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The Medical Article of the Year 2008


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Articles published in Antimicrob Agents Chemother

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    June 2008
  1. MARTINS-LEITE P , Gazzinelli G, Alves-Oliveira LF, Gazzinelli A, et al
    Effect of Chemotherapy with Praziquantel on the Production of Cytokines and Morbidity associated with Schistosomiasis mansoni.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  2. DORLO TP , van Thiel PP, Huitema AD, Keizer RJ, et al
    Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  3. ARRIGHI RB , Ebikeme C, Jiang Y, Ranford-Cartwright L, et al
    The cell penetrating peptide TP10 shows broad spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


    May 2008
  4. HENRY M , Briolant S, Fontaine A, Mosnier J, et al
    In Vitro Activity of Ferroquine is Independent of Polymorphisms in Transport Proteins Genes Implicated in Quinoline Resistance in Plasmodium falciparum.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  5. RIBEIRO RR , Moura EP, Pimentel VM, Sampaio WM, et al
    Reduced tissue parasitic load and infectivity to sand flies in dogs naturally infected by Leishmania (Leishmania) chagasi following treatment with a liposome formulation of meglumine antimoniate.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


    April 2008
  6. LEK-UTHAI U , Suwanarusk R, Ruengweerayut R, Skinner-Adams TS, et al
    HIV-1 protease inhibitors and clinical isolates of Plasmodium: Greater activity against P. vivax than P. falciparum.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  7. HE Z , Qin L, Chen L, Peng N, et al
    Synergy of Human Immunodeficiency Virus Protease Inhibitors with Chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  8. SULSEN VP , Frank FM, Cazorla SI, Anesini CA, et al
    Trypanocidal and Leishmanicidal Activities of Sesquiterpene Lactones from Ambrosia tenuifolia Sprengel (Asteraceae).
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  9. LISK G , Pain M, Gluzman IY, Kambhampati S, et al
    Changes in PSAC Reduce Leupeptin Uptake and Can Confer Drug Resistance in P. falciparum-Infected Erythrocytes.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  10. MEHLOTRA RK , Mattera G, Bockarie MJ, Maguire JD, et al
    Discordant patterns of genetic variation at two chloroquine-resistant loci in worldwide populations of malaria parasite Plasmodium falciparum.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  11. SAVINI H , Bogreau H, Bertaux L, Bouchiba H, et al
    First Case of Emergence of Atovaquone-Proguanil (MalaroneTM) Resistance in Plasmodium falciparum During Treatment in Traveller from Comoros.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


    March 2008
  12. GELHAUS C , Jacobs T, Andra J, Leippe M, et al
    The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic Plasmodium falciparum.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  13. ROBERTS L , Egan TJ, Joiner KA, Hoppe HC, et al
    DIFFERENTIAL EFFECTS OF QUINOLINE ANTI-MALARIALS ON ENDOCYTOSIS IN PLASMODIUM FALCIPARUM.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


    February 2008
  14. BORRMANN S , Matsiegui PB, Missinou MA, Kremsner PG, et al
    The effects of Plasmodium falciparum parasite population size and patient age on early and late parasitological outcomes of antimalarial treatment in children.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  15. KOBBE R , Schreiber N, May J, Jacobs T, et al
    Simvastatin treatment shows no effect on the incidence of cerebral malaria or parasitemia during experimental malaria.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


    January 2008
  16. JOHNSON DJ , Owen A, Plant N, Bray PG, et al
    Drug-regulated gene expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


  17. TARNING J , Ashley EA, Lindegardh N, Stepniewska K, et al
    Population pharmacokinetics of piperaquine after two different treatment regimens of dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand.
    Antimicrob Agents Chemother. 2008;.
    PubMed     Related articles    Abstract available


    December 2007
  18. FADILI KE , Imbeault M, Messier N, Roy G, et al
    Modulation of gene expression in human macrophages treated with the anti-Leishmania pentavalent antimonial drug Pentostam.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


  19. BASU JM , Mookerjee A, Banerjee R, Saha M, et al
    Inhibition of ABC Transporters Abolishes Antimony Resistance in Leishmania Infection.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


