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Articles published in Neurobiol Aging

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Single Articles


    December 2022
  1. GUO Y, Yang YX, Zhang YR, Huang YY, et al
    Genome-wide association study of brain tau deposition as measured by (18)F-flortaucipir positron emission tomography imaging.
    Neurobiol Aging. 2022;120:128-136.
    PubMed     Abstract available


  2. PENG Z, Duggan MR, Dark HE, Daya GN, et al
    Association of liver disease with brain volume loss, cognitive decline, and plasma neurodegenerative disease biomarkers.
    Neurobiol Aging. 2022;120:34-42.
    PubMed     Abstract available


    November 2022
  3. FORREST SL, Wagner S, Kim A, Kovacs GG, et al
    Association of glial tau pathology and LATE-NC in the ageing brain.
    Neurobiol Aging. 2022;119:77-88.
    PubMed     Abstract available


  4. PHAM NTT, Graff-Radford J, Machulda MM, Spychalla AJ, et al
    Regional white matter hyperintensities in posterior cortical atrophy and logopenic progressive aphasia.
    Neurobiol Aging. 2022;119:46-55.
    PubMed     Abstract available


  5. GRIGOROVA M, Mak E, Brown SSG, Beresford-Webb J, et al
    Amyloid- beta and tau deposition influences cognitive and functional decline in Down syndrome.
    Neurobiol Aging. 2022;119:36-45.
    PubMed     Abstract available


  6. MAHON E, Lachman ME
    Voice biomarkers as indicators of cognitive changes in middle and later adulthood.
    Neurobiol Aging. 2022;119:22-35.
    PubMed     Abstract available


    October 2022
  7. WINFREE RL, Dumitrescu L, Blennow K, Zetterberg H, et al
    Biological correlates of elevated soluble TREM2 in cerebrospinal fluid.
    Neurobiol Aging. 2022;118:88-98.
    PubMed     Abstract available


  8. SETO M, Weiner RL, Dumitrescu L, Mahoney ER, et al
    RNASE6 is a novel modifier of APOE-epsilon4 effects on cognition.
    Neurobiol Aging. 2022;118:66-76.
    PubMed     Abstract available


  9. ZHUANG K, Chen X, Cassady KE, Baker SL, et al
    Metacognition, cortical thickness, and tauopathy in aging.
    Neurobiol Aging. 2022;118:44-54.
    PubMed     Abstract available


  10. CALCETAS AT, Thomas KR, Edmonds EC, Holmqvist SL, et al
    Increased regional white matter hyperintensity volume in objectively-defined subtle cognitive decline and mild cognitive impairment.
    Neurobiol Aging. 2022;118:1-8.
    PubMed     Abstract available


    September 2022
  11. WU W, Yu J, Qian X, Wang X, et al
    Intermediate-length CGG repeat expansion in NOTCH2NLC is associated with pathologically confirmed Alzheimer's disease.
    Neurobiol Aging. 2022 Sep 17. pii: S0197-4580(22)00203.
    PubMed     Abstract available


  12. SANLI BA, Whittaker KJ, Motsi GK, Shen E, et al
    Unbiased metabolome screen links serum urate to risk of Alzheimer's disease.
    Neurobiol Aging. 2022;120:167-176.
    PubMed     Abstract available


  13. COGSWELL PM, Wiste HJ, Mielke MM, Schwarz CG, et al
    CSF phosphorylated tau as an indicator of subsequent tau accumulation.
    Neurobiol Aging. 2022;117:189-200.
    PubMed     Abstract available


  14. LI H, Zhao J, Lai L, Xia Y, et al
    Loss of SST and PV positive interneurons in the ventral hippocampus results in anxiety-like behavior in 5xFAD mice.
    Neurobiol Aging. 2022;117:165-178.
    PubMed     Abstract available


  15. TAZWAR M, Evia AM, Tamhane AA, Ridwan AR, et al
    Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with lower R2 relaxation rate: an ex-vivo MRI and pathology investigation.
    Neurobiol Aging. 2022;117:128-138.
    PubMed     Abstract available


  16. NUNES PV, Suemoto CK, Rodriguez RD, Paraizo Leite RE, et al
    Neuropathology of depression in non-demented older adults: A large postmortem study of 741 individuals.
    Neurobiol Aging. 2022;117:107-116.
    PubMed     Abstract available


  17. LAO PJ, Boehme AK, Morales C, Laing KK, et al
    Amyloid, cerebrovascular disease, and neurodegeneration biomarkers are associated with cognitive trajectories in a racially and ethnically diverse, community-based sample.
    Neurobiol Aging. 2022;117:83-96.
    PubMed     Abstract available


