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Articles published in J Biol Chem

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    June 2022
  1. ZWIERZCHOWSKI-ZARATE AN, Mendoza-Oliva A, Kashmer OM, Collazo-Lopez JE, et al
    RNA induces unique tau strains and stabilizes Alzheimer's disease seeds.
    J Biol Chem. 2022 Jun 11:102132. doi: 10.1016/j.jbc.2022.102132.
    PubMed     Abstract available

    May 2022
  2. LIANG R, Tian Y, Viles JH
    Cross-seeding of wild-type Amyloid-beta with Arctic but not Italian familial mutants accelerates fibril formation in Alzheimer's Disease.
    J Biol Chem. 2022 May 25:102071. doi: 10.1016/j.jbc.2022.102071.
    PubMed     Abstract available

  3. KOMATSU A, Iida I, Nasu Y, Ito G, et al
    Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum.
    J Biol Chem. 2022;298:101933.
    PubMed     Abstract available

    April 2022
  4. GONZALEZ-GIL A, Porell RN, Fernandes SM, Maenpaa E, et al
    Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease.
    J Biol Chem. 2022 Apr 19:101960. doi: 10.1016/j.jbc.2022.101960.
    PubMed     Abstract available

    March 2022
  5. ZHANG S, Bai P, Lei D, Liang Y, et al
    Degradation and Inhibition of Epigenetic Regulatory Protein BRD4 Exacerbate Alzheimer's Disease-Related Neuropathology in Cell Models.
    J Biol Chem. 2022 Mar 3:101794. doi: 10.1016/j.jbc.2022.101794.
    PubMed     Abstract available

  6. NEDAEI H, Rezaei-Ghaleh N, Giller K, Becker S, et al
    The calcium-free form of atorvastatin inhibits amyloid-beta(1-42) aggregation in vitro.
    J Biol Chem. 2022;298:101662.
    PubMed     Abstract available

    February 2022
  7. PUANGMALAI N, Sengupta U, Bhatt N, Gaikwad S, et al
    Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease.
    J Biol Chem. 2022 Feb 21:101766. doi: 10.1016/j.jbc.2022.101766.
    PubMed     Abstract available

  8. AHMED R, Huang J, Lifshitz R, Martinez Pomier K, et al
    Structural determinants of the interactions of catechins with Abeta oligomers and lipid membranes.
    J Biol Chem. 2022;298:101502.
    PubMed     Abstract available

    January 2022
  9. SHOBO A, James N, Dai D, Rontgen A, et al
    The amyloid-beta1-42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution.
    J Biol Chem. 2022;298:101483.
    PubMed     Abstract available

  10. ACOSTA DM, Mancinelli C, Bracken C, Eliezer D, et al
    Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation.
    J Biol Chem. 2022;298:101442.
    PubMed     Abstract available

    November 2021
  11. IRIZARRY BA, Davis J, Zhu X, Boon BDC, et al
    Human cerebral vascular amyloid contains both antiparallel and parallel in-register Abeta40 fibrils.
    J Biol Chem. 2021;297:101259.
    PubMed     Abstract available

    October 2021
  12. DAI B, Zhong T, Chen ZX, Chen W, et al
    Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
    J Biol Chem. 2021;297:101222.
    PubMed     Abstract available

  13. ISMAEL S, Sindi G, Colvin RA, Lee D, et al
    Activity-dependent release of phosphorylated human tau from Drosophila neurons in primary culture.
    J Biol Chem. 2021;297:101108.
    PubMed     Abstract available

    September 2021
  14. LIU H, Kim C, Haldiman T, Sigurdson CJ, et al
    Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease.
    J Biol Chem. 2021 Sep 29:101267. doi: 10.1016/j.jbc.2021.101267.
    PubMed     Abstract available

  15. NIES SH, Takahashi H, Herber CS, Huttner A, et al
    Spreading of Alzheimer Tau seeds is enhanced by aging and template matching with limited impact of amyloid-beta.
    J Biol Chem. 2021 Sep 1:101159. doi: 10.1016/j.jbc.2021.101159.
    PubMed     Abstract available

  16. YIN T, Yao W, Norris KA, D'Adamio L, et al
    A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission.
    J Biol Chem. 2021;297:101089.
    PubMed     Abstract available

