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  Alzheimer's Disease

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10.08.2026

1 Acta Neuropathol
17 Alzheimers Dement
1 Ann Neurol
1 Br J Psychiatry
4 Brain
1 Brain Res
1 Exp Gerontol
13 J Alzheimers Dis
2 J Am Geriatr Soc
1 J Neural Transm (Vienna)
1 Nat Rev Neurol
1 Neurobiol Aging
1 Neurobiol Dis
4 Neurology
2 Neuroscience
1 PLoS One
2 Proc Natl Acad Sci U S A


  Retrieve available abstracts of this week’s articles:
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Single Articles


    Acta Neuropathol

  1. THIERRY M, Leitner D, Balcomb K, Kavanagh T, et al
    Proteomic comparison of hippocampal neurofibrillary tangles in PART, intermediate Alzheimer's disease and advanced Alzheimer's disease.
    Acta Neuropathol. 2026;152:13.
    PubMed         Abstract available


    Alzheimers Dement

  2. LYNCH SY, Wang Y, Wang D, Bachhav SS, et al
    A randomized phase 1b/2 trial of ABBV-916 in adults with early Alzheimer's disease.
    Alzheimers Dement. 2026;22:e71715.
    PubMed         Abstract available

  3. KOLLING LJ, Wang R, Gaudencio GS, Fishbeyn JS, et al
    Dorsal raphe tau pathology disrupts sleep-wake orchestration and sleep architecture in a sex-specific manner.
    Alzheimers Dement. 2026;22:e71687.
    PubMed         Abstract available

  4. COLLINS EC, Lu M, Beck R, Hendrix J, et al
    Plasma P-tau217 for detecting amyloid clearance after donanemab in Alzheimer's disease.
    Alzheimers Dement. 2026;22:e71740.
    PubMed         Abstract available

  5. OBLAK AL, Sasner M, Carter GW, Howell GR, et al
    The past, the present, and the future of preclinical mouse models for Alzheimer's disease and related dementias.
    Alzheimers Dement. 2026;22:e71741.
    PubMed         Abstract available

  6. ZHU X, Haure-Mirande JV, Bicak M, Dong P, et al
    miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models.
    Alzheimers Dement. 2026;22:e71684.
    PubMed         Abstract available

  7. GROENEVELD J, Perlaza D, Olive C, Grangeon L, et al
    APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome.
    Alzheimers Dement. 2026;22:e71738.
    PubMed         Abstract available

  8. EHRENBERG AJ, Falgas N, Jacobs HIL, Grinberg LT, et al
    Neuromodulatory subcortical systems in Alzheimer's disease.
    Alzheimers Dement. 2026;22:e71747.
    PubMed        

  9. MORADI K, Hadidchi R, Majbri A, Hughes TM, et al
    Temporalis muscle biomarkers from routine brain MRI and risk of dementia in two independent cohorts.
    Alzheimers Dement. 2026;22:e71622.
    PubMed         Abstract available

  10. OLAYINKA O, Farrell JJ, Zhu C, Khurshid Z, et al
    Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery.
    Alzheimers Dement. 2026;22:e71710.
    PubMed         Abstract available

  11. CARRIGAN M, Birkenbihl C, Klinger HM, Langford O, et al
    Sex specificity of resistance to caTAUstrophe.
    Alzheimers Dement. 2026;22:e71716.
    PubMed         Abstract available

  12. TRUDEL L, Therriault J, Macedo AC, Aumont E, et al
    Predicting continuous amyloid PET levels with CSF and plasma brain-derived p-tau217.
    Alzheimers Dement. 2026;22:e71723.
    PubMed         Abstract available

  13. BOUSTANI M, Klein EG, Zimmer JA, Wang H, et al
    Further data to address the Alzheimer's coverage with evidence development questions.
    Alzheimers Dement. 2026;22:e71724.
    PubMed         Abstract available

