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Alzheimer's Disease

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March 2026
1. MON F, Straub JE
   Structural and mechanistic characterization of heparin interactions with tau fibrils.
   J Biol Chem. 2026;302:111153.
   PubMed     Abstract available
   
   
   February 2026
2. TSAKA G, Pages AM, De Sousa CB, Lammertyn J, et al
   Conformation-specific monoclonal antibodies reveal early Tau structural intermediates in Alzheimer's disease.
   J Biol Chem. 2026 Feb 3:111221. doi: 10.1016/j.jbc.2026.111221.
   PubMed     Abstract available
   
   
   
3. FAZELI E, Jan A, Huber AK, Jensen AMG, et al
   A luminescent reporter assay to quantify SORL1 ectodomain shedding and retromer-dependent endosome recycling activity.
   J Biol Chem. 2026;302:111136.
   PubMed     Abstract available
   
   
   
4. EALY A, Serapiglia AM, Panicker N
   Sterile innate immune mechanisms in neurodegenerative diseases.
   J Biol Chem. 2026;302:111039.
   PubMed     Abstract available
   
   
   January 2026
5. SALVO MA, Cuddy LK, Prokopenko D, Watkins E, et al
   Alzheimer's disease-linked ACE variants increase ACE1 catalytic activity and production of angiotensin II.
   J Biol Chem. 2026 Jan 20:111171. doi: 10.1016/j.jbc.2026.111171.
   PubMed     Abstract available
   
   
   December 2025
6. WU JW, Titterton K, Sebastian R, Romanul N, et al
   Development of a robust, physiologically relevant neuronal tau aggregation assay for tau-related drug discovery.
   J Biol Chem. 2025;301:110853.
   PubMed     Abstract available
   
   
   November 2025
7. KATSINELOS T, Lovestam S, Qi C, Ryskeldi-Falcon B, et al
   Seeding biosensor cell line that reproduces the Alzheimer tau fold.
   J Biol Chem. 2025 Nov 17:110952. doi: 10.1016/j.jbc.2025.110952.
   PubMed     Abstract available
   
   
   
8. LUNDIN B, Wieckiewicz N, Yokomizo M, Sadek M, et al
   APP family is a regulator of endo-lysosomal membrane vulnerability.
   J Biol Chem. 2025;301:110774.
   PubMed     Abstract available
   
   
   
9. ZHANG DY, Wang J, Huang G, Dokholyan M, et al
   Apolipoprotein E (APOE) regulates the transport of monosialotetrahexosylganglioside (GM1).
   J Biol Chem. 2025;301:110778.
   PubMed     Abstract available
   
   
   October 2025
10. AMBAREEN N, Gharami K, Mondal A, Sarkar UA, et al
    Sertad1 is elevated and plays a necessary role in neuron loss and cognitive impairment in a mouse model of Alzheimer's disease.
    J Biol Chem. 2025 Oct 29:110875. doi: 10.1016/j.jbc.2025.110875.
    PubMed     Abstract available
    
    
    September 2025
11. SHIVKUMAR A, Berg KR, Sibucao KC, Leriche G, et al
    Nootropic benzothiazoles promote dendritic spine formation by targeting fascin-1.
    J Biol Chem. 2025;301:110572.
    PubMed     Abstract available
    
    
    August 2025
12. BLAZIER DM, Lewandowski EM, Ram N, Zhang X, et al
    A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap.
    J Biol Chem. 2025 Aug 30:110665. doi: 10.1016/j.jbc.2025.110665.
    PubMed     Abstract available
    
    
    
13. ORMAZABAL P, Gherardelli C, Pinto C, Servili E, et al
    Andrographolide modulates glucose metabolism in visceral adipose tissue in an Alzheimer's disease obese mouse model.
    J Biol Chem. 2025 Aug 16:110607. doi: 10.1016/j.jbc.2025.110607.
    PubMed     Abstract available
    
    
    
14. WU J, Chai K, Tu Y, Fang K, et al
    Multifunctional Molecular Agent for Tau-targeted Combinational Therapy of Alzheimer's Disease.
    J Biol Chem. 2025 Aug 12:110583. doi: 10.1016/j.jbc.2025.110583.
    PubMed     Abstract available
    
    
    
15. NYBERG E, Konings SC, Lindblom N, Israelsson B, et al
    Neuronal endolysosomal alterations induced by Apolipoprotein E4 emerge over time in primary neurons.
    J Biol Chem. 2025;301:110479.
    PubMed     Abstract available
    
    
    July 2025
16. KURKELA M, Dvorakova L, Koivisto H, Uusitalo M, et al
    Targeting HIF-P4H-2 in APP/PS1 Alzheimer's mouse model improves glucose metabolism, reduces dystrophic neurites and maintains exploratory activity.
    J Biol Chem. 2025 Jul 1:110432. doi: 10.1016/j.jbc.2025.110432.
    PubMed     Abstract available
    
