Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN

Vaccine. 2011 Feb 11;29(8):1657-65. doi: 10.1016/j.vaccine.2010.12.046. Epub 2010 Dec 30.

Abstract

Influenza virosomes are virus-like particles, representing a platform for vaccine development. In this study, we examined the immunogenicity of avian influenza virosomes with or without inclusion of recombinant chicken interferon-gamma (rChIFN-γ) or CpG-ODN in chickens. Immunization with virosomes adjuvanted with CpG-ODN elicited the highest haemagglutination inhibition antibody titres, as well as IgG and IgA serum antibody responses. Moreover, Virosomes+CpG-ODN formulation induced an antigen-specific spleen cell proliferation and IFN-γ expression. In conclusion, our results demonstrated that virus-specific antibody- and cell-mediated responses may be induced in chickens immunized with virosomes and these responses can be enhanced by incorporating CpG-ODN in the virosome vaccine formulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Antibodies, Neutralizing / blood
  • Antibodies, Viral / blood
  • Antibody Formation
  • Chickens / immunology
  • Cross Reactions / immunology
  • Hemagglutination Inhibition Tests
  • Immunity, Cellular
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Influenza Vaccines / immunology*
  • Influenza in Birds / immunology
  • Influenza in Birds / prevention & control*
  • Interferon-gamma / immunology
  • Oligodeoxyribonucleotides / pharmacology*
  • Poultry Diseases / immunology
  • Poultry Diseases / prevention & control
  • Recombinant Proteins
  • Spleen / cytology
  • Spleen / immunology
  • Vaccines, Virosome / immunology

Substances

  • Adjuvants, Immunologic
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • CPG-oligonucleotide
  • Immunoglobulin A
  • Immunoglobulin G
  • Influenza Vaccines
  • Oligodeoxyribonucleotides
  • Recombinant Proteins
  • Vaccines, Virosome
  • Interferon-gamma