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  Schizophrenia

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Articles published in Mol Psychiatry

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    August 2017
  1. ALACHKAR A, Wang L, Yoshimura R, Hamzeh AR, et al
    Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits.
    Mol Psychiatry. 2017 Aug 15. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  2. GUR RE, Bassett AS, McDonald-McGinn DM, Bearden CE, et al
    A neurogenetic model for the study of schizophrenia spectrum disorders: the International 22q11.2 Deletion Syndrome Brain Behavior Consortium.
    Mol Psychiatry. 2017 Aug 1. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  3. NIMGAONKAR VL, Prasad KM, Chowdari KV, Severance EG, et al
    The complement system: a gateway to gene-environment interactions in schizophrenia pathogenesis.
    Mol Psychiatry. 2017 Aug 1. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


    July 2017
  4. BENAMER N, Marti F, Lujan R, Hepp R, et al
    GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons.
    Mol Psychiatry. 2017 Jul 11. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


    June 2017
  5. TENG S, Thomson PA, McCarthy S, Kramer M, et al
    Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia.
    Mol Psychiatry. 2017 Jun 20. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


    May 2017
  6. KIM Y, Giusti-Rodriguez P, Crowley JJ, Bryois J, et al
    Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects.
    Mol Psychiatry. 2017 May 30. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  7. WEINSTEIN JJ, van de Giessen E, Rosengard RJ, Xu X, et al
    PET imaging of dopamine-D2 receptor internalization in schizophrenia.
    Mol Psychiatry. 2017 May 16. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  8. MOBERGET T, Doan NT, Alnaes D, Kaufmann T, et al
    Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls.
    Mol Psychiatry. 2017 May 16. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  9. BIRNBAUM R, Jaffe AE, Chen Q, Shin JH, et al
    Investigating the neuroimmunogenic architecture of schizophrenia.
    Mol Psychiatry. 2017 May 9. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  10. TAO R, Davis KN, Li C, Shin JH, et al
    GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia.
    Mol Psychiatry. 2017 May 9. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  11. DEMICHELE-SWEET MAA, Weamer EA, Klei L, Vrana DT, et al
    Genetic risk for schizophrenia and psychosis in Alzheimer disease.
    Mol Psychiatry. 2017 May 2. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


    April 2017
  12. DUNCAN LE, Ratanatharathorn A, Aiello AE, Almli LM, et al
    Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.
    Mol Psychiatry. 2017 Apr 25. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  13. HADAR R, Bikovski L, Soto-Montenegro ML, Schimke J, et al
    Early neuromodulation prevents the development of brain and behavioral abnormalities in a rodent model of schizophrenia.
    Mol Psychiatry. 2017 Apr 4. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


    March 2017
  14. NOTTER T, Meyer U
    Microglia and schizophrenia: where next?
    Mol Psychiatry. 2017 Mar 28. doi: 10.1038/mp.2017.
    PubMed     Text format    


  15. PARKER KL, Kim YC, Kelley RM, Nessler AJ, et al
    Delta-frequency stimulation of cerebellar projections can compensate for schizophrenia-related medial frontal dysfunction.
    Mol Psychiatry. 2017 Mar 28. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  16. LYALL AE, Pasternak O, Robinson DG, Newell D, et al
    Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning.
    Mol Psychiatry. 2017 Mar 28. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  17. DEVOR A, Andreassen OA, Wang Y, Maki-Marttunen T, et al
    Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia.
    Mol Psychiatry. 2017 Mar 28. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  18. STEULLET P, Cabungcal JH, Coyle J, Didriksen M, et al
    Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia.
    Mol Psychiatry. 2017 Mar 21. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  19. CHANG H, Xiao X, Li M
    The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions.
    Mol Psychiatry. 2017 Mar 14. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  20. PAGE SC, Hamersky GR, Gallo RA, Rannals MD, et al
    The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner.
    Mol Psychiatry. 2017 Mar 14. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  21. ROFFMAN JL, Petruzzi LJ, Tanner AS, Brown HE, et al
    Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial.
    Mol Psychiatry. 2017 Mar 14. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


  22. ORHAN F, Fatouros-Bergman H, Goiny M, Malmqvist A, et al
    CSF GABA is reduced in first-episode psychosis and associates to symptom severity.
    Mol Psychiatry. 2017 Mar 14. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


    February 2017
  23. LEE PH, Baker JT, Holmes AJ, Jahanshad N, et al
    Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.
    Mol Psychiatry. 2017 Feb 21. doi: 10.1038/mp.2017.
    PubMed     Text format    