    
    June 2025
17. ITO G, Utsunomiya-Tate N
    Discovery and biochemical characterization of the D-aspartyl endopeptidase activity of the serine protease LACTB.
    J Biol Chem. 2025;301:108549.
    PubMed     Abstract available
    
    
    May 2025
18. SUN L, Liu J, Lu M, Zhou Y, et al
    Inactivation of SIAH-1 E3 ligase attenuates Abeta toxicity by suppressing ubiquitin-dependent DVE-1 degradation in C. elegans models of Alzheimer's disease.
    J Biol Chem. 2025 May 9:110226. doi: 10.1016/j.jbc.2025.110226.
    PubMed     Abstract available
    
    
    April 2025
19. SUN C, Zhou K, DePaola P 4th, Li C, et al
    Structural basis of a distinct alpha-synuclein strain that promotes tau inclusion in neurons.
    J Biol Chem. 2025;301:108351.
    PubMed     Abstract available
    
    
    March 2025
20. RAHMAN MW, Sharma P, Chattopadhyay T, Saroja SR, et al
    Distinct neuronal vulnerability and metabolic dysfunctions are characteristic features of fast-progressing Alzheimer's patients with Lewy bodies.
    J Biol Chem. 2025 Mar 10:108396. doi: 10.1016/j.jbc.2025.108396.
    PubMed     Abstract available
    
    
    
21. ALHADIDY MM, Stemmer PM, Kanaan NM
    O-GlcNAc modification differentially regulates microtubule binding and pathological conformations of tau isoforms in vitro.
    J Biol Chem. 2025;301:108263.
    PubMed     Abstract available
    
    
    
22. HUANG M, McEwan WA
    Sensitive detection and propagation of brain-derived tau assemblies in HEK293-based wild-type tau seeding assays.
    J Biol Chem. 2025;301:108245.
    PubMed     Abstract available
    
    
    February 2025
23. CARR AJ, Hajicek N, Tsai AP, Acharya PP, et al
    A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-gamma2 to treat Alzheimer's disease.
    J Biol Chem. 2025 Feb 25:108356. doi: 10.1016/j.jbc.2025.108356.
    PubMed     Abstract available
    
    
    January 2025
24. KLINGSTEDT T, Shirani H, Parvin F, Nystrom S, et al
    Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-beta deposits.
    J Biol Chem. 2025;301:108032.
    PubMed     Abstract available
    
    
    December 2024
25. TAVALIN SJ
    Familial Alzheimer's disease mutations in amyloid precursor protein impair calcineurin signaling to NMDA receptors.
    J Biol Chem. 2024 Dec 26:108147. doi: 10.1016/j.jbc.2024.108147.
    PubMed     Abstract available
    
    
    
26. MATSUMOTO M, Gomez-Soler M, Lombardi S, Lechtenberg BC, et al
    Missense Mutations of the Ephrin Receptor EPHA1 Associated with Alzheimer's Disease Disrupt Receptor Signaling Functions.
    J Biol Chem. 2024 Dec 18:108099. doi: 10.1016/j.jbc.2024.108099.
    PubMed     Abstract available
    
    
    October 2024
27. LIN J, Yuan Y, Huang C, Zi J, et al
    TFEB agonist clomiphene citrate activates the autophagy-lysosomal pathway and ameliorates Alzheimer's disease symptoms in mice.
    J Biol Chem. 2024 Oct 23:107929. doi: 10.1016/j.jbc.2024.107929.
    PubMed     Abstract available
    
    
    
28. LIN D, Kaye S, Chen M, Lyanna A, et al
    Transcriptome and proteome profiling reveals TREM2-dependent and -independent glial response and metabolic perturbation in an Alzheimer's mouse model.
    J Biol Chem. 2024 Oct 10:107874. doi: 10.1016/j.jbc.2024.107874.
    PubMed     Abstract available
    
    
    September 2024
29. CHAUHAN M, Singh K, Chongtham C, A G A, et al
    miR-449a mediated repression of the cell cycle machinery prevents neuronal apoptosis.
    J Biol Chem. 2024;300:107698.
    PubMed     Abstract available
    
    
    
30. MCMILLAN IO, Liang L, Su G, Song X, et al
    TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid.
    J Biol Chem. 2024;300:107691.
    PubMed     Abstract available
    
    
    
31. ZHANG Q, Singh P, Peng DW, Peng EY, et al
    Proactive M2 blockade prevents cognitive decline in GRK5-deficient APP transgenic mice via enhancing cholinergic neuronal resilience.
    J Biol Chem. 2024;300:107619.
    PubMed     Abstract available
    
