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Articles published in Int J Cardiol

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Single Articles


    November 2022
  1. ANAGNOSTOPOULOS I, Kousta M, Kossyvakis C, Lakka E, et al
    Weekly physical activity and incident atrial fibrillation in females - A dose-response meta-analysis.
    Int J Cardiol. 2022 Nov 7. pii: S0167-5273(22)01694.
    PubMed     Abstract available


  2. JOLOBE OMP
    Screening for high-grade asymptomatic carotid artery stenosis in nonvalvular atrial fibrillation.
    Int J Cardiol. 2022 Nov 4. pii: S0167-5273(22)01691.
    PubMed    


    October 2022
  3. XING LY, Diederichsen SZ, Hojberg S, Krieger DW, et al
    Screening for atrial fibrillation to prevent stroke in elderly individuals with or without preexisting cardiovascular disease: A post hoc analysis of the randomized LOOP study.
    Int J Cardiol. 2022 Oct 31. pii: S0167-5273(22)01678.
    PubMed     Abstract available


  4. OLIVERI F, Montalto C, Tua L, Lanzillo G, et al
    Direct oral anticoagulants or vitamin K antagonists after TAVR: A systematic review and meta-analysis.
    Int J Cardiol. 2022;365:123-130.
    PubMed     Abstract available


  5. MENG Y, Zhang Y, Zhu C, Nie C, et al
    Atrial high-rate episode burden and stroke risks for patients with device-detected subclinical atrial fibrillation: A systematic review and meta-analysis.
    Int J Cardiol. 2022 Oct 12. pii: S0167-5273(22)01398.
    PubMed     Abstract available


  6. XU W, Lv M, Wu T, Huang N, et al
    Off-label dose direct oral anticoagulants and clinical outcomes in Asian patients with atrial fibrillation: A new evidence of Asian dose.
    Int J Cardiol. 2022 Oct 5. pii: S0167-5273(22)01460.
    PubMed     Abstract available


  7. CASTELLETTI S, Zorzi A, Ballardini E, Basso C, et al
    Molecular genetic testing in athletes: Why and when a position statement from the Italian Society of Sports Cardiology.
    Int J Cardiol. 2022;364:169-177.
    PubMed     Abstract available


  8. ALVES N, Mota M, Cunha M, Ribeiro JM, et al
    Impact of emergent coronary angiography after out-of-the-hospital cardiac arrest without ST-segment elevation - A systematic review and meta-analysis.
    Int J Cardiol. 2022;364:1-8.
    PubMed     Abstract available


    September 2022
  9. LI L, Tu B, Liu S, Zhang Z, et al
    Sex differences in ventricular arrhythmias epidemiology, risk factors, and mortality in congestive heart failure.
    Int J Cardiol. 2022 Sep 28. pii: S0167-5273(22)01415.
    PubMed     Abstract available


  10. SAMMUT MA, Condliffe R, Elliot C, Hameed A, et al
    Atrial flutter and fibrillation in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension in the ASPIRE registry: Comparison of rate versus rhythm control approaches.
    Int J Cardiol. 2022 Sep 18. pii: S0167-5273(22)01341.
    PubMed     Abstract available


  11. LETSAS KP, Saplaouras A
    Atrial fibrillation ablation combined with left atrial appendage occlusion: Optimal patient selection should be the main focus.
    Int J Cardiol. 2022 Sep 9. pii: S0167-5273(22)01323.
    PubMed    


  12. MORI H, Sumitomo N, Tsutsui K, Fukunaga H, et al
    Efficacy of SubcutAneous implantable cardioVErter-defibrillators in
    Int J Cardiol. 2022 Sep 7. pii: S0167-5273(22)01318.
    PubMed    


  13. DONAL E, Sade LE, Kosmala W
    Left atrial deformations: So clinically relevant?
    Int J Cardiol. 2022;362:192-193.
    PubMed    


  14. BRUNS F, Dobrev D
    Assessment of atrial function by echocardiography: Can this be used to assess the arrhythmogenic atrial substrate?
    Int J Cardiol. 2022;362:190-191.
    PubMed    


  15. PERELINI F, Agnew J, Skinner JR, Han DY, et al
    Revisiting QT prolongation in acute rheumatic fever - Relevance for hydroxychloroquine treatment.
    Int J Cardiol. 2022;362:93-96.
    PubMed     Abstract available


  16. BARCELLONA D, Schirru P, Mameli A, Cornacchini S, et al
    Over-anticoagulation by vitamin K antagonists and gender differences.
    Int J Cardiol. 2022;362:147-151.
    PubMed     Abstract available


  17. ALEXOPOULOS D
    In the search of the 'sweet spot' for aspirin discontinuation time in AF patients post PCI.
    Int J Cardiol. 2022;362:55-56.
    PubMed    


  18. PEREIRA MQ, David C, Almeida AG, Brito D, et al
    Clinical effects of off-label reduced doses of Direct Oral Anticoagulants: A systematic review and meta-analysis.
    Int J Cardiol. 2022;362:76-82.
    PubMed     Abstract available


    August 2022
  19. IWAKAWA H, Terata K, Kato R, Kaimori R, et al
    Utility of P-wave abnormalities for distinguishing embolic stroke from non-embolic stroke.
    Int J Cardiol. 2022 Aug 23. pii: S0167-5273(22)01247.
    PubMed     Abstract available


  20. NEDIOS S, Steven D, Sultan A
    Atrioventricular coupling in hypertrophic cardiomyopathy: Partners in crime for new-onset atrial fibrillation.
    Int J Cardiol. 2022 Aug 18. pii: S0167-5273(22)01195.
    PubMed    


  21. HOSSEINI S, Erhart L, Anwer S, Heiniger PS, et al
    Tissue Doppler echocardiography and outcome in arrhythmogenic right ventricular cardiomyopathy.
    Int J Cardiol. 2022 Aug 12. pii: S0167-5273(22)01191.
    PubMed     Abstract available


  22. HERMANS ANL, Gawalko M, Slegers DPJ, Andelfinger N, et al
    Mobile app-based symptom-rhythm correlation assessment in patients with persistent atrial fibrillation.
    Int J Cardiol. 2022 Aug 10. pii: S0167-5273(22)01187.
    PubMed     Abstract available


