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  Alzheimer's Disease

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Articles published in J Neurochem

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    May 2020
  1. DE FREITAS GB, Lourenco MV, De Felice FG
    Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer's disease.
    J Neurochem. 2020 May 12. doi: 10.1111/jnc.15039.
    PubMed     Abstract available


  2. MUNTER LM
    The lipid component of Alzheimer's disease research: An Editorial Highlight for "Brain region-specific amyloid plaque-associated myelin lipid loss, APOE deposition and disruption of the myelin sheath in familial Alzheimer's disease mice" on https://do
    J Neurochem. 2020 May 6. doi: 10.1111/jnc.15025.
    PubMed     Abstract available


    April 2020
  3. FONTANA IC, Zimmer AR, Rocha AS, Gosmann G, et al
    Amyloid-beta oligomers in cellular models of Alzheimer's disease.
    J Neurochem. 2020 Apr 22. doi: 10.1111/jnc.15030.
    PubMed     Abstract available


  4. LI Z, Zhu H, Guo Y, Du X, et al
    Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer's disease.
    J Neurochem. 2020 Apr 22. doi: 10.1111/jnc.15031.
    PubMed     Abstract available


  5. BULLAIN S, Doody R
    What works and what doesn't work in Alzheimer's disease? From interventions on risk factors to anti-amyloid trials.
    J Neurochem. 2020 Apr 11. doi: 10.1111/jnc.15023.
    PubMed     Abstract available


    March 2020
  6. RAJAEI S, Karima S, Sepasi Tehrani H, Shateri S, et al
    Conformational Change and GTPase Activity of Human Tubulin: A Comparative Study on Alzheimer's Disease and Healthy Brain.
    J Neurochem. 2020 Mar 20. doi: 10.1111/jnc.15009.
    PubMed     Abstract available


  7. LI S, Selkoe DJ
    A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Ab oligomers from Alzheimer brain.
    J Neurochem. 2020 Mar 17. doi: 10.1111/jnc.15007.
    PubMed     Abstract available


  8. LI B, Liu J, Gu G, Han X, et al
    Impact of neural stem cell-derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level and synaptic deficits in Alzheimer's disease.
    J Neurochem. 2020 Mar 7. doi: 10.1111/jnc.15001.
    PubMed     Abstract available


  9. KAYA I, Jennische E, Lange S, Baykal AT, et al
    Brain Region Specific Amyloid Plaque Associated Myelin Lipid Loss, APOE Deposition and Disruption of the Myelin Sheath in Familial Alzheimer's Disease Mice.
    J Neurochem. 2020 Mar 5. doi: 10.1111/jnc.14999.
    PubMed     Abstract available


    February 2020
  10. HIERRO-BUJALANCE C, Del Marco A, Ramos-Rodriguez JJ, Infante-Garcia C, et al
    Cell proliferation and neurogenesis alterations in Alzheimer's disease and diabetes mellitus mixed murine models.
    J Neurochem. 2020 Feb 18. doi: 10.1111/jnc.14987.
    PubMed     Abstract available


    January 2020
  11. HOU TY, Zhou Y, Zhu LS, Wang X, et al
    Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease.
    J Neurochem. 2020 Jan 17:e14961. doi: 10.1111/jnc.14961.
    PubMed     Abstract available


    November 2019
  12. IMAMURA O, Arai M, Dateki M, Oishi K, et al
    Donepezil-induced oligodendrocyte differentiation is mediated through estrogen receptors.
    J Neurochem. 2019 Nov 28. doi: 10.1111/jnc.14927.
    PubMed     Abstract available


    October 2019
  13. MICHNO W, Wehrli P, Meier S, Sehlin D, et al
    Chemical Imaging of Evolving Amyloid Plaque Pathology and Associated Abeta Peptide Aggregation in a Transgenic Mouse Model of Alzheimer's Disease.
    J Neurochem. 2019 Oct 12. doi: 10.1111/jnc.14888.
    PubMed     Abstract available


