65. HANNIFORD D, Zhong J, Koetz L, Gaziel-Sovran A, et al
    A miRNA-based signature detected in primary melanoma tissue predicts development of brain metastasis.
    Clin Cancer Res. 2015 Jun 18. pii: clincanres.2566.2014.
    PubMed     Text format     Abstract available


  66. SULLIVAN RJ, Flaherty KT
    New strategies in melanoma: entering the era of combinatorial therapy.
    Clin Cancer Res. 2015;21:2424-35.
    PubMed     Text format     Abstract available


  67. BOWERS JS, Nelson MH, Kundimi S, Bailey SR, et al
    Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling.
    Clin Cancer Res. 2015;21:2546-57.
    PubMed     Text format     Abstract available


    May 2015
  68. REED CM, Cresce ND, Mauldin IS, Slingluff CL Jr, et al
    Vaccination with Melanoma Helper Peptides Induces Antibody Responses Associated with Improved Overall Survival.
    Clin Cancer Res. 2015 May 12. pii: clincanres.0233.2015.
    PubMed     Text format     Abstract available


    March 2015
  69. RODRIGUEZ-GARCIA A, Gimenez-Alejandre M, Rojas JJ, Moreno R, et al
    Safety and efficacy of VCN-01, an oncolytic adenovirus combining fiber HSG-binding domain replacement with RGD and hyaluronidase expression.
    Clin Cancer Res. 2015;21:1406-18.
    PubMed     Text format     Abstract available


  70. ROBBINS PF, Kassim SH, Tran TL, Crystal JS, et al
    A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response.
    Clin Cancer Res. 2015;21:1019-27.
    PubMed     Text format     Abstract available


    February 2015
  71. MIN L, Hodi FS, Giobbie-Hurder A, Ott PA, et al
    Systemic high-dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: a retrospective cohort study.
    Clin Cancer Res. 2015;21:749-55.
    PubMed     Text format     Abstract available


  72. CHACON JA, Sarnaik AA, Chen JQ, Creasy C, et al
    Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy.
    Clin Cancer Res. 2015;21:611-21.
    PubMed     Text format     Abstract available


    January 2015
  73. LASSEN UN, Meulendijks D, Siu LL, Karanikas V, et al
    A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers.
    Clin Cancer Res. 2015;21:258-66.
    PubMed     Text format     Abstract available


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