  18. YU X, Lophatananon A, Mekli K, Burns A, et al
    A suggested shared aetiology of dementia - a colocalization study.
    Neurobiol Aging. 2022;117:71-82.
    PubMed     Abstract available


    August 2022
  19. KOTLIAR K, Ortner M, Conradi A, Hacker P, et al
    Altered retinal cerebral vessel oscillation frequencies in Alzheimer's disease compatible with impaired amyloid clearance.
    Neurobiol Aging. 2022;120:117-127.
    PubMed     Abstract available


  20. PAULSEN AJ, Schubert CR, Pinto AA, Chappell RJ, et al
    Associations of sensory and motor function with blood-based biomarkers of neurodegeneration and Alzheimer's disease in midlife.
    Neurobiol Aging. 2022;120:177-188.
    PubMed     Abstract available


  21. CHANDLER H, Wise R, Linden D, Williams J, et al
    Alzheimer's genetic risk effects on cerebral blood flow across the lifespan are proximal to gene expression.
    Neurobiol Aging. 2022;120:1-9.
    PubMed     Abstract available


  22. VIDAL-PINEIRO D, Sorensen O, Blennow K, Capogna E, et al
    Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults.
    Neurobiol Aging. 2022;116:80-91.
    PubMed     Abstract available


  23. SHEN B, Hernandez DG, Chitrala KN, Fanelli-Kuczmarski MT, et al
    APOE gene region methylation is associated with cognitive performance in middle-aged urban adults.
    Neurobiol Aging. 2022;116:41-48.
    PubMed     Abstract available


  24. MELIKYAN ZA, Corrada MM, Leiby AM, Sajjadi SA, et al
    Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study.
    Neurobiol Aging. 2022;116:12-15.
    PubMed     Abstract available


    July 2022
  25. THORP JG, Mitchell BL, Gerring ZF, Ong JS, et al
    Genetic evidence that the causal association of educational attainment with reduced risk of Alzheimer's disease is driven by intelligence.
    Neurobiol Aging. 2022 Jul 30. pii: S0197-4580(22)00164.
    PubMed     Abstract available


  26. BRACHER-SMITH M, Leonenko G, Baker E, Crawford K, et al
    Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.
    Neurobiol Aging. 2022;119:67-76.
    PubMed     Abstract available


  27. GRAFF-RADFORD J, Mielke MM, Hofrenning EI, Kouri N, et al
    Association of plasma biomarkers of amyloid and neurodegeneration with cerebrovascular disease and Alzheimer's disease.
    Neurobiol Aging. 2022;119:1-7.
    PubMed     Abstract available


  28. CORRIVEAU-LECAVALIER N, Decarie-Labbe L, Mellah S, Belleville S, et al
    Sex differences in patterns of associative memory-related activation in individuals at risk of Alzheimer's disease.
    Neurobiol Aging. 2022;119:89-101.
    PubMed     Abstract available


  29. MATHIOUDAKIS L, Dimovasili C, Bourbouli M, Latsoudis H, et al
    Study of Alzheimer's disease- and frontotemporal dementia-associated genes in the Cretan Aging Cohort.
    Neurobiol Aging. 2022 Jul 11. pii: S0197-4580(22)00146.
    PubMed     Abstract available


  30. SLEAT DE, Maita I, Banach-Petrosky W, Larrimore KE, et al
    Elevated levels of tripeptidyl peptidase 1 do not ameliorate pathogenesis in a mouse model of Alzheimer disease.
    Neurobiol Aging. 2022;118:106-107.
    PubMed     Abstract available


  31. JIANG L, Qin Y, Zhao YW, Zeng Q, et al
    PSEN1 G417S mutation in a Chinese pedigree causing early-onset parkinsonism with cognitive impairment.
    Neurobiol Aging. 2022;115:70-76.
    PubMed     Abstract available


  32. FULOPOVA B, Bennett W, Summers BS, Stuart KE, et al
    Cortical axon sub-population maintains density, but not turnover, of en passant boutons in the aged APP/PS1 amyloidosis model.
    Neurobiol Aging. 2022;115:29-38.
    PubMed     Abstract available


  33. TAN CH, Chew J, Zhang L, Gulyas B, et al
    Differential effects of white matter hyperintensities and regional amyloid deposition on regional cortical thickness.
    Neurobiol Aging. 2022;115:12-19.
    PubMed     Abstract available