  23. CHEN M, Sun J, Wang QS, Zhang PP, et al
    Long-term outcome of combined catheter ablation and left atrial appendage closure in atrial fibrillation patients.
    Int J Cardiol. 2022 Aug 8. pii: S0167-5273(22)01174.
    PubMed     Abstract available


  24. BRUNS F, Dobrev D, Fender AC
    Persisting stroke risk in patients with atrial fibrillation despite proper anticoagulation - Unmet clinical needs.
    Int J Cardiol. 2022 Aug 6. pii: S0167-5273(22)01186.
    PubMed    


  25. FISCHLEIN T, Caporali E, Folliguet T, Kappert U, et al
    Randomized controlled trial between conventional versus sutureless bioprostheses for aortic valve replacement: Impact of mini and full sternotomy access at 1-year follow-up.
    Int J Cardiol. 2022 Aug 6. pii: S0167-5273(22)01179.
    PubMed     Abstract available


  26. NIELSEN AB, Skaarup KG, Djernaes K, Biering-Sorensen T, et al
    Reply to left atrial strain: A potential target to predict atrial fibrillation.
    Int J Cardiol. 2022 Aug 4. pii: S0167-5273(22)01170.
    PubMed    


  27. MIGLIORE F, Corrado D
    Implantable defibrillator in patients with inherited arrhythmogenic diseases: Are inapproppriate shocks preventable?
    Int J Cardiol. 2022;360:36-38.
    PubMed    


    July 2022
  28. MOLEK P, Chmiel J, Zabczyk M, Malinowski KP, et al
    Elevated 8-isoprostane concentration is associated with thromboembolic events in patients with atrial fibrillation.
    Int J Cardiol. 2022 Jul 20. pii: S0167-5273(22)01103.
    PubMed     Abstract available


  29. CAI M, Schotten U, Dobrev D, Heijman J, et al
    Atrial fibrillation substrate development before, during and after cardiac surgery: Who is to blame for late post-operative atrial fibrillation?
    Int J Cardiol. 2022 Jul 18. pii: S0167-5273(22)01097.
    PubMed    


  30. TANG ZW, Liu JH, Zhang YX, Mo DG, et al
    Left atrial strain: A potential target to predict atrial fibrillation.
    Int J Cardiol. 2022 Jul 9. pii: S0167-5273(22)01038.
    PubMed    


  31. TAN W, Wang K, Yang X, Wang K, et al
    LncRNA HOTAIR promotes myocardial fibrosis in atrial fibrillation through binding with PTBP1 to increase the stability of Wnt5a.
    Int J Cardiol. 2022 Jul 1. pii: S0167-5273(22)01025.
    PubMed     Abstract available


    June 2022
  32. KORSHOLM K, Valentin JB, Damgaard D, Diener HC, et al
    Clinical outcomes of left atrial appendage occlusion versus direct oral anticoagulation in patients with atrial fibrillation and prior ischemic stroke: A propensity-score matched study.
    Int J Cardiol. 2022 Jun 30. pii: S0167-5273(22)01019.
    PubMed     Abstract available


  33. BAUDO M, D'Ancona G, Trinca F, Rosati F, et al
    Atrioventricular node ablation and pacing for atrial tachyarrhythmias: A meta-analysis of postoperative outcomes.
    Int J Cardiol. 2022 Jun 25. pii: S0167-5273(22)01011.
    PubMed     Abstract available


  34. CHOW KL, O'Donnell JL, Crozier I
    Prevalence, incidence and survival outcomes of cardiac sarcoidosis in the South Island, New Zealand.
    Int J Cardiol. 2022;357:128-133.
    PubMed     Abstract available


  35. QIAN Z, Qin C, Zou F, Xue S, et al
    Complete electrical reverse remodeling of native conduction after resynchronization therapies.
    Int J Cardiol. 2022;357:81-87.
    PubMed     Abstract available


  36. DING YM, Pan YS, Wang MJ, Cao LH, et al
    Factors influencing kinesiophobia during the "blanking period" after radiofrequency catheter ablation in patients with atrial fibrillation by the fear-avoidance model.
    Int J Cardiol. 2022 Jun 15. pii: S0167-5273(22)00920.
    PubMed     Abstract available


  37. MEUCCI MC, Fortuni F, Galloo X, Bootsma M, et al
    Left atrioventricular coupling index in hypertrophic cardiomyopathy and risk of new-onset atrial fibrillation.
    Int J Cardiol. 2022 Jun 15. pii: S0167-5273(22)00916.
    PubMed     Abstract available


  38. VAN SCHIE MS, Veen D, Kharbanda RK, Heida A, et al
    Characterization of pre-existing Arrhythmogenic substrate associated with De novo early and late postoperative atrial fibrillation.
    Int J Cardiol. 2022 Jun 12. pii: S0167-5273(22)00915.
    PubMed     Abstract available


  39. KANY S, Kuck KH, Brachmann J, Andresen D, et al
    Outcomes in patients experiencing complications associated with atrial fibrillation ablation: Data from the German ablation registry.
    Int J Cardiol. 2022 Jun 12. pii: S0167-5273(22)00918.
    PubMed     Abstract available


  40. ZUIN M, Rigatelli G
    Psychological factors as triggers of atrial fibrillation: Seeking for mind-heart connections.
    Int J Cardiol. 2022 Jun 8. pii: S0167-5273(22)00867.
    PubMed    


  41. DECAMPOS D, Teixeira R, Saleiro C, Oliveira-Santos M, et al
    3D printing for left atrial appendage closure: A meta-analysis and systematic review.
    Int J Cardiol. 2022;356:38-43.
    PubMed     Abstract available


  42. RIVOLTA MW, Mainardi LT, Laureanti R, Sassi R, et al
    Association between ventricular repolarization parameters and cardiovascular death in patients of the SWISS-AF cohort.
    Int J Cardiol. 2022;356:53-59.
    PubMed     Abstract available


    May 2022
  43. VAN MOURIK MJW, Arita VA, Lyon A, Lumens J, et al
    Association between comorbidities and left and right atrial dysfunction in patients with paroxysmal atrial fibrillation: Analysis of AF-RISK.
    Int J Cardiol. 2022 May 23. pii: S0167-5273(22)00747.
    PubMed     Abstract available


  44. WU H, Li C, Li B, Zheng T, et al
    Psychological factors and risk of atrial fibrillation: A meta-analysis and systematic review.
    Int J Cardiol. 2022 May 23. pii: S0167-5273(22)00759.
    PubMed     Abstract available


