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  Alzheimer's Disease

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Articles published in J Biol Chem

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    April 2021
  1. VILALTA A, Zhou Y, Sevalle J, Griffin JK, et al
    Wild-type sTREM2 blocks Abeta aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Abeta aggregation.
    J Biol Chem. 2021 Apr 3:100631. doi: 10.1016/j.jbc.2021.100631.
    PubMed     Abstract available


    February 2021
  2. LIU L, Lauro BM, Wolfe MS, Selkoe DJ, et al
    Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate gamma-secretase function in generating Alzheimer-causing Abeta peptides.
    J Biol Chem. 2021 Feb 8:100393. doi: 10.1016/j.jbc.2021.100393.
    PubMed     Abstract available


    January 2021
  3. SOLOVYEV N, El-Khatib AH, Costas-Rodriguez M, Schwab K, et al
    Cu, Fe and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.
    J Biol Chem. 2021 Jan 13:100292. doi: 10.1016/j.jbc.2021.100292.
    PubMed     Abstract available


  4. DEVKOTA S, Williams TD, Wolfe MS
    Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by gamma-secretase to increase amyloid beta-peptides of >45 residues.
    J Biol Chem. 2021 Jan 12:100281. doi: 10.1016/j.jbc.2021.100281.
    PubMed     Abstract available


  5. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2021 Jan 8:100241. doi: 10.1074/jbc.RA120.015327.
    PubMed     Abstract available


    December 2020
  6. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2020 Dec 29. pii: RA120.015327. doi: 10.1074/jbc.RA120.015327.
    PubMed     Abstract available


  7. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020;295:17138-17147.
    PubMed     Abstract available


    November 2020
  8. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020;296:100089.
    PubMed     Abstract available


  9. LEI P, Ayton S, Bush AI
    The Essential Elements of Alzheimer's Disease.
    J Biol Chem. 2020 Nov 20. pii: REV120.008207. doi: 10.1074/jbc.REV120.008207.
    PubMed     Abstract available


  10. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020 Nov 16. pii: RA120.016395. doi: 10.1074/jbc.RA120.016395.
    PubMed     Abstract available


    October 2020
  11. MAULIK M, Vasan L, Bose A, Dutta Chowdhury S, et al
    Amyloid-beta regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes.
    J Biol Chem. 2020;295:15097-15111.
    PubMed     Abstract available


  12. CAO Q, Anderson DH, Liang WY, Chou J, et al
    The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.
    J Biol Chem. 2020;295:14015-14024.
    PubMed     Abstract available


  13. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule Affinity Regulating Kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020 Oct 5. pii: RA120.014420. doi: 10.1074/jbc.RA120.014420.
    PubMed     Abstract available


  14. GU J, Xu W, Jin N, Li L, et al
    Truncation of Tau selectively facilitates its pathological activities.
    J Biol Chem. 2020;295:13812-13828.
    PubMed     Abstract available


    September 2020
  15. MORI T, Koyama N, Yokoo T, Segawa T, et al
    Gallic Acid is a Dual alpha/beta-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
    J Biol Chem. 2020 Sep 10. pii: RA119.012330. doi: 10.1074/jbc.RA119.012330.
    PubMed     Abstract available


  16. KAESER G, Chun J
    Brain cell somatic gene recombination and its phylogenetic foundations.
    J Biol Chem. 2020;295:12786-12795.
    PubMed     Abstract available


    August 2020
  17. SHIMONAKA S, Matsumoto SE, Elahi M, Ishiguro K, et al
    Asparagine residue 368 is involved in Alzheimer's disease tau strain-specific aggregation.
    J Biol Chem. 2020 Aug 5. pii: RA120.013271. doi: 10.1074/jbc.RA120.013271.
    PubMed     Abstract available


    July 2020
  18. KATSIKOUDI A, Ficulle E, Cavallini A, Sharman G, et al
    Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures.
    J Biol Chem. 2020 Jul 22. pii: RA120.013325. doi: 10.1074/jbc.RA120.013325.
    PubMed     Abstract available


