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Alzheimer's Disease

Free Subscription Articles published in J Neurosci Retrieve available abstracts of 70 articles: HTML format

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January 2026
1. MORIN TM, Cowan JL, Chen HY, Parent JH, et al
   Alzheimer's disease pathologies affect dopaminergic neural mechanisms of memory.
   J Neurosci. 2026 Jan 23:e1580252026. doi: 10.1523/JNEUROSCI.1580-25.2026.
   PubMed     Abstract available
   
   
   
2. LI X, Xie M, Ibanez CF
   Amelioration of symptomatic Alzheimer's Disease after selective impairment of p75(NTR) function in adult forebrain excitatory neurons.
   J Neurosci. 2026 Jan 21:e1939252026. doi: 10.1523/JNEUROSCI.1939-25.2026.
   PubMed     Abstract available
   
   
   
3. SLOAND TJ, Dunham BP, Niedringhaus M, West EA, et al
   Aberrant medial prefrontal cortex activity and flexible behavior in the TgF344-AD rat model of Alzheimer's disease.
   J Neurosci. 2026 Jan 13:e1387252026. doi: 10.1523/JNEUROSCI.1387-25.2026.
   PubMed     Abstract available
   
   
   November 2025
4. BHATTACHARYYA A, de la Torre-Ubieta L, Zhu Y, Head E, et al
   Development of Molecular Neuropathology in Down Syndrome across the Lifespan.
   J Neurosci. 2025;45:e1365252025.
   PubMed     Abstract available
   
   
   
5. YASSINE HN, Hugo C, O'Donovan B, Stephens IO, et al
   APOE-Targeted Therapeutics for Alzheimer's Disease.
   J Neurosci. 2025;45:e1388252025.
   PubMed     Abstract available
   
   
   October 2025
6. FU CH, Park J, Tosi U, Blanco FA, et al
   Restoration of sFRP3 preserves the neural stem cell pool and spatial discrimination ability in a mouse model of Alzheimer's disease.
   J Neurosci. 2025 Oct 24:e0049252025. doi: 10.1523/JNEUROSCI.0049-25.2025.
   PubMed     Abstract available
   
   
   
7. 
   Erratum: Barron et al., "Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease".
   J Neurosci. 2025;45:e1634252025.
   PubMed    
   
   
   September 2025
8. QU Y, Wu Y, Xu X, Cheng W, et al
   MiR-153 Prevents NRF2 Nuclear Translocation to Drive Hypoperfusion-Related Cognitive Deficits by Targeting KPNA5.
   J Neurosci. 2025;45:e2148242025.
   PubMed     Abstract available
   
   
   August 2025
9. WEISS BE, Gant JC, Lin RL, Gollihue JL, et al
   Disrupted calcium dynamics in reactive astrocytes occur with endfeet-arteriole decoupling in an amyloid mouse model of Alzheimer's disease.
   J Neurosci. 2025 Aug 15:e0349252025. doi: 10.1523/JNEUROSCI.0349-25.2025.
   PubMed     Abstract available
   
   
   June 2025
10. GERASIMOV E, Rakovskaya A, Pchitskaya E, Vlasova O, et al
    A positive allosteric modulator of the SERCA pump rescues hippocampal neuronal circuits dysfunction and cognitive defects in a mouse model of Alzheimer's disease.
    J Neurosci. 2025 Jun 24:e2337242025. doi: 10.1523/JNEUROSCI.2337-24.2025.
    PubMed     Abstract available
    
    
    
11. JIANG Y, Sachdeva K, Goulbourne CN, Berg MJ, et al
    Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration.
    J Neurosci. 2025 Jun 13:e2331242025. doi: 10.1523/JNEUROSCI.2331-24.2025.
    PubMed     Abstract available
    
    
    May 2025
12. NICODEMUS J, Liu CS, Ransom L, Tan V, et al
    Sequence diversity and encoded enzymatic differences of monocistronic L1 ORF2 mRNA variants in the aged normal and Alzheimer's disease brain.
    J Neurosci. 2025 May 14:e2298242025. doi: 10.1523/JNEUROSCI.2298-24.2025.
    PubMed     Abstract available
    
    
    April 2025
13. MORITO T, Hashimoto S, Takamura R, Watamura N, et al
    The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease.
    J Neurosci. 2025 Apr 29:e2152242025. doi: 10.1523/JNEUROSCI.2152-24.2025.
    PubMed     Abstract available
    
