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Articles published in J Neurochem

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Single Articles


    May 2022
  1. QIN YR, Ma CQ, Jiang JH, Wang DP, et al
    Artesunate restores mitochondrial fusion-fission dynamics and alleviates neuronal injury in Alzheimer's disease models.
    J Neurochem. 2022 May 21. doi: 10.1111/jnc.15620.
    PubMed     Abstract available


  2. YU ZY, Yi X, Wang YR, Zeng GH, et al
    Inhibiting alpha1-adrenergic receptor signaling pathway ameliorates AD-type pathologies and behavioral deficits in APPswe/PS1 mouse model.
    J Neurochem. 2022;161:293-307.
    PubMed     Abstract available


  3. LOURENCO MV, Hausmann L
    Editorial: Honouring John Hardy - A true pioneer in research.
    J Neurochem. 2022;161:316-319.
    PubMed     Abstract available


    April 2022
  4. TURATI J, Rudi J, Beauquis J, Carniglia L, et al
    A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model.
    J Neurochem. 2022 Apr 11. doi: 10.1111/jnc.15610.
    PubMed     Abstract available


  5. ZIFF OJ, Ashton NJ, Mehta PR, Brown R, et al
    Amyloid processing in COVID-19-associated neurological syndromes.
    J Neurochem. 2022;161:146-157.
    PubMed     Abstract available


    March 2022
  6. KLAFKI HW, Wirths O, Mollenhauer B, Liepold T, et al
    Detection and quantification of Abeta-3-40 (APP669-711) in cerebrospinal fluid.
    J Neurochem. 2022;160:578-589.
    PubMed     Abstract available


    February 2022
  7. MICHNO W, Wehrli PM, Koutarapu S, Marsching C, et al
    Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging.
    J Neurochem. 2022;160:482-498.
    PubMed     Abstract available


    January 2022
  8. LOPES CR, Amaral IM, Pereira MF, Lopes JP, et al
    Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-beta peptide exposure.
    J Neurochem. 2022 Jan 19. doi: 10.1111/jnc.15575.
    PubMed     Abstract available


    December 2021
  9. KASICA NP, Zhou X, Yang Q, Wang X, et al
    Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer's disease model mice.
    J Neurochem. 2021 Dec 21. doi: 10.1111/jnc.15562.
    PubMed     Abstract available


  10. KUMAR A, Fontana IC, Nordberg A
    Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer's disease.
    J Neurochem. 2021 Dec 20. doi: 10.1111/jnc.15565.
    PubMed     Abstract available


  11. FARUK MO, Tsuboi D, Yamahashi Y, Funahashi Y, et al
    Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning.
    J Neurochem. 2021 Dec 8. doi: 10.1111/jnc.15555.
    PubMed     Abstract available


    November 2021
  12. MA T
    Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer's disease.
    J Neurochem. 2021 Nov 19. doi: 10.1111/jnc.15541.
    PubMed     Abstract available


  13. MATUSZYK MM, Garwood CJ, Ferraiuolo L, Simpson JE, et al
    Biological and Methodological Complexities of Beta-Amyloid Peptide; Implications for Alzheimer's Disease Research.
    J Neurochem. 2021 Nov 12. doi: 10.1111/jnc.15538.
    PubMed     Abstract available


  14. ZULIANI G, Trentini A, Brombo G, Rosta V, et al
    Serum beta-secretase 1 (BACE1) activity increases in patients with mild cognitive impairment.
    J Neurochem. 2021;159:629-637.
    PubMed     Abstract available


    October 2021
  15. HANRIEDER J
    Preface: Mass spectrometry in Alzheimer disease: This is the Preface for the special issue "Mass Spectrometry in Alzheimer Disease".
    J Neurochem. 2021;159:207-210.
    PubMed     Abstract available


  16. GKANATSIOU E, Nilsson J, Toomey CE, Vrillon A, et al
    Amyloid pathology and synaptic loss in pathological aging.
    J Neurochem. 2021;159:258-272.
    PubMed     Abstract available


