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  Alzheimer's Disease

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Articles published in Acta Neuropathol

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Single Articles


    November 2025
  1. PHUONG HT, Tomas RF, Akmese C, Mijares A, et al
    PolyGR-containing aggregates link with pathology and clinical features of Alzheimer's disease.
    Acta Neuropathol. 2025;150:49.
    PubMed     Abstract available


    October 2025
  2. NEUBAUER A, Weissenbrunner D, Pekrun S, Roeber S, et al
    Alpha-synuclein deposition patterns in Alzheimer's disease: association with cortical amyloid beta and variable tau load.
    Acta Neuropathol. 2025;150:46.
    PubMed     Abstract available


  3. ZHANG Z, Capuano AW, Beadell A, Tasaki S, et al
    Brain-derived 5-hydroxymethylcytosine epigenetic scores are related to Alzheimer's disease pathology and cognitive decline.
    Acta Neuropathol. 2025;150:45.
    PubMed     Abstract available


  4. AUGUR ZM, Fogo GM, Arbery MR, Hsieh YC, et al
    Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis.
    Acta Neuropathol. 2025;150:43.
    PubMed     Abstract available


  5. INOUE Y, Wang H, Heckman MG, Ren Y, et al
    Impact of APOE on cerebrovascular lipid profile in Alzheimer's disease.
    Acta Neuropathol. 2025;150:39.
    PubMed     Abstract available


    September 2025
  6. VAN WETERING J, Deshayes NAC, Boone J, Rodrigues Fernandes I, et al
    Limbic Alzheimer's co-pathology in multiple system atrophy is associated with cognitive impairment and diagnostic inaccuracy.
    Acta Neuropathol. 2025;150:30.
    PubMed     Abstract available


  7. TOME SO, Gawor K, Ospitalieri S, Ronisz A, et al
    Differences and overlaps in TDP-43 pathology of 'pure' LATE-NC compared to LATE-NC coexisting with Alzheimer's disease.
    Acta Neuropathol. 2025;150:28.
    PubMed     Abstract available


  8. OGG J, Postupna N, Gibbons LE, Ariza J, et al
    Down syndrome and a presenilin 2 variant: dual genetic risk of Alzheimer's disease.
    Acta Neuropathol. 2025;150:24.
    PubMed     Abstract available


    August 2025
  9. NELSON PT, Crary JF
    PART and amyloid cascade hypotheses are alive and well (but are not so simple). Scientific commentary on: "Sequence and trajectory of early Alzheimer's disease-related tau inclusions in the hippocampal formation of cases without amyloid-beta deposits"
    Acta Neuropathol. 2025;150:14.
    PubMed    


    July 2025
  10. MUKHERJEE S, Coyle R, Dubois C, Perez K, et al
    Isomerized Abeta in the brain can distinguish the status of amyloidosis in the Alzheimer's disease spectrum.
    Acta Neuropathol. 2025;150:7.
    PubMed     Abstract available


  11. MARTINEZ-PEREZ DA, McGlothan JL, Rodichkin AN, Abilmouna K, et al
    Amyloid-beta plaque-associated microglia drive TSPO upregulation in Alzheimer's disease.
    Acta Neuropathol. 2025;150:6.
    PubMed     Abstract available


    June 2025
  12. DOURTE M, Paitre E, Bouchoucha M, Boyer E, et al
    The olfactory epithelium: a critical gateway for pathological tau propagation and a target for mitigating tauopathy in the central nervous system.
    Acta Neuropathol. 2025;149:64.
    PubMed     Abstract available


  13. CHEN CD, Franklin EE, Li Y, Joseph-Mathurin N, et al
    Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease.
    Acta Neuropathol. 2025;149:57.
    PubMed     Abstract available


  14. ONDREJCAK T, Hu NW, Coode E, Campbell T, et al
    Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region.
    Acta Neuropathol. 2025;149:56.
    PubMed     Abstract available


  15. LIAO F, Calvo-Rodriguez M, Chhaya M, Sefrin JP, et al
    Anti-pyroglutamate-3 Abeta immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Abeta amyloidosis.
    Acta Neuropathol. 2025;149:55.
    PubMed     Abstract available


