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By B. S. Kamps et al.


  Alzheimer's Disease

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Articles published in J Biol Chem

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Single Articles


    May 2024
  1. YAKOUT DW, Shroff A, Wei W, Thaker V, et al
    Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway.
    J Biol Chem. 2024;300:107237.
    PubMed     Abstract available


    April 2024
  2. DUAN P, El Mammeri N, Hong M
    Milligram-Scale Assembly and NMR Fingerprint of Tau Fibrils Adopting the Alzheimer's Disease Fold.
    J Biol Chem. 2024 Apr 26:107326. doi: 10.1016/j.jbc.2024.107326.
    PubMed     Abstract available


  3. SHIPPY DC, Oliai SF, Ulland TK
    Zinc utilization by microglia in Alzheimer's disease.
    J Biol Chem. 2024 Apr 20:107306. doi: 10.1016/j.jbc.2024.107306.
    PubMed     Abstract available


  4. PERRIN F, Sinha P, Mitchell SPC, Sadek M, et al
    Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites.
    J Biol Chem. 2024;300:107172.
    PubMed     Abstract available


    March 2024
  5. FEOLE M, Pozo Devoto VM, Dragisic N, Arnaiz C, et al
    Swedish Alzheimer's disease variant perturbs activity of retrograde molecular motors and causes widespread derangement of axonal transport pathways.
    J Biol Chem. 2024 Mar 4:107137. doi: 10.1016/j.jbc.2024.107137.
    PubMed     Abstract available


    February 2024
  6. LI Y, Liu D, Zhang X, Rimal S, et al
    RACK1 and IRE1 participate in the translational quality control of amyloid precursor protein in Drosophila models of Alzheimer's disease.
    J Biol Chem. 2024 Feb 2:105719. doi: 10.1016/j.jbc.2024.105719.
    PubMed     Abstract available


    January 2024
  7. KOMMADDI RP, Gowaikar R, Pa H, Diwakar L, et al
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer's disease mouse model.
    J Biol Chem. 2024 Jan 3:105619. doi: 10.1016/j.jbc.2023.105619.
    PubMed     Abstract available


  8. SERNEELS L, Bammens L, Zwijsen A, Tolia A, et al
    Functional and topological analysis of PSENEN, the fourth subunit of the gamma-secretase complex.
    J Biol Chem. 2024;300:105533.
    PubMed     Abstract available


  9. LACROIX MS, Artikis E, Hitt BD, Beaver JD, et al
    Tau seeding without tauopathy.
    J Biol Chem. 2024;300:105545.
    PubMed     Abstract available


    December 2023
  10. JIANG Y, Li L, Wu R, Wu L, et al
    c-Src regulates delta-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.
    J Biol Chem. 2023;299:105462.
    PubMed     Abstract available


  11. COOK I, Leyh TS
    Sterol-activated amyloid beta fibril formation.
    J Biol Chem. 2023;299:105445.
    PubMed     Abstract available


  12. PRATT MR, Vocadlo DJ
    Understanding and exploiting the roles of O-GlcNAc in neurodegenerative diseases.
    J Biol Chem. 2023;299:105411.
    PubMed     Abstract available


  13. WU Y, Thomas GM, Thomsen M, Bahri S, et al
    Lipid environment modulates processivity and kinetics of a presenilin homolog acting on multiple substrates in vitro.
    J Biol Chem. 2023;299:105401.
    PubMed     Abstract available


    November 2023
  14. HITT BD, Gupta A, Singh R, Yang T, et al
    Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds.
    J Biol Chem. 2023;299:105252.
    PubMed     Abstract available


    October 2023
  15. DU Y, Bradshaw WJ, Leisner TM, Annor-Gyamfi JK, et al
    Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
    J Biol Chem. 2023 Oct 20:105382. doi: 10.1016/j.jbc.2023.105382.
    PubMed     Abstract available


