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Explore this week’s CC Journal Club

90‑sec video • 4‑min audio • paper abstracts

This week, 27 April 2025:

  1. Treatment-resistant hypertension
  2. Influenza transmission
  3. Nanoplastics in human brains
  4. Malaria elimination
  5. Chikungunya vaccine

  Breast Cancer

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Articles published in J Biol Chem

Retrieve available abstracts of 27 articles:
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Single Articles


    April 2025
  1. -M FAN TW, Yan J, Goncalves CFL, Islam JMM, et al
    Patient-derived organotypic tissue cultures as a platform to evaluate metabolic reprogramming in breast cancer patients.
    J Biol Chem. 2025 Apr 8:108495. doi: 10.1016/j.jbc.2025.108495.
    PubMed     Abstract available


    March 2025
  2. HU Y, Bian J, Chen W, Shi J, et al
    Androgen receptor-induced lncRNA SOX2-OT promotes triple-negative breast cancer tumorigenesis via targeting miR-320a-5p/CCR5 axis.
    J Biol Chem. 2025 Mar 19:108428. doi: 10.1016/j.jbc.2025.108428.
    PubMed     Abstract available


  3. SENDANAYAKE LR, Pokhrel R, Holub JM
    Surveying helix 12 dynamics within constitutively active estrogen receptors using bipartite tetracysteine display.
    J Biol Chem. 2025;301:108231.
    PubMed     Abstract available


    February 2025
  4. SONG X, Liu S, Zeng Y, Cai Y, et al
    BANCR-Containing Extracellular Vesicles Enhance Breast Cancer Resistance.
    J Biol Chem. 2025 Feb 11:108304. doi: 10.1016/j.jbc.2025.108304.
    PubMed     Abstract available


  5. BOBBITT JR, Cuellar-Vite L, Weber-Bonk KL, Yancey MR, et al
    Targeting the mitotic kinase NEK2 enhances CDK4/6 inhibitor efficacy by potentiating genome instability.
    J Biol Chem. 2025;301:108196.
    PubMed     Abstract available


    January 2025
  6. BAGCHI A, Bhattacharya A, Bera A, Basak D, et al
    PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer.
    J Biol Chem. 2025 Jan 27:108239. doi: 10.1016/j.jbc.2025.108239.
    PubMed     Abstract available


  7. PAUL S, Chatterjee A, Das K, Ray A, et al
    Thrombin confers chemotherapeutic resistance by promoting transcriptional induction and post-translational stabilization of pro-survival MCL1 in TNBC.
    J Biol Chem. 2025;301:108025.
    PubMed     Abstract available


  8. MCDERMOTT N, O'Shea S, Rieger L, Cox OT, et al
    beta(1)-integrin controls IGF-1R internalization and intracellular signaling.
    J Biol Chem. 2025;301:108021.
    PubMed     Abstract available


    December 2024
  9. YU S, Si Y, Xu M, Wang Y, et al
    Downregulation of the splicing regulator NSRP1 confers resistance to CDK4/6 inhibitors via activation of interferon signaling in breast cancer.
    J Biol Chem. 2024 Dec 10:108070. doi: 10.1016/j.jbc.2024.108070.
    PubMed     Abstract available


  10. LETSON J, Ren G, Zheng X, Sweef O, et al
    Reduced S-nitrosylation of TGFbeta1 elevates its binding affinity toward the receptor and promotes fibrogenic signaling in the breast.
    J Biol Chem. 2024;300:108011.
    PubMed     Abstract available


  11. PAN KW, Chen HC
    Perinuclear assembly of vimentin intermediate filaments induces cancer cell nuclear dysmorphia.
    J Biol Chem. 2024;300:107981.
    PubMed     Abstract available


    November 2024
  12. MASSEY S, Kongchan N, Gao Y, Chaudhury A, et al
    PKC-mediated phosphorylation governs the stability and function of CELF1 as a driver of EMT in breast epithelial cells.
    J Biol Chem. 2024;300:107826.
    PubMed     Abstract available


    October 2024
  13. OROBATOR ON, Mertens RT, Obisesan OA, Awuah SG, et al
    Energy and endoplasmic reticulum stress induction by gold(III) dithiocarbamate and 2-deoxyglucose synergistically trigger cell death in breast cancer.
    J Biol Chem. 2024 Oct 29:107949. doi: 10.1016/j.jbc.2024.107949.
    PubMed     Abstract available