    September 2021
  17. JAKARIA M, Belaidi AA, Bush AI, Ayton S, et al
    Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease.
    J Neurochem. 2021 Sep 23. doi: 10.1111/jnc.15519.
    PubMed     Abstract available


  18. GEULA C, Dunlop SR, Ayala I, Kawles AS, et al
    Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance.
    J Neurochem. 2021;158:1394-1411.
    PubMed     Abstract available


    July 2021
  19. MICHNO W, Blennow K, Zetterberg H, Brinkmalm G, et al
    Refining the amyloid beta peptide and oligomer fingerprint ambiguities in Alzheimer's disease: mass spectrometric molecular characterization in brain, CSF, blood and plasma.
    J Neurochem. 2021 Jul 10. doi: 10.1111/jnc.15466.
    PubMed     Abstract available


  20. KORECKA M, Shaw LM
    Mass spectrometry-based methods for robust measurement of Alzheimer's Disease biomarkers in biological fluids.
    J Neurochem. 2021 Jul 10. doi: 10.1111/jnc.15465.
    PubMed     Abstract available



  21. Retraction: Clinical trials in Alzheimer's disease': immunotherapy approaches.
    J Neurochem. 2021 Jul 6. doi: 10.1111/jnc.15435.
    PubMed     Abstract available


  22. WANG XM, Zeng P, Fang YY, Zhang T, et al
    Progranulin in neurodegenerative dementia.
    J Neurochem. 2021;158:119-137.
    PubMed     Abstract available


  23. XU L, Tian S, Peng X, Hua Y, et al
    Clusterin inhibits Abeta42 aggregation through a "strawberry model" as detected by FRET-FCS.
    J Neurochem. 2021;158:444-454.
    PubMed     Abstract available


    June 2021
  24. CORTES-GOMEZ MA, Llorens-Alvarez E, Alom J, Del Ser T, et al
    Tau phosphorylation by glycogen synthase kinase 3beta modulates enzyme acetylcholinesterase expression.
    J Neurochem. 2021;157:2091-2105.
    PubMed     Abstract available


    May 2021
  25. LI KY, Xiang XJ, Song L, Chen J, et al
    Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.
    J Neurochem. 2021;157:1351-1365.
    PubMed     Abstract available


    April 2021
  26. LEE-LIU D, Gonzalez-Billault C
    Neuron-intrinsic origin of hyperexcitability during early pathogenesis of Alzheimer's disease: An Editorial Highlight for "Hippocampal hyperactivity in a rat model of Alzheimer's disease" on https://doi.org/10.1111/jnc.15323.
    J Neurochem. 2021 Apr 28. doi: 10.1111/jnc.15248.
    PubMed     Abstract available


  27. SUN L, Bhawal R, Xu H, Chen H, et al
    The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease.
    J Neurochem. 2021 Apr 27. doi: 10.1111/jnc.15377.
    PubMed     Abstract available


  28. VAN DER VELPEN V, Rosenberg N, Maillard V, Teav T, et al
    Sex-specific alterations in NAD+ metabolism in triple transgenic Alzheimer's disease mouse brain assessed by quantitative targeted liquid chromatography - mass spectrometry.
    J Neurochem. 2021 Apr 8. doi: 10.1111/jnc.15362.
    PubMed     Abstract available


    March 2021
  29. BUTLER CA, Thornton P, Brown GC
    CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer's disease-protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion.
    J Neurochem. 2021 Mar 15. doi: 10.1111/jnc.15349.
    PubMed     Abstract available


  30. CHEN H, Cross AC, Thakkar A, Xu H, et al
    Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human-induced pluripotent stem cells, neural stem cells, and neurons.
    J Neurochem. 2021;156:867-879.
    PubMed     Abstract available