  19. GOTOH N, Saito Y, Hata S, Saito H, et al
    Amyloidogenic processing of amyloid beta protein precursor (APP) is enhanced in the brains of alcadein alpha-deficient mice.
    J Biol Chem. 2020;295:9650-9662.
    PubMed     Abstract available


  20. NACHMAN E, Wentink AS, Madiona K, Bousset L, et al
    Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
    J Biol Chem. 2020;295:9676-9690.
    PubMed     Abstract available


  21. CROOKS EJ, Irizarry BA, Ziliox M, Kawakami T, et al
    Copper stabilizes antiparallel beta-sheet fibrils of the amyloid beta40 (Abeta40)-Iowa variant.
    J Biol Chem. 2020;295:8914-8927.
    PubMed     Abstract available


    June 2020
  22. ABSKHARON R, Seidler PM, Sawaya MR, Cascio D, et al
    Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
    J Biol Chem. 2020 Jun 3. pii: RA120.013638. doi: 10.1074/jbc.RA120.013638.
    PubMed     Abstract available


    May 2020
  23. WALLIN C, Jarvet J, Biverstal H, Warmlander S, et al
    Metal ion coordination delays amyloid-beta peptide self-assembly by forming an aggregation-inert complex.
    J Biol Chem. 2020;295:7224-7234.
    PubMed     Abstract available


  24. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42 and high Abeta43.
    J Biol Chem. 2020;295:7442-7451.
    PubMed     Abstract available


  25. SINGH V, Xu L, Boyko S, Surewicz K, et al
    Zinc promotes liquid-liquid phase separation of tau protein.
    J Biol Chem. 2020;295:5850-5856.
    PubMed     Abstract available


    April 2020
  26. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42, high Abeta43.
    J Biol Chem. 2020 Apr 7. pii: RA120.012542. doi: 10.1074/jbc.RA120.012542.
    PubMed     Abstract available


    March 2020
  27. CROWE A, Henderson MJ, Anderson J, Titus SA, et al
    Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
    J Biol Chem. 2020;295:4001-4013.
    PubMed     Abstract available


  28. MURAKAMI K, Obata Y, Sekikawa A, Ueda H, et al
    An RNA aptamer with potent affinity for a toxic dimer of amyloid beta42 has potential utility for histochemical studies of Alzheimer's disease.
    J Biol Chem. 2020 Mar 2. pii: RA119.010955. doi: 10.1074/jbc.RA119.010955.
    PubMed     Abstract available


    January 2020
  29. XIAO Y, Matsuda I, Inoue M, Sasahara T, et al
    NMR-based site-resolved profiling of beta-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.
    J Biol Chem. 2020;295:458-467.
    PubMed     Abstract available


    September 2019
  30. SEIDLER PM, Boyer DR, Murray KA, Yang TP, et al
    Structure-based inhibitors halt prion-like seeding by Alzheimer's disease- and tauopathy-derived brain tissue samples.
    J Biol Chem. 2019 Sep 19. pii: RA119.009688. doi: 10.1074/jbc.RA119.009688.
    PubMed     Abstract available


  31. SCHWEIG JE, Yao H, Coppola K, Jin C, et al
    Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivo.
    J Biol Chem. 2019;294:13378-13395.
    PubMed     Abstract available


    August 2019
  32. TAM SW, Feng R, Lau WK, Law AC, et al
    Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation.
    J Biol Chem. 2019;294:12495-12506.
    PubMed     Abstract available


    July 2019
  33. SHARMA G, Huo A, Kimura T, Shiozawa S, et al
    Tau isoform expression and phosphorylation in marmoset brains.
    J Biol Chem. 2019;294:11433-11444.
    PubMed     Abstract available


  34. LESSARD CB, Rodriguez E, Ladd TB, Minter LM, et al
    Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
    J Biol Chem. 2019;294:11276-11285.
    PubMed     Abstract available


