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  Tuberculosis

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Articles published in Antimicrob Agents Chemother

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    March 2017
  1. XU J, Wang B, Hu M, Huo F, et al
    Primary clofazimine and bedaquiline resistance among isolates from patients with multidrug-resistant tuberculosis.
    Antimicrob Agents Chemother. 2017 Mar 20. pii: AAC.00239.
    PubMed     Text format     Abstract available


  2. ALSULTAN A, Savic R, Dooley KE, Weiner M, et al
    Population Pharmacokinetics of Pyrazinamide in Patients with Tuberculosis.
    Antimicrob Agents Chemother. 2017 Mar 13. pii: AAC.02625.
    PubMed     Text format     Abstract available


  3. VELASQUEZ GE, Calderon RI, Mitnick CD, Becerra MC, et al
    Erratum for Velasquez et al., Pyrazinamide Resistance Assays and Two-Month Sputum Culture Status in Patients with Multidrug-Resistant Tuberculosis.
    Antimicrob Agents Chemother. 2017;61.
    PubMed     Text format    


    February 2017
  4. RAMACHANDRAN G, Kumar AK, Chandrasekaran V, Kannan T, et al
    Factors influencing tuberculosis treatment outcome in adult patients treated with thrice-weekly regimens in India.
    Antimicrob Agents Chemother. 2017 Feb 27. pii: AAC.02464.
    PubMed     Text format     Abstract available


  5. KAYIGIRE XA, Friedrich SO, van der Merwe L, Diacon AH, et al
    Acquisition of rifampin resistance in pulmonary tuberculosis.
    Antimicrob Agents Chemother. 2017 Feb 6. pii: AAC.02220.
    PubMed     Text format     Abstract available


    January 2017
  6. AJILEYE A, Alvarez N, Merker M, Walker TM, et al
    Some synonymous and non-synonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-resistance results to fluoroquinolones with the Hain GenoType MTBDRsl assays.
    Antimicrob Agents Chemother. 2017 Jan 30. pii: AAC.02169.
    PubMed     Text format     Abstract available


  7. DE JAGER V, van der Merwe L, Venter A, Donald PR, et al
    Time trends in sputum mycobacterial load and 2-day bactericidal activity of INH-containing anti-tuberculosis therapies.
    Antimicrob Agents Chemother. 2017 Jan 30. pii: AAC.02088.
    PubMed     Text format     Abstract available


  8. KUMAR P, Kaushik A, Bell D, Chauhan V, et al
    Mutation in an unannotated protein confers carbapenem resistance in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2017 Jan 9. pii: AAC.02234.
    PubMed     Text format     Abstract available


  9. VAN ALTENA R, Dijkstra JA, van der Meer ME, Borjas Howard JF, et al
    Reduced chance of hearing loss associated with Therapeutic Drug Monitoring of Aminoglycosides in the treatment of Multidrug Resistant Tuberculosis.
    Antimicrob Agents Chemother. 2017 Jan 9. pii: AAC.01400.
    PubMed     Text format     Abstract available


  10. SCHUMP MD, Fox DM, Bertozzi CR, Riley LW, et al
    Subcellular Partitioning and Intra-Macrophage Selectivity of Antimicrobial Compounds Against Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2017 Jan 4. pii: AAC.01639.
    PubMed     Text format     Abstract available


    December 2016
  11. IACOBINO A, Piccaro G, Giannoni F, Mustazzolu A, et al
    Mycobacterium tuberculosis is selectively killed by rifampin and rifapentine in hypoxia at neutral pH.
    Antimicrob Agents Chemother. 2016 Dec 19. pii: AAC.02296.
    PubMed     Text format     Abstract available


  12. FOFANA MO, Shrestha S, Knight GM, Cohen T, et al
    Role of pyrazinamide in the emergence of extensively drug-resistant tuberculosis: a multi-strain mathematical model.
    Antimicrob Agents Chemother. 2016 Dec 12. pii: AAC.00498.
    PubMed     Text format     Abstract available


  13. PANG Y, Zhang Z, Wang Y, Wang S, et al
    Genotyping and prevalence of pyrazinamide- and moxifloxacin-resistant tuberculosis in China, 2000-2010: findings from the national survey data.
    Antimicrob Agents Chemother. 2016 Dec 5. pii: AAC.02170.
    PubMed     Text format     Abstract available


    November 2016
  14. BROSSIER F, Pham A, Bernard C, Aubry A, et al
    Molecular investigation of resistance to second line injectable drugs in multidrug-resistant clinical isolates of Mycobacterium tuberculosis in France.
    Antimicrob Agents Chemother. 2016 Nov 28. pii: AAC.01299.
    PubMed     Text format     Abstract available


