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  Alzheimer's Disease

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24.11.2025

13 Alzheimers Dement
1 Brain
3 Brain Res
1 Dement Geriatr Cogn Disord
1 Exp Gerontol
2 Exp Neurol
1 Int J Neurosci
6 J Alzheimers Dis
1 J Biol Chem
3 Lancet Neurol
1 Nat Med
1 Nat Neurosci
3 Neurobiol Aging
2 Neurobiol Dis
1 Neurol Genet
1 Neurology
1 PLoS One
1 Proc Natl Acad Sci U S A
2 Rev Neurol (Paris)


  Retrieve available abstracts of this week’s articles:
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Single Articles


    Alzheimers Dement

  1. SUEMOTO CK, Paradela R, Leite REP, Paes VR, et al
    Apolipoprotein E and Alzheimer's disease pathology in a diverse autopsy study.
    Alzheimers Dement. 2025;21:e70927.
    PubMed         Abstract available

  2. ANDREWS SJ, Tolosa-Tort P, Jonson C, Fulton-Howard B, et al
    The role of genomic-informed risk assessments in predicting dementia outcomes.
    Alzheimers Dement. 2025;21:e70826.
    PubMed         Abstract available

  3. COBURN MA, Eskandari-Sedighi G, Hasselmann J, England W, et al
    Human microglia differentially respond to beta-amyloid, tau, and combined Alzheimer's disease pathologies in vivo.
    Alzheimers Dement. 2025;21:e70930.
    PubMed         Abstract available

  4. GHANBARIAN E, Qian T, Khorsand B, Zheng L, et al
    Prognostic value of plasma glial fibrillary acidic protein in cognitively unimpaired older adults: Results from the A4 study.
    Alzheimers Dement. 2025;21:e70948.
    PubMed         Abstract available

  5. DACEY R, Hou L, Gurnani A, Han X, et al
    Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking.
    Alzheimers Dement. 2025;21:e70922.
    PubMed         Abstract available

  6. VAZQUEZ-OLIVER A, Perez-Garcia S, Romero-Perez R, Pizarro N, et al
    Targeting dysregulated CB1 receptors in a Down syndrome mouse model improves neurological outcomes.
    Alzheimers Dement. 2025;21:e70874.
    PubMed         Abstract available

  7. LIN A, Dai X, Chen J, Han T, et al
    ACLY regulates autolysosome acidification through tubulin acetylation-mediated assembly of V-ATPase subunits in Alzheimer's disease model mice.
    Alzheimers Dement. 2025;21:e70919.
    PubMed         Abstract available

  8. MACKEY-ALFONSO SE, Barrientos RM
    Neuroinflammatory mechanisms linking high-fat diets to Alzheimer's disease vulnerability: Beyond the amyloid hypothesis.
    Alzheimers Dement. 2025;21:e70911.
    PubMed         Abstract available

  9. HYMAN M, Chang S, Gong D, Chollet E, et al
    Mesoscopic vascular alterations in Alzheimer's disease.
    Alzheimers Dement. 2025;21:e70907.
    PubMed         Abstract available

  10. RAMIREZ P, Sun W, Dehkordi SK, Zare H, et al
    Long-read sequencing reveals genomic and epigenomic variation in the dark genome of human Alzheimer's disease.
    Alzheimers Dement. 2025;21:e70852.
    PubMed         Abstract available

  11. EISSMAN JM, Qiao M, Kalia V, Zerlin-Esteves M, et al
    Genetic regulation of the metabolome differs by sex, Alzheimer's disease stage, and plasma biomarker status.
    Alzheimers Dement. 2025;21:e70898.
    PubMed         Abstract available

  12. PALPATZIS E, Locascio JJ, Palmer P, Diez I, et al
    Adaptive stress coping is associated with cognitive resilience in at-risk cognitively unimpaired older adults.
    Alzheimers Dement. 2025;21:e70713.
    PubMed         Abstract available

  13. LEE EH, Huang YN, Park T, Liu S, et al
    Longitudinal plasma proteomics: relation to incident Alzheimer's disease dementia and biomarkers.
    Alzheimers Dement. 2025;21:e70900.
    PubMed         Abstract available


    Brain

  14. ZAMMIT MD, Bruzzone H, Cody KA, Morse J, et al
    The tau biomarker cascade is condensed in Down syndrome compared to sporadic Alzheimer's disease.
    Brain. 2025 Nov 15:awaf428. doi: 10.1093.
    PubMed         Abstract available