  20. BARTHEL D , Schlitzer M, Pradel G
    Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


    October 2007
  21. BUCHHOLZ K , Schirmer RH, Eubel JK, Akoachere MB, et al
    Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  22. PALIT P , Ali N
    Oral Therapy with Amlodipine and Lacidipine, 1, 4-Dihydropyridine Derivatives, Show Antileishmanial Activity against Experimental Visceral Leishmaniasis.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  23. LEGRAND E , Volney B, Meynard JB, Mercereau-Puijalon O, et al
    In vitro monitoring of Plasmodium falciparum drug resistance in French Guiana: a synopsis of continuous assessment over the years 1994-2005.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  24. CHEN N , Gao Q, Wang S, Wang G, et al
    No genetic bottle-neck in Plasmodium falciparum wild type pfcrt alleles re-emerging in Hainan Island, China following high-level chloroquine resistance.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  25. VINAYAK S , Alam MT, Upadhyay M, Das MK, et al
    Extensive Genetic Diversity in the Plasmodium falciparum Na+/H+ Exchanger-1 Transporter Protein Implicated in Quinine Resistance.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  26. SEIFERT K , Lemke A, Croft SL, Kayser O, et al
    Anti-leishmanial structure-activity-relationships of synthetic phospholipids: in vitro and in vivo activity of selected derivatives.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


    September 2007
  27. JAPRUNG D , Leartsakulpanich U, Chusacultanachai S, Yuthavong Y, et al
    Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 drug combination.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  28. KELLY JX , Smilkstein MJ, Cooper RA, Lane KD, et al
    Design, Synthesis, and Evaluation of 10-N-substituted Acridones as Novel Chemosensitizers in Plasmodium falciparum.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


    August 2007
  29. DAHL EL , Rosenthal PJ
    MULTIPLE ANTIBIOTICS EXERT DELAYED EFFECTS AGAINST THE PLASMODIUM FALCIPARUM APICOPLAST.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


    July 2007
  30. VAN VOORHIS WC , Rivas KL, Bendale P, Nallan L, et al
    Tetrahydroquinoline Plasmodium falciparum protein farnesyltransferase inhibitors: Efficacy, pharmacokinetics, and metabolism.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


    June 2007
  31. EHRHARDT S , Eggelte TA, Kaiser S, Adjei L, et al
    Large scale surveillance of Plasmodium falciparum pfcrtK76T in northern Ghana.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  32. NSOBYA SL , Dokomajilar C, Joloba M, Dorsey G, et al
    Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


    May 2007
  33. WAGHABI MC , Keramidas M, Calvet CM, Meuser M, et al
    SB-431542, A TRANSFORMING GROWTH FACTOR {beta} INHIBITOR, IMPAIRS TRYPANOSOMA CRUZI INFECTION IN CARDIOMYOCYTES AND PARASITE CYCLE COMPLETION.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


  34. PRADINES B , Torrentino-Madamet M, Fontaine A, Henry M, et al
    Atorvastatin is Ten-fold More Active in Vitro than other Statins against Plasmodium falciparum.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  35. SHARMA S , Sharma SK, Modak R, Karmodiya K, et al
    A mass spectrometry based systems approach for the identification of inhibitors of Plasmodium falciparum fatty acid synthase.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


    April 2007
  36. COELHO AC , Messier N, Ouellette M, Cotrim PC, et al
    Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


  37. LEGRAND E , Demar M, Volney B, Ekala MT, et al
    A first case of emergence of Atovaquone-Proguanil Plasmodium falciparum resistance during second line Malarone treatment in South America.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


  38. FIVELMAN QL , Adagu IS, Warhurst DC
    Effects of piperaquine, chloroquine and amodiaquine on drug uptake and in combination with dihydroartemisinin against drug sensitive and resistant Plasmodium falciparum strains.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


    March 2007
  39. MUKHERJEE S , Ukil A, Das PK
    Immunomodulatory Peptide from Cystatin, a Natural Cysteine Protease Inhibitor, using Leishmaniasis as Model Macrophage Disease.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


    February 2007
  40. OYAKHIROME S , Issifou S, Pongratz P, Barondi F, et al
    Fosmidomycin-Clindamycin versus Sulfadoxine-Pyrimethamine in the Treatment of Plasmodium falciparum Malaria: A Randomized Controlled Trial.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


  41. SOWUNMI A , Balogun T, Gbotosho GO, Happi CT, et al
    Activities of amodiaquine, artesunate, and artesunate-amodiaquine against asexual- and -sexual stage parasites in falciparum malaria in children.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


  42. KYRIACOU HM , Steen KE, Raza A, Arman M, et al
    In vitro inhibition of Plasmodium falciparum rosette formation by curdlan sulphate.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  43. MCCOLLUM AM , Mueller K, Villegas L, Udhayakumar V, et al
    Common origin and fixation of Plasmodium falciparum dhfr and dhps mutations associated with sulphadoxine-pyrimethamine resistance in a low transmission area in South America.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


  44. LUQUE-ORTEGA JR , Rivas L
    Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  45. XIAO SH , Keiser J, Chollet J, Utzinger J, et al
    The in vitro and in vivo activities of synthetic trioxolanes on major human schistosome species.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


