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Articles published in J Neurosci

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    April 2021
  1. VAN SKIKE CE, Hussong SA, Hernandez SF, Banh AQ, et al
    mTOR attenuation with rapamycin reverses neurovascular uncoupling and memory deficits in mice modeling Alzheimer's disease.
    J Neurosci. 2021 Apr 20. pii: JNEUROSCI.2144-20.2021.
    PubMed     Abstract available


    February 2021
  2. SANCHEZ-AGUILERA A, Quintanilla JP
    Sharp Wave Ripples in Alzheimer's Disease: In Search of Mechanisms.
    J Neurosci. 2021;41:1366-1370.
    PubMed    


  3. RIVERS-AUTY J, Tapia VS, White CS, Daniels MJ, et al
    Zinc status alters Alzheimer's disease progression through NLRP3-dependent inflammation.
    J Neurosci. 2021 Feb 16. pii: JNEUROSCI.1980-20.2020.
    PubMed     Abstract available


    November 2020
  4. FRACASSI A, Marcatti M, Zolochevska O, Tabor N, et al
    Oxidative damage and antioxidant response in frontal cortex of demented and non-demented individuals with Alzheimer's neuropathology.
    J Neurosci. 2020 Nov 24. pii: JNEUROSCI.0295-20.2020.
    PubMed     Abstract available


    October 2020
  5. ALBRECHT D, Isenberg AL, Stradford J, Monreal T, et al
    Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid.
    J Neurosci. 2020;40:8573-8586.
    PubMed     Abstract available



  6. Erratum: Forny-Germano et al., "Alzheimer's Disease-Like Pathology Induced by Amyloid-beta Oligomers in Nonhuman Primates".
    J Neurosci. 2020 Oct 6. pii: JNEUROSCI.1827-20.2020.
    PubMed    


    September 2020
  7. CHEN W, Wang M, Zhu M, Xiong W, et al
    14,15-epoxyeicosatrienoic acid alleviates pathology in a mouse model of Alzheimer's disease.
    J Neurosci. 2020 Sep 24. pii: JNEUROSCI.1246-20.2020.
    PubMed     Abstract available


  8. ZHANG H, Lin A, Gong P, Chen Y, et al
    The Chemokine-like Receptor 1 Deficiency Improves Cognitive Deficits of AD Mice and Attenuates Tau Hyperphosphorylation via Regulating Tau Seeding.
    J Neurosci. 2020;40:6991-7007.
    PubMed     Abstract available


    August 2020
  9. GHALAYINI J
    Exploring the Therapeutic Potential of Protein Tyrosine Phosphatase 1B in hAPP-J20 Mouse Model of Alzheimer's Disease.
    J Neurosci. 2020;40:6100-6102.
    PubMed    


    July 2020
  10. ZHANG H, Chen W, Tan Z, Zhang L, et al
    A Role of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytic Abeta Clearance.
    J Neurosci. 2020;40:5347-5361.
    PubMed     Abstract available


    May 2020
  11. SHEYNIN Y, Rosa-Neto P, Hess RF, Vaucher E, et al
    Cholinergic modulation of binocular vision.
    J Neurosci. 2020 May 25. pii: JNEUROSCI.2484-19.2020.
    PubMed     Abstract available


  12. CACCAVANO A, Bozzelli PL, Forcelli PA, Pak DTS, et al
    Inhibitory parvalbumin basket cell activity is selectively reduced during hippocampal sharp wave ripples in a mouse model of familial Alzheimer's disease.
    J Neurosci. 2020 May 21. pii: JNEUROSCI.0425-20.2020.
    PubMed     Abstract available


    April 2020
  13. SHIMOJO M, Takuwa H, Takado Y, Tokunaga M, et al
    Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.
    J Neurosci. 2020;40:3491-3501.
    PubMed     Abstract available


    February 2020
  14. ONUSKA KM
    The Dual Role of Microglia in the Progression of Alzheimer's Disease.
    J Neurosci. 2020;40:1608-1610.
    PubMed    


    January 2020
  15. MEILANDT WJ, Ngu H, Gogineni A, Lalehzadeh G, et al
    Trem2 deletion reduces late-stage amyloid plaque accumulation, elevates the Abeta42:Abeta40 ratio, and exacerbates axonal dystrophy and dendritic spine loss in the PS2APP Alzheimer's mouse model.
    J Neurosci. 2020 Jan 24. pii: JNEUROSCI.1871-19.2019.
    PubMed     Abstract available


