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  Alzheimer's Disease

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01.12.2025

1 Acta Neuropathol
5 Alzheimer Dis Assoc Disord
15 Alzheimers Dement
1 Am J Geriatr Psychiatry
2 BMC Neurol
2 Brain
1 Brain Res
1 Exp Gerontol
10 J Alzheimers Dis
2 J Biol Chem
1 J Neurochem
3 Nat Neurosci
1 Nat Rev Neurol
1 Neurochem Res
2 Neurology
1 Neurosci Lett


  Retrieve available abstracts of this week’s articles:
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Single Articles


    Acta Neuropathol

  1. IOANNOU K, Perrin RJ, Abdullaieva K, Bluma M, et al
    Neuropathologic correlates of cognitive impairment in Alzheimer's disease with discordant CSF biomarker profiles: co-pathologies in focus.
    Acta Neuropathol. 2025;150:57.
    PubMed         Abstract available


    Alzheimer Dis Assoc Disord

  2. HOULIHAN H, Guzman D, Smith A, Sanchez T, et al
    Neuroimaging Compendium of Microglia, Amyloid, Tau, and Neurodegeneration Across Clinical Variants of Alzheimer Disease.
    Alzheimer Dis Assoc Disord. 2025;39:315-319.
    PubMed         Abstract available

  3. DIAZ D, Kirk A, O'Connell M, Morgan D, et al
    Do Education and Premorbid Intelligence Predict Cognitive Decline Over 1 Year in Rural Patients with Dementia?
    Alzheimer Dis Assoc Disord. 2025;39:307-312.
    PubMed         Abstract available

  4. SMITH A, Guzman D, Lee S, Talmasov D, et al
    Inflammatory Alterations and Multidomain Cognition in Alzheimer Disease and Related Dementias.
    Alzheimer Dis Assoc Disord. 2025;39:181-190.
    PubMed         Abstract available

  5. GRAFF RE, Chen DM, Swinnerton KN, Ackley SF, et al
    Evaluation of Polygenic Risk Scores for a Possible Genetic Basis of the Inverse Association Between Cancer and Cognitive Decline.
    Alzheimer Dis Assoc Disord. 2025;39:235-243.
    PubMed         Abstract available

  6. TAN A, Wang Z, Aumont E, Li A, et al
    Determinants of Treatment Willingness and Willingness-to-Pay for Lecanemab in China: A Network Analysis.
    Alzheimer Dis Assoc Disord. 2025;39:223-230.
    PubMed         Abstract available


    Alzheimers Dement

  7. BOLTON CJ, Zhang P, Wilhoite SR, Moore EE, et al
    Increased neuroplastic activity in the pathogenesis of Alzheimer's disease.
    Alzheimers Dement. 2025;21:e70897.
    PubMed         Abstract available

  8. MANGALMURTI A, Zengeler KE, Hollis A, Golden E, et al
    Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease.
    Alzheimers Dement. 2025;21:e70943.
    PubMed         Abstract available

  9. BANIHASHEMI MA, Krance SH, Ji PX, Koo M, et al
    Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.
    Alzheimers Dement. 2025;21:e70884.
    PubMed         Abstract available

  10. GUGLIELMO S, Di Nardo N, Scantamburlo M, Mainardi M, et al
    Chemogenetic manipulation of learning-tagged neurons is sufficient to rescue progressive memory deficits in a mouse model of Alzheimer's disease.
    Alzheimers Dement. 2025;21:e70953.
    PubMed         Abstract available

  11. XU Y, Qiao M, Gunasekaran TI, Gu Y, et al
    Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change.
    Alzheimers Dement. 2025;21:e70937.
    PubMed         Abstract available

  12. LA JOIE R, Cummings JL, Dage JL, Galasko D, et al
    Treatment-related amyloid clearance (TRAC): a framework to characterize patients in the era of anti-amyloid therapies.
    Alzheimers Dement. 2025;21:e70997.
    PubMed         Abstract available

  13. LI Y, Liu W, Wang X, Qin W, et al
    Effect of SSRIs on clinical progression in amnestic mild cognitive impairment stratified by Alzheimer's disease pathology.
    Alzheimers Dement. 2025;21:e70946.
    PubMed         Abstract available

  14. MENTA BW, Schueddig E, Ranjan A, Li Y, et al
    MtDNA-depleted neuronal cell transcriptomes reveal Alzheimer's disease-related changes.
    Alzheimers Dement. 2025;21:e70929.
    PubMed         Abstract available

  15. TU YY, Cui L, Zhang Z, Wang M, et al
    Subjective sleep characteristics in non-demented adults: domain-specific associations with multimodal Alzheimer's disease biomarkers.
    Alzheimers Dement. 2025;21:e70932.
    PubMed         Abstract available

  16. HUMBLET-BARON S, Feng Y, Veiga R, Neumann J, et al
    A systems immunology analysis of Alzheimer's disease reveals an age- and environmental exposure-independent disturbance in B cell maturation.
    Alzheimers Dement. 2025;21:e70952.
    PubMed         Abstract available

