Delayed focal lipoatrophy after AS03-adjuvanted influenza A (H1N1) 2009 vaccine

Emilie Javelle; Benjamin Soulier; Christian Brosset; Solène Lorcy; Fabrice Simon

doi:10.1016/j.vaccine.2010.12.018

Delayed focal lipoatrophy after AS03-adjuvanted influenza A (H1N1) 2009 vaccine

Vaccine. 2011 Feb 1;29(6):1123-5. doi: 10.1016/j.vaccine.2010.12.018. Epub 2010 Dec 18.

Authors

Emilie Javelle¹, Benjamin Soulier, Christian Brosset, Solène Lorcy, Fabrice Simon

Affiliation

¹ Department of Infectious Diseases and Tropical Medicine, Laveran Military Teaching Hospital, Marseille Cedex 13, France.

PMID: 21172376
DOI: 10.1016/j.vaccine.2010.12.018

Abstract

Intramuscular vaccination may lead to loss of subcutaneous fat resulting in skin depression at the site of injection. We report for the first time a delayed lipoatrophy after with AS03-adjuvanted influenza A (H1N1) 2009 vaccine. Inadequate administration into the adipose tissue may be causative. During next pandemic, education to optimal intramuscular administration and prolonged monitoring of adverse effects could be proposed.

Publication types

Case Reports

MeSH terms

Adult
Drug Combinations
Female
Humans
Influenza A Virus, H1N1 Subtype / immunology*
Influenza Vaccines / administration & dosage
Influenza Vaccines / adverse effects*
Injections, Intramuscular
Lipodystrophy / chemically induced*
Lipodystrophy / pathology
Polysorbates / administration & dosage
Polysorbates / adverse effects*
Skin Diseases / chemically induced*
Skin Diseases / pathology
Squalene / administration & dosage
Squalene / adverse effects*
Subcutaneous Tissue / pathology
alpha-Tocopherol / administration & dosage
alpha-Tocopherol / adverse effects*

Substances

Drug Combinations
Influenza Vaccines
Polysorbates
Squalene
AS03 adjuvant
alpha-Tocopherol