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  Alzheimer's Disease

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17.11.2025

1 Acta Neuropathol
3 Alzheimer Dis Assoc Disord
17 Alzheimers Dement
1 BMC Geriatr
2 Brain
11 J Alzheimers Dis
1 J Neurochem
1 J Neurol
1 J Neurol Neurosurg Psychiatry
2 J Neurosci
2 Nat Neurosci
1 Nature
1 Neurobiol Aging
2 Neurobiol Dis
1 Neuroscience
2 PLoS One


  Retrieve available abstracts of this week’s articles:
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Single Articles


    Acta Neuropathol

  1. PHUONG HT, Tomas RF, Akmese C, Mijares A, et al
    PolyGR-containing aggregates link with pathology and clinical features of Alzheimer's disease.
    Acta Neuropathol. 2025;150:49.
    PubMed         Abstract available


    Alzheimer Dis Assoc Disord

  2. NOGUEIRA MML, Oliveira F, Belfort T, Monteiro A, et al
    The Impact of Awareness of Disease on Quality of Life of People With Alzheimer's Disease.
    Alzheimer Dis Assoc Disord. 2025 Nov 12. doi: 10.1097/WAD.0000000000000682.
    PubMed         Abstract available

  3. URSI GZ, da Silva MR, Nakakogue LM, Fernandes KBP, et al
    Alzheimer Disease Patients Who Survived COVID-19 Have Rapid Disease Progression and a Higher Risk of Death at 5-year Follow-up: A Retrospective Cohort Study.
    Alzheimer Dis Assoc Disord. 2025 Nov 12. doi: 10.1097/WAD.0000000000000700.
    PubMed         Abstract available

  4. MUELLER KD, Soldan A, Langhough R, Bruno D, et al
    Proper Name Recall as an Early Indicator of Preclinical Alzheimer Disease Pathology.
    Alzheimer Dis Assoc Disord. 2025 Nov 10. doi: 10.1097/WAD.0000000000000695.
    PubMed         Abstract available


    Alzheimers Dement

  5. PRUFER Q C ARAUJO I, Ellingson T, Schwartz NU, Dietz CD, et al
    Blood-based Alzheimer's disease biomarkers in a behavioral neurology clinic: Real-world implementation, clinical utility, and diagnostic performance.
    Alzheimers Dement. 2025;21:e70891.
    PubMed         Abstract available

  6. VENKATESH R, Cardone KM, Bradford Y, Moore AK, et al
    Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction.
    Alzheimers Dement. 2025;21:e70886.
    PubMed         Abstract available

  7. ROUSSET RZ, Dolan CV, Wilson DH, In 't Veld L, et al
    Genetic and environmental contributions to variation in plasma phosphorylated tau 217.
    Alzheimers Dement. 2025;21:e70906.
    PubMed         Abstract available

  8. GEORGE GC, Keller SA, Abner E, Adar S, et al
    The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias.
    Alzheimers Dement. 2025;21:e70810.
    PubMed         Abstract available

  9. CHEN Y, Stevenson TK, Cao Y, Fish LA, et al
    Genetic variation in the Nr1d1 transcription factor binding site shapes metabolism-related protein networks associated with cognitive resilience in an Alzheimer's disease mouse reference panel.
    Alzheimers Dement. 2025;21:e70896.
    PubMed         Abstract available

  10. JEON SY, Byun MS, Choi HJ, Kim YH, et al
    Eligibility for lecanemab and donanemab in Korea under Appropriate Use Recommendations.
    Alzheimers Dement. 2025;21:e70875.
    PubMed         Abstract available

  11. SOHRABPOUR A, Sarovic D, Zetterberg H, Hamalainen MS, et al
    Tracking electrophysiological signatures of Alzheimer's disease: a systematic review of multimodal studies.
    Alzheimers Dement. 2025;21:e70835.
    PubMed         Abstract available

  12. EDWARDS L, Gonzalez AI, Thomas KR, Smirnov DS, et al
    Interactive effects of blood-brain barrier breakdown and Alzheimer's disease biomarker status on cognitive decline in older adults without dementia.
    Alzheimers Dement. 2025;21:e70910.
    PubMed         Abstract available

  13. KING MW, Jacob SM, Sharma A, Lawrence JH, et al
    Circadian rhythms and the light-dark cycle interact to regulate amyloid-beta plaque accumulation and tau phosphorylation in 5xFAD mice.
    Alzheimers Dement. 2025;21:e70885.
    PubMed         Abstract available

  14. OVEISGHARAN S, Yu L, Wang Y, Yang J, et al
    Amyloid beta binding partners in the brain tissue of older adults.
    Alzheimers Dement. 2025;21:e70882.
    PubMed         Abstract available

  15. KIM BH, Seo SW, Kim J, Nho K, et al
    Cerebrospinal fluid proteins in relation to longitudinal cognitive trajectories.
    Alzheimers Dement. 2025;21:e70894.
    PubMed         Abstract available