    May 2025
  16. SADLEIR KR, Gomez KP, Edwards AE, Patel AJ, et al
    Annexin A6 membrane repair protein protects against amyloid-induced dystrophic neurites and tau phosphorylation in Alzheimer's disease model mice.
    Acta Neuropathol. 2025;149:51.
    PubMed     Abstract available


  17. BRAAK H, Mayer B, Feldengut S, Schon M, et al
    Sequence and trajectory of early Alzheimer's disease-related tau inclusions in the hippocampal formation of cases without amyloid-beta deposits.
    Acta Neuropathol. 2025;149:50.
    PubMed     Abstract available


  18. FARRELL C, Buhidma Y, Mumford P, Heywood WE, et al
    Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease.
    Acta Neuropathol. 2025;149:49.
    PubMed     Abstract available


  19. KAVANAGH T, Thierry M, Balcomb K, Ponce J, et al
    The interactome of tau phosphorylated at T217 in Alzheimer's disease human brain tissue.
    Acta Neuropathol. 2025;149:44.
    PubMed     Abstract available


    April 2025
  20. LANTERO-RODRIGUEZ J, Montoliu-Gaya L, Benedet AL, Vrillon A, et al
    Correction: CSF p-tau205: a biomarker of tau pathology in Alzheimer's disease.
    Acta Neuropathol. 2025;149:34.
    PubMed    


  21. FELEKE R, Jogaudaite S, Velentza-Almpani E, Yeung-Yeung L, et al
    Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures.
    Acta Neuropathol. 2025;149:31.
    PubMed     Abstract available


    March 2025
  22. LANTERO-RODRIGUEZ J, Montoliu-Gaya L, Ashton NJ, Pola I, et al
    Biofluid-based staging of Alzheimer's disease.
    Acta Neuropathol. 2025;149:27.
    PubMed     Abstract available


  23. GHATAMANENI S, Hruska C, Shin I, Bruinsma T, et al
    High resolution autoradiography of [(18)F]MK-6240 and [(18)F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity.
    Acta Neuropathol. 2025;149:26.
    PubMed     Abstract available


    February 2025
  24. EBNER BA, Erdahl SA, Lundgreen CS, Vassilaki M, et al
    Brain tissue metal concentrations and Alzheimer's disease neuropathology in total joint arthroplasty patients versus controls.
    Acta Neuropathol. 2025;149:18.
    PubMed     Abstract available


  25. FIXEMER S, Miranda de la Maza M, Hammer GP, Jeannelle F, et al
    Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus.
    Acta Neuropathol. 2025;149:19.
    PubMed     Abstract available


    January 2025
  26. MARTA-ARIZA M, Leitner DF, Kanshin E, Suazo J, et al
    Comparison of the amyloid plaque proteome in Down syndrome, early-onset Alzheimer's disease, and late-onset Alzheimer's disease.
    Acta Neuropathol. 2025;149:9.
    PubMed     Abstract available


  27. SAEZ-CALVERAS N, Vaquer-Alicea J, White CL 3rd, Tak Y, et al
    Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy.
    Acta Neuropathol. 2025;149:6.
    PubMed     Abstract available


    December 2024
  28. MOONEN S, Koper MJ, Van Schoor E, Schaeverbeke JM, et al
    Correction: Pyroptosis in Alzheimer's disease: cell type?specific activation in microglia, astrocytes and neurons.
    Acta Neuropathol. 2024;149:3.
    PubMed    


  29. KADAMANGUDI S, Marcatti M, Zhang WR, Fracassi A, et al
    Amyloid-beta oligomers increase the binding and internalization of tau oligomers in human synapses.
    Acta Neuropathol. 2024;149:2.
    PubMed     Abstract available


  30. SCHREMPEL S, Kottwitz AK, Piechotta A, Gnoth K, et al
    Identification of isoAsp7-Abeta as a major Abeta variant in Alzheimer's disease, dementia with Lewy bodies and vascular dementia.
    Acta Neuropathol. 2024;148:78.
    PubMed     Abstract available