  45. SVARTSTEIN AW, Lassen MH, Skaarup KG, Grove GL, et al
    Predictive value of left atrial strain in relation to atrial fibrillation following acute myocardial infarction.
    Int J Cardiol. 2022 May 13. pii: S0167-5273(22)00736.
    PubMed     Abstract available


  46. CAPPELLETTO C, Stolfo D
    Reply to the Letter to the Editor entitled "The importance of anti-fibrotic drugs as first-line therapy in patients with arrhythmogenic right ventricular dysplasia".
    Int J Cardiol. 2022 May 5. pii: S0167-5273(22)00650.
    PubMed    


  47. STOLFO D, Cappelletto C
    Reply to letter "The effect of beta-blocker on sudden cardiac death in arrhythmogenic right ventricle cardiomyopathy remains to be considered" by Zhenyu Dong et al.
    Int J Cardiol. 2022 May 4. pii: S0167-5273(22)00651.
    PubMed    


  48. PRACON R, Zielinski K, Bangalore S, Konka M, et al
    Residual stroke risk after left atrial appendage closure in patients with prior oral anticoagulation failure.
    Int J Cardiol. 2022;354:17-21.
    PubMed     Abstract available


    April 2022
  49. SADEGHIPOUR P, Farrashi M, De Caterina R
    Response to "non-vitamin K antagonist oral anticoagulants (NOACs) in preventing thromboembolism in atrial fibrillation patients with moderate to severe mitral stenosis: Results from a pilot trial".
    Int J Cardiol. 2022 Apr 29. pii: S0167-5273(22)00637.
    PubMed    


  50. NIELSEN AB, Skaarup KG, Djernaes K, Hauser R, et al
    Left atrial contractile strain predicts recurrence of atrial tachyarrhythmia after catheter ablation.
    Int J Cardiol. 2022 Apr 22. pii: S0167-5273(22)00572.
    PubMed     Abstract available


  51. BERGONTI M, Spera F, Tijskens M, Bonomi A, et al
    A new prediction model for left ventricular systolic function recovery after catheter ablation of atrial fibrillation in patients with heart failure.
    Int J Cardiol. 2022 Apr 17. pii: S0167-5273(22)00554.
    PubMed     Abstract available


  52. DALE Z, Chandrashekar P, Al-Rashdan L, Gill S, et al
    Routine ambulatory heart rhythm monitoring for detection of atrial arrhythmias in transthyretin cardiac amyloidosis.
    Int J Cardiol. 2022 Apr 16. pii: S0167-5273(22)00559.
    PubMed     Abstract available


  53. MAZZONE P, Della Bella P, Baratto F
    Percutaneous left atrial appendage closure vs oral anticoagulation: The scariest might be the cheepest.
    Int J Cardiol. 2022;353:51-52.
    PubMed    


  54. LI L, Dai M, Fu Y
    Non-vitamin K antagonist oral anticoagulants (NOACs) in preventing thromboembolism in atrial fibrillation patients with moderate to severe mitral stenosis: Results from a pilot trial.
    Int J Cardiol. 2022 Apr 10. pii: S0167-5273(22)00508.
    PubMed    


  55. JOLOBE OMP
    Characteristics of the prothrombotic milieu in mitral stenosis patients managed with direct oral anticoagulants.
    Int J Cardiol. 2022 Apr 10. pii: S0167-5273(22)00509.
    PubMed    


  56. JACKSON I, Oyenuga M, Balogun O, Oyenuga A, et al
    Retrospective analyses of factors influencing arrhythmias and the impact of arrhythmias on inpatient outcomes among hospitalized patients with hemochromatosis.
    Int J Cardiol. 2022;352:56-60.
    PubMed     Abstract available


    March 2022
  57. WANG W, Huang Q, Pan D, Zheng W, et al
    The optimal duration of triple antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome or undergoing percutaneous coronary intervention: A network meta-analysis of randomized clinical trials.
    Int J Cardiol. 2022 Mar 29. pii: S0167-5273(22)00441.
    PubMed     Abstract available


  58. SADEGHIPOUR P, Pouraliakbar H, Parsaee M, Shojaeifard M, et al
    RIvaroxaban in mitral stenosis (RISE MS): A pilot randomized clinical trial.
    Int J Cardiol. 2022 Mar 16. pii: S0167-5273(22)00396.
    PubMed     Abstract available


  59. KUO MJ, Lo LW, Lin YJ, Chang SL, et al
    Low voltage zones detected by omnipolar Vmax map accurately identifies the potential atrial substrate and predicts the AF ablation outcome after PV isolation.
    Int J Cardiol. 2022;351:42-47.
    PubMed     Abstract available


  60. GEURTS S, van der Burgh AC, Bos MM, Ikram MA, et al
    Disentangling the association between kidney function and atrial fibrillation: a bidirectional Mendelian randomization study.
    Int J Cardiol. 2022 Mar 9. pii: S0167-5273(22)00323.
    PubMed     Abstract available


    February 2022
  61. LIMONGELLI G, Monda E
    Implantable cardioverter defibrillator in hypertrophic cardiomyopathy: Time to avoid unnecessary procedure.
    Int J Cardiol. 2022 Feb 22. pii: S0167-5273(22)00265.
    PubMed    


  62. CASULA M, Rordorf R
    Concerns about the meta-analysis by Nso et al. comparing subcutaneous and transvenous implantable cardioverter defibrillator.
    Int J Cardiol. 2022 Feb 17. pii: S0167-5273(22)00253.
    PubMed    


  63. ADHADUK M, Paudel B, Liu K, Ashwath M, et al
    The role of electrophysiology study in risk stratification of cardiac sarcoidosis patients: Meta-analyses and systemic review.
    Int J Cardiol. 2022;349:55-61.
    PubMed     Abstract available


  64. FAGA V, Anguera I, Oloriz T, Nombela-Franco L, et al
    Improved prediction of electrical storm in patients with prior myocardial infarction and implantable cardioverter defibrillator.
    Int J Cardiol. 2022 Feb 14. pii: S0167-5273(22)00251.
    PubMed     Abstract available


  65. NEDIOS S, Deneke T
    Anticoagulation after cardioversion of atrial fibrillation: What if we could stop earlier than 4weeks?
    Int J Cardiol. 2022 Feb 7. pii: S0167-5273(22)00200.
    PubMed    