    August 2023
  16. XIE J, Wu S, Szadowski H, Min S, et al
    Developmental Pb exposure increases AD risk via altered intracellular Ca(2+) homeostasis in hiPSC-derived cortical neurons.
    J Biol Chem. 2023;299:105023.
    PubMed     Abstract available


  17. KURTH V, Ogorek I, Munch C, Lopez-Rios J, et al
    Pathogenic Abeta production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
    J Biol Chem. 2023;299:104997.
    PubMed     Abstract available


    July 2023
  18. TACHIDA Y, Iijima J, Takahashi K, Suzuki H, et al
    O-GalNAc glycosylation determines intracellular trafficking of APP and Abeta production.
    J Biol Chem. 2023;299:104905.
    PubMed     Abstract available


  19. HOLDEN MR, Krzesinski BJ, Weismiller HA, Shady JR, et al
    MAP2 caps tau fibrils and inhibits aggregation.
    J Biol Chem. 2023;299:104891.
    PubMed     Abstract available


  20. GIBBONS GS, Gould H, Lee VM, Crowe A, et al
    Identification of small molecules and related targets that modulate tau pathology in a seeded primary neuron model.
    J Biol Chem. 2023;299:104876.
    PubMed     Abstract available


  21. TAMBINI MD, Yin T, Yesiltepe M, Breuillaud L, et al
    Abeta43 levels determine the onset of pathological amyloid deposition.
    J Biol Chem. 2023;299:104868.
    PubMed     Abstract available


    June 2023
  22. SERNEELS L, Narlawar R, Perez-Benito L, Municoy M, et al
    Selective inhibitors of the PSEN1-gamma-secretase complex.
    J Biol Chem. 2023;299:104794.
    PubMed     Abstract available


  23. BOYKO S, Surewicz WK
    Domain-specific modulatory effects of phosphomimetic substitutions on liquid-liquid phase separation of tau protein.
    J Biol Chem. 2023;299:104722.
    PubMed     Abstract available


    May 2023
  24. SAWMILLER D, Koyama N, Fujiwara M, Segawa T, et al
    Targeting Apolipoprotein E and N-terminal Amyloid beta-protein Precursor Interaction Improves Cognition and Reduces Amyloid pathology in Alzheimer mice.
    J Biol Chem. 2023 May 19:104846. doi: 10.1016/j.jbc.2023.104846.
    PubMed     Abstract available


  25. KOTIYA D, Leibold N, Verma N, Jicha GA, et al
    Rapid, scalable assay of amylin-beta amyloid co-aggregation in brain tissue and blood.
    J Biol Chem. 2023;299:104682.
    PubMed     Abstract available


  26. TIWARI A, Pradhan S, Sannigrahi A, Mahakud AK, et al
    Interplay of lipid head group and packing defects in driving amyloid-beta-mediated myelin-like model membrane deformation.
    J Biol Chem. 2023;299:104653.
    PubMed     Abstract available


  27. SCHMIDT FC, Fitz K, Feilen LP, Okochi M, et al
    Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the gamma-secretase subunit presenilin.
    J Biol Chem. 2023;299:104626.
    PubMed     Abstract available


    April 2023
  28. LU Y, Huang X, Liang W, Li Y, et al
    Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer's Disease.
    J Biol Chem. 2023 Apr 10:104688. doi: 10.1016/j.jbc.2023.104688.
    PubMed     Abstract available


  29. MATTHES D, de Groot BL
    Molecular dynamics simulations reveal the importance of amyloid-beta oligomer beta-sheet edge conformations in membrane permeabilization.
    J Biol Chem. 2023;299:103034.
    PubMed     Abstract available


  30. DAWKINS E, Derks RJE, Schifferer M, Trambauer J, et al
    Membrane lipid remodeling modulates gamma-secretase processivity.
    J Biol Chem. 2023;299:103027.
    PubMed     Abstract available


    March 2023
  31. MASQUELIER E, Taxon E, Liang SP, Al Sabeh Y, et al
    A new electrochemical method that mimics phosphorylation of the core tau peptide K18 enables kinetic and structural analysis of intermediates and assembly.
    J Biol Chem. 2023;299:103011.
    PubMed     Abstract available