  34. LAPOINT MR, Baker SL, Landau SM, Harrison TM, et al
    Rates of beta-amyloid deposition indicate widespread simultaneous accumulation throughout the brain.
    Neurobiol Aging. 2022;115:1-11.
    PubMed     Abstract available


  35. BROWN SSG, Mak E, Clare I, Grigorova M, et al
    Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down's syndrome.
    Neurobiol Aging. 2022;115:112-121.
    PubMed     Abstract available


    June 2022
  36. PALIX C, Felisatti F, Gonneaud J, Kuhn E, et al
    Relationships between diabetes-related vascular risk factors and neurodegeneration biomarkers in healthy aging and Alzheimer's disease.
    Neurobiol Aging. 2022;118:25-33.
    PubMed     Abstract available


  37. TAXIER LR, Philippi SM, Fleischer AW, York JM, et al
    APOE4 homozygote females are resistant to the beneficial effects of 17beta-estradiol on memory and CA1 dendritic spine density in the EFAD mouse model of Alzheimer's disease.
    Neurobiol Aging. 2022;118:13-24.
    PubMed     Abstract available


  38. FOOTE IF, Jacobs BM, Mathlin G, Watson CJ, et al
    The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study.
    Neurobiol Aging. 2022;117:222-235.
    PubMed     Abstract available


  39. KIM J, Jung SH, Choe YS, Kim S, et al
    Ethnic differences in the frequency of beta-amyloid deposition in cognitively normal individuals.
    Neurobiol Aging. 2022;114:27-37.
    PubMed     Abstract available


  40. PALMER JA, Kaufman CS, Vidoni ED, Honea RA, et al
    Cerebrovascular response to exercise interacts with individual genotype and amyloid-beta deposition to influence response inhibition with aging.
    Neurobiol Aging. 2022;114:15-26.
    PubMed     Abstract available


  41. KIM SJ, Woo SY, Kim YJ, Jang H, et al
    Development of prediction models for distinguishable cognitive trajectories in patients with amyloid positive mild cognitive impairment.
    Neurobiol Aging. 2022;114:84-93.
    PubMed     Abstract available


  42. HUTTULA S, Vayrynen H, Helisalmi S, Kytovuori L, et al
    NDUFA1 p.Gly32Arg variant in early-onset dementia.
    Neurobiol Aging. 2022;114:113-116.
    PubMed     Abstract available


    May 2022
  43. KHAIRE AS, Wimberly CE, Semmes EC, Hurst JH, et al
    An integrated genome and phenome-wide association study approach to understanding Alzheimer's disease predisposition.
    Neurobiol Aging. 2022 May 27. pii: S0197-4580(22)00120.
    PubMed     Abstract available


  44. MASSA F, Halbgebauer S, Barba L, Oeckl P, et al
    Exploring the brain metabolic correlates of process-specific CSF biomarkers in patients with MCI due to Alzheimer's disease: preliminary data.
    Neurobiol Aging. 2022;117:212-221.
    PubMed     Abstract available


  45. MAZZEO S, Polito C, Lassi M, Bagnoli S, et al
    Loss of speech and functional impairment in Alzheimer's disease-related primary progressive aphasia: predictive factors of decline.
    Neurobiol Aging. 2022;117:59-70.
    PubMed     Abstract available


  46. ZHOU XA, Ngiam G, Qian L, Sankorrakul K, et al
    The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer's disease mouse model.
    Neurobiol Aging. 2022;117:24-32.
    PubMed     Abstract available


  47. DONG R, Denier-Fields DN, Lu Q, Suridjan I, et al
    Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers.
    Neurobiol Aging. 2022;117:12-23.
    PubMed     Abstract available


  48. GUISLE I, Canet G, Petry S, Fereydouni-Forouzandeh P, et al
    Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia.
    Neurobiol Aging. 2022;113:118-130.
    PubMed     Abstract available


  49. MORTAMAIS M, Gutierrez LA, Balem M, Bars EL, et al
    Sulcal morphology as cognitive decline predictor in older adults with memory complaints.
    Neurobiol Aging. 2022;113:84-94.
    PubMed     Abstract available


  50. HULSHOF LA, Frajmund LA, van Nuijs D, van der Heijden DCN, et al
    Both male and female APPswe/PSEN1dE9 mice are impaired in spatial memory and cognitive flexibility at 9 months of age.
    Neurobiol Aging. 2022;113:28-38.
    PubMed     Abstract available


