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  Alzheimer's Disease

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Articles published in J Biol Chem

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Single Articles


    June 2020
  1. ABSKHARON R, Seidler PM, Sawaya MR, Cascio D, et al
    Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
    J Biol Chem. 2020 Jun 3. pii: RA120.013638. doi: 10.1074/jbc.RA120.013638.
    PubMed     Abstract available


    April 2020
  2. TAMBINI MD, D'Adamio L
    Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42, high Abeta43.
    J Biol Chem. 2020 Apr 7. pii: RA120.012542. doi: 10.1074/jbc.RA120.012542.
    PubMed     Abstract available


    March 2020
  3. MURAKAMI K, Obata Y, Sekikawa A, Ueda H, et al
    An RNA aptamer with potent affinity for a toxic dimer of amyloid beta42 has potential utility for histochemical studies of Alzheimer's disease.
    J Biol Chem. 2020 Mar 2. pii: RA119.010955. doi: 10.1074/jbc.RA119.010955.
    PubMed     Abstract available


    September 2019
  4. SEIDLER PM, Boyer DR, Murray KA, Yang TP, et al
    Structure-based inhibitors halt prion-like seeding by Alzheimer's disease- and tauopathy-derived brain tissue samples.
    J Biol Chem. 2019 Sep 19. pii: RA119.009688. doi: 10.1074/jbc.RA119.009688.
    PubMed     Abstract available


  5. SCHWEIG JE, Yao H, Coppola K, Jin C, et al
    Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivo.
    J Biol Chem. 2019;294:13378-13395.
    PubMed     Abstract available


    August 2019
  6. TAM SW, Feng R, Lau WK, Law AC, et al
    Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation.
    J Biol Chem. 2019;294:12495-12506.
    PubMed     Abstract available


    July 2019
  7. SHARMA G, Huo A, Kimura T, Shiozawa S, et al
    Tau isoform expression and phosphorylation in marmoset brains.
    J Biol Chem. 2019;294:11433-11444.
    PubMed     Abstract available


  8. LESSARD CB, Rodriguez E, Ladd TB, Minter LM, et al
    Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
    J Biol Chem. 2019;294:11276-11285.
    PubMed     Abstract available


  9. FURUSAWA K, Takasugi T, Chiu YW, Hori Y, et al
    CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.
    J Biol Chem. 2019;294:10886-10899.
    PubMed     Abstract available


    June 2019
  10. LIPPENS G, Gigant B
    Elucidating Tau function and dysfunction in the era of cryo-EM.
    J Biol Chem. 2019;294:9316-9325.
    PubMed     Abstract available


    May 2019
  11. NG J, Kaur H, Collier T, Chang K, et al
    Site-specific glycation of Abeta1-42 affects fibril formation and is neurotoxic.
    J Biol Chem. 2019;294:8806-8818.
    PubMed     Abstract available


  12. BODE DC, Freeley M, Nield J, Palma M, et al
    Amyloid-beta oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy.
    J Biol Chem. 2019;294:7566-7572.
    PubMed     Abstract available


  13. LIU S, Ando F, Fujita Y, Liu J, et al
    A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice.
    J Biol Chem. 2019 May 9. pii: RA118.006420. doi: 10.1074/jbc.RA118.006420.
    PubMed     Abstract available


    April 2019
  14. JAROSZ-GRIFFITHS HH, Corbett NJ, Rowland HA, Fisher K, et al
    Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-beta oligomers.
    J Biol Chem. 2019;294:7085-7097.
    PubMed     Abstract available


    February 2019
  15. MICHNO W, Nystrom S, Wehrli P, Lashley T, et al
    Pyroglutamation of amyloid-betax-42 (Abetax-42) followed by Abeta1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology.
    J Biol Chem. 2019 Feb 27. pii: RA118.006604. doi: 10.1074/jbc.RA118.006604.
    PubMed     Abstract available


  16. SMITH LM, Kostylev MA, Lee S, Strittmatter SM, et al
    Systematic and standardized comparison of reported Amyloid-beta receptors for sufficiency, affinity, and Alzheimer's disease relevance.
    J Biol Chem. 2019 Feb 20. pii: RA118.006252. doi: 10.1074/jbc.RA118.006252.
    PubMed     Abstract available


  17. JEAN L, Brimijoin S, Vaux DJ
    In vivo localization of human acetylcholinesterase-derived species in a beta-sheet conformation at the core of senile plaques in Alzheimer's disease.
    J Biol Chem. 2019 Feb 20. pii: RA118.006230. doi: 10.1074/jbc.RA118.006230.
    PubMed     Abstract available


