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  Schizophrenia

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Articles published in Mol Psychiatry

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    March 2017
  1. STEULLET P, Cabungcal JH, Coyle J, Didriksen M, et al
    Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia.
    Mol Psychiatry. 2017 Mar 21. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  2. CHANG H, Xiao X, Li M
    The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions.
    Mol Psychiatry. 2017 Mar 14. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  3. PAGE SC, Hamersky GR, Gallo RA, Rannals MD, et al
    The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner.
    Mol Psychiatry. 2017 Mar 14. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  4. ROFFMAN JL, Petruzzi LJ, Tanner AS, Brown HE, et al
    Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial.
    Mol Psychiatry. 2017 Mar 14. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  5. ORHAN F, Fatouros-Bergman H, Goiny M, Malmqvist A, et al
    CSF GABA is reduced in first-episode psychosis and associates to symptom severity.
    Mol Psychiatry. 2017 Mar 14. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


    February 2017
  6. LEE PH, Baker JT, Holmes AJ, Jahanshad N, et al
    Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.
    Mol Psychiatry. 2017 Feb 21. doi: 10.1038/mp.2017.
    PubMed     Text format    


  7. COLLSTE K, Plaven-Sigray P, Fatouros-Bergman H, Victorsson P, et al
    Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28.
    Mol Psychiatry. 2017 Feb 14. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  8. LEE M, Sehatpour P, Hoptman MJ, Lakatos P, et al
    Neural mechanisms of mismatch negativity dysfunction in schizophrenia.
    Mol Psychiatry. 2017 Feb 7. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


    January 2017
  9. MITCHELL AC, Javidfar B, Pothula V, Ibi D, et al
    MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.
    Mol Psychiatry. 2017 Jan 24. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  10. ROALF DR, Nanga RP, Rupert PE, Hariharan H, et al
    Glutamate imaging (GluCEST) reveals lower brain GluCEST contrast in patients on the psychosis spectrum.
    Mol Psychiatry. 2017 Jan 24. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  11. VAUCHER J, Keating BJ, Lasserre AM, Gan W, et al
    Cannabis use and risk of schizophrenia: a Mendelian randomization study.
    Mol Psychiatry. 2017 Jan 24. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  12. NOTTER T, Coughlin JM, Gschwind T, Weber-Stadlbauer U, et al
    Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia.
    Mol Psychiatry. 2017 Jan 17. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  13. QIN XY, Wu HT, Cao C, Loh YP, et al
    A meta-analysis of peripheral blood nerve growth factor levels in patients with schizophrenia.
    Mol Psychiatry. 2017 Jan 10. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  14. ST POURCAIN B, Robinson EB, Anttila V, Sullivan BB, et al
    ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties.
    Mol Psychiatry. 2017 Jan 3. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    December 2016
  15. CLIFTON NE, Pocklington AJ, Scholz B, Rees E, et al
    Schizophrenia copy number variants and associative learning.
    Mol Psychiatry. 2016 Dec 13. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  16. YU H, Yan H, Li J, Li Z, et al
    Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population.
    Mol Psychiatry. 2016 Dec 6. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    November 2016
  17. BADER V, Trossbach SV, Prikulis I, Godsave SF, et al
    Misassembly of non-mutant full-length Disrupted-in-Schizophrenia 1 protein is induced by dopamine in vitro and in vivo.
    Mol Psychiatry. 2016;21:1487.
    PubMed     Text format    


  18. SCARR E, Udawela M, Thomas EA, Dean B, et al
    Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor.
    Mol Psychiatry. 2016 Nov 1. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    October 2016
  19. DELEVICH K, Abi-Dargham A, Hall J, Sawa A, et al
    Studying schizophrenia in the post-genomic era: perspectives from the 2016 summer Banbury Workshop at Cold Spring Harbor Laboratory.
    Mol Psychiatry. 2016 Oct 25. doi: 10.1038/mp.2016.
    PubMed     Text format    


  20. XU J, Hartley BJ, Kurup P, Phillips A, et al
    Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.
    Mol Psychiatry. 2016 Oct 18. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  21. LEE PH, Baker JT, Holmes AJ, Jahanshad N, et al
    Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.
    Mol Psychiatry. 2016 Oct 11. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  22. HASAN A, Wobrock T, Guse B, Langguth B, et al
    Structural brain changes are associated with response of negative symptoms to prefrontal repetitive transcranial magnetic stimulation in patients with schizophrenia.
    Mol Psychiatry. 2016 Oct 11. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  23. HOLMES SE, Hinz R, Drake RJ, Gregory CJ, et al
    In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study.
    Mol Psychiatry. 2016 Oct 4. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    September 2016
  24. STEDEHOUDER J, Kushner SA
    Myelination of parvalbumin interneurons: a parsimonious locus of pathophysiological convergence in schizophrenia.
    Mol Psychiatry. 2016 Sep 20. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  25. NIWA M, Cash-Padgett T, Kubo KI, Saito A, et al
    DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1.
    Mol Psychiatry. 2016 Sep 6. doi: 10.1038/mp.2016.
    PubMed     Text format    