  17. WEISMILLER HA, Holub TJ, Krzesinski BJ, Margittai M, et al
    A thiol-based intramolecular redox switch in four-repeat tau controls fibril assembly and disassembly.
    J Biol Chem. 2021;297:101021.
    PubMed     Abstract available

    August 2021
  18. PERDIGAO C, Barata MA, Burrinha T, Almeida CG, et al
    Alzheimer's disease BIN1 coding variants increase intracellular Abeta levels by interfering with BACE1 recycling.
    J Biol Chem. 2021 Aug 7:101056. doi: 10.1016/j.jbc.2021.101056.
    PubMed     Abstract available

    July 2021
  19. SATO K, Watamura N, Fujioka R, Mihira N, et al
    A 3(rd) generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid beta peptide.
    J Biol Chem. 2021 Jul 27:101004. doi: 10.1016/j.jbc.2021.101004.
    PubMed     Abstract available

  20. VALVERDE A, Dunys J, Lorivel T, Debayle D, et al
    Dipeptidyl peptidase 4 contributes to Alzheimer's disease-like defects in a mouse model and is increased in sporadic Alzheimer's disease brains.
    J Biol Chem. 2021 Jul 12:100963. doi: 10.1016/j.jbc.2021.100963.
    PubMed     Abstract available

  21. KAYED R
    Infectious Etiology and Amyloidosis in Alzheimer's Disease: The Puzzle Continues.
    J Biol Chem. 2021 Jul 1:100936. doi: 10.1016/j.jbc.2021.100936.
    PubMed     Abstract available

    May 2021
  22. BOCHAROVA O, Pandit NP, Molesworth K, Fisher A, et al
    Alzheimer's disease-associated beta-Amyloid does not protect against Herpes Simplex Virus 1 infection in the mouse brain.
    J Biol Chem. 2021 May 27:100845. doi: 10.1016/j.jbc.2021.100845.
    PubMed     Abstract available

    April 2021
  23. VILALTA A, Zhou Y, Sevalle J, Griffin JK, et al
    Wild-type sTREM2 blocks Abeta aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Abeta aggregation.
    J Biol Chem. 2021 Apr 3:100631. doi: 10.1016/j.jbc.2021.100631.
    PubMed     Abstract available

    February 2021
  24. LIU L, Lauro BM, Wolfe MS, Selkoe DJ, et al
    Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate gamma-secretase function in generating Alzheimer-causing Abeta peptides.
    J Biol Chem. 2021 Feb 8:100393. doi: 10.1016/j.jbc.2021.100393.
    PubMed     Abstract available

    January 2021
  25. SOLOVYEV N, El-Khatib AH, Costas-Rodriguez M, Schwab K, et al
    Cu, Fe and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.
    J Biol Chem. 2021 Jan 13:100292. doi: 10.1016/j.jbc.2021.100292.
    PubMed     Abstract available

  26. DEVKOTA S, Williams TD, Wolfe MS
    Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by gamma-secretase to increase amyloid beta-peptides of >45 residues.
    J Biol Chem. 2021 Jan 12:100281. doi: 10.1016/j.jbc.2021.100281.
    PubMed     Abstract available

  27. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2021 Jan 8:100241. doi: 10.1074/jbc.RA120.015327.
    PubMed     Abstract available

  28. CHECLER F, Afram E, Pardossi-Piquard R, Lauritzen I, et al
    Is gamma-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
    J Biol Chem. 2021;296:100489.
    PubMed     Abstract available

  29. SHIELDS LY, Li H, Nguyen K, Kim H, et al
    Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity.
    J Biol Chem. 2021;296:100469.
    PubMed     Abstract available

  30. LEE YH, Im E, Hyun M, Park J, et al
    Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation.
    J Biol Chem. 2021;296:100245.
    PubMed     Abstract available

  31. TALESKI G, Schuhmacher D, Su H, Sontag JM, et al
    Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.
    J Biol Chem. 2021;296:100237.
    PubMed     Abstract available

  32. REYES-RUIZ JM, Nakajima R, Baghallab I, Goldschmidt L, et al
    An "epitomic" analysis of the specificity of conformation-dependent, anti-Ass amyloid monoclonal antibodies.
    J Biol Chem. 2021;296:100168.
    PubMed     Abstract available