    November 2024
  31. ROY N, Haq I, Ngo JC, Bennett DA, et al
    Elevated expression of the retrotransposon LINE-1 drives Alzheimer's disease-associated microglial dysfunction.
    Acta Neuropathol. 2024;148:75.
    PubMed     Abstract available


  32. BALCOMB K, Johnston C, Kavanagh T, Leitner D, et al
    SMOC1 colocalizes with Alzheimer's disease neuropathology and delays Abeta aggregation.
    Acta Neuropathol. 2024;148:72.
    PubMed     Abstract available


  33. PHILLIPS JM, Winfree RL, Seto M, Schneider JA, et al
    Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer's disease.
    Acta Neuropathol. 2024;148:69.
    PubMed     Abstract available


  34. KATSUMATA Y, Wu X, Aung KZ, Fardo DW, et al
    Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer's pathologies.
    Acta Neuropathol. 2024;148:66.
    PubMed     Abstract available


  35. GARLAND EF, Antony H, Kulagowska L, Scott T, et al
    The microglial translocator protein (TSPO) in Alzheimer's disease reflects a phagocytic phenotype.
    Acta Neuropathol. 2024;148:62.
    PubMed     Abstract available


    October 2024
  36. VATTATHIL SM, Tan SSM, Kim PJ, Bennett DA, et al
    Effects of brain microRNAs in cognitive trajectory and Alzheimer's disease.
    Acta Neuropathol. 2024;148:59.
    PubMed     Abstract available


  37. SHANAKI BAVARSAD M, Spina S, Oehler A, Allen IE, et al
    Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation.
    Acta Neuropathol. 2024;148:58.
    PubMed     Abstract available


  38. WANG YR, Zeng XQ, Wang J, Fowler CJ, et al
    Autoantibodies to BACE1 promote Abeta accumulation and neurodegeneration in Alzheimer's disease.
    Acta Neuropathol. 2024;148:57.
    PubMed     Abstract available


  39. LAUREYSSEN C, Kucukali F, Van Dongen J, Gawor K, et al
    Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer's-type dementia.
    Acta Neuropathol. 2024;148:55.
    PubMed     Abstract available


    September 2024
  40. GIONG HK, Hyeon SJ, Lee JG, Cho HJ, et al
    Tau accumulation is cleared by the induced expression of VCP via autophagy.
    Acta Neuropathol. 2024;148:46.
    PubMed     Abstract available


  41. FREIBURGHAUS T, Pawlik D, Oliveira Hauer K, Ossenkoppele R, et al
    Association of in vivo retention of [(18)f] flortaucipir pet with tau neuropathology in corresponding brain regions.
    Acta Neuropathol. 2024;148:44.
    PubMed     Abstract available


  42. DENNING AE, Ittyerah R, Levorse LM, Sadeghpour N, et al
    Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer's disease continuum.
    Acta Neuropathol. 2024;148:37.
    PubMed     Abstract available


    August 2024
  43. SCHRODER S, Fuchs U, Gisa V, Pena T, et al
    PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease.
    Acta Neuropathol. 2024;148:32.
    PubMed     Abstract available


  44. BOTELLA LUCENA P, Heneka MT
    Inflammatory aspects of Alzheimer's disease.
    Acta Neuropathol. 2024;148:31.
    PubMed     Abstract available


  45. MA Y, Reyes-Dumeyer D, Piriz A, Recio P, et al
    Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups.
    Acta Neuropathol. 2024;148:27.
    PubMed     Abstract available


  46. HART DE RUYTER FJ, Evers MJAP, Morrema THJ, Dijkstra AA, et al
    Neuropathological hallmarks in the post-mortem retina of neurodegenerative diseases.
    Acta Neuropathol. 2024;148:24.
    PubMed     Abstract available


  47. HOQ MR, Fernandez A, Vago FS, Hallinan GI, et al
    Cryo-EM structures of cotton wool plaques' amyloid beta and of tau filaments in dominantly inherited Alzheimer disease.
    Acta Neuropathol. 2024;148:20.
    PubMed     Abstract available


