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Articles published in Acta Neuropathol

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    April 2021
  1. KANG SS, Ahn EH, Liu X, Bryson M, et al
    ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease.
    Acta Neuropathol. 2021 Apr 25. pii: 10.1007/s00401-021-02315.
    PubMed     Abstract available


  2. VALVERDE A, Dunys J, Lorivel T, Debayle D, et al
    Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.
    Acta Neuropathol. 2021 Apr 21. pii: 10.1007/s00401-021-02308.
    PubMed     Abstract available


  3. SHI Y, Murzin AG, Falcon B, Epstein A, et al
    Correction to: Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
    Acta Neuropathol. 2021 Apr 8. pii: 10.1007/s00401-021-02303.
    PubMed    


  4. TOME SO, Gomes LA, Li X, Vandenberghe R, et al
    TDP-43 interacts with pathological tau protein in Alzheimer's disease.
    Acta Neuropathol. 2021 Apr 2. pii: 10.1007/s00401-021-02295.
    PubMed    


    March 2021
  5. SHI Y, Murzin AG, Falcon B, Epstein A, et al
    Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
    Acta Neuropathol. 2021 Mar 16. pii: 10.1007/s00401-021-02294.
    PubMed     Abstract available


    February 2021
  6. GERRITS E, Brouwer N, Kooistra SM, Woodbury ME, et al
    Distinct amyloid-beta and tau-associated microglia profiles in Alzheimer's disease.
    Acta Neuropathol. 2021 Feb 20. pii: 10.1007/s00401-021-02263.
    PubMed     Abstract available


  7. CACACE R, Van Broeckhoven C
    Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population.
    Acta Neuropathol. 2021 Feb 16. pii: 10.1007/s00401-021-02277.
    PubMed    


  8. KIROLA L, Budde JP, Wang F, Norton J, et al
    Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population.
    Acta Neuropathol. 2021 Feb 16. pii: 10.1007/s00401-021-02271.
    PubMed    


  9. ASHTON NJ, Pascoal TA, Karikari TK, Benedet AL, et al
    Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology.
    Acta Neuropathol. 2021 Feb 14. pii: 10.1007/s00401-021-02275.
    PubMed     Abstract available


    January 2021
  10. HONDIUS DC, Koopmans F, Leistner C, Pita-Illobre D, et al
    The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease.
    Acta Neuropathol. 2021 Jan 25. pii: 10.1007/s00401-020-02261.
    PubMed     Abstract available


  11. MATCHETT BJ, Grinberg LT, Theofilas P, Murray ME, et al
    The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer's disease.
    Acta Neuropathol. 2021 Jan 11. pii: 10.1007/s00401-020-02248.
    PubMed     Abstract available


    December 2020
  12. SEPULVEDA-FALLA D, Chavez-Gutierrez L, Portelius E, Velez JI, et al
    A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease.
    Acta Neuropathol. 2020 Dec 14. pii: 10.1007/s00401-020-02249.
    PubMed     Abstract available


    October 2020
  13. VAILLANT-BEUCHOT L, Mary A, Pardossi-Piquard R, Bourgeois A, et al
    Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains.
    Acta Neuropathol. 2020 Oct 20. pii: 10.1007/s00401-020-02234.
    PubMed     Abstract available


    September 2020
  14. EVANS CE, Miners JS, Piva G, Willis CL, et al
    Correction to: ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease.
    Acta Neuropathol. 2020 Sep 27. pii: 10.1007/s00401-020-02229.
    PubMed     Abstract available


  15. BOON BDC, Bulk M, Jonker AJ, Morrema THJ, et al
    The coarse-grained plaque: a divergent Abeta plaque-type in early-onset Alzheimer's disease.
    Acta Neuropathol. 2020 Sep 14. pii: 10.1007/s00401-020-02198.
    PubMed     Abstract available


    August 2020
  16. KORTE N, Nortley R, Attwell D
    Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease.
    Acta Neuropathol. 2020 Aug 31. pii: 10.1007/s00401-020-02215.
    PubMed     Abstract available