  14. SAUNDERS H, Holloran S, Trinca G, Artigues A, et al
    Site specific O-GlcNAcylation of progesterone receptor (PR) supports PR attenuation of interferon stimulated genes (ISGs) and tumor growth in breast cancer.
    J Biol Chem. 2024 Oct 10:107886. doi: 10.1016/j.jbc.2024.107886.
    PubMed     Abstract available


  15. ROTENBERG N, Feldman M, Shirian J, Hockla A, et al
    Engineered TIMP2 with narrow MMP-9 specificity is an effective inhibitor of invasion and proliferation of triple negative breast cancer cells.
    J Biol Chem. 2024 Oct 9:107867. doi: 10.1016/j.jbc.2024.107867.
    PubMed     Abstract available


  16. THI K, Del Toro K, Licon-Munoz Y, Sayaman RW, et al
    Comprehensive identification, isolation, and culture of human breast cell types.
    J Biol Chem. 2024;300:107637.
    PubMed     Abstract available


    September 2024
  17. BERNA-ERRO A, Lopez JJ, Jardin I, Sanchez-Collado J, et al
    Differential functional role of Orai1 variants in constitutive Ca(2+) entry and calcification in luminal breast cancer cells.
    J Biol Chem. 2024 Sep 18:107786. doi: 10.1016/j.jbc.2024.107786.
    PubMed     Abstract available


  18. ZHANG J, Chen Y, Gong X, Yang Y, et al
    GATA factor TRPS1, a new DNA repair protein, cooperates with reversible PARylation to promote chemoresistance in breast cancer patients.
    J Biol Chem. 2024 Sep 12:107780. doi: 10.1016/j.jbc.2024.107780.
    PubMed     Abstract available


  19. CHEN X, Li D, Su Q, Ling X, et al
    SENP3 mediates the deSUMOylation and degradation of YAP1 to regulate the progression of triple-negative breast cancer.
    J Biol Chem. 2024 Sep 11:107764. doi: 10.1016/j.jbc.2024.107764.
    PubMed     Abstract available


  20. QIAN T, Bai F, Zhang S, Xu Y, et al
    USP11 deubiquitinates E-cadherin and maintains luminal fate of mammary tumor cells to suppress breast cancer.
    J Biol Chem. 2024 Sep 11:107768. doi: 10.1016/j.jbc.2024.107768.
    PubMed     Abstract available


    August 2024
  21. TANG K, Yin T, Deng B, Wang M, et al
    USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion.
    J Biol Chem. 2024 Aug 9:107672. doi: 10.1016/j.jbc.2024.107672.
    PubMed     Abstract available


    July 2024
  22. PERRON T, Boissan M, Bieche I, Courtois L, et al
    CYYR1 promotes the degradation of the E3 ubiquitin ligase WWP1 and is associated with favorable prognosis in breast cancer.
    J Biol Chem. 2024 Jul 24:107601. doi: 10.1016/j.jbc.2024.107601.
    PubMed     Abstract available


    June 2024
  23. GUO Q, Zhao J, Li Y, Zhang C, et al
    CK2-HTATSF1-TOPBP1 signaling axis modulates tumor chemotherapy response.
    J Biol Chem. 2024;300:107377.
    PubMed     Abstract available


    May 2024
  24. PANDEY A, Kakani P, Shukla S
    CTCF and BORIS-mediated Autophagy regulation via Alternative splicing of BNIP3L in Breast Cancer.
    J Biol Chem. 2024 May 27:107416. doi: 10.1016/j.jbc.2024.107416.
    PubMed     Abstract available


  25. DUAN L, Tadi MJ, O'Hara KM, Maki CG, et al
    Novel markers of MCL1 inhibitor sensitivity in triple negative breast cancer cells.
    J Biol Chem. 2024 May 16:107375. doi: 10.1016/j.jbc.2024.107375.
    PubMed     Abstract available


    April 2024
  26. YANG P, Li Y, Hou J, Wu D, et al
    Blockade of a novel MAP4K4-LATS2-SASH1-YAP1 cascade inhibits tumorigenesis and metastasis in luminal breast cancer.
    J Biol Chem. 2024 Apr 22:107309. doi: 10.1016/j.jbc.2024.107309.
    PubMed     Abstract available


  27. GOEL HL, Karner ER, Kumar A, Mukhopadhyay D, et al
    YAP/TAZ-mediated regulation of laminin 332 is enabled by beta4 integrin repression of ZEB1 to promote ferroptosis resistance.
    J Biol Chem. 2024;300:107202.
    PubMed     Abstract available


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