  16. SCHMITZ TW, Soreq H, Poirier J, Spreng RN, et al
    Longitudinal basal forebrain degeneration interacts with TREM2/C3 biomarkers of inflammation in pre-symptomatic Alzheimer's disease.
    J Neurosci. 2020 Jan 8. pii: JNEUROSCI.1184-19.2019.
    PubMed     Abstract available


  17. RICKE KM, Cruz SA, Qin Z, Farrokhi K, et al
    Neuronal Protein Tyrosine Phosphatase 1B hastens Amyloid beta-associated Alzheimer's disease in mice.
    J Neurosci. 2020 Jan 8. pii: JNEUROSCI.2120-19.2019.
    PubMed     Abstract available


    December 2019
  18. FAN Q, He W, Gayen M, Robert Benoit M, et al
    Activated CX3CL1/Smad2 signals prevent neuronal loss and Alzheimer's tau pathology-mediated cognitive dysfunction.
    J Neurosci. 2019 Dec 10. pii: JNEUROSCI.1333-19.2019.
    PubMed     Abstract available


  19. CHENG A, Wang J, Ghena N, Zhao Q, et al
    SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model.
    J Neurosci. 2019 Dec 9. pii: JNEUROSCI.1446-19.2019.
    PubMed     Abstract available


    October 2019
  20. LEI M, Teo JD, Song H, McEwen HP, et al
    Sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of Alzheimer's disease.
    J Neurosci. 2019 Oct 21. pii: JNEUROSCI.0524-19.2019.
    PubMed     Abstract available


    September 2019
  21. SINGH A, Jones OD, Mockett BG, Ohline SM, et al
    Tumor Necrosis Factor-alpha-Mediated Metaplastic Inhibition of LTP is Constitutively Engaged in an Alzheimer's Disease Model.
    J Neurosci. 2019 Sep 30. pii: JNEUROSCI.1492-19.2019.
    PubMed     Abstract available


  22. BONDS JA, Shetti A, Bheri A, Chen Z, et al
    Depletion of Caveolin-1 in Type-2 Diabetes Model Induces Alzheimer's disease Pathology Precursors.
    J Neurosci. 2019 Sep 16. pii: JNEUROSCI.0730-19.2019.
    PubMed     Abstract available


    July 2019
  23. MARTINEZ-MARMOL R, Mohannak N, Qian L, Wang T, et al
    p110delta PI 3-kinase inhibition perturbs APP and TNFalpha trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model.
    J Neurosci. 2019 Jul 30. pii: JNEUROSCI.0674-19.2019.
    PubMed     Abstract available


  24. HANNA KRANCE S, Cogo-Moreira H, Rabin J, Elizabeth Black S, et al
    Reciprocal predictive relationships between amyloid and tau biomarkers in Alzheimer's disease progression; an empirical model.
    J Neurosci. 2019 Jul 26. pii: JNEUROSCI.1056-19.2019.
    PubMed     Abstract available


  25. HUANG YA, Zhou B, Nabet AM, Wernig M, et al
    Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.
    J Neurosci. 2019 Jul 22. pii: JNEUROSCI.2994-18.2019.
    PubMed     Abstract available


  26. PASSAMONTI L, Tsvetanov KA, Jones PS, Bevan-Jones WR, et al
    Neuroinflammation and functional connectivity in Alzheimer's disease: interactive influences on cognitive performance.
    J Neurosci. 2019 Jul 18. pii: JNEUROSCI.2574-18.2019.
    PubMed     Abstract available


    June 2019
  27. SPIERS JG, Chen HC
    Chronic Sleep Disruption Potentiates Locus Ceruleus Tauopathy in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2019;39:4844-4846.
    PubMed    


  28. ORTEGA-MARTINEZ S, Palla N, Zhang X, Lipman E, et al
    Deficits in Enrichment-Dependent neurogenesis and enhanced Anxiety behaviors mediated by expression of Alzheimer's disease-linked PS1 variants are rescued by Microglial Depletion.
    J Neurosci. 2019 Jun 19. pii: JNEUROSCI.0884-19.2019.
    PubMed     Abstract available


    April 2019
  29. FLECK D, Phu L, Verschueren E, Hinkle T, et al
    PTCD1 is required for mitochondrial oxidative-phosphorylation: possible genetic association with Alzheimer's disease.
    J Neurosci. 2019 Apr 4. pii: JNEUROSCI.0116-19.2019.
    PubMed     Abstract available