  33. ABREHA MH, Ojelade S, Dammer EB, McEachin ZT, et al
    TBK1 interacts with tau and enhances neurodegeneration in tauopathy.
    J Biol Chem. 2021;296:100760.
    PubMed     Abstract available

  34. KONIG AS, Rosener NS, Gremer L, Tusche M, et al
    Structural details of amyloid beta oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy.
    J Biol Chem. 2021;296:100499.
    PubMed     Abstract available

  35. ROBERTS JP, Stokoe SA, Sathler MF, Nichols RA, et al
    Selective coactivation of alpha7- and alpha4beta2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction.
    J Biol Chem. 2021;296:100402.
    PubMed     Abstract available

    December 2020
  36. HE P, Schulz P, Sierks MR
    A conformation specific antibody against Oligomeric beta-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease.
    J Biol Chem. 2020 Dec 29. pii: RA120.015327. doi: 10.1074/jbc.RA120.015327.
    PubMed     Abstract available

  37. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020;295:17138-17147.
    PubMed     Abstract available

    November 2020
  38. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020;296:100089.
    PubMed     Abstract available

  39. LEI P, Ayton S, Bush AI
    The Essential Elements of Alzheimer's Disease.
    J Biol Chem. 2020 Nov 20. pii: REV120.008207. doi: 10.1074/jbc.REV120.008207.
    PubMed     Abstract available

  40. REN S, Breuillaud L, Yao W, Yin T, et al
    TNF-alpha-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2(R47H) rats.
    J Biol Chem. 2020 Nov 16. pii: RA120.016395. doi: 10.1074/jbc.RA120.016395.
    PubMed     Abstract available

    October 2020
  41. MAULIK M, Vasan L, Bose A, Dutta Chowdhury S, et al
    Amyloid-beta regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes.
    J Biol Chem. 2020;295:15097-15111.
    PubMed     Abstract available

  42. CAO Q, Anderson DH, Liang WY, Chou J, et al
    The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.
    J Biol Chem. 2020;295:14015-14024.
    PubMed     Abstract available

  43. OBA T, Saito T, Asada A, Shimizu S, et al
    Microtubule Affinity Regulating Kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    J Biol Chem. 2020 Oct 5. pii: RA120.014420. doi: 10.1074/jbc.RA120.014420.
    PubMed     Abstract available

  44. GU J, Xu W, Jin N, Li L, et al
    Truncation of Tau selectively facilitates its pathological activities.
    J Biol Chem. 2020;295:13812-13828.
    PubMed     Abstract available

    September 2020
  45. MORI T, Koyama N, Yokoo T, Segawa T, et al
    Gallic Acid is a Dual alpha/beta-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
    J Biol Chem. 2020 Sep 10. pii: RA119.012330. doi: 10.1074/jbc.RA119.012330.
    PubMed     Abstract available

  46. KAESER G, Chun J
    Brain cell somatic gene recombination and its phylogenetic foundations.
    J Biol Chem. 2020;295:12786-12795.
    PubMed     Abstract available

    August 2020
  47. SHIMONAKA S, Matsumoto SE, Elahi M, Ishiguro K, et al
    Asparagine residue 368 is involved in Alzheimer's disease tau strain-specific aggregation.
    J Biol Chem. 2020 Aug 5. pii: RA120.013271. doi: 10.1074/jbc.RA120.013271.
    PubMed     Abstract available

    July 2020
  48. KATSIKOUDI A, Ficulle E, Cavallini A, Sharman G, et al
    Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures.
    J Biol Chem. 2020 Jul 22. pii: RA120.013325. doi: 10.1074/jbc.RA120.013325.
    PubMed     Abstract available

  49. GOTOH N, Saito Y, Hata S, Saito H, et al
    Amyloidogenic processing of amyloid beta protein precursor (APP) is enhanced in the brains of alcadein alpha-deficient mice.
    J Biol Chem. 2020;295:9650-9662.
    PubMed     Abstract available

  50. NACHMAN E, Wentink AS, Madiona K, Bousset L, et al
    Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
    J Biol Chem. 2020;295:9676-9690.
    PubMed     Abstract available