  18. TANG TC, Kienlen-Campard P, Hu Y, Perrin F, et al
    Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and gamma-secretase processing of the C99 peptide.
    J Biol Chem. 2019 Feb 12. pii: RA118.006061. doi: 10.1074/jbc.RA118.006061.
    PubMed     Abstract available


    January 2019
  19. ANDREW RJ, De Rossi P, Nguyen P, Kowalski HR, et al
    Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model.
    J Biol Chem. 2019 Jan 28. pii: RA118.006379. doi: 10.1074/jbc.RA118.006379.
    PubMed     Abstract available


  20. HUR WS, Mazinani N, Lu XJD, Yefet LS, et al
    Coagulation factor XIIIa cross-links amyloid beta into dimers and oligomers and to blood proteins.
    J Biol Chem. 2019;294:390-396.
    PubMed     Abstract available


    December 2018
  21. MORI T, Koyama N, Tan J, Segawa T, et al
    Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice.
    J Biol Chem. 2018 Dec 18. pii: RA118.004280. doi: 10.1074/jbc.RA118.004280.
    PubMed     Abstract available


    November 2018
  22. WEISMILLER HA, Murphy R, Wei G, Ma B, et al
    Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms.
    J Biol Chem. 2018;293:17336-17348.
    PubMed     Abstract available


    October 2018
  23. SADLEIR KR, Popovic J, Vassar R
    ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.
    J Biol Chem. 2018 Oct 12. pii: RA118.005769. doi: 10.1074/jbc.RA118.005769.
    PubMed     Abstract available


    August 2018
  24. DUNYS J, Valverde A, Checler F
    Are N- and C-terminally Truncated Abeta species key pathological triggers in Alzheimer's disease?
    J Biol Chem. 2018 Aug 24. pii: R118.003999. doi: 10.1074/jbc.R118.003999.
    PubMed     Abstract available


  25. EMENDATO A, Milordini G, Zacco E, Sicorello A, et al
    Glycation affects fibril formation of Abeta peptides.
    J Biol Chem. 2018;293:13100-13111.
    PubMed     Abstract available


  26. DODD RB
    An exTREMe disruption in Alzheimer's cleanup.
    J Biol Chem. 2018;293:12647-12648.
    PubMed     Abstract available


    July 2018
  27. SANKAR SB, Donegan RK, Shah KJ, Reddi AR, et al
    Heme and hemoglobin suppress amyloid beta-mediated inflammatory activation of mouse astrocytes.
    J Biol Chem. 2018;293:11358-11373.
    PubMed     Abstract available


  28. GRIGNASCHI E, Cereghetti G, Grigolato F, Kopp MRG, et al
    A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro.
    J Biol Chem. 2018;293:11424-11432.
    PubMed     Abstract available


    June 2018
  29. YOUNAN ND, Chen KF, Rose RS, Crowther DC, et al
    Prion protein stabilizes amyloid-beta (Abeta) oligomers and enhances Abeta neurotoxicity in a Drosophila model of Alzheimer disease.
    J Biol Chem. 2018 Jun 10. pii: RA118.003319. doi: 10.1074/jbc.RA118.003319.
    PubMed     Abstract available


    May 2018
  30. BISHOF I, Dammer EB, Duong DM, Kundinger S, et al
    RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.
    J Biol Chem. 2018 May 25. pii: RA118.001747. doi: 10.1074/jbc.RA118.001747.
    PubMed     Abstract available


  31. SUDOM A, Talreja S, Danao J, Bragg E, et al
    Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
    J Biol Chem. 2018 May 24. pii: RA118.002352. doi: 10.1074/jbc.RA118.002352.
    PubMed     Abstract available


  32. TAYLOR IR, Ahmad A, Wu T, Nordhues BA, et al
    The disorderly conduct of Hsc70 and its interaction with the Alzheimer's related Tau protein.
    J Biol Chem. 2018 May 15. pii: RA118.002234. doi: 10.1074/jbc.RA118.002234.
    PubMed     Abstract available


  33. BAK LK, Walls AB, Schousboe A, Waagepetersen HS, et al
    Astrocytic glycogen metabolism in the healthy and diseased brain.
    J Biol Chem. 2018;293:7108-7116.
    PubMed     Abstract available


