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Articles published in Acta Neuropathol

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Single Articles


    August 2018
  1. JELLINGER KA
    Different patterns of hippocampal tau pathology in Alzheimer's disease and PART.
    Acta Neuropathol. 2018 Aug 7. pii: 10.1007/s00401-018-1894.
    PubMed     Text format    


    July 2018
  2. HEINSEN H, Grinberg LT
    On the origin of tau seeding activity in Alzheimer's disease.
    Acta Neuropathol. 2018 Jul 23. pii: 10.1007/s00401-018-1890.
    PubMed     Text format    


  3. KHAN SS, LaCroix M, Boyle G, Sherman MA, et al
    Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons.
    Acta Neuropathol. 2018 Jul 11. pii: 10.1007/s00401-018-1886.
    PubMed     Text format     Abstract available


  4. DEMING Y, Dumitrescu L, Barnes LL, Thambisetty M, et al
    Sex-specific genetic predictors of Alzheimer's disease biomarkers.
    Acta Neuropathol. 2018 Jul 2. pii: 10.1007/s00401-018-1881.
    PubMed     Text format     Abstract available


  5. SARDAR SINHA M, Ansell-Schultz A, Civitelli L, Hildesjo C, et al
    Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers.
    Acta Neuropathol. 2018;136:41-56.
    PubMed     Text format     Abstract available


    June 2018
  6. ROBINSON JL, Corrada MM, Kovacs GG, Dominique M, et al
    Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study.
    Acta Neuropathol. 2018 Jun 18. pii: 10.1007/s00401-018-1872.
    PubMed     Text format     Abstract available


    May 2018
  7. MANN DMA, Davidson YS, Robinson AC, Allen N, et al
    Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease.
    Acta Neuropathol. 2018 May 16. pii: 10.1007/s00401-018-1866.
    PubMed     Text format     Abstract available


  8. KAUFMAN SK, Del Tredici K, Thomas TL, Braak H, et al
    Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART.
    Acta Neuropathol. 2018 May 11. pii: 10.1007/s00401-018-1855.
    PubMed     Text format     Abstract available


    April 2018
  9. ANDROUIN A, Potier B, Nagerl UV, Cattaert D, et al
    Evidence for altered dendritic spine compartmentalization in Alzheimer's disease and functional effects in a mouse model.
    Acta Neuropathol. 2018 Apr 25. pii: 10.1007/s00401-018-1847.
    PubMed     Text format     Abstract available


  10. HONG W, Wang Z, Liu W, O'Malley TT, et al
    Diffusible, highly bioactive oligomers represent a critical minority of soluble Abeta in Alzheimer's disease brain.
    Acta Neuropathol. 2018 Apr 23. pii: 10.1007/s00401-018-1846.
    PubMed     Text format     Abstract available


    March 2018
  11. DE ROECK A, Duchateau L, Van Dongen J, Cacace R, et al
    An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer's disease.
    Acta Neuropathol. 2018 Mar 27. pii: 10.1007/s00401-018-1841.
    PubMed     Text format     Abstract available


  12. HECHT M, Kramer LM, von Arnim CAF, Otto M, et al
    Capillary cerebral amyloid angiopathy in Alzheimer's disease: association with allocortical/hippocampal microinfarcts and cognitive decline.
    Acta Neuropathol. 2018 Mar 24. pii: 10.1007/s00401-018-1834.
    PubMed     Text format     Abstract available


    November 2017
  13. TAN CH, Fan CC, Mormino EC, Sugrue LP, et al
    Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition.
    Acta Neuropathol. 2017 Nov 24. pii: 10.1007/s00401-017-1789.
    PubMed     Text format     Abstract available


    June 2017
  14. MCALEESE KE, Walker L, Graham S, Moya ELJ, et al
    Parietal white matter lesions in Alzheimer's disease are associated with cortical neurodegenerative pathology, but not with small vessel disease.
    Acta Neuropathol. 2017 Jun 21. doi: 10.1007/s00401-017-1738.
    PubMed     Text format     Abstract available


  15. LACAMPAGNE A, Liu X, Reiken S, Bussiere R, et al
    Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits.
    Acta Neuropathol. 2017 Jun 19. doi: 10.1007/s00401-017-1733.
    PubMed     Text format     Abstract available


