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Articles published in J Biol Chem

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    September 2021
  1. NIES SH, Takahashi H, Herber CS, Huttner A, et al
    Spreading of Alzheimer Tau seeds is enhanced by aging and template matching with limited impact of amyloid-beta.
    J Biol Chem. 2021 Sep 1:101159. doi: 10.1016/j.jbc.2021.101159.
    PubMed     Abstract available

    August 2021
  2. PERDIGAO C, Barata MA, Burrinha T, Almeida CG, et al
    Alzheimer's disease BIN1 coding variants increase intracellular Abeta levels by interfering with BACE1 recycling.
    J Biol Chem. 2021 Aug 7:101056. doi: 10.1016/j.jbc.2021.101056.
    PubMed     Abstract available

    July 2021
  3. SATO K, Watamura N, Fujioka R, Mihira N, et al
    A 3(rd) generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid beta peptide.
    J Biol Chem. 2021 Jul 27:101004. doi: 10.1016/j.jbc.2021.101004.
    PubMed     Abstract available

  4. VALVERDE A, Dunys J, Lorivel T, Debayle D, et al
    Dipeptidyl peptidase 4 contributes to Alzheimer's disease-like defects in a mouse model and is increased in sporadic Alzheimer's disease brains.
    J Biol Chem. 2021 Jul 12:100963. doi: 10.1016/j.jbc.2021.100963.
    PubMed     Abstract available

  5. KAYED R
    Infectious Etiology and Amyloidosis in Alzheimer's Disease: The Puzzle Continues.
    J Biol Chem. 2021 Jul 1:100936. doi: 10.1016/j.jbc.2021.100936.
    PubMed     Abstract available

    May 2021
  6. BOCHAROVA O, Pandit NP, Molesworth K, Fisher A, et al
    Alzheimer's disease-associated beta-Amyloid does not protect against Herpes Simplex Virus 1 infection in the mouse brain.
    J Biol Chem. 2021 May 27:100845. doi: 10.1016/j.jbc.2021.100845.
    PubMed     Abstract available

    April 2021
  7. VILALTA A, Zhou Y, Sevalle J, Griffin JK, et al
    Wild-type sTREM2 blocks Abeta aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Abeta aggregation.
    J Biol Chem. 2021 Apr 3:100631. doi: 10.1016/j.jbc.2021.100631.
    PubMed     Abstract available

    February 2021
  8. LIU L, Lauro BM, Wolfe MS, Selkoe DJ, et al
    Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate gamma-secretase function in generating Alzheimer-causing Abeta peptides.
    J Biol Chem. 2021 Feb 8:100393. doi: 10.1016/j.jbc.2021.100393.
    PubMed     Abstract available

    January 2021
  9. SOLOVYEV N, El-Khatib AH, Costas-Rodriguez M, Schwab K, et al
    Cu, Fe and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.
    J Biol Chem. 2021 Jan 13:100292. doi: 10.1016/j.jbc.2021.100292.
    PubMed     Abstract available

  10. DEVKOTA S, Williams TD, Wolfe MS
    Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by gamma-secretase to increase amyloid beta-peptides of >45 residues.
    J Biol Chem. 2021 Jan 12:100281. doi: 10.1016/j.jbc.2021.100281.
    PubMed     Abstract available

  11. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2021 Jan 8:100241. doi: 10.1074/jbc.RA120.015327.
    PubMed     Abstract available

  12. CHECLER F, Afram E, Pardossi-Piquard R, Lauritzen I, et al
    Is gamma-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
    J Biol Chem. 2021;296:100489.
    PubMed     Abstract available

  13. SHIELDS LY, Li H, Nguyen K, Kim H, et al
    Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity.
    J Biol Chem. 2021;296:100469.
    PubMed     Abstract available

  14. LEE YH, Im E, Hyun M, Park J, et al
    Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation.
    J Biol Chem. 2021;296:100245.
    PubMed     Abstract available

  15. TALESKI G, Schuhmacher D, Su H, Sontag JM, et al
    Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.
    J Biol Chem. 2021;296:100237.
    PubMed     Abstract available

  16. REYES-RUIZ JM, Nakajima R, Baghallab I, Goldschmidt L, et al
    An "epitomic" analysis of the specificity of conformation-dependent, anti-Ass amyloid monoclonal antibodies.
    J Biol Chem. 2021;296:100168.
    PubMed     Abstract available

  17. ABREHA MH, Ojelade S, Dammer EB, McEachin ZT, et al
    TBK1 interacts with tau and enhances neurodegeneration in tauopathy.
    J Biol Chem. 2021;296:100760.
    PubMed     Abstract available

