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  Alzheimer's Disease

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10.11.2025

1 Alzheimer Dis Assoc Disord
12 Alzheimers Dement
1 Am J Geriatr Psychiatry
2 Brain
1 Exp Neurol
17 J Alzheimers Dis
1 J Neurochem
1 J Neurol
2 Nat Med
2 Nat Neurosci
1 Nat Rev Neurol
1 Nature
1 Neurobiol Aging
4 Neurobiol Dis
3 Neurology
1 Neuropsychology
1 Neurosci Lett
1 Neuroscience
1 PLoS One


  Retrieve available abstracts of this week’s articles:
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Single Articles


    Alzheimer Dis Assoc Disord

  1. LEHRER S, Rheinstein PH
    rs140926439 Variant in the Fibronectin FN1 Gene Lowers Risk of Alzheimer Disease in APOEepsilon4 Carriers in the UK Biobank Cohort.
    Alzheimer Dis Assoc Disord. 2025 Oct 30. doi: 10.1097/WAD.0000000000000692.
    PubMed         Abstract available


    Alzheimers Dement

  2. CHONG CHIE JAK, Persohn SA, Pandey RS, Carter GW, et al
    Neurometabolic and vascular dysfunction as an early diagnostic for Alzheimer's disease and related dementias.
    Alzheimers Dement. 2025;21:e70790.
    PubMed         Abstract available


  3. Correction to "Age and sex are associated with Alzheimer's disease neuropathology in Down syndrome".
    Alzheimers Dement. 2025;21:e70914.
    PubMed        

  4. UDEH-MOMOH CT, Aliwa B, Atwoli L, Blackmon K, et al
    Identifying sex- and gender-specific endocrinological, lifestyle, psychosocial, and socio-cultural targets for Alzheimer's disease prevention in Africans: The Female Brain Health and Endocrine Research in Africa (FemBER-Africa) project.
    Alzheimers Dement. 2025;21:e70887.
    PubMed         Abstract available

  5. ROSADO AM, Vizcarra JC, Sharma SRR, Keene CD, et al
    Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions.
    Alzheimers Dement. 2025;21:e70775.
    PubMed         Abstract available


  6. Correction to "Comparison of plasma p-tau217/Abeta42, p-tau217, and Abeta42/Abeta40 biomarkers by race to detect Alzheimer's disease".
    Alzheimers Dement. 2025;21:e70913.
    PubMed        

  7. PIRRAGLIA E, Osorio RS, Glodzik L, Ashebir Y, et al
    Subtypes of multiple-etiology dementias and the heterogeneous impact of APOE variants.
    Alzheimers Dement. 2025;21:e70872.
    PubMed         Abstract available

  8. LOI KJ, Radtke N, Kiriluk C, Noureldein MH, et al
    Shared genes and pathways in dementia: Insights from genome-wide association studies.
    Alzheimers Dement. 2025;21:e70845.
    PubMed         Abstract available

  9. RUSS KA, Lacy K, Dage JL, Foroud T, et al
    The National Centralized Repository for Alzheimer's Disease and Related Dementia's Biomarker Assay Laboratory: A Resource for the Alzheimer's Disease Research Community.
    Alzheimers Dement. 2025;21:e70774.
    PubMed         Abstract available

  10. NAMDUL T, MacLehose R, Pasang T, Madesclaire O, et al
    Community-based participatory research on Alzheimer's disease and related dementias among Tibetan Buddhist monks in South India: The Lifestyle Assessment and Monastic Aging Study (LAMAS).
    Alzheimers Dement. 2025;21:e70834.
    PubMed         Abstract available

  11. PAHLKE S, Kahale LA, Mahinrad S, Sousa-Pinto B, et al
    Blood-based biomarkers for detecting Alzheimer's disease pathology in cognitively impaired individuals within specialized care settings: A systematic review and meta-analysis.
    Alzheimers Dement. 2025;21:e70828.
    PubMed         Abstract available

  12. BANGS MC, Gadhavi J, Carter EK, Ping L, et al
    Proteomic subtyping of Alzheimer's disease CSF links blood-brain barrier dysfunction to reduced levels of tau and synaptic biomarkers.
    Alzheimers Dement. 2025;21:e70830.
    PubMed         Abstract available