  24. COLLSTE K, Plaven-Sigray P, Fatouros-Bergman H, Victorsson P, et al
    Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28.
    Mol Psychiatry. 2017 Feb 14. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  25. LEE M, Sehatpour P, Hoptman MJ, Lakatos P, et al
    Neural mechanisms of mismatch negativity dysfunction in schizophrenia.
    Mol Psychiatry. 2017 Feb 7. doi: 10.1038/mp.2017.
    PubMed     Text format     Abstract available


    January 2017
  26. MITCHELL AC, Javidfar B, Pothula V, Ibi D, et al
    MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.
    Mol Psychiatry. 2017 Jan 24. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  27. ROALF DR, Nanga RP, Rupert PE, Hariharan H, et al
    Glutamate imaging (GluCEST) reveals lower brain GluCEST contrast in patients on the psychosis spectrum.
    Mol Psychiatry. 2017 Jan 24. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  28. VAUCHER J, Keating BJ, Lasserre AM, Gan W, et al
    Cannabis use and risk of schizophrenia: a Mendelian randomization study.
    Mol Psychiatry. 2017 Jan 24. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  29. NOTTER T, Coughlin JM, Gschwind T, Weber-Stadlbauer U, et al
    Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia.
    Mol Psychiatry. 2017 Jan 17. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  30. QIN XY, Wu HT, Cao C, Loh YP, et al
    A meta-analysis of peripheral blood nerve growth factor levels in patients with schizophrenia.
    Mol Psychiatry. 2017 Jan 10. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  31. ST POURCAIN B, Robinson EB, Anttila V, Sullivan BB, et al
    ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties.
    Mol Psychiatry. 2017 Jan 3. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    December 2016
  32. CLIFTON NE, Pocklington AJ, Scholz B, Rees E, et al
    Schizophrenia copy number variants and associative learning.
    Mol Psychiatry. 2016 Dec 13. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  33. YU H, Yan H, Li J, Li Z, et al
    Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population.
    Mol Psychiatry. 2016 Dec 6. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    November 2016
  34. BADER V, Trossbach SV, Prikulis I, Godsave SF, et al
    Misassembly of non-mutant full-length Disrupted-in-Schizophrenia 1 protein is induced by dopamine in vitro and in vivo.
    Mol Psychiatry. 2016;21:1487.
    PubMed     Text format    


  35. SCARR E, Udawela M, Thomas EA, Dean B, et al
    Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor.
    Mol Psychiatry. 2016 Nov 1. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    October 2016
  36. DELEVICH K, Abi-Dargham A, Hall J, Sawa A, et al
    Studying schizophrenia in the post-genomic era: perspectives from the 2016 summer Banbury Workshop at Cold Spring Harbor Laboratory.
    Mol Psychiatry. 2016 Oct 25. doi: 10.1038/mp.2016.
    PubMed     Text format    


  37. XU J, Hartley BJ, Kurup P, Phillips A, et al
    Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.
    Mol Psychiatry. 2016 Oct 18. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  38. LEE PH, Baker JT, Holmes AJ, Jahanshad N, et al
    Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.
    Mol Psychiatry. 2016 Oct 11. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  39. HASAN A, Wobrock T, Guse B, Langguth B, et al
    Structural brain changes are associated with response of negative symptoms to prefrontal repetitive transcranial magnetic stimulation in patients with schizophrenia.
    Mol Psychiatry. 2016 Oct 11. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  40. HOLMES SE, Hinz R, Drake RJ, Gregory CJ, et al
    In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study.
    Mol Psychiatry. 2016 Oct 4. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    September 2016
  41. STEDEHOUDER J, Kushner SA
    Myelination of parvalbumin interneurons: a parsimonious locus of pathophysiological convergence in schizophrenia.
    Mol Psychiatry. 2016 Sep 20. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  42. NIWA M, Cash-Padgett T, Kubo KI, Saito A, et al
    DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1.
    Mol Psychiatry. 2016 Sep 6. doi: 10.1038/mp.2016.
    PubMed     Text format    


    August 2016
  43. DONEGAN JJ, Tyson JA, Branch SY, Beckstead MJ, et al
    Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model.
    Mol Psychiatry. 2016 Aug 2. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    July 2016
  44. KIM MJ, Biag J, Fass DM, Lewis MC, et al
    Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.
    Mol Psychiatry. 2016 Jul 26. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    June 2016
  45. TREPANIER MO, Hopperton KE, Mizrahi R, Mechawar N, et al
    Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review.
    Mol Psychiatry. 2016 Jun 7. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    May 2016
  46. KUSHIMA I, Aleksic B, Nakatochi M, Shimamura T, et al
    High-resolution copy number variation analysis of schizophrenia in Japan.
    Mol Psychiatry. 2016 May 31. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  47. JENKINS AK, Paterson C, Wang Y, Hyde TM, et al
    Neurexin 1 (NRXN1) splice isoform expression during human neocortical development and aging.
    Mol Psychiatry. 2016;21:701-6.
    PubMed     Text format     Abstract available