    
    August 2024
32. DUAN P, Dregni AJ, Xu H, Changolkar L, et al
    Alzheimer's Disease Seeded Tau Forms Paired Helical Filaments Yet Lacks Seeding Potential.
    J Biol Chem. 2024 Aug 28:107730. doi: 10.1016/j.jbc.2024.107730.
    PubMed     Abstract available
    
    
    
33. PU Y, Yang J, Pan Q, Li C, et al
    MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway.
    J Biol Chem. 2024;300:107530.
    PubMed     Abstract available
    
    
    June 2024
34. COOPER JM, Lathuiliere A, Su EJ, Song Y, et al
    SORL1 is a receptor for tau that promotes tau seeding.
    J Biol Chem. 2024;300:107313.
    PubMed     Abstract available
    
    
    May 2024
35. YAKOUT DW, Shroff A, Wei W, Thaker V, et al
    Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway.
    J Biol Chem. 2024;300:107237.
    PubMed     Abstract available
    
    
    April 2024
36. DUAN P, El Mammeri N, Hong M
    Milligram-Scale Assembly and NMR Fingerprint of Tau Fibrils Adopting the Alzheimer's Disease Fold.
    J Biol Chem. 2024 Apr 26:107326. doi: 10.1016/j.jbc.2024.107326.
    PubMed     Abstract available
    
    
    
37. SHIPPY DC, Oliai SF, Ulland TK
    Zinc utilization by microglia in Alzheimer's disease.
    J Biol Chem. 2024 Apr 20:107306. doi: 10.1016/j.jbc.2024.107306.
    PubMed     Abstract available
    
    
    
38. PERRIN F, Sinha P, Mitchell SPC, Sadek M, et al
    Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites.
    J Biol Chem. 2024;300:107172.
    PubMed     Abstract available
    
    
    March 2024
39. FEOLE M, Pozo Devoto VM, Dragisic N, Arnaiz C, et al
    Swedish Alzheimer's disease variant perturbs activity of retrograde molecular motors and causes widespread derangement of axonal transport pathways.
    J Biol Chem. 2024 Mar 4:107137. doi: 10.1016/j.jbc.2024.107137.
    PubMed     Abstract available
    
    
    February 2024
40. LI Y, Liu D, Zhang X, Rimal S, et al
    RACK1 and IRE1 participate in the translational quality control of amyloid precursor protein in Drosophila models of Alzheimer's disease.
    J Biol Chem. 2024 Feb 2:105719. doi: 10.1016/j.jbc.2024.105719.
    PubMed     Abstract available
    
    
    January 2024
41. KOMMADDI RP, Gowaikar R, Pa H, Diwakar L, et al
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer's disease mouse model.
    J Biol Chem. 2024 Jan 3:105619. doi: 10.1016/j.jbc.2023.105619.
    PubMed     Abstract available
    
    
    
42. SERNEELS L, Bammens L, Zwijsen A, Tolia A, et al
    Functional and topological analysis of PSENEN, the fourth subunit of the gamma-secretase complex.
    J Biol Chem. 2024;300:105533.
    PubMed     Abstract available
    
    
    
43. LACROIX MS, Artikis E, Hitt BD, Beaver JD, et al
    Tau seeding without tauopathy.
    J Biol Chem. 2024;300:105545.
    PubMed     Abstract available
    
    
    December 2023
44. JIANG Y, Li L, Wu R, Wu L, et al
    c-Src regulates delta-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.
    J Biol Chem. 2023;299:105462.
    PubMed     Abstract available
    
    
    
45. COOK I, Leyh TS
    Sterol-activated amyloid beta fibril formation.
    J Biol Chem. 2023;299:105445.
    PubMed     Abstract available
    
    
    
46. PRATT MR, Vocadlo DJ
    Understanding and exploiting the roles of O-GlcNAc in neurodegenerative diseases.
    J Biol Chem. 2023;299:105411.
    PubMed     Abstract available
    
    
    
47. WU Y, Thomas GM, Thomsen M, Bahri S, et al
    Lipid environment modulates processivity and kinetics of a presenilin homolog acting on multiple substrates in vitro.
    J Biol Chem. 2023;299:105401.
    PubMed     Abstract available
    
    
    November 2023
48. HITT BD, Gupta A, Singh R, Yang T, et al
    Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds.
    J Biol Chem. 2023;299:105252.
    PubMed     Abstract available
    
    
    October 2023
49. DU Y, Bradshaw WJ, Leisner TM, Annor-Gyamfi JK, et al
    Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
    J Biol Chem. 2023 Oct 20:105382. doi: 10.1016/j.jbc.2023.105382.
    PubMed     Abstract available
    
    
    