    August 2016
  26. DONEGAN JJ, Tyson JA, Branch SY, Beckstead MJ, et al
    Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model.
    Mol Psychiatry. 2016 Aug 2. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    July 2016
  27. KIM MJ, Biag J, Fass DM, Lewis MC, et al
    Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.
    Mol Psychiatry. 2016 Jul 26. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    June 2016
  28. TREPANIER MO, Hopperton KE, Mizrahi R, Mechawar N, et al
    Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review.
    Mol Psychiatry. 2016 Jun 7. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    May 2016
  29. KUSHIMA I, Aleksic B, Nakatochi M, Shimamura T, et al
    High-resolution copy number variation analysis of schizophrenia in Japan.
    Mol Psychiatry. 2016 May 31. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  30. JENKINS AK, Paterson C, Wang Y, Hyde TM, et al
    Neurexin 1 (NRXN1) splice isoform expression during human neocortical development and aging.
    Mol Psychiatry. 2016;21:701-6.
    PubMed     Text format     Abstract available


    April 2016
  31. KEBIR O, Chaumette B, Rivollier F, Miozzo F, et al
    Methylomic changes during conversion to psychosis.
    Mol Psychiatry. 2016 Apr 26. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    March 2016
  32. HOMANN OR, Misura K, Lamas E, Sandrock RW, et al
    Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness.
    Mol Psychiatry. 2016 Mar 22. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    February 2016
  33. HO NF, Iglesias JE, Sum MY, Kuswanto CN, et al
    Progression from selective to general involvement of hippocampal subfields in schizophrenia.
    Mol Psychiatry. 2016 Feb 23. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  34. GOLDSMITH DR, Rapaport MH, Miller BJ
    A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression.
    Mol Psychiatry. 2016 Feb 23. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  35. CARR GV, Chen J, Yang F, Ren M, et al
    KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia.
    Mol Psychiatry. 2016 Feb 9. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  36. MCCLATCHY DB, Savas JN, Martinez-Bartolome S, Park SK, et al
    Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex.
    Mol Psychiatry. 2016;21:205-15.
    PubMed     Text format     Abstract available


  37. LI J, Cai T, Jiang Y, Chen H, et al
    Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database.
    Mol Psychiatry. 2016;21:290-7.
    PubMed     Text format     Abstract available


  38. LU C, Chen Q, Zhou T, Bozic D, et al
    Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3.
    Mol Psychiatry. 2016;21:159-68.
    PubMed     Text format     Abstract available


  39. ROWLAND LM, Krause BW, Wijtenburg SA, McMahon RP, et al
    Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study.
    Mol Psychiatry. 2016;21:198-204.
    PubMed     Text format     Abstract available


  40. KENDLER KS
    The transformation of American psychiatric nosology at the dawn of the twentieth century.
    Mol Psychiatry. 2016;21:152-8.
    PubMed     Text format     Abstract available


    January 2016
  41. OKADA N, Fukunaga M, Yamashita F, Koshiyama D, et al
    Abnormal asymmetries in subcortical brain volume in schizophrenia.
    Mol Psychiatry. 2016 Jan 19. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  42. TROSSBACH SV, Bader V, Hecher L, Pum ME, et al
    Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.
    Mol Psychiatry. 2016 Jan 12. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  43. GUAN L, Wang Q, Wang L, Wu B, et al
    Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain.
    Mol Psychiatry. 2016 Jan 5. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  44. GREEN EK, Rees E, Walters JT, Smith KG, et al
    Copy number variation in bipolar disorder.
    Mol Psychiatry. 2016;21:89-93.
    PubMed     Text format     Abstract available


    December 2015
  45. SELLGREN CM, Kegel ME, Bergen SE, Ekman CJ, et al
    A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.
    Mol Psychiatry. 2015 Dec 15. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  46. TANSEY KE, Rees E, Linden DE, Ripke S, et al
    Common alleles contribute to schizophrenia in CNV carriers.
    Mol Psychiatry. 2015 Dec 8. doi: 10.1038/mp.2015.
    PubMed     Text format    