  51. QUINTAS-NEVES M, Teylan MA, Morais-Ribeiro R, Almeida F, et al
    Divergent magnetic resonance imaging atrophy patterns in Alzheimer's disease and primary age-related tauopathy.
    Neurobiol Aging. 2022;117:1-11.
    PubMed     Abstract available


    April 2022
  52. XIAO X, Liao X, Zhou Y, Weng L, et al
    Variants in the Niemann-pick type C genes are not associated with Alzheimer's disease: a large case-control study in the Chinese population.
    Neurobiol Aging. 2022;116:49-54.
    PubMed     Abstract available


  53. BABILONI C, Lorenzo I, Lizio R, Lopez S, et al
    Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases.
    Neurobiol Aging. 2022;115:88-108.
    PubMed     Abstract available


  54. PENG S, Roth AR, Apostolova LG, Saykin AJ, et al
    Cognitively stimulating environments and cognitive reserve: the case of personal social networks.
    Neurobiol Aging. 2022;112:197-203.
    PubMed     Abstract available


  55. MCKAY NS, Dincer A, Mehrotra V, Aschenbrenner AJ, et al
    Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults.
    Neurobiol Aging. 2022;112:181-190.
    PubMed     Abstract available


  56. TRAN TT, Speck CL, Gallagher M, Bakker A, et al
    Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment.
    Neurobiol Aging. 2022;112:151-160.
    PubMed     Abstract available


  57. ARAKAKI X, Hung SM, Rochart R, Fonteh AN, et al
    Alpha desynchronization during Stroop test unmasks cognitively healthy individuals with abnormal CSF Amyloid/Tau.
    Neurobiol Aging. 2022;112:87-101.
    PubMed     Abstract available


  58. JOHNSON AG, Webster JA, Hales CM
    Glial profiling of human tauopathy brain demonstrates enrichment of astrocytic transcripts in tau-related frontotemporal degeneration.
    Neurobiol Aging. 2022;112:55-73.
    PubMed     Abstract available


  59. KARA F, Joers JM, Deelchand DK, Park YW, et al
    (1)H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults.
    Neurobiol Aging. 2022;112:16-26.
    PubMed     Abstract available


    March 2022
  60. LI Y, Macyczko JR, Liu CC, Bu G, et al
    ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease.
    Neurobiol Aging. 2022;115:20-28.
    PubMed     Abstract available


  61. WOODFIELD A, Porter T, Gilani I, Noordin S, et al
    Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Abeta42 moderates the association between insulin resistance and increased CSF tau levels.
    Neurobiol Aging. 2022;114:38-48.
    PubMed     Abstract available


  62. SCHEIJBELER EP, Schoonhoven DN, Engels MMA, Scheltens P, et al
    Generating diagnostic profiles of cognitive decline and dementia using magnetoencephalography.
    Neurobiol Aging. 2022;111:82-94.
    PubMed     Abstract available


  63. DUGAN AJ, Nelson PT, Katsumata Y, Shade LMP, et al
    Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes.
    Neurobiol Aging. 2022;111:95-106.
    PubMed     Abstract available


    February 2022
  64. RIPHAGEN JM, Suresh MB, Salat DH
    The canonical pattern of Alzheimer's disease atrophy is linked to white matter hyperintensities in normal controls, differently in normal controls compared to in AD.
    Neurobiol Aging. 2022 Feb 28. pii: S0197-4580(22)00029.
    PubMed     Abstract available


  65. CLEMENT AN, Ribaldi F, Frisoni GB, Garibotto V, et al
    SimulAD: a dynamical model for personalized simulation and disease staging in Alzheimer's disease.
    Neurobiol Aging. 2022;113:73-83.
    PubMed     Abstract available


  66. CATANIA M, Marti A, Rossi G, Fioretti A, et al
    The novel I213S mutation in PSEN1 gene is located in a hotspot codon associated with familial early-onset Alzheimer's disease.
    Neurobiol Aging. 2022;112:191-196.
    PubMed     Abstract available


  67. MALBON AJ, Sordo L, Wilson LA, Gunn-Moore D, et al
    Alzheimer-like pathology in the parietal cortex and hippocampus of aged donkeys.
    Neurobiol Aging. 2022;113:7-14.
    PubMed     Abstract available


  68. NOVY MJ, Newbury SF, Liemisa B, Morales-Corraliza J, et al
    Expression and proteolytic processing of the amyloid precursor protein is unaffected by the expression of the three human apolipoprotein E alleles in the brains of mice.
    Neurobiol Aging. 2022;110:73-76.
    PubMed     Abstract available


