Antigenic stability of H1N1 pandemic vaccines correlates with vaccine strain

Aaron Farnsworth; Terry D Cyr; Changgui Li; Junzhi Wang; Xuguang Li

doi:10.1016/j.vaccine.2010.12.120

Antigenic stability of H1N1 pandemic vaccines correlates with vaccine strain

Vaccine. 2011 Feb 11;29(8):1529-33. doi: 10.1016/j.vaccine.2010.12.120. Epub 2011 Jan 4.

Authors

Aaron Farnsworth¹, Terry D Cyr, Changgui Li, Junzhi Wang, Xuguang Li

Affiliation

¹ Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Canada. aaron.farnsworth@hc-sc.gc.ca

PMID: 21211583
DOI: 10.1016/j.vaccine.2010.12.120

Abstract

In 2009 a novel H1N1 influenza virus emerged and spread rapidly. Soon after vaccine lots were released, however, the shelf life was revised downward due to an unexpected decrease in HA potency. In this study, we found differences in both stability and antigenic content of two monovalent H1N1/2009 vaccine preparations. These appear to have arisen due to differences in the A/California/7/2009-like influenza strain used to prepare vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Viral / chemistry*
Antigens, Viral / immunology
Chickens
Drug Stability
Hemagglutinin Glycoproteins, Influenza Virus / chemistry*
Hemagglutinin Glycoproteins, Influenza Virus / immunology
Humans
Influenza A Virus, H1N1 Subtype / immunology*
Influenza Vaccines / chemistry*
Influenza Vaccines / immunology
Influenza, Human / prevention & control
Protein Stability
Protein Structure, Secondary
Reassortant Viruses / immunology

Substances

Antigens, Viral
Hemagglutinin Glycoproteins, Influenza Virus
Influenza Vaccines