  18. KONIG AS, Rosener NS, Gremer L, Tusche M, et al
    Structural details of amyloid beta oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy.
    J Biol Chem. 2021;296:100499.
    PubMed     Abstract available

  19. ROBERTS JP, Stokoe SA, Sathler MF, Nichols RA, et al
    Selective coactivation of alpha7- and alpha4beta2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction.
    J Biol Chem. 2021;296:100402.
    PubMed     Abstract available

    December 2020
  20. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2020 Dec 29. pii: RA120.015327. doi: 10.1074/jbc.RA120.015327.
    PubMed     Abstract available

  21. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020;295:17138-17147.
    PubMed     Abstract available

    November 2020
  22. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020;296:100089.
    PubMed     Abstract available

  23. LEI P, Ayton S, Bush AI
    The Essential Elements of Alzheimer's Disease.
    J Biol Chem. 2020 Nov 20. pii: REV120.008207. doi: 10.1074/jbc.REV120.008207.
    PubMed     Abstract available

  24. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020 Nov 16. pii: RA120.016395. doi: 10.1074/jbc.RA120.016395.
    PubMed     Abstract available

    October 2020
  25. MAULIK M, Vasan L, Bose A, Dutta Chowdhury S, et al
    Amyloid-beta regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes.
    J Biol Chem. 2020;295:15097-15111.
    PubMed     Abstract available

  26. CAO Q, Anderson DH, Liang WY, Chou J, et al
    The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.
    J Biol Chem. 2020;295:14015-14024.
    PubMed     Abstract available

  27. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule Affinity Regulating Kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020 Oct 5. pii: RA120.014420. doi: 10.1074/jbc.RA120.014420.
    PubMed     Abstract available

  28. GU J, Xu W, Jin N, Li L, et al
    Truncation of Tau selectively facilitates its pathological activities.
    J Biol Chem. 2020;295:13812-13828.
    PubMed     Abstract available

    September 2020
  29. MORI T, Koyama N, Yokoo T, Segawa T, et al
    Gallic Acid is a Dual alpha/beta-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
    J Biol Chem. 2020 Sep 10. pii: RA119.012330. doi: 10.1074/jbc.RA119.012330.
    PubMed     Abstract available

  30. KAESER G, Chun J
    Brain cell somatic gene recombination and its phylogenetic foundations.
    J Biol Chem. 2020;295:12786-12795.
    PubMed     Abstract available

    August 2020
  31. SHIMONAKA S, Matsumoto SE, Elahi M, Ishiguro K, et al
    Asparagine residue 368 is involved in Alzheimer's disease tau strain-specific aggregation.
    J Biol Chem. 2020 Aug 5. pii: RA120.013271. doi: 10.1074/jbc.RA120.013271.
    PubMed     Abstract available

    July 2020
  32. KATSIKOUDI A, Ficulle E, Cavallini A, Sharman G, et al
    Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures.
    J Biol Chem. 2020 Jul 22. pii: RA120.013325. doi: 10.1074/jbc.RA120.013325.
    PubMed     Abstract available

  33. GOTOH N, Saito Y, Hata S, Saito H, et al
    Amyloidogenic processing of amyloid beta protein precursor (APP) is enhanced in the brains of alcadein alpha-deficient mice.
    J Biol Chem. 2020;295:9650-9662.
    PubMed     Abstract available

  34. NACHMAN E, Wentink AS, Madiona K, Bousset L, et al
    Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
    J Biol Chem. 2020;295:9676-9690.
    PubMed     Abstract available

  35. CROOKS EJ, Irizarry BA, Ziliox M, Kawakami T, et al
    Copper stabilizes antiparallel beta-sheet fibrils of the amyloid beta40 (Abeta40)-Iowa variant.
    J Biol Chem. 2020;295:8914-8927.
    PubMed     Abstract available

    June 2020
  36. ABSKHARON R, Seidler PM, Sawaya MR, Cascio D, et al
    Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
    J Biol Chem. 2020 Jun 3. pii: RA120.013638. doi: 10.1074/jbc.RA120.013638.
    PubMed     Abstract available

    May 2020
  37. WALLIN C, Jarvet J, Biverstal H, Warmlander S, et al
    Metal ion coordination delays amyloid-beta peptide self-assembly by forming an aggregation-inert complex.
    J Biol Chem. 2020;295:7224-7234.
    PubMed     Abstract available

  38. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42 and high Abeta43.
    J Biol Chem. 2020;295:7442-7451.
    PubMed     Abstract available

