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  Alzheimer's Disease

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Articles published in Nature

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    December 2025
  1. MULLARD A
    How common is Alzheimer's? Blood-test study holds surprises.
    Nature. 2025 Dec 17. doi: 10.1038/d41586-025-04133.
    PubMed    


  2. AARSLAND D, Sunde AL, Tovar-Rios DA, Leuzy A, et al
    Prevalence of Alzheimer's disease pathology in the community.
    Nature. 2025 Dec 17. doi: 10.1038/s41586-025-09841.
    PubMed     Abstract available


  3. AYATA P, Crowley JM, Challman MF, Sahasrabuddhe V, et al
    Lymphoid gene expression supports neuroprotective microglia function.
    Nature. 2025;648:157-165.
    PubMed     Abstract available


  4. CASAMITJANA A, Mancini M, Robinson E, Peter L, et al
    A probabilistic histological atlas of the human brain for MRI segmentation.
    Nature. 2025;648:678-685.
    PubMed     Abstract available


    November 2025
  5. LENHARO M
    Alzheimer's decline slows with just a few thousand steps a day.
    Nature. 2025 Nov 3. doi: 10.1038/d41586-025-03596.
    PubMed    


  6. VON MAYDELL D, Wright SE, Pao PC, Staab C, et al
    ABCA7 variants impact phosphatidylcholine and mitochondria in neurons.
    Nature. 2025;647:462-471.
    PubMed     Abstract available


    October 2025
  7. KAVANAGH K
    Blood tests are now approved for Alzheimer's: how accurate are they?
    Nature. 2025 Oct 17. doi: 10.1038/d41586-025-03394.
    PubMed    


  8. FIELDHOUSE R
    Men's brains shrink faster than women's: what that means for Alzheimer's.
    Nature. 2025 Oct 13. doi: 10.1038/d41586-025-03353.
    PubMed    


    September 2025
  9. KOZLOVA A, Zhang S, Sudwarts A, Zhang H, et al
    PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia.
    Nature. 2025 Sep 3. doi: 10.1038/s41586-025-09486.
    PubMed     Abstract available


  10. GRAVITZ L
    New Hope in Alzheimer's Research.
    Nature. 2025;645:S2.
    PubMed    


  11. HARRISON S
    Can Diet and Exercise Really Prevent Alzheimer's?
    Nature. 2025;645:S3-S5.
    PubMed    


  12. LANDHUIS E
    Alzheimer's Drugs Are Finally Tackling the Disease Itself. Here's How.
    Nature. 2025;645:S6-S9.
    PubMed    


  13. SEEGERT L
    Controversial New Alzheimer's Drugs Offer Hope-But at a High Cost.
    Nature. 2025;645:S10-S12.
    PubMed    


  14. MADHUSOODANAN J
    The Hidden Link between Racism and Alzheimer's Risk.
    Nature. 2025;645:S19-S23.
    PubMed    


  15. WILLYARD C
    The Vexing Promise of New Blood Tests for Alzheimer's.
    Nature. 2025;645:S13-S15.
    PubMed    


    August 2025
  16. SMITH J
    Daily briefing: Lithium supplements reverse Alzheimer's symptoms in mice.
    Nature. 2025 Aug 7. doi: 10.1038/d41586-025-02559.
    PubMed    


  17. PEEPLES L
    New hope for Alzheimer's: lithium supplement reverses memory loss in mice.
    Nature. 2025 Aug 6. doi: 10.1038/d41586-025-02471.
    PubMed    


  18. BUSH AI
    Does lithium deficiency contribute to Alzheimer's disease?
    Nature. 2025 Aug 6. doi: 10.1038/d41586-025-02255.
    PubMed    


  19. ARON L, Ngian ZK, Qiu C, Choi J, et al
    Lithium deficiency and the onset of Alzheimer's disease.
    Nature. 2025 Aug 6. doi: 10.1038/s41586-025-09335.
    PubMed     Abstract available



  20. Human brain organoids reveal new path for Alzheimer's drugs.
    Nature. 2025;644:845.
    PubMed    


    July 2025
  21. MALLAPATY S
    One potent gene raises risk of Alzheimer's, Parkinson's and other brain diseases.
    Nature. 2025 Jul 15. doi: 10.1038/d41586-025-02237.
    PubMed    


  22. HOU K, Ge P, Sawaya MR, Lutter L, et al
    How short peptides disassemble tau fibrils in Alzheimer's disease.
    Nature. 2025 Jul 9. doi: 10.1038/s41586-025-09244.
    PubMed     Abstract available


    April 2025
  23. KIMURA K, Subramanian A, Yin Z, Khalilnezhad A, et al
    Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease.
    Nature. 2025 Apr 9. doi: 10.1038/s41586-025-08852.
    PubMed     Abstract available


  24. MAKIN S
    The future of Alzheimer's treatment.
    Nature. 2025;640:S4-S6.
    PubMed    


  25. DOLGIN E
    Faster, cheaper, better: the rise of blood tests for Alzheimer's.
    Nature. 2025;640:S11-S13.
    PubMed    