    March 2019
  30. VIANA DA SILVA S, Zhang P, Georg Haberl M, Labrousse V, et al
    Hippocampal mossy fibers synapses in CA3 pyramidal cells are altered at an early stage in a mouse model of Alzheimer's disease.
    J Neurosci. 2019 Mar 18. pii: JNEUROSCI.2868-18.2019.
    PubMed     Abstract available


  31. ALONI E, Oni-Biton E, Tsoory M, Moallem DH, et al
    Synaptopodin deficiency ameliorates symptoms in the 3xTg mouse model of Alzheimer's disease.
    J Neurosci. 2019 Mar 14. pii: JNEUROSCI.2920-18.2019.
    PubMed     Abstract available


    January 2019
  32. DE PINS B, Cifuentes-Diaz C, Thamila Farah A, Lopez-Molina L, et al
    Conditional BDNF delivery from astrocytes rescues memory deficits, spine density and synaptic properties in the 5xFAD mouse model of Alzheimer disease.
    J Neurosci. 2019 Jan 30. pii: JNEUROSCI.2121-18.2019.
    PubMed     Abstract available


  33. HUIJBERS W, Schultz AP, Papp KV, LaPoint MR, et al
    Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity.
    J Neurosci. 2019;39:548-556.
    PubMed     Abstract available


  34. MELO HM
    Potential Effects of Aspirin on Lysosomal Biogenesis and Amyloid-beta Clearance: An Old Drug and Novel Insights in Alzheimer's Disease Therapy.
    J Neurosci. 2019;39:197-198.
    PubMed    


    December 2018
  35. SALAZAR SV, Cox TO, Lee S, Brody AH, et al
    Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-beta Induced Synaptic Dysfunction and Loss.
    J Neurosci. 2018 Dec 5. pii: JNEUROSCI.1873-18.2018.
    PubMed     Abstract available


    October 2018
  36. CAMARA H, De-Souza EA
    beta-Amyloid Accumulation Slows Earlier than Expected in Preclinical Alzheimer's Disease Patients.
    J Neurosci. 2018;38:9123-9125.
    PubMed    


  37. RUSH T, Martinez-Hernandez J, Dollmeyer M, Lise Frandemiche M, et al
    Synaptotoxicity in Alzheimer's disease involved a dysregulation of actin cytoskeleton dynamics through cofilin 1 phosphorylation.
    J Neurosci. 2018 Oct 19. pii: JNEUROSCI.1409-18.2018.
    PubMed     Abstract available


    September 2018
  38. GWON Y, Kam TI, Kim SH, Song S, et al
    TOM1 regulates neuronal accumulation of amyloid-beta oligomers by FcgammaRIIb2 variant in Alzheimer's disease.
    J Neurosci. 2018 Sep 5. pii: JNEUROSCI.1996-17.2018.
    PubMed     Abstract available


    July 2018
  39. CHANDRA S, Jana M, Pahan K
    Aspirin induces Lysosomal biogenesis and attenuates Amyloid plaque pathology in a mouse model of Alzheimer's disease via PPARalpha.
    J Neurosci. 2018 Jul 2. pii: JNEUROSCI.0054-18.2018.
    PubMed     Abstract available


  40. WU L, Zhang X, Zhao L
    Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention.
    J Neurosci. 2018 Jul 2. pii: JNEUROSCI.2262-17.2018.
    PubMed     Abstract available


    June 2018
  41. SANJARI MOGHADDAM H, Aarabi MH
    Abeta-Mediated Dysregulation of F-Actin Nanoarchitecture Leads to Loss of Dendritic Spines and Alzheimer's Disease-Related Cognitive Impairments.
    J Neurosci. 2018;38:5840-5842.
    PubMed    


    March 2018
  42. RAJENDRAN L, Paolicelli RC
    Microglia-Mediated Synapse Loss in Alzheimer's Disease.
    J Neurosci. 2018;38:2911-2919.
    PubMed     Abstract available


  43. VANDERHEYDEN WM, Lim MM, Musiek ES, Gerstner JR, et al
    Alzheimer's Disease and Sleep-Wake Disturbances: Amyloid, Astrocytes, and Animal Models.
    J Neurosci. 2018;38:2901-2910.
    PubMed     Abstract available


    February 2018
  44. LIMA-FILHO RAS, Oliveira MM
    A Role for Cellular Prion Protein in Late-Onset Alzheimer's Disease: Evidence from Preclinical Studies.
    J Neurosci. 2018;38:2146-2148.
    PubMed    