    January 2007
  46. SALEH A , Friesen J, Baumeister S, Gross U, et al
    Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by Nanomolar Concentrations of HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone): a High Affinity Inhibitor of Alternative (type II) NADH Dehydrogenases.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  47. RAKOTOMANGA M , Blanc S, Gaudin K, Chaminade P, et al
    Miltefosine affects the Lipid Metabolism in Leishmania donovani Promastigotes.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  48. MITA T , Tanabe K, Takahashi N, Tsukahara T, et al
    Independent evolution of pyrimethamine resistance in Plasmodium falciparum in Melanesia.
    Antimicrob Agents Chemother. 2007;.
    PubMed     Related articles    Abstract available


    December 2006
  49. HUMPHREYS GS , Merinopoulos I, Ahmed J, Whitty CJ, et al
    AMODIAQUINE AND ARTEMETHER-LUMEFANTRINE SELECT DISTINCT ALLELES OF THE PLASMODIUM FALCIPARUM PFMDR1 GENE IN TANZANIAN CHILDREN TREATED FOR UNCOMPLICATED MALARIA.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  50. ALAM MT , Bora H, Bharti PK, Saifi MA, et al
    Similar Trends of Pyrimethamine Resistance Associated Mutations in Plasmodium vivax and P. falciparum.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  51. WONG IL , Chan KF, Burkett BA, Zhao Y, et al
    Flavonoid Dimers as Bivalent Modulators for Pentamidine and Sodium Stiboglucanate Resistance in Leishmania.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  52. KEISER J , Shu-Hua X, Chollet J, Tanner M, et al
    Evaluation of in Vivo Activity of Tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis and Opisthorchis viverrini.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  53. EKSI S , Czesny B, van Gemert GJ, Sauerwein RW, et al
    Inhibition of Plasmodium falciparum oocyst production by membrane permeant cysteine protease inhibitor, E64d.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  54. CHOUBEY V , Maity P, Guha M, Kumar S, et al
    Inhibition of Plasmodium falciparum choline kinase by hexadecyltrimethylammonium bromide: A possible antimalarial mechanism of hexadecyltrimethylammonium bromide.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  55. CUI L , Miao J, Cui L
    Cytotoxic Effect of Curcumin on Malaria Parasite Plasmodium falciparum: Inhibition of Histone Acetylation and Generation of Reactive Oxygen Species.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


    November 2006
  56. KWIEK JJ , Alker AP, Wenink EC, Chaponda M, et al
    Estimating True Antimalarial Efficacy by Heteroduplex Tracking Assay in Patients with Complex Plasmodium falciparum Infections.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  57. ROBERTS SC , Jiang Y, Gasteier J, Frydman B, et al
    Leishmania donovani Polyamine Biosynthetic Enzyme Overproducers as Tools to Investigate the Mode of Action of Cytotoxic Polyamine Analogs.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  58. BANIECKI ML , Wirth DF, Clardy J
    A High-Throughput Plasmodium falciparum Growth Assay for Malaria Drug Discovery.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  59. MOCKENHAUPT FP , Bedu-Addo G, Junge C, Hommerich L, et al
    Markers of sulfadoxine-pyrimethamine resistant falciparum malaria in placenta and circulation of pregnant women.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available   Free Full Text


  60. PONTE-SUCRE A , Faber JH, Gulder T, Kajahn I, et al
    Activity of Naphthylisoquinoline Alkaloids and Synthetic Analogs against Leishmania major.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available   Free Full Text


  61. SKINNER-ADAMS TS , Andrews KT, Melville L, McCarthy J, et al
    Synergistic interactions of antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  62. MENEZ C , Buyse M, Besnard M, Farinotti R, et al
    Interaction between miltefosine and amphotericin B: consequences for their activities towards intestinal epithelial cells and Leishmania donovani promastigotes in vitro.
    Antimicrob Agents Chemother. 2006;50:3793-800.
    PubMed     Related articles    Abstract available


    October 2006
  63. RAMYA TN , Mishra S, Karmodiya K, Surolia N, et al
    Inhibitors of Non-Housekeeping Functions of the Apicoplast Defy 'Delayed Death' in Plasmodium falciparum.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available   Free Full Text


  64. SERRANO-MARTIN X , Payares G, Mendoza-Leon A
    Glibenclamide, a blocker of K+ATP channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis.
    Antimicrob Agents Chemother. 2006;.
    PubMed     Related articles    Abstract available


  65. KADDOURI H , Nakache S, Houze S, Mentre F, et al
    Assessment of the Drug Susceptibility of Plasmodium falciparum Clinical Isolates from Africa by Using a Plasmodium Lactate Dehydrogenase Immunodetection Assay and an Inhibitory Maximum Effect Model for Precise Measurement of the 50-Percent Inhibitory
    Antimicrob Agents Chemother. 2006;50:3343-9.
    PubMed     Related articles    Abstract available


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