  66. GONZALEZ PEREZ A, Balabanova Y, Saez ME, Brobert G, et al
    Renal decline in patients with non-valvular atrial fibrillation treated with rivaroxaban or warfarin: A population-based study from the United Kingdom.
    Int J Cardiol. 2022 Feb 2. pii: S0167-5273(22)00190.
    PubMed     Abstract available


  67. FENDER AC, Bruns F, Dobrev D
    Minding the gap - Heterogeneity of antithrombotic treatment preferences in complex scenarios in absence of evidence-based guidelines.
    Int J Cardiol. 2022;348:83-84.
    PubMed    


    January 2022
  68. CANPOLAT U
    Mining the P wave to predict recurrence after atrial fibrillation ablation: More than a simple wave!
    Int J Cardiol. 2022 Jan 28. pii: S0167-5273(22)00181.
    PubMed    


  69. AKSIT E, Kucuk U, Taylan G, Cinier G, et al
    The importance of anti-fibrotic drugs as first-line therapy in patients with arrhythmogenic right ventricular dysplasia.
    Int J Cardiol. 2022 Jan 17. pii: S0167-5273(22)00115.
    PubMed    


  70. ADLAM D, Zarebinski M, Uren NG, Ptaszynski P, et al
    A Randomized, double-blind, dose ranging clinical trial of intravenous FDY-5301 in acute STEMI patients undergoing primary PCI.
    Int J Cardiol. 2022;347:1-7.
    PubMed     Abstract available


  71. FUMAGALLI C, De Filippo V, Zocchi C, Tassetti L, et al
    Strength of clinical indication and therapeutic impact of the implantable cardioverter defibrillator in patients with hypertrophic cardiomyopathy.
    Int J Cardiol. 2022 Jan 11. pii: S0167-5273(22)00069.
    PubMed     Abstract available


  72. AURICCHIO A, Sterns LD, Schloss EJ, Gerritse B, et al
    Performance evaluation of implantable cardioverter-defibrillators with SmartShock technology in patients with inherited arrhythmogenic diseases.
    Int J Cardiol. 2022 Jan 6. pii: S0167-5273(22)00007.
    PubMed     Abstract available


  73. OMURO A, Wada Y, Yoshiga Y, Okuda S, et al
    Prevalence and characteristics of transesophageal echocardiography-related esophageal mucosal injury in patients with atrial fibrillation who underwent pulmonary vein isolation.
    Int J Cardiol. 2022 Jan 3. pii: S0167-5273(21)02060.
    PubMed     Abstract available


    December 2021
  74. HUANG CK, Wang JC, Chung CH, Chen SJ, et al
    The risk and timing of acute ischemic stroke after electrical cardioversion for atrial fibrillation in Taiwan: A nationwide population-based cohort study.
    Int J Cardiol. 2021 Dec 23. pii: S0167-5273(21)02038.
    PubMed     Abstract available


  75. MIYAZAKI S, Sekihara T, Hasegawa K, Mukai M, et al
    The feasibility and safety of substrate modification on the left atrial roof area using a cryoballoon in atrial fibrillation ablation.
    Int J Cardiol. 2021 Dec 23. pii: S0167-5273(21)02042.
    PubMed     Abstract available


  76. MIAO Y, Xu M, Yang L, Zhang C, et al
    Investigating the association between P wave duration and atrial fibrillation recurrence after radiofrequency ablation in early persistent atrial fibrillation patients.
    Int J Cardiol. 2021 Dec 23. pii: S0167-5273(21)02039.
    PubMed     Abstract available


  77. LIU W, Bu H
    ECG-based parameters combined exosomes in atrial fibrillation: Diagnosis potential and role as clinical biomarkers.
    Int J Cardiol. 2021 Dec 23. pii: S0167-5273(21)02036.
    PubMed    


  78. KARREGAT EPM, Lucassen WAM, Stoffers HEJH
    Reply to "The role of singlelead ECG in screening for atrial fibrillation deserves more attention".
    Int J Cardiol. 2021 Dec 23. pii: S0167-5273(21)02035.
    PubMed    


  79. D'ANCONA G, Arslan F, Safak E, Weber D, et al
    Actual management costs of patients with non-valvular atrial fibrillation treated with percutaneous left atrial appendage closure or oral anticoagulation.
    Int J Cardiol. 2021 Dec 17. pii: S0167-5273(21)02019.
    PubMed     Abstract available


  80. TAKAYA Y, Nakamura K, Nishii N, Ito H, et al
    Clinical outcomes of patients with isolated cardiac sarcoidosis confirmed by clinical diagnostic criteria.
    Int J Cardiol. 2021;345:49-53.
    PubMed     Abstract available


  81. DI LULLO L, Lavalle C, Magnocavallo M, Mariani MV, et al
    New evidence of direct oral anticoagulation therapy on cardiac valve calcifications, renal preservation and inflammatory modulation.
    Int J Cardiol. 2021;345:90-97.
    PubMed     Abstract available


  82. ALPERI A, Pascual I, Avanzas P, Moris C, et al
    Atrial-FMR: No longer the forgotten mechanism of functional mitral regurgitation.
    Int J Cardiol. 2021 Dec 14. pii: S0167-5273(21)01999.
    PubMed    


  83. LEMESLE G, Bauters C, Bonello L, Fauchier L, et al
    Management of antithrombotics in situations with a gap in evidence: A national French survey focusing on patients with coronary artery disease and atrial fibrillation.
    Int J Cardiol. 2021 Dec 2. pii: S0167-5273(21)01966.
    PubMed     Abstract available


  84. D'ANCONA G, Ince H
    Rehospitalization and actual management costs after percutaneous left atrial appendage closure: Facing the conundrum.
    Int J Cardiol. 2021;344:84-85.
    PubMed    


    November 2021
  85. DONG Z, Yusup M, Lu Y, Tang B, et al
    The role of singlelead ECG in screening for atrial fibrillation deserves more attention.
    Int J Cardiol. 2021 Nov 29. pii: S0167-5273(21)01962.
    PubMed    


  86. DALE Z, Al-Rashdan L, Elman M, Chandrashekar P, et al
    Mode of death and outcomes of implantable cardioverter defibrillators in transthyretin amyloid cardiomyopathy.
    Int J Cardiol. 2021 Nov 26. pii: S0167-5273(21)01874.
    PubMed     Abstract available


