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  Malignant Melanoma

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Articles published in Clin Cancer Res

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    April 2017
  1. SUNSHINE JC, Nguyen P, Kaunitz G, Cottrell T, et al
    PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison.
    Clin Cancer Res. 2017 Apr 20. pii: clincanres.1821.2016.
    PubMed     Text format     Abstract available


  2. IIDA Y, Ciechanover A, Marzese DM, Hata K, et al
    Epigenetic Regulation of KPC1 Ubiquitin Ligase Effects the NF-kappaB Pathway in Melanoma.
    Clin Cancer Res. 2017 Apr 7. pii: clincanres.0146.2017.
    PubMed     Text format     Abstract available


    March 2017

  3. Correction: PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo.
    Clin Cancer Res. 2017;23:1361.
    PubMed     Text format    


    February 2017
  4. CHUK MK, Chang JT, Theoret MR, Sampene E, et al
    FDA Approval Summary: Accelerated Approval of Pembrolizumab for Second-Line Treatment of Metastatic Melanoma.
    Clin Cancer Res. 2017 Feb 24. pii: clincanres.0663.2016.
    PubMed     Text format     Abstract available


  5. BEHERA R, Kaur A, Webster MR, Kim S, et al
    Inhibition of age-related therapy resistance in melanoma by rosiglitazone-mediated induction of Klotho.
    Clin Cancer Res. 2017 Feb 23. pii: clincanres.0201.2017.
    PubMed     Text format     Abstract available


  6. EXLEY MA, Friedlander P, Alatrakchi N, Vriend L, et al
    Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: a Phase 1 Clinical Trial.
    Clin Cancer Res. 2017 Feb 13. pii: clincanres.0600.2016.
    PubMed     Text format     Abstract available


  7. BARONE A, Hazarika M, Theoret MR, Mishra-Kalyani P, et al
    FDA Approval Summary: Pembrolizumab for the Treatment of Patients with Unresectable or Metastatic Melanoma.
    Clin Cancer Res. 2017 Feb 8. pii: clincanres.0664.2016.
    PubMed     Text format     Abstract available


    January 2017
  8. DENIGER DC, Kwong ML, Pasetto A, Dudley ME, et al
    A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma.
    Clin Cancer Res. 2017;23:351-362.
    PubMed     Text format     Abstract available


  9. HAZARIKA M, Chuk MK, Theoret MR, Mushti S, et al
    U.S. FDA Approval Summary: Nivolumab for Treatment of Unresectable or Metastatic Melanoma Following Progression on Ipilimumab.
    Clin Cancer Res. 2017 Jan 13. pii: clincanres.0712.2016.
    PubMed     Text format     Abstract available


  10. BEAVER JA, Theoret MR, Mushti S, He K, et al
    FDA Approval of Nivolumab for the First-Line Treatment of Patients with BRAFV600 Wild-Type Unresectable or Metastatic Melanoma.
    Clin Cancer Res. 2017 Jan 10. pii: clincanres.0714.2016.
    PubMed     Text format     Abstract available


    November 2016
  11. GANNON P, Baumgaertner P, Huber A, Iancu EM, et al
    Rapid and continued T cell differentiation into long-term effector and memory stem cells in vaccinated melanoma patients.
    Clin Cancer Res. 2016 Nov 21. pii: clincanres.1708.2016.
    PubMed     Text format     Abstract available


  12. NAGARAJAN P, Curry JL, Ning J, Piao J, et al
    Tumor thickness and mitotic rate robustly predict melanoma-specific survival in patients with primary vulvar melanoma: A retrospective review of 100 cases.
    Clin Cancer Res. 2016 Nov 18. pii: clincanres.2126.2016.
    PubMed     Text format     Abstract available


  13. SANGIOLO D, Gammaitoni L, Giraudo L, Macagno M, et al
    Cytokine Induced Killer cells kill chemo-surviving melanoma cancer stem cells.
    Clin Cancer Res. 2016 Nov 4. pii: clincanres.1524.2016.
    PubMed     Text format     Abstract available


  14. KHALIL DN, Postow MA, Ibrahim N, Ludwig DL, et al
    An Open-Label, Dose-Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma.
    Clin Cancer Res. 2016;22:5204-5210.
    PubMed     Text format     Abstract available