  26. HODSON R
    Reframe perspectives on Alzheimer's disease.
    Nature. 2025;640:S1.
    PubMed    


  27. EISENSTEIN M
    Do infections have a role in Alzheimer's disease?
    Nature. 2025;640:S8-S10.
    PubMed    


  28. DREW L
    Alzheimer's disease: highlights from research.
    Nature. 2025;640:S2-S3.
    PubMed    


  29. VARGAS-PARADA L
    The unusual genetic inheritance that could change Alzheimer's treatment.
    Nature. 2025;640:S7.
    PubMed    


  30. BOURZAC K
    Why women experience Alzheimer's disease differently from men.
    Nature. 2025;640:S14-S17.
    PubMed    


    March 2025
  31. GRAHAM F
    Daily briefing: Why women are far more likely to develop Alzheimer's than men.
    Nature. 2025 Mar 25. doi: 10.1038/d41586-025-00956.
    PubMed    


    February 2025
  32. REARDON S
    A man was destined for early Alzheimer's - these genes might explain his escape.
    Nature. 2025 Feb 10. doi: 10.1038/d41586-025-00398.
    PubMed    


    December 2024
  33. KANG K, Seidlitz J, Bethlehem RAI, Xiong J, et al
    Study design features increase replicability in brain-wide association studies.
    Nature. 2024;636:719-727.
    PubMed     Abstract available


    November 2024
  34. KWON D
    New schizophrenia drug could treat Alzheimer's disease.
    Nature. 2024 Nov 21. doi: 10.1038/d41586-024-03707.
    PubMed    


  35. KOZLOV M
    Should Alzheimer's be diagnosed with a blood test? Proposal sparks controversy.
    Nature. 2024 Nov 8. doi: 10.1038/d41586-024-03629.
    PubMed    


    October 2024
  36. DOLGIN E
    Can flashing lights stall Alzheimer's? What the science shows.
    Nature. 2024;634:22-24.
    PubMed    


  37. KOSIK KS
    Francisco Lopera obituary: neurologist who traced genetic origin of early-onset Alzheimer's.
    Nature. 2024;634:537.
    PubMed    


    September 2024
  38. GRAHAM F
    Daily Briefing: Drugs like Ozempic seem to help everything from Alzheimer's to infertility. But how?
    Nature. 2024 Sep 25. doi: 10.1038/d41586-024-03166.
    PubMed    


  39. ZETTERBERG H
    Europe sidelines Alzheimer's drug: lessons must be learnt.
    Nature. 2024;633:255.
    PubMed    


    August 2024
  40. GREEN GS, Fujita M, Yang HS, Taga M, et al
    Cellular communities reveal trajectories of brain ageing and Alzheimer's disease.
    Nature. 2024 Aug 28. doi: 10.1038/s41586-024-07871.
    PubMed     Abstract available


  41. KWON D
    Debate rages over Alzheimer's drug lecanemab as UK limits approval.
    Nature. 2024 Aug 22. doi: 10.1038/d41586-024-02720.
    PubMed    


  42. GRAHAM F
    Daily briefing: Five patterns of brain atrophy associated with ageing and Alzheimer's.
    Nature. 2024 Aug 20. doi: 10.1038/d41586-024-02750.
    PubMed    


  43. NOWOGRODZKI J
    Blood test uses 'protein clock' to predict risk of Alzheimer's and other diseases.
    Nature. 2024 Aug 9. doi: 10.1038/d41586-024-02576.
    PubMed    


  44. ABBOTT A
    Blood tests could soon predict your risk of Alzheimer's.
    Nature. 2024;632:243-245.
    PubMed    


    July 2024
  45. MATHYS H, Boix CA, Akay LA, Xia Z, et al
    Single-cell multiregion dissection of Alzheimer's disease.
    Nature. 2024 Jul 24. doi: 10.1038/s41586-024-07606.
    PubMed     Abstract available


  46. GILBERT MAG, Fatima N, Jenkins J, O'Sullivan TJ, et al
    CryoET of beta-amyloid and tau within postmortem Alzheimer's disease brain.
    Nature. 2024 Jul 10. doi: 10.1038/s41586-024-07680.
    PubMed     Abstract available


  47. SCHERES SHW
    Alzheimer's plaques and tangles revealed by 3D microscopy.
    Nature. 2024 Jul 10. doi: 10.1038/d41586-024-02119.
    PubMed    



  48. AI tool can pinpoint dementia's cause - from stroke to Alzheimer's.
    Nature. 2024 Jul 4. doi: 10.1038/d41586-024-02202.
    PubMed    


    June 2024
  49. REARDON S
    Alzheimer's drug with modest benefits wins backing of FDA advisers.
    Nature. 2024 Jun 10. doi: 10.1038/d41586-024-01726.
    PubMed    


  50. GRAHAM F
    Daily briefing: Landmark Alzheimer's paper will be retracted.
    Nature. 2024 Jun 5. doi: 10.1038/d41586-024-01699.
    PubMed    


    April 2024

  51. A test for Alzheimer's-disease stage predicts dementia risk.
    Nature. 2024;628:11.
    PubMed    


  52. WEN X, Luo Z, Zhao W, Calandrelli R, et al
    Single-cell multiplex chromatin and RNA interactions in ageing human brain.
    Nature. 2024;628:648-656.
    PubMed     Abstract available