  15. SEBASTIAN J, Swaminath S, Nair RR, Jakkala K, et al
    De Novo Emergence of Genetically Resistant Mutants of Mycobacterium tuberculosis from the Persistence Phase Cells formed against Antituberculosis Drugs In Vitro.
    Antimicrob Agents Chemother. 2016 Nov 28. pii: AAC.01343.
    PubMed     Text format     Abstract available


  16. YEE M, Gopal P, Dick T
    Missense mutations in the unfoldase ClpC1 of the caseinolytic protease complex are associated with pyrazinamide resistance in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2016 Nov 21. pii: AAC.02342.
    PubMed     Text format     Abstract available


  17. ROSEN BC, Dillon NA, Peterson ND, Minato Y, et al
    Long-Chain Fatty Acyl-CoA Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2016 Nov 14. pii: AAC.02130.
    PubMed     Text format     Abstract available


  18. ANTWI S, Yang H, Enimil A, Sarfo AM, et al
    Pharmacokinetics of the First-line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with and without HIV Coinfection.
    Antimicrob Agents Chemother. 2016 Nov 14. pii: AAC.01701.
    PubMed     Text format     Abstract available


  19. ALFFENAAR JC, Akkerman OW, van Hest R
    Statin Adjunctive Therapy for Tuberculosis Treatment.
    Antimicrob Agents Chemother. 2016;60:7004.
    PubMed     Text format    


    October 2016
  20. PHOLWAT S, Stroup S, Heysell S, Ogarkov O, et al
    Eis C-14G and C-15G mutations do not confer kanamycin resistance in M. tuberculosis.
    Antimicrob Agents Chemother. 2016 Oct 10. pii: AAC.01775.
    PubMed     Text format     Abstract available


    September 2016
  21. WANG X, Yang S, Gu J, Deng J, et al
    Mycobacterium tuberculosis arylamine N-acetyltransferase acetylates and thus inactivates para-aminosalicylic acid.
    Antimicrob Agents Chemother. 2016 Sep 26. pii: AAC.01312.
    PubMed     Text format     Abstract available


  22. LI Y, Wang Y, Zhang Z, Gao H, et al
    Association between embB Codon 306 Mutations, Phenotypic Resistance Profiles and Genotypic Characterization in Clinical Mycobacterium tuberculosis Isolates from Hebei, China.
    Antimicrob Agents Chemother. 2016 Sep 26. pii: AAC.00532.
    PubMed     Text format     Abstract available


    August 2016
  23. NARAN K, Moosa A, Barry CE 3rd, Boshoff HI, et al
    Bioluminescent reporters for rapid mechanism of action assessment in tuberculosis drug discovery.
    Antimicrob Agents Chemother. 2016 Aug 29. pii: AAC.01178.
    PubMed     Text format     Abstract available


  24. ZHANG D, Gomez JE, Chien JY, Haseley N, et al
    Genomic analysis of the evolution of fluoroquinolone resistance in Mycobacterium tuberculosis prior to tuberculosis diagnosis.
    Antimicrob Agents Chemother. 2016 Aug 29. pii: AAC.00664.
    PubMed     Text format     Abstract available


  25. FURIN JJ, Du Bois J, van Brakel E, Chheng P, et al
    Early Bactericidal Activity of AZD5847 in Pulmonary Tuberculosis.
    Antimicrob Agents Chemother. 2016 Aug 22. pii: AAC.01163.
    PubMed     Text format     Abstract available


  26. CHUANG YM, Dutta NK, Hung CF, Wu TC, et al
    The stringent response factors PPX1 and PPK2 play an important role in Mycobacterium tuberculosis metabolism, biofilm formation, and sensitivity to isoniazid in vivo.
    Antimicrob Agents Chemother. 2016 Aug 15. pii: AAC.01139.
    PubMed     Text format     Abstract available


  27. FOO CS, Lechartier B, Kolly GS, Boy-Rottger S, et al
    Characterization of DprE1-mediated benzothiazinone resistance in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2016 Aug 15. pii: AAC.01523.
    PubMed     Text format     Abstract available


  28. NIKONENKO BV, Kornienko A, Majorov K, Ivanov P, et al
    In vitro activity of 3-triazenoindoles against Mycobacterium tuberculosis and Mycobacterium avium.
    Antimicrob Agents Chemother. 2016 Aug 8. pii: AAC.00998.
    PubMed     Text format     Abstract available


  29. PALENCIA A, Li X, Bu W, Choi W, et al
    Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase.
    Antimicrob Agents Chemother. 2016 Aug 8. pii: AAC.01339.
    PubMed     Text format     Abstract available


  30. CORDES H, Thiel C, Aschmann HE, Baier V, et al
    A PBPK model of isoniazid and its application in individualizing tuberculosis chemotherapy.
    Antimicrob Agents Chemother. 2016 Aug 1. pii: AAC.00508.
    PubMed     Text format     Abstract available