    August 2016
  15. ROSE AA, Annis MG, Frederick DT, Biondini M, et al
    MAPK Pathway Inhibitors Sensitize BRAF Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB.
    Clin Cancer Res. 2016 Aug 11. pii: clincanres.1192.2016.
    PubMed     Text format     Abstract available


  16. XI L, Pham T, Payabyab EC, Sherry RM, et al
    Circulating Tumor DNA as an Early Indicator of Response to T-Cell Transfer Immunotherapy in Metastatic Melanoma.
    Clin Cancer Res. 2016 Aug 1. pii: clincanres.0613.2016.
    PubMed     Text format     Abstract available


    June 2016
  17. CARLINO MS, Long GV
    Ipilimumab Combined with Nivolumab: A Standard of Care for the Treatment of Advanced Melanoma?
    Clin Cancer Res. 2016 Jun 23. pii: clincanres.2944.2016.
    PubMed     Text format     Abstract available


  18. NIESSNER H, Schmitz J, Tabatabai G, Schmid A, et al
    PI3K pathway inhibition achieves potent antitumor activity in melanoma brain metastases in vitro and in vivo.
    Clin Cancer Res. 2016 Jun 15. pii: clincanres.0064.2016.
    PubMed     Text format     Abstract available


    May 2016
  19. WEIDE B, Martens A, Hassel JC, Berking C, et al
    Baseline biomarkers for outcome of melanoma patients treated with pembrolizumab.
    Clin Cancer Res. 2016 May 16. pii: clincanres.0127.2016.
    PubMed     Text format     Abstract available


  20. SADE-FELDMAN M, Kanterman J, Klieger Y, Ish-Shalom E, et al
    Clinical significance of circulating CD33+CD11b+HLA-DR- myeloid cells in Stage-IV melanoma patients treated with ipilimumab.
    Clin Cancer Res. 2016 May 13. pii: clincanres.3104.2015.
    PubMed     Text format     Abstract available


  21. MARTENS A, Wistuba-Hamprecht K, Yuan J, Postow MA, et al
    Increases in absolute lymphocytes and circulating CD4+ and CD8+ T cells are associated with positive clinical outcome of melanoma patients treated with ipilimumab.
    Clin Cancer Res. 2016 May 11. pii: clincanres.0249.2016.
    PubMed     Text format     Abstract available


  22. OTT PA, Hodi FS
    Talimogene Laherparepvec for the Treatment of Advanced Melanoma.
    Clin Cancer Res. 2016 May 4. pii: clincanres.2709.2016.
    PubMed     Text format     Abstract available


    April 2016
  23. KREPLER C, Xiao M, Sproesser K, Brafford PA, et al
    Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies.
    Clin Cancer Res. 2016;22:1592-602.
    PubMed     Text format     Abstract available


    March 2016
  24. ANDERSEN R, Donia M, Ellebaek E, Borch TH, et al
    Long-lasting complete responses in patients with metastatic melanoma after adoptive cell therapy with tumor-infiltrating lymphocytes and an attenuated IL-2 regimen.
    Clin Cancer Res. 2016 Mar 22. pii: clincanres.1879.2015.
    PubMed     Text format     Abstract available


  25. MADORE J, Strbenac D, Vilain R, Menzies AM, et al
    PD-L1 negative status is associated with lower mutation burden, differential expression of immune-related genes, and worse survival in stage-III melanoma.
    Clin Cancer Res. 2016 Mar 9. pii: clincanres.1714.2015.
    PubMed     Text format     Abstract available


  26. FIELD MG, Decatur CL, Kurtenbach S, Gezgin G, et al
    PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma.
    Clin Cancer Res. 2016;22:1234-42.
    PubMed     Text format     Abstract available


  27. KOHLHAPP FJ, Kaufman HL
    Molecular Pathways: Mechanism of Action for Talimogene Laherparepvec, a New Oncolytic Virus Immunotherapy.
    Clin Cancer Res. 2016;22:1048-54.
    PubMed     Text format     Abstract available


    February 2016
  28. HARTSOUGH EJ, Aplin AE
    Of Mice and Melanoma: PDX System for Modeling Personalized Medicine.
    Clin Cancer Res. 2016 Feb 3. pii: clincanres.3054.2016.
    PubMed     Text format     Abstract available


  29. CHARYCH DH, Hoch U, Langowski JL, Lee SR, et al
    NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models.
    Clin Cancer Res. 2016;22:680-90.
    PubMed     Text format     Abstract available