  13. AU R, Bose N, Imam F, Kolachalama VB, et al
    Technological advances enabling an enhanced understanding of early Alzheimer's disease.
    Alzheimers Dement. 2025;21:e70883.
    PubMed         Abstract available


    Am J Geriatr Psychiatry

  14. PEREIRA DA SILVA AM, de Deus O, Ribeiro FV, Tudella GCN, et al
    Efficacy and Safety of Lithium for Behavioral and Cognitive Symptoms in Alzheimer's Disease Dementia: A Systematic Review With Frequentist and Bayesian Meta-Analysis.
    Am J Geriatr Psychiatry. 2025 Oct 4:S1064-7481(25)00496.
    PubMed         Abstract available


    Brain

  15. RAKET LL, Pichet Binette A, Mattsson-Carlgren N, Janelidze S, et al
    Estimating the time course of biomarker changes in Alzheimer's disease.
    Brain. 2025 Nov 3:awaf413. doi: 10.1093.
    PubMed         Abstract available

  16. WESSELING A, Calandri IL, Bouwman MMA, Reijner N, et al
    Amygdalar and hippocampal volume loss in limbic-predominant age-related TDP-43 encephalopathy.
    Brain. 2025;148:3913-3923.
    PubMed         Abstract available


    Exp Neurol

  17. YAO M, Li Z, Lin Y, Cai H, et al
    Hyperbaric oxygen therapy ameliorates Alzheimer's disease pathology by restoration of mitophagy and suppressing neuroinflammation in 5xFAD mice.
    Exp Neurol. 2025 Nov 4:115534. doi: 10.1016/j.expneurol.2025.115534.
    PubMed         Abstract available


    J Alzheimers Dis

  18. WEBSTER H, Zelinsky M, Rico V, Martinez K, et al
    Reconciling recommendations for ethical sharing of biomarker results with Alzheimer's disease research participants: A systematic review and qualitative synthesis.
    J Alzheimers Dis. 2025 Nov 5:13872877251392555. doi: 10.1177/13872877251392555.
    PubMed         Abstract available

  19. FERNANDEZ FX, Grandner MA
    Amyloid-beta as a cytokine-like somnogen: Rethinking its role in sleep homeostasis and Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 5:13872877251392186. doi: 10.1177/13872877251392186.
    PubMed         Abstract available

  20. ALSHAHERI DURAZO A, McDonough IM
    Midlife brain vulnerability: Sex differences in functional magnetic resonance imaging and Alzheimer's disease risk.
    J Alzheimers Dis. 2025 Nov 5:13872877251392238. doi: 10.1177/13872877251392238.
    PubMed         Abstract available

  21. SHINOZAKI M, Hishida H, Gondo Y, Yamamoto M, et al
    Machine learning model for predicting the conversion to dementia using the Cube Copying Test.
    J Alzheimers Dis. 2025;108.
    PubMed         Abstract available

  22. HUANG Y, Li Z, Liu F, Li B, et al
    Application of machine learning in EEG-based dementia diagnosis: Classification and differential diagnosis.
    J Alzheimers Dis. 2025;108.
    PubMed         Abstract available

  23. DUBBELMAN MA, Elias U, Palmer P, Dafni-Merom A, et al
    Investigating the associations between tau and mental orientation among cognitively unimpaired individuals.
    J Alzheimers Dis. 2025;108.
    PubMed         Abstract available

  24. LIBON DJ, Swenson R, Langford DT, Cosentino S, et al
    Precision neurocognition: An emerging diagnostic paradigm leveraging digital cognitive assessment technology.
    J Alzheimers Dis. 2025;108.
    PubMed         Abstract available

  25. SINGH D, Grazia A, Reiz A, Hermann A, et al
    A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans.
    J Alzheimers Dis. 2025;108.
    PubMed         Abstract available

  26. SILVA-SPINOLA A, Baldeiras I, Santana I, Arrais JP, et al
    Predicting progression of mild cognitive impairment patients through four distinctive subgroups obtained by unsupervised learning algorithms.
    J Alzheimers Dis. 2025;108.
    PubMed         Abstract available