  32. GUI X, Feng S, Li Z, Li Y, et al
    Liquid-liquid phase separation of amyloid-beta oligomers modulates amyloid fibrils formation.
    J Biol Chem. 2023;299:102926.
    PubMed     Abstract available


    January 2023
  33. FERNANDEZ A, Gomez MT, Vidal R
    Lack of ApoE inhibits ADan amyloidosis in a mouse model of familial Danish dementia.
    J Biol Chem. 2023;299:102751.
    PubMed     Abstract available


    December 2022
  34. MAFIMOGHADDAM S, Xu Y, Sherman MB, Orlova EV, et al
    Suppression of amyloid-beta fibril growth by drug-engineered polymorph transformation.
    J Biol Chem. 2022;298:102662.
    PubMed     Abstract available


  35. BUSCH L, Al Taleb Z, Tsai YL, Nguyen VTT, et al
    Amyloid beta and its naturally occurring N-terminal variants are potent activators of human and mouse formyl peptide receptor 1.
    J Biol Chem. 2022;298:102642.
    PubMed     Abstract available


    October 2022
  36. LI T, Yin L, Kang X, Xue W, et al
    TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer's disease-relevant phenotypes in mice.
    J Biol Chem. 2022;298:102649.
    PubMed     Abstract available


  37. KENYAGA JM, Cheng Q, Qiang W
    Early stage beta-amyloid-membrane interactions modulate lipid dynamics and influence structural interfaces and fibrillation.
    J Biol Chem. 2022;298:102491.
    PubMed     Abstract available


  38. IQBAL J, Suarez MD, Yadav PK, Walsh MT, et al
    ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex.
    J Biol Chem. 2022;298:102411.
    PubMed     Abstract available


    August 2022
  39. SONTAG JM, Schuhmacher D, Taleski G, Jordan A, et al
    A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase-mediated tyrosine phosphorylation.
    J Biol Chem. 2022;298:102248.
    PubMed     Abstract available


  40. JANUARIO YC, Eden J, de Oliveira LS, De Pace R, et al
    Clathrin adaptor AP-1-mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments.
    J Biol Chem. 2022;298:102172.
    PubMed     Abstract available


  41. MIRBAHA H, Chen D, Mullapudi V, Terpack SJ, et al
    Seed-competent tau monomer initiates pathology in a tauopathy mouse model.
    J Biol Chem. 2022;298:102163.
    PubMed     Abstract available


    June 2022
  42. ZWIERZCHOWSKI-ZARATE AN, Mendoza-Oliva A, Kashmer OM, Collazo-Lopez JE, et al
    RNA induces unique tau strains and stabilizes Alzheimer's disease seeds.
    J Biol Chem. 2022 Jun 11:102132. doi: 10.1016/j.jbc.2022.102132.
    PubMed     Abstract available


  43. KOLAY S, Vega AR, Dodd DA, Perez VA, et al
    The dual fates of exogenous tau seeds: Lysosomal clearance versus cytoplasmic amplification.
    J Biol Chem. 2022;298:102014.
    PubMed     Abstract available


  44. TABASSUM Z, Tseng JH, Isemann C, Tian X, et al
    Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase.
    J Biol Chem. 2022;298:101977.
    PubMed     Abstract available


  45. HITSCHLER L, Lang T
    The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by alpha-secretase ADAM10.
    J Biol Chem. 2022;298:101911.
    PubMed     Abstract available


  46. TACHIDA Y, Miura S, Muto Y, Takuwa H, et al
    Endothelial expression of human amyloid precursor protein leads to amyloid beta in the blood and induces cerebral amyloid angiopathy in knock-in mice.
    J Biol Chem. 2022;298:101880.
    PubMed     Abstract available