  39. SINGH V, Xu L, Boyko S, Surewicz K, et al
    Zinc promotes liquid-liquid phase separation of tau protein.
    J Biol Chem. 2020;295:5850-5856.
    PubMed     Abstract available

    April 2020
  40. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42, high Abeta43.
    J Biol Chem. 2020 Apr 7. pii: RA120.012542. doi: 10.1074/jbc.RA120.012542.
    PubMed     Abstract available

    March 2020
  41. CROWE A, Henderson MJ, Anderson J, Titus SA, et al
    Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
    J Biol Chem. 2020;295:4001-4013.
    PubMed     Abstract available

  42. MURAKAMI K, Obata Y, Sekikawa A, Ueda H, et al
    An RNA aptamer with potent affinity for a toxic dimer of amyloid beta42 has potential utility for histochemical studies of Alzheimer's disease.
    J Biol Chem. 2020 Mar 2. pii: RA119.010955. doi: 10.1074/jbc.RA119.010955.
    PubMed     Abstract available

    January 2020
  43. XIAO Y, Matsuda I, Inoue M, Sasahara T, et al
    NMR-based site-resolved profiling of beta-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.
    J Biol Chem. 2020;295:458-467.
    PubMed     Abstract available

    September 2019
  44. SEIDLER PM, Boyer DR, Murray KA, Yang TP, et al
    Structure-based inhibitors halt prion-like seeding by Alzheimer's disease- and tauopathy-derived brain tissue samples.
    J Biol Chem. 2019 Sep 19. pii: RA119.009688. doi: 10.1074/jbc.RA119.009688.
    PubMed     Abstract available

  45. SCHWEIG JE, Yao H, Coppola K, Jin C, et al
    Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivo.
    J Biol Chem. 2019;294:13378-13395.
    PubMed     Abstract available

    August 2019
  46. TAM SW, Feng R, Lau WK, Law AC, et al
    Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation.
    J Biol Chem. 2019;294:12495-12506.
    PubMed     Abstract available

    July 2019
  47. SHARMA G, Huo A, Kimura T, Shiozawa S, et al
    Tau isoform expression and phosphorylation in marmoset brains.
    J Biol Chem. 2019;294:11433-11444.
    PubMed     Abstract available

  48. LESSARD CB, Rodriguez E, Ladd TB, Minter LM, et al
    Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
    J Biol Chem. 2019;294:11276-11285.
    PubMed     Abstract available

  49. FURUSAWA K, Takasugi T, Chiu YW, Hori Y, et al
    CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.
    J Biol Chem. 2019;294:10886-10899.
    PubMed     Abstract available

    June 2019
  50. LIPPENS G, Gigant B
    Elucidating Tau function and dysfunction in the era of cryo-EM.
    J Biol Chem. 2019;294:9316-9325.
    PubMed     Abstract available

    May 2019
  51. NG J, Kaur H, Collier T, Chang K, et al
    Site-specific glycation of Abeta1-42 affects fibril formation and is neurotoxic.
    J Biol Chem. 2019;294:8806-8818.
    PubMed     Abstract available

  52. BODE DC, Freeley M, Nield J, Palma M, et al
    Amyloid-beta oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy.
    J Biol Chem. 2019;294:7566-7572.
    PubMed     Abstract available

  53. LIU S, Ando F, Fujita Y, Liu J, et al
    A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice.
    J Biol Chem. 2019 May 9. pii: RA118.006420. doi: 10.1074/jbc.RA118.006420.
    PubMed     Abstract available

    April 2019
  54. JAROSZ-GRIFFITHS HH, Corbett NJ, Rowland HA, Fisher K, et al
    Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-beta oligomers.
    J Biol Chem. 2019;294:7085-7097.
    PubMed     Abstract available

    February 2019
  55. MICHNO W, Nystrom S, Wehrli P, Lashley T, et al
    Pyroglutamation of amyloid-betax-42 (Abetax-42) followed by Abeta1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology.
    J Biol Chem. 2019 Feb 27. pii: RA118.006604. doi: 10.1074/jbc.RA118.006604.
    PubMed     Abstract available

  56. SMITH LM, Kostylev MA, Lee S, Strittmatter SM, et al
    Systematic and standardized comparison of reported Amyloid-beta receptors for sufficiency, affinity, and Alzheimer's disease relevance.
    J Biol Chem. 2019 Feb 20. pii: RA118.006252. doi: 10.1074/jbc.RA118.006252.
    PubMed     Abstract available

  57. JEAN L, Brimijoin S, Vaux DJ
    In vivo localization of human acetylcholinesterase-derived species in a beta-sheet conformation at the core of senile plaques in Alzheimer's disease.
    J Biol Chem. 2019 Feb 20. pii: RA118.006230. doi: 10.1074/jbc.RA118.006230.
    PubMed     Abstract available