    February 2021
  31. SOSULINA L, Mittag M, Geis HR, Hoffmann K, et al
    Hippocampal hyperactivity in a rat model of Alzheimer's disease.
    J Neurochem. 2021 Feb 14. doi: 10.1111/jnc.15323.
    PubMed     Abstract available


  32. ARBER C, Alatza A, Leckey CA, Paterson RW, et al
    Mass spectrometry analysis of tau and amyloid-beta in iPSC-derived models of Alzheimer's disease and dementia.
    J Neurochem. 2021 Feb 4. doi: 10.1111/jnc.15315.
    PubMed     Abstract available


    January 2021
  33. HUANG SJ, Ma YH, Bi YL, Shen XN, et al
    Metabolically healthy obesity and lipids may be protective factors for pathological changes of Alzheimer's disease in cognitively normal adults.
    J Neurochem. 2021 Jan 18. doi: 10.1111/jnc.15306.
    PubMed     Abstract available


  34. GRUNDER G, Cumming P
    Serotonin and amyloid deposition: A link between depression and Alzheimer's disease?: An Editorial Highlight on "Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Abeta production and related pathology in a mouse model of Alzheimer's
    J Neurochem. 2021 Jan 18. doi: 10.1111/jnc.15269.
    PubMed     Abstract available


  35. HARK TJ, Savas JN
    Using stable isotope labeling to advance our understanding of Alzheimer's disease etiology and pathology.
    J Neurochem. 2021 Jan 12. doi: 10.1111/jnc.15298.
    PubMed     Abstract available


    December 2020
  36. HIGHET B, Anekal PV, Ryan B, Murray H, et al
    fISHing with immunohistochemistry for housekeeping gene changes in Alzheimer's disease using an automated quantitative analysis workflow.
    J Neurochem. 2020 Dec 25. doi: 10.1111/jnc.15283.
    PubMed     Abstract available


  37. STOLERO N, Frenkel D
    The Dialog between Neurons and Microglia in Alzheimer's Disease: The Neurotransmitters View.
    J Neurochem. 2020 Dec 12. doi: 10.1111/jnc.15262.
    PubMed     Abstract available


  38. YUEDE CM, Wallace CE, Davis TA, Gardiner WD, et al
    Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Abeta production and related pathology in a mouse model of Alzheimer's disease.
    J Neurochem. 2020 Dec 5. doi: 10.1111/jnc.15260.
    PubMed     Abstract available


  39. GULYAEVA NV
    Hippocampal hyperglutamatergic signaling matters: Early targeting glutamate neurotransmission as a preventive strategy in Alzheimer's disease: An Editorial Highlight for "Riluzole attenuates glutamatergic tone and cognitive decline in AbetaPP/PS1 mice
    J Neurochem. 2020 Dec 4. doi: 10.1111/jnc.15238.
    PubMed     Abstract available


  40. LI W, Wu M, Zhang Y, Wei X, et al
    Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK-3beta in 3xTg-AD mice.
    J Neurochem. 2020;155:697-713.
    PubMed     Abstract available


    November 2020
  41. LI L, Miao M, Chen J, Liu Z, et al
    Role of Tet2 in modulating neuronal morphology and cognition in a mouse model of Alzheimer's disease.
    J Neurochem. 2020 Nov 9. doi: 10.1111/jnc.15234.
    PubMed     Abstract available


  42. VINKLAROVA L, Schmidt M, Benek O, Kuca K, et al
    Friend or enemy? Review of 17beta-HSD10 and its role in human health or disease.
    J Neurochem. 2020;155:231-249.
    PubMed     Abstract available


    October 2020
  43. LIMEGROVER CS, LeVine H 3rd, Izzo NJ, Yurko R, et al
    Alzheimer's Protection Effect of A673T Mutation May Be Driven by Lower Abeta Oligomer Binding Affinity.
    J Neurochem. 2020 Oct 6. doi: 10.1111/jnc.15212.
    PubMed     Abstract available