  48. JURY-GARFE N, Redding-Ochoa J, You Y, Martinez P, et al
    Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer's disease.
    Acta Neuropathol. 2024;148:15.
    PubMed     Abstract available


    July 2024
  49. LEITNER D, Kavanagh T, Kanshin E, Balcomb K, et al
    Differences in the cerebral amyloid angiopathy proteome in Alzheimer's disease and mild cognitive impairment.
    Acta Neuropathol. 2024;148:9.
    PubMed     Abstract available


  50. KASRI A, Camporesi E, Gkanatsiou E, Boluda S, et al
    Amyloid-beta peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer's disease with APPdup and Down syndrome.
    Acta Neuropathol. 2024;148:8.
    PubMed     Abstract available


  51. SHI H, Mirzaei N, Koronyo Y, Davis MR, et al
    Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status.
    Acta Neuropathol. 2024;148:3.
    PubMed     Abstract available


    June 2024
  52. QU W, Lam M, McInvale JJ, Mares JA, et al
    Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APP(V717I) mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator.
    Acta Neuropathol. 2024;147:107.
    PubMed     Abstract available


  53. OLLEN-BITTLE N, Pejhan S, Pasternak SH, Keene CD, et al
    Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer's disease.
    Acta Neuropathol. 2024;147:105.
    PubMed     Abstract available


  54. WOODWORTH DC, Nguyen KM, Sordo L, Scambray KA, et al
    Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer's Coordinating Center database.
    Acta Neuropathol. 2024;147:103.
    PubMed     Abstract available


  55. HOGLUND Z, Ruiz-Uribe N, Del Sastre E, Woost B, et al
    Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease.
    Acta Neuropathol. 2024;147:101.
    PubMed     Abstract available


  56. SARKANY B, David C, Hortobagyi T, Gombas P, et al
    Early and selective localization of tau filaments to glutamatergic subcellular domains within the human anterodorsal thalamus.
    Acta Neuropathol. 2024;147:98.
    PubMed     Abstract available


  57. GAO F, Zhang M, Wang Q, Ni M, et al
    Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer's disease.
    Acta Neuropathol. 2024;147:97.
    PubMed     Abstract available


  58. BALUSU S, De Strooper B
    The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disease.
    Acta Neuropathol. 2024;147:96.
    PubMed     Abstract available


  59. ANDO K, Kucukali F, Doeraene E, Nagaraj S, et al
    Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer's disease pathology progression.
    Acta Neuropathol. 2024;147:94.
    PubMed     Abstract available


    May 2024
  60. GRANHOLM AE, Englund E, Gilmore A, Head E, et al
    Neuropathological findings in Down syndrome, Alzheimer's disease and control patients with and without SARS-COV-2: preliminary findings.
    Acta Neuropathol. 2024;147:92.
    PubMed     Abstract available


  61. THIERRY M, Ponce J, Marta-Ariza M, Askenazi M, et al
    The influence of APOE(epsilon4) on the pTau interactome in sporadic Alzheimer's disease.
    Acta Neuropathol. 2024;147:91.
    PubMed     Abstract available


  62. ELLIS MJ, Lekka C, Holden KL, Tulmin H, et al
    Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry.
    Acta Neuropathol. 2024;147:87.
    PubMed     Abstract available


  63. FANCY NN, Smith AM, Caramello A, Tsartsalis S, et al
    Characterisation of premature cell senescence in Alzheimer's disease using single nuclear transcriptomics.
    Acta Neuropathol. 2024;147:78.
    PubMed     Abstract available


    April 2024
  64. BHATTARAI P, Gunasekaran TI, Belloy ME, Reyes-Dumeyer D, et al
    Rare genetic variation in fibronectin 1 (FN1) protects against APOEepsilon4 in Alzheimer's disease.
    Acta Neuropathol. 2024;147:70.
    PubMed     Abstract available


  65. THAL DR, Gawor K, Moonen S
    Regulated cell death and its role in Alzheimer's disease and amyotrophic lateral sclerosis.
    Acta Neuropathol. 2024;147:69.
    PubMed     Abstract available