  17. NGUYEN AT, Wang K, Hu G, Wang X, et al
    APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease.
    Acta Neuropathol. 2020 Aug 25. pii: 10.1007/s00401-020-02200.
    PubMed     Abstract available


  18. IKONOMOVIC MD, Buckley CJ, Abrahamson EE, Kofler JK, et al
    Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-beta plaques in Alzheimer's disease.
    Acta Neuropathol. 2020 Aug 9. pii: 10.1007/s00401-020-02175.
    PubMed     Abstract available


  19. DAI DL, Tropea TF, Robinson JL, Suh E, et al
    ADNC-RS, a clinical-genetic risk score, predicts Alzheimer's pathology in autopsy-confirmed Parkinson's disease and Dementia with Lewy bodies.
    Acta Neuropathol. 2020 Aug 4. pii: 10.1007/s00401-020-02199.
    PubMed     Abstract available


  20. LAU HHC, Ingelsson M, Watts JC
    The existence of Abeta strains and their potential for driving phenotypic heterogeneity in Alzheimer's disease.
    Acta Neuropathol. 2020 Aug 2. pii: 10.1007/s00401-020-02201.
    PubMed     Abstract available


    July 2020
  21. KENT SA, Spires-Jones TL, Durrant CS
    The physiological roles of tau and Abeta: implications for Alzheimer's disease pathology and therapeutics.
    Acta Neuropathol. 2020 Jul 29. pii: 10.1007/s00401-020-02196.
    PubMed     Abstract available


  22. LANTERO RODRIGUEZ J, Karikari TK, Suarez-Calvet M, Troakes C, et al
    Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline.
    Acta Neuropathol. 2020 Jul 27. pii: 10.1007/s00401-020-02195.
    PubMed     Abstract available


  23. READHEAD B, Haure-Mirande JV, Mastroeni D, Audrain M, et al
    miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease.
    Acta Neuropathol. 2020 Jul 14. pii: 10.1007/s00401-020-02185.
    PubMed     Abstract available


    June 2020
  24. YOUNAS N, Zafar S, Shafiq M, Noor A, et al
    SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer's disease.
    Acta Neuropathol. 2020 Jun 23. pii: 10.1007/s00401-020-02178.
    PubMed     Abstract available


    April 2020
  25. DEMAREST TG, Varma VR, Estrada D, Babbar M, et al
    Biological sex and DNA repair deficiency drive Alzheimer's disease via systemic metabolic remodeling and brain mitochondrial dysfunction.
    Acta Neuropathol. 2020 Apr 24. pii: 10.1007/s00401-020-02152.
    PubMed     Abstract available


    February 2020
  26. LIU G, Zhang H, Liu B, Wang T, et al
    rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer's disease patients compared with controls.
    Acta Neuropathol. 2020 Feb 29. pii: 10.1007/s00401-020-02135.
    PubMed    


  27. SLEEGERS K
    Expression of ABCA7 in Alzheimer's disease.
    Acta Neuropathol. 2020 Feb 28. pii: 10.1007/s00401-020-02136.
    PubMed    


  28. SHI H, Koronyo Y, Rentsendorj A, Regis GC, et al
    Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina.
    Acta Neuropathol. 2020 Feb 10. pii: 10.1007/s00401-020-02134.
    PubMed     Abstract available


    January 2020
  29. EVANS CE, Miners JS, Piva G, Willis CL, et al
    ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease.
    Acta Neuropathol. 2020 Jan 25. pii: 10.1007/s00401-019-02098.
    PubMed     Abstract available


  30. VAN DER LEE SJ, Conway OJ, Jansen I, Carrasquillo MM, et al
    Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
    Acta Neuropathol. 2020 Jan 18. pii: 10.1007/s00401-019-02107.
    PubMed     Abstract available


