Abstract
The majority of human infections associated with H7 influenza viruses have resulted in ocular and not respiratory disease. While oseltamivir has been prescribed to individuals presenting with conjunctivitis following H7 virus exposure, it is unknown if oseltamivir inhibits virus replication in ocular tissue. We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues.
MeSH terms
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Animals
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Antiviral Agents / pharmacology*
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Conjunctivitis / drug therapy
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Conjunctivitis / virology*
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Eye / drug effects
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Eye / virology
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Humans
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Influenza A Virus, H7N3 Subtype / drug effects*
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Influenza A Virus, H7N3 Subtype / physiology
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Influenza A Virus, H7N7 Subtype / drug effects*
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Influenza A Virus, H7N7 Subtype / physiology
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Influenza, Human / virology
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Injections, Intraocular
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Mice
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Mice, Inbred BALB C
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Neuraminidase / antagonists & inhibitors
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Neuraminidase / metabolism
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Orthomyxoviridae Infections / drug therapy
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Orthomyxoviridae Infections / virology*
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Oseltamivir / pharmacology*
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Viral Proteins / antagonists & inhibitors
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Viral Proteins / metabolism
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Virus Replication / drug effects
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Vision, Ocular / drug effects
Substances
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Antiviral Agents
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Viral Proteins
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Oseltamivir
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Neuraminidase