  66. JAISA-AAD M, Munoz-Castro C, Healey MA, Hyman BT, et al
    Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer's disease and related dementias.
    Acta Neuropathol. 2024;147:66.
    PubMed     Abstract available


  67. WACHTER A, Woodbury ME, Lombardo S, Abdourahman A, et al
    Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Abeta and tau.
    Acta Neuropathol. 2024;147:65.
    PubMed     Abstract available


    March 2024
  68. BOUTER Y, Noguerola JSL, Tucholla P, Crespi GAN, et al
    Correction: Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncted Abeta in sporadic Alzheimer disease cases and mouse models.
    Acta Neuropathol. 2024;147:59.
    PubMed    


  69. MALDONADO-DIAZ C, Hiya S, Yokoda RT, Farrell K, et al
    Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies.
    Acta Neuropathol. 2024;147:58.
    PubMed     Abstract available


  70. XU H, Qiu Q, Hu P, Hoxha K, et al
    MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.
    Acta Neuropathol. 2024;147:55.
    PubMed     Abstract available


  71. WALTON RL, Koga S, Beasley AI, White LJ, et al
    Role of GBA variants in Lewy body disease neuropathology.
    Acta Neuropathol. 2024;147:54.
    PubMed     Abstract available


    February 2024
  72. ALEXANDER A, Alvarez VE, Huber BR, Alosco ML, et al
    Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE.
    Acta Neuropathol. 2024;147:45.
    PubMed     Abstract available


  73. MALIK N, Miah MU, Galgani A, McAleese K, et al
    Regional AT-8 reactive tau species correlate with intracellular Abeta levels in cases of low AD neuropathologic change.
    Acta Neuropathol. 2024;147:40.
    PubMed     Abstract available


  74. WU YC, Bogale TA, Koistinaho J, Pizzi M, et al
    The contribution of beta-amyloid, Tau and alpha-synuclein to blood-brain barrier damage in neurodegenerative disorders.
    Acta Neuropathol. 2024;147:39.
    PubMed     Abstract available


  75. COLOM-CADENA M, Toombs J, Simzer E, Holt K, et al
    Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease.
    Acta Neuropathol. 2024;147:32.
    PubMed     Abstract available


  76. OERTEL FC, Casillas D, Cobigo Y, Condor Montes S, et al
    Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies".
    Acta Neuropathol. 2024;147:30.
    PubMed    


  77. CHUNG M, Carter EK, Veire AM, Dammer EB, et al
    Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains.
    Acta Neuropathol. 2024;147:29.
    PubMed     Abstract available


    January 2024
  78. LEITNER D, Pires G, Kavanagh T, Kanshin E, et al
    Similar brain proteomic signatures in Alzheimer's disease and epilepsy.
    Acta Neuropathol. 2024;147:27.
    PubMed     Abstract available


  79. AGUERO C, Dhaynaut M, Amaral AC, Moon SH, et al
    Head-to-head comparison of [(18)F]-Flortaucipir, [(18)F]-MK-6240 and [(18)F]-PI-2620 postmortem binding across the spectrum of neurodegenerative diseases.
    Acta Neuropathol. 2024;147:25.
    PubMed     Abstract available


  80. FAZELI E, Child DD, Bucks SA, Stovarsky M, et al
    A familial missense variant in the Alzheimer's disease gene SORL1 impairs its maturation and endosomal sorting.
    Acta Neuropathol. 2024;147:20.
    PubMed     Abstract available


  81. VAN DER GAAG BL, Deshayes NAC, Breve JJP, Bol JGJM, et al
    Distinct tau and alpha-synuclein molecular signatures in Alzheimer's disease with and without Lewy bodies and Parkinson's disease with dementia.
    Acta Neuropathol. 2024;147:14.
    PubMed     Abstract available


  82. LANTERO-RODRIGUEZ J, Montoliu-Gaya L, Benedet AL, Vrillon A, et al
    CSF p-tau205: a biomarker of tau pathology in Alzheimer's disease.
    Acta Neuropathol. 2024;147:12.
    PubMed     Abstract available