  51. CROOKS EJ, Irizarry BA, Ziliox M, Kawakami T, et al
    Copper stabilizes antiparallel beta-sheet fibrils of the amyloid beta40 (Abeta40)-Iowa variant.
    J Biol Chem. 2020;295:8914-8927.
    PubMed     Abstract available

    June 2020
  52. ABSKHARON R, Seidler PM, Sawaya MR, Cascio D, et al
    Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
    J Biol Chem. 2020 Jun 3. pii: RA120.013638. doi: 10.1074/jbc.RA120.013638.
    PubMed     Abstract available

    May 2020
  53. WALLIN C, Jarvet J, Biverstal H, Warmlander S, et al
    Metal ion coordination delays amyloid-beta peptide self-assembly by forming an aggregation-inert complex.
    J Biol Chem. 2020;295:7224-7234.
    PubMed     Abstract available

  54. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42 and high Abeta43.
    J Biol Chem. 2020;295:7442-7451.
    PubMed     Abstract available

  55. SINGH V, Xu L, Boyko S, Surewicz K, et al
    Zinc promotes liquid-liquid phase separation of tau protein.
    J Biol Chem. 2020;295:5850-5856.
    PubMed     Abstract available

    April 2020
  56. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42, high Abeta43.
    J Biol Chem. 2020 Apr 7. pii: RA120.012542. doi: 10.1074/jbc.RA120.012542.
    PubMed     Abstract available

    March 2020
  57. CROWE A, Henderson MJ, Anderson J, Titus SA, et al
    Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
    J Biol Chem. 2020;295:4001-4013.
    PubMed     Abstract available

  58. MURAKAMI K, Obata Y, Sekikawa A, Ueda H, et al
    An RNA aptamer with potent affinity for a toxic dimer of amyloid beta42 has potential utility for histochemical studies of Alzheimer's disease.
    J Biol Chem. 2020 Mar 2. pii: RA119.010955. doi: 10.1074/jbc.RA119.010955.
    PubMed     Abstract available

    January 2020
  59. XIAO Y, Matsuda I, Inoue M, Sasahara T, et al
    NMR-based site-resolved profiling of beta-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.
    J Biol Chem. 2020;295:458-467.
    PubMed     Abstract available

    September 2019
  60. SCHWEIG JE, Yao H, Coppola K, Jin C, et al
    Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivo.
    J Biol Chem. 2019;294:13378-13395.
    PubMed     Abstract available

    August 2019
  61. TAM SW, Feng R, Lau WK, Law AC, et al
    Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation.
    J Biol Chem. 2019;294:12495-12506.
    PubMed     Abstract available

    July 2019
  62. SHARMA G, Huo A, Kimura T, Shiozawa S, et al
    Tau isoform expression and phosphorylation in marmoset brains.
    J Biol Chem. 2019;294:11433-11444.
    PubMed     Abstract available

  63. LESSARD CB, Rodriguez E, Ladd TB, Minter LM, et al
    Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
    J Biol Chem. 2019;294:11276-11285.
    PubMed     Abstract available

  64. FURUSAWA K, Takasugi T, Chiu YW, Hori Y, et al
    CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.
    J Biol Chem. 2019;294:10886-10899.
    PubMed     Abstract available

    June 2019
  65. LIPPENS G, Gigant B
    Elucidating Tau function and dysfunction in the era of cryo-EM.
    J Biol Chem. 2019;294:9316-9325.
    PubMed     Abstract available

    May 2019
  66. NG J, Kaur H, Collier T, Chang K, et al
    Site-specific glycation of Abeta1-42 affects fibril formation and is neurotoxic.
    J Biol Chem. 2019;294:8806-8818.
    PubMed     Abstract available

  67. BODE DC, Freeley M, Nield J, Palma M, et al
    Amyloid-beta oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy.
    J Biol Chem. 2019;294:7566-7572.
    PubMed     Abstract available

    April 2019
  68. JAROSZ-GRIFFITHS HH, Corbett NJ, Rowland HA, Fisher K, et al
    Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-beta oligomers.
    J Biol Chem. 2019;294:7085-7097.
    PubMed     Abstract available

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