Local innate and adaptive immune responses regulate inflammatory cell influx into the lungs after vaccination with formalin inactivated RSV

Vaccine. 2011 Mar 24;29(15):2730-41. doi: 10.1016/j.vaccine.2011.01.087. Epub 2011 Feb 19.

Abstract

Inactivated respiratory syncytial virus (RSV) vaccines tend to predispose for immune mediated enhanced disease, characterized by Th2 responses and airway hypersensitivity reactions. We show in a C57BL/6 mouse model that the early innate response elicited by the challenge virus (RSV versus influenza virus) influences the outcome of the Th1/Th2 balance in the lung after intramuscular priming with inactivated vaccine. Priming of CD4(+)/IFN-γ(+) T cells by mature dendritic cells administered intravenously and/or priming of a virus specific CD8(+) T cell response ameliorated the Th2-mediated inflammatory response in the lung, suggesting that vaccination procedures are feasible that prevent vaccine induced immune pathology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptive Immunity
  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Dendritic Cells / immunology
  • Immunity, Innate
  • Lung / immunology*
  • Mice
  • Mice, Inbred C57BL
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / pathology
  • Respiratory Syncytial Virus Vaccines / immunology*
  • Respiratory Syncytial Viruses / immunology*
  • Th2 Cells / immunology
  • Vaccines, Inactivated / immunology

Substances

  • Respiratory Syncytial Virus Vaccines
  • Vaccines, Inactivated