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Articles published in J Biol Chem

Retrieve available abstracts of 41 articles:
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Single Articles


    December 2018
  1. MORI T, Koyama N, Tan J, Segawa T, et al
    Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice.
    J Biol Chem. 2018 Dec 18. pii: RA118.004280. doi: 10.1074/jbc.RA118.004280.
    PubMed     Text format     Abstract available


    October 2018
  2. SADLEIR KR, Popovic J, Vassar R
    ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.
    J Biol Chem. 2018 Oct 12. pii: RA118.005769. doi: 10.1074/jbc.RA118.005769.
    PubMed     Text format     Abstract available


    August 2018
  3. DUNYS J, Valverde A, Checler F
    Are N- and C-terminally Truncated Abeta species key pathological triggers in Alzheimer's disease?
    J Biol Chem. 2018 Aug 24. pii: R118.003999. doi: 10.1074/jbc.R118.003999.
    PubMed     Text format     Abstract available


  4. DODD RB
    An exTREMe disruption in Alzheimer's cleanup.
    J Biol Chem. 2018;293:12647-12648.
    PubMed     Text format     Abstract available


    June 2018
  5. YOUNAN ND, Chen KF, Rose RS, Crowther DC, et al
    Prion protein stabilizes amyloid-beta (Abeta) oligomers and enhances Abeta neurotoxicity in a Drosophila model of Alzheimer disease.
    J Biol Chem. 2018 Jun 10. pii: RA118.003319. doi: 10.1074/jbc.RA118.003319.
    PubMed     Text format     Abstract available


    May 2018
  6. BISHOF I, Dammer EB, Duong DM, Kundinger S, et al
    RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.
    J Biol Chem. 2018 May 25. pii: RA118.001747. doi: 10.1074/jbc.RA118.001747.
    PubMed     Text format     Abstract available


  7. SUDOM A, Talreja S, Danao J, Bragg E, et al
    Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
    J Biol Chem. 2018 May 24. pii: RA118.002352. doi: 10.1074/jbc.RA118.002352.
    PubMed     Text format     Abstract available


  8. TAYLOR IR, Ahmad A, Wu T, Nordhues BA, et al
    The disorderly conduct of Hsc70 and its interaction with the Alzheimer's related Tau protein.
    J Biol Chem. 2018 May 15. pii: RA118.002234. doi: 10.1074/jbc.RA118.002234.
    PubMed     Text format     Abstract available


    April 2018
  9. MONDRAGON RODRIGUEZ S, Salas Gallardo A, Gonzalez Pereyra P, Macias M, et al
    Phosphorylation of tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model.
    J Biol Chem. 2018 Apr 9. pii: RA117.001187. doi: 10.1074/jbc.RA117.001187.
    PubMed     Text format     Abstract available


    March 2018
  10. CHENG Q, Danao J, Talreja S, Wen P, et al
    TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant TREM2(R47H) on murine myeloid cell function.
    J Biol Chem. 2018 Mar 29. pii: RA118.001848. doi: 10.1074/jbc.RA118.001848.
    PubMed     Text format     Abstract available


    January 2018
  11. HASHIMOTO S, Ishii A, Kamano N, Watamura N, et al
    Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm.
    J Biol Chem. 2018 Jan 3. pii: M117.811315. doi: 10.1074/jbc.M117.811315.
    PubMed     Text format     Abstract available


    December 2017
  12. LAHIRI DK, Maloney B, Greig NH
    Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders.
    J Biol Chem. 2017;292:20353.
    PubMed     Text format    


    October 2017
  13. BOVE-FENDERSON E, Urano R, Straub JE, Harris DA, et al
    Cellular prion protein targets amyloid-beta fibril ends via its C-terminal domain to prevent elongation.
    J Biol Chem. 2017;292:16858-16871.
    PubMed     Text format     Abstract available


  14. SAADIPOUR K, MacLean M, Pirkle S, Ali S, et al
    The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor.
    J Biol Chem. 2017;292:16594-16604.
    PubMed     Text format     Abstract available


    September 2017
  15. CARLOMAGNO Y, Chung DC, Yue M, Castanedes-Casey M, et al
    An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.
    J Biol Chem. 2017;292:15277-15286.
    PubMed     Text format     Abstract available


    August 2017
  16. SHMUEL-GALIA L, Klug Y, Porat Z, Charni M, et al
    Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.
    J Biol Chem. 2017;292:13415-13427.
    PubMed     Text format     Abstract available


    July 2017
  17. SIDDIQUI SS, Springer SA, Verhagen A, Sundaramurthy V, et al
    The Alzheimer's Disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.
    J Biol Chem. 2017 Jul 26. pii: jbc.M117.799346. doi: 10.1074/jbc.M117.799346.
    PubMed     Text format     Abstract available


  18. ZEMPEL H, Dennissen FJA, Kumar Y, Luedtke J, et al
    Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture.
    J Biol Chem. 2017;292:12192-12207.
    PubMed     Text format     Abstract available


    June 2017
  19. VARNUM MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, et al
    A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
    J Biol Chem. 2017;292:10651-10663.
    PubMed     Text format     Abstract available


  20. PIECHOTTA A, Parthier C, Kleinschmidt M, Gnoth K, et al
    Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
    J Biol Chem. 2017 Jun 16. pii: jbc.M117.777839. doi: 10.1074/jbc.M117.777839.
    PubMed     Text format     Abstract available


  21. BUSSIERE R, Lacampagne A, Reiken S, Liu X, et al
    Amyloid beta production is regulated by beta2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.
    J Biol Chem. 2017;292:10153-10168.
    PubMed     Text format     Abstract available