  17. UM YH, Wynveen P, Holland M, Bhatt K, et al
    Neuroimaging correlates and biomarker performance of a fully automated plasma p-tau217/Abeta42 ratio assay in a clinical cohort with Alzheimer's disease.
    Alzheimers Dement. 2025;21:e70942.
    PubMed         Abstract available

  18. BALOGUN WG, Zeng X, Triana-Baltzer G, Saeed A, et al
    Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in predominantly cognitively normal community studies.
    Alzheimers Dement. 2025;21:e70916.
    PubMed         Abstract available

  19. INTZANDT B, Ramirez J, Lam B, Masellis M, et al
    Exploring sex-specific risk factors in cognitive decline: Insights into modifiable and non-modifiable determinants using a network analysis.
    Alzheimers Dement. 2025;21:e70825.
    PubMed         Abstract available

  20. KANG S, Jeon S, Kim Y, Jeon SH, et al
    Putaminal hypermetabolism identifies Lewy body co-pathology in Alzheimer's disease.
    Alzheimers Dement. 2025;21:e70920.
    PubMed         Abstract available

  21. KUEHN JF, Zhang Q, Heston MB, Kang JW, et al
    Fecal short-chain fatty acids vary by sex and amyloid status.
    Alzheimers Dement. 2025;21:e70877.
    PubMed         Abstract available


    Am J Geriatr Psychiatry

  22. ZIDE BS, Gagliardi G, Jacobs HIL, Gatchel JR, et al
    Living Alone, Early Tau Pathology, and Loneliness in Cognitively Unimpaired Older Adults During the COVID-19 Pandemic.
    Am J Geriatr Psychiatry. 2026;34:57-69.
    PubMed         Abstract available


    BMC Neurol

  23. WU M, Gao L, Su Q, Wang H, et al
    Global burden, spatiotemporal disparities, and sex-specific trends of early- and late-onset Alzheimer's disease and other dementias: a comparative analysis and projections to 2035.
    BMC Neurol. 2025 Nov 24. doi: 10.1186/s12883-025-04530.
    PubMed         Abstract available

  24. BASTAN F, Saeedi-Moghaddam F, Rashidian M, Mirhosseini F, et al
    Human herpesvirus 6 (HHV-6) infection and risk of Alzheimer's disease: a systematic review and meta-analysis.
    BMC Neurol. 2025 Nov 22. doi: 10.1186/s12883-025-04500.
    PubMed         Abstract available


    Brain

  25. KIM B, Yuk M, Park M, Ryu H, et al
    CRISPR editing of miR-33 restores ApoE lipidation and amyloid-beta metabolism in ApoE4 sporadic Alzheimer's disease.
    Brain. 2025 Nov 25:awaf244. doi: 10.1093.
    PubMed         Abstract available

  26. PINI L, Allali G, Imbimbo BP, Germani M, et al
    Brain connectivity as a new target for Alzheimer's disease therapy?
    Brain. 2025 Nov 28:awaf404. doi: 10.1093.
    PubMed         Abstract available


    Brain Res

  27. HUI S, Long Y, Zhu L, Shi W, et al
    IGF2BP2-mediated m6A modification of IGF1R mRNA promotes neuronal senescence and cognitive decline in Alzheimer's disease.
    Brain Res. 2025;1871:150067.
    PubMed         Abstract available


    Exp Gerontol

  28. CHEN PH, Lin SI, Liao YY, Hu GC, et al
    Plasma Alzheimer's biomarkers and physical functions in aging adults with and without motoric cognitive risk syndrome.
    Exp Gerontol. 2025;212:112975.
    PubMed         Abstract available


    J Alzheimers Dis

  29. VIADA C, Fors M, Capote E, Santiesteban Y, et al
    Bayesian predictive probability for binary outcomes in neurodegenerative diseases.
    J Alzheimers Dis. 2025;108:1222-1230.
    PubMed         Abstract available

  30. SATO K, Ihara R, Niimi Y, Suzuki K, et al
    Property difference in Mini-Mental State Examination Serial Sevens and World Backwards: Analysis using item response theory.
    J Alzheimers Dis. 2025;108:1015-1022.
    PubMed         Abstract available

  31. D'ANSELMO A, Prete G, Di Crosta A, Bristot L, et al
    Increased pre-alpha functional connectivity in dementia with Lewy bodies.
    J Alzheimers Dis. 2025;108:1132-1143.
    PubMed         Abstract available

  32. WU X, Tsuchiya I, Aung KZ, Qiao Q, et al
    Genetic association analyses of cognitive performance across multi-ancestry older adults: Application of Tobit models.
    J Alzheimers Dis. 2025;108:1312-1327.
    PubMed         Abstract available


  33. Corrigendum to 'Autoantibodies in Alzheimer's disease: Multifaceted roles and therapeutic horizons'.
    J Alzheimers Dis. 2025 Nov 24:13872877251401326. doi: 10.1177/13872877251401326.
    PubMed        