    May 2022
  47. LIANG R, Tian Y, Viles JH
    Cross-seeding of wild-type Amyloid-beta with Arctic but not Italian familial mutants accelerates fibril formation in Alzheimer's Disease.
    J Biol Chem. 2022 May 25:102071. doi: 10.1016/j.jbc.2022.102071.
    PubMed     Abstract available


  48. KOMATSU A, Iida I, Nasu Y, Ito G, et al
    Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum.
    J Biol Chem. 2022;298:101933.
    PubMed     Abstract available


    April 2022
  49. GONZALEZ-GIL A, Porell RN, Fernandes SM, Maenpaa E, et al
    Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease.
    J Biol Chem. 2022 Apr 19:101960. doi: 10.1016/j.jbc.2022.101960.
    PubMed     Abstract available


    March 2022
  50. ZHANG S, Bai P, Lei D, Liang Y, et al
    Degradation and Inhibition of Epigenetic Regulatory Protein BRD4 Exacerbate Alzheimer's Disease-Related Neuropathology in Cell Models.
    J Biol Chem. 2022 Mar 3:101794. doi: 10.1016/j.jbc.2022.101794.
    PubMed     Abstract available


  51. NEDAEI H, Rezaei-Ghaleh N, Giller K, Becker S, et al
    The calcium-free form of atorvastatin inhibits amyloid-beta(1-42) aggregation in vitro.
    J Biol Chem. 2022;298:101662.
    PubMed     Abstract available


    February 2022
  52. PUANGMALAI N, Sengupta U, Bhatt N, Gaikwad S, et al
    Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease.
    J Biol Chem. 2022 Feb 21:101766. doi: 10.1016/j.jbc.2022.101766.
    PubMed     Abstract available


  53. AHMED R, Huang J, Lifshitz R, Martinez Pomier K, et al
    Structural determinants of the interactions of catechins with Abeta oligomers and lipid membranes.
    J Biol Chem. 2022;298:101502.
    PubMed     Abstract available


    January 2022
  54. SHOBO A, James N, Dai D, Rontgen A, et al
    The amyloid-beta1-42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution.
    J Biol Chem. 2022;298:101483.
    PubMed     Abstract available


  55. ACOSTA DM, Mancinelli C, Bracken C, Eliezer D, et al
    Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation.
    J Biol Chem. 2022;298:101442.
    PubMed     Abstract available


    November 2021
  56. IRIZARRY BA, Davis J, Zhu X, Boon BDC, et al
    Human cerebral vascular amyloid contains both antiparallel and parallel in-register Abeta40 fibrils.
    J Biol Chem. 2021;297:101259.
    PubMed     Abstract available


    October 2021
  57. DAI B, Zhong T, Chen ZX, Chen W, et al
    Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
    J Biol Chem. 2021;297:101222.
    PubMed     Abstract available


  58. ISMAEL S, Sindi G, Colvin RA, Lee D, et al
    Activity-dependent release of phosphorylated human tau from Drosophila neurons in primary culture.
    J Biol Chem. 2021;297:101108.
    PubMed     Abstract available


    September 2021
  59. LIU H, Kim C, Haldiman T, Sigurdson CJ, et al
    Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease.
    J Biol Chem. 2021 Sep 29:101267. doi: 10.1016/j.jbc.2021.101267.
    PubMed     Abstract available


  60. NIES SH, Takahashi H, Herber CS, Huttner A, et al
    Spreading of Alzheimer Tau seeds is enhanced by aging and template matching with limited impact of amyloid-beta.
    J Biol Chem. 2021 Sep 1:101159. doi: 10.1016/j.jbc.2021.101159.
    PubMed     Abstract available


  61. YIN T, Yao W, Norris KA, D'Adamio L, et al
    A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission.
    J Biol Chem. 2021;297:101089.
    PubMed     Abstract available


  62. WEISMILLER HA, Holub TJ, Krzesinski BJ, Margittai M, et al
    A thiol-based intramolecular redox switch in four-repeat tau controls fibril assembly and disassembly.
    J Biol Chem. 2021;297:101021.
    PubMed     Abstract available