  35. FURUSAWA K, Takasugi T, Chiu YW, Hori Y, et al
    CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.
    J Biol Chem. 2019;294:10886-10899.
    PubMed     Abstract available


    June 2019
  36. LIPPENS G, Gigant B
    Elucidating Tau function and dysfunction in the era of cryo-EM.
    J Biol Chem. 2019;294:9316-9325.
    PubMed     Abstract available


    May 2019
  37. NG J, Kaur H, Collier T, Chang K, et al
    Site-specific glycation of Abeta1-42 affects fibril formation and is neurotoxic.
    J Biol Chem. 2019;294:8806-8818.
    PubMed     Abstract available


  38. BODE DC, Freeley M, Nield J, Palma M, et al
    Amyloid-beta oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy.
    J Biol Chem. 2019;294:7566-7572.
    PubMed     Abstract available


  39. LIU S, Ando F, Fujita Y, Liu J, et al
    A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice.
    J Biol Chem. 2019 May 9. pii: RA118.006420. doi: 10.1074/jbc.RA118.006420.
    PubMed     Abstract available


    April 2019
  40. JAROSZ-GRIFFITHS HH, Corbett NJ, Rowland HA, Fisher K, et al
    Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-beta oligomers.
    J Biol Chem. 2019;294:7085-7097.
    PubMed     Abstract available


    February 2019
  41. MICHNO W, Nystrom S, Wehrli P, Lashley T, et al
    Pyroglutamation of amyloid-betax-42 (Abetax-42) followed by Abeta1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology.
    J Biol Chem. 2019 Feb 27. pii: RA118.006604. doi: 10.1074/jbc.RA118.006604.
    PubMed     Abstract available


  42. SMITH LM, Kostylev MA, Lee S, Strittmatter SM, et al
    Systematic and standardized comparison of reported Amyloid-beta receptors for sufficiency, affinity, and Alzheimer's disease relevance.
    J Biol Chem. 2019 Feb 20. pii: RA118.006252. doi: 10.1074/jbc.RA118.006252.
    PubMed     Abstract available


  43. JEAN L, Brimijoin S, Vaux DJ
    In vivo localization of human acetylcholinesterase-derived species in a beta-sheet conformation at the core of senile plaques in Alzheimer's disease.
    J Biol Chem. 2019 Feb 20. pii: RA118.006230. doi: 10.1074/jbc.RA118.006230.
    PubMed     Abstract available


  44. TANG TC, Kienlen-Campard P, Hu Y, Perrin F, et al
    Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and gamma-secretase processing of the C99 peptide.
    J Biol Chem. 2019 Feb 12. pii: RA118.006061. doi: 10.1074/jbc.RA118.006061.
    PubMed     Abstract available


    January 2019
  45. ANDREW RJ, De Rossi P, Nguyen P, Kowalski HR, et al
    Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model.
    J Biol Chem. 2019 Jan 28. pii: RA118.006379. doi: 10.1074/jbc.RA118.006379.
    PubMed     Abstract available


  46. HUR WS, Mazinani N, Lu XJD, Yefet LS, et al
    Coagulation factor XIIIa cross-links amyloid beta into dimers and oligomers and to blood proteins.
    J Biol Chem. 2019;294:390-396.
    PubMed     Abstract available


    December 2018
  47. MORI T, Koyama N, Tan J, Segawa T, et al
    Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice.
    J Biol Chem. 2018 Dec 18. pii: RA118.004280. doi: 10.1074/jbc.RA118.004280.
    PubMed     Abstract available


    November 2018
  48. WEISMILLER HA, Murphy R, Wei G, Ma B, et al
    Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms.
    J Biol Chem. 2018;293:17336-17348.
    PubMed     Abstract available


    October 2018
  49. SADLEIR KR, Popovic J, Vassar R
    ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.
    J Biol Chem. 2018 Oct 12. pii: RA118.005769. doi: 10.1074/jbc.RA118.005769.
    PubMed     Abstract available