    September 2019
  14. WIJASA TS, Sylvester M, Brocke-Ahmadinejad N, Schwartz S, et al
    Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.
    J Neurochem. 2019 Sep 14. doi: 10.1111/jnc.14870.
    PubMed     Abstract available


    August 2019
  15. ZHU B, Li Z, Qian PY, Herrup K, et al
    Marine bacterial extracts as a new rich source of drugs against Alzheimer's disease.
    J Neurochem. 2019 Aug 5. doi: 10.1111/jnc.14847.
    PubMed     Abstract available


  16. SORGDRAGER FJH, Vermeiren Y, Van Faassen HJR, Van Der Ley CP, et al
    Age- and Disease-Specific Changes of the Kynurenine Pathway in Parkinson's and Alzheimer's Disease.
    J Neurochem. 2019 Aug 3. doi: 10.1111/jnc.14843.
    PubMed     Abstract available


    June 2019
  17. NICHOLS MR, St-Pierre MK, Wendeln AC, Makoni NJ, et al
    Inflammatory mechanisms in neurodegeneration.
    J Neurochem. 2019;149:562-581.
    PubMed     Abstract available


    May 2019
  18. GARCIA-AYLLON MS, Monge-Argiles JA, Monge-Garcia V, Navarrete F, et al
    Measurement of CSF proportional, variant-synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer's disease.
    J Neurochem. 2019 May 11. doi: 10.1111/jnc.14719.
    PubMed     Abstract available


    April 2019
  19. MURAMATSU I, Uwada J, Yoshiki H, Sada K, et al
    Novel regulatory systems for acetylcholine release in rat striatum and anti-Alzheimer's disease drugs.
    J Neurochem. 2019 Apr 10. doi: 10.1111/jnc.14701.
    PubMed     Abstract available


    February 2019
  20. JHA NK, Jha SK, Kar R, Nand P, et al
    Nuclear Factor-Kappa beta as a therapeutic target for Alzheimer's disease.
    J Neurochem. 2019 Feb 25. doi: 10.1111/jnc.14687.
    PubMed     Abstract available


    January 2019
  21. HASCUP ER, Broderick SO, Russell MK, Fang Y, et al
    Diet-induced insulin resistance elevates hippocampal glutamate as well as VGLUT1 and GFAP expression in AbetaPP/PS1 mice.
    J Neurochem. 2019;148:219-237.
    PubMed     Abstract available


    December 2018
  22. CLINE EN, Das A, Bicca MA, Mohammad SN, et al
    A Novel Crosslinking Protocol Stabilizes Amyloid beta Oligomers Capable of Inducing Alzheimer's-Associated Pathologies.
    J Neurochem. 2018 Dec 18. doi: 10.1111/jnc.14647.
    PubMed     Abstract available


    November 2018
  23. CILENTO EM, Jin L, Stewart T, Shi M, et al
    Mass Spectrometry: A Platform for Biomarker Discovery and Validation for Alzheimer's and Parkinson's Diseases.
    J Neurochem. 2018 Nov 26. doi: 10.1111/jnc.14635.
    PubMed     Abstract available


    October 2018
  24. CHANEY A, Williams SR, Boutin H
    In vivo Molecular Imaging of Neuroinflammation in Alzheimer's disease.
    J Neurochem. 2018 Oct 19. doi: 10.1111/jnc.14615.
    PubMed     Abstract available


  25. CISTERNAS P, Zolezzi JM, Martinez M, Torres VI, et al
    Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease.
    J Neurochem. 2018 Oct 9. doi: 10.1111/jnc.14608.
    PubMed     Abstract available


    September 2018
  26. BUTTERFIELD DA, Boyd-Kimball D
    Redox Proteomics and Amyloid beta-Peptide: Insights into Alzheimer Disease.
    J Neurochem. 2018 Sep 14. doi: 10.1111/jnc.14589.
    PubMed     Abstract available