    August 2021
  63. PERDIGAO C, Barata MA, Burrinha T, Almeida CG, et al
    Alzheimer's disease BIN1 coding variants increase intracellular Abeta levels by interfering with BACE1 recycling.
    J Biol Chem. 2021 Aug 7:101056. doi: 10.1016/j.jbc.2021.101056.
    PubMed     Abstract available


    July 2021
  64. SATO K, Watamura N, Fujioka R, Mihira N, et al
    A 3(rd) generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid beta peptide.
    J Biol Chem. 2021 Jul 27:101004. doi: 10.1016/j.jbc.2021.101004.
    PubMed     Abstract available


  65. VALVERDE A, Dunys J, Lorivel T, Debayle D, et al
    Dipeptidyl peptidase 4 contributes to Alzheimer's disease-like defects in a mouse model and is increased in sporadic Alzheimer's disease brains.
    J Biol Chem. 2021 Jul 12:100963. doi: 10.1016/j.jbc.2021.100963.
    PubMed     Abstract available


  66. KAYED R
    Infectious Etiology and Amyloidosis in Alzheimer's Disease: The Puzzle Continues.
    J Biol Chem. 2021 Jul 1:100936. doi: 10.1016/j.jbc.2021.100936.
    PubMed     Abstract available


    May 2021
  67. BOCHAROVA O, Pandit NP, Molesworth K, Fisher A, et al
    Alzheimer's disease-associated beta-Amyloid does not protect against Herpes Simplex Virus 1 infection in the mouse brain.
    J Biol Chem. 2021 May 27:100845. doi: 10.1016/j.jbc.2021.100845.
    PubMed     Abstract available


    April 2021
  68. VILALTA A, Zhou Y, Sevalle J, Griffin JK, et al
    Wild-type sTREM2 blocks Abeta aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Abeta aggregation.
    J Biol Chem. 2021 Apr 3:100631. doi: 10.1016/j.jbc.2021.100631.
    PubMed     Abstract available


    February 2021
  69. LIU L, Lauro BM, Wolfe MS, Selkoe DJ, et al
    Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate gamma-secretase function in generating Alzheimer-causing Abeta peptides.
    J Biol Chem. 2021 Feb 8:100393. doi: 10.1016/j.jbc.2021.100393.
    PubMed     Abstract available


    January 2021
  70. SOLOVYEV N, El-Khatib AH, Costas-Rodriguez M, Schwab K, et al
    Cu, Fe and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.
    J Biol Chem. 2021 Jan 13:100292. doi: 10.1016/j.jbc.2021.100292.
    PubMed     Abstract available


  71. DEVKOTA S, Williams TD, Wolfe MS
    Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by gamma-secretase to increase amyloid beta-peptides of >45 residues.
    J Biol Chem. 2021 Jan 12:100281. doi: 10.1016/j.jbc.2021.100281.
    PubMed     Abstract available


  72. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2021 Jan 8:100241. doi: 10.1074/jbc.RA120.015327.
    PubMed     Abstract available


  73. CHECLER F, Afram E, Pardossi-Piquard R, Lauritzen I, et al
    Is gamma-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
    J Biol Chem. 2021;296:100489.
    PubMed     Abstract available


  74. SHIELDS LY, Li H, Nguyen K, Kim H, et al
    Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity.
    J Biol Chem. 2021;296:100469.
    PubMed     Abstract available


  75. LEE YH, Im E, Hyun M, Park J, et al
    Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation.
    J Biol Chem. 2021;296:100245.
    PubMed     Abstract available


  76. TALESKI G, Schuhmacher D, Su H, Sontag JM, et al
    Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.
    J Biol Chem. 2021;296:100237.
    PubMed     Abstract available


  77. REYES-RUIZ JM, Nakajima R, Baghallab I, Goldschmidt L, et al
    An "epitomic" analysis of the specificity of conformation-dependent, anti-Ass amyloid monoclonal antibodies.
    J Biol Chem. 2021;296:100168.
    PubMed     Abstract available


