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	Amedeo Prize 2008 The 21 Finalists

Sepsis

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April 2008
1. SPOELSTRA-DE MAN AM , Girbes AR
   Comment on "Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008" by Dellinger et al.
   Intensive Care Med. 2008;.
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2. BION J , Jaeschke R, Thompson BT, Levy M, et al
   Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008.
   Intensive Care Med. 2008;.
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   March 2008
3. BOERMA EC , Kuiper MA, Kingma WP, Egbers PH, et al
   Disparity between skin perfusion and sublingual microcirculatory alterations in severe sepsis and septic shock: a prospective observational study.
   Intensive Care Med. 2008;.
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   February 2008
4. KARLSSON S , Pettila V, Tenhunen J, Laru-Sompa R, et al
   HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis.
   Intensive Care Med. 2008;.
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5. SCHULTZ MJ , de Graaff MJ, Kuiper MA, Spronk PE, et al
   The new Surviving Sepsis Campaign recommendations on glucose control should be reconsidered.
   Intensive Care Med. 2008;.
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6. THOMPSON BT , Clemmer TP, Ahrens T, Levy MM, et al
   The new Surviving Sepsis Campaign recommendations on glucose control: reply to Schultz et al.
   Intensive Care Med. 2008;.
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7. HARAGUCHI G , Kosuge H, Maejima Y, Suzuki JI, et al
   Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis.
   Intensive Care Med. 2008;.
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8. BRUN-BUISSON C
   ICU-acquired infections and Sepsis: More of a deadly duo.
   Intensive Care Med. 2008;.
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   January 2008
9. ANTONELLI M , Azoulay E, Bonten M, Chastre J, et al
   Year in review in Intensive Care Medicine, 2007. II. Haemodynamics, pneumonia, infections and sepsis, invasive and non-invasive mechanical ventilation, acute respiratory distress syndrome.
   Intensive Care Med. 2008;.
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10. BERBEE JF , van der Hoogt CC, de Haas CJ, van Kessel KP, et al
    Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis.
    Intensive Care Med. 2008;.
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11. VANDIJCK DM , Benoit DD, Depuydt PO, Offner FC, et al
    Impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with hematological malignancies.
    Intensive Care Med. 2008;.
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12. MULLER L , Jaber S, Raillard A, Lefrant JY, et al
    Use of recombinant human activated protein C in patients with severe sepsis: a French retrospective multicentre study.
    Intensive Care Med. 2008;.
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13. BOER KR , van Ruler O, van Emmerik AA, Sprangers MA, et al
    Factors associated with posttraumatic stress symptoms in a prospective cohort of patients after abdominal sepsis: a nomogram.
    Intensive Care Med. 2008;.
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14. VAN DEN AKKER EL , Baan CC, van den Berg B, Russcher H, et al
    Ficoll-separated mononuclear cells from sepsis patients are contaminated with granulocytes.
    Intensive Care Med. 2008;.
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    December 2007
15. LANGE M , Ertmer C, Westphal M
    Vasopressin vs. terlipressinin the treatmentof cardiovascular failure in sepsis.
    Intensive Care Med. 2007;.
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16. VILLAR J , Flores C, Perez-Mendez L, Maca-Meyer N, et al
    Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndrome.
    Intensive Care Med. 2007;.
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17. MORENO RP , Metnitz B, Adler L, Hoechtl A, et al
    Sepsis mortality prediction based on predisposition, infection and response.
    Intensive Care Med. 2007;.
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18. DELLINGER RP , Levy MM, Carlet JM, Bion J, et al
    Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008.
    Intensive Care Med. 2007;.
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    November 2007
19. LI Y , Cui X, Li X, Solomon SB, et al
    Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model : Risk and corticosteroids in sepsis.
    Intensive Care Med. 2007;.
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20. SOARES M , Salluh JI, Toscano L, Dias FL, et al
    Outcomes and prognostic factors in patients with head and neck cancer and severe acute illnesses.
    Intensive Care Med. 2007;33:2009-13.
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21. HOWELL MD , Donnino M, Clardy P, Talmor D, et al
    Occult hypoperfusion and mortality in patients with suspected infection.
    Intensive Care Med. 2007;33:1892-9.
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    September 2007
22. MICHALEK J , Svetlikova P, Fedora M, Klimovic M, et al
    Bactericidal permeability increasing protein gene variants in children with sepsis.
