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The Medical Article of the Year 2008


  Rheumatoid Arthritis

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Articles published in Arthritis Res Ther

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    June 2008
  1. ALTEN R , Gram H, Joosten LA, van den Berg WB, et al
    The human anti-interleukin-1b monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof of concept study in rheumatoid arthritis patients.
    Arthritis Res Ther. 2008;10:R67.
    PubMed     Related articles    Abstract available


  2. GOLDSTEIN RS
    High mobility group box-1 protein as a tumor necrosis factor-independent therapeutic target in rheumatoid arthritis.
    Arthritis Res Ther. 2008;10:111.
    PubMed     Related articles    Abstract available


    May 2008
  3. SMOLEN JS , Aletaha D, Grisar J, Redlich K, et al
    The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?
    Arthritis Res Ther. 2008;10:208.
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  4. STAVROPOULOS-KALINOGLOU A , Metsios GS, Panoulas VF, Douglas KM, et al
    Cigarette smoking associates with body weight and muscle mass of patients with rheumatoid arthritis: a cross-sectional, observational study.
    Arthritis Res Ther. 2008;10:R59.
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  5. LOVE T , Solomon DH
    The relationship between cancer and rheumatoid arthritis: still a large research agenda.
    Arthritis Res Ther. 2008;10:109.
    PubMed     Related articles    Abstract available


  6. COSTENBADER KH , Chang SC, De Vivo I, Plenge R, et al
    PTPN22, PADI-4 and CTLA-4 genetic polymorphisms and risk of rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking.
    Arthritis Res Ther. 2008;10:R52.
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  7. KOCZAN D , Drynda S, Hecker M, Drynda A, et al
    Molecular discrimination of responders and non-responders to anti-TNF-alpha therapy in rheumatoid arthritis by etanercept.
    Arthritis Res Ther. 2008;10:R50.
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    April 2008
  8. SMITTEN AL , Simon TA, Hochberg MC, Suissa S, et al
    A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis.
    Arthritis Res Ther. 2008;10:R45.
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  9. RICHARDSON D , Pearson RG, Kurian N, Latif L, et al
    Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteo- and rheumatoid arthritis.
    Arthritis Res Ther. 2008;10:R43.
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    March 2008
  10. VAN DER HELM-VAN MIL AH , Huizinga TW
    Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets.
    Arthritis Res Ther. 2008;10:205.
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  11. ELKAN AC , Sjoberg B, Kolsrud B, Ringertz B, et al
    Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study.
    Arthritis Res Ther. 2008;10:R34.
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  12. SUNDBERG E , Grundtman C, Af Klint E, Lindberg J, et al
    Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients - a prospective clinical study.
    Arthritis Res Ther. 2008;10:R33.
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  13. ANDERSSON AK , Li C, Brennan FM
    Recent developments in the immunobiology of rheumatoid arthritis.
    Arthritis Res Ther. 2008;10:204.
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  14. DOLMAN KM , Brouwer N, Frakking FN, Flato B, et al
    Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study.
    Arthritis Res Ther. 2008;10:R32.
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  15. NARANJO A , Sokka T, Descalzo MA, Calvo-Alen J, et al
    Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study.
    Arthritis Res Ther. 2008;10:R30.
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  16. SYVERSEN SW , Goll GL, Haavardsholm EA, Boyesen P, et al
    A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients.
    Arthritis Res Ther. 2008;10:R28.
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    February 2008
  17. BARNETCHE T , Constantin A, Cantagrel A, Cambon-Thomsen A, et al
    New classification of HLA-DRB1 alleles in Rheumatoid Arthritis susceptibility: a combined analysis of worldwide samples.
    Arthritis Res Ther. 2008;10:R26.
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  18. MOLLER DOHN U , Ejbjerg BJ, Hasselquist M, Narvestad E, et al
    Detection of Bone Erosions in Rheumatoid Arthritis Wrist Joints with Magnetic Resonance Imaging, Computed Tomography and Radiography.
    Arthritis Res Ther. 2008;10:R25.
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    January 2008
  19. MILICI AJ , Kudlacz EM, Audoly L, Zwillich SH, et al
    Cartilage preservation by inhibition of Janus Kinase 3 in two rodent models of rheumatoid arthritis.