    August 2018
  50. DUNYS J, Valverde A, Checler F
    Are N- and C-terminally Truncated Abeta species key pathological triggers in Alzheimer's disease?
    J Biol Chem. 2018 Aug 24. pii: R118.003999. doi: 10.1074/jbc.R118.003999.
    PubMed     Abstract available


  51. EMENDATO A, Milordini G, Zacco E, Sicorello A, et al
    Glycation affects fibril formation of Abeta peptides.
    J Biol Chem. 2018;293:13100-13111.
    PubMed     Abstract available


  52. DODD RB
    An exTREMe disruption in Alzheimer's cleanup.
    J Biol Chem. 2018;293:12647-12648.
    PubMed     Abstract available


    July 2018
  53. SANKAR SB, Donegan RK, Shah KJ, Reddi AR, et al
    Heme and hemoglobin suppress amyloid beta-mediated inflammatory activation of mouse astrocytes.
    J Biol Chem. 2018;293:11358-11373.
    PubMed     Abstract available


  54. GRIGNASCHI E, Cereghetti G, Grigolato F, Kopp MRG, et al
    A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro.
    J Biol Chem. 2018;293:11424-11432.
    PubMed     Abstract available


    June 2018
  55. YOUNAN ND, Chen KF, Rose RS, Crowther DC, et al
    Prion protein stabilizes amyloid-beta (Abeta) oligomers and enhances Abeta neurotoxicity in a Drosophila model of Alzheimer disease.
    J Biol Chem. 2018 Jun 10. pii: RA118.003319. doi: 10.1074/jbc.RA118.003319.
    PubMed     Abstract available


    May 2018
  56. BISHOF I, Dammer EB, Duong DM, Kundinger S, et al
    RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.
    J Biol Chem. 2018 May 25. pii: RA118.001747. doi: 10.1074/jbc.RA118.001747.
    PubMed     Abstract available


  57. SUDOM A, Talreja S, Danao J, Bragg E, et al
    Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
    J Biol Chem. 2018 May 24. pii: RA118.002352. doi: 10.1074/jbc.RA118.002352.
    PubMed     Abstract available


  58. TAYLOR IR, Ahmad A, Wu T, Nordhues BA, et al
    The disorderly conduct of Hsc70 and its interaction with the Alzheimer's related Tau protein.
    J Biol Chem. 2018 May 15. pii: RA118.002234. doi: 10.1074/jbc.RA118.002234.
    PubMed     Abstract available


  59. BAK LK, Walls AB, Schousboe A, Waagepetersen HS, et al
    Astrocytic glycogen metabolism in the healthy and diseased brain.
    J Biol Chem. 2018;293:7108-7116.
    PubMed     Abstract available


    April 2018
  60. MONDRAGON RODRIGUEZ S, Salas Gallardo A, Gonzalez Pereyra P, Macias M, et al
    Phosphorylation of tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model.
    J Biol Chem. 2018 Apr 9. pii: RA117.001187. doi: 10.1074/jbc.RA117.001187.
    PubMed     Abstract available


    March 2018
  61. CHENG Q, Danao J, Talreja S, Wen P, et al
    TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant TREM2(R47H) on murine myeloid cell function.
    J Biol Chem. 2018 Mar 29. pii: RA118.001848. doi: 10.1074/jbc.RA118.001848.
    PubMed     Abstract available


    January 2018
  62. HASHIMOTO S, Ishii A, Kamano N, Watamura N, et al
    Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm.
    J Biol Chem. 2018 Jan 3. pii: M117.811315. doi: 10.1074/jbc.M117.811315.
    PubMed     Abstract available


    December 2017
  63. GODOY MA, Saraiva LM, Carvalho LRP, Vasconcelos-Dos-Santos A, et al
    Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-beta oligomers.
    J Biol Chem. 2017 Dec 28. pii: M117.807180. doi: 10.1074/jbc.M117.807180.
    PubMed     Abstract available