  16. OOMENS JE, Biber SA, Albert M, Alosco ML, et al
    The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment.
    Alzheimers Dement. 2025;21:e70880.
    PubMed         Abstract available

  17. PAVLIK VN, Weber CJ, Masdeu JC, Baker LD, et al
    Cognitive reserve predicts baseline tau burden in the U.S. POINTER trial imaging cohort.
    Alzheimers Dement. 2025;21:e70892.
    PubMed         Abstract available

  18. DONG X, Bai M, Qian J, Xiao J, et al
    Harmful impact of blood lead on the prevalence of Alzheimer's disease among middle-aged and older adults and the modifying role of physical activity: Evidence from the National Health and Nutrition Examination Survey (NHANES) study.
    Alzheimers Dement. 2025;21:e70785.
    PubMed         Abstract available

  19. LUNA-VIRAMONTES NI, Morlett-Paredes A, Ordonez-Lozano I, de la Cruz-Lopez F, et al
    Brain banks in Latin America: Infrastructure for diagnosis, research, and scientific equity in Mexico and the Caribbean.
    Alzheimers Dement. 2025;21:e70819.
    PubMed         Abstract available

  20. MAGANA-RAMIREZ CM, Gillen DL, Hom CL, Jaimes L Jr, et al
    Neuropsychiatric symptoms and emerging dementia in people with Down syndrome and older adults.
    Alzheimers Dement. 2025;21:e70871.
    PubMed         Abstract available

  21. CHAN KCG, Dodge HH, Sano M, Au R, et al
    Comparable performance of the NACC Uniform Data Set version 3 neuropsychological test battery in assessing longitudinal cognitive change for African American and White participants.
    Alzheimers Dement. 2025;21:e70889.
    PubMed         Abstract available


    BMC Geriatr

  22. LI P, He Y, He M
    The comprehensive impact of exercise interventions on cognitive function and quality of life in alzheimer's disease patients: a systematic review and meta-analysis.
    BMC Geriatr. 2025;25:871.
    PubMed         Abstract available


    Brain

  23. LI LL, Wang RZ, Wang Z, Hu H, et al
    Safety and short-term outcomes of lecanemab for Alzheimer's disease in China: a multicentre study.
    Brain. 2025 Nov 11:awaf427. doi: 10.1093.
    PubMed         Abstract available

  24. LUAN Y, Huang Q, Wang J, Guan Y, et al
    Synaptic density and tau pathology in Alzheimer's disease: a dual role in susceptibility and degeneration.
    Brain. 2025 Nov 13:awaf425. doi: 10.1093.
    PubMed         Abstract available


    J Alzheimers Dis

  25. BOSIRE EN, Kamau LW, Kiio C, Blackmon K, et al
    Community perceptions and willingness to donate biospecimen for Alzheimer's disease research in Nairobi, Kenya.
    J Alzheimers Dis. 2025 Nov 12:13872877251389227. doi: 10.1177/13872877251389227.
    PubMed         Abstract available

  26. BOUTIN S, Houze B, Pichet Binette A, Brambati SM, et al
    Uncovering pathology, subjective cognitive complaints, and sex in early Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 11:13872877251393268. doi: 10.1177/13872877251393268.
    PubMed         Abstract available

  27. VRANCEANU AM, Szapary CL, Cornelius T, Monin JK, et al
    Behavioral dyadic interventions in the context of Alzheimer's disease and related dementia: A call to action.
    J Alzheimers Dis. 2025 Nov 10:13872877251392184. doi: 10.1177/13872877251392184.
    PubMed         Abstract available

  28. DUBOIS KN, Pal S, Reader JM, Jackman B, et al
    Evaluation of a panel of plasma biomarkers for Alzheimer's disease in a diverse research cohort.
    J Alzheimers Dis. 2025 Nov 10:13872877251393405. doi: 10.1177/13872877251393405.
    PubMed         Abstract available

  29. HAMDI A, Stathopoulou P, Gharbi A, Saadouli I, et al
    Salivary microbiome dysbiosis in patients with Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 10:13872877251393229. doi: 10.1177/13872877251393229.
    PubMed         Abstract available

  30. SONG W, Fang M, Geng Z, Pang X, et al
    Mechanistic study of Alzheimer's disease with behavioral and psychological symptoms based on electroencephalography microstates.
    J Alzheimers Dis. 2025 Nov 10:13872877251393715. doi: 10.1177/13872877251393715.
    PubMed         Abstract available

  31. IWAME S, Izu K, Murata Y, Taniguchi M, et al
    Impairment in re-learning of olfactory behaviors in mice expressing intracellular amyloid-beta protein oligomers.
    J Alzheimers Dis. 2025;108:805-823.
    PubMed         Abstract available

  32. MAO R, Zhao S, Chen J, Wang L, et al
    Identification of novel biomarkers for cognitive function via an integrative analysis.
    J Alzheimers Dis. 2025;108:931-947.
    PubMed         Abstract available