  31. SMITH R, Pawlik D, Nilsson CF, Englund E, et al
    [18F]Flortaucipir distinguishes Alzheimer's disease from progressive supranuclear palsy pathology in a mixed-pathology case.
    Acta Neuropathol. 2020 Jan 4. pii: 10.1007/s00401-019-02121.
    PubMed    


    December 2019
  32. THIERRY M, Boluda S, Delatour B, Marty S, et al
    Human subiculo-fornico-mamillary system in Alzheimer's disease: Tau seeding by the pillar of the fornix.
    Acta Neuropathol. 2019 Dec 10. pii: 10.1007/s00401-019-02108.
    PubMed     Abstract available


  33. KOPER MJ, Van Schoor E, Ospitalieri S, Vandenberghe R, et al
    Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer's disease.
    Acta Neuropathol. 2019 Dec 4. pii: 10.1007/s00401-019-02103.
    PubMed     Abstract available


    August 2019
  34. SAHA S, Siddiqui SS, Khan N, Verhagen A, et al
    Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant.
    Acta Neuropathol. 2019 Aug 22. pii: 10.1007/s00401-019-02065.
    PubMed    


  35. GOMES LA, Hipp SA, Rijal Upadhaya A, Balakrishnan K, et al
    Abeta-induced acceleration of Alzheimer-related tau-pathology spreading and its association with prion protein.
    Acta Neuropathol. 2019 Aug 14. pii: 10.1007/s00401-019-02053.
    PubMed     Abstract available


  36. MRDJEN D, Fox EJ, Bukhari SA, Montine KS, et al
    The basis of cellular and regional vulnerability in Alzheimer's disease.
    Acta Neuropathol. 2019 Aug 7. pii: 10.1007/s00401-019-02054.
    PubMed     Abstract available


    July 2019
  37. PROKOP S, Miller KR, Labra SR, Pitkin RM, et al
    Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples.
    Acta Neuropathol. 2019 Jul 26. pii: 10.1007/s00401-019-02048.
    PubMed     Abstract available


  38. SLEEGERS K, Van Broeckhoven C
    Novel Alzheimer's disease risk genes: exhaustive investigation is paramount.
    Acta Neuropathol. 2019 Jul 12. pii: 10.1007/s00401-019-02041.
    PubMed    


    June 2019
  39. PETERSEN C, Nolan AL, de Paula Franca Resende E, Miller Z, et al
    Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation.
    Acta Neuropathol. 2019 Jun 27. pii: 10.1007/s00401-019-02036.
    PubMed     Abstract available


    May 2019
  40. VAN DER LEE SJ, Conway OJ, Jansen I, Carrasquillo MM, et al
    A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
    Acta Neuropathol. 2019 May 27. pii: 10.1007/s00401-019-02026.
    PubMed     Abstract available


    April 2019
  41. BOZA-SERRANO A, Ruiz R, Sanchez-Varo R, Garcia-Revilla J, et al
    Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
    Acta Neuropathol. 2019 Apr 20. pii: 10.1007/s00401-019-02013.
    PubMed     Abstract available


  42. DOURLEN P, Kilinc D, Malmanche N, Chapuis J, et al
    The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?
    Acta Neuropathol. 2019 Apr 13. pii: 10.1007/s00401-019-02004.
    PubMed     Abstract available


  43. ESTUS S, Shaw BC, Devanney N, Katsumata Y, et al
    Evaluation of CD33 as a genetic risk factor for Alzheimer's disease.
    Acta Neuropathol. 2019 Apr 4. pii: 10.1007/s00401-019-02000.
    PubMed     Abstract available


    March 2019
  44. CAMPION D, Charbonnier C, Nicolas G
    SORL1 genetic variants and Alzheimer disease risk: a literature review and meta-analysis of sequencing data.
    Acta Neuropathol. 2019 Mar 25. pii: 10.1007/s00401-019-01991.
    PubMed     Abstract available


  45. DE ROECK A, Van Broeckhoven C, Sleegers K
    The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics.
    Acta Neuropathol. 2019 Mar 22. pii: 10.1007/s00401-019-01994.
    PubMed     Abstract available