    Intensive Care Med. 2007;.
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23. OBERBECK R , Deckert H, Bangen J, Kobbe P, et al
    Dehydroepiandrosterone: a modulator of cellular immunity and heat shock protein 70 production during polymicrobial sepsis.
    Intensive Care Med. 2007;.
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24. LANGENBERG C , Wan L, Egi M, May CN, et al
    Renal blood flow and function during recovery from experimental septic acute kidney injury.
    Intensive Care Med. 2007;33:1614-8.
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25. CHANQUES G , Annane D, Jaber S, Gallix B, et al
    Enlarged adrenals during septic shock.
    Intensive Care Med. 2007;33:1671-2.
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26. CRETEUR J , Carollo T, Soldati G, Buchele G, et al
    The prognostic value of muscle StO2 in septic patients.
    Intensive Care Med. 2007;33:1549-56.
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27. GRIFFITHS J , Fortune G, Barber V, Young JD, et al
    The prevalence of post traumatic stress disorder in survivors of ICU treatment: a systematic review.
    Intensive Care Med. 2007;33:1506-18.
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28. CASARTELLI CH , Garcia PC, Branco RG, Piva JP, et al
    Adrenal response in children with septic shock.
    Intensive Care Med. 2007;33:1609-13.
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29. MORELLI A , Ertmer C, Lange M, Westphal M, et al
    Continuous terlipressin infusion in patients with septic shock: less may be best, and the earlier the better?
    Intensive Care Med. 2007;33:1669-70.
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30. KOZIERAS J , Thuemer O, Sakka SG
    Influence of an acute increase in systemic vascular resistance on transpulmonary thermodilution-derived parameters in critically ill patients.
    Intensive Care Med. 2007;33:1619-23.
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31. DERUDDRE S , Cheisson G, Mazoit JX, Vicaut E, et al
    Renal arterial resistance in septic shock: effects of increasing mean arterial pressure with norepinephrine on the renal resistive index assessed with Doppler ultrasonography.
    Intensive Care Med. 2007;33:1557-62.
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    August 2007
32. DEN BRINKER M , Hokken-Koelega AC, Hazelzet JA, de Jong FH, et al
    One single dose of etomidate negatively influences adrenocortical performance for at least 24[Symbol: see text]h in children with meningococcal sepsis.
    Intensive Care Med. 2007;.
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33. CUI X , Besch V, Khaibullina A, Hergen A, et al
    Neuronal nitric oxide synthase deficiency decreases survival in bacterial peritonitis and sepsis.
    Intensive Care Med. 2007;.
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34. JOHN J , Awab A, Norman D, Dernaika T, et al
    Activated protein C improves survival in severe sepsis patients with elevated troponin.
    Intensive Care Med. 2007;.
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35. TUON L , Comim CM, Antunes MM, Constantino LS, et al
    Imipramine reverses the depressive symptoms in sepsis survivor rats.
    Intensive Care Med. 2007;.
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36. PLATAKI M , Vaporidi K, Georgopoulos D
    Is there increasing evidence that the risks of rhAPC may outweigh its benefits?
    Intensive Care Med. 2007;33:1485-6.
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37. CHENG WE , Shih CM, Hang LW, Wu KY, et al
    Urinary biomarker of oxidative stress correlating with outcome in critically septic patients.
    Intensive Care Med. 2007;33:1468-72.
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38. GARCIA-SEGARRA G , Espinosa G, Tassies D, Oriola J, et al
    Increased mortality in septic shock with the 4G/4G genotype of plasminogen activator inhibitor 1 in patients of white descent.
    Intensive Care Med. 2007;33:1354-62.
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39. GIBOT S , Massin F, Cravoisy A, Barraud D, et al
    High-mobility group box 1 protein plasma concentrations during septic shock.
    Intensive Care Med. 2007;33:1347-53.
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    July 2007
40. MAYBAUER MO , Maybauer DM, Fraser JF, Traber LD, et al
    Ceftazidime improves hemodynamics and oxygenation in ovine smoke inhalation injury and septic shock.
    Intensive Care Med. 2007;33:1219-27.
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41. BAGSHAW SM , Langenberg C, Haase M, Wan L, et al
    Urinary biomarkers in septic acute kidney injury.
    Intensive Care Med. 2007;33:1285-96.
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42. BRUNKHORST FM , Reinhart K
    Intensive insulin therapy in the ICU: benefit versus harm?