    January 2022
  69. LIANG X, Liu C, Liu K, Cong L, et al
    Association and interaction of TOMM40 and PVRL2 with plasma amyloid-beta and Alzheimer's disease among Chinese older adults: a population-based study.
    Neurobiol Aging. 2022 Jan 5. pii: S0197-4580(21)00370.
    PubMed     Abstract available


  70. OLTRA-CUCARELLA J, Sanchez-SanSegundo M, Ferrer-Cascales R
    Predicting Alzheimer's disease with practice effects, APOE genotype and brain metabolism.
    Neurobiol Aging. 2022;112:111-121.
    PubMed     Abstract available


  71. INKSTER AM, Duarte-Guterman P, Albert AY, Barha CK, et al
    Are sex differences in cognitive impairment reflected in epigenetic age acceleration metrics?
    Neurobiol Aging. 2022;109:192-194.
    PubMed     Abstract available


  72. LI T, Pappas C, Le ST, Wang Q, et al
    APOE, TOMM40, and sex interactions on neural network connectivity.
    Neurobiol Aging. 2022;109:158-165.
    PubMed     Abstract available


  73. YOON B, Guo T, Provost K, Korman D, et al
    Abnormal tau in amyloid PET negative individuals.
    Neurobiol Aging. 2022;109:125-134.
    PubMed     Abstract available


    December 2021
  74. TAXIER LR, Philippi SM, York JM, LaDu MJ, et al
    The detrimental effects of APOE4 on risk for Alzheimer's disease may result from altered dendritic spine density, synaptic proteins, and estrogen receptor alpha.
    Neurobiol Aging. 2021;112:74-86.
    PubMed     Abstract available


  75. DAHL MJ, Mather M, Werkle-Bergner M, Kennedy BL, et al
    Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease.
    Neurobiol Aging. 2021;112:39-54.
    PubMed     Abstract available


  76. DADAR M, Manera AL, Ducharme S, Collins DL, et al
    White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia.
    Neurobiol Aging. 2021;111:54-63.
    PubMed     Abstract available


  77. RAMANAN S, Foxe D, El-Omar H, Ahmed RM, et al
    Evidence for a pervasive autobiographical memory impairment in Logopenic Progressive Aphasia.
    Neurobiol Aging. 2021;108:168-178.
    PubMed     Abstract available


  78. VAN DEN BOSCH KA, Verberk IMW, Ebenau JL, van der Lee SJ, et al
    BDNF-Met polymorphism and amyloid-beta in relation to cognitive decline in cognitively normal elderly: the SCIENCe project.
    Neurobiol Aging. 2021;108:146-154.
    PubMed     Abstract available


  79. FRANZ CE, Hatton SN, Elman JA, Warren T, et al
    Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age.
    Neurobiol Aging. 2021;108:80-89.
    PubMed     Abstract available


  80. SAMIMI N, Sharma G, Kimura T, Matsubara T, et al
    Distinct phosphorylation profiles of tau in brains of patients with different tauopathies.
    Neurobiol Aging. 2021;108:72-79.
    PubMed     Abstract available


  81. HU B, Geng C, Guo F, Liu Y, et al
    GABAA receptor agonist muscimol rescues inhibitory microcircuit defects in the olfactory bulb and improves olfactory function in APP/PS1 transgenic mice.
    Neurobiol Aging. 2021;108:47-57.
    PubMed     Abstract available


    November 2021
  82. PINI L, Pizzini FB, Boscolo-Galazzo I, Ferrari C, et al
    Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation.
    Neurobiol Aging. 2021;111:24-34.
    PubMed     Abstract available


  83. MECCA AP, Chen MK, O'Dell RS, Naganawa M, et al
    Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease.
    Neurobiol Aging. 2021;111:44-53.
    PubMed     Abstract available


  84. FRANCIOTTI R, Moretti DV, Benussi A, Ferri L, et al
    Cortical network modularity changes along the course of frontotemporal and Alzheimer's dementing diseases.
    Neurobiol Aging. 2021;110:37-46.
    PubMed     Abstract available


  85. EKBLAD LL, Visser PJ, Tijms BM
    Proteomic correlates of cortical thickness in cognitively normal individuals with normal and abnormal cerebrospinal fluid beta-amyloid1-42.
    Neurobiol Aging. 2021;107:42-52.
    PubMed     Abstract available


  86. SHAROAR MG, Zhou J, Benoit M, He W, et al
    Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains.
    Neurobiol Aging. 2021;107:21-29.
    PubMed     Abstract available


