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Articles published in Antimicrob Agents Chemother

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    March 2010
  1. LIM P , Wongsrichanalai C, Chim P, Khim N, et al
    Decreased in vitro susceptibility of Plasmodium falciparum Isolates to artesunate, mefloquine, chloroquine and quinine in Cambodia from 2001 to 2007.
    Antimicrob Agents Chemother. 2010.
    PubMed     Text format     Related articles    Abstract available


    February 2010
  2. WITKOWSKI B , Lelievre J, Lopez Barragan MJ, Laurent V, et al
    Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism.
    Antimicrob Agents Chemother. 2010.
    PubMed     Text format     Related articles    Abstract available


  3. LACKOVIC K , Parisot JP, Sleebs N, Baell JB, et al
    Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small Molecule Chemical Library.
    Antimicrob Agents Chemother. 2010.
    PubMed     Text format     Related articles    Abstract available


  4. GRIEWANK K , Gazeau C, Eichhorn A, von Stebut E, et al
    Miltefosine efficiently eliminates Leishmania major amastigotes from infected murine dendritic cells without altering their immune functions.
    Antimicrob Agents Chemother. 2010;54:652-9.
    PubMed     Text format     Related articles    Abstract available


    January 2010
  5. NSOBYA SL , Kiggundu M, Nanyunja S, Joloba M, et al
    In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.
    Antimicrob Agents Chemother. 2010.
    PubMed     Text format     Related articles    Abstract available


    December 2009
  6. MIXSON-HAYDEN T , Jain V, McCollum AM, Poe A, et al
    Evidence of Selective Sweeps in Genes Conferring Resistance to Chloroquine and Pyrimethamine in Plasmodium falciparum within India.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  7. LECOEUR H , Buffet PA, Milon G, Lang T, et al
    Early curative applications of aminoglycosides (WR279396) on experimental Leishmania major-loaded cutaneous site do not impair the acquisition of immunity.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


    October 2009
  8. CORINE K , Imwong M, Fanello CI, Stepniewska K, et al
    Molecular correlates of high level antifolate resistance in Rwandan children with Plasmodium falciparum malaria.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  9. HELD J , Westerman R, Kremsner PG, Mordmuller B, et al
    In vitro activity of mirincamycin (U24729A) in Plasmodium falciparum isolates from Gabon.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  10. GRIMALDI G JR , Porrozzi R, Friedrich K, Teva A, et al
    Comparative efficacy of two antimony regimens to treat Leishmania braziliensis-induced cutaneous leishmaniasis in rhesus macaques (Macaca mulatta).
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  11. SERRANO-MARTIN X , Payares G, De Lucca M, Martinez JC, et al
    Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


    September 2009
  12. LUMB V , Das MK, Singh N, Dev V, et al
    Characteristic of genetic hitchhiking around Plasmodium falciparum dihydrofolate reductase (dhfr) gene associated with pyrimethamine resistance, in India.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  13. MENDEZ S , Traslavina R, Hinchman M, Huang L, et al
    The antituberculosis drug pyrazinamide affects the course of cutaneous leishmaniasis in vivo and increases macrophage and dendritic cell activation.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  14. MWAI L , Kiara SM, Abdirahman A, Pole L, et al
    In vitro activity of piperaquine, lumefantrine and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in Pfcrt and Pfmdr1.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  15. MOURA PA , Dame JB, Fidock DA
    Evaluation of the Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  16. INOCENCIO DA LUZ R , Vermeersch M, Dujardin JC, Cos P, et al
    In vitro sensitivity testing of Leishmania clinical field isolates: pre-conditioning of promastigotes enhances infectivity for macrophage host cells.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