    Intensive Care Med. 2007;33:1302.
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43. CHENG WE , Shih CM, Hang LW, Wu KY, et al
    Urinary biomarker of oxidative stress correlating with outcome in critically septic patients.
    Intensive Care Med. 2007;33:1187-90.
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    June 2007
44. SILVA E , Arcaroli J, He Q, Svetkauskaite D, et al
    HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury.
    Intensive Care Med. 2007;.
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45. MATEJOVIC M , Radermacher P, Joannidis M
    Acute kidney injury in sepsis: Is renal blood flow more than just an innocent bystander?
    Intensive Care Med. 2007;.
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46. BRENMOEHL J , Herfarth H, Gluck T, Audebert F, et al
    Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients.
    Intensive Care Med. 2007;.
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47. ALBUSZIES G , Vogt J, Wachter U, Thiemermann C, et al
    The effect of iNOS deletion on hepatic gluconeogenesis in hyperdynamic murine septic shock.
    Intensive Care Med. 2007;33:1094-101.
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48. NIELSEN JS , Larsson A, Rix T, Nyboe R, et al
    The effect of activated protein C on plasma cytokine levels in a porcine model of acute endotoxemia.
    Intensive Care Med. 2007;33:1085-93.
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49. LORENTE L , Jimenez A, Castedo J, Galvan R, et al
    Internal jugular venous catheter-related bacteremia according to central and posterior accesses.
    Intensive Care Med. 2007;33:1071-5.
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50. TRZECIAK S , Dellinger RP, Chansky ME, Arnold RC, et al
    Serum lactate as a predictor of mortality in patients with infection.
    Intensive Care Med. 2007;33:970-7.
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51. FEISSEL M , Teboul JL, Merlani P, Badie J, et al
    Plethysmographic dynamic indices predict fluid responsiveness in septic ventilated patients.
    Intensive Care Med. 2007;33:993-9.
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    May 2007
52. BOOST KA , Hoegl S, Hofstetter C, Flondor M, et al
    Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia.
    Intensive Care Med. 2007;33:863-71.
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53. SHARSHAR T , Carlier R, Bernard F, Guidoux C, et al
    Brain lesions in septic shock: a magnetic resonance imaging study.
    Intensive Care Med. 2007;33:798-806.
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    April 2007
54. EBERSOLDT M , Sharshar T, Annane D
    Sepsis-associated delirium.
    Intensive Care Med. 2007;.
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55. PAVCNIK-ARNOL M , Hojker S, Derganc M
    Lipopolysaccharide-binding protein, lipopolysaccharide, and soluble CD14 in sepsis of critically ill neonates and children.
    Intensive Care Med. 2007;.
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56. RUSSELL C
    Comment on Vieillard-Baron et al.: "Bedside echocardiographic evaluation of hemodynamics in sepsis: is qualitative evaluation sufficient?"
    Intensive Care Med. 2007;.
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57. VIEILLARD-BARON A , Jardin F
    "Bedside echocardiography evaluation of hemodynamics in sepsis: is qualitative evaluation sufficient?": reply to Russell.
    Intensive Care Med. 2007;.
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58. WEBER-CARSTENS S , Deja M, Bercker S, Dimroth A, et al
    Impact of bolus application of low-dose hydrocortisone on glycemic control in septic shock patients.
    Intensive Care Med. 2007;33:730-3.
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59. TEMMESFELD-WOLLBRUCK B , Brell B, David I, Dorenberg M, et al
    Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock.
    Intensive Care Med. 2007;33:703-10.
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    March 2007
60. MATUTE-BELLO G
    Targeting caspase-1 in sepsis: a novel approach to an old problem.
    Intensive Care Med. 2007;.
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61. KANJI S , Perreault MM, Chant C, Williamson D, et al
    Evaluating the use of Drotrecogin alfa (activated) in adult severe sepsis: a Canadian multicenter observational study.
    Intensive Care Med. 2007;33:517-23.
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62. RANIERI VM , Moreno RP, Rhodes A
    The European Society of Intensive Care Medicine (ESICM) and the Surviving Sepsis Campaign (SSC).
    Intensive Care Med. 2007;33:423-5.
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63. BERTOLINI G , Rossi C, Anghileri A, Livigni S, et al
    Use of Drotrecogin alfa (activated) in Italian intensive care units: the results of a nationwide survey.