  31. ROCKWOOD NN, Meintjes G, Chirehwa M, Wiesner L, et al
    HIV-1 co-infection does not reduce exposure to rifampicin, isoniazid, and pyrazinamide in South African tuberculosis outpatients.
    Antimicrob Agents Chemother. 2016 Aug 1. pii: AAC.00480.
    PubMed     Text format     Abstract available


  32. PROSSER GA, Rodenburg A, Khoury H, de Chiara C, et al
    Glutamate racemase is the primary target of beta-chloro-D-alanine in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2016 Aug 1. pii: AAC.01249.
    PubMed     Text format     Abstract available


    July 2016
  33. MODONGO C, Pasipanodya JG, Magazi BT, Srivastava S, et al
    Artificial intelligence and amikacin exposures predictive of outcome in multidrug-resistant tuberculosis patients.
    Antimicrob Agents Chemother. 2016 Jul 25. pii: AAC.00962.
    PubMed     Text format     Abstract available


  34. GARCIA-GARCIA V, Oldfield E, Benaim G
    Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109.
    Antimicrob Agents Chemother. 2016 Jul 25. pii: AAC.00945.
    PubMed     Text format     Abstract available


  35. SRIVASTAVA S, Modongo C, Siyambalapitiyage Dona CW, Pasipanodya JG, et al
    Amikacin optimal exposures targets in the hollow fiber system model of tuberculosis.
    Antimicrob Agents Chemother. 2016 Jul 25. pii: AAC.00961.
    PubMed     Text format     Abstract available


  36. SHAH S, Dalecki AG, Malalasekera AP, Crawford CL, et al
    8-Hydroxyquinolines are boosting-agents of copper related toxicity in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2016 Jul 18. pii: AAC.00325.
    PubMed     Text format     Abstract available


    June 2016
  37. YU X, Wang G, Chen S, Wei G, et al
    Mycobacterium tuberculosis wild-type and non-wild-type MIC distributions for the novel fluoroquinolone antofloxacin compared with ofloxacin, levofloxacin, and moxifloxacin.
    Antimicrob Agents Chemother. 2016 Jun 20. pii: AAC.00393.
    PubMed     Text format     Abstract available


  38. DISRATTHAKIT A, Prammananan T, Tribuddharat C, Thaipisuttikul I, et al
    Gyrase Mutations in Pre-extensively and Extensively Drug-resistant Tuberculosis in Thai Clinical Isolates: Insights into the Role of gyrB Mutations in Quinolone Resistance.
    Antimicrob Agents Chemother. 2016 Jun 13. pii: AAC.00539.
    PubMed     Text format     Abstract available


  39. LI W, Obregon-Henao A, Wallach JB, North EJ, et al
    Therapeutic potential of the Mycobacterium tuberculosis mycolic acid transporter, MmpL3.
    Antimicrob Agents Chemother. 2016 Jun 13. pii: AAC.00826.
    PubMed     Text format     Abstract available


  40. LI D, Hu Y, Werngren J, Mansjo M, et al
    Emergence and genetic characteristics of pyrazinamide resistant tuberculosis in China, a multi-center study.
    Antimicrob Agents Chemother. 2016 Jun 13. pii: AAC.02687.
    PubMed     Text format     Abstract available


  41. DEN HERTOG AL, Menting S, Pfeltz R, Warns M, et al
    PZA is active against Mycobacterium tuberculosis cultures at neutral pH with reduced temperature.
    Antimicrob Agents Chemother. 2016 Jun 6. pii: AAC.00654.
    PubMed     Text format     Abstract available


    May 2016
  42. ZHENG X, Zheng R, Hu Y, Werngren J, et al
    Determination of Minimum Inhibitory Concentration (MIC) Breakpoints for second-line drugs associated with clinical outcomes in multidrug-resistant tuberculosis treatment in China.
    Antimicrob Agents Chemother. 2016 May 31. pii: AAC.03008.
    PubMed     Text format     Abstract available


  43. HU Y, Pertinez H, Ortega-Muro F, Alameda-Martin L, et al
    Investigation of elimination rate, persistent subpopulation removal and relapse rates of Mycobacterium tuberculosis by combinations of first-line drugs in a modified Cornell mouse model.
    Antimicrob Agents Chemother. 2016 May 23. pii: AAC.02548.
    PubMed     Text format     Abstract available


  44. CHIEN JY, Chien ST, Chiu WY, Yu CJ, et al
    Moxifloxacin Improves Treatment Outcomes in Patients with Ofloxacin-resistant Multidrug-resistant Tuberculosis.
    Antimicrob Agents Chemother. 2016 May 23. pii: AAC.00425.
    PubMed     Text format     Abstract available


  45. ALMEIDA D, Ioerger T, Tyagi S, Li SY, et al
    Mutations in pepQ Confer Low-level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2016 May 16. pii: AAC.00753.
    PubMed     Text format     Abstract available