  14. FERNANDEZ-LEBRERO A, Jimenez-Balado J, Garcia-Escobar G, Contador J, et al
    Plasma p-tau217 detects Alzheimer's disease co-pathology in cerebral amyloid angiopathy: Comparison to CSF biomarkers in the ANGMAR cohort.
    Alzheimers Dement. 2026;22:e71709.
    PubMed         Abstract available

  15. HUTTEN CG, Beck T, Evans D, Rajan KB, et al
    The role of polygenic risk in Alzheimer's disease prediction for African Americans.
    Alzheimers Dement. 2026;22:e71712.
    PubMed         Abstract available

  16. WU H, Chen Q, Fang M, Tang H, et al
    Lecanemab use in Chinese patients with Alzheimer's disease: a 12-month multicenter real-world study.
    Alzheimers Dement. 2026;22:e71702.
    PubMed         Abstract available

  17. KIM BH, Lee H, Kim J, Seo SW, et al
    Epigenetic aging in Alzheimer's disease: Relation to proteome.
    Alzheimers Dement. 2026;22:e71732.
    PubMed         Abstract available

  18. MAESTRE GE, Patel NK, Pirela RV, Hilsabeck RC, et al
    Engagement of understudied populations as community change: The South Texas ADRC model.
    Alzheimers Dement. 2026;22:e71695.
    PubMed         Abstract available


    Ann Neurol

  19. PENA-TAUBER A, Hernandez Arriaza R, Reil D, Muntaner M, et al
    Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk.
    Ann Neurol. 2026 Aug 3. doi: 10.1002/ana.78303.
    PubMed         Abstract available


    Br J Psychiatry

  20. KOYCHEV I, Rowe JB, Amin J, Arsland D, et al
    Interpreting evolving evidence in Alzheimer's disease: implications for dementia clinicians.
    Br J Psychiatry. 2026 Aug 5:1-2. doi: 10.1192/bjp.2026.10750.
    PubMed        


    Brain

  21. PINI L, Imbimbo BP, Corbetta M
    Reply: The disconnectome as target in Alzheimer disease: a promising framework or a premature end-point?
    Brain. 2026 Aug 6:awag263. doi: 10.1093.
    PubMed        

  22. PALMER AM, Francis PT, Sims NR
    Fifty years of the cholinergic hypothesis: David Bowen's legacy in Alzheimer's disease.
    Brain. 2026 Aug 5:awag261. doi: 10.1093.
    PubMed        

  23. PIRAS F, Serra L, Caltagirone C, Giove F, et al
    The disconnectome as target in Alzheimer disease: a promising framework or a premature end-point?
    Brain. 2026 Aug 5:awag262. doi: 10.1093.
    PubMed        

  24. LONA-DURAZO F, Byrne RP, Pilon MO, Greicius MD, et al
    Sex-aware causal inference assessment of the immune system in complex neurodegenerative diseases.
    Brain. 2026;149:2716-2730.
    PubMed         Abstract available


    Brain Res

  25. WANG Y, Qin S, Gong X, Bai H, et al
    A promising therapeutic strategy reduces abnormal Abeta deposition and inhibits neuronal apoptosis via FGF17 ameliorating AD-like neurodegeneration.
    Brain Res. 2026;1889:150474.
    PubMed         Abstract available


    Exp Gerontol

  26. MUEDANO-SOSA A, Trujillo-Pineda M, Ruiz-Perez S, Cervera A, et al
    In silico analysis of transcriptomic datasets reveals nonlinear gene expression trajectories in aging microglia and Alzheimer's disease.
    Exp Gerontol. 2026;223:113263.
    PubMed         Abstract available


    J Alzheimers Dis

  27. LABBAD I, Youssef LA, Rustom M, Agha MS, et al
    APOE epsilon4 and late-onset Alzheimer's disease in Syria: A case-control study.
    J Alzheimers Dis. 2026 Aug 8:13872877261475340. doi: 10.1177/13872877261475340.
    PubMed         Abstract available

  28. VASSILAKI M, Smith SM, Loftin TM, Mohamed EA, et al
    Reflections on rural community characteristics by an outreach, recruitment, and engagement team.
    J Alzheimers Dis. 2026;112:1175-1181.
    PubMed         Abstract available