  87. PIOT O, Defaye P, Lortet-Tieulent J, Deharo JC, et al
    Healthcare costs in implantable cardioverter-defibrillator recipients: A real-life cohort study on 19,408 patients from the French national healthcare database.
    Int J Cardiol. 2021 Nov 26. pii: S0167-5273(21)01872.
    PubMed     Abstract available


  88. YANG H, Wang Y, Ji Q
    Author's reply to the Letter to the Editor from Dr. Jun Yang: THBS1: A potential biomarker for atrial fibrillation.
    Int J Cardiol. 2021 Nov 24. pii: S0167-5273(21)01868.
    PubMed    


  89. NSO N, Nassar M, Lakhdar S, Enoru S, et al
    Comparative assessment of transvenous versus subcutaneous implantable cardioverter-defibrillator therapy outcomes: An updated systematic review and meta-analysis.
    Int J Cardiol. 2021 Nov 18. pii: S0167-5273(21)01846.
    PubMed     Abstract available


  90. SVENNBERG E, Engdahl J
    Screening for atrial fibrillation: If I was left to my own devices.
    Int J Cardiol. 2021 Nov 16. pii: S0167-5273(21)01847.
    PubMed    


  91. YUSUP M, Dong Z, Lu Y, Tang B, et al
    When using the left atrial appendage occlusion device, atrial fibrillation itself should not be ignored.
    Int J Cardiol. 2021 Nov 16. pii: S0167-5273(21)01840.
    PubMed    


  92. RAHMAN MU, Amritphale A, Kumar S, Trice C, et al
    Assessment of independent clinical predictors of early readmission after percutaneous endoluminal left atrial appendage closure with the Watchman device using National Readmission Database.
    Int J Cardiol. 2021;343:21-26.
    PubMed     Abstract available


  93. MARSTON XL, Wang R, Yeh YC, Zimmermann L, et al
    Comparison of clinical outcomes of edoxaban versus apixaban, dabigatran, rivaroxaban, and vitamin K antagonists in patients with atrial fibrillation in Germany: A real-world cohort study.
    Int J Cardiol. 2021 Nov 12. pii: S0167-5273(21)01776.
    PubMed     Abstract available


  94. ZHENG X, Wang F, Zhang J, Cui X, et al
    Using machine learning to predict atrial fibrillation diagnosed after ischemic stroke.
    Int J Cardiol. 2021 Nov 11. pii: S0167-5273(21)01773.
    PubMed     Abstract available


  95. TEMPORELLI PL, Arbelo E, Laroche C, Blomstrom-Lundqvist C, et al
    Atrial fibrillation ablation in heart failure: Findings from the ESC-EHRA EORP Atrial Fibrillation Ablation long-term (AFA LT) registry.
    Int J Cardiol. 2021 Nov 11. pii: S0167-5273(21)01779.
    PubMed     Abstract available


  96. MANNINA C, Di Tullio MR
    Screening for atrial fibrillation in the elderly.
    Int J Cardiol. 2021 Nov 2. pii: S0167-5273(21)01760.
    PubMed    


  97. UDANI K, Chris-Olaiya A, Ohadugha C, Malik A, et al
    Cardiovascular manifestations in hospitalized patients with hemochromatosis in the United States.
    Int J Cardiol. 2021;342:117-124.
    PubMed     Abstract available


  98. YANO M, Egami Y, Ukita K, Yasumoto K, et al
    Reply to "Inflammatory markers might be used to predict early arrhythmia recurrence after atrial fibrillation ablation".
    Int J Cardiol. 2021 Nov 1. pii: S0167-5273(21)01759.
    PubMed    


    October 2021
  99. LIU H, Yang J, Zhang J, Zheng T, et al
    THBS1: a potential biomarker for atrial fibrillation.
    Int J Cardiol. 2021 Oct 29. pii: S0167-5273(21)01764.
    PubMed    


  100. SONG J, Dobrev D, Li N
    Proteomics: A promising approach to discover new biomarkers for atrial fibrillation.
    Int J Cardiol. 2021 Oct 25. pii: S0167-5273(21)01689.
    PubMed    


  101. KARREGAT EPM, Gurp NV, Bouwman AC, Uittenbogaart SB, et al
    Screening for paroxysmal atrial fibrillation in primary care using Holter monitoring and intermittent, ambulatory single-lead electrocardiography.
    Int J Cardiol. 2021 Oct 20. pii: S0167-5273(21)01575.
    PubMed     Abstract available


  102. DONG Z, Lu Y, Tang B
    The effect of Beta-blocker on sudden cardiac death in arrhythmogenic right ventricle cardiomyopathy remains to be considered.
    Int J Cardiol. 2021 Oct 4. pii: S0167-5273(21)01502.
    PubMed    


    September 2021
  103. RADINOVIC A, Falasconi G, Marzi A, D'Angelo G, et al
    Long-term outcome of left atrial appendage occlusion with multiple devices.
    Int J Cardiol. 2021 Sep 29. pii: S0167-5273(21)01492.
    PubMed     Abstract available


  104. ZHONG W, Yang H, Wang Y, Yang Y, et al
    Proteomic profiles of patients with atrial fibrillation provide candidate biomarkers for diagnosis.
    Int J Cardiol. 2021 Sep 27. pii: S0167-5273(21)01489.
    PubMed     Abstract available


  105. SHANG L, Sun H, Tang B
    Screening for atrial fibrillation in older populations: Outcome is more important than detection.
    Int J Cardiol. 2021 Sep 25. pii: S0167-5273(21)01486.
    PubMed    


  106. MO D, Xin F, Su J
    Inflammatory markers might be used to predict early arrhythmia recurrence after atrial fibrillation ablation.
    Int J Cardiol. 2021 Sep 25. pii: S0167-5273(21)01485.
    PubMed    


  107. MULDER MJ, Kemme MJB, Hopman LHGA, Kusgozoglu E, et al
    Comparison of the predictive value of ten risk scores for outcomes of atrial fibrillation patients undergoing radiofrequency pulmonary vein isolation.
    Int J Cardiol. 2021 Sep 20. pii: S0167-5273(21)01468.
    PubMed     Abstract available


