Abstract
Reactivation of hepatitis B virus infection in patients with resolved infection is rare and is usually associated with immunosuppressive therapy. Morbidity and mortality are high. Some cases of hepatitis B reactivation associated with the use of rituximab have previously been published. We present the case of a patient with B-cell non-Hodgkin lymphoma receiving combination chemotherapy with rituximab who showed hepatitis B reactivation followed by liver failure. The most recent literature on this topic is reviewed and discussed.
Publication types
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Case Reports
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English Abstract
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Review
MeSH terms
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Adenine / analogs & derivatives
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Adenine / therapeutic use
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Aged, 80 and over
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / adverse effects*
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Antibodies, Monoclonal, Murine-Derived
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Antibody Specificity
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Comorbidity
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Cyclophosphamide / administration & dosage
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Fatal Outcome
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Hepatitis B Antibodies / blood*
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Hepatitis B Antibodies / immunology
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Hepatitis B Core Antigens / immunology*
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Hepatitis B Surface Antigens / blood
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Hepatitis B virus / physiology*
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Hepatitis B, Chronic / complications*
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Hepatitis B, Chronic / drug therapy
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Hepatitis B, Chronic / virology
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Humans
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Immunologic Factors / administration & dosage
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Immunologic Factors / adverse effects*
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Immunotherapy / adverse effects*
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Liver Failure / etiology
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Lymphoma, B-Cell, Marginal Zone / complications*
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Lymphoma, B-Cell, Marginal Zone / drug therapy
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Male
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Organophosphonates / therapeutic use
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Prednisone / administration & dosage
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Recurrence
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Rituximab
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Tenofovir
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Vincristine / administration & dosage
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Virus Activation / drug effects*
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Virus Activation / immunology*
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Murine-Derived
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Hepatitis B Antibodies
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Hepatitis B Core Antigens
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Hepatitis B Surface Antigens
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Immunologic Factors
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Organophosphonates
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Rituximab
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Vincristine
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Cyclophosphamide
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Tenofovir
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Adenine
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Prednisone