  78. ABREHA MH, Ojelade S, Dammer EB, McEachin ZT, et al
    TBK1 interacts with tau and enhances neurodegeneration in tauopathy.
    J Biol Chem. 2021;296:100760.
    PubMed     Abstract available


  79. KONIG AS, Rosener NS, Gremer L, Tusche M, et al
    Structural details of amyloid beta oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy.
    J Biol Chem. 2021;296:100499.
    PubMed     Abstract available


  80. ROBERTS JP, Stokoe SA, Sathler MF, Nichols RA, et al
    Selective coactivation of alpha7- and alpha4beta2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction.
    J Biol Chem. 2021;296:100402.
    PubMed     Abstract available


    December 2020
  81. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2020 Dec 29. pii: RA120.015327. doi: 10.1074/jbc.RA120.015327.
    PubMed     Abstract available


  82. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020;295:17138-17147.
    PubMed     Abstract available


    November 2020
  83. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020;296:100089.
    PubMed     Abstract available


  84. LEI P, Ayton S, Bush AI
    The Essential Elements of Alzheimer's Disease.
    J Biol Chem. 2020 Nov 20. pii: REV120.008207. doi: 10.1074/jbc.REV120.008207.
    PubMed     Abstract available


  85. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020 Nov 16. pii: RA120.016395. doi: 10.1074/jbc.RA120.016395.
    PubMed     Abstract available


    October 2020
  86. MAULIK M, Vasan L, Bose A, Dutta Chowdhury S, et al
    Amyloid-beta regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes.
    J Biol Chem. 2020;295:15097-15111.
    PubMed     Abstract available


  87. CAO Q, Anderson DH, Liang WY, Chou J, et al
    The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.
    J Biol Chem. 2020;295:14015-14024.
    PubMed     Abstract available


  88. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule Affinity Regulating Kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020 Oct 5. pii: RA120.014420. doi: 10.1074/jbc.RA120.014420.
    PubMed     Abstract available


  89. GU J, Xu W, Jin N, Li L, et al
    Truncation of Tau selectively facilitates its pathological activities.
    J Biol Chem. 2020;295:13812-13828.
    PubMed     Abstract available


    September 2020
  90. KAESER G, Chun J
    Brain cell somatic gene recombination and its phylogenetic foundations.
    J Biol Chem. 2020;295:12786-12795.
    PubMed     Abstract available


    July 2020
  91. GOTOH N, Saito Y, Hata S, Saito H, et al
    Amyloidogenic processing of amyloid beta protein precursor (APP) is enhanced in the brains of alcadein alpha-deficient mice.
    J Biol Chem. 2020;295:9650-9662.
    PubMed     Abstract available


  92. NACHMAN E, Wentink AS, Madiona K, Bousset L, et al
    Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
    J Biol Chem. 2020;295:9676-9690.
    PubMed     Abstract available


  93. CROOKS EJ, Irizarry BA, Ziliox M, Kawakami T, et al
    Copper stabilizes antiparallel beta-sheet fibrils of the amyloid beta40 (Abeta40)-Iowa variant.
    J Biol Chem. 2020;295:8914-8927.
    PubMed     Abstract available


    May 2020
  94. WALLIN C, Jarvet J, Biverstal H, Warmlander S, et al
    Metal ion coordination delays amyloid-beta peptide self-assembly by forming an aggregation-inert complex.
    J Biol Chem. 2020;295:7224-7234.
    PubMed     Abstract available


  95. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42 and high Abeta43.
    J Biol Chem. 2020;295:7442-7451.
    PubMed     Abstract available


  96. SINGH V, Xu L, Boyko S, Surewicz K, et al
    Zinc promotes liquid-liquid phase separation of tau protein.
    J Biol Chem. 2020;295:5850-5856.
    PubMed     Abstract available


    March 2020
  97. CROWE A, Henderson MJ, Anderson J, Titus SA, et al
    Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
    J Biol Chem. 2020;295:4001-4013.
    PubMed     Abstract available


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