    October 2021
  87. JONIN PY, Duche Q, Bannier E, Corouge I, et al
    Building memories on prior knowledge: behavioral and fMRI evidence of impairment in early Alzheimer's disease.
    Neurobiol Aging. 2021;110:1-12.
    PubMed     Abstract available


  88. KO K, Yi D, Byun MS, Lee JH, et al
    Cognitive reserve proxies, Alzheimer pathologies, and cognition.
    Neurobiol Aging. 2021;110:88-95.
    PubMed     Abstract available


  89. ZHANG H, Wang H, Gao F, Yang J, et al
    TSPO deficiency accelerates amyloid pathology and neuroinflammation by impairing microglial phagocytosis.
    Neurobiol Aging. 2021;106:292-303.
    PubMed     Abstract available


  90. KOINUMA S, Shimozawa N, Yasutomi Y, Kimura N, et al
    Aging induces abnormal accumulation of Abeta in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain.
    Neurobiol Aging. 2021;106:268-281.
    PubMed     Abstract available


  91. VAN DER THIEL MM, Freeze WM, Verheggen ICM, Wong SM, et al
    Associations of increased interstitial fluid with vascular and neurodegenerative abnormalities in a memory clinic sample.
    Neurobiol Aging. 2021;106:257-267.
    PubMed     Abstract available


  92. LEE YG, Park M, Jeong SH, Kang SW, et al
    Effects of baseline serum uric acid and apolipoprotein E4 on longitudinal cognition and cerebral metabolism.
    Neurobiol Aging. 2021;106:223-231.
    PubMed     Abstract available


  93. CULLELL N, Carcel-Marquez J, Gallego-Fabrega C, Muino E, et al
    Sleep/wake cycle alterations as a cause of neurodegenerative diseases: A Mendelian randomization study.
    Neurobiol Aging. 2021;106:320.
    PubMed     Abstract available


  94. LORD J, Zettergren A, Ashton NJ, Karikari TK, et al
    A genome-wide association study of plasma phosphorylated tau181.
    Neurobiol Aging. 2021;106:304.
    PubMed     Abstract available


    September 2021
  95. HONE-BLANCHET A, Bohsali A, Krishnamurthy LC, Shahid S, et al
    Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
    Neurobiol Aging. 2021;109:22-30.
    PubMed     Abstract available


  96. KULMINSKI AM, Philipp I, Shu L, Culminskaya I, et al
    Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk.
    Neurobiol Aging. 2021 Sep 15. pii: S0197-4580(21)00290.
    PubMed     Abstract available


  97. KOENIG LN, LaMontagne P, Glasser MF, Bateman R, et al
    Regional age-related atrophy after screening for preclinical alzheimer disease.
    Neurobiol Aging. 2021;109:43-51.
    PubMed     Abstract available


  98. CHARISSE D, Erus G, Pomponio R, Gorges M, et al
    Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease.
    Neurobiol Aging. 2021;109:31-42.
    PubMed     Abstract available


  99. BONOMI CG, De Lucia V, Mascolo AP, Assogna M, et al
    Brain energy metabolism and neurodegeneration: hints from CSF lactate levels in dementias.
    Neurobiol Aging. 2021;105:333-339.
    PubMed     Abstract available


  100. OLAJIDE OJ, Chapman CA
    Amyloid-beta (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex.
    Neurobiol Aging. 2021;105:296-309.
    PubMed     Abstract available


  101. ENNIS GE, Kohli A, Jonaitis EM, Betthauser TJ, et al
    The relationship of glucose-stimulated insulin secretion to cerebral glucose metabolism and cognition in healthy middle-aged and older adults.
    Neurobiol Aging. 2021;105:174-185.
    PubMed     Abstract available


  102. QUINTANA DD, Anantula Y, Garcia JA, Engler-Chiurazzi EB, et al
    Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice.
    Neurobiol Aging. 2021;105:115-128.
    PubMed     Abstract available


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    Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics.
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    Obesity is associated with reduced cerebral blood flow - modified by physical activity.
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    August 2021
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    Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease.
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  107. ZHANG Z, Wang M, Liu X
    C-reactive protein and risk of Alzheimer's disease.
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  108. PALIWAL D, McInerney TW, Pa J, Swerdlow RH, et al
    Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease.
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  109. SHEPHERD A, Lim JKH, Wong VHY, Zeleznikow-Johnston AM, et al
    Progressive impairments in executive function in the APP/PS1 model of Alzheimer's disease as measured by translatable touchscreen testing.
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  110. WILLEMSE EAJ, Sieben A, Somers C, Vermeiren Y, et al
    Neurogranin as biomarker in CSF is non-specific to Alzheimer's disease dementia.
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  111. BELFIORE ACR, Oddo S
    Retraction notice to "Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease" [Neurobiology of Aging Volume 68, August 2018, Page 59-67].
    Neurobiol Aging. 2021;104:139.
    PubMed    