  58. TANG TC, Kienlen-Campard P, Hu Y, Perrin F, et al
    Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and gamma-secretase processing of the C99 peptide.
    J Biol Chem. 2019 Feb 12. pii: RA118.006061. doi: 10.1074/jbc.RA118.006061.
    PubMed     Abstract available

    January 2019
  59. ANDREW RJ, De Rossi P, Nguyen P, Kowalski HR, et al
    Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model.
    J Biol Chem. 2019 Jan 28. pii: RA118.006379. doi: 10.1074/jbc.RA118.006379.
    PubMed     Abstract available

  60. HUR WS, Mazinani N, Lu XJD, Yefet LS, et al
    Coagulation factor XIIIa cross-links amyloid beta into dimers and oligomers and to blood proteins.
    J Biol Chem. 2019;294:390-396.
    PubMed     Abstract available

    December 2018
  61. MORI T, Koyama N, Tan J, Segawa T, et al
    Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice.
    J Biol Chem. 2018 Dec 18. pii: RA118.004280. doi: 10.1074/jbc.RA118.004280.
    PubMed     Abstract available

    November 2018
  62. WEISMILLER HA, Murphy R, Wei G, Ma B, et al
    Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms.
    J Biol Chem. 2018;293:17336-17348.
    PubMed     Abstract available

    October 2018
  63. SADLEIR KR, Popovic J, Vassar R
    ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.
    J Biol Chem. 2018 Oct 12. pii: RA118.005769. doi: 10.1074/jbc.RA118.005769.
    PubMed     Abstract available

    August 2018
  64. DUNYS J, Valverde A, Checler F
    Are N- and C-terminally Truncated Abeta species key pathological triggers in Alzheimer's disease?
    J Biol Chem. 2018 Aug 24. pii: R118.003999. doi: 10.1074/jbc.R118.003999.
    PubMed     Abstract available

  65. EMENDATO A, Milordini G, Zacco E, Sicorello A, et al
    Glycation affects fibril formation of Abeta peptides.
    J Biol Chem. 2018;293:13100-13111.
    PubMed     Abstract available

  66. DODD RB
    An exTREMe disruption in Alzheimer's cleanup.
    J Biol Chem. 2018;293:12647-12648.
    PubMed     Abstract available

    July 2018
  67. SANKAR SB, Donegan RK, Shah KJ, Reddi AR, et al
    Heme and hemoglobin suppress amyloid beta-mediated inflammatory activation of mouse astrocytes.
    J Biol Chem. 2018;293:11358-11373.
    PubMed     Abstract available

  68. GRIGNASCHI E, Cereghetti G, Grigolato F, Kopp MRG, et al
    A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro.
    J Biol Chem. 2018;293:11424-11432.
    PubMed     Abstract available

    June 2018
  69. YOUNAN ND, Chen KF, Rose RS, Crowther DC, et al
    Prion protein stabilizes amyloid-beta (Abeta) oligomers and enhances Abeta neurotoxicity in a Drosophila model of Alzheimer disease.
    J Biol Chem. 2018 Jun 10. pii: RA118.003319. doi: 10.1074/jbc.RA118.003319.
    PubMed     Abstract available

    May 2018
  70. BISHOF I, Dammer EB, Duong DM, Kundinger S, et al
    RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.
    J Biol Chem. 2018 May 25. pii: RA118.001747. doi: 10.1074/jbc.RA118.001747.
    PubMed     Abstract available

  71. SUDOM A, Talreja S, Danao J, Bragg E, et al
    Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
    J Biol Chem. 2018 May 24. pii: RA118.002352. doi: 10.1074/jbc.RA118.002352.
    PubMed     Abstract available

  72. TAYLOR IR, Ahmad A, Wu T, Nordhues BA, et al
    The disorderly conduct of Hsc70 and its interaction with the Alzheimer's related Tau protein.
    J Biol Chem. 2018 May 15. pii: RA118.002234. doi: 10.1074/jbc.RA118.002234.
    PubMed     Abstract available

  73. BAK LK, Walls AB, Schousboe A, Waagepetersen HS, et al
    Astrocytic glycogen metabolism in the healthy and diseased brain.
    J Biol Chem. 2018;293:7108-7116.
    PubMed     Abstract available

    April 2018
  74. MONDRAGON RODRIGUEZ S, Salas Gallardo A, Gonzalez Pereyra P, Macias M, et al
    Phosphorylation of tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model.
    J Biol Chem. 2018 Apr 9. pii: RA117.001187. doi: 10.1074/jbc.RA117.001187.
    PubMed     Abstract available