    February 2019
  46. BOURASSA P, Tremblay C, Schneider JA, Bennett DA, et al
    Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease.
    Acta Neuropathol. 2019 Feb 7. pii: 10.1007/s00401-019-01967.
    PubMed     Abstract available


  47. SEMICK SA, Bharadwaj RA, Collado-Torres L, Tao R, et al
    Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease.
    Acta Neuropathol. 2019 Feb 2. pii: 10.1007/s00401-019-01966.
    PubMed     Abstract available


  48. JOSEPHS KA, Murray ME, Tosakulwong N, Weigand SD, et al
    Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains.
    Acta Neuropathol. 2019;137:227-238.
    PubMed     Abstract available


  49. NICOLAS G, Veltman JA
    The role of de novo mutations in adult-onset neurodegenerative disorders.
    Acta Neuropathol. 2019;137:183-207.
    PubMed     Abstract available


    January 2019
  50. VERGARA C, Houben S, Suain V, Yilmaz Z, et al
    Amyloid-beta pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo.
    Acta Neuropathol. 2019 Jan 1. pii: 10.1007/s00401-018-1953.
    PubMed     Abstract available


    December 2018
  51. KRAUS A, Saijo E, Metrick MA 2nd, Newell K, et al
    Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease.
    Acta Neuropathol. 2018 Dec 20. pii: 10.1007/s00401-018-1947.
    PubMed     Abstract available


  52. CICOGNOLA C, Brinkmalm G, Wahlgren J, Portelius E, et al
    Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease.
    Acta Neuropathol. 2018 Dec 13. pii: 10.1007/s00401-018-1948.
    PubMed     Abstract available


    November 2018
  53. MOLINUEVO JL, Ayton S, Batrla R, Bednar MM, et al
    Current state of Alzheimer's fluid biomarkers.
    Acta Neuropathol. 2018 Nov 28. pii: 10.1007/s00401-018-1932.
    PubMed     Abstract available


  54. FROSCH MP
    "When sex influences the brain: implications for Alzheimer disease".
    Acta Neuropathol. 2018 Nov 15. pii: 10.1007/s00401-018-1931.
    PubMed    


  55. WALTER S, Jumpertz T, Huttenrauch M, Ogorek I, et al
    The metalloprotease ADAMTS4 generates N-truncated Abeta4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
    Acta Neuropathol. 2018 Nov 13. pii: 10.1007/s00401-018-1929.
    PubMed     Abstract available


  56. BROCE IJ, Tan CH, Fan CC, Jansen I, et al
    Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease.
    Acta Neuropathol. 2018 Nov 9. pii: 10.1007/s00401-018-1928.
    PubMed     Abstract available


    October 2018
  57. MORRIS GP, Clark IA, Vissel B
    Questions concerning the role of amyloid-beta in the definition, aetiology and diagnosis of Alzheimer's disease.
    Acta Neuropathol. 2018 Oct 22. pii: 10.1007/s00401-018-1918.
    PubMed     Abstract available


  58. OVEISGHARAN S, Arvanitakis Z, Yu L, Farfel J, et al
    Sex differences in Alzheimer's disease and common neuropathologies of aging.
    Acta Neuropathol. 2018 Oct 17. pii: 10.1007/s00401-018-1920.
    PubMed     Abstract available


  59. FALCON B, Zhang W, Schweighauser M, Murzin AG, et al
    Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
    Acta Neuropathol. 2018 Oct 1. pii: 10.1007/s00401-018-1914.
    PubMed     Abstract available


    September 2018
  60. KVARTSBERG H, Lashley T, Murray CE, Brinkmalm G, et al
    The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer's disease.
    Acta Neuropathol. 2018 Sep 22. pii: 10.1007/s00401-018-1910.
    PubMed     Abstract available


  61. COURADE JP, Angers R, Mairet-Coello G, Pacico N, et al
    Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau.
    Acta Neuropathol. 2018 Sep 20. pii: 10.1007/s00401-018-1911.
    PubMed     Abstract available