  29. FRANCO-MACIAS E, Noval-Padillo JA, Hervas-Navidad R, Espejo-Martinez B, et al
    Plasma p-tau217 measured by the Elecsys automated immunoassay: Prospective validation in a heterogeneous memory clinic cohort.
    J Alzheimers Dis. 2026;112:1470-1484.
    PubMed         Abstract available

  30. LEE S, Choi BJ, Park MH, Park S, et al
    A novel antibody against CD300c ameliorates cognitive deficits and reduces pathology in the late-stage of APP/PS1 mouse model.
    J Alzheimers Dis. 2026;112:1353-1361.
    PubMed         Abstract available

  31. ROYALL DR, Palmer RF
    Biomarker affliction classes contribute additively to observed dementia severity and prospective conversion risk.
    J Alzheimers Dis. 2026;112:1382-1392.
    PubMed         Abstract available

  32. BOUGES S, Alagoz E, Gutierrez-Meza D, Noell D, et al
    Engendering trustworthiness in the community: Strategies for researchers.
    J Alzheimers Dis. 2026;112:1459-1469.
    PubMed         Abstract available

  33. ZHANG J, Wang C, Liang C, Peng T, et al
    Neurolymphatic formula restores meningeal and peripheral lymphatic function via VEGFR3 activation: Mechanistic validation of coptisine as a key anti-Alzheimer's compound.
    J Alzheimers Dis. 2026 Aug 1:13872877261470114. doi: 10.1177/13872877261470114.
    PubMed         Abstract available

  34. CLEMENT G, Hansmannel F, Hopes L, Bossenmeyer-Pourie C, et al
    Alzheimer's disease and nutrition: Focus on the impact of hyperhomocysteinemia.
    J Alzheimers Dis. 2026 Aug 1:13872877261471813. doi: 10.1177/13872877261471813.
    PubMed         Abstract available

  35. LI L, Kenner E, Wan L, Yan Z, et al
    Reduced expression of Brain Expressed X-linked genes in Alzheimer's disease.
    J Alzheimers Dis. 2026 Aug 3:13872877261471446. doi: 10.1177/13872877261471446.
    PubMed         Abstract available

  36. QIU J, Zhang Y, Shang Y, Shang Q, et al
    Impact of SARS-CoV-2 infection on the progression of Alzheimer's disease: A prospective cohort study.
    J Alzheimers Dis. 2026 Aug 5:13872877261469118. doi: 10.1177/13872877261469118.
    PubMed         Abstract available

  37. KNOX S, Dooley M, Cutty M, Simpson KN, et al
    Beyond binary classification: A tiered claims-based algorithm for Alzheimer's disease and related dementias in Medicare.
    J Alzheimers Dis. 2026 Aug 5:13872877261471874. doi: 10.1177/13872877261471874.
    PubMed         Abstract available

  38. FATIMA SUK, Jabber A, Khanam MH, Khan J, et al
    Integrative machine learning reveals telomere-associated gene modules reflecting neuronal dysregulation in Alzheimer's disease.
    J Alzheimers Dis. 2026 Aug 8:13872877261476085. doi: 10.1177/13872877261476085.
    PubMed         Abstract available

  39. TIAN Y, Qing H, Quan Z
    A working feedback-based framework for goal-directed spatial memory deficits in Alzheimer's disease: Feedforward and feedback interactions along the RSC-MEC-CA1-RSC axis.
    J Alzheimers Dis. 2026 Aug 8:13872877261473933. doi: 10.1177/13872877261473933.
    PubMed         Abstract available


    J Am Geriatr Soc

  40. GHAHREMANI M, Smith EE, Ismail Z
    Reply to Comments on "Persistent Functional Impairment as an Early Indicator of Alzheimer's Disease Pathology and Progression".
    J Am Geriatr Soc. 2026 Aug 3. doi: 10.1111/jgs.70615.
    PubMed        