  16. HAURE-MIRANDE JV, Audrain M, Fanutza T, Kim SH, et al
    Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
    Acta Neuropathol. 2017 Jun 13. doi: 10.1007/s00401-017-1737.
    PubMed     Text format     Abstract available


    May 2017
  17. JIN WS, Shen LL, Bu XL, Zhang WW, et al
    Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model.
    Acta Neuropathol. 2017 May 5. doi: 10.1007/s00401-017-1721.
    PubMed     Text format     Abstract available


  18. PASCUAL G, Wadia JS, Zhu X, Keogh E, et al
    Immunological memory to hyperphosphorylated tau in asymptomatic individuals.
    Acta Neuropathol. 2017;133:767-783.
    PubMed     Text format     Abstract available


  19. TAKAHASHI H, Klein ZA, Bhagat SM, Kaufman AC, et al
    Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
    Acta Neuropathol. 2017;133:785-807.
    PubMed     Text format     Abstract available


    April 2017
  20. DE ROECK A, Van den Bossche T, van der Zee J, Verheijen J, et al
    Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer's disease.
    Acta Neuropathol. 2017 Apr 27. doi: 10.1007/s00401-017-1714.
    PubMed     Text format     Abstract available


    March 2017
  21. DURAN-ANIOTZ C, Cornejo VH, Espinoza S, Ardiles AO, et al
    IRE1 signaling exacerbates Alzheimer's disease pathogenesis.
    Acta Neuropathol. 2017 Mar 24. doi: 10.1007/s00401-017-1694.
    PubMed     Text format     Abstract available


  22. SUN M, Bell W, LaClair KD, Ling JP, et al
    Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43.
    Acta Neuropathol. 2017 Mar 22. doi: 10.1007/s00401-017-1701.
    PubMed     Text format     Abstract available


  23. DRUMMOND E, Nayak S, Faustin A, Pires G, et al
    Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease.
    Acta Neuropathol. 2017 Mar 4. doi: 10.1007/s00401-017-1691.
    PubMed     Text format     Abstract available


    February 2017
  24. DEMING Y, Li Z, Kapoor M, Harari O, et al
    Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.
    Acta Neuropathol. 2017 Feb 28. doi: 10.1007/s00401-017-1685.
    PubMed     Text format     Abstract available


    January 2017
  25. ZENG J, Chen L, Wang Z, Chen Q, et al
    Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis.
    Acta Neuropathol. 2017 Jan 27. doi: 10.1007/s00401-017-1669.
    PubMed     Text format     Abstract available


  26. FURMAN JL, Vaquer-Alicea J, White CL 3rd, Cairns NJ, et al
    Widespread tau seeding activity at early Braak stages.
    Acta Neuropathol. 2017;133:91-100.
    PubMed     Text format     Abstract available


  27. JAN A, Jansonius B, Delaidelli A, Somasekharan SP, et al
    eEF2K inhibition blocks Abeta42 neurotoxicity by promoting an NRF2 antioxidant response.
    Acta Neuropathol. 2017;133:101-119.
    PubMed     Text format     Abstract available


    December 2016
  28. DRUMMOND E, Wisniewski T
    Alzheimer's disease: experimental models and reality.
    Acta Neuropathol. 2016 Dec 26. doi: 10.1007/s00401-016-1662.
    PubMed     Text format     Abstract available


