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Articles published in J Biol Chem

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    October 2022
  1. KENYAGA JM, Cheng Q, Qiang W
    Early stage beta-amyloid-membrane interactions modulate lipid dynamics and influence structural interfaces and fibrillation.
    J Biol Chem. 2022;298:102491.
    PubMed     Abstract available


  2. IQBAL J, Suarez MD, Yadav PK, Walsh MT, et al
    ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex.
    J Biol Chem. 2022;298:102411.
    PubMed     Abstract available


    August 2022
  3. SONTAG JM, Schuhmacher D, Taleski G, Jordan A, et al
    A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase-mediated tyrosine phosphorylation.
    J Biol Chem. 2022;298:102248.
    PubMed     Abstract available


  4. JANUARIO YC, Eden J, de Oliveira LS, De Pace R, et al
    Clathrin adaptor AP-1-mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments.
    J Biol Chem. 2022;298:102172.
    PubMed     Abstract available


  5. MIRBAHA H, Chen D, Mullapudi V, Terpack SJ, et al
    Seed-competent tau monomer initiates pathology in a tauopathy mouse model.
    J Biol Chem. 2022;298:102163.
    PubMed     Abstract available


    June 2022
  6. ZWIERZCHOWSKI-ZARATE AN, Mendoza-Oliva A, Kashmer OM, Collazo-Lopez JE, et al
    RNA induces unique tau strains and stabilizes Alzheimer's disease seeds.
    J Biol Chem. 2022 Jun 11:102132. doi: 10.1016/j.jbc.2022.102132.
    PubMed     Abstract available


  7. KOLAY S, Vega AR, Dodd DA, Perez VA, et al
    The dual fates of exogenous tau seeds: Lysosomal clearance versus cytoplasmic amplification.
    J Biol Chem. 2022;298:102014.
    PubMed     Abstract available


  8. TABASSUM Z, Tseng JH, Isemann C, Tian X, et al
    Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase.
    J Biol Chem. 2022;298:101977.
    PubMed     Abstract available


  9. HITSCHLER L, Lang T
    The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by alpha-secretase ADAM10.
    J Biol Chem. 2022;298:101911.
    PubMed     Abstract available


  10. TACHIDA Y, Miura S, Muto Y, Takuwa H, et al
    Endothelial expression of human amyloid precursor protein leads to amyloid beta in the blood and induces cerebral amyloid angiopathy in knock-in mice.
    J Biol Chem. 2022;298:101880.
    PubMed     Abstract available


    May 2022
  11. LIANG R, Tian Y, Viles JH
    Cross-seeding of wild-type Amyloid-beta with Arctic but not Italian familial mutants accelerates fibril formation in Alzheimer's Disease.
    J Biol Chem. 2022 May 25:102071. doi: 10.1016/j.jbc.2022.102071.
    PubMed     Abstract available


  12. KOMATSU A, Iida I, Nasu Y, Ito G, et al
    Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum.
    J Biol Chem. 2022;298:101933.
    PubMed     Abstract available


    April 2022
  13. GONZALEZ-GIL A, Porell RN, Fernandes SM, Maenpaa E, et al
    Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease.
    J Biol Chem. 2022 Apr 19:101960. doi: 10.1016/j.jbc.2022.101960.
    PubMed     Abstract available


    March 2022
  14. ZHANG S, Bai P, Lei D, Liang Y, et al
    Degradation and Inhibition of Epigenetic Regulatory Protein BRD4 Exacerbate Alzheimer's Disease-Related Neuropathology in Cell Models.
    J Biol Chem. 2022 Mar 3:101794. doi: 10.1016/j.jbc.2022.101794.
    PubMed     Abstract available


  15. NEDAEI H, Rezaei-Ghaleh N, Giller K, Becker S, et al
    The calcium-free form of atorvastatin inhibits amyloid-beta(1-42) aggregation in vitro.
    J Biol Chem. 2022;298:101662.
    PubMed     Abstract available


    February 2022
  16. PUANGMALAI N, Sengupta U, Bhatt N, Gaikwad S, et al
    Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease.
    J Biol Chem. 2022 Feb 21:101766. doi: 10.1016/j.jbc.2022.101766.
    PubMed     Abstract available


  17. AHMED R, Huang J, Lifshitz R, Martinez Pomier K, et al
    Structural determinants of the interactions of catechins with Abeta oligomers and lipid membranes.
    J Biol Chem. 2022;298:101502.
    PubMed     Abstract available


    January 2022
  18. SHOBO A, James N, Dai D, Rontgen A, et al
    The amyloid-beta1-42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution.
    J Biol Chem. 2022;298:101483.
    PubMed     Abstract available


  19. ACOSTA DM, Mancinelli C, Bracken C, Eliezer D, et al
    Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation.
    J Biol Chem. 2022;298:101442.
    PubMed     Abstract available