    August 2009
  17. ANDRIANTSOANIRINA V , Ratsimbasoa A, Bouchier C, Jahevitra M, et al
    P. falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  18. BOTROS SS , William S, Beadle JR, Valiaeva N, et al
    Antischistosomal Activity of Hexadecyloxypropyl cyclic HPMPA and Other Alkoxyalkyl Esters of Acyclic Nucleoside Phosphonates Assessed by Schistosome Worm Killing in vitro.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  19. BERTAUX L , Hong Quang L, Sinou V, Xuan Thanh N, et al
    New PfATP6 mutations found in Plasmodium falciparum isolates from Vietnam.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  20. CZESNY B , Goshu S, Cook JL, Williamson KC, et al
    Proteasome inhibitor, epoxomicin, has potent P. falciparum gametocytocidal activity.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  21. OMODEO-SALE F , Cortelezzi L, Basilico N, Casagrande M, et al
    Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum parasitized human erythrocytes.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


    July 2009
  22. BOISSIER J , Cosledan F, Robert A, Meunier B, et al
    Evaluation of the in vitro activity of Trioxaquines(R) against Schistosoma mansoni.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  23. JIMENEZ-DIAZ MB , Mulet T, Viera S, Gomez V, et al
    Improved murine model of malaria using P. falciparum competent strains and non-myelodepleted NOD-scid IL2R{gamma}null mice engrafted with human erythrocytes.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


    June 2009
  24. TARNING J , McGready R, Lindegardh N, Ashley EA, et al
    Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated P. falciparum malaria.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  25. VERMEERSCH M , Inocencio da Luz R, Tote K, Timmermans JP, et al
    In vitro susceptibility of Leishmania donovani promastigote and amastigote stages to antileishmania reference drugs: practical relevance of stage-specific differences.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  26. DAO NV , Quoc NP, Ngoa ND, Thuy LT, et al
    Pharmacokinetics and Ex Vivo Pharmacodynamic Antimalarial Activity of Dihydroartemisinin-Piperaquine in Patients with Uncomplicated Falciparum Malaria in Vietnam.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  27. KIARA SM , Okombo J, Masseno V, Mwai L, et al
    In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from Kenyan coast: Emergence of parasites with Ile-164-Leu mutation.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  28. OBALDIA N 3RD , Kotecka BM, Edstein MD, Haynes RK, et al
    Evaluation of Artemisone Combinations in Aotus Monkeys infected with Plasmodium falciparum.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


    May 2009
  29. SUTHERLAND CJ , Fifer H, Pearce RJ, Bin Reza F, et al
    Novel pfdhps haplotypes among imported cases of Plasmodium falciparum malaria in the UK.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


    April 2009
  30. MOORE BR , Ilett KF, Page-Sharp M, Jago JD, et al
    Investigation of Piperaquine Pharmacodynamics and Parasite Viability in a Murine Malaria Model.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  31. DAHLSTROM S , Veiga MI, Martensson A, Bjorkman A, et al
    Polymorphism in pfMRP1 (Plasmodium falciparum multidrug resistance protein 1) amino acid 1466 associated with resistance to sulfadoxine-pyrimethamine treatment.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  32. HOLLOWAY GA , Charman WN, Fairlamb AH, Brun R, et al
    Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  33. MASSENO V , Muriithi S, Nzila A
    In-vitro chemosensitization of Plasmodim falciparum to antimalarials by verapamil and probenecid.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  34. ALKER AP , Juliano JJ, Meshnick SR, Owen A, et al
    Plasmodium falciparum and dihydrofolate reductase I164L mutations in Africa.
    Antimicrob Agents Chemother. 2009;53:1722.
    PubMed     Text format     Related articles   


    March 2009
  35. ROY A , Bosedasgupta S, Ganguly A, Jaisankar P, et al
    Topoisomerase I gene mutations at F270 in the large subunit and at N184 in the small subunit contribute to the resistance mechanism of unicellular parasite Leishmania donovani towards 3,3'-Diindolylmethane (DIM).
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  36. PARQUET V , Briolant S, Torrentino-Madamet M, Henry M, et al
    Atorvastatin is a Promising Partner for Antimalarial Drugs in Treatment of Plasmodium falciparum Malaria.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  37. LEPROHON P , Legare D, Ouellette M
    Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  38. HENRY M , Briolant S, Zettor A, Pelleau S, et al
    Plasmodium falciparum Na+/H+ Exchanger 1 Transporter is Involved in Reduced Susceptibility to Quinine.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