    Arthritis Res Ther. 2008;10:R14.
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  20. BOTTCHER J , Pfeil A
    Diagnosis of periarticular osteoporosis in rheumatoid arthritis using digital X-ray radiogrammetry.
    Arthritis Res Ther. 2008;10:103.
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  21. ANDREAS K , Luebke C, Haeupl T, Dehne T, et al
    Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study.
    Arthritis Res Ther. 2008;10:R9.
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  22. OTERO M , Goldring MB
    Correction: Cells of the synovium in rheumatoid arthritis. Chondrocytes.
    Arthritis Res Ther. 2008;10:401.
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  23. VELDHUIJZEN VAN ZANTEN JJ , Kitas GD
    Inflammation, carotid intima-media thickness and atherosclerosis in rheumatoid arthritis.
    Arthritis Res Ther. 2008;10:102.
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    December 2007
  24. KINNE RW , Stuhlmuller B, Burmester GR
    Cells of the synovium in rheumatoid arthritis. Macrophages.
    Arthritis Res Ther. 2007;9:224.
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  25. MULLER-LADNER U , Ospelt C, Gay S, Distler O, et al
    Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts.
    Arthritis Res Ther. 2007;9:223.
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  26. AUDO R , Deschamps V, Hahne M, Combe B, et al
    Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts.
    Arthritis Res Ther. 2007;9:R128.
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    November 2007
  27. HANNAWI S , Haluska B, Marwick TH, Thomas R, et al
    Atherosclerotic disease is increased in recent onset rheumatoid arthritis: a critical role for inflammation.
    Arthritis Res Ther. 2007;9:R116.
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    October 2007
  28. IIKUNI N , Kobayashi S, Ikari K, Tomatsu T, et al
    ITGAV polymorphism and disease susceptibility in a Japanese rheumatoid arthritis population.
    Arthritis Res Ther. 2007;9:405.
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  29. AHNERT P , Kirsten H
    Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:108.
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  30. SHAHRARA S , Castro-Rueda HP, Haines K, Koch AE, et al
    Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues.
    Arthritis Res Ther. 2007;9:R112.
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  31. OTERO M , Goldring MB
    Cells of the synovium in rheumatoid arthritis. Chondrocytes.
    Arthritis Res Ther. 2007;9:220.
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  32. KOKKONEN H , Johansson M, Innala L, Jidell E, et al
    Correction: The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden.
    Arthritis Res Ther. 2007;9:403.
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  33. TENG YK , Verburg RR, Verpoort KK, Diepenhorst GG, et al
    Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated peptide autoantibodies: a case study.
    Arthritis Res Ther. 2007;9:R106.
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    September 2007
  34. SCIRE CA , Epis O, Codullo V, Humby F, et al
    Immuno-histological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure.
    Arthritis Res Ther. 2007;9:R101.
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  35. OLSSON LM , Lindqvist AK, Kallberg H, Padyukov L, et al
    A case-control study of Rheumatoid arthritis identifies an associated SNP in the NCF4 gene supporting a role for the NOX-complex in autoimmunity.
    Arthritis Res Ther. 2007;9:R98.
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  36. AUER J , Blaess M, Schulze-Koops H, Russwurm S, et al
    Expression and regulation of CCL18 in synovial fluid neutrophils of patients with rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:R94.
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  37. MARTIN-DONAIRE T , Losada-Fernandez I, Perez-Chacon G, Rua-Figueroa I, et al
    Association of the microsatellite in the 3'UTR of the CD154 gene with rheumatoid arthritis in females from a Spanish cohort: a case control study.
    Arthritis Res Ther. 2007;9:R89.
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  38. LUTZKY V , Hannawi S, Thomas R
    Cells of the synovium in rheumatoid arthritis. Dendritic cells.
    Arthritis Res Ther. 2007;9:219.
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  39. FASTH AE , Snir O, Johansson AA, Nordmark B, et al
    Skewed distribution of proinflammatory CD4+CD28null T cells in rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:R87.
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    August 2007
  40. VAN ROON JA
    Activating and inhibitory Fcgamma receptors in rheumatoid arthritis: from treatment to targeted therapies.
    Arthritis Res Ther. 2007;9:106.