    January 2018
  45. MUELLER MC, Baranowski BJ, Hayward GC
    New Insights on the Role of Residue 673 of APP in Alzheimer's Disease.
    J Neurosci. 2018;38:515-517.
    PubMed    


    December 2017
  46. PEERA KOMMADDI R, Das D, Karunakaran S, Nanguneri S, et al
    Abeta mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease.
    J Neurosci. 2017 Dec 15. pii: JNEUROSCI.2127-17.2017.
    PubMed     Abstract available


  47. WANG Z, Jackson RJ, Hong W, Taylor WM, et al
    Human Brain-Derived Abeta Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.
    J Neurosci. 2017;37:11947-11966.
    PubMed     Abstract available


    November 2017
  48. VAN DIJKEN I, van der Vlag M, Flores Hernandez R, Ross A, et al
    Perspectives on Treatment of Alzheimer's Disease: A Closer Look into EphB2 Depletion.
    J Neurosci. 2017;37:11296-11297.
    PubMed    


  49. RAY A, Speese SD, Logan MA
    Glial Draper rescues Abeta toxicity in a Drosophila model of Alzheimer's Disease.
    J Neurosci. 2017 Nov 6. pii: 0862-17. doi: 10.1523/JNEUROSCI.0862-17.2017.
    PubMed     Abstract available


  50. PARENT MJ, Zimmer ER, Shin M, Kang MS, et al
    Multimodal imaging in rat model recapitulates Alzheimer's Disease biomarkers abnormalities.
    J Neurosci. 2017 Nov 2. pii: 1346-17. doi: 10.1523/JNEUROSCI.1346-17.2017.
    PubMed     Abstract available


    October 2017
  51. NAKAZATO R, Kawabe K, Yamada D, Ikeno S, et al
    Disruption of Bmal1 Impairs Blood-Brain Barrier Integrity via Pericyte Dysfunction.
    J Neurosci. 2017;37:10052-10062.
    PubMed     Abstract available


  52. BANKS RA, Gibbons GS, Kim B, Xu H, et al
    GFP-mutant human tau transgenic mice develop tauopathy following CNS injections of Alzheimer's brain-derived pathological tau or synthetic mutant human tau fibrils.
    J Neurosci. 2017 Oct 6. pii: 2393-17. doi: 10.1523/JNEUROSCI.2393-17.2017.
    PubMed     Abstract available


    August 2017
  53. SUSS P
    Remote Control: Impacts of Peripheral Tumor Necrosis Factor-Alpha on Alzheimer Disease-Related Pathology.
    J Neurosci. 2017;37:8045-8047.
    PubMed    


  54. SALAZAR SV, Gallardo C, Kaufman AC, Herber CS, et al
    Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease.
    J Neurosci. 2017 Aug 21. pii: 0722-17. doi: 10.1523/JNEUROSCI.0722-17.2017.
    PubMed     Abstract available


  55. LI Y, Chen Z, Gao Y, Pan G, et al
    Synaptic adhesion molecule Pcdh-gammaC5 mediates synaptic dysfunction in Alzheimer's disease.
    J Neurosci. 2017 Aug 21. pii: 1051-17. doi: 10.1523/JNEUROSCI.1051-17.2017.
    PubMed     Abstract available


  56. CAPRELLI MT
    Regulation of Synaptic Amyloid-beta Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2017;37:7291-7293.
    PubMed    


    June 2017
  57. SOMPOL P, Furman JL, Pleiss MM, Kraner SD, et al
    Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Abeta-Bearing Mice.
    J Neurosci. 2017;37:6132-6148.
    PubMed     Abstract available


  58. ZHANG S, Wang Z, Cai F, Zhang M, et al
    BACE1 cleavage site selection critical for amyloidogenesis and Alzheimer's pathogenesis.
    J Neurosci. 2017 Jun 16. pii: 0340-17. doi: 10.1523/JNEUROSCI.0340-17.2017.
    PubMed     Abstract available


  59. DINIZ LP, Tortelli V, Matias I, Morgado J, et al
    Astrocyte transforming growth factor beta 1 protects synapses against Abeta oligomers in Alzheimer's disease model.
    J Neurosci. 2017 Jun 12. pii: 3351-16. doi: 10.1523/JNEUROSCI.3351-16.2017.
    PubMed     Abstract available


    May 2017
  60. PAOURI E, Tzara O, Kartalou GI, Zenelak S, et al
    Peripheral Tumor Necrosis Factor-Alpha (TNF-alpha) Modulates Amyloid Pathology by Regulating Blood-Derived Immune Cells and Glial Response in the Brain of AD/TNF Transgenic Mice.
    J Neurosci. 2017;37:5155-5171.
    PubMed     Abstract available


