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Articles published in Proc Natl Acad Sci U S A

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    April 2017
  1. KOUROUPI G, Taoufik E, Vlachos IS, Tsioras K, et al
    Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Apr 17. pii: 201617259.
    PubMed     Text format     Abstract available



  2. Editorial Expression of Concern: Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.
    Proc Natl Acad Sci U S A. 2017 Apr 3. pii: 201704295.
    PubMed     Text format    


    March 2017
  3. KIM KS
    Toward neuroprotective treatments of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Mar 30. pii: 201703362.
    PubMed     Text format    


  4. SPATHIS AD, Asvos X, Ziavra D, Karampelas T, et al
    Nurr1:RXRalpha heterodimer activation as monotherapy for Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Mar 27. pii: 201616874.
    PubMed     Text format     Abstract available


  5. MOLLENHAUER B, Weintraub D
    The depressed brain in Parkinson's disease: Implications for an inflammatory biomarker.
    Proc Natl Acad Sci U S A. 2017 Mar 10. pii: 201700737.
    PubMed     Text format    


    February 2017
  6. DUNN AR, Stout KA, Ozawa M, Lohr KM, et al
    Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.
    Proc Natl Acad Sci U S A. 2017 Feb 28. pii: 201616892.
    PubMed     Text format     Abstract available


    January 2017
  7. GREEN H, Zhang X, Tiklova K, Volakakis N, et al
    Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2017 Jan 30. pii: 201621218.
    PubMed     Text format     Abstract available


  8. PARK Y, Hoang QQ
    Combating Parkinson's disease-associated toxicity by modulating proteostasis.
    Proc Natl Acad Sci U S A. 2017 Jan 17. pii: 201620082.
    PubMed     Text format    


    October 2016
  9. HORVATH I, Wittung-Stafshede P
    Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2016 Oct 17. pii: 201610371.
    PubMed     Text format     Abstract available


    August 2016
  10. FLAGMEIER P, Meisl G, Vendruscolo M, Knowles TP, et al
    Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of alpha-synuclein aggregation.
    Proc Natl Acad Sci U S A. 2016 Aug 29. pii: 201604645.
    PubMed     Text format     Abstract available


  11. SINGH A, Mewes K, Gross RE, DeLong MR, et al
    Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2016 Aug 8. pii: 201606792.
    PubMed     Text format     Abstract available


  12. WANG W, Nguyen LT, Burlak C, Chegini F, et al
    Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein alpha-synuclein.
    Proc Natl Acad Sci U S A. 2016 Aug 1. pii: 201610099.
    PubMed     Text format     Abstract available


    July 2016
  13. COOKSON MR
    Structure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson's disease.
    Proc Natl Acad Sci U S A. 2016;113:8346-8.
    PubMed     Text format    


    June 2016
  14. GUAITOLI G, Raimondi F, Gilsbach BK, Gomez-Llorente Y, et al
    Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
    Proc Natl Acad Sci U S A. 2016 Jun 29. pii: 201523708.
    PubMed     Text format     Abstract available


    May 2016
  15. KORDOWER JH, Olanow CW
    Fetal grafts for Parkinson's disease: Decades in the making.
    Proc Natl Acad Sci U S A. 2016 May 31. pii: 201606342.
    PubMed     Text format    


  16. LI W, Englund E, Widner H, Mattsson B, et al
    Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain.
    Proc Natl Acad Sci U S A. 2016 May 2. pii: 201605245.
    PubMed     Text format     Abstract available


    April 2016
  17. PINOTSI D, Michel CH, Buell AK, Laine RF, et al
    Nanoscopic insights into seeding mechanisms and toxicity of alpha-synuclein species in neurons.
    Proc Natl Acad Sci U S A. 2016;113:3815-9.
    PubMed     Text format     Abstract available


    March 2016
  18. DODSON PD, Dreyer JK, Jennings KA, Syed EC, et al
    Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.
    Proc Natl Acad Sci U S A. 2016 Mar 21. pii: 201515941.
    PubMed     Text format     Abstract available


    February 2016
  19. MAZZULLI JR, Zunke F, Isacson O, Studer L, et al
    alpha-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.
    Proc Natl Acad Sci U S A. 2016;113:1931-6.
    PubMed     Text format     Abstract available


  20. FARES MB, Maco B, Oueslati A, Rockenstein E, et al
    Induction of de novo alpha-synuclein fibrillization in a neuronal model for Parkinson's disease.
    Proc Natl Acad Sci U S A. 2016 Feb 2. pii: 201512876.
    PubMed     Text format     Abstract available


    January 2016
  21. MARONGIU R, Arango-Lievano M, Francardo V, Morgenstern P, et al
    Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice.
    Proc Natl Acad Sci U S A. 2016 Jan 19. pii: 201524387.
    PubMed     Text format     Abstract available


  22. SCHINTU N, Zhang X, Alvarsson A, Marongiu R, et al
    p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism.
    Proc Natl Acad Sci U S A. 2016 Jan 19. pii: 201524303.
    PubMed     Text format     Abstract available


  23. KISHIDA KT, Saez I, Lohrenz T, Witcher MR, et al
    Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward.
    Proc Natl Acad Sci U S A. 2016;113:200-5.
    PubMed     Text format     Abstract available


    September 2015
  24. STEVENS DA, Lee Y, Kang HC, Lee BD, et al
    Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.
    Proc Natl Acad Sci U S A. 2015;112:11696-701.
    PubMed     Text format     Abstract available