  29. CHAPUIS J, Flaig A, Grenier-Boley B, Eysert F, et al
    Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    November 2016
  30. RAMOS-MIGUEL A, Sawada K, Jones AA, Thornton AE, et al
    Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    October 2016
  31. LACLAIR KD, Donde A, Ling JP, Jeong YH, et al
    Depletion of TDP-43 decreases fibril and plaque beta-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  32. KOSS DJ, Jones G, Cranston A, Gardner H, et al
    Soluble pre-fibrillar tau and beta-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  33. SANCHEZ-MEJIAS E, Navarro V, Jimenez S, Sanchez-Mico M, et al
    Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    September 2016
  34. HART NJ, Koronyo Y, Black KL, Koronyo-Hamaoui M, et al
    Ocular indicators of Alzheimer's: exploring disease in the retina.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  35. ANDERSEN OM, Rudolph IM, Willnow TE
    Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    August 2016
  36. KLEIN HU, Bennett DA, De Jager PL
    The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    July 2016
  37. GU BJ, Huang X, Ou A, Rembach A, et al
    Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    May 2016
  38. SHINOHARA M, Murray ME, Frank RD, Shinohara M, et al
    Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    April 2016
  39. KALARIA RN
    Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  40. MONTAGNE A, Nation DA, Pa J, Sweeney MD, et al
    Brain imaging of neurovascular dysfunction in Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  41. KUMAR S, Wirths O, Stuber K, Wunderlich P, et al
    Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.
    Acta Neuropathol. 2016;131:525-37.
    PubMed     Text format     Abstract available


    March 2016
  42. VERHEIJEN J, Van den Bossche T, van der Zee J, Engelborghs S, et al
    A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  43. SADLEIR KR, Kandalepas PC, Buggia-Prevot V, Nicholson DA, et al
    Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Abeta generation in Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  44. MERLINI M, Wanner D, Nitsch RM
    Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


    January 2016
  45. JOSEPHS KA, Murray ME, Whitwell JL, Tosakulwong N, et al
    Updated TDP-43 in Alzheimer's disease staging scheme.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  46. PICCIO L, Deming Y, Del-Aguila JL, Ghezzi L, et al
    Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  47. ZOU C, Shi Y, Ohli J, Schuller U, et al
    Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease.
    Acta Neuropathol. 2016.
    PubMed     Text format     Abstract available


  48. EISELE YS, Duyckaerts C
    Propagation of Ass pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.
    Acta Neuropathol. 2016;131:5-25.
    PubMed     Text format     Abstract available


  49. MCKEE AC, Cairns NJ, Dickson DW, Folkerth RD, et al
    The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.
    Acta Neuropathol. 2016;131:75-86.
    PubMed     Text format     Abstract available


    December 2015
  50. TOLEDO JB, Gopal P, Raible K, Irwin DJ, et al
    Pathological alpha-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  51. LOVE S, Miners JS
    Cerebrovascular disease in ageing and Alzheimer's disease.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  52. ST-AMOUR I, Cicchetti F, Calon F
    Immunotherapies in Alzheimer's disease: Too much, too little, too late or off-target?
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


    November 2015
  53. FOL R, Braudeau J, Ludewig S, Abel T, et al
    Viral gene transfer of APPsalpha rescues synaptic failure in an Alzheimer's disease mouse model.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


    October 2015
  54. WONG H, Levenga J, Cain P, Rothermel B, et al
    RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  55. BOUTER Y, Noguerola JS, Tucholla P, Crespi GA, et al
    Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


  56. XIANG Y, Bu XL, Liu YH, Zhu C, et al
    Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer's disease.
    Acta Neuropathol. 2015;130:487-99.
    PubMed     Text format     Abstract available


    August 2015
  57. ARENDT T, Bruckner MK, Losche A
    Regional mosaic genomic heterogeneity in the elderly and in Alzheimer's disease as a correlate of neuronal vulnerability.
    Acta Neuropathol. 2015.
    PubMed     Text format     Abstract available


    July 2015
  58. DOROSTKAR MM, Zou C, Blazquez-Llorca L, Herms J, et al
    Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities.
    Acta Neuropathol. 2015;130:1-19.
    PubMed     Text format     Abstract available


    January 2015
  59. NHAN HS, Chiang K, Koo EH
    The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes.
    Acta Neuropathol. 2015;129:1-19.
    PubMed     Text format     Abstract available


    October 2014
  60. FRITSCHI SK, Cintron A, Ye L, Mahler J, et al
    Abeta seeds resist inactivation by formaldehyde.
    Acta Neuropathol. 2014;128:477-84.
    PubMed     Text format     Abstract available


  61. BOLUDA S, Toledo JB, Irwin DJ, Raible KM, et al
    A comparison of Abeta amyloid pathology staging systems and correlation with clinical diagnosis.
    Acta Neuropathol. 2014;128:543-50.
    PubMed     Text format     Abstract available


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