    September 2015
  47. MCCULLUMSMITH RE, O'Donovan SM, Drummond JB, Benesh FS, et al
    Cell-specific abnormalities of glutamate transporters in schizophrenia: sick astrocytes and compensating relay neurons?
    Mol Psychiatry. 2015 Sep 29. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  48. LANDEK-SALGADO MA, Faust TE, Sawa A
    Molecular substrates of schizophrenia: homeostatic signaling to connectivity.
    Mol Psychiatry. 2015 Sep 22. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  49. TANSEY KE, Rees E, Linden DE, Ripke S, et al
    Common alleles contribute to schizophrenia in CNV carriers.
    Mol Psychiatry. 2015 Sep 22. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  50. COHEN OS, Weickert TW, Hess JL, Paish LM, et al
    A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples.
    Mol Psychiatry. 2015 Sep 8. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  51. MEIER SM, Agerbo E, Maier R, Pedersen CB, et al
    High loading of polygenic risk in cases with chronic schizophrenia.
    Mol Psychiatry. 2015 Sep 1. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


    August 2015
  52. COSTAS J
    The role of SHANK2 rare variants in schizophrenia susceptibility.
    Mol Psychiatry. 2015 Aug 25. doi: 10.1038/mp.2015.
    PubMed     Text format    


  53. PEYKOV S, Berkel S, Degenhardt F, Rietschel M, et al
    Rare SHANK2 variants in schizophrenia.
    Mol Psychiatry. 2015 Aug 25. doi: 10.1038/mp.2015.
    PubMed     Text format    


  54. VAN ERP TG, Hibar DP, Rasmussen JM, Glahn DC, et al
    Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.
    Mol Psychiatry. 2015 Aug 18. doi: 10.1038/mp.2015.
    PubMed     Text format    


  55. TOULOPOULOU T, van Haren N, Zhang X, Sham PC, et al
    Reciprocal causation models of cognitive vs volumetric cerebral intermediate phenotypes for schizophrenia in a pan-European twin cohort.
    Mol Psychiatry. 2015 Aug 18. doi: 10.1038/mp.2015.
    PubMed     Text format    


    July 2015
  56. FILLMAN SG, Weickert TW, Lenroot RK, Catts SV, et al
    Elevated peripheral cytokines characterize a subgroup of people with schizophrenia displaying poor verbal fluency and reduced Broca's area volume.
    Mol Psychiatry. 2015 Jul 21. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  57. PILLAI A, Howell KR, Ahmed AO, Weinberg D, et al
    Association of serum VEGF levels with prefrontal cortex volume in schizophrenia.
    Mol Psychiatry. 2015 Jul 14. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  58. FERNANDES BS, Steiner J, Bernstein HG, Dodd S, et al
    C-reactive protein is increased in schizophrenia but is not altered by antipsychotics: meta-analysis and implications.
    Mol Psychiatry. 2015 Jul 14. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


    June 2015
  59. IWATA Y, Nakajima S, Suzuki T, Keefe RS, et al
    Effects of glutamate positive modulators on cognitive deficits in schizophrenia: a systematic review and meta-analysis of double-blind randomized controlled trials.
    Mol Psychiatry. 2015 Jun 16. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  60. MULLE JG
    The 3q29 deletion confers >40-fold increase in risk for schizophrenia.
    Mol Psychiatry. 2015 Jun 9. doi: 10.1038/mp.2015.
    PubMed     Text format    


  61. VINCKIER F, Gaillard R, Palminteri S, Rigoux L, et al
    Confidence and psychosis: a neuro-computational account of contingency learning disruption by NMDA blockade.
    Mol Psychiatry. 2015 Jun 9. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  62. VAN ERP TG, Hibar DP, Rasmussen JM, Glahn DC, et al
    Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.
    Mol Psychiatry. 2015 Jun 2. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  63. SATTERTHWAITE TD, Vandekar SN, Wolf DH, Bassett DS, et al
    Connectome-wide network analysis of youth with Psychosis-Spectrum symptoms.
    Mol Psychiatry. 2015 Jun 2. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  64. WEICKERT TW, Weinberg D, Lenroot R, Catts SV, et al
    Adjunctive raloxifene treatment improves attention and memory in men and women with schizophrenia.
    Mol Psychiatry. 2015;20:685-94.
    PubMed     Text format     Abstract available


  65. KULKARNI J, Gavrilidis E, Wang W, Worsley R, et al
    Estradiol for treatment-resistant schizophrenia: a large-scale randomized-controlled trial in women of child-bearing age.
    Mol Psychiatry. 2015;20:695-702.
    PubMed     Text format     Abstract available


    March 2015
  66. BRENNAND K, Savas JN, Kim Y, Tran N, et al
    Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia.
    Mol Psychiatry. 2015;20:361-8.
    PubMed     Text format     Abstract available


    February 2015
  67. FRANK J, Lang M, Witt SH, Strohmaier J, et al
    Identification of increased genetic risk scores for schizophrenia in treatment-resistant patients.
    Mol Psychiatry. 2015;20:150-1.
    PubMed     Text format    


  68. ANDREASSEN OA, Harbo HF, Wang Y, Thompson WK, et al
    Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci.
    Mol Psychiatry. 2015;20:207-14.
    PubMed     Text format     Abstract available


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