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  Alzheimer's Disease

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22.12.2025

13 Alzheimers Dement
1 Am J Geriatr Psychiatry
1 BMC Neurol
1 Brain
1 Curr Alzheimer Res
4 J Alzheimers Dis
1 J Am Geriatr Soc
2 J Neurol
3 JAMA
1 Nat Neurosci
3 Nature
1 Neurology
5 Neuroscience
1 PLoS One


  Retrieve available abstracts of this week’s articles:
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Single Articles


    Alzheimers Dement

  1. LORENZ LMC, Rohde SK, Luimes MC, Rozemuller AJM, et al
    AD-related plasma biomarkers in centenarians: links to cognition and neuropathology.
    Alzheimers Dement. 2025;21:e70969.
    PubMed         Abstract available

  2. WALTER S, Ptomey L, Head E, Cohen A, et al
    "Being brave, being seen, and having your voice heard": Perspectives of self-advocates and families toward accessible and impactful research of Alzheimer's disease in down syndrome.
    Alzheimers Dement. 2025;21:e70999.
    PubMed         Abstract available

  3. TABLANTE J, Casaletto K, VandeVrede L, Mamuyac E, et al
    The role of bilingualism on functional decline and neurodegeneration in distinct ADRD clinical syndromes.
    Alzheimers Dement. 2025;21:e70991.
    PubMed         Abstract available

  4. JANVE VA, Seto M, Sperling RA, Aisen PS, et al
    Blood gene expression network expression strongly relates to brain amyloid burden.
    Alzheimers Dement. 2025;21:e70982.
    PubMed         Abstract available

  5. KRANZ DL, de Leon Velez O, Ulupinar E, Ozdinler PH, et al
    Identification of a glia-associated amyloid beta oligomer subtype and the rescue from reactive astrogliosis by inhibitor NU-9.
    Alzheimers Dement. 2025;21:e70968.
    PubMed         Abstract available

  6. THOMPSON LI, Gaster B, Hammers DB, Fittipaldi S, et al
    Acceptable standards for clinic-based digital cognitive assessments: Recommendations from the Global CEO Initiative on Alzheimer's Disease.
    Alzheimers Dement. 2025;21:e70966.
    PubMed         Abstract available

  7. CUSTODIO N, Brown G, Custodio B, Montesinos R, et al
    Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia.
    Alzheimers Dement. 2025;21:e70979.
    PubMed         Abstract available

  8. ZHANG B, McEvoy LK, Nguyen S, Espeland MA, et al
    Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease.
    Alzheimers Dement. 2025;21:e70983.
    PubMed         Abstract available

  9. TABRIZI Z, Lim XR, Chakraborty S, Harraz OF, et al
    Systemic Piezo1 activation improves cerebrovascular function in Alzheimer's disease.
    Alzheimers Dement. 2025;21:e71016.
    PubMed         Abstract available

  10. DI DONNA MG, Motta C, Bonomi CG, Bernocchi F, et al
    Reframing TDP-43 in Alzheimer's disease: From co-pathology to neurovascular culprit.
    Alzheimers Dement. 2025;21:e70988.
    PubMed         Abstract available

  11. NJAMNSHI WY, Chiotis K, Tsoy E, Blazhenets G, et al
    Tablet-based Cognitive Assessment Tool (TabCAT) in a multisite study of early-onset Alzheimer's disease.
    Alzheimers Dement. 2025;21:e71012.
    PubMed         Abstract available

  12. KANG KM, Park C, Nam H, Byun MS, et al
    Intracranial stenosis and longitudinal progression of Alzheimer's disease pathologies.
    Alzheimers Dement. 2025;21:e71010.
    PubMed         Abstract available

  13. LIU Y, Zhu H, Wang Y, Luan X, et al
    Apolipoprotein E epsilon4 homozygosity exacerbates retinal and cerebral microvascular dysfunction in Alzheimer's disease: A mediation analysis of vascular contributions to cognitive decline.
    Alzheimers Dement. 2025;21:e71000.
    PubMed         Abstract available


    Am J Geriatr Psychiatry

  14. SAHA S, Spalzang S, Padhy SK, Parmar A, et al
    Reflections on a Study of Low-Dose Agomelatine as Add-on for Agitation in Alzheimer's Disease.
    Am J Geriatr Psychiatry. 2025 Nov 22:S1064-7481(25)00531.
    PubMed        


    BMC Neurol

  15. ZHANG HE, Xiao ML, Ji JJ, Cheng YR, et al
    Integrating machine learning and experiments to elucidate the potential molecular mechanisms of methylparaben-induced Alzheimer's disease: evidence from a Tau hyperphosphorylation cell model.
    BMC Neurol. 2025 Dec 18. doi: 10.1186/s12883-025-04582.
    PubMed         Abstract available


    Brain

  16. ZU J, Li C, Cui M, Liu X, et al
    Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an Alzheimer's disease model.
    Brain. 2025 Dec 15:awaf462. doi: 10.1093.
    PubMed         Abstract available


    Curr Alzheimer Res

  17. HOSSEINI SF, Akbarabadi P, Noorani F, Kazemi D, et al
    Association of Brain and Ventricular Boundary Shift Integral Measurements with CSF Biomarkers: A Case-Control Study.
    Curr Alzheimer Res. 2025;22:359-367.
    PubMed         Abstract available