    Brain Res

  15. YUAN J, Zhang J, Zhang H, Tu Y, et al
    Propofol induces mitochondrial dysfunction in hippocampal neurons and postoperative cognitive dysfunction in male 3xTg-AD mice by blocking ESRRG-mediated HSD11B2 transcription.
    Brain Res. 2025;1869:150035.
    PubMed         Abstract available

  16. SHARMA A, Singh TG
    Next-generation neurotherapeutics: mechanistic insights on monoclonal antibodies in Alzheimer's disease.
    Brain Res. 2025;1870:150047.
    PubMed         Abstract available

  17. SARDARI M, Sahafi OH, Rezayof A
    Mitochondria serve as indispensable components of neuron-glia crosstalk in the trajectory of Alzheimer's disease.
    Brain Res. 2025 Nov 18:150040. doi: 10.1016/j.brainres.2025.150040.
    PubMed         Abstract available


    Dement Geriatr Cogn Disord

  18. WANG X, Shen Y, Lei C, Chai J, et al
    Comprehensive Bibliometric Analysis of P-Tau in Alzheimer's Disease: Trends and Emerging Research Priorities (1991-2024).
    Dement Geriatr Cogn Disord. 2025 Nov 20:1-20. doi: 10.1159/000549394.
    PubMed         Abstract available


    Exp Gerontol

  19. EBRAHIMI R, Salehi Amniyeh Khozani AA, Masouri MM, Seifi M, et al
    Neurodegeneration and glial activation related blood biomarkers in Alzheimer's disease: A systematic review and an updated meta- analysis.
    Exp Gerontol. 2025;212:112960.
    PubMed         Abstract available


    Exp Neurol

  20. HEATH AM, Mojabi FS, Kraybill EP, Beard C, et al
    Comparison of treatment schedules on cognitive effects of rTMS in the 3xTg-AD model of Alzheimer's disease.
    Exp Neurol. 2025;396:115551.
    PubMed         Abstract available

  21. ALTINDAG F, Bayir MH, Alhalboosi JKI, Yildizhan K, et al
    Syringic acid mitigates scopolamine-induced cognitive impairment by regulating PSD-95 and GSK-3beta and by preventing neurodegeneration in an Alzheimer-like rat model.
    Exp Neurol. 2025 Nov 17:115556. doi: 10.1016/j.expneurol.2025.115556.
    PubMed         Abstract available


    Int J Neurosci

  22. PAN Y, Zhu L, Wang ZL
    EEG spectral power differences in Alzheimer's disease and frontotemporal dementia.
    Int J Neurosci. 2025 Nov 21:1-9. doi: 10.1080/00207454.2025.2591129.
    PubMed         Abstract available


    J Alzheimers Dis

  23. VON SALZEN D, Senn K, Cho HK, Cahill CM, et al
    PROTEIMERs as catalytic inhibitors of APP mRNA translation: Toward a new therapeutic for Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 19:13872877251393907. doi: 10.1177/13872877251393907.
    PubMed         Abstract available

  24. WANG K, Zhu Y, Albert M, Miller M, et al
    Modeling the age-specific incidence of mild cognitive impairment incorporating the time-varying relationship of Alzheimer's disease biomarkers over 28 years.
    J Alzheimers Dis. 2025 Nov 19:13872877251393729. doi: 10.1177/13872877251393729.
    PubMed         Abstract available

  25. UCHEAGWU VA, Morgan D, Rose S, Odilora C, et al
    Alzheimer's Disease Biomarker-Nigeria (ADIBIO-N): Cohort description and baseline data report.
    J Alzheimers Dis. 2025 Nov 18:13872877251394384. doi: 10.1177/13872877251394384.
    PubMed         Abstract available

  26. GEORGESCU MF
    Agitation and neuropsychiatric symptoms in Alzheimer's disease: Potential for reverse causal associations.
    J Alzheimers Dis. 2025 Nov 17:13872877251396056. doi: 10.1177/13872877251396056.
    PubMed         Abstract available

  27. BRAMEN JE, Siddarth P, Popa ES, Kress GT, et al
    A multi-modal medical management and lifestyle intervention increase cerebral blood flow and lowers diabetic risk in persons with early Alzheimer's disease: Mid-trial results from the PREVENTION trial.
    J Alzheimers Dis. 2025 Nov 16:13872877251388933. doi: 10.1177/13872877251388933.
    PubMed         Abstract available


  28. Cyrus A. Raji, MD, PhD, is the recipient of the 2025 Mark A. Smith Alzheimer Award.
    J Alzheimers Dis. 2025;106:1217-1218.
    PubMed        


    J Biol Chem

  29. KATSINELOS T, Lovestam S, Qi C, Ryskeldi-Falcon B, et al
    Seeding biosensor cell line that reproduces the Alzheimer tau fold.
    J Biol Chem. 2025 Nov 17:110952. doi: 10.1016/j.jbc.2025.110952.
    PubMed         Abstract available