  46. LINGARAJU S, Rigouts L, Gupta A, Lee J, et al
    Geographic differences in the contribution of ubiA mutations to high-level Ethambutol Resistance in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2016 May 2. pii: AAC.03002.
    PubMed     Text format     Abstract available


  47. LANOIX JP, Tasneen R, O'Brien P, Sarathy J, et al
    High systemic exposure of pyrazinoic acid has limited anti-tuberculosis activity in murine and rabbit models of tuberculosis.
    Antimicrob Agents Chemother. 2016 May 2. pii: AAC.03085.
    PubMed     Text format     Abstract available


    April 2016
  48. LEE JY, Lee HJ, Kim YK, Yu S, et al
    Impact of Fluoroquinolone Exposure Prior to Tuberculosis Diagnosis on Clinical Outcomes in Immunocompromised Patients.
    Antimicrob Agents Chemother. 2016 Apr 18. pii: AAC.01749.
    PubMed     Text format     Abstract available


  49. GEORGHIOU SB, Seifert M, Catanzaro D, Garfein RS, et al
    Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Cape.
    Antimicrob Agents Chemother. 2016 Apr 18. pii: AAC.00222.
    PubMed     Text format     Abstract available


  50. ALSAAD N, Dijkstra JA, Akkerman OW, de Lange WC, et al
    A pharmacokinetic evaluation of sulfamethoxazole 800 mg once daily in the treatment of tuberculosis.
    Antimicrob Agents Chemother. 2016 Apr 11. pii: AAC.02175.
    PubMed     Text format     Abstract available


  51. EARLY JV, Casey A, Martinez-Grau MA, Valcarcel IC, et al
    Oxadiazoles have butyrate-specific conditional activity against Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2016 Apr 4. pii: AAC.02896.
    PubMed     Text format     Abstract available


    March 2016
  52. MORADIGARAVAND D, Grandjean L, Martinez E, Li H, et al
    DfrA-thyA double deletion in para-aminosalicylic acid resistant Mycobacterium tuberculosis Beijing strains.
    Antimicrob Agents Chemother. 2016 Mar 28. pii: AAC.00253.
    PubMed     Text format     Abstract available


  53. PARVEZ MM, Jung JA, Shin HJ, Kim DH, et al
    Characterization of 22 anti-tuberculosis drugs for the inhibitory interaction potential on organic anionic transporter polypeptides (OATPs) mediated uptake.
    Antimicrob Agents Chemother. 2016 Mar 14. pii: AAC.02765.
    PubMed     Text format     Abstract available


  54. STINSON K, Kurepina N, Venter A, Fujiwara M, et al
    Minimum Inhibitory Concentration of Delamanid (OPC-67683) against Mycobacterium tuberculosis Clinical Isolates and a Proposed Critical Concentration.
    Antimicrob Agents Chemother. 2016 Mar 14. pii: AAC.03014.
    PubMed     Text format     Abstract available


  55. MAKAFE GG, Cao Y, Tan Y, Julius M, et al
    Oxazolidinone Resistance in Mycobacterium tuberculosis: What is the Role of Cys154Arg Mutation in the Ribosomal Protein L3?
    Antimicrob Agents Chemother. 2016 Mar 7. pii: AAC.00152.
    PubMed     Text format     Abstract available


    February 2016
  56. SRIVASTAVA S, van Rijn SP, Wessels AM, Alffenaar JC, et al
    Susceptibility testing of antibiotics that degrade faster than the doubling-time of slow growing Mycobacteria; Ertapenem sterilizing effect versus Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2016 Feb 29. pii: AAC.02924.
    PubMed     Text format     Abstract available


  57. SWANSON R, Ammerman N, Ngcobo B, Adamson J, et al
    Clofazimine contributes sustained antimicrobial activity after treatment cessation in the mouse model of tuberculosis chemotherapy.
    Antimicrob Agents Chemother. 2016 Feb 29. pii: AAC.00177.
    PubMed     Text format     Abstract available


  58. HENDON-DUNN CL, Doris KS, Thomas SR, Allnutt JC, et al
    A flow cytometry method for rapidly assessing M. tuberculosis responses to antibiotics with different modes of action.
    Antimicrob Agents Chemother. 2016 Feb 22. pii: AAC.02712.
    PubMed     Text format     Abstract available


  59. LI QJ, Jiao WW, Yin QQ, Xu F, et al
    Compensatory Mutations of Rifampicin Resistance Are Associated with Transmission of Multidrug Resistant Mycobacterium tuberculosis Beijing genotype strains in China.
    Antimicrob Agents Chemother. 2016 Feb 22. pii: AAC.02358.
    PubMed     Text format     Abstract available


  60. PEARSON CS, Kloos Z, Murray B, Tabe E, et al
    Combined Bioinformatic and Rational Design Approach to Develop Antimicrobial Peptides against Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2016 Feb 22. pii: AAC.00940.
    PubMed     Text format     Abstract available