    January 2016
  30. MARTENS A, Wistuba-Hamprecht K, Geukes Foppen MH, Yuan J, et al
    Baseline peripheral blood biomarkers associated with clinical outcome of advanced melanoma patients treated with ipilimumab.
    Clin Cancer Res. 2016 Jan 19. pii: clincanres.2412.2015.
    PubMed     Text format     Abstract available


  31. EKMEKCIOGLU S, Davies MA, Tanese K, Roszik J, et al
    Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and its Expression Associates with Favorable Survival for Stage III Melanoma.
    Clin Cancer Res. 2016 Jan 18. pii: clincanres.2226.2015.
    PubMed     Text format     Abstract available


  32. VOGELSANG M, Martinez CN, Rendleman J, Bapodra AB, et al
    The expression quantitative trait loci in immune pathways and their effect on cutaneous melanoma prognosis.
    Clin Cancer Res. 2016 Jan 5. pii: clincanres.2066.2015.
    PubMed     Text format     Abstract available


    December 2015
  33. ROTHERMEL LD, Sabesan A, Stephens DJ, Chandran SS, et al
    Identification of an immunogenic subset of metastatic uveal melanoma.
    Clin Cancer Res. 2015 Dec 28. pii: clincanres.2294.2015.
    PubMed     Text format     Abstract available


  34. SCHREIBELT G, Bol KF, Westdorp H, Wimmers F, et al
    Effective clinical responses in metastatic melanoma patients after vaccination with primary myeloid dendritic cells.
    Clin Cancer Res. 2015 Dec 28. pii: clincanres.2205.2015.
    PubMed     Text format     Abstract available


  35. DAVAR D, Kirkwood JM
    CCR 20th Anniversary Commentary: MAPK/ERK Pathway Inhibition in Melanoma-Kinase Inhibition Redux.
    Clin Cancer Res. 2015;21:5412-5414.
    PubMed     Text format     Abstract available


  36. PIRES SILVA I, Salhi A, Giles KM, Vogelsang M, et al
    Identification of a novel pathogenic germline KDR variant in melanoma.
    Clin Cancer Res. 2015 Dec 2. pii: clincanres.1811.2015.
    PubMed     Text format     Abstract available


    November 2015
  37. HOOS A, Wolchok JD, Humphrey RW, Hodi FS, et al
    CCR 20th Anniversary Commentary: Immune-Related Response Criteria--Capturing Clinical Activity in Immuno-Oncology.
    Clin Cancer Res. 2015;21:4989-91.
    PubMed     Text format     Abstract available


    October 2015
  38. LEGAT A, Maby-El Hajjami H, Baumgaertner P, Cagnon L, et al
    Vaccination with LAG-3Ig (IMP321) and peptides induces specific CD4 and CD8 T-cell responses in metastatic melanoma patients - report of a phase I/IIa clinical trial.
    Clin Cancer Res. 2015 Oct 23. pii: clincanres.1212.2015.
    PubMed     Text format     Abstract available


  39. ZABOR EC, Heller G, Schwartz LH, Chapman PB, et al
    Correlating surrogate endpoints with overall survival at the individual patient level in BRAFV600E-mutated metastatic melanoma patients treated with vemurafenib.
    Clin Cancer Res. 2015 Oct 21. pii: clincanres.1441.2015.
    PubMed     Text format     Abstract available


  40. KONG Y, Si L, Li Y, Wu X, et al
    Analysis of mTOR Gene Aberrations in Melanoma Patients and Evaluation of Their Sensitivity to PI3K-AKT-mTOR Pathway Inhibitors.
    Clin Cancer Res. 2015 Oct 21. pii: clincanres.1110.2015.
    PubMed     Text format     Abstract available


  41. JACKSON CM, Kochel CM, Nirschl CJ, Durham NM, et al
    Systemic Tolerance Mediated by Melanoma Brain Tumors is Reversible by Radiotherapy and Vaccination.
    Clin Cancer Res. 2015 Oct 21. pii: clincanres.1516.2015.
    PubMed     Text format     Abstract available


  42. FREEMAN-KELLER M, Kim Y, Cronin H, Richards A, et al
    Nivolumab in Resected and Unresectable Metastatic Melanoma: Characteristics of Immune-Related Adverse Events and Association with Outcomes.
    Clin Cancer Res. 2015 Oct 7. pii: clincanres.1136.2015.
    PubMed     Text format     Abstract available