  108. BARISON A, Aimo A
    Digoxin use in patients with cardiovascular diseases: An old remedy for future medicine?
    Int J Cardiol. 2021;339:106-107.
    PubMed    


  109. KAYVANPOUR E, Sammani A, Sedaghat-Hamedani F, Lehmann DH, et al
    A novel risk model for predicting potentially life-threatening arrhythmias in non-ischemic dilated cardiomyopathy (DCM-SVA risk).
    Int J Cardiol. 2021;339:75-82.
    PubMed     Abstract available


  110. SINGH N, Singh A, Besser SA, Lang RM, et al
    Echocardiographic predictors of new-onset atrial arrhythmias in patients undergoing hematopoietic stem cell transplantation.
    Int J Cardiol. 2021;339:225-231.
    PubMed     Abstract available


  111. YANO M, Egami Y, Ukita K, Kawamura A, et al
    Impact of myocardial injury and inflammation due to ablation on the short-term and mid-term outcomes: Cryoballoon versus laser balloon ablation.
    Int J Cardiol. 2021;338:102-108.
    PubMed     Abstract available


    August 2021
  112. SEN J, Tonkin A, Varigos J, Fonguh S, et al
    Risk stratification of cardiovascular complications using CHA2DS2-VASc and CHADS2 scores in chronic atherosclerotic cardiovascular disease.
    Int J Cardiol. 2021;337:9-15.
    PubMed     Abstract available


  113. VINTER N, Frost L, Benjamin EJ
    Heart failure and atrial fibrillation - does heart failure subtype matter?
    Int J Cardiol. 2021 Aug 6. pii: S0167-5273(21)01216.
    PubMed    


    July 2021
  114. ONISHI N, Kaitani K, Nakagawa Y, Inoue K, et al
    The association between late-phase early recurrence within the blanking period after atrial fibrillation catheter ablation and long-term recurrence: Insights from a large-scale multicenter study.
    Int J Cardiol. 2021 Jul 31. pii: S0167-5273(21)01196.
    PubMed     Abstract available


  115. BAUMHARDT M, Pott A
    On the quest of the optimal blanking period - Can we predict early arrhythmia recurrence after atrial fibrillation ablation using biomarkers?
    Int J Cardiol. 2021 Jul 31. pii: S0167-5273(21)01201.
    PubMed    


  116. MATETIC A, Mohamed M, Miller RJH, Kolman L, et al
    Impact of cancer diagnosis on causes and outcomes of 5.9 million US patients with cardiovascular admissions.
    Int J Cardiol. 2021 Jul 29. pii: S0167-5273(21)01197.
    PubMed     Abstract available


  117. GHAFOURI K, Franke KB, Foo FS, Stiles MK, et al
    Clinical utility of cardiac magnetic resonance imaging to assess the left atrium before catheter ablation for atrial fibrillation - A systematic review and meta-analysis.
    Int J Cardiol. 2021 Jul 22. pii: S0167-5273(21)01175.
    PubMed     Abstract available


  118. OLSHANSKY B
    Sinus node dysfunction - A well-defined entity?
    Int J Cardiol. 2021;335:55-56.
    PubMed    


  119. HALASZ G, Cattaneo M, Piepoli M, Romano S, et al
    Pediatric athletes' ECG and diagnostic performance of contemporary ECG interpretation criteria.
    Int J Cardiol. 2021;335:40-46.
    PubMed     Abstract available


  120. NEDIOS S
    Screening for atrial fibrillation: Does cardiovascular disease reduce the probability of detection?
    Int J Cardiol. 2021 Jul 14. pii: S0167-5273(21)01097.
    PubMed    


  121. NJI MAM, Solomon SD, Chen LY, Shah AM, et al
    Association of heart failure subtypes and atrial fibrillation: Data from the Atherosclerosis Risk in Communities (ARIC) study.
    Int J Cardiol. 2021 Jul 8. pii: S0167-5273(21)01100.
    PubMed     Abstract available


    June 2021
  122. GOETTE A
    Is left atrial strain the pathophysiological link between transplanted stem cells and atrial fibrillation?
    Int J Cardiol. 2021 Jun 29. pii: S0167-5273(21)01081.
    PubMed    


  123. KIM MH, You SC, Sung JH, Jang E, et al
    Safety and long-term outcomes of catheter ablation according to sex in patients with atrial fibrillation: A nationwide cohort study.
    Int J Cardiol. 2021 Jun 18. pii: S0167-5273(21)00980.
    PubMed     Abstract available


  124. MITROI C, Garcia-Izquierdo E, Garcia-Lunar I, Castro-Urda V, et al
    Right ventricular function and dyssynchrony in Brugada syndrome: Highlighting the importance of the mechanical substrate in the right ventricular outflow tract.
    Int J Cardiol. 2021;333:233-238.
    PubMed     Abstract available


  125. BARCELLONA D, Mameli A, Cornacchini S, Perra F, et al
    Patients' adherence to oral anticoagulants therapy: Comparison between vitamin K antagonists and direct oral anticoagulants.
    Int J Cardiol. 2021;333:162-166.
    PubMed     Abstract available


  126. FAROUX L, Cruz-Gonzalez I, Arzamendi D, Freixa X, et al
    Short-term direct oral anticoagulation or dual antiplatelet therapy following left atrial appendage closure in patients with relative contraindications to chronic anticoagulation therapy.
    Int J Cardiol. 2021;333:77-82.
    PubMed     Abstract available


  127. GASPERETTI A, Targetti M, Olivotto I
    Anti-arrhythmic drugs in arrhythmogenic right ventricular cardiomyopathy: The importance of optimal beta-blocker dose titration.
    Int J Cardiol. 2021 Jun 15. pii: S0167-5273(21)00968.
    PubMed    


  128. DILAVERIS P, Tsioufis C
    The single-lead 14-day ECG patch EZYPRO(R): a new kid in the block.
    Int J Cardiol. 2021;332:89-90.
    PubMed    


  129. LIU CM, Chang SL, Yeh YH, Chung FP, et al
    Enhanced detection of cardiac arrhythmias utilizing 14-day continuous ECG patch monitoring.
    Int J Cardiol. 2021;332:78-84.
    PubMed     Abstract available


