Abstract
We describe the first confirmed person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus that occurred in a hematology unit in the United Kingdom. Eleven cases of (H1N1) 2009 virus infection were identified, of which, ten were related as shown by sequence analysis of the hemagglutinin and neuraminidase genes. H275Y analysis demonstrated that 8 of 10 case patients had oseltamivir-resistant virus, with 4 of 8 case patients infected by direct transmission of resistant virus. Zanamivir should be considered as first-line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influenza vaccination encouraged to further reduce the number of susceptible individuals.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Aged
-
Amino Acid Substitution / genetics
-
Antiviral Agents / pharmacology*
-
Cross Infection / transmission
-
Cross Infection / virology
-
Drug Resistance, Viral*
-
Hemagglutinins, Viral / genetics
-
Hospitals
-
Humans
-
Influenza A Virus, H1N1 Subtype / drug effects*
-
Influenza A Virus, H1N1 Subtype / isolation & purification
-
Influenza, Human / transmission*
-
Influenza, Human / virology*
-
Lymphopenia / complications
-
Middle Aged
-
Mutation, Missense
-
Neuraminidase / genetics
-
Oseltamivir / pharmacology*
-
RNA, Viral / genetics
-
Sequence Analysis, DNA
-
United Kingdom
-
Viral Proteins / genetics
Substances
-
Antiviral Agents
-
Hemagglutinins, Viral
-
RNA, Viral
-
Viral Proteins
-
hemagglutinin fusogenic peptide, influenza virus
-
Oseltamivir
-
NA protein, influenza A virus
-
Neuraminidase