  33. BROWN K, Shutes-David A, Wilson K, Shao Y, et al
    Machine learning-based risk scores are associated with conversion to dementia in Veterans.
    J Alzheimers Dis. 2025;108:873-882.
    PubMed         Abstract available

  34. SIMON ZD, McFarland KN, Golde TE, Chakrabarty P, et al
    Sex-dependent effect of amyloidosis on functional network 'hub' topology is associated with downregulated neuronal gene signatures in the APPswe/PSEN1dE9 double transgenic mouse.
    J Alzheimers Dis. 2025;108:893-913.
    PubMed         Abstract available

  35. SAHIN MZ, Yildirim A
    Gonadal hormones and aquaporin-4: Preclinical insights into glymphatic regulation and amyloid clearance.
    J Alzheimers Dis. 2025;108:461-469.
    PubMed         Abstract available


    J Neurochem

  36. CONSTANTINO NJ, Ashley CC, Macauley SL
    The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks.
    J Neurochem. 2025;169:e70294.
    PubMed         Abstract available


    J Neurol

  37. BUONOCORE J, Fratto E, Arcuri F, Vescio B, et al
    Plasma NfL and GFAP in the preclinical stages of neurodegenerative diseases: insights from the UK Biobank.
    J Neurol. 2025;272:755.
    PubMed         Abstract available


    J Neurol Neurosurg Psychiatry

  38. KONG N, Jung JH
    Elevated serum beta-synuclein predicts cognitive decline and progression to dementia.
    J Neurol Neurosurg Psychiatry. 2025;96:1154-1161.
    PubMed         Abstract available


    J Neurosci

  39. YASSINE HN, Hugo C, O'Donovan B, Stephens IO, et al
    APOE-Targeted Therapeutics for Alzheimer's Disease.
    J Neurosci. 2025;45:e1388252025.
    PubMed         Abstract available

  40. BHATTACHARYYA A, de la Torre-Ubieta L, Zhu Y, Head E, et al
    Development of Molecular Neuropathology in Down Syndrome across the Lifespan.
    J Neurosci. 2025;45:e1365252025.
    PubMed         Abstract available


    Nat Neurosci

  41. LAM JYL, Wang K, Bu G
    Flipping APOE to reverse Alzheimer's disease traits.
    Nat Neurosci. 2025 Nov 11. doi: 10.1038/s41593-025-02108.
    PubMed        

  42. GOLDEN LR, Siano DS, Stephens IO, MacLean SM, et al
    APOE4 to APOE2 allelic switching in mice improves Alzheimer's disease-related metabolic signatures, neuropathology and cognition.
    Nat Neurosci. 2025 Nov 11. doi: 10.1038/s41593-025-02094.
    PubMed         Abstract available


    Nature

  43. VON MAYDELL D, Wright SE, Pao PC, Staab C, et al
    ABCA7 variants impact phosphatidylcholine and mitochondria in neurons.
    Nature. 2025;647:462-471.
    PubMed         Abstract available


    Neurobiol Aging

  44. YUAN C, Li L, Lin HY, Aubry AV, et al
    Targeting neuronal activity and neuroinflammation for the treatment of Alzheimer's disease in a mouse model.
    Neurobiol Aging. 2025;157:111-118.
    PubMed         Abstract available


    Neurobiol Dis

  45. ATTALI RS, Farfara D, Cooper I, Levin A, et al
    Corrigendum to "Naphthoquinone-tyrptophan reduces neurotoxic Abeta*56 levels and improves cognition in Alzheimer's disease animal model" Neurobiol Dis. 46(3) (2012):663-72.
    Neurobiol Dis. 2025 Nov 7:107170. doi: 10.1016/j.nbd.2025.107170.
    PubMed        

  46. YANG S, Xie B, Liao D, Sun Y, et al
    Trajectory of olfactory cortex degeneration from normal cognition to Alzheimer's disease: Insights from multimodal neuroimaging.
    Neurobiol Dis. 2025;217:107181.
    PubMed         Abstract available


    Neuroscience

  47. ALI S, Kosar S, Sina RM, Sima A, et al
    Serum bile acids and brain hypometabolism in patients across Alzheimer's disease continuum: An [(18)F]FDG-PET study.
    Neuroscience. 2025 Nov 6:S0306-4522(25)01063.
    PubMed         Abstract available


    PLoS One

  48. CAMPANELLI L, Sendoya JM, Brody S, Galeano P, et al
    Correction: New insights into the molecular biology of Alzheimer's-like cerebral amyloidosis achieved through multi-omics approaches.
    PLoS One. 2025;20:e0336509.
    PubMed         Abstract available

  49. YOO SS, Reddy A, Carroll W, Ploypradith K, et al
    Repeated application of transcranial ultrasound maintains spatial and recognition memory in 5xFAD mice with reduction of amyloid-beta burden.
    PLoS One. 2025;20:e0336114.
    PubMed         Abstract available


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