    September 2020
  44. GAUNITZ S, Tjernberg LO, Schedin-Weiss S
    The N-glycan profile in cortex and hippocampus is altered in Alzheimer s disease.
    J Neurochem. 2020 Sep 28. doi: 10.1111/jnc.15202.
    PubMed     Abstract available


  45. PENA-BAUTISTA C, Alvarez L, Baquero M, Ferrer I, et al
    Plasma isoprostanoids assessment as Alzheimer Disease progression biomarkers.
    J Neurochem. 2020 Sep 12. doi: 10.1111/jnc.15183.
    PubMed     Abstract available


  46. PEREIRA JD, Fraga VG, Santos ALM, das Gracas Carvalho M, et al
    Alzheimer's disease and type 2 diabetes mellitus: a systematic review of proteomic studies.
    J Neurochem. 2020 Sep 9. doi: 10.1111/jnc.15166.
    PubMed     Abstract available


  47. BROSSERON F, Kleemann K, Kolbe CC, Santarelli F, et al
    Interrelations of Alzheimer s disease candidate biomarkers neurogranin, fatty acid binding protein 3 and ferritin to neurodegeneration and neuroinflammation.
    J Neurochem. 2020 Sep 7. doi: 10.1111/jnc.15175.
    PubMed     Abstract available


  48. PEDRINI S, Chatterjee P, Hone E, Martins RN, et al
    High Density Lipoprotein-related cholesterol metabolism in Alzheimer's Disease.
    J Neurochem. 2020 Sep 5. doi: 10.1111/jnc.15170.
    PubMed     Abstract available


    August 2020
  49. WANG L, Liu S, Xu J, Watanabe N, et al
    Emodin inhibits Abeta42 aggregation and improves cognitive deficits in Alzheimer's disease transgenic mice.
    J Neurochem. 2020 Aug 16. doi: 10.1111/jnc.15156.
    PubMed     Abstract available


  50. MOSSER S, Gerber H, Fraering PC
    Identification of truncated C-terminal fragments of the Alzheimer's disease amyloid protein precursor derived from sequential proteolytic pathways.
    J Neurochem. 2020 Aug 5. doi: 10.1111/jnc.15143.
    PubMed     Abstract available


    July 2020
  51. SIMOES-PIRES EN, Ferreira ST, Linden R
    Roles of glutamate receptors in a novel in vitro model of early, comorbid cerebrovascular and Alzheimer's diseases.
    J Neurochem. 2020 Jul 19. doi: 10.1111/jnc.15129.
    PubMed     Abstract available


  52. MARTINS TS, Trindade D, Vaz M, Campelo I, et al
    Diagnostic and therapeutic potential of exosomes in Alzheimer's disease.
    J Neurochem. 2020 Jul 3. doi: 10.1111/jnc.15112.
    PubMed     Abstract available


  53. SATHE G, Albert M, Darrow J, Saito A, et al
    Quantitative proteomic analysis of the frontal cortex in Alzheimer's disease.
    J Neurochem. 2020 Jul 2. doi: 10.1111/jnc.15116.
    PubMed     Abstract available


  54. GUNN AP, Wong BX, McLean C, Fowler C, et al
    Increased glutaminyl cyclase activity in brain of Alzheimer's disease individuals.
    J Neurochem. 2020 Jul 2. doi: 10.1111/jnc.15114.
    PubMed     Abstract available


    May 2020
  55. DE FREITAS GB, Lourenco MV, De Felice FG
    Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer's disease.
    J Neurochem. 2020 May 12. doi: 10.1111/jnc.15039.
    PubMed     Abstract available


  56. MUNTER LM
    The lipid component of Alzheimer's disease research: An Editorial Highlight for "Brain region-specific amyloid plaque-associated myelin lipid loss, APOE deposition and disruption of the myelin sheath in familial Alzheimer's disease mice" on https://do
    J Neurochem. 2020 May 6. doi: 10.1111/jnc.15025.
    PubMed     Abstract available