  61. SCHERR N, Pluschke G, Panda M
    A comparative study of activities of a diverse set of anti-mycobacterial agents against Mycobacterium tuberculosis and Mycobacterium ulcerans.
    Antimicrob Agents Chemother. 2016 Feb 16. pii: AAC.02658.
    PubMed     Text format     Abstract available


  62. TURAPOV O, O'Connor BD, Sarybaeva AA, Williams C, et al
    Phenotypically adapted Mycobacterium tuberculosis populations from sputum are tolerant to first line drugs.
    Antimicrob Agents Chemother. 2016 Feb 16. pii: AAC.01380.
    PubMed     Text format     Abstract available


  63. DAS MK, Arya R, Debnath S, Debnath R, et al
    Global urine metabolomics of first line tuberculosis drug treated patients and identification of a novel metabolite of ethambutol.
    Antimicrob Agents Chemother. 2016 Feb 1. pii: AAC.02586.
    PubMed     Text format     Abstract available


    January 2016
  64. ZHANG S, Chen J, Cui P, Shi W, et al
    Mycobacterium tuberculosis Mutations Associated with Reduced Susceptibility to Linezolid.
    Antimicrob Agents Chemother. 2016 Jan 25. pii: AAC.02941.
    PubMed     Text format     Abstract available


  65. BEKKER A, Schaaf HS, Draper HR, van der Laan L, et al
    The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in infants dosed at revised WHO-recommended treatment guidelines.
    Antimicrob Agents Chemother. 2016 Jan 25. pii: AAC.02600.
    PubMed     Text format     Abstract available


  66. CHIEN JY, Chiu WY, Chien ST, Chiang CJ, et al
    Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-resistant Mycobacterium tuberculosis Isolates.
    Antimicrob Agents Chemother. 2016 Jan 19. pii: AAC.01049.
    PubMed     Text format     Abstract available


  67. NUERMBERGER E, Sizemore C, Romero K, Hanna D, et al
    Towards an evidence-based non-clinical roadmap for evaluating the efficacy of new TB drug regimens: Proceedings of a Critical Path to TB Drug Regimens (CPTR)-National Institute of Allergy and Infectious Disease (NIAID) in vivo Pharmacology Workshop fo
    Antimicrob Agents Chemother. 2016 Jan 11. pii: AAC.02041.
    PubMed     Text format     Abstract available


    December 2015
  68. LANOIX JP, Betoudji F, Nuermberger E
    Sterilizing activity of pyrazinamide in combination with first-line drugs in a C3HeB/FeJ mouse model of tuberculosis.
    Antimicrob Agents Chemother. 2015 Dec 7. pii: AAC.02637.
    PubMed     Text format     Abstract available


  69. DENTI P, Martinson N, Cohn S, Mashabela F, et al
    Population pharmacokinetics of rifampicin in pregnant women with tuberculosis and HIV co-infection in Soweto, South Africa.
    Antimicrob Agents Chemother. 2015 Dec 7. pii: AAC.02051.
    PubMed     Text format     Abstract available


    November 2015
  70. LANOIX JP, Ioerger T, Ormond A, Kaya F, et al
    Selective inactivity of pyrazinamide against tuberculosis in C3HeB/FeJ mice is best explained by neutral pH of caseum.
    Antimicrob Agents Chemother. 2015 Nov 16. pii: AAC.01370.
    PubMed     Text format     Abstract available


  71. CHIREHWA MT, Rustomjee R, Mthiyane T, Onyebujoh P, et al
    Model-based evaluation of higher doses of rifampicin using a semi-mechanistic model incorporating auto-induction and saturation of hepatic extraction.
    Antimicrob Agents Chemother. 2015 Nov 9. pii: AAC.01830.
    PubMed     Text format     Abstract available


  72. LEE H, Jeong BH, Park HY, Jeon K, et al
    Treatment Outcomes of Fluoroquinolone-Containing Regimens for Isoniazid-Resistant Pulmonary Tuberculosis.
    Antimicrob Agents Chemother. 2015 Nov 2. pii: AAC.01377.
    PubMed     Text format     Abstract available


  73. ZHANG D, Wang Y, Lu J, Pang Y, et al
    In vitro activity of beta-lactams in combination with beta-lactamase inhibitors against multidrug-resistant Mycobacterium tuberculosis isolates.
    Antimicrob Agents Chemother. 2015 Nov 2. pii: AAC.01035.
    PubMed     Text format     Abstract available


    October 2015
  74. SORRENTINO F, Gonzalez Del Rio R, Zheng X, Presa JM, et al
    Development of an intracellular screen for new compounds able to inhibit Mycobacterium tuberculosis growth in human macrophages.
    Antimicrob Agents Chemother. 2015 Oct 26. pii: AAC.01920.
    PubMed     Text format     Abstract available