  64. LAHIRI DK, Maloney B, Greig NH
    Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders.
    J Biol Chem. 2017;292:20353.
    PubMed    


    October 2017
  65. BOVE-FENDERSON E, Urano R, Straub JE, Harris DA, et al
    Cellular prion protein targets amyloid-beta fibril ends via its C-terminal domain to prevent elongation.
    J Biol Chem. 2017;292:16858-16871.
    PubMed     Abstract available


  66. SAADIPOUR K, MacLean M, Pirkle S, Ali S, et al
    The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor.
    J Biol Chem. 2017;292:16594-16604.
    PubMed     Abstract available


    September 2017
  67. CARLOMAGNO Y, Chung DC, Yue M, Castanedes-Casey M, et al
    An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.
    J Biol Chem. 2017;292:15277-15286.
    PubMed     Abstract available


    August 2017
  68. SHMUEL-GALIA L, Klug Y, Porat Z, Charni M, et al
    Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.
    J Biol Chem. 2017;292:13415-13427.
    PubMed     Abstract available


    July 2017
  69. SIDDIQUI SS, Springer SA, Verhagen A, Sundaramurthy V, et al
    The Alzheimer's Disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.
    J Biol Chem. 2017 Jul 26. pii: jbc.M117.799346. doi: 10.1074/jbc.M117.799346.
    PubMed     Abstract available


  70. ZEMPEL H, Dennissen FJA, Kumar Y, Luedtke J, et al
    Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture.
    J Biol Chem. 2017;292:12192-12207.
    PubMed     Abstract available


    June 2017
  71. VARNUM MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, et al
    A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
    J Biol Chem. 2017;292:10651-10663.
    PubMed     Abstract available


  72. PIECHOTTA A, Parthier C, Kleinschmidt M, Gnoth K, et al
    Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
    J Biol Chem. 2017 Jun 16. pii: jbc.M117.777839. doi: 10.1074/jbc.M117.777839.
    PubMed     Abstract available


  73. BUSSIERE R, Lacampagne A, Reiken S, Liu X, et al
    Amyloid beta production is regulated by beta2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.
    J Biol Chem. 2017;292:10153-10168.
    PubMed     Abstract available


    May 2017
  74. HU ZW, Ma MR, Chen YX, Zhao YF, et al
    Phosphorylation at Ser8 as an intrinsic regulatory switch to regulate the morphologies and structures of Alzheimer's 40-residue beta-amyloid (Abeta40) fibrils.
    J Biol Chem. 2017;292:8846.
    PubMed    


  75. YOSHIMURA Y, Holmberg MA, Kukic P, Andersen CB, et al
    MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions.
    J Biol Chem. 2017;292:8269-8278.
    PubMed     Abstract available


  76. MORI T, Koyama N, Tan J, Segawa T, et al
    Combination Therapy with Octyl Gallate and Ferulic Acid Improves Cognition and Neurodegeneration in a Transgenic Mouse Model of Alzheimer Disease.
    J Biol Chem. 2017 May 16. pii: jbc.M116.762658. doi: 10.1074/jbc.M116.762658.
    PubMed     Abstract available


  77. SEIXAS DA SILVA GS, Melo HM, Lourenco MV, Lyra E Silva NM, et al
    Amyloid-beta oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.
    J Biol Chem. 2017;292:7395-7406.
    PubMed     Abstract available


  78. BRITO-MOREIRA J, Lourenco MV, Oliveira MM, Ribeiro FC, et al
    Interaction of amyloid-beta (Abeta) oligomers with neurexin 2alpha and neuroligin 1 mediates synapse damage and memory loss in mice.
    J Biol Chem. 2017;292:7327-7337.
    PubMed     Abstract available


    March 2017
  79. KORSHAVN KJ, Satriano C, Lin Y, Zhang R, et al
    Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-beta.
    J Biol Chem. 2017;292:4638-4650.
    PubMed     Abstract available