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    Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.
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    July 2021
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    Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome.
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  114. TATARYN NM, Singh V, Dyke JP, Berk-Rauch HE, et al
    Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease.
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  115. IONESCU-TUCKER A, Cotman CW
    Emerging roles of oxidative stress in brain aging and Alzheimer's disease.
    Neurobiol Aging. 2021;107:86-95.
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  116. LIM B, Grontvedt GR, Bathala P, Kale SS, et al
    CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia.
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    Absence of coding somatic single nucleotide variants within well-known candidate genes in late-onset sporadic Alzheimer's Disease based on the analysis of multi-omics data.
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  118. LEMERCIER P, Vergallo A, Lista S, Zetterberg H, et al
    Association of plasma Abeta40/Abeta42 ratio and brain Abeta accumulation: testing a whole-brain PLS-VIP approach in individuals at risk of Alzheimer's disease.
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  119. NAUDE PJW, Ramakers IHGB, van der Flier WM, Jiskoot LC, et al
    Serum and cerebrospinal fluid Neutrophil gelatinase-associated lipocalin (NGAL) levels as biomarkers for the conversion from mild cognitive impairment to Alzheimer's disease dementia.
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  120. VAN DER LINDEN RJ, Reus LM, De Witte W, Tijms BM, et al
    Genetic overlap between Alzheimer's disease and blood lipid levels.
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  121. CEYZERIAT K, Zilli T, Fall AB, Millet P, et al
    Treatment by low-dose brain radiation therapy improves memory performances without changes of the amyloid load in the TgF344-AD rat model.
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  122. XU W, Tan CC, Cao XP, Tan L, et al
    Neuroinflammation modulates the association of PGRN with cerebral amyloid-beta burden.
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    June 2021
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    Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons.
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    Higher motor cortical excitability linked to greater cognitive dysfunction in Alzheimer's disease: results from two independent cohorts.
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  127. SANGHA O, Ma D, Popuri K, Stocks J, et al
    Structural volume and cortical thickness differences between males and females in cognitively normal, cognitively impaired and Alzheimer's dementia population.
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  128. BANKS SJ, Andrews MJ, Digma L, Madsen J, et al
    Sex differences in Alzheimer's disease: do differences in tau explain the verbal memory gap?
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  129. BUTT OH, Long JM, Henson RL, Herries E, et al
    Cognitively normal APOE epsilon4 carriers have specific elevation of CSF SNAP-25.
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    May 2021
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    The role of frontotemporal dementia associated genes in patients with Alzheimer's disease.
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  131. TUBI MA, Kothapalli D, Hapenney M, Feingold FW, et al
    Regional relationships between CSF VEGF levels and Alzheimer's disease brain biomarkers and cognition.
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    A machine learning approach to screen for preclinical Alzheimer's disease.
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  133. BOSSAERTS L, Hens E, Hanseeuw B, Vandenberghe R, et al
    Premature termination codon mutations in ABCA7 contribute to Alzheimer's disease risk in Belgian patients.
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    Disappearing metabolic youthfulness in the cognitively impaired female brain.
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  135. KRONENBERG G, Gertz K, Schoner J, Bertram L, et al
    BDNF serum concentrations in 2053 participants of the Berlin Aging Study II.
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  136. BELLOY ME, Eger SJ, Le Guen Y, Napolioni V, et al
    KL *VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE *4 carriers.
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  137. ZUO Z, Qi F, Xing Z, Yuan L, et al
    Bacille Calmette-Guerin attenuates vascular amyloid pathology and maximizes synaptic preservation in APP/PS1 mice following active amyloid-beta immunotherapy.
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  138. SMITH GS, Kuwabara H, Nandi A, Gould NF, et al
    Molecular imaging of beta-amyloid deposition in late-life depression.
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    Mutations in the COPI coatomer subunit alpha-COP induce release of Abeta-42 and amyloid precursor protein intracellular domain and increase tau oligomerization and release.
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    April 2021
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    Amyloid toxicity in a Drosophila Alzheimer's model is ameliorated by autophagy activation.
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  141. EDWARDS L, La Joie R, Iaccarino L, Strom A, et al
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    Generalization of memory-related brain function in asymptomatic older women with a family history of late onset Alzheimer's Disease: Results from the PREVENT-AD Cohort.
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    Associations between brain amyloid accumulation and the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers.
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    March 2021
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    Investigation of the role of matrix metalloproteinases in the genetic etiology of Alzheimer's disease.
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    Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro.
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  147. HU K, Li P, Gao L
    Sleep, rest-activity rhythms and aging: a complex web in Alzheimer's disease?
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    Heterogenous deposition of beta-amyloid in the brain of aged dogs.
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    February 2021