    Lancet Neurol

  30. RABINOVICI GD
    Progress in Alzheimer's disease: The Lancet Series.
    Lancet Neurol. 2025;24:991-992.
    PubMed        

  31. SCHOLZ SW, Okubadejo NU, Prakash P, Liddelow SA, et al
    Advances in the genetics and pathology of Lewy body dementia.
    Lancet Neurol. 2025;24:1026-1037.
    PubMed         Abstract available

  32. JACK CR JR, Hu M, Wiste HJ, Knopman DS, et al
    Lifetime and 10-year absolute risk of cognitive impairment in relation to amyloid PET severity: a retrospective, longitudinal cohort study.
    Lancet Neurol. 2025;24:1016-1025.
    PubMed         Abstract available


    Nat Med

  33. LIU Y, Gu X, Li Y, Wang F, et al
    Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function.
    Nat Med. 2025;31:3790-3800.
    PubMed         Abstract available


    Nat Neurosci

  34. ZHOU Y, Li WL, Liu ZQ, Ai WQ, et al
    Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.
    Nat Neurosci. 2025 Nov 18. doi: 10.1038/s41593-025-02137.
    PubMed         Abstract available


    Neurobiol Aging

  35. MCDERMOTT KE, Dieckhaus L, Comrie C, Sandrin V, et al
    Microstructural changes in locus coeruleus-cortical projections in aged bonnet macaques are independent of myelin loss.
    Neurobiol Aging. 2026;157:17-25.
    PubMed         Abstract available

  36. ANASTASI F, Genius P, Rodriguez-Fernandez B, Yang C, et al
    Proteomic polygenic risk scores of age-related plasma protein levels reveal a role for Metalloproteinase inhibitor 2 (TIMP2) in cognitive performance.
    Neurobiol Aging. 2026;157:68-78.
    PubMed         Abstract available

  37. TORREALBA-ACOSTA G, Yang S, Calvo-Marin J, Moghekar AR, et al
    Identifying a proteomics signature of cognitive impairment and dementia in blood and cerebrospinal fluid through a mediation analysis framework.
    Neurobiol Aging. 2026;157:79-88.
    PubMed         Abstract available


    Neurobiol Dis

  38. AUNG KZ, Zin SS, Wu X, Myint ZW, et al
    Disentangling the inverse relationship between cancer and Alzheimer's or Parkinson's disease: A systematic review on Mendelian randomization studies.
    Neurobiol Dis. 2025;217:107190.
    PubMed         Abstract available

  39. RAFIEE Z, Poceviciute D, Santiago J, Mahmoud R, et al
    CSF pTDP-43 across the Alzheimer's spectrum: Links to amyloid, APOE and vasculopathy.
    Neurobiol Dis. 2025;217:107193.
    PubMed         Abstract available


    Neurol Genet

  40. CHATTERJEE A, Cavailles C, Davies NM, Yaffe K, et al
    Disentangling the Causal Effects of Education and Participation Bias on Alzheimer Disease Using Mendelian Randomization.
    Neurol Genet. 2025;11:e200307.
    PubMed         Abstract available


    Neurology

  41. COUGHLIN DG, Jain L, Khrestian M, Bozoki AC, et al
    CSF alpha-Synuclein Seed Amplification Assays and Alzheimer Disease Biomarkers in Dementia With Lewy Bodies: Presentation and Progression.
    Neurology. 2025;105:e214346.
    PubMed         Abstract available


    PLoS One

  42. WARE EB, Zhu P, Noppert G, Fu M, et al
    Associations of perceived neighborhood factors and Alzheimer's disease polygenic score with cognition: Evidence from the Health and Retirement Study.
    PLoS One. 2025;20:e0336403.
    PubMed         Abstract available


    Proc Natl Acad Sci U S A

  43. AKHTER F, Akhter A, Zhu X, Schiff H, et al
    Amyloid-beta glycation induces neuronal mitochondrial dysfunction and Alzheimer's pathogenesis via VDAC1-dependent mtDNA efflux.
    Proc Natl Acad Sci U S A. 2025;122:e2505046122.
    PubMed         Abstract available


    Rev Neurol (Paris)

  44. WALLON D, Garnier-Crussard A
    The challenging concept of preclinical Alzheimer's disease.
    Rev Neurol (Paris). 2025;181:881-892.
    PubMed         Abstract available

  45. DUPONT S
    Late-onset epilepsy as a prodromal symptom.
    Rev Neurol (Paris). 2025;181:929-936.
    PubMed         Abstract available


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