  75. TASNEEN R, Betoudji F, Tyagi S, Li SY, et al
    Contribution of oxazolidinones to the efficacy of novel regimens containing bedaquiline and pretomanid in a mouse model of tuberculosis.
    Antimicrob Agents Chemother. 2015 Oct 26. pii: AAC.01691.
    PubMed     Text format     Abstract available


  76. HENNIG S, Naiker S, Reddy T, Egan D, et al
    The effect of SLCO1B1 polymorphisms on the pharmacokinetics of rifabutin in African HIV-infected patients with tuberculosis.
    Antimicrob Agents Chemother. 2015 Oct 19. pii: AAC.01195.
    PubMed     Text format     Abstract available


  77. PARK JS, Lee JY, Lee YJ, Kim SJ, et al
    Serum levels of anti-tuberculosis drugs and their effect on tuberculosis treatment outcome.
    Antimicrob Agents Chemother. 2015 Oct 12. pii: AAC.00693.
    PubMed     Text format     Abstract available


  78. MEDELLIN-GARIBAY SE, Cortez-Espinosa N, Milan-Segovia RC, Magana-Aquino M, et al
    CLINICAL PHARMACOKINETICS OF RIFAMPICIN IN PATIENTS WITH TUBERCULOSIS AND TYPE 2 DIABETES MELLITUS: ASSOCIATION WITH BIOCHEMICAL AND IMMUNOLOGICAL PARAMETERS.
    Antimicrob Agents Chemother. 2015 Oct 5. pii: AAC.01067.
    PubMed     Text format     Abstract available


  79. PIRES D, Valente E, Simoes MF, Carmo N, et al
    Esters of pyrazinoic acid are active against pyrazinamide-resistant strains of Mycobacterium tuberculosis and other naturally resistant mycobacteria in vitro and ex vivo within macrophages.
    Antimicrob Agents Chemother. 2015 Oct 5. pii: AAC.00936.
    PubMed     Text format     Abstract available


  80. MAIGA MC, Ahmadou Ahidjo B, Maiga M, Bishai WR, et al
    Roflumilast, a type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis.
    Antimicrob Agents Chemother. 2015 Oct 5. pii: AAC.02145.
    PubMed     Text format     Abstract available


    September 2015
  81. RUEDA J, Realpe T, Mejia GI, Zapata E, et al
    Genotypic analysis of genes associated with independent and cross-resistance to Isoniazid and Ethionamide in M. tuberculosis clinical isolates.
    Antimicrob Agents Chemother. 2015 Sep 14. pii: AAC.01028.
    PubMed     Text format     Abstract available


  82. PETERSON ND, Rosen BC, Dillon NA, Baughn AD, et al
    Uncoupling environmental pH and intrabacterial acidification from pyrazinamide susceptibility in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2015 Sep 14. pii: AAC.00967.
    PubMed     Text format     Abstract available


    August 2015
  83. HEYSELL SK, Pholwat S, Mpagama SG, Pazia SJ, et al
    Sensititre MYCOTB plate compared to Bactec MGIT 960 for first and second-line anti-tuberculosis drug susceptibility testing in Tanzania: a call to operationalize minimum inhibitory concentrations.
    Antimicrob Agents Chemother. 2015 Aug 24. pii: AAC.01117.
    PubMed     Text format     Abstract available


  84. WINGLEE K, Lun S, Pieroni M, Kozikowski A, et al
    Mutation of Rv2887, a marR-like gene, confers Mycobacterium tuberculosis resistance to an imidazopyridine-based agent.
    Antimicrob Agents Chemother. 2015 Aug 24. pii: AAC.01341.
    PubMed     Text format     Abstract available


  85. KAUSHIK A, Makkar N, Pandey P, Parrish N, et al
    Carbapenems and Rifampicin Exhibit Synergy against Mycobacterium tuberculosis and Mycobacterium abscessus.
    Antimicrob Agents Chemother. 2015 Aug 10. pii: AAC.01158.
    PubMed     Text format     Abstract available


  86. GOLD B, Roberts J, Ling Y, Lopez Quezada L, et al
    Rapid, semi-quantitative assay to discriminate among compounds with activity against replicating or non-replicating Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2015 Aug 3. pii: AAC.00803.
    PubMed     Text format     Abstract available


    July 2015
  87. VAN OOSTERHOUT JJ, Dzinjalamala FK, Dimba A, Waterhouse D, et al
    Pharmacokinetics of anti-tuberculosis drugs in HIV-positive and HIV-negative adults in Malawi.
    Antimicrob Agents Chemother. 2015 Jul 27. pii: AAC.01193.
    PubMed     Text format     Abstract available