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  41. HOFF M , Haugeberg G, Kvien TK
    Hand bone loss as outcome measure in established rheumatoid arthritis: a two-year observational study comparing cortical and total bone loss.
    Arthritis Res Ther. 2007;9:R81.
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    July 2007
  42. BLACKMAN MR , Muniyappa R, Wilson M, Moquin BE, et al
    Diurnal secretion of growth hormone, cortisol and dehydroepiandrosterone in pre- and peri-menopausal women with active rheumatoid arthritis: a pilot case control study.
    Arthritis Res Ther. 2007;9:R73.
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  43. KAPRAL T , Dernoschnig F, Machold KP, Stamm T, et al
    Remission by composite scores in rheumatoid arthritis: are ankles and feet important?
    Arthritis Res Ther. 2007;9:R72.
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  44. BOOTS AM , Hubers H, Kouwijzer M, den Hoed-van Zandbrink L, et al
    Identification of an altered peptide ligand based on the endogenously presented, rheumatoid arthritis-associated, human cartilage glycoprotein-39 (aa263-275) epitope: an MHC anchor variant peptide for immune modulation.
    Arthritis Res Ther. 2007;9:R71.
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  45. JACQ L , Garnier S, Dieude P, Michou L, et al
    The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study.
    Arthritis Res Ther. 2007;9:R63.
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  46. VAN DER HEIJDE D , Landewe R, Boonen A, Einstein SG, et al
    Expert agreement confirms that negative changes in hand and foot radiographs are a surrogate for repair in patients with rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:R62.
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    June 2007
  47. MARROTTE H , Pallot-Prades B, Grange L, Gaudin P, et al
    A one year case control study in rheumatoid arthritis patients indicates a prevention of bone mineral density loss in both responders and non responders to infliximab.
    Arthritis Res Ther. 2007;9:R61.
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  48. POHLERS D , Beyer A, Koczan D, Wilhelm T, et al
    Constitutive upregulation of the TGF-b pathway in rheumatoid arthritis synovial fibroblasts.
    Arthritis Res Ther. 2007;9:R59.
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  49. HAYNES DR
    Inflammatory cells and bone loss in rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:104.
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  50. HAMMAKER DR , Boyle DL, Inoue T, Firestein GS, et al
    Regulation of the JNK pathway by TGF-beta activated kinase 1 (TAK1) in rheumatoid arthritis synoviocytes.
    Arthritis Res Ther. 2007;9:R57.
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  51. KOKKONEN H , Johansson M, Innala L, Eriksson C, et al
    The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody positive early rheumatoid arthritis in northern Sweden.
    Arthritis Res Ther. 2007;9:R56.
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    May 2007
  52. MAGNUSSON SE , Engstrom M, Jacob U, Ulfgren AK, et al
    High synovial expression of the inhibitory FcgammaRIIb in rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:R51.
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    April 2007
  53. KIM WU , Kwok SK, Hong KH, Yoo SA, et al
    Soluble Fas ligand inhibits angiogenesis in rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:R42.
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  54. MARINOU I , Montgomery DS, Dickson MC, Binks MH, et al
    The interferon-induced helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:R40.
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  55. CARROLL L , Frazer IH, Turner M, Marwick T, et al
    The receptor for advanced glycation end products Glycine 82 Serine polymorphism and the risk of cardiovascular events in rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:R39.
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  56. FONSECA JE , Cavaleiro J, Teles J, Sousa E, et al
    Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumour necrosis factor alpha gene promoter.
    Arthritis Res Ther. 2007;9:R37.
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    March 2007
  57. POUBELLE PE , Chakravarti A, Fernandes MJ, Doiron K, et al
    Differential expression of RANK/RANK-L/OPG by synovial fluid neutrophils from patients with rheumatoid arthritis and normal human blood neutrophils.
    Arthritis Res Ther. 2007;9:R25.
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  58. MAURI C , Ehrenstein MR
    Cells of the synovium in rheumatoid arthritis. B cells.
    Arthritis Res Ther. 2007;9:205.
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  59. GOURRAUD PA , Dieude P, Boyer JF, Nogueira L, et al
    A New Classification of HLA-DRB1 Alleles Differentiates Predisposing and Protective Alleles for Autoantibody Production in Rheumatoid Arthritis.