50. CRUCETA L, Sun Y, Kenyaga JM, Ostrovsky D, et al
    Modulation of aggregation and structural polymorphisms of beta-amyloid fibrils in cellular environments by pyroglutamate-3 variant cross-seeding.
    J Biol Chem. 2023;299:105196.
    PubMed     Abstract available
    
    
    August 2023
51. XIE J, Wu S, Szadowski H, Min S, et al
    Developmental Pb exposure increases AD risk via altered intracellular Ca(2+) homeostasis in hiPSC-derived cortical neurons.
    J Biol Chem. 2023;299:105023.
    PubMed     Abstract available
    
    
    
52. KURTH V, Ogorek I, Munch C, Lopez-Rios J, et al
    Pathogenic Abeta production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
    J Biol Chem. 2023;299:104997.
    PubMed     Abstract available
    
    
    July 2023
53. TACHIDA Y, Iijima J, Takahashi K, Suzuki H, et al
    O-GalNAc glycosylation determines intracellular trafficking of APP and Abeta production.
    J Biol Chem. 2023;299:104905.
    PubMed     Abstract available
    
    
    
54. HOLDEN MR, Krzesinski BJ, Weismiller HA, Shady JR, et al
    MAP2 caps tau fibrils and inhibits aggregation.
    J Biol Chem. 2023;299:104891.
    PubMed     Abstract available
    
    
    
55. GIBBONS GS, Gould H, Lee VM, Crowe A, et al
    Identification of small molecules and related targets that modulate tau pathology in a seeded primary neuron model.
    J Biol Chem. 2023;299:104876.
    PubMed     Abstract available
    
    
    
56. TAMBINI MD, Yin T, Yesiltepe M, Breuillaud L, et al
    Abeta43 levels determine the onset of pathological amyloid deposition.
    J Biol Chem. 2023;299:104868.
    PubMed     Abstract available
    
    
    June 2023
57. SERNEELS L, Narlawar R, Perez-Benito L, Municoy M, et al
    Selective inhibitors of the PSEN1-gamma-secretase complex.
    J Biol Chem. 2023;299:104794.
    PubMed     Abstract available
    
    
    
58. BOYKO S, Surewicz WK
    Domain-specific modulatory effects of phosphomimetic substitutions on liquid-liquid phase separation of tau protein.
    J Biol Chem. 2023;299:104722.
    PubMed     Abstract available
    
    
    May 2023
59. SAWMILLER D, Koyama N, Fujiwara M, Segawa T, et al
    Targeting Apolipoprotein E and N-terminal Amyloid beta-protein Precursor Interaction Improves Cognition and Reduces Amyloid pathology in Alzheimer mice.
    J Biol Chem. 2023 May 19:104846. doi: 10.1016/j.jbc.2023.104846.
    PubMed     Abstract available
    
    
    
60. KOTIYA D, Leibold N, Verma N, Jicha GA, et al
    Rapid, scalable assay of amylin-beta amyloid co-aggregation in brain tissue and blood.
    J Biol Chem. 2023;299:104682.
    PubMed     Abstract available
    
    
    
61. TIWARI A, Pradhan S, Sannigrahi A, Mahakud AK, et al
    Interplay of lipid head group and packing defects in driving amyloid-beta-mediated myelin-like model membrane deformation.
    J Biol Chem. 2023;299:104653.
    PubMed     Abstract available
    
    
    
62. SCHMIDT FC, Fitz K, Feilen LP, Okochi M, et al
    Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the gamma-secretase subunit presenilin.
    J Biol Chem. 2023;299:104626.
    PubMed     Abstract available
    
    
    April 2023
63. LU Y, Huang X, Liang W, Li Y, et al
    Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer's Disease.
    J Biol Chem. 2023 Apr 10:104688. doi: 10.1016/j.jbc.2023.104688.
    PubMed     Abstract available
    
    
    
64. MATTHES D, de Groot BL
    Molecular dynamics simulations reveal the importance of amyloid-beta oligomer beta-sheet edge conformations in membrane permeabilization.
    J Biol Chem. 2023;299:103034.
    PubMed     Abstract available
    
    
    
65. DAWKINS E, Derks RJE, Schifferer M, Trambauer J, et al
    Membrane lipid remodeling modulates gamma-secretase processivity.
    J Biol Chem. 2023;299:103027.
    PubMed     Abstract available
    
    
    March 2023
66. MASQUELIER E, Taxon E, Liang SP, Al Sabeh Y, et al
    A new electrochemical method that mimics phosphorylation of the core tau peptide K18 enables kinetic and structural analysis of intermediates and assembly.
    J Biol Chem. 2023;299:103011.
    PubMed     Abstract available
    
    
    
67. GUI X, Feng S, Li Z, Li Y, et al
    Liquid-liquid phase separation of amyloid-beta oligomers modulates amyloid fibrils formation.
    J Biol Chem. 2023;299:102926.
    PubMed     Abstract available
    
    

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