  88. MODONGO C, Pasipanodya JG, Zetola NM, Williams SM, et al
    Amikacin concentrations predictive of ototoxicity in multidrug-resistant tuberculosis patients.
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  89. VERDUGO D, Fallows D, Ahuja S, Schluger N, et al
    Epidemiologic correlates of pyrazinamide resistant Mycobacterium tuberculosis in New York City.
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  90. GARCIA-PRATS AJ, Draper HR, Thee S, Dooley KE, et al
    The pharmacokinetics and safety of ofloxacin in children with drug-resistant tuberculosis.
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  91. OGWANG S, Good C, Okware B, Nsereko M, et al
    Sulfamethoxazole Susceptibility of Mycobacterium tuberculosis Isolates from HIV-infected Ugandan Adults with Tuberculosis Taking Trimethoprim-Sulfamethoxazole Prophylaxis.
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  92. DEMARCO VP, Ordonez AA, Klunk M, Prideaux B, et al
    Determination of 11C-Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice Using Dynamic Positron Emission Tomography Bioimaging.
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  93. SOROKA D, Li de la Sierra-Gallay I, Dubee V, Triboulet S, et al
    Hydrolysis of clavulanate by Mycobacterium tuberculosis beta-lactamase BlaC harboring a canonic SDN motif.
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  94. SINGH R, Ramachandran V, Shandil R, Sharma S, et al
    In silico based high through put screen for discovery of novel combinations for the treatment for tuberculosis.
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    June 2015
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    Mutation at embB 306, a potential marker for the identification of multidrug resistance associated with ethambutol in Mycobacterium tuberculosis.
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  96. WILLBY M, Sikes RD, Malik S, Metchock B, et al
    Correlation between GyrA mutations and ofloxacin, levofloxacin and moxifloxacin cross-resistance in Mycobacterium tuberculosis.
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  97. HAVER HL, Chua A, Ghode P, Lakshminarayana SB, et al
    Mutations in the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro selected PA-824 mutants of Mycobacterium tuberculosis.
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  98. RAMIREZ-BUSBY SM, Valafar F
    A Systematic Review of Mutations in Pyrazinamidase Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis Clinical Isolates.
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  99. STURKENBOOM MG, Mulder LW, de Jager A, van Altena R, et al
    Pharmacokinetic Modeling and Optimal Sampling Strategies for Therapeutic Drug Monitoring of Rifampin in Patients with Tuberculosis.
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  100. DALECKI AG, Haeili M, Shah S, Speer A, et al
    Disulfiram and copper ions kill Mycobacterium tuberculosis in a synergistic manner.
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  101. BROSSIER F, Sougakoff W, Bernard C, Petrou M, et al
    Molecular analysis of the embCAB locus and embR gene involved in resistance to ethambutol in clinical isolates of Mycobacterium tuberculosis in France.
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  102. MINATO Y, Thiede JM, Kordus SL, McKlveen EJ, et al
    Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance.
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    May 2015
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    Insight into the mode of action of clofazimine and combination therapy with benzothiazinones against Mycobacterium tuberculosis.
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  104. PARK SI, Oh J, Jang K, Yoon J, et al
    Pharmacokinetics of Second-line Anti-Tuberculosis Drugs after Multiple Administrations in Healthy Volunteers.
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  105. MAKAROV V, Neres J, Hartkoorn RC, Ryabova OB, et al
    8-Pyrrole-benzothiazinones non-covalent inhibitors of DprE1 from Mycobacterium tuberculosis.
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  106. JOHNSON BK, Colvin CJ, Needle DB, Mba Medie F, et al
    The carbonic anhydrase inhibitor ethoxzolamide inhibits the Mycobacterium tuberculosis PhoPR regulon, Esx-1 secretion and attenuates virulence.
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  107. SY SK, de Kock L, Diacon AH, Werely CJ, et al
    N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in drug-resistant pulmonary tuberculosis patients.
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  108. KELLER PM, Homke R, Ritter C, Valsesia G, et al
    Determination of MIC Distribution and Epidemiological Cut-Off Values for Bedaquiline and Delamanid in Mycobacterium tuberculosis Using MGIT 960/TB eXiST.
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  109. VIA LE, England K, Weiner DM, Schimel D, et al
    A sterilizing tuberculosis treatment regimen is associated with faster clearance of bacteria in cavitary lesions in marmosets.
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    April 2015
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    Evaluation of moxifloxacin-containing regimens in pathologically distinct murine tuberculosis models.
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  111. VOCAT A, Hartkoorn RC, Lechartier B, Zhang M, et al
    Bioluminescence for assessing drug potency against non-replicating Mycobacterium tuberculosis.
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  112. ALSULTAN A, An G, Peloquin CA
    Limited Sampling Strategy and Target Attainment Analysis for Levofloxacin in Patients with Tuberculosis.
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  113. REQUENA-MENDEZ A, Davies G, Moore DA
    Reply to "adequate design of pharmacokinetic-pharmacodynamic studies will help optimize tuberculosis treatment for the future".
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  114. STURKENBOOM MG, Akkerman OW, Bolhuis MS, de Lange WC, et al
    Adequate design of pharmacokinetic-pharmacodynamic studies will help optimize tuberculosis treatment for the future.
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    March 2015