  61. SELLES MC, Fortuna JTS, Santos LE
    Immunomodulation via Toll-like Receptor 9: An Adjunct Therapy Strategy against Alzheimer's Disease?
    J Neurosci. 2017;37:4864-4867.
    PubMed    


  62. ROYEA J, Zhang L, Tong XK, Hamel E, et al
    Angiotensin IV receptors mediate the cognitive and cerebrovascular benefits of losartan in a mouse model of Alzheimer's disease.
    J Neurosci. 2017 May 5. pii: 0329-17. doi: 10.1523/JNEUROSCI.0329-17.2017.
    PubMed     Abstract available


    April 2017
  63. GAMAGE KK, Kumar S
    Aducanumab Therapy Ameliorates Calcium Overload in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2017;37:4430-4432.
    PubMed    


  64. BAEK SH, Park SJ, In Jeong J, Hyun Kim S, et al
    Inhibition of Drp1 Ameliorates Synaptic Depression, Abeta Deposition and Cognitive Impairment in Alzheimer's Disease Model.
    J Neurosci. 2017 Apr 21. pii: 2385-16. doi: 10.1523/JNEUROSCI.2385-16.2017.
    PubMed     Abstract available


    March 2017
  65. GRATTON C, Yousef S, Aarts E, Wallace DL, et al
    Cholinergic, but not dopaminergic or noradrenergic, enhancement sharpens visual spatial perception in humans.
    J Neurosci. 2017 Mar 23. pii: 2405-16. doi: 10.1523/JNEUROSCI.2405-16.2017.
    PubMed     Abstract available


    February 2017
  66. YE X, Feng T, Tammineni P, Chang Q, et al
    Regulation of Synaptic Abeta Generation Through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2017 Feb 3. pii: 2851-16. doi: 10.1523/JNEUROSCI.2851-16.2017.
    PubMed     Abstract available


    January 2017
  67. ZHANG ZH, Wu QY, Zheng R, Chen C, et al
    Selenomethionine mitigates cognitive decline by targeting both tau hyperphosphorylation and autophagic clearance in an Alzheimer's disease mouse model.
    J Neurosci. 2017 Jan 30. pii: 3229-16. doi: 10.1523/JNEUROSCI.3229-16.2017.
    PubMed     Abstract available


  68. JAY TR, Hirsch AM, Broihier ML, Miller CM, et al
    Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2017;37:637-647.
    PubMed     Abstract available


  69. VIEIRA MN, Beckman D
    Training Microglia to Resist Alzheimer's Disease.
    J Neurosci. 2017;37:477-479.
    PubMed    


  70. DATTA D
    APP Modulates Abeta-Induced Activation of Microglia in Mouse Model of Alzheimer's Disease.
    J Neurosci. 2017;37:238-240.
    PubMed    


  71. YANG T, Li S, Xu H, Walsh DM, et al
    Large Soluble Oligomers of Amyloid beta-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate.
    J Neurosci. 2017;37:152-163.
    PubMed     Abstract available


    December 2016
  72. PRIETO GA, Trieu BH, Dang CT, Bilousova T, et al
    Pharmacological rescue of long-term potentiation in Alzheimer diseased synapses.
    J Neurosci. 2016 Dec 16. pii: 2774.
    PubMed     Abstract available


  73. JAY TR, Hirsch AM, Broihier ML, Miller CM, et al
    Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease.
    J Neurosci. 2016 Dec 9. pii: 2110.
    PubMed     Abstract available


    November 2016
  74. LEDO JH, Azevedo EP, Beckman D, Ribeiro FC, et al
    Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-beta Oligomers in Mice.
    J Neurosci. 2016;36:12106-12116.
    PubMed     Abstract available


  75. SHI XD, Sun K, Hu R, Liu XY, et al
    Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2016;36:11959-11973.
    PubMed     Abstract available


  76. ZHANG H, Sun S, Wu L, Pchitskaya E, et al
    Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.
    J Neurosci. 2016;36:11837-11850.
    PubMed     Abstract available


    October 2016
  77. SHU S, Zhu H, Tang N, Chen W, et al
    Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1.
    J Neurosci. 2016;36:10843-10852.
    PubMed     Abstract available


    September 2016
  78. SAITO T, Matsuba Y, Yamazaki N, Hashimoto S, et al
    Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.
    J Neurosci. 2016;36:9933-6.
    PubMed     Abstract available


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