    
    
14. BATTOCCHIO E
    A New Molecular Mechanism for the Late-Onset Alzheimer's Disease Risk Gene CD2AP.
    J Neurosci. 2025;45:e0046252025.
    PubMed    
    
    
    March 2025
15. 
    Retraction: Larson et al., "The Complex PrP(c)-Fyn Couples Human Oligomeric Abeta with Pathological Tau Changes in Alzheimer's Disease".
    J Neurosci. 2025 Mar 6:e0301252025. doi: 10.1523/JNEUROSCI.0301-25.2025.
    PubMed    
    
    
    
16. 
    Retraction: Larson et al., "Soluble alpha-Synuclein is a Novel Modulator of Alzheimer's Disease Pathophysiology".
    J Neurosci. 2025 Mar 6:e0300252025. doi: 10.1523/JNEUROSCI.0300-25.2025.
    PubMed    
    
    
    February 2025
17. JAVED E, Suarez-Mendez I, Susi G, Roman JV, et al
    A Shift Toward Supercritical Brain Dynamics Predicts Alzheimer's Disease Progression.
    J Neurosci. 2025;45:e0688242024.
    PubMed     Abstract available
    
    
    January 2025
18. FOLEY KE, Weekman EM, Krick KE, Johnson SN, et al
    Acute Communication Between Microglia and Nonparenchymal Immune Cells in the Anti-Abeta Antibody-Injected Cortex.
    J Neurosci. 2025;45:e1456242024.
    PubMed     Abstract available
    
    
    
19. SUN X, Pan S, Li D, Su M, et al
    Cell adhesion molecule protocadherin-gammaC5 ameliorates Abeta plaque pathogenesis by modulating astrocyte function in Alzheimer's disease.
    J Neurosci. 2025 Jan 22:e0967242025. doi: 10.1523/JNEUROSCI.0967-24.2025.
    PubMed     Abstract available
    
    
    December 2024
20. 
    Erratum: Tosi et al., "The Network Structure of Cognitive Impairment: From Subjective Cognitive Decline to Alzheimer's Disease".
    J Neurosci. 2024 Dec 23:e2082242024. doi: 10.1523/JNEUROSCI.2082-24.2024.
    PubMed    
    
    
    
21. HOUCHOIS JR, Attwood JE
    The Challenges of Modulating Neuroinflammation in Alzheimer's Disease and Multiple Sclerosis with TREM2 Agonistic Antibodies.
    J Neurosci. 2024;44:e1869242024.
    PubMed    
    
    
    
22. DUNN J, Moore C, Kim NS, Gao T, et al
    Transcription Factor-Wide Association Studies (TF-WAS) to Identify Functional SNPs in Alzheimer's Disease.
    J Neurosci. 2024 Dec 2:e1800242024. doi: 10.1523/JNEUROSCI.1800-24.2024.
    PubMed     Abstract available
    
    
    November 2024
23. JANG E, Hoxha K, Mozier D, Insana A, et al
    Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread.
    J Neurosci. 2024;44:e0877242024.
    PubMed     Abstract available
    
    
    
24. SHIMOHAMA S, Fujioka R, Mihira N, Sekiguchi M, et al
    The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.
    J Neurosci. 2024;44:e0223242024.
    PubMed     Abstract available
    
    
    October 2024
25. MIRFAKHAR FS, Castanheira J, Domingues R, Ramalho JS, et al
    The Alzheimer's disease risk gene CD2AP functions in dendritic spines by remodeling F-actin.
    J Neurosci. 2024 Oct 15:e1734232024. doi: 10.1523/JNEUROSCI.1734-23.2024.
    PubMed     Abstract available
    
    
    
26. CAPOCCHI JK, Figueroa-Romero C, Dunham SJB, Faraci G, et al
    Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?
    J Neurosci. 2024;44:e1295242024.
    PubMed     Abstract available
    
    
    September 2024
27. ZHANG D, Penwell T, Chen YH, Koehler A, et al
    G-Protein Signaling in Alzheimer's Disease: Spatial Expression Validation of Semi-Supervised Deep Learning Based Computational Framework.
    J Neurosci. 2024 Sep 26:e0587242024. doi: 10.1523/JNEUROSCI.0587-24.2024.
    PubMed     Abstract available
    
    
    
28. DUGAN BJ, Dockery M
    Sex-Dependent Synaptic Alterations in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2024;44:e0961242024.
    PubMed    
    