    April 2020
  57. FONTANA IC, Zimmer AR, Rocha AS, Gosmann G, et al
    Amyloid-beta oligomers in cellular models of Alzheimer's disease.
    J Neurochem. 2020 Apr 22. doi: 10.1111/jnc.15030.
    PubMed     Abstract available


  58. LI Z, Zhu H, Guo Y, Du X, et al
    Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer's disease.
    J Neurochem. 2020 Apr 22. doi: 10.1111/jnc.15031.
    PubMed     Abstract available


  59. BULLAIN S, Doody R
    What works and what doesn't work in Alzheimer's disease? From interventions on risk factors to anti-amyloid trials.
    J Neurochem. 2020 Apr 11. doi: 10.1111/jnc.15023.
    PubMed     Abstract available


    March 2020
  60. RAJAEI S, Karima S, Sepasi Tehrani H, Shateri S, et al
    Conformational Change and GTPase Activity of Human Tubulin: A Comparative Study on Alzheimer's Disease and Healthy Brain.
    J Neurochem. 2020 Mar 20. doi: 10.1111/jnc.15009.
    PubMed     Abstract available


  61. LI S, Selkoe DJ
    A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Ab oligomers from Alzheimer brain.
    J Neurochem. 2020 Mar 17. doi: 10.1111/jnc.15007.
    PubMed     Abstract available


  62. LI B, Liu J, Gu G, Han X, et al
    Impact of neural stem cell-derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level and synaptic deficits in Alzheimer's disease.
    J Neurochem. 2020 Mar 7. doi: 10.1111/jnc.15001.
    PubMed     Abstract available


  63. KAYA I, Jennische E, Lange S, Baykal AT, et al
    Brain Region Specific Amyloid Plaque Associated Myelin Lipid Loss, APOE Deposition and Disruption of the Myelin Sheath in Familial Alzheimer's Disease Mice.
    J Neurochem. 2020 Mar 5. doi: 10.1111/jnc.14999.
    PubMed     Abstract available


    February 2020
  64. HIERRO-BUJALANCE C, Del Marco A, Ramos-Rodriguez JJ, Infante-Garcia C, et al
    Cell proliferation and neurogenesis alterations in Alzheimer's disease and diabetes mellitus mixed murine models.
    J Neurochem. 2020 Feb 18. doi: 10.1111/jnc.14987.
    PubMed     Abstract available


    January 2020
  65. HOU TY, Zhou Y, Zhu LS, Wang X, et al
    Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease.
    J Neurochem. 2020 Jan 17:e14961. doi: 10.1111/jnc.14961.
    PubMed     Abstract available


    November 2019
  66. IMAMURA O, Arai M, Dateki M, Oishi K, et al
    Donepezil-induced oligodendrocyte differentiation is mediated through estrogen receptors.
    J Neurochem. 2019 Nov 28. doi: 10.1111/jnc.14927.
    PubMed     Abstract available


    October 2019
  67. MICHNO W, Wehrli P, Meier S, Sehlin D, et al
    Chemical Imaging of Evolving Amyloid Plaque Pathology and Associated Abeta Peptide Aggregation in a Transgenic Mouse Model of Alzheimer's Disease.
    J Neurochem. 2019 Oct 12. doi: 10.1111/jnc.14888.
    PubMed     Abstract available


    June 2019
  68. NICHOLS MR, St-Pierre MK, Wendeln AC, Makoni NJ, et al
    Inflammatory mechanisms in neurodegeneration.
    J Neurochem. 2019;149:562-581.
    PubMed     Abstract available


    January 2019
  69. HASCUP ER, Broderick SO, Russell MK, Fang Y, et al
    Diet-induced insulin resistance elevates hippocampal glutamate as well as VGLUT1 and GFAP expression in AbetaPP/PS1 mice.
    J Neurochem. 2019;148:219-237.
    PubMed     Abstract available


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