  27. NORRIS CM
    Calcineurin: directing the damage in Alzheimer disease: An Editorial for 'Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain' on doi: 10.1111/jnc.14469.
    J Neurochem. 2018 Sep 7. doi: 10.1111/jnc.14475.
    PubMed     Abstract available


    July 2018
  28. GRANGER MW, Liu H, Fowler CF, Blanchard AP, et al
    Distinct disruptions in Land's cycle remodeling of glycerophosphocholines in murine cortex mark symptomatic onset and progression in two Alzheimer's Disease mouse models.
    J Neurochem. 2018 Jul 24. doi: 10.1111/jnc.14560.
    PubMed     Abstract available


    May 2018
  29. HOPP SC, Bihlmeyer NA, Corradi JP, Vanderburg C, et al
    Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain.
    J Neurochem. 2018 May 28. doi: 10.1111/jnc.14469.
    PubMed     Abstract available


    April 2018
  30. CALVO-FLORES GUZMAN B, Vinnakota C, Govindpani K, Waldvogel H, et al
    The GABAergic System as a Therapeutic Target for Alzheimer's Disease.
    J Neurochem. 2018 Apr 12. doi: 10.1111/jnc.14345.
    PubMed     Abstract available


    March 2018
  31. MARWARHA G, Schommer J, Lund J, Schommer T, et al
    Palmitate-induced C/EBP homologous protein activation leads to NF-kappaB-mediated increase in BACE1 activity and amyloid beta genesis.
    J Neurochem. 2018;144:761-779.
    PubMed     Abstract available


  32. BAZZIGALUPPI P, Beckett TL, Koletar MM, Lai AY, et al
    Early-stage attenuation of phase-amplitude coupling in the hippocampus and medial prefrontal cortex in a transgenic rat model of Alzheimer's disease.
    J Neurochem. 2018;144:669-679.
    PubMed     Abstract available


  33. GORELICK PB
    Prevention of cognitive impairment: scientific guidance and windows of opportunity.
    J Neurochem. 2018;144:609-616.
    PubMed     Abstract available


    February 2018
  34. KWAKOWSKY A, Calvo-Flores Guzman B, Pandya M, Turner C, et al
    GABAA receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus.
    J Neurochem. 2018 Feb 27. doi: 10.1111/jnc.14325.
    PubMed     Abstract available


  35. SAADIPOUR K, Manucat-Tan NB, Lim Y, Keating DJ, et al
    p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.
    J Neurochem. 2018;144:302-317.
    PubMed     Abstract available


    January 2018
  36. GARNER B, Ooi L
    Wnt is here! Could Wnt signalling be promoted to protect against Alzheimer disease?: An Editorial for 'Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20- APP transgenic and wild-type mice' on do
    J Neurochem. 2018 Jan 26. doi: 10.1111/jnc.14276.
    PubMed     Abstract available


  37. PAN Y, Choy KHC, Marriott PJ, Chai SY, et al
    Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets.
    J Neurochem. 2018;144:81-92.
    PubMed     Abstract available


    December 2017
  38. NUCERA A, Hachinski V
    Cerebrovascular and alzheimer disease: fellow travellers or partners in crime?
    J Neurochem. 2017 Dec 21. doi: 10.1111/jnc.14283.
    PubMed     Abstract available


  39. KACZMARCZYK R, Tejera D, Simon BJ, Heneka MT, et al
    Microglia modulation through external vagus nerve stimulation in a murine model of Alzheimer's disease.
    J Neurochem. 2017 Dec 21. doi: 10.1111/jnc.14284.
    PubMed     Abstract available


  40. TAPIA-ROJAS C, Inestrosa NC
    Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice.
    J Neurochem. 2017 Dec 14. doi: 10.1111/jnc.14278.
    PubMed     Abstract available