  27. LAUBER MV, Bellitti M, Kapadia K, Jasodanand VH, et al
    Global amyloid burden enhances network efficiency of tau propagation in the brain.
    J Alzheimers Dis. 2025;108.
    PubMed         Abstract available

  28. CHEN Z, Qi B, Jing B, Dong R, et al
    A multi-modal and multi-stage region of interest-based fusion network convolutional neural network model to differentiate progressive mild cognitive impairment from stable mild cognitive impairment.
    J Alzheimers Dis. 2025;108.
    PubMed         Abstract available

  29. CAO Y, Liu S, He Z, Pan W, et al
    Unfriendly dialogue of gut microbiota and lipid metabolism in Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 5:13872877251391771. doi: 10.1177/13872877251391771.
    PubMed         Abstract available

  30. ZENG Z, Dai M, Jing Y, Zhao K, et al
    Exploring toxicity and mechanisms of DDTs in Alzheimer's disease through network toxicology and molecular docking insights.
    J Alzheimers Dis. 2025 Nov 5:13872877251393503. doi: 10.1177/13872877251393503.
    PubMed         Abstract available

  31. SHAW BC, Kaiser KE, Smith BC, Timken JP, et al
    Astrocytes upregulate interleukin-15 in response to neuroinflammation during Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 5:13872877251393275. doi: 10.1177/13872877251393275.
    PubMed         Abstract available

  32. WANG X, Yang X, Duan M, Duan H, et al
    Mitochondrial energy metabolism and Alzheimer's disease: Identifying key differentially expressed genes in blood.
    J Alzheimers Dis. 2025 Nov 6:13872877251387584. doi: 10.1177/13872877251387584.
    PubMed         Abstract available

  33. GARCIA-CHIALVA DE, Itzcovich T, Cifarelli D, Apecetche M, et al
    Clinical and functional evidence supporting the pathogenicity of the novel PSEN1 p.R358P variant in early-onset Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 6:13872877251392236. doi: 10.1177/13872877251392236.
    PubMed         Abstract available

  34. FRANCIA M, Ramesh N, Boltz T, Bot M, et al
    Integrative analysis of cerebrospinal fluid biomarkers, metabolomics, and polygenic risk reveals novel metabolite associations with Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 7:13872877251389924. doi: 10.1177/13872877251389924.
    PubMed         Abstract available


    J Neurochem

  35. BESCHORNER N, Xu Y, Jucker M, Ruiz-Riquelme A, et al
    Amyloid-beta Seeds in Alzheimer's Disease: Research Challenges and Implications.
    J Neurochem. 2025;169:e70267.
    PubMed         Abstract available


    J Neurol

  36. NOLI B, Muqaku B, Gouda M, Manai AL, et al
    VGF AQEE- and GGEE-peptides differentiate between dementia types.
    J Neurol. 2025;272:745.
    PubMed         Abstract available


    Nat Med

  37. JANELIDZE S
    A new blood biomarker for Alzheimer's disease.
    Nat Med. 2025 Nov 3. doi: 10.1038/s41591-025-04028.
    PubMed        

  38. YAU WW, Kirn DR, Rabin JS, Properzi MJ, et al
    Physical activity as a modifiable risk factor in preclinical Alzheimer's disease.
    Nat Med. 2025 Nov 3. doi: 10.1038/s41591-025-03955.
    PubMed         Abstract available


    Nat Neurosci

  39. FERRARI-SOUZA JP, Povala G, Rahmouni N, Bellaver B, et al
    Microglia modulate Abeta-dependent astrocyte reactivity in Alzheimer's disease.
    Nat Neurosci. 2025 Nov 6. doi: 10.1038/s41593-025-02103.
    PubMed         Abstract available

  40. SHEEHAN PW, Fass SB, Sapkota D, Kang S, et al
    A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging.
    Nat Neurosci. 2025;28:2366-2379.
    PubMed         Abstract available