    
    July 2024
29. LIN D, Gold A, Kaye S, Atkinson JR, et al
    Arachidonic Acid Mobilization and Peroxidation Promote Microglial Dysfunction in Abeta Pathology.
    J Neurosci. 2024;44:e0202242024.
    PubMed     Abstract available
    
    
    
30. STELZER GT, Lima-Filho RAS
    Amyloid-beta as a Key Player in Cerebrovascular Dysfunction in Alzheimer's Disease.
    J Neurosci. 2024;44:e0663242024.
    PubMed    
    
    
    June 2024
31. ETXEBERRIA A, Shen YA, Vito S, Silverman S, et al
    Neutral or detrimental effects of TREM2 agonist antibodies in preclinical models of Alzheimer's Disease and Multiple Sclerosis.
    J Neurosci. 2024 Jun 3:e2347232024. doi: 10.1523/JNEUROSCI.2347-23.2024.
    PubMed     Abstract available
    
    
    
32. TOSI G, Nigro S, Urso D, Spinosa V, et al
    The network structure of cognitive impairment: from Subjective Cognitive Decline to Alzheimer's Disease.
    J Neurosci. 2024 Jun 3:e1344232023. doi: 10.1523/JNEUROSCI.1344-23.2023.
    PubMed     Abstract available
    
    
    May 2024
33. JACOBSON KR, Song H
    Changes in the Extracellular Matrix with Aging: A Larger Role in Alzheimer's Disease.
    J Neurosci. 2024;44:e0081242024.
    PubMed    
    
    
    
34. 
    Erratum: Iba et al., "Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy".
    J Neurosci. 2024 May 28:e0865242024. doi: 10.1523/JNEUROSCI.0865-24.2024.
    PubMed    
    
    
    
35. LIU Y, Kwok W, Yoon H, Ryu JC, et al
    Imbalance in Glucose Metabolism Regulates the Transition of Microglia from Homeostasis to Disease-Associated Microglia Stage 1.
    J Neurosci. 2024;44:e1563232024.
    PubMed     Abstract available
    
    
    April 2024
36. ZHANG A, Wengler K, Zhu X, Horga G, et al
    Altered hierarchical gradients of intrinsic neural timescales in mild cognitive impairment and Alzheimer's disease.
    J Neurosci. 2024 Apr 24:e2024232024. doi: 10.1523/JNEUROSCI.2024-23.2024.
    PubMed     Abstract available
    
    
    
37. MURAKAMI R, Watanabe H, Hashimoto H, Kashiwagi-Hakozaki M, et al
    Inhibitory roles of Apolipoprotein E Christchurch astrocytes in curbing tau propagation using human pluripotent stem cell-derived models.
    J Neurosci. 2024 Apr 22:e1709232024. doi: 10.1523/JNEUROSCI.1709-23.2024.
    PubMed     Abstract available
    
    
    
38. AHMADI K, Pereira JB, Westen DV, Pasternak O, et al
    Fixel-based analysis reveals tau-related white matter changes in early stages of Alzheimer's disease.
    J Neurosci. 2024 Apr 2:e0538232024. doi: 10.1523/JNEUROSCI.0538-23.2024.
    PubMed     Abstract available
    
    
    March 2024
39. YE Q, Gast G, Wilfley EG, Huynh H, et al
    Monosynaptic rabies tracing reveals sex- and age-dependent dorsal subiculum connectivity alterations in an Alzheimer's disease mouse model.
    J Neurosci. 2024 Mar 19:e1796232024. doi: 10.1523/JNEUROSCI.1796-23.2024.
    PubMed     Abstract available
    
    
    February 2024
40. REN Q, Wang S, Li J, Cao K, et al
    Novel social stimulation ameliorates memory deficit in Alzheimer's disease model through activating alpha-secretase.
    J Neurosci. 2024 Feb 28:e1689232024. doi: 10.1523/JNEUROSCI.1689-23.2024.
    PubMed     Abstract available
    
    
    
41. ZHOU J, Wearn A, Huck J, Hughes C, et al
    Iron deposition and distribution across the hippocampus is associated with pattern separation and pattern completion in older adults at risk for Alzheimer's disease.
    J Neurosci. 2024 Feb 22:e1973232024. doi: 10.1523/JNEUROSCI.1973-23.2024.
    PubMed     Abstract available
    
    
    