    May 2017
  22. HU ZW, Ma MR, Chen YX, Zhao YF, et al
    Phosphorylation at Ser8 as an intrinsic regulatory switch to regulate the morphologies and structures of Alzheimer's 40-residue beta-amyloid (Abeta40) fibrils.
    J Biol Chem. 2017;292:8846.
    PubMed     Text format    


  23. YOSHIMURA Y, Holmberg MA, Kukic P, Andersen CB, et al
    MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions.
    J Biol Chem. 2017;292:8269-8278.
    PubMed     Text format     Abstract available


  24. MORI T, Koyama N, Tan J, Segawa T, et al
    Combination Therapy with Octyl Gallate and Ferulic Acid Improves Cognition and Neurodegeneration in a Transgenic Mouse Model of Alzheimer Disease.
    J Biol Chem. 2017 May 16. pii: jbc.M116.762658. doi: 10.1074/jbc.M116.762658.
    PubMed     Text format     Abstract available


  25. SEIXAS DA SILVA GS, Melo HM, Lourenco MV, Lyra E Silva NM, et al
    Amyloid-beta oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.
    J Biol Chem. 2017;292:7395-7406.
    PubMed     Text format     Abstract available


  26. BRITO-MOREIRA J, Lourenco MV, Oliveira MM, Ribeiro FC, et al
    Interaction of amyloid-beta (Abeta) oligomers with neurexin 2alpha and neuroligin 1 mediates synapse damage and memory loss in mice.
    J Biol Chem. 2017;292:7327-7337.
    PubMed     Text format     Abstract available


    March 2017
  27. KORSHAVN KJ, Satriano C, Lin Y, Zhang R, et al
    Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-beta.
    J Biol Chem. 2017;292:4638-4650.
    PubMed     Text format     Abstract available


  28. GERBER H, Wu F, Dimitrov M, Garcia Osuna GM, et al
    Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by gamma-Secretase and Amyloid-beta Peptide Production.
    J Biol Chem. 2017;292:3751-3767.
    PubMed     Text format     Abstract available


    February 2017
  29. MASON AR, Elia LP, Finkbeiner S
    The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels.
    J Biol Chem. 2017;292:3262-3272.
    PubMed     Text format     Abstract available


  30. LUO J, Warmlander SK, Graslund A, Abrahams JP, et al
    Cross-interactions between the Alzheimer disease amyloid-beta peptide and other amyloid proteins. A FURTHER ASPECT OF THE AMYLOID CASCADE HYPOTHESIS.
    J Biol Chem. 2017;292:2046.
    PubMed     Text format    


  31. FENG T, Tammineni P, Agrawal C, Jeong YY, et al
    Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.
    J Biol Chem. 2017;292:1679-1690.
    PubMed     Text format     Abstract available


    January 2017
  32. BODE DC, Baker MD, Viles JH
    Ion Channel Formation by Amyloid-beta42 Oligomers but Not Amyloid-beta40 in Cellular Membranes.
    J Biol Chem. 2017;292:1404-1413.
    PubMed     Text format     Abstract available


  33. MERCER SW, Wang J, Burke R
    In vivo Modelling of the Pathogenic Effect of Copper Transporter Mutations that cause Menkes and Wilson Disease, Motor Neuropathy and Susceptibility to Alzheimer's Disease.
    J Biol Chem. 2017 Jan 24. pii: jbc.M116.756163. doi: 10.1074/jbc.M116.756163.
    PubMed     Text format     Abstract available


  34. ANO Y, Dhata A, Taniguchi Y, Hoshi A, et al
    Iso-alpha-acids, bitter components of beer, prevent inflammation and cognitive decline induced in a mouse model of Alzheimer's disease.
    J Biol Chem. 2017 Jan 13. pii: jbc.M116.763813. doi: 10.1074/jbc.M116.763813.
    PubMed     Text format     Abstract available


  35. HATAMI A, Monjazeb S, Milton S, Glabe CG, et al
    Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide.
    J Biol Chem. 2017 Jan 3. pii: jbc.M116.755264. doi: 10.1074/jbc.M116.755264.
    PubMed     Text format     Abstract available


    December 2016
  36. HU ZW, Ma MR, Chen YX, Zhao YF, et al
    Phosphorylation at Ser 8 as an Intrinsic Regulatory Switch to Regulate the Morphologies and Structures of Alzheimer's 40-residue beta-Amyloid (Abeta40) Fibrils.
    J Biol Chem. 2016 Dec 28. pii: jbc.M116.757179. doi: 10.1074/jbc.M116.757179.
    PubMed     Text format     Abstract available


    August 2016
  37. DEL PRETE D, Rice RC, Rajadhyaksha AM, D'Adamio L, et al
    Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
    J Biol Chem. 2016;291:17209-27.
    PubMed     Text format     Abstract available


    June 2016
  38. POLANCO JC, Scicluna BJ, Hill AF, Gotz J, et al
    Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
    J Biol Chem. 2016;291:12445-66.
    PubMed     Text format     Abstract available


  39. DELGADO DA, Doherty K, Cheng Q, Kim H, et al
    Distinct Membrane Disruption Pathways Are Induced by 40-Residue beta-Amyloid Peptides.
    J Biol Chem. 2016;291:12233-44.
    PubMed     Text format     Abstract available


  40. CIFELLI JL, Dozier L, Chung TS, Patrick GN, et al
    Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons.
    J Biol Chem. 2016;291:11981-92.
    PubMed     Text format     Abstract available


    April 2016
  41. CIVITELLI L, Sandin L, Nelson E, Khattak SI, et al
    The Luminescent Oligothiophene p-FTAA Converts Toxic Abeta1-42 Species into Nontoxic Amyloid Fibers with Altered Properties.
    J Biol Chem. 2016;291:9233-43.
    PubMed     Text format     Abstract available


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