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  Parkinson's Disease

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Articles published in Proc Natl Acad Sci U S A

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Single Articles


    February 2024
  1. RILEY MJ, Mitchell CC, Ernst SE, Taylor EB, et al
    A model for stimulation of enzyme activity by a competitive inhibitor based on the interaction of terazosin and phosphoglycerate kinase 1.
    Proc Natl Acad Sci U S A. 2024;121:e2318956121.
    PubMed     Abstract available


  2. RONTGEN A, Toprakcioglu Z, Tomkins JE, Vendruscolo M, et al
    Modulation of alpha-synuclein in vitro aggregation kinetics by its alternative splice isoforms.
    Proc Natl Acad Sci U S A. 2024;121:e2313465121.
    PubMed     Abstract available


    January 2024
  3. GILBOA T, Swank Z, Thakur R, Gould RA, et al
    Toward the quantification of alpha-synuclein aggregates with digital seed amplification assays.
    Proc Natl Acad Sci U S A. 2024;121:e2312031121.
    PubMed     Abstract available


  4. AUBREY LD, Ninkina N, Ulamec SM, Abramycheva NY, et al
    Substitution of Met-38 to Ile in gamma-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid.
    Proc Natl Acad Sci U S A. 2024;121:e2309700120.
    PubMed     Abstract available


  5. TONG Y, Zhang P, Yang X, Liu X, et al
    Decreasing the intrinsically disordered protein alpha-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera.
    Proc Natl Acad Sci U S A. 2024;121:e2306682120.
    PubMed     Abstract available


  6. KAKUDA K, Ikenaka K, Kuma A, Doi J, et al
    Lysophagy protects against propagation of alpha-synuclein aggregation through ruptured lysosomal vesicles.
    Proc Natl Acad Sci U S A. 2024;121:e2312306120.
    PubMed     Abstract available


    December 2023
  7. QI C, Verheijen BM, Kokubo Y, Shi Y, et al
    Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
    Proc Natl Acad Sci U S A. 2023;120:e2306767120.
    PubMed     Abstract available


    November 2023
  8. BODILY TA, Ramanathan A, Wei S, Karkisaval A, et al
    In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected by DNA aptamer-attached portable graphene biosensor.
    Proc Natl Acad Sci U S A. 2023;120:e2311565120.
    PubMed     Abstract available


    October 2023
  9. YESHAW WM, Adhikari A, Chiang CY, Dhekne HS, et al
    Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.
    Proc Natl Acad Sci U S A. 2023;120:e2315171120.
    PubMed     Abstract available


  10. LAI Y, Zhao C, Tian Z, Wang C, et al
    Neutral lysophosphatidylcholine mediates alpha-synuclein-induced synaptic vesicle clustering.
    Proc Natl Acad Sci U S A. 2023;120:e2310174120.
    PubMed     Abstract available


  11. WANG X, Espadas J, Wu Y, Cai S, et al
    Membrane remodeling properties of the Parkinson's disease protein LRRK2.
    Proc Natl Acad Sci U S A. 2023;120:e2309698120.
    PubMed     Abstract available


    September 2023
  12. KIM DY, Shin JY, Lee JE, Kim HN, et al
    A selective ER-phagy exerts neuroprotective effects via modulation of alpha-synuclein clearance in parkinsonian models.
    Proc Natl Acad Sci U S A. 2023;120:e2221929120.
    PubMed     Abstract available


  13. LE GUEN Y, Luo G, Ambati A, Damotte V, et al
    Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes.
    Proc Natl Acad Sci U S A. 2023;120:e2302720120.
    PubMed     Abstract available


    August 2023
  14. YADAVALLI N, Ferguson SM
    LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition.
    Proc Natl Acad Sci U S A. 2023;120:e2303789120.
    PubMed     Abstract available


    July 2023
  15. ZHANG S, Yi S, Wang L, Li S, et al
    Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia.
    Proc Natl Acad Sci U S A. 2023;120:e2301002120.
    PubMed     Abstract available


    June 2023
  16. MATSUI H, Ito S, Matsui H, Ito J, et al
    Phosphorylation of alpha-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2214652120.
    PubMed     Abstract available