    March 2018
  75. CHENG Q, Danao J, Talreja S, Wen P, et al
    TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant TREM2(R47H) on murine myeloid cell function.
    J Biol Chem. 2018 Mar 29. pii: RA118.001848. doi: 10.1074/jbc.RA118.001848.
    PubMed     Abstract available

    January 2018
  76. HASHIMOTO S, Ishii A, Kamano N, Watamura N, et al
    Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm.
    J Biol Chem. 2018 Jan 3. pii: M117.811315. doi: 10.1074/jbc.M117.811315.
    PubMed     Abstract available

    December 2017
  77. GODOY MA, Saraiva LM, Carvalho LRP, Vasconcelos-Dos-Santos A, et al
    Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-beta oligomers.
    J Biol Chem. 2017 Dec 28. pii: M117.807180. doi: 10.1074/jbc.M117.807180.
    PubMed     Abstract available

  78. LAHIRI DK, Maloney B, Greig NH
    Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders.
    J Biol Chem. 2017;292:20353.

    October 2017
  79. BOVE-FENDERSON E, Urano R, Straub JE, Harris DA, et al
    Cellular prion protein targets amyloid-beta fibril ends via its C-terminal domain to prevent elongation.
    J Biol Chem. 2017;292:16858-16871.
    PubMed     Abstract available

  80. SAADIPOUR K, MacLean M, Pirkle S, Ali S, et al
    The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor.
    J Biol Chem. 2017;292:16594-16604.
    PubMed     Abstract available

    September 2017
  81. CARLOMAGNO Y, Chung DC, Yue M, Castanedes-Casey M, et al
    An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.
    J Biol Chem. 2017;292:15277-15286.
    PubMed     Abstract available

    August 2017
  82. SHMUEL-GALIA L, Klug Y, Porat Z, Charni M, et al
    Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.
    J Biol Chem. 2017;292:13415-13427.
    PubMed     Abstract available

    July 2017
  83. SIDDIQUI SS, Springer SA, Verhagen A, Sundaramurthy V, et al
    The Alzheimer's Disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.
    J Biol Chem. 2017 Jul 26. pii: jbc.M117.799346. doi: 10.1074/jbc.M117.799346.
    PubMed     Abstract available

  84. ZEMPEL H, Dennissen FJA, Kumar Y, Luedtke J, et al
    Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture.
    J Biol Chem. 2017;292:12192-12207.
    PubMed     Abstract available

    June 2017
  85. VARNUM MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, et al
    A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
    J Biol Chem. 2017;292:10651-10663.
    PubMed     Abstract available

  86. PIECHOTTA A, Parthier C, Kleinschmidt M, Gnoth K, et al
    Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
    J Biol Chem. 2017 Jun 16. pii: jbc.M117.777839. doi: 10.1074/jbc.M117.777839.
    PubMed     Abstract available

  87. BUSSIERE R, Lacampagne A, Reiken S, Liu X, et al
    Amyloid beta production is regulated by beta2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.
    J Biol Chem. 2017;292:10153-10168.
    PubMed     Abstract available

    May 2017
  88. HU ZW, Ma MR, Chen YX, Zhao YF, et al
    Phosphorylation at Ser8 as an intrinsic regulatory switch to regulate the morphologies and structures of Alzheimer's 40-residue beta-amyloid (Abeta40) fibrils.
    J Biol Chem. 2017;292:8846.

  89. YOSHIMURA Y, Holmberg MA, Kukic P, Andersen CB, et al
    MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions.
    J Biol Chem. 2017;292:8269-8278.
    PubMed     Abstract available

  90. MORI T, Koyama N, Tan J, Segawa T, et al
    Combination Therapy with Octyl Gallate and Ferulic Acid Improves Cognition and Neurodegeneration in a Transgenic Mouse Model of Alzheimer Disease.
    J Biol Chem. 2017 May 16. pii: jbc.M116.762658. doi: 10.1074/jbc.M116.762658.
    PubMed     Abstract available

  91. SEIXAS DA SILVA GS, Melo HM, Lourenco MV, Lyra E Silva NM, et al
    Amyloid-beta oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.
    J Biol Chem. 2017;292:7395-7406.
    PubMed     Abstract available

  92. BRITO-MOREIRA J, Lourenco MV, Oliveira MM, Ribeiro FC, et al
    Interaction of amyloid-beta (Abeta) oligomers with neurexin 2alpha and neuroligin 1 mediates synapse damage and memory loss in mice.
    J Biol Chem. 2017;292:7327-7337.
    PubMed     Abstract available

    March 2017
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