  43. GRANGE JM, Krone B
    Ancient Retrovirus Targeted by Engineered T Cells in Melanoma-Letter.
    Clin Cancer Res. 2015;21:4494.
    PubMed     Text format    


    August 2015
  44. WILSON MA, Zhao F, Khare S, D'Andrea K, et al
    Copy number changes are associated with response to treatment with carboplatin, paclitaxel, and sorafenib in melanoma.
    Clin Cancer Res. 2015 Aug 25. pii: clincanres.1162.2015.
    PubMed     Text format     Abstract available


  45. GEBHARDT C, Sevko A, Jiang H, Lichtenberger R, et al
    Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab.
    Clin Cancer Res. 2015 Aug 19. pii: clincanres.0676.2015.
    PubMed     Text format     Abstract available


    July 2015
  46. ANDREWS MC, Turner N, Boyd J, Roberts AW, et al
    Cellular mechanisms underlying complete hematological response of chronic myeloid leukemia to BRAF/MEK inhibition in a patient with concomitant metastatic melanoma.
    Clin Cancer Res. 2015 Jul 22. pii: clincanres.0393.2015.
    PubMed     Text format     Abstract available


  47. HONG D, Kurzrock R, Wheler JJ, Naing A, et al
    Phase I dose-escalation study of the multikinase inhibitor lenvatinib in patients with advanced solid tumors and in an expanded cohort of patients with melanoma.
    Clin Cancer Res. 2015 Jul 13. pii: clincanres.3063.2015.
    PubMed     Text format     Abstract available


  48. LIU Y, Hawkins OE, Vilgelm AE, Pawlikowski JS, et al
    Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models.
    Clin Cancer Res. 2015 Jul 7. pii: clincanres.0293.2015.
    PubMed     Text format     Abstract available


    June 2015
  49. HANNIFORD D, Zhong J, Koetz L, Gaziel-Sovran A, et al
    A miRNA-based signature detected in primary melanoma tissue predicts development of brain metastasis.
    Clin Cancer Res. 2015 Jun 18. pii: clincanres.2566.2014.
    PubMed     Text format     Abstract available


  50. SULLIVAN RJ, Flaherty KT
    New strategies in melanoma: entering the era of combinatorial therapy.
    Clin Cancer Res. 2015;21:2424-35.
    PubMed     Text format     Abstract available


  51. BOWERS JS, Nelson MH, Kundimi S, Bailey SR, et al
    Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling.
    Clin Cancer Res. 2015;21:2546-57.
    PubMed     Text format     Abstract available


    May 2015
  52. REED CM, Cresce ND, Mauldin IS, Slingluff CL Jr, et al
    Vaccination with Melanoma Helper Peptides Induces Antibody Responses Associated with Improved Overall Survival.
    Clin Cancer Res. 2015 May 12. pii: clincanres.0233.2015.
    PubMed     Text format     Abstract available


  53. TAUBE JM, Young GD, McMiller TL, Chen S, et al
    Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: implications for PD-1 pathway blockade.
    Clin Cancer Res. 2015 May 5. pii: clincanres.0244.2015.
    PubMed     Text format     Abstract available


  54. CARSON CC, Moschos SJ, Edmiston SN, Darr DB, et al
    IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma.
    Clin Cancer Res. 2015;21:2167-76.
    PubMed     Text format     Abstract available


    April 2015
  55. SULLIVAN RJ, Flaherty KT
    Pembrolizumab for Treatment of Patients with Advanced or Unresectable Melanoma.
    Clin Cancer Res. 2015 Apr 30. pii: clincanres.3061.2014.
    PubMed     Text format     Abstract available


    March 2015
  56. COOPER LJ, Krishnamurthy J, Rabinovich B, Mi T, et al
    Genetic Engineering of T cells to Target HERV-K, an Ancient Retrovirus on Melanoma.
    Clin Cancer Res. 2015 Mar 31. pii: clincanres.3197.2014.
    PubMed     Text format     Abstract available


  57. KLUGER H, Zito CR, Barr M, Baine M, et al
    Characterization of PD-L1 Expression and Associated T cell Infiltrates in Metastatic Melanoma Samples from Variable Anatomic Sites.
    Clin Cancer Res. 2015 Mar 18. pii: clincanres.3073.2014.
    PubMed     Text format     Abstract available