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    Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease.
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  150. CACCIOTTOLO M, Morgan TE, Finch CE
    Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice.
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  151. RAJABLI F, Feliciano-Astacio BE, Cukier HN, Wang L, et al
    Linkage of Alzheimer disease families with Puerto Rican ancestry identifies a chromosome 9 locus.
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  152. BETTCHER BM, Olson KE, Carlson NE, McConnell BV, et al
    Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease.
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  153. KARA F, Belloy ME, Voncken R, Sarwari Z, et al
    Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease.
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    Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum.
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    Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach.
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    A novel presenilin 1 duplication mutation (Ile168dup) causing Alzheimer's disease associated with myoclonus, seizures and pyramidal features.
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    Neurodegeneration, Alzheimer's disease biomarkers, and longitudinal verbal learning and memory performance in late middle age.
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    Different patterns of beta-amyloid deposition in patients with Alzheimer's disease according to the presence of mild parkinsonism.
    Neurobiol Aging. 2021;101:199-206.
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  160. KIM BH, Nho K, Lee JM
    Genome-wide association study identifies susceptibility loci of brain atrophy to NFIA and ST18 in Alzheimer's disease.
    Neurobiol Aging. 2021 Feb 3. pii: S0197-4580(21)00028.
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    Cross-sectional and longitudinal medial temporal lobe subregional atrophy patterns in semantic variant primary progressive aphasia.
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    SQSTM1/ p62 oligomerization contributes to Abeta-induced inhibition of Nrf2 signaling.
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    Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats.
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    Anterolateral entorhinal cortex volume is associated with memory retention in clinically unimpaired older adults.
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    Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.
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  166. MEEKER KL, Ances BM, Gordon BA, Rudolph CW, et al
    Cerebrospinal fluid Abeta42 moderates the relationship between brain functional network dynamics and cognitive intraindividual variability.
    Neurobiol Aging. 2021;98:116-123.
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    January 2021
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    Differential associations of age and Alzheimer's disease with sleep and rest-activity rhythms across the adult lifespan.
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    Functional connectivity differences in Alzheimer's disease and amnestic mild cognitive impairment associated with AT(N) classification and anosognosia.
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    Presenilin 1 mutation likely contributes to U1 small nuclear RNA dysregulation and Alzheimer's disease-like symptoms.
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    Decreased pH in the aging brain and Alzheimer's disease.
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    Metabolic syndrome and its components in relation to in vivo brain amyloid and neurodegeneration in late middle age.
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    December 2020
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    The value of multimodal imaging with (123)I-FP-CIT SPECT in differential diagnosis of dementia with Lewy bodies and Alzheimer's disease dementia.
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    Dissecting the role of Amerindian genetic ancestry and the ApoE epsilon4 allele on Alzheimer disease in an admixed Peruvian population.
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  175. WENG FL, He L
    Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer's disease.
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    November 2020
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    Suppression of the kinase for elongation factor 2 alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease.
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    Genetic variants in glutamate-, Abeta-, and tau-related pathways determine polygenic risk for Alzheimer's disease.
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    Causal relationships between gut metabolites and Alzheimer's disease: a bidirectional Mendelian randomization study.
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    Associations between Alzheimer's disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participants.
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    Association of the CD2AP locus with cognitive functioning among middle-aged individuals with a family history of Alzheimer's disease.
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    October 2020
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    Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease.
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    Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology.
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    Alzheimer amyloid-beta- peptide disrupts membrane localization of glucose transporter 1 in astrocytes: implications for glucose levels in brain and blood.
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    Herpes simplex virus and Alzheimer's disease: a Mendelian randomization study.
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    Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer's disease.
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    September 2020
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    The age-dependent associations of white matter hyperintensities and neurofilament light in early- and late-stage Alzheimer's disease.
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    August 2020
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    Evaluating resting-state BOLD variability in relation to biomarkers of preclinical Alzheimer's disease.
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    July 2020
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