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  Parkinson's Disease

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Articles published in J Biol Chem

Retrieve available abstracts of 25 articles:
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Single Articles


    August 2017
  1. AMIREDDY N, Puttapaka SN, Vinnakota RL, Ravuri HG, et al
    The Unintended Mitochondrial Uncoupling Effects of the FDA Approved Anti-Helminth Drug Nitazoxanide Mitigates Experimental Parkinsonism in Mice.
    J Biol Chem. 2017 Aug 10. pii: jbc.M117.791863. doi: 10.1074/jbc.M117.791863.
    PubMed     Text format     Abstract available


    June 2017
  2. DHAVALE DD, Tsai C, Bagchi DP, Engel LA, et al
    A sensitive assay reveals structural requirements for alpha-synuclein fibril growth.
    J Biol Chem. 2017;292:9034-9050.
    PubMed     Text format     Abstract available


    May 2017
  3. YOSHIMURA Y, Holmberg MA, Kukic P, Andersen CB, et al
    MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions.
    J Biol Chem. 2017;292:8269-8278.
    PubMed     Text format     Abstract available


    April 2017
  4. DE FRANCESCHI G, Fecchio C, Sharon R, Schapira AHV, et al
    alpha-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection.
    J Biol Chem. 2017;292:6927-6937.
    PubMed     Text format     Abstract available


    November 2016
  5. PFAFF DH, Fleming T, Nawroth P, Teleman AA, et al
    Evidence against a role for the Parkinsonism-associated protein DJ-1 in methylglyoxal detoxification.
    J Biol Chem. 2016 Nov 30. pii: jbc.M116.743823.
    PubMed     Text format     Abstract available


    September 2016
  6. YANG X, Mudgett J, Bou-About G, Champy MF, et al
    Physiological Expression of AMPKgamma2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.
    J Biol Chem. 2016 Sep 12. pii: jbc.M116.738591.
    PubMed     Text format     Abstract available


    July 2016
  7. OIKAWA T, Nonaka T, Terada M, Tamaoka A, et al
    alpha-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly.
    J Biol Chem. 2016;291:15046-56.
    PubMed     Text format     Abstract available


  8. FOLLETT J, Bugarcic A, Yang Z, Ariotti N, et al
    Parkinson's disease linked Vps35 R524W mutation impairs the endosomal association of retromer and induces alpha-synuclein aggregation.
    J Biol Chem. 2016 Jul 6. pii: jbc.M115.703157.
    PubMed     Text format     Abstract available


    June 2016
  9. KUMAR AS, Jagadeeshan S, Subramanian A, Chidambaram SB, et al
    Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor.
    J Biol Chem. 2016;291:12310-21.
    PubMed     Text format     Abstract available


    May 2016
  10. CHANDRA G, Rangasamy SB, Roy A, Kordower JH, et al
    Neutralization of regulated on activation, normal T cell expressed and secreted and eotaxin prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease.
    J Biol Chem. 2016 May 12. pii: jbc.M116.714824.
    PubMed     Text format     Abstract available


  11. LIU K, Li F, Han H, Chen Y, et al
    Parkin Regulates the Activity of Pyruvate Kinase M2.
    J Biol Chem. 2016;291:10307-17.
    PubMed     Text format     Abstract available


    March 2016
  12. FILOGRANA R, Godena VK, Sanchez-Martinez A, Ferrari E, et al
    SOD-mimetic M40403 is protective in cell and fly models of paraquat toxicity: Implications for Parkinson disease.
    J Biol Chem. 2016 Mar 7. pii: jbc.M115.708057.
    PubMed     Text format     Abstract available


    February 2016
  13. SAMUEL F, Flavin WP, Iqbal S, Pacelli C, et al
    Effects of Serine 129 Phosphorylation on alpha-Synuclein Aggregation, Membrane Association, and Internalization.
    J Biol Chem. 2016;291:4374-85.
    PubMed     Text format     Abstract available


    January 2016
  14. HAM SJ, Lee SY, Song S, Chung JR, et al
    Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.
    J Biol Chem. 2016;291:1803-16.
    PubMed     Text format     Abstract available


  15. KIM H, Yang J, Kim MJ, Choi S, et al
    Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria.
    J Biol Chem. 2016;291:1841-53.
    PubMed     Text format     Abstract available


    December 2015
  16. PARK G, Tan J, Garcia G, Kang Y, et al
    Regulation of Histone Acetylation by Autophagy in Parkinson Disease.
    J Biol Chem. 2015 Dec 23. pii: jbc.M115.675488.
    PubMed     Text format     Abstract available


    November 2015
  17. MOREE B, Yin G, Lazaro DF, Munari F, et al
    Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric alpha-Synuclein and Reduce Its Aggregation in Cells.
    J Biol Chem. 2015;290:27582-93.
    PubMed     Text format     Abstract available


  18. FOLLMER C, Coelho-Cerqueira E, Yatabe-Franco DY, Araujo GD, et al
    Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of alpha-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).
    J Biol Chem. 2015;290:27660-79.
    PubMed     Text format     Abstract available


    August 2015
  19. DAHER JP, Abdelmotilib HA, Hu X, Volpicelli-Daley LA, et al
    Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates alpha-Synuclein Gene-induced Neurodegeneration.
    J Biol Chem. 2015;290:19433-44.
    PubMed     Text format     Abstract available


    June 2015
  20. ROSTOVTSEVA TK, Gurnev PA, Protchenko O, Hoogerheide DP, et al
    alpha-Synuclein Shows High-Affinity Interaction with Voltage-Dependent Anion Channel Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease.
    J Biol Chem. 2015 Jun 8. pii: jbc.M115.641746.
    PubMed     Text format     Abstract available


    May 2015
  21. NORRIS KL, Hao R, Chen LF, Lai CH, et al
    Convergence of Parkin, PINK1, and alpha-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.
    J Biol Chem. 2015;290:13862-74.
    PubMed     Text format     Abstract available


  22. CHAUDHURI AD, Kabaria S, Choi DC, Mouradian MM, et al
    MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death.
    J Biol Chem. 2015;290:12425-34.
    PubMed     Text format     Abstract available


    April 2015
  23. HAN JY, Kang MJ, Kim KH, Han PL, et al
    Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy.
    J Biol Chem. 2015;290:10325-35.
    PubMed     Text format     Abstract available


    March 2015
  24. CHERUVARA H, Allen-Baume VL, Kad NM, Mason JM, et al
    Intracellular screening of a peptide library to derive a potent peptide inhibitor of alpha-synuclein aggregation.
    J Biol Chem. 2015;290:7426-35.
    PubMed     Text format     Abstract available


  25. SASAZAWA Y, Sato N, Umezawa K, Simizu S, et al
    Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy.
    J Biol Chem. 2015;290:6168-78.
    PubMed     Text format     Abstract available


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