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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 44 articles:
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    May 2018
  1. KIM KS, Marcogliese PC, Yang J, Callaghan SM, et al
    Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 May 14. pii: 1718946115.
    PubMed     Text format     Abstract available


  2. NGUYEN M, Krainc D
    LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 May 7. pii: 1717590115.
    PubMed     Text format     Abstract available


  3. REN Q, Ma M, Yang J, Nonaka R, et al
    Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 May 7. pii: 1802179115.
    PubMed     Text format     Abstract available


    March 2018
  4. KUMAR J, Erana H, Lopez-Martinez E, Claes N, et al
    Detection of amyloid fibrils in Parkinson's disease using plasmonic chirality.
    Proc Natl Acad Sci U S A. 2018 Mar 12. pii: 1721690115.
    PubMed     Text format     Abstract available


    February 2018
  5. GRASSI D, Howard S, Zhou M, Diaz-Perez N, et al
    Identification of a highly neurotoxic alpha-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2018 Feb 27. pii: 1713849115.
    PubMed     Text format     Abstract available


    December 2017
  6. WOERMAN AL, Kazmi SA, Patel S, Aoyagi A, et al
    Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.
    Proc Natl Acad Sci U S A. 2017 Dec 26. pii: 1719369115.
    PubMed     Text format     Abstract available


  7. BRAGG DC, Mangkalaphiban K, Vaine CA, Kulkarni NJ, et al
    Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1.
    Proc Natl Acad Sci U S A. 2017 Dec 11. pii: 1712526114.
    PubMed     Text format     Abstract available


    September 2017
  8. KANG SS, Zhang Z, Liu X, Manfredsson FP, et al
    TrkB neurotrophic activities are blocked by alpha-synuclein, triggering dopaminergic cell death in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Sep 18. pii: 201713969.
    PubMed     Text format     Abstract available


  9. THAKUR P, Breger LS, Lundblad M, Wan OW, et al
    Modeling Parkinson's disease pathology by combination of fibril seeds and alpha-synuclein overexpression in the rat brain.
    Proc Natl Acad Sci U S A. 2017 Sep 12. pii: 201710442.
    PubMed     Text format     Abstract available


    June 2017
  10. TURRIANI E, Lazaro DF, Ryazanov S, Leonov A, et al
    Treatment with diphenyl-pyrazole compound anle138b/c reveals that alpha-synuclein protects melanoma cells from autophagic cell death.
    Proc Natl Acad Sci U S A. 2017 Jun 5. pii: 201700200.
    PubMed     Text format     Abstract available


    April 2017
  11. KOUROUPI G, Taoufik E, Vlachos IS, Tsioras K, et al
    Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Apr 17. pii: 201617259.
    PubMed     Text format     Abstract available



  12. Editorial Expression of Concern: Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.
    Proc Natl Acad Sci U S A. 2017 Apr 3. pii: 201704295.
    PubMed     Text format    


    March 2017
  13. KIM KS
    Toward neuroprotective treatments of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Mar 30. pii: 201703362.
    PubMed     Text format    


  14. SPATHIS AD, Asvos X, Ziavra D, Karampelas T, et al
    Nurr1:RXRalpha heterodimer activation as monotherapy for Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Mar 27. pii: 201616874.
    PubMed     Text format     Abstract available


  15. MOLLENHAUER B, Weintraub D
    The depressed brain in Parkinson's disease: Implications for an inflammatory biomarker.
    Proc Natl Acad Sci U S A. 2017 Mar 10. pii: 201700737.
    PubMed     Text format    


    February 2017
  16. DUNN AR, Stout KA, Ozawa M, Lohr KM, et al
    Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.
    Proc Natl Acad Sci U S A. 2017 Feb 28. pii: 201616892.
    PubMed     Text format     Abstract available


    January 2017
  17. GREEN H, Zhang X, Tiklova K, Volakakis N, et al
    Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Jan 30. pii: 201621218.
    PubMed     Text format     Abstract available


  18. PARK Y, Hoang QQ
    Combating Parkinson's disease-associated toxicity by modulating proteostasis.
    Proc Natl Acad Sci U S A. 2017 Jan 17. pii: 201620082.
    PubMed     Text format    


    October 2016
  19. HORVATH I, Wittung-Stafshede P
    Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2016 Oct 17. pii: 201610371.
    PubMed     Text format     Abstract available


    August 2016
  20. FLAGMEIER P, Meisl G, Vendruscolo M, Knowles TP, et al
    Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of alpha-synuclein aggregation.
    Proc Natl Acad Sci U S A. 2016 Aug 29. pii: 201604645.
    PubMed     Text format     Abstract available


  21. SINGH A, Mewes K, Gross RE, DeLong MR, et al
    Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2016 Aug 8. pii: 201606792.
    PubMed     Text format     Abstract available


  22. WANG W, Nguyen LT, Burlak C, Chegini F, et al
    Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein alpha-synuclein.
    Proc Natl Acad Sci U S A. 2016 Aug 1. pii: 201610099.
    PubMed     Text format     Abstract available


    July 2016
  23. COOKSON MR
    Structure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson's disease.
    Proc Natl Acad Sci U S A. 2016;113:8346-8.
    PubMed     Text format    