    April 2018
  34. MONDRAGON RODRIGUEZ S, Salas Gallardo A, Gonzalez Pereyra P, Macias M, et al
    Phosphorylation of tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model.
    J Biol Chem. 2018 Apr 9. pii: RA117.001187. doi: 10.1074/jbc.RA117.001187.
    PubMed     Abstract available


    March 2018
  35. CHENG Q, Danao J, Talreja S, Wen P, et al
    TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant TREM2(R47H) on murine myeloid cell function.
    J Biol Chem. 2018 Mar 29. pii: RA118.001848. doi: 10.1074/jbc.RA118.001848.
    PubMed     Abstract available


    January 2018
  36. HASHIMOTO S, Ishii A, Kamano N, Watamura N, et al
    Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm.
    J Biol Chem. 2018 Jan 3. pii: M117.811315. doi: 10.1074/jbc.M117.811315.
    PubMed     Abstract available


    December 2017
  37. GODOY MA, Saraiva LM, Carvalho LRP, Vasconcelos-Dos-Santos A, et al
    Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-beta oligomers.
    J Biol Chem. 2017 Dec 28. pii: M117.807180. doi: 10.1074/jbc.M117.807180.
    PubMed     Abstract available


  38. LAHIRI DK, Maloney B, Greig NH
    Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders.
    J Biol Chem. 2017;292:20353.
    PubMed    


    October 2017
  39. BOVE-FENDERSON E, Urano R, Straub JE, Harris DA, et al
    Cellular prion protein targets amyloid-beta fibril ends via its C-terminal domain to prevent elongation.
    J Biol Chem. 2017;292:16858-16871.
    PubMed     Abstract available


  40. SAADIPOUR K, MacLean M, Pirkle S, Ali S, et al
    The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor.
    J Biol Chem. 2017;292:16594-16604.
    PubMed     Abstract available


    September 2017
  41. CARLOMAGNO Y, Chung DC, Yue M, Castanedes-Casey M, et al
    An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.
    J Biol Chem. 2017;292:15277-15286.
    PubMed     Abstract available


    August 2017
  42. SHMUEL-GALIA L, Klug Y, Porat Z, Charni M, et al
    Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.
    J Biol Chem. 2017;292:13415-13427.
    PubMed     Abstract available


    July 2017
  43. SIDDIQUI SS, Springer SA, Verhagen A, Sundaramurthy V, et al
    The Alzheimer's Disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.
    J Biol Chem. 2017 Jul 26. pii: jbc.M117.799346. doi: 10.1074/jbc.M117.799346.
    PubMed     Abstract available


  44. ZEMPEL H, Dennissen FJA, Kumar Y, Luedtke J, et al
    Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture.
    J Biol Chem. 2017;292:12192-12207.
    PubMed     Abstract available


    June 2017
  45. VARNUM MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, et al
    A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
    J Biol Chem. 2017;292:10651-10663.
    PubMed     Abstract available


  46. PIECHOTTA A, Parthier C, Kleinschmidt M, Gnoth K, et al
    Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
    J Biol Chem. 2017 Jun 16. pii: jbc.M117.777839. doi: 10.1074/jbc.M117.777839.
    PubMed     Abstract available


  47. BUSSIERE R, Lacampagne A, Reiken S, Liu X, et al
    Amyloid beta production is regulated by beta2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.
    J Biol Chem. 2017;292:10153-10168.
    PubMed     Abstract available


    May 2017
  48. HU ZW, Ma MR, Chen YX, Zhao YF, et al
    Phosphorylation at Ser8 as an intrinsic regulatory switch to regulate the morphologies and structures of Alzheimer's 40-residue beta-amyloid (Abeta40) fibrils.
    J Biol Chem. 2017;292:8846.
    PubMed    


  49. YOSHIMURA Y, Holmberg MA, Kukic P, Andersen CB, et al
    MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions.
    J Biol Chem. 2017;292:8269-8278.
    PubMed     Abstract available


  50. MORI T, Koyama N, Tan J, Segawa T, et al
    Combination Therapy with Octyl Gallate and Ferulic Acid Improves Cognition and Neurodegeneration in a Transgenic Mouse Model of Alzheimer Disease.
    J Biol Chem. 2017 May 16. pii: jbc.M116.762658. doi: 10.1074/jbc.M116.762658.
    PubMed     Abstract available


  51. SEIXAS DA SILVA GS, Melo HM, Lourenco MV, Lyra E Silva NM, et al
    Amyloid-beta oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.
    J Biol Chem. 2017;292:7395-7406.
    PubMed     Abstract available