    November 2021
  20. IRIZARRY BA, Davis J, Zhu X, Boon BDC, et al
    Human cerebral vascular amyloid contains both antiparallel and parallel in-register Abeta40 fibrils.
    J Biol Chem. 2021;297:101259.
    PubMed     Abstract available


    October 2021
  21. DAI B, Zhong T, Chen ZX, Chen W, et al
    Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
    J Biol Chem. 2021;297:101222.
    PubMed     Abstract available


  22. ISMAEL S, Sindi G, Colvin RA, Lee D, et al
    Activity-dependent release of phosphorylated human tau from Drosophila neurons in primary culture.
    J Biol Chem. 2021;297:101108.
    PubMed     Abstract available


    September 2021
  23. LIU H, Kim C, Haldiman T, Sigurdson CJ, et al
    Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease.
    J Biol Chem. 2021 Sep 29:101267. doi: 10.1016/j.jbc.2021.101267.
    PubMed     Abstract available


  24. NIES SH, Takahashi H, Herber CS, Huttner A, et al
    Spreading of Alzheimer Tau seeds is enhanced by aging and template matching with limited impact of amyloid-beta.
    J Biol Chem. 2021 Sep 1:101159. doi: 10.1016/j.jbc.2021.101159.
    PubMed     Abstract available


  25. YIN T, Yao W, Norris KA, D'Adamio L, et al
    A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission.
    J Biol Chem. 2021;297:101089.
    PubMed     Abstract available


  26. WEISMILLER HA, Holub TJ, Krzesinski BJ, Margittai M, et al
    A thiol-based intramolecular redox switch in four-repeat tau controls fibril assembly and disassembly.
    J Biol Chem. 2021;297:101021.
    PubMed     Abstract available


    August 2021
  27. PERDIGAO C, Barata MA, Burrinha T, Almeida CG, et al
    Alzheimer's disease BIN1 coding variants increase intracellular Abeta levels by interfering with BACE1 recycling.
    J Biol Chem. 2021 Aug 7:101056. doi: 10.1016/j.jbc.2021.101056.
    PubMed     Abstract available


    July 2021
  28. SATO K, Watamura N, Fujioka R, Mihira N, et al
    A 3(rd) generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid beta peptide.
    J Biol Chem. 2021 Jul 27:101004. doi: 10.1016/j.jbc.2021.101004.
    PubMed     Abstract available


  29. VALVERDE A, Dunys J, Lorivel T, Debayle D, et al
    Dipeptidyl peptidase 4 contributes to Alzheimer's disease-like defects in a mouse model and is increased in sporadic Alzheimer's disease brains.
    J Biol Chem. 2021 Jul 12:100963. doi: 10.1016/j.jbc.2021.100963.
    PubMed     Abstract available


  30. KAYED R
    Infectious Etiology and Amyloidosis in Alzheimer's Disease: The Puzzle Continues.
    J Biol Chem. 2021 Jul 1:100936. doi: 10.1016/j.jbc.2021.100936.
    PubMed     Abstract available


    May 2021
  31. BOCHAROVA O, Pandit NP, Molesworth K, Fisher A, et al
    Alzheimer's disease-associated beta-Amyloid does not protect against Herpes Simplex Virus 1 infection in the mouse brain.
    J Biol Chem. 2021 May 27:100845. doi: 10.1016/j.jbc.2021.100845.
    PubMed     Abstract available


    April 2021
  32. VILALTA A, Zhou Y, Sevalle J, Griffin JK, et al
    Wild-type sTREM2 blocks Abeta aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Abeta aggregation.
    J Biol Chem. 2021 Apr 3:100631. doi: 10.1016/j.jbc.2021.100631.
    PubMed     Abstract available


    February 2021
  33. LIU L, Lauro BM, Wolfe MS, Selkoe DJ, et al
    Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate gamma-secretase function in generating Alzheimer-causing Abeta peptides.
    J Biol Chem. 2021 Feb 8:100393. doi: 10.1016/j.jbc.2021.100393.
    PubMed     Abstract available


    January 2021
  34. SOLOVYEV N, El-Khatib AH, Costas-Rodriguez M, Schwab K, et al
    Cu, Fe and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.
    J Biol Chem. 2021 Jan 13:100292. doi: 10.1016/j.jbc.2021.100292.
    PubMed     Abstract available


  35. DEVKOTA S, Williams TD, Wolfe MS
    Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by gamma-secretase to increase amyloid beta-peptides of >45 residues.
    J Biol Chem. 2021 Jan 12:100281. doi: 10.1016/j.jbc.2021.100281.
    PubMed     Abstract available


  36. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2021 Jan 8:100241. doi: 10.1074/jbc.RA120.015327.
    PubMed     Abstract available


  37. CHECLER F, Afram E, Pardossi-Piquard R, Lauritzen I, et al
    Is gamma-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
    J Biol Chem. 2021;296:100489.
    PubMed     Abstract available