    Arthritis Res Ther. 2007;9:R21.
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    February 2007
  60. LOURIDA ES , Georgiadis AN, Papavasiliou EC, Papathanasiou AI, et al
    Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized LDL and decreased activity of the lipoprotein-associated phospholipase A2.
    Arthritis Res Ther. 2007;9:R19.
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  61. SCHETT G
    Cells of the synovium in rheumatoid arthritis. Osteoclasts.
    Arthritis Res Ther. 2007;9:203.
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  62. LUNDY SK , Sarkar S, Tesmer LA, Fox DA, et al
    Cells of the synovium in rheumatoid arthritis. T lymphocytes.
    Arthritis Res Ther. 2007;9:202.
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  63. OCHI T , Yoshikawa H, Toyosaki-Maeda T, Lipsky PE, et al
    Mesenchymal stromal cells. Nurse-like cells reside in the synovial tissue and bone marrow in rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:201.
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  64. BENITO-GARCIA E , Feskanich D, Hu FB, Mandl LA, et al
    Protein, iron and meat consumption and risk of rheumatoid arthritis: a prospective cohort study.
    Arthritis Res Ther. 2007;9:R16.
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    January 2007
  65. LING S , Li Z, Borschukova O, Xiao L, et al
    The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti-oxidative pathway.
    Arthritis Res Ther. 2007;9:R5.
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  66. WANG D , Miller SC, Liu XM, Anderson B, et al
    Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis.
    Arthritis Res Ther. 2007;9:R2.
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  67. TYNDALL A , Walker UA, Cope A, Dazzi F, et al
    Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005.
    Arthritis Res Ther. 2007;9:301.
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  68. SCHAD SG , Kraus A, Haubitz I, Trcka J, et al
    Early onset pauciarticular arthritis is the major risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis.
    Arthritis Res Ther. 2007;9:R10.
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  69. SCHETT G
    Erosive arthritis.
    Arthritis Res Ther. 2007;9 Suppl 1:S2.
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  70. KOCH AE , Distler O
    Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis.
    Arthritis Res Ther. 2007;9 Suppl 2:S3.
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  71. WILLEKE P , Gaubitz M, Schotte H, Maaser C, et al
    Increased serum levels of macrophage migration inhibitory factor in patients with primary Sjogren's syndrome.
    Arthritis Res Ther. 2007;9:R43.
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  72. KNEDLA A , Neumann E, Muller-Ladner U
    Developments in the synovial biology field 2006.
    Arthritis Res Ther. 2007;9:209.
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  73. GILLESPIE MT
    Impact of cytokines and T lymphocytes upon osteoclast differentiation and function.
    Arthritis Res Ther. 2007;9:103.
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  74. WEILER T , Du Q, Krokhin O, Ens W, et al
    The identification and characterization of a novel protein, c19orf10, in the synovium.
    Arthritis Res Ther. 2007;9:R30.
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  75. FAIRHURST AM , Wallace PK, Jawad AS, Goulding NJ, et al
    Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species.
    Arthritis Res Ther. 2007;9:R29.
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  76. GOTTENBERG JE , Loiseau P, Azarian M, Chen C, et al
    CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjogren syndrome.
    Arthritis Res Ther. 2007;9:R24.
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  77. BOYER JF , Balard P, Authier H, Faucon B, et al
    Tumor necrosis factor alpha and adalimumab differentially regulate CD36 expression in human monocytes.
    Arthritis Res Ther. 2007;9:R22.
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  78. LESTER S , Downie-Doyle S, Rischmueller M
    CTLA4 polymorphism and primary Sjogren's syndrome.
    Arthritis Res Ther. 2007;9:401.
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  79. IKEDA K , Cox S, Emery P
    Aspects of early arthritis. Biological therapy in early arthritis--overtreatment or the way to go?
    Arthritis Res Ther. 2007;9:211.
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  80. SCATIZZI JC , Hutcheson J, Bickel E, Haines GK 3rd, et al
    Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis.
    Arthritis Res Ther. 2007;9:R49.
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  81. BAINBRIDGE J , Madden L, Essex D, Binks M, et al
    Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition.
    Arthritis Res Ther. 2007;9:R127.
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  82. VINCELETTE J , Xu Y, Zhang LN, Schaefer CJ, et al
    Gait analysis in a murine model of collagen-induced arthritis.