  62. LIESINGER AM, Graff-Radford NR, Duara R, Carter RE, et al
    Sex and age interact to determine clinicopathologic differences in Alzheimer's disease.
    Acta Neuropathol. 2018 Sep 15. pii: 10.1007/s00401-018-1908.
    PubMed     Abstract available


  63. PICKETT EK, Rose J, McCrory C, McKenzie CA, et al
    Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease.
    Acta Neuropathol. 2018 Sep 6. pii: 10.1007/s00401-018-1903.
    PubMed     Abstract available


    August 2018
  64. JELLINGER KA
    Different patterns of hippocampal tau pathology in Alzheimer's disease and PART.
    Acta Neuropathol. 2018 Aug 7. pii: 10.1007/s00401-018-1894.
    PubMed    


    July 2018
  65. HEINSEN H, Grinberg LT
    On the origin of tau seeding activity in Alzheimer's disease.
    Acta Neuropathol. 2018 Jul 23. pii: 10.1007/s00401-018-1890.
    PubMed    


  66. KHAN SS, LaCroix M, Boyle G, Sherman MA, et al
    Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons.
    Acta Neuropathol. 2018 Jul 11. pii: 10.1007/s00401-018-1886.
    PubMed     Abstract available


  67. DEMING Y, Dumitrescu L, Barnes LL, Thambisetty M, et al
    Sex-specific genetic predictors of Alzheimer's disease biomarkers.
    Acta Neuropathol. 2018 Jul 2. pii: 10.1007/s00401-018-1881.
    PubMed     Abstract available


  68. SARDAR SINHA M, Ansell-Schultz A, Civitelli L, Hildesjo C, et al
    Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers.
    Acta Neuropathol. 2018;136:41-56.
    PubMed     Abstract available


    June 2018
  69. ROBINSON JL, Corrada MM, Kovacs GG, Dominique M, et al
    Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study.
    Acta Neuropathol. 2018 Jun 18. pii: 10.1007/s00401-018-1872.
    PubMed     Abstract available


    May 2018
  70. MANN DMA, Davidson YS, Robinson AC, Allen N, et al
    Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease.
    Acta Neuropathol. 2018 May 16. pii: 10.1007/s00401-018-1866.
    PubMed     Abstract available


  71. KAUFMAN SK, Del Tredici K, Thomas TL, Braak H, et al
    Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART.
    Acta Neuropathol. 2018 May 11. pii: 10.1007/s00401-018-1855.
    PubMed     Abstract available


    April 2018
  72. ANDROUIN A, Potier B, Nagerl UV, Cattaert D, et al
    Evidence for altered dendritic spine compartmentalization in Alzheimer's disease and functional effects in a mouse model.
    Acta Neuropathol. 2018 Apr 25. pii: 10.1007/s00401-018-1847.
    PubMed     Abstract available


  73. HONG W, Wang Z, Liu W, O'Malley TT, et al
    Diffusible, highly bioactive oligomers represent a critical minority of soluble Abeta in Alzheimer's disease brain.
    Acta Neuropathol. 2018 Apr 23. pii: 10.1007/s00401-018-1846.
    PubMed     Abstract available


    March 2018
  74. DE ROECK A, Duchateau L, Van Dongen J, Cacace R, et al
    An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer's disease.
    Acta Neuropathol. 2018 Mar 27. pii: 10.1007/s00401-018-1841.
    PubMed     Abstract available


  75. HECHT M, Kramer LM, von Arnim CAF, Otto M, et al
    Capillary cerebral amyloid angiopathy in Alzheimer's disease: association with allocortical/hippocampal microinfarcts and cognitive decline.
    Acta Neuropathol. 2018 Mar 24. pii: 10.1007/s00401-018-1834.
    PubMed     Abstract available


    November 2017
  76. TAN CH, Fan CC, Mormino EC, Sugrue LP, et al
    Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition.
    Acta Neuropathol. 2017 Nov 24. pii: 10.1007/s00401-017-1789.
    PubMed     Abstract available