    Intensive Care Med. 2007;33:426-34.
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64. EICHACKER PQ , Natanson C
    Increasing evidence that the risks of rhAPC may outweigh its benefits.
    Intensive Care Med. 2007;33:396-9.
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65. DUBIN A , Murias G, Sottile JP, Pozo MO, et al
    Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study.
    Intensive Care Med. 2007;33:485-94.
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66. DE BACKER D , Taccone FS, Radermacher P
    Levosimendan in septic shock: another piece in the puzzle, but many pieces are still lacking.
    Intensive Care Med. 2007;33:403-5.
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67. DROOGH JM , Noppers IM, Tulleken JE, Meertens JH, et al
    Comment on Mackenzie and Woodhouse: C-reactive protein concentrations during bacteraemia: a comparison between patients with and without liver dysfunction.
    Intensive Care Med. 2007;33:561.
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68. CHENG AC , Currie BJ
    Serum C-reactive protein and liver disease in patients with melioidosis.
    Intensive Care Med. 2007;33:562.
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69. LEVY B , Mansart A, Montemont C, Gibot S, et al
    Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock.
    Intensive Care Med. 2007;33:495-502.
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70. MATEJOVIC M , Radermacher P, Fontaine E
    Lactate in shock: a high-octane fuel for the heart?
    Intensive Care Med. 2007;33:406-8.
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71. GARCIA-TERESA MA , Casado-Flores J, Delgado Dominguez MA, Roqueta-Mas J, et al
    Infectious complications of percutaneous central venous catheterization in pediatric patients: a Spanish multicenter study.
    Intensive Care Med. 2007;33:466-76.
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72. BOURDEAUX C , Hadfield J
    Comment on Varpula et al.: Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock.
    Intensive Care Med. 2007;33:545.
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73. LIGTENBERG JJ , Monteban-Kooistra WE, Meertens JH, Tulleken JE, et al
    The ACTH test should not be used in the decision to start low dose steroids in catecholamine-dependent septic shock.
    Intensive Care Med. 2007;33:551.
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74. TANIGUCHI T , Kurita A, Mukawa C, Yamamoto K, et al
    Dose-related effects of direct hemoperfusion using a cytokine adsorbent column for the treatment of experimental endotoxemia.
    Intensive Care Med. 2007;33:529-33.
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    February 2007
75. ENGEL C , Brunkhorst FM, Bone HG, Brunkhorst R, et al
    Epidemiology of sepsis in Germany: results from a national prospective multicenter study.
    Intensive Care Med. 2007;.
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76. RUBULOTTA F , Gullo A, Iscra F
    Recommendations for ulcer prophylaxis in the treatment of patients with severe sepsis and septic shock: a dog chasing its tail?
    Intensive Care Med. 2007;.
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77. CALLISTER ME , Burke-Gaffney A, Quinlan GJ, Betts H, et al
    Persistently low plasma thioredoxin is associated with meningococcal septic shock in children.
    Intensive Care Med. 2007;33:364-7.
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    January 2007
78. KARLSSON S , Varpula M, Ruokonen E, Pettila V, et al
    Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study.
    Intensive Care Med. 2007;.
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79. ANDREWS P , Azoulay E, Antonelli M, Brochard L, et al
    Year in review in Intensive Care Medicine, 2006. II. Infections and sepsis, haemodynamics, elderly, invasive and noninvasive mechanical ventilation, weaning, ARDS.
    Intensive Care Med. 2007;.
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80. GUISSET O , Dilhuydy MS, Thiebaut R, Lefevre J, et al
    Decrease in circulating dendritic cells predicts fatal outcome in septic shock.
    Intensive Care Med. 2007;33:148-52.
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    December 2006
81. OZDEMIR D , Uysal N, Tugyan K, Gonenc S, et al
    The effect of melatonin on endotoxemia-induced intestinal apoptosis and oxidative stress in infant rats.
    Intensive Care Med. 2006;.
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82. GEROULANOS S , Douka ET
    Historical perspective of the word "sepsis".
    Intensive Care Med. 2006;32:2077.
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    November 2006
83. MURCH O , Collin M, Hinds CJ, Thiemermann C, et al
    Lipoproteins in inflammation and sepsis. I. Basic science.
    Intensive Care Med. 2006;.
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84. WENDEL M , Paul R, Heller AR
    Lipoproteins in inflammation and sepsis. II. Clinical aspects.