  41. BRACZYNSKI AK, Schulz JB, Bach JP
    Vaccination strategies in tauopathies and synucleinopathies.
    J Neurochem. 2017;143:467-488.
    PubMed     Abstract available


  42. KAWANO H, Oyabu K, Yamamoto H, Eto K, et al
    Astrocytes with previous chronic exposure to amyloid beta-peptide fragment 1-40 suppress excitatory synaptic transmission.
    J Neurochem. 2017;143:624-634.
    PubMed     Abstract available


  43. COLVIN BA, Rogers VA, Kulas JA, Ridgway EA, et al
    The conformational epitope for a new Abeta42 protofibril-selective antibody partially overlaps with the peptide N-terminal region.
    J Neurochem. 2017;143:736-749.
    PubMed     Abstract available


    November 2017
  44. MOLNAR E
    New tool to tackle Alzheimer's disease: amyloid-beta protofibril-selective antibody AbSL: An Editorial Highlight for 'The conformational epitope for a new Abeta42 protofibril-selective antibody partially overlaps with the peptide N-terminal region' on
    J Neurochem. 2017 Nov 23. doi: 10.1111/jnc.14240.
    PubMed     Abstract available


  45. KUSAKARI S, Nawa M, Sudo K, Matsuoka M, et al
    Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease.
    J Neurochem. 2017 Nov 21. doi: 10.1111/jnc.14258.
    PubMed     Abstract available


  46. NDAY CM, Eleftheriadou D, Jackson G
    Shared Pathological Pathways of Alzheimer's disease with Specific Comorbidities: Current Perspectives and Interventions.
    J Neurochem. 2017 Nov 21. doi: 10.1111/jnc.14256.
    PubMed     Abstract available


  47. CHANEY A, Bauer M, Bochicchio D, Smigova A, et al
    Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe xPS1Deltae9 transgenic mouse model of Alzheimer's disease.
    J Neurochem. 2017 Nov 10. doi: 10.1111/jnc.14251.
    PubMed     Abstract available


    October 2017
  48. BEHL C, Ziegler C
    Beyond Amyloid - Widening the View on Alzheimer's Disease.
    J Neurochem. 2017 Oct 20. doi: 10.1111/jnc.14137.
    PubMed     Abstract available


  49. WILLIAM REBECK G, Pak DTS
    A mobile APP for sharing contacts on your cell: An Editorial Highlight for 'The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system' on page 11.
    J Neurochem. 2017;143:9-10.
    PubMed     Abstract available


  50. SOSA LJ, Caceres A, Dupraz S, Oksdath M, et al
    The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system.
    J Neurochem. 2017;143:11-29.
    PubMed     Abstract available


    August 2017
  51. ROUBROEKS JAY, Smith RG, van den Hove DLA, Lunnon K, et al
    Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases.
    J Neurochem. 2017 Aug 14. doi: 10.1111/jnc.14148.
    PubMed     Abstract available


    July 2017
  52. LAI AY, McLaurin J
    Rho-associated protein kinases as therapeutic targets for both vascular and parenchymal pathologies in Alzheimer's disease.
    J Neurochem. 2017 Jul 19. doi: 10.1111/jnc.14130.
    PubMed     Abstract available


  53. CHENG S, Wani WY, Hottman DA, Jeong A, et al
    Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice.
    J Neurochem. 2017;142:297-304.
    PubMed     Abstract available


  54. NIGAM SM, Xu S, Kritikou JS, Marosi K, et al
    Exercise and BDNF reduce Abeta production by enhancing alpha-secretase processing of APP.
    J Neurochem. 2017;142:286-296.
    PubMed     Abstract available


    May 2017
  55. TSE KH, Herrup K
    Re-imagining Alzheimer's disease - the diminishing importance of amyloid and a glimpse of what lies ahead.
    J Neurochem. 2017 May 26. doi: 10.1111/jnc.14079.
    PubMed     Abstract available