    May 2021
  130. DE LA TORRE HERNANDEZ JM, Ferreiro JL, Lopez-Palop R, Ojeda S, et al
    Antithrombotic strategies in elderly patients with atrial fibrillation revascularized with drug-eluting stents: PACO-PCI (EPIC-15) registry.
    Int J Cardiol. 2021 May 29. pii: S0167-5273(21)00848.
    PubMed     Abstract available


  131. LEE AC, Strugnell W, Vittinghoff E, Hamilton-Craig C, et al
    Electrophysiologic and imaging evidence for an occult myopathic substrate in patients with idiopathic ventricular arrhythmias.
    Int J Cardiol. 2021 May 25. pii: S0167-5273(21)00898.
    PubMed     Abstract available


  132. MAILLE B, Wilkin M, Million M, Resseguier N, et al
    Smartwatch Electrocardiogram and Artificial Intelligence for Assessing Cardiac-Rhythm Safety of Drug Therapy in the COVID-19 Pandemic. The QT-logs study.
    Int J Cardiol. 2021;331:333-339.
    PubMed     Abstract available


  133. BARISON A, Baritussio A, Cipriani A, De Lazzari M, et al
    Cardiovascular magnetic resonance: What clinicians should know about safety and contraindications.
    Int J Cardiol. 2021;331:322-328.
    PubMed     Abstract available


  134. VOSKOBOINIK A, McDonald C, Chieng D, O'Brien J, et al
    Acute electrical, autonomic and structural effects of binge drinking: Insights into the 'holiday heart syndrome'.
    Int J Cardiol. 2021;331:100-105.
    PubMed     Abstract available


  135. CHEN T, Liu G, Mu Y, Xu WH, et al
    Application of cardiac computed tomographic imaging and fluoroscopy fusion for guiding left atrial appendage occlusion.
    Int J Cardiol. 2021;331:289-295.
    PubMed     Abstract available


  136. SEGGEWISS H, Batzner A
    Surgical myectomy in HOCM: Still gold standard for septal reduction?
    Int J Cardiol. 2021;331:174-175.
    PubMed    


  137. WALSH R
    Desmin variants in cardiomyopathies - the hard yards in defining pathogenicity.
    Int J Cardiol. 2021;331:208-209.
    PubMed    


  138. FENDER AC, Dobrev D
    Potential antiarrhythmic actions of anticoagulants: Do they exist and can they be clinically unmasked?
    Int J Cardiol. 2021;331:73-74.
    PubMed    


  139. MANNINA C, Jin Z, Matsumoto K, Ito K, et al
    Frequency of cardiac arrhythmias in older adults: Findings from the Subclinical Atrial Fibrillation and Risk of Ischemic Stroke (SAFARIS) study.
    Int J Cardiol. 2021 May 6. pii: S0167-5273(21)00818.
    PubMed     Abstract available


  140. CAPPELLETTO C, Gregorio C, Barbati G, Romani S, et al
    Antiarrhythmic therapy and risk of cumulative ventricular arrhythmias in arrhythmogenic right ventricle cardiomyopathy.
    Int J Cardiol. 2021 May 4. pii: S0167-5273(21)00812.
    PubMed     Abstract available


  141. SHIN SY, Park JW
    Is the Left Atrial Appendage (LAA) anatomical shape really meaningless measure for stroke risk assessment?
    Int J Cardiol. 2021;330:80-81.
    PubMed    


  142. DI FLORIO A, Fusi C, Anselmi F, Cavigli L, et al
    Clinical management of young competitive athletes with premature ventricular beats: A prospective cohort study.
    Int J Cardiol. 2021;330:59-64.
    PubMed     Abstract available


  143. LIANG D, Shi R, Zheng KI, Zhou X, et al
    Clinical characteristics and outcomes in patients with echocardiographic left ventricular spontaneous echo contrast.
    Int J Cardiol. 2021;330:245-250.
    PubMed     Abstract available


  144. RAINA A
    When more speaks to less: New insights into arrhythmias in pulmonary hypertension from long term continuous monitoring.
    Int J Cardiol. 2021 May 1. pii: S0167-5273(21)00743.
    PubMed    


    April 2021
  145. LANGER A, Healey JS, Quinn FR, Honos G, et al
    Detection of atrial fibrillation in asymptomatic at-risk individuals.
    Int J Cardiol. 2021 Apr 28. pii: S0167-5273(21)00737.
    PubMed     Abstract available


  146. MOLLER S
    Prolonged QT-interval in cirrhosis: is it reversible?
    Int J Cardiol. 2021;329:113-114.
    PubMed    


  147. YANG YH, Wang KX, Ma PP, Zhang RF, et al
    His-purkinje system pacing upgrade improve the heart performances in patients suffering from pacing-induced cardiomyopathy with or without permanent atrial fibrillation.
    Int J Cardiol. 2021 Apr 9. pii: S0167-5273(21)00648.
    PubMed     Abstract available


  148. NISSAN R
    Measuring apixaban levels in the elderly patient with non-valvular atrial fibrillation.
    Int J Cardiol. 2021 Apr 8. pii: S0167-5273(21)00644.
    PubMed    


  149. ANDERSEN MO, Diederichsen SZ, Svendsen JH, Carlsen J, et al
    Assessment of cardiac arrhythmias using long-term continuous monitoring in patients with pulmonary hypertension.
    Int J Cardiol. 2021 Apr 2. pii: S0167-5273(21)00551.
    PubMed     Abstract available


  150. PERNOLLET P, Gras M, Bidegain N, Gal FL, et al
    Impact of the atrial lead pacing site regarding atrial fibrillation onset in patients with sinus node dysfunction.
    Int J Cardiol. 2021 Apr 1. pii: S0167-5273(21)00633.
    PubMed     Abstract available


  151. FREDGART MH, Lindholt JS, Brandes A, Steffensen FH, et al
    Prognostic importance of left atrial size measured by non-contrast cardiac computed tomography - A DANCAVAS study.
    Int J Cardiol. 2021;328:220-226.
    PubMed     Abstract available


  152. ISAKSEN JL, Ghouse J, Graff C, Olesen MS, et al
    Electrocardiographic T-wave morphology and risk of mortality.
    Int J Cardiol. 2021;328:199-205.
    PubMed     Abstract available


  153. KHARBANDA RK, Lodder L, Ragab AAY, de Jong PL, et al
    Early and late post-operative arrhythmias after surgical myectomy: 45 years of follow-up.
    Int J Cardiol. 2021;328:63-68.
    PubMed     Abstract available