    Intensive Care Med. 2006;.
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85. LAUZIER F , Levy B, Lamarre P, Lesur O, et al
    Vasopressin or norepinephrine in early hyperdynamic septic shock: a randomized clinical trial.
    Intensive Care Med. 2006;32:1782-9.
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86. LORENTE L , Jimenez A, Jimenez JJ, Iribarren JL, et al
    The catheter site influences in the micro-organism responsible of arterial catheter-related infection.
    Intensive Care Med. 2006;32:1919-20.
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87. COHEN J , Ward G, Prins J, Jones M, et al
    Variability of cortisol assays can confound the diagnosis of adrenal insufficiency in the critically ill population.
    Intensive Care Med. 2006;32:1901-5.
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88. DEPUYDT P , Benoit D, Vogelaers D, Claeys G, et al
    Outcome in bacteremia associated with nosocomial pneumonia and the impact of pathogen prediction by tracheal surveillance cultures.
    Intensive Care Med. 2006;32:1773-81.
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89. LE BLANC L , Lesur O, Valiquette L, St-Pierre C, et al
    Role of routine blood cultures in detecting unapparent infections during continuous renal replacement therapy.
    Intensive Care Med. 2006;32:1802-7.
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90. SUFFREDINI AF , Chanock SJ
    Genetic variation and the assessment of risk in septic patients.
    Intensive Care Med. 2006;32:1679-80.
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    October 2006
91. HASIBEDER W , Knotzer H, Friesenecker B, Dunser M, et al
    Comment on "Sublingual capnometry tracks microcirculatory changes in septic patients" by Creteur et al.
    Intensive Care Med. 2006;32:1665-6.
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92. LEROLLE N , Guerot E, Faisy C, Bornstain C, et al
    Renal failure in septic shock: predictive value of Doppler-based renal arterial resistive index.
    Intensive Care Med. 2006;32:1553-9.
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93. CHARLES PE , Dalle F, Aho S, Quenot JP, et al
    Serum procalcitonin measurement contribution to the early diagnosis of candidemia in critically ill patients.
    Intensive Care Med. 2006;32:1577-83.
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    September 2006
94. JORGENSEN VL , Nielsen SL, Espersen K, Perner A, et al
    Increased colorectal permeability in patients with severe sepsis and septic shock.
    Intensive Care Med. 2006;.
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95. CLARK MF , Baudouin SV
    A systematic review of the quality of genetic association studies in human sepsis.
    Intensive Care Med. 2006;.
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96. JONES A , Webb I, Gibbs T, Beale R, et al
    Discordant response to ACTH stimulation in patients with septic shock.
    Intensive Care Med. 2006;32:1440-1.
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97. VARPULA M , Karlsson S, Ruokonen E, Pettila V, et al
    Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock.
    Intensive Care Med. 2006;32:1336-43.
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98. YEBENES JC , Serra-Prat M, Miro G, Sauca G, et al
    Differences in time to positivity can affect the negative predictive value of blood cultures drawn through a central venous catheter.
    Intensive Care Med. 2006;32:1442-3.
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99. SIRVENT JM , Vidaur L, Garcia M, Ortiz P, et al
    Colonization of the medial lumen is a risk factor for catheter-related bloodstream infection.
    Intensive Care Med. 2006;32:1404-8.
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100. LORENTE L , Jimenez A, Iribarren JL, Jimenez JJ, et al
     The micro-organism responsible for central venous catheter related bloodstream infection depends on catheter site.
     Intensive Care Med. 2006;32:1449-50.
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101. MACKENZIE I , Woodhouse J
     C-reactive protein concentrations during bacteraemia: A comparison between patients with and without liver dysfunction.
     Intensive Care Med. 2006;32:1344-51.
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     August 2006
102. MOREL J , Venet C, Donati Y, Charier D, et al
     Adrenal axis function does not appear to be associated with hemodynamic improvement in septic shock patients systematically receiving glucocorticoid therapy.
     Intensive Care Med. 2006;32:1184-90.
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103. WAN L , Bellomo R, May CN
     The effect of normal saline resuscitation on vital organ blood flow in septic sheep.
     Intensive Care Med. 2006;32:1238-42.
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104. MONNERET G , Lepape A, Voirin N, Bohe J, et al
     Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock.
     Intensive Care Med. 2006;32:1175-83.
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