    June 2016
  24. GUAITOLI G, Raimondi F, Gilsbach BK, Gomez-Llorente Y, et al
    Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
    Proc Natl Acad Sci U S A. 2016 Jun 29. pii: 201523708.
    PubMed     Text format     Abstract available


    May 2016
  25. KORDOWER JH, Olanow CW
    Fetal grafts for Parkinson's disease: Decades in the making.
    Proc Natl Acad Sci U S A. 2016 May 31. pii: 201606342.
    PubMed     Text format    


  26. LI W, Englund E, Widner H, Mattsson B, et al
    Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain.
    Proc Natl Acad Sci U S A. 2016 May 2. pii: 201605245.
    PubMed     Text format     Abstract available


    April 2016
  27. PINOTSI D, Michel CH, Buell AK, Laine RF, et al
    Nanoscopic insights into seeding mechanisms and toxicity of alpha-synuclein species in neurons.
    Proc Natl Acad Sci U S A. 2016;113:3815-9.
    PubMed     Text format     Abstract available


    March 2016
  28. DODSON PD, Dreyer JK, Jennings KA, Syed EC, et al
    Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.
    Proc Natl Acad Sci U S A. 2016 Mar 21. pii: 201515941.
    PubMed     Text format     Abstract available


    February 2016
  29. MAZZULLI JR, Zunke F, Isacson O, Studer L, et al
    alpha-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.
    Proc Natl Acad Sci U S A. 2016;113:1931-6.
    PubMed     Text format     Abstract available


  30. FARES MB, Maco B, Oueslati A, Rockenstein E, et al
    Induction of de novo alpha-synuclein fibrillization in a neuronal model for Parkinson's disease.
    Proc Natl Acad Sci U S A. 2016 Feb 2. pii: 201512876.
    PubMed     Text format     Abstract available


    January 2016
  31. MARONGIU R, Arango-Lievano M, Francardo V, Morgenstern P, et al
    Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice.
    Proc Natl Acad Sci U S A. 2016 Jan 19. pii: 201524387.
    PubMed     Text format     Abstract available


  32. SCHINTU N, Zhang X, Alvarsson A, Marongiu R, et al
    p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism.
    Proc Natl Acad Sci U S A. 2016 Jan 19. pii: 201524303.
    PubMed     Text format     Abstract available


  33. KISHIDA KT, Saez I, Lohrenz T, Witcher MR, et al
    Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward.
    Proc Natl Acad Sci U S A. 2016;113:200-5.
    PubMed     Text format     Abstract available


    September 2015
  34. STEVENS DA, Lee Y, Kang HC, Lee BD, et al
    Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.
    Proc Natl Acad Sci U S A. 2015;112:11696-701.
    PubMed     Text format     Abstract available


    August 2015
  35. PRUSINER SB, Woerman AL, Mordes DA, Watts JC, et al
    Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism.
    Proc Natl Acad Sci U S A. 2015 Aug 31. pii: 201514475.
    PubMed     Text format     Abstract available


    July 2015
  36. LIU G, Bao X, Wang R
    Expression quantitative trait loci regulate HNF4A and PTBP1 expression in human brains.
    Proc Natl Acad Sci U S A. 2015;112:E3975.
    PubMed     Text format    


  37. SANTIAGO JA, Potashkin JA
    Reply to Liu et al.: HNF4A and PTBP1 expression in the brain of neurodegenerative disease patients.
    Proc Natl Acad Sci U S A. 2015;112:E3976.
    PubMed     Text format    


  38. MCGLINCHEY RP, Lee JC
    Cysteine cathepsins are essential in lysosomal degradation of alpha-synuclein.
    Proc Natl Acad Sci U S A. 2015;112:9322-7.
    PubMed     Text format     Abstract available


  39. HOLEMANS T, Sorensen DM, van Veen S, Martin S, et al
    A lipid switch unlocks Parkinson's disease-associated ATP13A2.
    Proc Natl Acad Sci U S A. 2015 Jul 1. pii: 201508220.
    PubMed     Text format     Abstract available


    June 2015
  40. KIM CH, Han BS, Moon J, Kim DJ, et al
    Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2015 Jun 29. pii: 201509742.
    PubMed     Text format     Abstract available


  41. TOKER L, Pavlidis P
    Metaanalysis of flawed expression profiling data leading to erroneous Parkinson's biomarker identification.
    Proc Natl Acad Sci U S A. 2015 Jun 23. pii: 201507563.
    PubMed     Text format    


  42. SANTIAGO JA, Potashkin JA
    Reply to Toker and Pavlidis: Blood biomarkers for Parkinson's disease.
    Proc Natl Acad Sci U S A. 2015 Jun 23. pii: 201508415.
    PubMed     Text format    


    May 2015
  43. UNAL GULSUNER H, Gulsuner S, Mercan FN, Onat OE, et al
    Reply to Tzoulis et al.: Genetic and clinical heterogeneity of essential tremor.
    Proc Natl Acad Sci U S A. 2015;112:E2269.
    PubMed     Text format    


    April 2015
  44. BYE CR, Jonsson ME, Bjorklund A, Parish CL, et al
    Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors.
    Proc Natl Acad Sci U S A. 2015;112:E1946-55.
    PubMed     Text format     Abstract available


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