  80. GERBER H, Wu F, Dimitrov M, Garcia Osuna GM, et al
    Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by gamma-Secretase and Amyloid-beta Peptide Production.
    J Biol Chem. 2017;292:3751-3767.
    PubMed     Abstract available


    February 2017
  81. MASON AR, Elia LP, Finkbeiner S
    The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels.
    J Biol Chem. 2017;292:3262-3272.
    PubMed     Abstract available


  82. LUO J, Warmlander SK, Graslund A, Abrahams JP, et al
    Cross-interactions between the Alzheimer disease amyloid-beta peptide and other amyloid proteins. A FURTHER ASPECT OF THE AMYLOID CASCADE HYPOTHESIS.
    J Biol Chem. 2017;292:2046.
    PubMed    


  83. FENG T, Tammineni P, Agrawal C, Jeong YY, et al
    Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.
    J Biol Chem. 2017;292:1679-1690.
    PubMed     Abstract available


    January 2017
  84. BODE DC, Baker MD, Viles JH
    Ion Channel Formation by Amyloid-beta42 Oligomers but Not Amyloid-beta40 in Cellular Membranes.
    J Biol Chem. 2017;292:1404-1413.
    PubMed     Abstract available


  85. MERCER SW, Wang J, Burke R
    In vivo Modelling of the Pathogenic Effect of Copper Transporter Mutations that cause Menkes and Wilson Disease, Motor Neuropathy and Susceptibility to Alzheimer's Disease.
    J Biol Chem. 2017 Jan 24. pii: jbc.M116.756163. doi: 10.1074/jbc.M116.756163.
    PubMed     Abstract available


  86. ANO Y, Dhata A, Taniguchi Y, Hoshi A, et al
    Iso-alpha-acids, bitter components of beer, prevent inflammation and cognitive decline induced in a mouse model of Alzheimer's disease.
    J Biol Chem. 2017 Jan 13. pii: jbc.M116.763813. doi: 10.1074/jbc.M116.763813.
    PubMed     Abstract available


  87. HATAMI A, Monjazeb S, Milton S, Glabe CG, et al
    Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide.
    J Biol Chem. 2017 Jan 3. pii: jbc.M116.755264. doi: 10.1074/jbc.M116.755264.
    PubMed     Abstract available


    December 2016
  88. HU ZW, Ma MR, Chen YX, Zhao YF, et al
    Phosphorylation at Ser 8 as an Intrinsic Regulatory Switch to Regulate the Morphologies and Structures of Alzheimer's 40-residue beta-Amyloid (Abeta40) Fibrils.
    J Biol Chem. 2016 Dec 28. pii: jbc.M116.757179. doi: 10.1074/jbc.M116.757179.
    PubMed     Abstract available


    August 2016
  89. DEL PRETE D, Rice RC, Rajadhyaksha AM, D'Adamio L, et al
    Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
    J Biol Chem. 2016;291:17209-27.
    PubMed     Abstract available


    June 2016
  90. POLANCO JC, Scicluna BJ, Hill AF, Gotz J, et al
    Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
    J Biol Chem. 2016;291:12445-66.
    PubMed     Abstract available


  91. DELGADO DA, Doherty K, Cheng Q, Kim H, et al
    Distinct Membrane Disruption Pathways Are Induced by 40-Residue beta-Amyloid Peptides.
    J Biol Chem. 2016;291:12233-44.
    PubMed     Abstract available


  92. CIFELLI JL, Dozier L, Chung TS, Patrick GN, et al
    Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons.
    J Biol Chem. 2016;291:11981-92.
    PubMed     Abstract available


    April 2016
  93. CIVITELLI L, Sandin L, Nelson E, Khattak SI, et al
    The Luminescent Oligothiophene p-FTAA Converts Toxic Abeta1-42 Species into Nontoxic Amyloid Fibers with Altered Properties.
    J Biol Chem. 2016;291:9233-43.
    PubMed     Abstract available


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