    August 2015
  25. PRUSINER SB, Woerman AL, Mordes DA, Watts JC, et al
    Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism.
    Proc Natl Acad Sci U S A. 2015 Aug 31. pii: 201514475.
    PubMed     Text format     Abstract available


    July 2015
  26. LIU G, Bao X, Wang R
    Expression quantitative trait loci regulate HNF4A and PTBP1 expression in human brains.
    Proc Natl Acad Sci U S A. 2015;112:E3975.
    PubMed     Text format    


  27. SANTIAGO JA, Potashkin JA
    Reply to Liu et al.: HNF4A and PTBP1 expression in the brain of neurodegenerative disease patients.
    Proc Natl Acad Sci U S A. 2015;112:E3976.
    PubMed     Text format    


  28. MCGLINCHEY RP, Lee JC
    Cysteine cathepsins are essential in lysosomal degradation of alpha-synuclein.
    Proc Natl Acad Sci U S A. 2015;112:9322-7.
    PubMed     Text format     Abstract available


  29. HOLEMANS T, Sorensen DM, van Veen S, Martin S, et al
    A lipid switch unlocks Parkinson's disease-associated ATP13A2.
    Proc Natl Acad Sci U S A. 2015 Jul 1. pii: 201508220.
    PubMed     Text format     Abstract available


    June 2015
  30. KIM CH, Han BS, Moon J, Kim DJ, et al
    Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2015 Jun 29. pii: 201509742.
    PubMed     Text format     Abstract available


  31. TOKER L, Pavlidis P
    Metaanalysis of flawed expression profiling data leading to erroneous Parkinson's biomarker identification.
    Proc Natl Acad Sci U S A. 2015 Jun 23. pii: 201507563.
    PubMed     Text format    


  32. SANTIAGO JA, Potashkin JA
    Reply to Toker and Pavlidis: Blood biomarkers for Parkinson's disease.
    Proc Natl Acad Sci U S A. 2015 Jun 23. pii: 201508415.
    PubMed     Text format    


    May 2015
  33. UNAL GULSUNER H, Gulsuner S, Mercan FN, Onat OE, et al
    Reply to Tzoulis et al.: Genetic and clinical heterogeneity of essential tremor.
    Proc Natl Acad Sci U S A. 2015;112:E2269.
    PubMed     Text format    


    April 2015
  34. URS NM, Bido S, Peterson SM, Daigle TL, et al
    Targeting beta-arrestin2 in the treatment of l-DOPA-induced dyskinesia in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2015 Apr 27. pii: 201502740.
    PubMed     Text format     Abstract available


  35. BYE CR, Jonsson ME, Bjorklund A, Parish CL, et al
    Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors.
    Proc Natl Acad Sci U S A. 2015;112:E1946-55.
    PubMed     Text format     Abstract available


    March 2015
  36. TZOULIS C, Zayats T, Knappskog PM, Muller B, et al
    HTRA2 p.G399S in Parkinson disease, essential tremor, and tremulous cervical dystonia.
    Proc Natl Acad Sci U S A. 2015 Mar 30. pii: 201503105.
    PubMed     Text format    


    February 2015
  37. SPETSIERIS PG, Ko JH, Tang CC, Nazem A, et al
    Metabolic resting-state brain networks in health and disease.
    Proc Natl Acad Sci U S A. 2015;112:2563-8.
    PubMed     Text format     Abstract available


  38. SANTIAGO JA, Potashkin JA
    Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease.
    Proc Natl Acad Sci U S A. 2015 Feb 2. pii: 201423573.
    PubMed     Text format     Abstract available


    January 2015
  39. SANTANIELLO S, McCarthy MM, Montgomery EB Jr, Gale JT, et al
    Therapeutic mechanisms of high-frequency stimulation in Parkinson's disease and neural restoration via loop-based reinforcement.
    Proc Natl Acad Sci U S A. 2015 Jan 26. pii: 201406549.
    PubMed     Text format     Abstract available


  40. KURUP PK, Xu J, Videira RA, Ononenyi C, et al
    STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2015 Jan 12. pii: 201417423.
    PubMed     Text format     Abstract available


    December 2014
  41. OLANOW CW, Obeso J
    Profile of Mahlon DeLong and Alim Benabid, 2014 Lasker-DeBakey Medical Research awardees.
    Proc Natl Acad Sci U S A. 2014;111:17693-5.
    PubMed     Text format    


    November 2014
  42. UNAL GULSUNER H, Gulsuner S, Mercan FN, Onat OE, et al
    Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease.
    Proc Natl Acad Sci U S A. 2014 Nov 24. pii: 201419581.
    PubMed     Text format     Abstract available


    October 2014
  43. WONG YC, Holzbaur EL
    Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation.
    Proc Natl Acad Sci U S A. 2014;111:E4439-48.
    PubMed     Text format     Abstract available


    August 2014
  44. SMALL SA
    Pharmacological chaperones in the age of proteomic pathology.
    Proc Natl Acad Sci U S A. 2014;111:12274-5.
    PubMed     Text format    


  45. CARAVEO G, Auluck PK, Whitesell L, Chung CY, et al
    Calcineurin determines toxic versus beneficial responses to alpha-synuclein.
    Proc Natl Acad Sci U S A. 2014;111:E3544-52.
    PubMed     Text format     Abstract available


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