    June 2017
  77. MCALEESE KE, Walker L, Graham S, Moya ELJ, et al
    Parietal white matter lesions in Alzheimer's disease are associated with cortical neurodegenerative pathology, but not with small vessel disease.
    Acta Neuropathol. 2017 Jun 21. doi: 10.1007/s00401-017-1738.
    PubMed     Abstract available


  78. LACAMPAGNE A, Liu X, Reiken S, Bussiere R, et al
    Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits.
    Acta Neuropathol. 2017 Jun 19. doi: 10.1007/s00401-017-1733.
    PubMed     Abstract available


  79. HAURE-MIRANDE JV, Audrain M, Fanutza T, Kim SH, et al
    Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
    Acta Neuropathol. 2017 Jun 13. doi: 10.1007/s00401-017-1737.
    PubMed     Abstract available


    May 2017
  80. JIN WS, Shen LL, Bu XL, Zhang WW, et al
    Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model.
    Acta Neuropathol. 2017 May 5. doi: 10.1007/s00401-017-1721.
    PubMed     Abstract available


  81. PASCUAL G, Wadia JS, Zhu X, Keogh E, et al
    Immunological memory to hyperphosphorylated tau in asymptomatic individuals.
    Acta Neuropathol. 2017;133:767-783.
    PubMed     Abstract available


  82. TAKAHASHI H, Klein ZA, Bhagat SM, Kaufman AC, et al
    Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
    Acta Neuropathol. 2017;133:785-807.
    PubMed     Abstract available


    April 2017
  83. DE ROECK A, Van den Bossche T, van der Zee J, Verheijen J, et al
    Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer's disease.
    Acta Neuropathol. 2017 Apr 27. doi: 10.1007/s00401-017-1714.
    PubMed     Abstract available


    March 2017
  84. DURAN-ANIOTZ C, Cornejo VH, Espinoza S, Ardiles AO, et al
    IRE1 signaling exacerbates Alzheimer's disease pathogenesis.
    Acta Neuropathol. 2017 Mar 24. doi: 10.1007/s00401-017-1694.
    PubMed     Abstract available


  85. SUN M, Bell W, LaClair KD, Ling JP, et al
    Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43.
    Acta Neuropathol. 2017 Mar 22. doi: 10.1007/s00401-017-1701.
    PubMed     Abstract available


  86. DRUMMOND E, Nayak S, Faustin A, Pires G, et al
    Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease.
    Acta Neuropathol. 2017 Mar 4. doi: 10.1007/s00401-017-1691.
    PubMed     Abstract available


    February 2017
  87. DEMING Y, Li Z, Kapoor M, Harari O, et al
    Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.
    Acta Neuropathol. 2017 Feb 28. doi: 10.1007/s00401-017-1685.
    PubMed     Abstract available


    January 2017
  88. ZENG J, Chen L, Wang Z, Chen Q, et al
    Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis.
    Acta Neuropathol. 2017 Jan 27. doi: 10.1007/s00401-017-1669.
    PubMed     Abstract available


  89. FURMAN JL, Vaquer-Alicea J, White CL 3rd, Cairns NJ, et al
    Widespread tau seeding activity at early Braak stages.
    Acta Neuropathol. 2017;133:91-100.
    PubMed     Abstract available


  90. JAN A, Jansonius B, Delaidelli A, Somasekharan SP, et al
    eEF2K inhibition blocks Abeta42 neurotoxicity by promoting an NRF2 antioxidant response.
    Acta Neuropathol. 2017;133:101-119.
    PubMed     Abstract available


    December 2016
  91. DRUMMOND E, Wisniewski T
    Alzheimer's disease: experimental models and reality.
    Acta Neuropathol. 2016 Dec 26. doi: 10.1007/s00401-016-1662.
    PubMed     Abstract available


  92. CHAPUIS J, Flaig A, Grenier-Boley B, Eysert F, et al
    Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
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