    Arthritis Res Ther. 2007;9:R123.
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  83. WIELL C , Szkudlarek M, Hasselquist M, Moller JM, et al
    Ultrasonography, magnetic resonance imaging, radiography, and clinical assessment of inflammatory and destructive changes in fingers and toes of patients with psoriatic arthritis.
    Arthritis Res Ther. 2007;9:R119.
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  84. WILLEKE P , Schluter B, Becker H, Schotte H, et al
    Mycophenolate sodium treatment in patients with primary Sjogren syndrome: a pilot trial.
    Arthritis Res Ther. 2007;9:R115.
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  85. SAMBROOK P
    Tumour necrosis factor blockade and the risk of osteoporosis: back to the future.
    Arthritis Res Ther. 2007;9:107.
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  86. WEISSBRICH B , Suss-Frohlich Y, Girschick HJ
    Seroprevalence of parvovirus B19 IgG in children affected by juvenile idiopathic arthritis.
    Arthritis Res Ther. 2007;9:R82.
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  87. HANSEN A , Lipsky PE, Dorner T
    B cells in Sjogren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue.
    Arthritis Res Ther. 2007;9:218.
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  88. KIM KS , Park EK, Ju SM, Jung HS, et al
    Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1beta stimulated fibroblast-like synoviocytes.
    Arthritis Res Ther. 2007;9:R80.
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  89. PALMER G , Busso N, Aurrand-Lions M, Talabot-Ayer D, et al
    Expression and function of junctional adhesion molecule-C in human and experimental arthritis.
    Arthritis Res Ther. 2007;9:R65.
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    December 2006
  90. CHUNG CP , Oeser A, Avalos I, Gebretsadik T, et al
    Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis.
    Arthritis Res Ther. 2006;8:R186.
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  91. MCQUEEN FM , Ostendorf B
    What is MRI bone oedema in rheumatoid arthritis and why does it matter?
    Arthritis Res Ther. 2006;8:222.
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    November 2006
  92. MATSUO K , Xiang Y, Nakamura H, Masuko K, et al
    Identification of Novel Citrullinated Autoantigens of Synovium in Rheumatoid Arthritis Using a Proteomic Approach.
    Arthritis Res Ther. 2006;8:R175.
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  93. KRISTENSEN LE , Saxne T, Nilsson JA, Geborek P, et al
    Impact of concomitant DMARD therapy on adherence to treatment with etanercept and infliximab in rheumatoid arthritis. Results from a six-year observational study in southern Sweden.
    Arthritis Res Ther. 2006;8:R174.
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  94. JANG J , Lim DS, Choi YE, Jeong Y, et al
    MLN51 and GM-CSF involvement in fibroblast-like synoviocytes (FLS) proliferation in the pathogenesis of rheumatoid arthritis.
    Arthritis Res Ther. 2006;8:R170.
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  95. BEECH JT , Andreakos E, Ciesielski CJ, Green P, et al
    T cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NF-kappaB: implications for rheumatoid arthritis.
    Arthritis Res Ther. 2006;8:R168.
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  96. VALLERSKOG T , Heimburger M, Gunnarsson I, Zhou W, et al
    Differential effects on BAFF and APRIL levels in rituximab treated patients with systemic lupus erythematosus and rheumatoid arthritis.
    Arthritis Res Ther. 2006;8:R167.
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    October 2006
  97. VANDER CRUYSSEN B , Durez P, Westhovens R, Vastesaeger N, et al
    Response to the commentary 'Pooled indices to measure rheumatoid arthritis activity: a good reflection of the physician's mind'
    Arthritis Res Ther. 2006;8:406.
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    September 2006
  98. JARVIS JN , Petty HR, Tang Y, Frank B, et al
    Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis.
    Arthritis Res Ther. 2006;8:R154.
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    January 2006
  99. CLELAND LG , James MJ, Proudman SM
    Fish oil: what the prescriber needs to know.
    Arthritis Res Ther. 2006;8:202.
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  100. GARCIA S , Bodano A, Gonzalez A, Forteza J, et al
    Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice.
    Arthritis Res Ther. 2006;8:R14.
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  101. COLLINS CE , Gavin AL, Migone TS, Hilbert DM, et al
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