  41. JOYCE NR, Balog S, Gaither R, Pfeiffer MR, et al
    A Motor Vehicle Crash as an Early Signal of Alzheimer's Disease and Related Dementias.
    J Am Geriatr Soc. 2026 Aug 6. doi: 10.1111/jgs.70630.
    PubMed         Abstract available


    J Neural Transm (Vienna)

  42. DANYSZ W, Hansen N, Wiltfang J, Kornhuber J, et al
    Memantine: updates from the past decade and implications for future novel therapeutic applications.
    J Neural Transm (Vienna). 2026;133:1205-1277.
    PubMed         Abstract available


    Nat Rev Neurol

  43. LUCEY BP, Howell MJ
    Losing sleep over glia: new mechanisms for Alzheimer-related sleep disruption.
    Nat Rev Neurol. 2026 Aug 4. doi: 10.1038/s41582-026-01255.
    PubMed        


    Neurobiol Aging

  44. AALTONEN A, Palviainen T, Heikkinen S, Herukka SK, et al
    Genetic architecture of Alzheimer's disease-related plasma biomarkers.
    Neurobiol Aging. 2026;168:123-131.
    PubMed         Abstract available


    Neurobiol Dis

  45. RIFFO-LEPE N, Gonzalez-Sanmiguel J, Meza I, Saavedra-Sieyes P, et al
    Selective impairment of long-term depression in accumbal D1R+ MSNs involves calcium-permeable AMPARs in early Alzheimer's disease.
    Neurobiol Dis. 2026 Aug 7:107568. doi: 10.1016/j.nbd.2026.107568.
    PubMed         Abstract available


    Neurology

  46. KROPP E, Varkanitsa M, Stein TD, Turk K, et al
    Diagnostic Accuracy of the Boston Criteria v2.0 in Memory Clinic Patients: An MRI-Neuropathology Validation Study.
    Neurology. 2026;107:e218314.
    PubMed         Abstract available

  47. PRODAN CI, Yabluchanskiy A
    The Challenge of Atypical Alzheimer Disease Phenotypes.
    Neurology. 2026;107:e218533.
    PubMed        

  48. SHIR D, Corriveau-Lecavalier N, Jones DT, Ramanan VK, et al
    Eligibility for Anti-Amyloid Therapies in Patients With Biomarker-Confirmed Atypical Alzheimer Disease Phenotypes.
    Neurology. 2026;107:e218347.
    PubMed         Abstract available

  49. CASARINI A, Ballerini A, Maramotti R, Tondelli M, et al
    Cognitive and Biomarker Signatures of Late-Onset Temporal Lobe Epilepsy: Toward Non-Alzheimer Neurodegenerative Mechanisms.
    Neurology. 2026;107:e218356.
    PubMed         Abstract available


    Neuroscience

  50. CALON F, Otaegui L, Bouali ML, Hebert SS, et al
    Are mouse models of Alzheimer's disease truly flawed, or are we misusing them?
    Neuroscience. 2026;614:43-46.
    PubMed         Abstract available

  51. YADAV A, Verma H, Kumari S, Gangwar P, et al
    The emerging role of NADPH oxidases (NOX) in Alzheimer's disease pathogenesis.
    Neuroscience. 2026 Aug 6:S0306-4522(26)00533.
    PubMed         Abstract available


    PLoS One

  52. TAKEOKA C, Yada T, Yamazaki T, Kuroiwa Y, et al
    Classification of sporadic Creutzfeldt-Jakob disease based on resting state scalp-recorded electroencephalogram-derived indices.
    PLoS One. 2026;21:e0355367.
    PubMed         Abstract available


    Proc Natl Acad Sci U S A

  53. THANGAVEL M, Masurkar AV
    Nuclear garbage disposal: An unexpected role for amyloid precursor protein in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2026;123:e2619791123.
    PubMed        

  54. CHAUDHARI NN, Vega Huerta OM, Bhattacharya S, Chowdhury NF, et al
    Deep learning maps local brain aging in relation to cognition across human adulthood.
    Proc Natl Acad Sci U S A. 2026;123:e2532233123.
    PubMed         Abstract available


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