    April 2016
  48. KEBIR O, Chaumette B, Rivollier F, Miozzo F, et al
    Methylomic changes during conversion to psychosis.
    Mol Psychiatry. 2016 Apr 26. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    March 2016
  49. HOMANN OR, Misura K, Lamas E, Sandrock RW, et al
    Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness.
    Mol Psychiatry. 2016 Mar 22. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


    February 2016
  50. HO NF, Iglesias JE, Sum MY, Kuswanto CN, et al
    Progression from selective to general involvement of hippocampal subfields in schizophrenia.
    Mol Psychiatry. 2016 Feb 23. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  51. GOLDSMITH DR, Rapaport MH, Miller BJ
    A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression.
    Mol Psychiatry. 2016 Feb 23. doi: 10.1038/mp.2016.
    PubMed     Text format     Abstract available


  52. CARR GV, Chen J, Yang F, Ren M, et al
    KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia.
    Mol Psychiatry. 2016 Feb 9. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  53. MCCLATCHY DB, Savas JN, Martinez-Bartolome S, Park SK, et al
    Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex.
    Mol Psychiatry. 2016;21:205-15.
    PubMed     Text format     Abstract available


  54. LI J, Cai T, Jiang Y, Chen H, et al
    Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database.
    Mol Psychiatry. 2016;21:290-7.
    PubMed     Text format     Abstract available


  55. LU C, Chen Q, Zhou T, Bozic D, et al
    Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3.
    Mol Psychiatry. 2016;21:159-68.
    PubMed     Text format     Abstract available


  56. ROWLAND LM, Krause BW, Wijtenburg SA, McMahon RP, et al
    Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study.
    Mol Psychiatry. 2016;21:198-204.
    PubMed     Text format     Abstract available


  57. KENDLER KS
    The transformation of American psychiatric nosology at the dawn of the twentieth century.
    Mol Psychiatry. 2016;21:152-8.
    PubMed     Text format     Abstract available


    January 2016
  58. OKADA N, Fukunaga M, Yamashita F, Koshiyama D, et al
    Abnormal asymmetries in subcortical brain volume in schizophrenia.
    Mol Psychiatry. 2016 Jan 19. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  59. TROSSBACH SV, Bader V, Hecher L, Pum ME, et al
    Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.
    Mol Psychiatry. 2016 Jan 12. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  60. GUAN L, Wang Q, Wang L, Wu B, et al
    Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain.
    Mol Psychiatry. 2016 Jan 5. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  61. GREEN EK, Rees E, Walters JT, Smith KG, et al
    Copy number variation in bipolar disorder.
    Mol Psychiatry. 2016;21:89-93.
    PubMed     Text format     Abstract available


    December 2015
  62. SELLGREN CM, Kegel ME, Bergen SE, Ekman CJ, et al
    A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.
    Mol Psychiatry. 2015 Dec 15. doi: 10.1038/mp.2015.
    PubMed     Text format     Abstract available


  63. TANSEY KE, Rees E, Linden DE, Ripke S, et al
    Common alleles contribute to schizophrenia in CNV carriers.
    Mol Psychiatry. 2015 Dec 8. doi: 10.1038/mp.2015.
    PubMed     Text format    


    June 2015
  64. KULKARNI J, Gavrilidis E, Wang W, Worsley R, et al
    Estradiol for treatment-resistant schizophrenia: a large-scale randomized-controlled trial in women of child-bearing age.
    Mol Psychiatry. 2015;20:695-702.
    PubMed     Text format     Abstract available


    March 2015
  65. BRENNAND K, Savas JN, Kim Y, Tran N, et al
    Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia.
    Mol Psychiatry. 2015;20:361-8.
    PubMed     Text format     Abstract available


    February 2015
  66. FRANK J, Lang M, Witt SH, Strohmaier J, et al
    Identification of increased genetic risk scores for schizophrenia in treatment-resistant patients.
    Mol Psychiatry. 2015;20:150-1.
    PubMed     Text format    


  67. ANDREASSEN OA, Harbo HF, Wang Y, Thompson WK, et al
    Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci.
    Mol Psychiatry. 2015;20:207-14.
    PubMed     Text format     Abstract available


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