42. MABOUDIAN SA, Willbrand EH, Jagust WJ, Weiner KS, et al
    Defining overlooked structures reveals new associations between cortex and cognition in aging and Alzheimer's disease.
    J Neurosci. 2024 Feb 21:e1714232024. doi: 10.1523/JNEUROSCI.1714-23.2024.
    PubMed     Abstract available
    
    
    
43. KIM CM, Diez I, Bueicheku E, Ahn S, et al
    Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging.
    J Neurosci. 2024;44:e0488232023.
    PubMed     Abstract available
    
    
    
44. PHILLIPS JS, Robinson JL, Cousins KAQ, Wolk DA, et al
    Polypathologic Associations with Gray Matter Atrophy in Neurodegenerative Disease.
    J Neurosci. 2024;44:e0808232023.
    PubMed     Abstract available
    
    
    January 2024
45. NIRAULA S, Yan SS, Subramanian J
    Amyloid Pathology Impairs Experience-Dependent Inhibitory Synaptic Plasticity.
    J Neurosci. 2024;44:e0702232023.
    PubMed     Abstract available
    
    
    
46. LOWERISON MR, Sekaran NVC, Dong Z, Chen X, et al
    Super-resolution ultrasound reveals cerebrovascular impairment in a mouse model of Alzheimer's Disease.
    J Neurosci. 2024 Jan 22:e1251232024. doi: 10.1523/JNEUROSCI.1251-23.2024.
    PubMed     Abstract available
    
    
    November 2023
47. LUKE R, Alymova I
    Unraveling the Mechanisms Underlying Disordered Sleep in Alzheimer's Disease.
    J Neurosci. 2023;43:7899-7901.
    PubMed    
    
    
    
48. BARTOSCH AMW, Youth EHH, Hansen S, Wu Y, et al
    ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease.
    J Neurosci. 2023 Nov 22:JN-RM-2324-22. doi: 10.1523/JNEUROSCI.2324-22.2023.
    PubMed     Abstract available
    
    
    
49. IWATSUBO T, Irizarry MC, Lewcock JW, Carrillo MC, et al
    Alzheimer's targeted treatments: focus on amyloid and inflammation.
    J Neurosci. 2023 Nov 14:JN-DP-1576-23. doi: 10.1523/JNEUROSCI.1576-23.2023.
    PubMed     Abstract available
    
    
    October 2023
50. ECKMAN EA, Clausen DM, Sole-Domenech S, Lee CW, et al
    Nascent Abeta42 fibrillization in synaptic endosomes precedes plaque formation in a mouse model of Alzheimer's like beta-amyloidosis.
    J Neurosci. 2023 Oct 26:JN-RM-1318-23. doi: 10.1523/JNEUROSCI.1318-23.2023.
    PubMed     Abstract available
    
    
    
51. SANO T, Ochiai T, Nagayama T, Nakamura A, et al
    Genetic Reduction of Insulin Signaling Mitigates Amyloid-beta Deposition by Promoting Expression of Extracellular Matrix Proteins in the Brain.
    J Neurosci. 2023;43:7226-7241.
    PubMed     Abstract available
    
    
    
52. ALLARD S, Hussain Shuler MG
    Cholinergic Reinforcement Signaling Is Impaired by Amyloidosis Prior to Its Synaptic Loss.
    J Neurosci. 2023;43:6988-7005.
    PubMed     Abstract available
    
    
    
53. BHEMBRE N, Bonthron C, Opazo P
    Synaptic Compensatory Plasticity in Alzheimer's Disease.
    J Neurosci. 2023;43:6833-6840.
    PubMed     Abstract available
    
    
    September 2023
54. ZHANG Z, Chan MY, Han L, Carreno CA, et al
    Dissociable effects of Alzheimer's Disease-related cognitive dysfunction and aging on functional brain network segregation.
    J Neurosci. 2023 Sep 15:JN-RM-0579-23. doi: 10.1523/JNEUROSCI.0579-23.2023.
    PubMed     Abstract available
    
    
    
55. CHEN L, Christenson Wick Z, Vetere LM, Vaughan N, et al
    Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer's disease pathology.
    J Neurosci. 2023 Sep 15:JN-RM-1204-23. doi: 10.1523/JNEUROSCI.1204-23.2023.
    PubMed     Abstract available
    
    
    