  56. COULSON EJ, Bartlett PF
    An exercise path to preventing Alzheimer's disease: An Editorial Highlight on 'Exercise and BDNF reduce Ab production by enhancing alpha-secretase processing of APP'.
    J Neurochem. 2017 May 18. doi: 10.1111/jnc.14038.
    PubMed     Abstract available


  57. SILMAN I, Sussman JL
    Recent developments in structural studies on acetylcholinesterase.
    J Neurochem. 2017 May 15. doi: 10.1111/jnc.13992.
    PubMed     Abstract available


  58. RODRIGUEZ L, Mohamed NV, Desjardins A, Lippe R, et al
    Rab7A regulates tau secretion.
    J Neurochem. 2017;141:592-605.
    PubMed     Abstract available


    April 2017
  59. ARENDT T, Stieler J, Ueberham U
    Is sporadic Alzheimer's disease a developmental disorder?
    J Neurochem. 2017 Apr 11. doi: 10.1111/jnc.14036.
    PubMed     Abstract available


    March 2017
  60. PUCHOWICZ MA, Seyfried TN
    Novel ketone body therapy for managing Alzheimer's disease: An Editorial Highlight for Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's diseas
    J Neurochem. 2017 Mar 15. doi: 10.1111/jnc.13979.
    PubMed     Abstract available


  61. BRANDT R, Bakota L
    Microtubule dynamics and the neurodegenerative triad of Alzheimer's disease: The hidden connection.
    J Neurochem. 2017 Mar 7. doi: 10.1111/jnc.14011.
    PubMed     Abstract available


    February 2017
  62. GRALLE M
    The neuronal insulin receptor in its environment.
    J Neurochem. 2017;140:359-367.
    PubMed     Abstract available


    January 2017
  63. PAWLOSKY RJ, Kemper MF, Kashiwaya Y, King MT, et al
    Effects of a dietary ketone ester on hippocampal glycolytic and TCA cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease.
    J Neurochem. 2017 Jan 18. doi: 10.1111/jnc.13958.
    PubMed     Abstract available


  64. YAMIN G, Teplow DB
    Pittsburgh Compound-B (PiB) binds amyloid beta-protein protofibrils.
    J Neurochem. 2017;140:210-215.
    PubMed     Abstract available


    December 2016
  65. WHYTE LS, Lau AA, Hemsley KM, Hopwood JJ, et al
    Endo-lysosomal and autophagic dysfunction: A driving factor in Alzheimer's disease?
    J Neurochem. 2016 Dec 27. doi: 10.1111/jnc.13935.
    PubMed     Abstract available


  66. SALMINEN A, Kauppinen A, Kaarniranta K
    Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease.
    J Neurochem. 2016 Dec 17. doi: 10.1111/jnc.13932.
    PubMed     Abstract available


  67. YI B, Sahn JJ, Ardestani PM, Evans AK, et al
    Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuro-inflammation in experimental models of Alzheimer's disease.
    J Neurochem. 2016 Dec 7. doi: 10.1111/jnc.13917.
    PubMed     Abstract available


    November 2016
  68. ELLISON EM, Abner EL, Lovell MA
    Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease.
    J Neurochem. 2016 Nov 27. doi: 10.1111/jnc.13912.
    PubMed     Abstract available


    September 2016
  69. IMAMURA O, Arai M, Dateki M, Takishima K, et al
    Donepezil promotes differentiation of neural stem cells into mature oligodendrocytes at the expense of astrogenesis.
    J Neurochem. 2016 Sep 24. doi: 10.1111/jnc.13856.
    PubMed     Abstract available


  70. MURAMATSU I, Yoshiki H, Uwada J, Masuoka T, et al
    Pharmacological evidence of specific acetylcholine transport in rat cerebral cortex and other brain regions.
    J Neurochem. 2016 Sep 14. doi: 10.1111/jnc.13843.
    PubMed     Abstract available


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