    Nat Rev Neurol

  41. LLIBRE-GUERRA JJ, McDade EM, Schindler SE, Clifford DB, et al
    Towards pharmacological prevention of Alzheimer disease.
    Nat Rev Neurol. 2025 Nov 3. doi: 10.1038/s41582-025-01154.
    PubMed         Abstract available


    Nature

  42. LENHARO M
    Alzheimer's decline slows with just a few thousand steps a day.
    Nature. 2025 Nov 3. doi: 10.1038/d41586-025-03596.
    PubMed        


    Neurobiol Aging

  43. LINGAD JN, Vanderlip CR, Wright S, Sordo L, et al
    Hippocampal 1H-MR spectroscopy metabolites are linked to CSF tau pathology in cognitively unimpaired older adults along the Alzheimer's continuum.
    Neurobiol Aging. 2025;157:89-97.
    PubMed         Abstract available


    Neurobiol Dis

  44. MA C, Campbell K, Kovalenko A, Li J, et al
    Nutrient sensing receptor GPRC6A regulates mTORC1 signaling and Tau biology.
    Neurobiol Dis. 2025;216:107054.
    PubMed         Abstract available

  45. XU G, Angelle C, Huilgol D, Sacilotto P, et al
    Comparison of the ApoE allelic variants in the formation of intracerebral Abeta deposits.
    Neurobiol Dis. 2025;216:107105.
    PubMed         Abstract available

  46. SCHMEETZ J, van de Sande N, Ramakers IHGB, Verhey FRJ, et al
    Enrichment of phosphorylated Tau 181 levels in tear fluid-derived extracellular vesicles.
    Neurobiol Dis. 2025;216:107134.
    PubMed         Abstract available

  47. ANDRAINI T, Faure LM, Mouledous L, Gauzin S, et al
    Targeting adult-born neurons to correct early deficits in pattern separation in the Tg2576 mouse model of Alzheimer's disease.
    Neurobiol Dis. 2025;217:107158.
    PubMed         Abstract available


    Neurology

  48. RAMOS-CEJUDO J, Beiser AS, Lu S, Tanner JA, et al
    Association of Platelet Aggregation With Markers of Alzheimer Disease Pathology in Middle-Aged Participants of the Framingham Heart Study.
    Neurology. 2025;105:e214314.
    PubMed         Abstract available

  49. PRODAN CI, Dale GL
    Platelets and Alzheimer Disease: A Link Worth Exploring.
    Neurology. 2025;105:e214438.
    PubMed        

  50. ROSENAU C, Neuffer J, Kohler S, Helmer C, et al
    Updated LIfestyle for BRAin health (LIBRA2) Score, Genetics, and Risk of Alzheimer Disease, Vascular Dementia, and Stroke in Older Adults.
    Neurology. 2025;105:e214312.
    PubMed         Abstract available


    Neuropsychology

  51. SAARI TT, Aaltonen A, Lohi K, Palviainen T, et al
    Validity of telephone-administered word list learning measures for assessment of episodic memory in aging and Alzheimer's disease.
    Neuropsychology. 2025 Nov 6. doi: 10.1037/neu0001019.
    PubMed         Abstract available


    Neurosci Lett

  52. ZHOU C, Wang Y, Zuo L, Miao Y, et al
    Vitamin D(3) alleviates AD-like pathology in APP/PS1 mice by inhibiting pyroptosis and neuroinflammation via DJ-1/PARK7.
    Neurosci Lett. 2025;867:138385.
    PubMed         Abstract available


    Neuroscience

  53. VANYA, Kumari S, Bagri K, Deshmukh R, et al
    Tangles and Plaques: A deep dive into the pathological hallmarks of Alzheimer's disease.
    Neuroscience. 2025 Oct 30:S0306-4522(25)01048.
    PubMed         Abstract available


    PLoS One

  54. HOSSAIN MR, Al Saber M, Hoque MA, Rahman MS, et al
    Green synthesis of silver nanoparticles from Brownlowia tersa leaf extract: multifaceted evaluation of antibacterial, antioxidant, cytotoxic, and anti-alzheimer potential.
    PLoS One. 2025;20:e0335524.
    PubMed         Abstract available


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