  154. FRANKE KB, Marshall H, Kennewell P, Pham HD, et al
    Risk and predictors of sudden death in cardiac sarcoidosis: A systematic review and meta-analysis.
    Int J Cardiol. 2021;328:130-140.
    PubMed     Abstract available


    March 2021
  155. BAY M, Vollenweider P, Marques-Vidal P, Schlapfer J, et al
    Clinical factors associated with the intraventricular conduction disturbances in Swiss middle-aged adults: The CoLaus|PsyCoLaus study.
    Int J Cardiol. 2021;327:201-208.
    PubMed     Abstract available


  156. STRAW S, Witte KK
    Closing the loop: Delivering personalised care for patients with cryptogenic stroke.
    Int J Cardiol. 2021;327:100-101.
    PubMed    


  157. KAWAMATSU N, Ishizu T, Machino-Ohtsuka T, Masuda K, et al
    Direct oral anticoagulant use and outcomes in adult patients with Fontan circulation: A multicenter retrospective cohort study.
    Int J Cardiol. 2021;327:74-79.
    PubMed     Abstract available


  158. KRISHNAPPA D, Wang W, Rooney MR, Norby FL, et al
    Life's Simple 7 cardiovascular health score and premature atrial contractions: The atherosclerosis risk in communities (ARIC) study.
    Int J Cardiol. 2021 Mar 3. pii: S0167-5273(21)00394.
    PubMed     Abstract available


  159. KO J, Koshy AN, Han HC, Weinberg L, et al
    Effect of liver transplantation on QT-interval prolongation and impact on mortality.
    Int J Cardiol. 2021;326:158-163.
    PubMed     Abstract available


  160. DE HEIDE J, de Wit A, Bhagwandien RE, Assaf A, et al
    Efficacy and safety of direct oral anticoagulants in patients undergoing elective electrical cardioversion: A real-world patient population.
    Int J Cardiol. 2021;326:98-102.
    PubMed     Abstract available


    February 2021
  161. ISBISTER JC, Nowak N, Butters A, Yeates L, et al
    "Concealed cardiomyopathy" as a cause of previously unexplained sudden cardiac arrest.
    Int J Cardiol. 2021;324:96-101.
    PubMed     Abstract available


  162. ZHANG X, Jin Q, Kong D, Jiang Y, et al
    Comparison of fluoroscopy and transesophageal echocardiogram for intra-procedure device surveillance assessment during implantation of Watchman.
    Int J Cardiol. 2021;324:72-77.
    PubMed     Abstract available


  163. MADIAS JE
    Electrocardiogram features and course in patients with takotsubo syndrome.
    Int J Cardiol. 2021;324:22.
    PubMed    


    January 2021
  164. NOURAEI H, Rabkin SW
    A new approach to the clinical subclassification of heart failure with preserved ejection fraction.
    Int J Cardiol. 2021 Jan 30. pii: S0167-5273(21)00134.
    PubMed     Abstract available


  165. DUDZINSKA-SZCZERBA K, Michalowska I, Piotrowski R, Sikorska A, et al
    Assessment of the left atrial appendage morphology in patients after ischemic stroke - The ASSAM study.
    Int J Cardiol. 2021 Jan 29. pii: S0167-5273(21)00080.
    PubMed     Abstract available


  166. CAMELI M, Pastore MC, Mandoli GE
    Left atrial strain: A key element for the evaluation of patients with HFpEF.
    Int J Cardiol. 2021;323:197-198.
    PubMed    


  167. BREITENSTEIN A, Saguner AM, Gasperetti A, Hofer D, et al
    Assessment of injury current during leadless pacemaker implantation.
    Int J Cardiol. 2021;323:113-117.
    PubMed     Abstract available


  168. ANILKUMAR A, Moore EJ, Gall AJ, Sammut E, et al
    QTc interval in survivors of out of hospital cardiac arrest.
    Int J Cardiol. 2021;323:118-123.
    PubMed     Abstract available


  169. KUSCHYK J, Muller-Leisse J, Duncker D, Tulumen E, et al
    Comparison of transvenous vs subcutaneous defibrillator therapy in patients with cardiac arrhythmia syndromes and genetic cardiomyopathies.
    Int J Cardiol. 2021;323:100-105.
    PubMed     Abstract available


  170. HWANG J, Lee SR, Park HS, Lee YS, et al
    Adherence to dabigatran and the influence of dabigatran-induced gastrointestinal discomfort in the real-world practice.
    Int J Cardiol. 2021;323:77-82.
    PubMed     Abstract available


  171. NARAYAN P, Angelini GD
    Warm blood or cold cardioplegia- Is this the final answer?
    Int J Cardiol. 2021;322:99-100.
    PubMed    


  172. GATZOULIS KA, Arsenos P, Antoniou CK, Dilaveris P, et al
    Signal-averaged electrocardiogram findings among right ventricular arrhythmogenic cardiomyopathy (ARVC) patients: Do they have a place in ARVC management?
    Int J Cardiol. 2021;322:175.
    PubMed    


  173. SCOGNAMIGLIO G, Fusco F, Hankel TC, Bouma BJ, et al
    Safety and efficacy of non-vitamin K antagonist oral anticoagulants for prevention of thromboembolism in adults with systemic right ventricle: Results from the NOTE international registry.
    Int J Cardiol. 2021;322:129-134.
    PubMed     Abstract available


    September 2020
  174. SCALLY C, Choo W, Rudd A, Neil C, et al
    The early dynamic of ECG in takotsubo syndrome presenting with ST-elevation: A comparison with age and gender-matched ST-elevation myocardial infarction.
    Int J Cardiol. 2020 Sep 10. pii: S0167-5273(20)33804.
    PubMed    


    April 2020
  175. ANSELMINO M, Matta M, Saglietto A, Gallo C, et al
    Long-term atrial arrhythmias incidence after heart transplantation.
    Int J Cardiol. 2020 Apr 11. pii: S0167-5273(20)30601.
    PubMed     Abstract available


    February 2020
  176. DEHGHANI P, Singer Z, Morrison J, Booker J, et al
    Characteristics and usefulness of unintended premature ventricular contraction during invasive assessment of aortic stenosis.
    Int J Cardiol. 2020 Feb 28. pii: S0167-5273(20)30202.
    PubMed     Abstract available


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