    April 2023
  17. PENG JY, Qi ZX, Yan Q, Fan XJ, et al
    Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus-thalamus circuitry.
    Proc Natl Acad Sci U S A. 2023;120:e2216247120.
    PubMed     Abstract available


  18. SCHWARZ TC, Beier A, Ledolter K, Gossenreiter T, et al
    High-resolution structural information of membrane-bound alpha-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599.
    Proc Natl Acad Sci U S A. 2023;120:e2201910120.
    PubMed     Abstract available


    March 2023
  19. CHEUNG THC, Ding Y, Zhuang X, Kang UJ, et al
    Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment.
    Proc Natl Acad Sci U S A. 2023;120:e2213093120.
    PubMed     Abstract available


    February 2023
  20. DADA ST, Hardenberg MC, Toprakcioglu Z, Mrugalla LK, et al
    Spontaneous nucleation and fast aggregate-dependent proliferation of alpha-synuclein aggregates within liquid condensates at neutral pH.
    Proc Natl Acad Sci U S A. 2023;120:e2208792120.
    PubMed     Abstract available


  21. LIU YJ, Ding Y, Yin YQ, Xiao H, et al
    Cspg4(high) microglia contribute to microgliosis during neurodegeneration.
    Proc Natl Acad Sci U S A. 2023;120:e2210643120.
    PubMed     Abstract available


  22. NOURSE JB JR, Russell SN, Moniz NA, Peter K, et al
    Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models.
    Proc Natl Acad Sci U S A. 2023;120:e2210712120.
    PubMed     Abstract available


  23. MURRAY KA, Hu CJ, Pan H, Lu J, et al
    Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.
    Proc Natl Acad Sci U S A. 2023;120:e2217835120.
    PubMed     Abstract available


    January 2023
  24. ZHAO X, Lin Y, Liou B, Fu W, et al
    PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases.
    Proc Natl Acad Sci U S A. 2023;120:e2210442120.
    PubMed     Abstract available


    December 2022
  25. SHEA D, Colasurdo E, Smith A, Paschall C, et al
    SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers.
    Proc Natl Acad Sci U S A. 2022;119:e2213157119.
    PubMed     Abstract available


    October 2022
  26. WANG X, Rimal S, Tantray I, Geng J, et al
    Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1.
    Proc Natl Acad Sci U S A. 2022;119:e2202322119.
    PubMed     Abstract available


  27. MORTEN MJ, Sirvio L, Rupawala H, Mee Hayes E, et al
    Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies.
    Proc Natl Acad Sci U S A. 2022;119:e2205591119.
    PubMed     Abstract available


    September 2022
  28. KAM TI, Park H, Chou SC, Van Vranken JG, et al
    Amelioration of pathologic alpha-synuclein-induced Parkinson's disease by irisin.
    Proc Natl Acad Sci U S A. 2022;119:e2204835119.
    PubMed     Abstract available


    August 2022
  29. SCHERER M, Steiner LA, Kalia SK, Hodaie M, et al
    Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson's disease and essential tremor.
    Proc Natl Acad Sci U S A. 2022;119:e2205881119.
    PubMed     Abstract available


  30. MURRAY KA, Hu CJ, Griner SL, Pan H, et al
    De novo designed protein inhibitors of amyloid aggregation and seeding.
    Proc Natl Acad Sci U S A. 2022;119:e2206240119.
    PubMed     Abstract available


    July 2022
  31. PARMAR M
    Targets for astrocyte-based treatments of Parkinson's disease (PD).
    Proc Natl Acad Sci U S A. 2022;119:e2208876119.
    PubMed    


  32. YANG Y, Song JJ, Choi YR, Kim SH, et al
    Therapeutic functions of astrocytes to treat alpha-synuclein pathology in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2110746119.
    PubMed     Abstract available


  33. DEEN MC, Zhu Y, Gros C, Na N, et al
    A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells.
    Proc Natl Acad Sci U S A. 2022;119:e2200553119.
    PubMed     Abstract available


    June 2022
  34. ENINGER T, Muller SA, Bacioglu M, Schweighauser M, et al
    Signatures of glial activity can be detected in the CSF proteome.
    Proc Natl Acad Sci U S A. 2022;119:e2119804119.
    PubMed     Abstract available