  52. BRITO-MOREIRA J, Lourenco MV, Oliveira MM, Ribeiro FC, et al
    Interaction of amyloid-beta (Abeta) oligomers with neurexin 2alpha and neuroligin 1 mediates synapse damage and memory loss in mice.
    J Biol Chem. 2017;292:7327-7337.
    PubMed     Abstract available


    March 2017
  53. KORSHAVN KJ, Satriano C, Lin Y, Zhang R, et al
    Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-beta.
    J Biol Chem. 2017;292:4638-4650.
    PubMed     Abstract available


  54. GERBER H, Wu F, Dimitrov M, Garcia Osuna GM, et al
    Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by gamma-Secretase and Amyloid-beta Peptide Production.
    J Biol Chem. 2017;292:3751-3767.
    PubMed     Abstract available


    February 2017
  55. MASON AR, Elia LP, Finkbeiner S
    The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels.
    J Biol Chem. 2017;292:3262-3272.
    PubMed     Abstract available


  56. LUO J, Warmlander SK, Graslund A, Abrahams JP, et al
    Cross-interactions between the Alzheimer disease amyloid-beta peptide and other amyloid proteins. A FURTHER ASPECT OF THE AMYLOID CASCADE HYPOTHESIS.
    J Biol Chem. 2017;292:2046.
    PubMed    


  57. FENG T, Tammineni P, Agrawal C, Jeong YY, et al
    Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.
    J Biol Chem. 2017;292:1679-1690.
    PubMed     Abstract available


    January 2017
  58. BODE DC, Baker MD, Viles JH
    Ion Channel Formation by Amyloid-beta42 Oligomers but Not Amyloid-beta40 in Cellular Membranes.
    J Biol Chem. 2017;292:1404-1413.
    PubMed     Abstract available


  59. MERCER SW, Wang J, Burke R
    In vivo Modelling of the Pathogenic Effect of Copper Transporter Mutations that cause Menkes and Wilson Disease, Motor Neuropathy and Susceptibility to Alzheimer's Disease.
    J Biol Chem. 2017 Jan 24. pii: jbc.M116.756163. doi: 10.1074/jbc.M116.756163.
    PubMed     Abstract available


  60. ANO Y, Dhata A, Taniguchi Y, Hoshi A, et al
    Iso-alpha-acids, bitter components of beer, prevent inflammation and cognitive decline induced in a mouse model of Alzheimer's disease.
    J Biol Chem. 2017 Jan 13. pii: jbc.M116.763813. doi: 10.1074/jbc.M116.763813.
    PubMed     Abstract available


  61. HATAMI A, Monjazeb S, Milton S, Glabe CG, et al
    Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide.
    J Biol Chem. 2017 Jan 3. pii: jbc.M116.755264. doi: 10.1074/jbc.M116.755264.
    PubMed     Abstract available


    December 2016
  62. HU ZW, Ma MR, Chen YX, Zhao YF, et al
    Phosphorylation at Ser 8 as an Intrinsic Regulatory Switch to Regulate the Morphologies and Structures of Alzheimer's 40-residue beta-Amyloid (Abeta40) Fibrils.
    J Biol Chem. 2016 Dec 28. pii: jbc.M116.757179. doi: 10.1074/jbc.M116.757179.
    PubMed     Abstract available


    August 2016
  63. DEL PRETE D, Rice RC, Rajadhyaksha AM, D'Adamio L, et al
    Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
    J Biol Chem. 2016;291:17209-27.
    PubMed     Abstract available


    June 2016
  64. POLANCO JC, Scicluna BJ, Hill AF, Gotz J, et al
    Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
    J Biol Chem. 2016;291:12445-66.
    PubMed     Abstract available


  65. DELGADO DA, Doherty K, Cheng Q, Kim H, et al
    Distinct Membrane Disruption Pathways Are Induced by 40-Residue beta-Amyloid Peptides.
    J Biol Chem. 2016;291:12233-44.
    PubMed     Abstract available


  66. CIFELLI JL, Dozier L, Chung TS, Patrick GN, et al
    Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons.
    J Biol Chem. 2016;291:11981-92.
    PubMed     Abstract available


    April 2016
  67. CIVITELLI L, Sandin L, Nelson E, Khattak SI, et al
    The Luminescent Oligothiophene p-FTAA Converts Toxic Abeta1-42 Species into Nontoxic Amyloid Fibers with Altered Properties.
    J Biol Chem. 2016;291:9233-43.
    PubMed     Abstract available


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