  58. RODRIGUEZ-GARCIA A, Gimenez-Alejandre M, Rojas JJ, Moreno R, et al
    Safety and efficacy of VCN-01, an oncolytic adenovirus combining fiber HSG-binding domain replacement with RGD and hyaluronidase expression.
    Clin Cancer Res. 2015;21:1406-18.
    PubMed     Text format     Abstract available


  59. ROBBINS PF, Kassim SH, Tran TL, Crystal JS, et al
    A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response.
    Clin Cancer Res. 2015;21:1019-27.
    PubMed     Text format     Abstract available


    February 2015
  60. CARVAJAL RD, Lawrence DP, Weber J, Gajewski TF, et al
    Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition.
    Clin Cancer Res. 2015 Feb 18. pii: clincanres.1630.2014.
    PubMed     Text format     Abstract available


  61. ZHANG L, Morgan RA, Beane JD, Zheng Z, et al
    Tumor Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma.
    Clin Cancer Res. 2015 Feb 18. pii: clincanres.2085.2014.
    PubMed     Text format     Abstract available


  62. MIN L, Hodi FS, Giobbie-Hurder A, Ott PA, et al
    Systemic high-dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: a retrospective cohort study.
    Clin Cancer Res. 2015;21:749-55.
    PubMed     Text format     Abstract available


  63. CHACON JA, Sarnaik AA, Chen JQ, Creasy C, et al
    Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy.
    Clin Cancer Res. 2015;21:611-21.
    PubMed     Text format     Abstract available


    January 2015
  64. WANG T, Xiao M, Ge Y, Krepler C, et al
    BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth.
    Clin Cancer Res. 2015 Jan 23. pii: clincanres.1554.2014.
    PubMed     Text format     Abstract available


  65. SCOLYER RA, Kakavand H, Wilmott JS, Menzies AM, et al
    PD-L1 expression and tumor-infiltrating lymphocytes define different subsets of MAPK inhibitor treated melanoma patients.
    Clin Cancer Res. 2015 Jan 21. pii: clincanres.2023.2014.
    PubMed     Text format     Abstract available


  66. LASSEN UN, Meulendijks D, Siu LL, Karanikas V, et al
    A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers.
    Clin Cancer Res. 2015;21:258-66.
    PubMed     Text format     Abstract available


  67. GERAMI P, Cook RW, Wilkinson J, Russell MC, et al
    Development of a prognostic genetic signature to predict the metastatic risk associated with cutaneous melanoma.
    Clin Cancer Res. 2015;21:175-83.
    PubMed     Text format     Abstract available


    December 2014
  68. GIBNEY GT, Kudchadkar RR, DeConti RC, Thebeau MS, et al
    Safety, correlative markers and clinical results of adjuvant nivolumab in combination with vaccine in resected high-risk metastatic melanoma.
    Clin Cancer Res. 2014 Dec 18. pii: clincanres.2468.2014.
    PubMed     Text format     Abstract available


  69. HUTCHINSON KE, Ross JS, Stephens PJ, Miller VA, et al
    Melanoma BRAF Fusions-Response.
    Clin Cancer Res. 2014;20:6632.
    PubMed     Text format    


  70. BOTTON T, Yeh I, Bastian BC
    Melanoma BRAF Fusions-Letter.
    Clin Cancer Res. 2014;20:6631.
    PubMed     Text format    


    November 2014
  71. CHANDRAN SS, Paria BC, Srivastava AK, Rothermel LD, et al
    Persistence of CTL clones targeting melanocyte differentiation antigens was insufficient to mediate significant melanoma regression in humans.
    Clin Cancer Res. 2014 Nov 25. pii: clincanres.2208.2014.
    PubMed     Text format     Abstract available


  72. CARLINO MS, Fung C, Shahheydari H, Todd JR, et al
    Pre-existing MEK1P124 mutations diminish response to BRAF inhibitors in metastatic melanoma patients.
    Clin Cancer Res. 2014 Nov 4. pii: clincanres.0759.2014.
    PubMed     Text format     Abstract available


    May 2014
  73. JOHNSON GL, Stuhlmiller TJ, Angus SP, Zawistowski JS, et al
    Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancer.
    Clin Cancer Res. 2014;20:2516-22.
    PubMed     Text format     Abstract available


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