    March 2024
  53. HANEY MS, Palovics R, Munson CN, Long C, et al
    APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.
    Nature. 2024 Mar 13. doi: 10.1038/s41586-024-07185.
    PubMed     Abstract available


  54. MURDOCK MH, Yang CY, Sun N, Pao PC, et al
    Multisensory gamma stimulation promotes glymphatic clearance of amyloid.
    Nature. 2024;627:149-156.
    PubMed     Abstract available


  55. LANDHUIS E
    Researchers call for a major rethink of how Alzheimer's treatments are evaluated.
    Nature. 2024;627:S18-S20.
    PubMed    


    February 2024
  56. LENHARO M
    Obesity drugs have another superpower: taming inflammation.
    Nature. 2024;626:246.
    PubMed    


    January 2024
  57. KRAMER K
    Daily briefing: New evidence supports controversial hypothesis of 'transmissible' Alzheimer's.
    Nature. 2024 Jan 30. doi: 10.1038/d41586-024-00282.
    PubMed    


  58. GRAHAM F
    Daily briefing: Drugs such as Ozempic could help with Alzheimer's and Parkinson's.
    Nature. 2024 Jan 29. doi: 10.1038/d41586-024-00272.
    PubMed    


  59. WONG C
    Signs of 'transmissible' Alzheimer's seen in people who received growth hormone.
    Nature. 2024 Jan 29. doi: 10.1038/d41586-024-00268.
    PubMed    


  60. LOVESTAM S, Li D, Wagstaff JL, Kotecha A, et al
    Disease-specific tau filaments assemble via polymorphic intermediates.
    Nature. 2024;625:119-125.
    PubMed     Abstract available


  61. IRVING-PEASE EK, Refoyo-Martinez A, Barrie W, Ingason A, et al
    The selection landscape and genetic legacy of ancient Eurasians.
    Nature. 2024;625:312-320.
    PubMed     Abstract available


    December 2023
  62. THOMPSON T
    How CRISPR gene editing could help treat Alzheimer's.
    Nature. 2023 Dec 11. doi: 10.1038/d41586-023-03931.
    PubMed    


  63. OH HS, Rutledge J, Nachun D, Palovics R, et al
    Organ aging signatures in the plasma proteome track health and disease.
    Nature. 2023;624:164-172.
    PubMed     Abstract available


    November 2023
  64. KOZLOV M
    AI that reads brain scans shows promise for finding Alzheimer's genes.
    Nature. 2023 Nov 10. doi: 10.1038/d41586-023-03482.
    PubMed    


    October 2023
  65. REARDON S
    The brain cells linked to protection against dementia.
    Nature. 2023;622:229-230.
    PubMed    


    September 2023
  66. KRAMER K
    Daily briefing: Alzheimer's makes brain cells undergo 'cellular suicide'.
    Nature. 2023 Sep 19. doi: 10.1038/d41586-023-02965.
    PubMed    


    August 2023
  67. REARDON S
    Alzheimer's drug trials plagued by lack of racial diversity.
    Nature. 2023 Aug 2. doi: 10.1038/d41586-023-02464.
    PubMed    


    July 2023
  68. GRAHAM F
    Daily briefing: Abnormal protein levels could be an early hallmark of Alzheimer's disease.
    Nature. 2023 Jul 24. doi: 10.1038/d41586-023-02418.
    PubMed    


  69. REARDON S
    Alzheimer's drug donanemab helps most when taken at earliest disease stage, study finds.
    Nature. 2023 Jul 17. doi: 10.1038/d41586-023-02321.
    PubMed    


    May 2023
  70. DEPP C, Sun T, Sasmita AO, Spieth L, et al
    Myelin dysfunction drives amyloid-beta deposition in models of Alzheimer's disease.
    Nature. 2023 May 31. doi: 10.1038/s41586-023-06120.
    PubMed     Abstract available


  71. REARDON S
    How one man's rare Alzheimer's mutation delayed the onset of disease.
    Nature. 2023 May 15. doi: 10.1038/d41586-023-01610.
    PubMed    


  72. REARDON S
    Alzheimer's drug donanemab: what promising trial means for treatments.
    Nature. 2023 May 4. doi: 10.1038/d41586-023-01537.
    PubMed    


    April 2023
  73. ABBOTT A, Thompson B
    Audio long read: Conquering Alzheimer's - a look at the therapies of the future.
    Nature. 2023 Apr 28. doi: 10.1038/d41586-023-01351.
    PubMed    


  74. ABBOTT A
    Conquering Alzheimer's: a look at the therapies of the future.
    Nature. 2023;616:26-28.
    PubMed    


    March 2023
  75. GULDNER IH, Wyss-Coray T
    Activated immune cells drive neurodegeneration in an Alzheimer's model.
    Nature. 2023 Mar 8. doi: 10.1038/d41586-023-00600.
    PubMed    


  76. CHEN X, Firulyova M, Manis M, Herz J, et al
    Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.
    Nature. 2023;615:668-677.
    PubMed     Abstract available


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