  38. SHIELDS LY, Li H, Nguyen K, Kim H, et al
    Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity.
    J Biol Chem. 2021;296:100469.
    PubMed     Abstract available


  39. LEE YH, Im E, Hyun M, Park J, et al
    Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation.
    J Biol Chem. 2021;296:100245.
    PubMed     Abstract available


  40. TALESKI G, Schuhmacher D, Su H, Sontag JM, et al
    Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.
    J Biol Chem. 2021;296:100237.
    PubMed     Abstract available


  41. REYES-RUIZ JM, Nakajima R, Baghallab I, Goldschmidt L, et al
    An "epitomic" analysis of the specificity of conformation-dependent, anti-Ass amyloid monoclonal antibodies.
    J Biol Chem. 2021;296:100168.
    PubMed     Abstract available


  42. ABREHA MH, Ojelade S, Dammer EB, McEachin ZT, et al
    TBK1 interacts with tau and enhances neurodegeneration in tauopathy.
    J Biol Chem. 2021;296:100760.
    PubMed     Abstract available


  43. KONIG AS, Rosener NS, Gremer L, Tusche M, et al
    Structural details of amyloid beta oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy.
    J Biol Chem. 2021;296:100499.
    PubMed     Abstract available


  44. ROBERTS JP, Stokoe SA, Sathler MF, Nichols RA, et al
    Selective coactivation of alpha7- and alpha4beta2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction.
    J Biol Chem. 2021;296:100402.
    PubMed     Abstract available


    December 2020
  45. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2020 Dec 29. pii: RA120.015327. doi: 10.1074/jbc.RA120.015327.
    PubMed     Abstract available


  46. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020;295:17138-17147.
    PubMed     Abstract available


    November 2020
  47. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020;296:100089.
    PubMed     Abstract available


  48. LEI P, Ayton S, Bush AI
    The Essential Elements of Alzheimer's Disease.
    J Biol Chem. 2020 Nov 20. pii: REV120.008207. doi: 10.1074/jbc.REV120.008207.
    PubMed     Abstract available


  49. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020 Nov 16. pii: RA120.016395. doi: 10.1074/jbc.RA120.016395.
    PubMed     Abstract available


    October 2020
  50. MAULIK M, Vasan L, Bose A, Dutta Chowdhury S, et al
    Amyloid-beta regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes.
    J Biol Chem. 2020;295:15097-15111.
    PubMed     Abstract available


  51. CAO Q, Anderson DH, Liang WY, Chou J, et al
    The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.
    J Biol Chem. 2020;295:14015-14024.
    PubMed     Abstract available


  52. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule Affinity Regulating Kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020 Oct 5. pii: RA120.014420. doi: 10.1074/jbc.RA120.014420.
    PubMed     Abstract available


  53. GU J, Xu W, Jin N, Li L, et al
    Truncation of Tau selectively facilitates its pathological activities.
    J Biol Chem. 2020;295:13812-13828.
    PubMed     Abstract available


    September 2020
  54. KAESER G, Chun J
    Brain cell somatic gene recombination and its phylogenetic foundations.
    J Biol Chem. 2020;295:12786-12795.
    PubMed     Abstract available


    July 2020
  55. GOTOH N, Saito Y, Hata S, Saito H, et al
    Amyloidogenic processing of amyloid beta protein precursor (APP) is enhanced in the brains of alcadein alpha-deficient mice.
    J Biol Chem. 2020;295:9650-9662.
    PubMed     Abstract available


  56. NACHMAN E, Wentink AS, Madiona K, Bousset L, et al
    Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
    J Biol Chem. 2020;295:9676-9690.
    PubMed     Abstract available


  57. CROOKS EJ, Irizarry BA, Ziliox M, Kawakami T, et al
    Copper stabilizes antiparallel beta-sheet fibrils of the amyloid beta40 (Abeta40)-Iowa variant.
    J Biol Chem. 2020;295:8914-8927.
    PubMed     Abstract available


    May 2020
  58. WALLIN C, Jarvet J, Biverstal H, Warmlander S, et al
    Metal ion coordination delays amyloid-beta peptide self-assembly by forming an aggregation-inert complex.
    J Biol Chem. 2020;295:7224-7234.
    PubMed     Abstract available


  59. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42 and high Abeta43.
    J Biol Chem. 2020;295:7442-7451.
    PubMed     Abstract available


  60. SINGH V, Xu L, Boyko S, Surewicz K, et al
    Zinc promotes liquid-liquid phase separation of tau protein.
    J Biol Chem. 2020;295:5850-5856.
    PubMed     Abstract available


    March 2020
  61. CROWE A, Henderson MJ, Anderson J, Titus SA, et al
    Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
    J Biol Chem. 2020;295:4001-4013.
    PubMed     Abstract available


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