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    Meropenem-clavulanic acid has high in vitro activity against multidrug-resistant Mycobacterium tuberculosis.
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  116. DOOLEY KE, Savic R, Park JG, Cramer Y, et al
    Novel dosing strategies increase exposures of the potent anti-tuberculosis drug rifapentine but are poorly tolerated in healthy volunteers: AIDS Clinical Trials Group Study A5311.
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  117. TE BRAKE LH, Ruslami R, Later-Nijland H, Mooren F, et al
    Exposure to total and protein-unbound rifampicin is not affected by malnutrition in Indonesian tuberculosis patients.
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    Pharmacokinetics and pharmacodynamics of clofazimine in the mouse model of tuberculosis.
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    Impact of beta-lactamase inhibition on the activity of ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus.
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  121. LANOIX JP, Betoudji F, Nuermberger E
    Correction for lanoix et Al., novel regimens identified in mice for treatment of latent tuberculosis infection in contacts of patients with multidrug-resistant tuberculosis.
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    February 2015
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    Tuberculous spondylitis in Russia and prominent role of multidrug-resistant clone Mycobacterium tuberculosis Beijing B0/W148.
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    The Mycobacterium tuberculosis outer membrane channel protein CpnT confers susceptibility to toxic molecules.
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  124. GUMBO T, Pasipanodya JG, Wash P, Burger A, et al
    Reply to "breakpoints and drug exposure are inevitably closely linked".
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  125. ALFFENAAR JW, Akkerman OW, Bolhuis MS, Boeree MJ, et al
    Breakpoints and drug exposure are inevitably closely linked.
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    January 2015
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    Analysis of embCAB mutations associated with ethambutol resistance in multidrug-resistant Mycobacterium tuberculosis isolates from China.
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    Mycobacterium tuberculosis Gyrase Inhibitors (MGI) as a New Class of Antitubercular Drugs.
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    Phenotypic and Genotypic Characterization of Pyrazinamide Resistance among Multidrug-resistant Tuberculosis isolates in Zhejiang, China.
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    December 2014
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    Molecular analysis of codon 548 in the rpoB gene involved in Mycobacterium tuberculosis resistance to rifampicin.
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    Molecular diagnosis of fluoroquinolone resistance in Mycobacterium tuberculosis: opening Pandora's Box.
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    Targeting Mycobacterium tuberculosis topoisomerase I by small molecule inhibitors.
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    A Novel Inhibitor of Gyrase B is a Potent Drug Candidate for the Treatment of Tuberculosis and Non-Tuberculosis Mycobacteria.
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    Pharmacokinetics of first-line anti-TB drugs in HIV-infected children with TB treated with intermittent regimens in India.
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    November 2014
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    The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo.
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    Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem, an Orally Bioavailable beta-lactam Antibiotic.
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    Genetic Determinants Involved in p-Aminosalicylic Acid Resistance in Clinical Isolates from Tuberculosis Patients in North of China during 2006-2012.
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  137. ORDONEZ AA, Pokkali S, DeMarco VP, Klunk M, et al
    Radioiodo-DPA-713 Imaging Correlates with Bactericidal Activity of Tuberculosis Treatments in Mice.
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  138. WANG F, Shao L, Fan X, Shen Y, et al
    Evolution and Transmission Patterns of Extensively Drug-Resistant Tuberculosis in China.
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  139. REEVES AZ, Campbell PJ, Willby MJ, Posey JE, et al
    Disparities in capreomycin resistance levels associated with the rrs A1401G mutation in clinical isolates of Mycobacterium tuberculosis.
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  140. ORDAS A, Raterink RJ, Jansen HJ, Cunningham F, et al
    Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen.
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    Evaluation of Pyrosequencing for Detecting Extensively Drug-resistant Tuberculosis (XDR-TB) in Clinical Isolates from Four High-burden Countries.
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  142. MULVEY MC, Lemmon M, Rotter S, Lees J, et al
    Optimization of a nucleic acid-based reporter system to detect Mycobacterium tuberculosis antibiotic sensitivity.
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    September 2014
  143. REQUENA-MENDEZ A, Davies G, Waterhouse D, Ardrey A, et al
    Effect of dosage, co-morbidities and food on pharmacokinetics of isoniazid in Peruvian TB patients.
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    August 2014
  144. SVENSSON EM, Dooley KE, Karlsson MO
    Impact of lopinavir/ritonavir or nevirapine on bedaquiline exposures: potential implications for patients with TB/HIV co-infection.
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    Linezolid manifests a rapid and dramatic therapeutic effect for patients with life threatening tuberculous meningitis.
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    February 2014
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    The pharmacokinetics of isoniazid in low birth weight and premature infants.
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