    February 2009
  39. JAAFARI MR , Bavarsad N, Fazly Bazzaz BS, Samiei A, et al
    The Effect of Topical Liposomes Containing Paromomycin Sulfate (PM) in the Course of Leishmania major Infection in Susceptible BALB/c Mice.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  40. SANCHEZ-CANETE MP , Carvalho L, Perez-Victoria FJ, Gamarro F, et al
    The low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


    January 2009
  41. PREECHAPORNKUL P , Imwong M, Chotivanich K, Pongtavornpinyo W, et al
    Plasmodium Falciparum Pfmdr1 Amplification, Mefloquine Resistance, and Parasite Fitness.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


  42. SERRANO-MARTIN X , Garcia-Marchan Y, Fernandez A, Rodriguez N, et al
    Amiodarone destabilizes the intracellular Ca2+ homeostasis and the biosynthesis of sterols in Leishmania mexicana.
    Antimicrob Agents Chemother. 2009.
    PubMed     Text format     Related articles    Abstract available


    December 2008
  43. GNANASEKAR M , Salunkhe AM, Mallia AK, He YX, et al
    Praziquantel affects the regulatory myosin light chain of Schistosoma mansoni.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


  44. HAPPI CT , Gbotosho GO, Folarin OA, Sowunmi A, et al
    Selection of Plasmodium falciparum Multidrug Resistance Gene 1 Alleles in Asexual stages and Gametocytes by Artemether-Lumefantrine in Nigerian Children with Uncomplicated Falciparum Malaria.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


  45. BRIOLANT S , Baragatti M, Parola P, Simon F, et al
    A Multi-Normal in Vitro Distribution Model Suitable for the Distribution of Plasmodium falciparum Chemosusceptibility to Doxycycline.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


    November 2008
  46. KUMAR D , Kulshrestha A, Singh R, Salotra P, et al
    In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and Amphotericin B: correlation with SAG susceptibility and implications in the endemic area.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


  47. RODRIGUES RF , Charret KS, da Silva EF, Echevarria A, et al
    Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


    October 2008
  48. LEHANE AM , Kirk K
    Chloroquine-resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


    September 2008
  49. GOYENECHE-PATINO DA , Valderrama L, Walker J, Saravia NG, et al
    Antimony Resistance and Trypanothione in Experimentally Selected and Clinical Strains of Leishmania panamensis.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


  50. LOPEZ-MARTIN C , Perez-Victoria JM, Carvalho L, Castanys S, et al
    Sitamaquine sensitivity in Leishmania is not mediated by drug accumulation in acidocalcisomes.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


  51. FERNANDES RODRIGUES JC , Concepcion JL, Rodrigues C, Caldera A, et al
    In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical and ultrastructural effects.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


  52. MCCOLLUM AM , Basco LK, Tahar R, Udhayakumar V, et al
    Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistant alleles in a population from central Africa.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


  53. CUNNINGHAM E , Drag M, Kafarski P, Bell A, et al
    Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors.
    Antimicrob Agents Chemother. 2008;52:3221-8.
    PubMed     Text format     Related articles    Abstract available


    August 2008
  54. OCHONG E , Bell DJ, Johnson DJ, D'Alessandro U, et al
    Plasmodium falciparum harbouring DHFR I164L are absent in Malawi and Zambia even under antifolate drug pressure.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


  55. MARTINEZ-ROJANO H , Mancilla-Ramirez J, Quinonez-Diaz L, Galindo-Sevilla N, et al
    Anti-leishmanial activity of Hydroxyurea on Leishmania mexicana.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


    July 2008
  56. ALZATE JF , Arias A, Mollinedo F, Rico E, et al
    Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


  57. CASTANYS-MUNOZ E , Perez-Victoria JM, Gamarro F, Castanys S, et al
    Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement.
    Antimicrob Agents Chemother. 2008.
    PubMed     Text format     Related articles    Abstract available


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