  34. PANZA F, Lozupone M, Resta E, Quarto S, et al
    Gustatory dysfunction and oral frailty: Emerging implications for Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 24:13872877251392552. doi: 10.1177/13872877251392552.
    PubMed         Abstract available

  35. AFRIDI MA, Khalid MM, Din RU
    Multi-modal approaches to Alzheimer's disease diagnosis: Combining cognitive assessments with biomarkers and imaging.
    J Alzheimers Dis. 2025 Nov 24:13872877251394315. doi: 10.1177/13872877251394315.
    PubMed         Abstract available

  36. CHACON T, Hernandez-Hincapie H
    Relationship periodontitis and Alzheimer's disease: Relevant aspects from an epigenetic view.
    J Alzheimers Dis. 2025 Nov 26:13872877251397406. doi: 10.1177/13872877251397406.
    PubMed         Abstract available

  37. USHER MR, Aybar-Torres AA, Jin L
    Identification of common human TMEM173 genotypes associated with Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 27:13872877251396973. doi: 10.1177/13872877251396973.
    PubMed         Abstract available

  38. ZHOU W, Lin H, Huang X, Zhou X, et al
    Identification and validation of PANoptosis-related genes in Alzheimer's disease.
    J Alzheimers Dis. 2025 Nov 27:13872877251396927. doi: 10.1177/13872877251396927.
    PubMed         Abstract available


    J Biol Chem

  39. ZHANG DY, Wang J, Huang G, Dokholyan M, et al
    Apolipoprotein E (APOE) regulates the transport of monosialotetrahexosylganglioside (GM1).
    J Biol Chem. 2025;301:110778.
    PubMed         Abstract available

  40. LUNDIN B, Wieckiewicz N, Yokomizo M, Sadek M, et al
    APP family is a regulator of endo-lysosomal membrane vulnerability.
    J Biol Chem. 2025;301:110774.
    PubMed         Abstract available


    J Neurochem

  41. PEREZ-RAMIREZ R, Cuchillo-Ibanez I, Sanchez-Romero R, Beltran-Sanahuja A, et al
    Development and Validation of an ICP-MS/MS Method for the Multielemental Analysis of Cerebrospinal Fluid, Examination of Alzheimer's Disease Samples.
    J Neurochem. 2025;169:e70307.
    PubMed         Abstract available


    Nat Neurosci

  42. JIN M, Ma Z, Dang R, Zhang H, et al
    A myeloid trisomy 21-associated gene variant is protective from Alzheimer's disease.
    Nat Neurosci. 2025 Nov 24. doi: 10.1038/s41593-025-02117.
    PubMed         Abstract available

  43. ALBERTINI G, Zielonka M, Cuypers ML, Snellinx A, et al
    The Alzheimer's therapeutic Lecanemab attenuates Abeta pathology by inducing an amyloid-clearing program in microglia.
    Nat Neurosci. 2025 Nov 24. doi: 10.1038/s41593-025-02125.
    PubMed         Abstract available

  44. CHOI DJ, Murali S, Kwon W, Woo J, et al
    Astrocytic Sox9 overexpression in Alzheimer's disease mouse models promotes Abeta plaque phagocytosis and preserves cognitive function.
    Nat Neurosci. 2025 Nov 21. doi: 10.1038/s41593-025-02115.
    PubMed         Abstract available


    Nat Rev Neurol

  45. BROWN GC, St George-Hyslop P, Paolicelli RC, Lemke G, et al
    Microglial phagocytosis in Alzheimer disease.
    Nat Rev Neurol. 2025 Nov 28. doi: 10.1038/s41582-025-01162.
    PubMed         Abstract available


    Neurochem Res

  46. WANG M, Zeng Y, Jin Y, Wu J, et al
    Progress and Perspectives on the Estrogen-Microbiota-Brain Axis in Alzheimer's Disease.
    Neurochem Res. 2025;51:3.
    PubMed         Abstract available


    Neurology

  47. FILIPPI M, Cecchetti G
    Choroid Plexus Morphology in Alzheimer Disease: Bridging Pathology and Cognition.
    Neurology. 2025;105:e214017.
    PubMed        

  48. LIN M, Zeng Q, Zhong S, Nie S, et al
    Association Between Choroid Plexus Morphological Alterations, Alzheimer Pathologies, and Cognitive Impairment: A Longitudinal Study.
    Neurology. 2025;105:e213953.
    PubMed         Abstract available


    Neurosci Lett

  49. PRATAP GK, Pramoda GN, Joshi CG, Sannegowda LK, et al
    Structure-function characterization of olea dioica PGK-1: Acetylcholinesterase inhibition, molecular docking, and amelioration of Abeta42-induced toxicity in SH-SY5Y neuronal cells and the UAS-Abeta(42); ey-GAL4 drosophila model of Alzheimer's disease
    Neurosci Lett. 2025 Nov 26:138467. doi: 10.1016/j.neulet.2025.138467.
    PubMed        


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