    J Alzheimers Dis

  18. LENG L, Liao Z, Lu P, Sun Y, et al
    Real-world experience with baseline characteristics and safety of lecanemab for Alzheimer's disease in Eastern China.
    J Alzheimers Dis. 2025 Dec 15:13872877251406619. doi: 10.1177/13872877251406619.
    PubMed         Abstract available

  19. BOCCARDI V
    From risk to prevention: Clinical and public health strategies to reduce Alzheimer's disease burden.
    J Alzheimers Dis. 2025 Dec 16:13872877251407715. doi: 10.1177/13872877251407715.
    PubMed         Abstract available

  20. MUTHURAMALINGAM K, Lee HJ
    Carbon nanomaterials for tau targeting in Alzheimer's disease: Theranostic strategies and clinical prospects.
    J Alzheimers Dis. 2025 Dec 19:13872877251407702. doi: 10.1177/13872877251407702.
    PubMed         Abstract available

  21. YOKOI T
    Need for analysis of linguistic factors for elucidating the pathogenesis of Alzheimer's disease: A position paper.
    J Alzheimers Dis. 2025 Dec 19:13872877251407350. doi: 10.1177/13872877251407350.
    PubMed         Abstract available


    J Am Geriatr Soc

  22. GHAHREMANI M, Smith EE, Ismail Z
    Persistent Functional Impairment as an Early Indicator of Alzheimer Disease Pathology and Progression.
    J Am Geriatr Soc. 2025 Dec 15. doi: 10.1111/jgs.70247.
    PubMed         Abstract available


    J Neurol

  23. DUAN X, Wang F, Liu W, Xie Y, et al
    The diagnostic value of plasma Abeta42 and Abeta40 in Alzheimer's disease: current status, challenges, and impacting variables.
    J Neurol. 2025;273:30.
    PubMed         Abstract available

  24. GUILLEN N, Esteller D, Sarto J, Perales I, et al
    Plasma p-Tau217 and GFAP predict widespread cognitive decline in Alzheimer's disease.
    J Neurol. 2025;273:28.
    PubMed         Abstract available


    JAMA

  25. KNOPMAN DS
    Valacyclovir and Symptomatic Alzheimer Disease-No Evidence for Benefit.
    JAMA. 2025 Dec 17. doi: 10.1001/jama.2025.20795.
    PubMed        


  26. Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: Research Summary.
    JAMA. 2025 Dec 17:e2522830. doi: 10.1001/jama.2025.22830.
    PubMed        

  27. DEVANAND DP, Wisniewski T, Razlighi Q, Qian M, et al
    Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial.
    JAMA. 2025 Dec 17:e2521738. doi: 10.1001/jama.2025.21738.
    PubMed         Abstract available


    Nat Neurosci

  28. GREEN NFO, Sutton GJ, Perez-Burillo J, Wang J, et al
    CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer's disease.
    Nat Neurosci. 2025 Dec 18. doi: 10.1038/s41593-025-02154.
    PubMed         Abstract available


    Nature

  29. CASAMITJANA A, Mancini M, Robinson E, Peter L, et al
    A probabilistic histological atlas of the human brain for MRI segmentation.
    Nature. 2025;648:678-685.
    PubMed         Abstract available

  30. AARSLAND D, Sunde AL, Tovar-Rios DA, Leuzy A, et al
    Prevalence of Alzheimer's disease pathology in the community.
    Nature. 2025 Dec 17. doi: 10.1038/s41586-025-09841.
    PubMed         Abstract available

  31. MULLARD A
    How common is Alzheimer's? Blood-test study holds surprises.
    Nature. 2025 Dec 17. doi: 10.1038/d41586-025-04133.
    PubMed        


    Neurology

  32. DU Y, Borne Y, Samuelsson J, Glans I, et al
    High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence From a 25-Year Prospective Cohort Study.
    Neurology. 2026;106:e214343.
    PubMed         Abstract available


    Neuroscience

  33. IOANNIDOU E, Vavilis T, Bourtzos Z, Stamoula E, et al
    Corrigendum to "A review of the TGF-beta1 pathway in Alzheimer's disease and depression: Possible restoration potential of antidepressants" [Neuroscience 585 (2025) 429-440].
    Neuroscience. 2025;593:170.
    PubMed        

  34. MEHMOOD A, Shahid F, Khan R, AlZu'bi H, et al
    A review of deep learning techniques in Alzheimer's disease with emphasis on data tools and transfer learning.
    Neuroscience. 2025;593:242-254.
    PubMed         Abstract available

  35. JOGESHWAR BK, Lu S, Nephew BC
    Neuroanatomical-based machine learning prediction of Alzheimer's Disease across sex and age.
    Neuroscience. 2025 Dec 14:S0306-4522(25)01177.
    PubMed         Abstract available

  36. ZHOU W, Qu R, Luo W, Zhang H, et al
    Identification of cognitive brain diseases using a dual-branch siamese network on structural magnetic resonance imaging data.
    Neuroscience. 2025;591:83-92.
    PubMed         Abstract available

  37. HU K, Li C, Liu Y, Pan C, et al
    Arabinoxylan ameliorates memory deficits and amyloid pathology in male 5 x FAD mice via modulation of gut microbiota structure.
    Neuroscience. 2025;591:52-62.
    PubMed         Abstract available


    PLoS One

  38. TANJIN R, Al-Amin M, Etee JM, Siddika A, et al
    An evaluation of Roluperidone as a promising repurposing candidate for Alzheimer's Disease: A Computational Investigation.
    PLoS One. 2025;20:e0338211.
    PubMed         Abstract available


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