  83. AGRA ALMEIDA QUADROS AR, Li Z, Wang X, Ndayambaje IS, et al
    Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease.
    Acta Neuropathol. 2024;147:9.
    PubMed     Abstract available


  84. TAYLOR LW, Simzer EM, Pimblett C, Lacey-Solymar OTT, et al
    p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
    Acta Neuropathol. 2024;147:7.
    PubMed     Abstract available


    December 2023
  85. MONTOLIU-GAYA L, Alosco ML, Yhang E, Tripodis Y, et al
    Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study.
    Acta Neuropathol. 2023;147:5.
    PubMed     Abstract available


  86. CHANG K, Ling JP, Redding-Ochoa J, An Y, et al
    Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer's disease neuropathologic changes and cognitive decline.
    Acta Neuropathol. 2023;147:4.
    PubMed     Abstract available


    November 2023
  87. VANDEVREDE L, La Joie R, Horiki S, Mundada NS, et al
    Co-pathology may impact outcomes of amyloid-targeting treatments: clinicopathological results from two patients treated with aducanumab.
    Acta Neuropathol. 2023;146:777-781.
    PubMed    


    September 2023
  88. SORDO L, Qian T, Bukhari SA, Nguyen KM, et al
    Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old.
    Acta Neuropathol. 2023;146:415-432.
    PubMed     Abstract available


    August 2023
  89. NGUYEN AT, Wang K, Hu G, Wang X, et al
    Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease.
    Acta Neuropathol. 2023 Aug 17. doi: 10.1007/s00401-023-02620.
    PubMed    


  90. JUDD JM, Jasbi P, Winslow W, Serrano GE, et al
    Inflammation and the pathological progression of Alzheimer's disease are associated with low circulating choline levels.
    Acta Neuropathol. 2023 Aug 7. doi: 10.1007/s00401-023-02616.
    PubMed     Abstract available


  91. MATE DE GERANDO A, Welikovitch LA, Khasnavis A, Commins C, et al
    Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau.
    Acta Neuropathol. 2023;146:191-210.
    PubMed     Abstract available


    July 2023
  92. NEUMANN M, Perneel J, Cheung S, Van den Broeck M, et al
    Limbic-predominant age-related TDP-43 proteinopathy (LATE-NC) is associated with abundant TMEM106B pathology.
    Acta Neuropathol. 2023;146:163-166.
    PubMed    


  93. YU L, Boyle PA, Janelidze S, Petyuk VA, et al
    Plasma p-tau181 and p-tau217 in discriminating PART, AD and other key neuropathologies in older adults.
    Acta Neuropathol. 2023;146:1-11.
    PubMed     Abstract available


    June 2023
  94. BERMUDEZ C, Graff-Radford J, Syrjanen JA, Stricker NH, et al
    Plasma biomarkers for prediction of Alzheimer's disease neuropathologic change.
    Acta Neuropathol. 2023 Jun 3. doi: 10.1007/s00401-023-02594.
    PubMed     Abstract available


  95. FILIPELLO F, You SF, Mirfakhar FS, Mahali S, et al
    Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
    Acta Neuropathol. 2023;145:749-772.
    PubMed     Abstract available


    May 2023
  96. MANCA M, Standke HG, Browne DF, Huntley ML, et al
    Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases.
    Acta Neuropathol. 2023 May 8. doi: 10.1007/s00401-023-02574.
    PubMed     Abstract available


  97. HOQ MR, Bharath SR, Hallinan GI, Fernandez A, et al
    Cross-beta helical filaments of Tau and TMEM106B in gray and white matter of multiple system tauopathy with presenile dementia.
    Acta Neuropathol. 2023;145:707-710.
    PubMed    


    March 2023
  98. CHENG Y, He CY, Tian DY, Chen SH, et al
    Physiological beta-amyloid clearance by the liver and its therapeutic potential for Alzheimer's disease.
    Acta Neuropathol. 2023 Mar 25. doi: 10.1007/s00401-023-02559.
    PubMed     Abstract available


  99. WINFREE RL, Seto M, Dumitrescu L, Menon V, et al
    TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia.
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