    May 2022
  35. ADAM EM, Brown EN, Kopell N, McCarthy MM, et al
    Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks.
    Proc Natl Acad Sci U S A. 2022;119:e2120808119.
    PubMed     Abstract available


    April 2022
  36. STANDAERT DG, Childers GM
    Alpha-synuclein-mediated DNA damage, STING activation, and neuroinflammation in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2204058119.
    PubMed    


  37. HINKLE JT, Patel J, Panicker N, Karuppagounder SS, et al
    STING mediates neurodegeneration and neuroinflammation in nigrostriatal alpha-synucleinopathy.
    Proc Natl Acad Sci U S A. 2022;119:e2118819119.
    PubMed     Abstract available


    March 2022
  38. AZEVEDO C, Teku G, Pomeshchik Y, Reyes JF, et al
    Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.
    Proc Natl Acad Sci U S A. 2022;119:e2111405119.
    PubMed     Abstract available


  39. KIM J, Gao Y, Zhao Z, Rodrigues D, et al
    A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  40. SUN CP, Zhou JJ, Yu ZL, Huo XK, et al
    Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  41. SINGH RK, Soliman A, Guaitoli G, Stormer E, et al
    Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    February 2022
  42. AYERS JI, Lee J, Monteiro O, Woerman AL, et al
    Different alpha-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  43. KILLINGER BA, Marshall LL, Chatterjee D, Chu Y, et al
    In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    January 2022
  44. HEREMANS IP, Caligiore F, Gerin I, Bury M, et al
    Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    December 2021

  45. Correction to Supporting Information for Ahuja et al., Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


    November 2021
  46. AHUJA M, Ammal Kaidery N, Attucks OC, McDade E, et al
    Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    October 2021
  47. FOUGERE M, van der Zouwen CI, Boutin J, Neszvecsko K, et al
    Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  48. VOS M, Dulovic-Mahlow M, Mandik F, Frese L, et al
    Ceramide accumulation induces mitophagy and impairs beta-oxidation in PINK1 deficiency.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    September 2021
  49. SCHEIDT T, Carozza JA, Kolbe CC, Aprile FA, et al
    The binding of the small heat-shock protein alphaB-crystallin to fibrils of alpha-synuclein is driven by entropic forces.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  50. FRANCO A, Gracia P, Colom A, Camino JD, et al
    All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of alpha-synuclein toxic species.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    August 2021
  51. TOYAMA Y, Harkness RW, Kay LE
    Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    June 2021
  52. ZHANG S, Liu YQ, Jia C, Lim YJ, et al
    Mechanistic basis for receptor-mediated pathological alpha-synuclein fibril cell-to-cell transmission in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  53. TISZA MJ, Buck CB
    A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    May 2021
  54. LONG H, Zheng W, Liu Y, Sun Y, et al
    Wild-type alpha-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  55. YANG X, Wang B, Hoop CL, Williams JK, et al
    NMR unveils an N-terminal interaction interface on acetylated-alpha-synuclein monomers for recruitment to fibrils.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    April 2021
  56. TRUDLER D, Nazor KL, Eisele YS, Grabauskas T, et al
    Soluble alpha-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    March 2021
  57. SOBU Y, Wawro PS, Dhekne HS, Yeshaw WM, et al
    Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    January 2021
  58. REBELO D, Oliveira F, Abrunhosa A, Januario C, et al
    A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  59. APICCO DJ, Shlevkov E, Nezich CL, Tran DT, et al
    The Parkinson's disease-associated gene ITPKB protects against alpha-synuclein aggregation by regulating ER-to-mitochondria calcium release.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    December 2020
  60. VRIJSEN S, Besora-Casals L, van Veen S, Zielich J, et al
    ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
    Proc Natl Acad Sci U S A. 2020;117:31198-31207.
    PubMed     Abstract available


    October 2020
  61. BREKK OR, Honey JR, Lee S, Hallett PJ, et al
    Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance.
    Proc Natl Acad Sci U S A. 2020 Oct 15. pii: 2003021117.
    PubMed     Abstract available


  62. MOR DE, Sohrabi S, Kaletsky R, Keyes W, et al
    Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria.
    Proc Natl Acad Sci U S A. 2020 Oct 6. pii: 2009838117.
    PubMed     Abstract available


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