56. YIN P, Cai Y, Cui T, Berg AJ, et al
    Glial Sphingosine-mediated Epigenetic Regulation Stabilizes Synaptic Function in Drosophila Models of Alzheimer's Disease.
    J Neurosci. 2023 Sep 5:JN-RM-0515-23. doi: 10.1523/JNEUROSCI.0515-23.2023.
    PubMed     Abstract available
    
    
    August 2023
57. CASSADY KE, Chen X, Adams JN, Harrison TM, et al
    Effect of Alzheimer's pathology on task-related brain network reconfiguration in aging.
    J Neurosci. 2023 Aug 18:JN-RM-0023-23. doi: 10.1523/JNEUROSCI.0023-23.2023.
    PubMed     Abstract available
    
    
    
58. ZHOU Y, Xie L, der JS, Schuster IS, et al
    Dietary fiber and microbiota metabolite receptors enhance cognition and alleviate disease in the 5xFAD mouse model of Alzheimer's disease.
    J Neurosci. 2023 Aug 17:JN-RM-0724-23. doi: 10.1523/JNEUROSCI.0724-23.2023.
    PubMed     Abstract available
    
    
    
59. ONDREJCAK T, Klyubin I, Hu NW, O'Malley TT, et al
    Tau and Amyloid beta Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation in Vivo.
    J Neurosci. 2023;43:5870-5879.
    PubMed     Abstract available
    
    
    
60. YAO AY, Halloran PJ, Ge Y, Singh N, et al
    Bace1 deletion in the adult reverses epileptiform activity and sleep-wake disturbances in AD mice.
    J Neurosci. 2023 Aug 3:JN-RM-2124-22. doi: 10.1523/JNEUROSCI.2124-22.2023.
    PubMed     Abstract available
    
    
    July 2023
61. LENZ M, Eichler A, Kruse P, Galanis C, et al
    The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses.
    J Neurosci. 2023;43:5290-5304.
    PubMed     Abstract available
    
    
    June 2023
62. KELLY P, Sanchez-Mico MV, Hou SS, Whiteman S, et al
    Neuronally Derived Soluble Abeta Evokes Cell-Wide Astrocytic Calcium Dysregulation in Absence of Amyloid Plaques in Vivo.
    J Neurosci. 2023;43:4926-4940.
    PubMed     Abstract available
    
    
    
63. MEDINA-SAMAME A, Paller E, Bril MR, Archvadze A, et al
    Role of Neurexins in Alzheimer's Disease.
    J Neurosci. 2023;43:4194-4196.
    PubMed    
    
    
    May 2023
64. LANDRY O, Francois A, Oye Mintsa Mi-Mba MF, Traversy MT, et al
    Postsynaptic protein Shank3a deficiency synergizes with Alzheimer's disease neuropathology to impair cognitive performance in the 3xTg-AD murine model.
    J Neurosci. 2023 May 30:JN-RM-1945-22. doi: 10.1523/JNEUROSCI.1945-22.2023.
    PubMed     Abstract available
    
    
    
65. BRYANT A, Li Z, Jayakumar R, Serrano-Pozo A, et al
    Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer's Disease.
    J Neurosci. 2023 May 17:JN-RM-0237-23. doi: 10.1523/JNEUROSCI.0237-23.2023.
    PubMed     Abstract available
    
    
    
66. WALKER CK, Greathouse KM, Tuscher JJ, Dammer EB, et al
    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length.
    J Neurosci. 2023;43:3764-3785.
    PubMed     Abstract available
    
    
    April 2023
67. ZHANG K, Chen L, Li Y, Paez AG, et al
    Differential Laminar Activation Dissociates Encoding and Retrieval in the Human Medial and Lateral Entorhinal Cortex.
    J Neurosci. 2023;43:2874-2884.
    PubMed     Abstract available
    
    
    March 2023
68. SOMPOL P, Gollihue JL, Weiss BE, Lin RL, et al
    Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease.
    J Neurosci. 2023;43:1797-1813.
    PubMed     Abstract available
    
    
    
69. MA F, Akolkar H, Xu J, Liu Y, et al
    The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment.
    J Neurosci. 2023;43:1830-1844.
    PubMed     Abstract available
    
    
    February 2023
70. BHATNAGAR A, Krick K, Karisetty BC, Armour EM, et al
    Tip60's novel RNA-binding function modulates alternative splicing of pre-mRNA targets implicated in Alzheimer's Disease.
    J Neurosci. 2023 Feb 24:JN-RM-2331-22. doi: 10.1523/JNEUROSCI.2331-22.2023.
    PubMed     Abstract available
    
    

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