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COVID-19: Daily Top 10 Papers

  Biliary Tract Diseases

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Articles published in Hepatology

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    September 2021
  1. CARAPETO F, Bozorgui B, Shroff RT, Chagani S, et al
    The Immunogenomic Landscape of Resected Intrahepatic Cholangiocarcinoma.
    Hepatology. 2021 Sep 12. doi: 10.1002/hep.32150.
    PubMed     Abstract available

  2. AN J, Kim D, Oh B, Oh YJ, et al
    Comprehensive characterization of viral integrations and genomic aberrations in HBV-infected intrahepatic cholangiocarcinomas.
    Hepatology. 2021 Sep 3. doi: 10.1002/hep.32135.
    PubMed     Abstract available

    August 2021
  3. VEDELD HM, Grimsrud MM, Andresen K, Pharo HD, et al
    Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile.
    Hepatology. 2021 Aug 26. doi: 10.1002/hep.32125.
    PubMed     Abstract available

  4. LINDOR KD, Bowlus CL, Boyer J, Levy C, et al
    Primary Biliary Cholangitis: 2021 Practice Guidance Update from the American Association for the Study of Liver Diseases.
    Hepatology. 2021 Aug 24. doi: 10.1002/hep.32117.
    PubMed     Abstract available

  5. ARORA M, Bogenberger JM, Abdelrahman AM, Yonkus J, et al
    Synergistic Combination of Cytotoxic Chemotherapy and Cyclin Dependent Kinase 4/6 Inhibitors in Biliary Tract Cancers.
    Hepatology. 2021 Aug 18. doi: 10.1002/hep.32102.
    PubMed     Abstract available

  6. AMARACHINTHA SP, Mourya R, Ayabe H, Yang L, et al
    Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.
    Hepatology. 2021 Aug 15. doi: 10.1002/hep.32107.
    PubMed     Abstract available

  7. EL KASMI KC, Ghosh S, Anderson AL, Devereaux MW, et al
    Pharmacologic Activation of Hepatic Farnesoid X Receptor Prevents Parenteral Nutrition Associated Cholestasis in Mice.
    Hepatology. 2021 Aug 13. doi: 10.1002/hep.32101.
    PubMed     Abstract available

  8. LIN Y, Cai Q, Chen Y, Shi T, et al
    CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma via 5-lipoxygenase.
    Hepatology. 2021 Aug 13. doi: 10.1002/hep.32099.
    PubMed     Abstract available

  9. ZENG R, Sha W, Leung FW, Chen H, et al
    Letter to the Editor: Proton pump inhibitors and Biliary Tract Cancer Risk: Causality or Reverse Causality?
    Hepatology. 2021 Aug 5. doi: 10.1002/hep.32090.
    PubMed     Abstract available

    July 2021
  10. PANT K, Peixoto E, Richard S, Biswas A, et al
    Histone Deacetylase SIRT1 promotes loss of primary cilia in Cholangiocarcinoma.
    Hepatology. 2021 Jul 29. doi: 10.1002/hep.32080.
    PubMed     Abstract available

  11. CAI P, Mao X, Zhao J, Nie L, et al
    Farnesoid X Receptor is Required for the Redifferentiation of Bi-potential Progenitor Cells during Biliary-Mediated Zebrafish Liver Regeneration.
    Hepatology. 2021 Jul 28. doi: 10.1002/hep.32076.
    PubMed     Abstract available

  12. GHOSH S, Devereaux MW, Anderson AL, Gehrke S, et al
    NFkappaB regulation of LRH-1 and ABCG5/8 potentiates phytosterol role in the pathogenesis of parenteral nutrition associated cholestasis.
    Hepatology. 2021 Jul 26. doi: 10.1002/hep.32071.
    PubMed     Abstract available

  13. LOBE C, Vallette M, Arbelaiz A, Gonzalez-Sanchez E, et al
    ZEB1 promotes cholangiocarcinoma progression through tumor dedifferentiation and tumor-stroma paracrine signaling.
    Hepatology. 2021 Jul 23. doi: 10.1002/hep.32069.
    PubMed     Abstract available

  14. ZHANG JW, Yang X, Ding HR, Zhang L, et al
    Is aspirin a drug or just a marker for biliary cancer?
    Hepatology. 2021 Jul 9. doi: 10.1002/hep.32052.
    PubMed     Abstract available

  15. LEE MH, Huang YH, Koshiol J
    Response Letter Regarding Article, "Postdiagnosis aspirin use associated with decreased biliary tract cancer-specific mortality in a large nationwide cohort".
    Hepatology. 2021 Jul 8. doi: 10.1002/hep.32051.
    PubMed     Abstract available

  16. DE GOEIJ FHC, Schlegel A, Muiesan P, Guarrera JV, et al
    Hypothermic oxygenated machine perfusion protects from cholangiopathy in DCD liver transplantation.
    Hepatology. 2021 Jul 7. doi: 10.1002/hep.32044.
    PubMed     Abstract available

    June 2021
  17. VARTAK N, Drasdo D, Geisler F, Itoh T, et al
    On the mechanisms of biliary flux.
    Hepatology. 2021 Jun 23. doi: 10.1002/hep.32027.
    PubMed     Abstract available

  18. SHI S, Chen S, Verstegen MMA, Pan Q, et al
    Letter to the Editor: HMGB1 Release is a Newly Identified Driver of Inflammation in the Pathogenesis of Biliary Atresia.
    Hepatology. 2021 Jun 23. doi: 10.1002/hep.32026.
    PubMed     Abstract available

  19. MEADOWS V, Kennedy L, Ekser B, Kyritsi K, et al
    Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis via Farnesoid X Receptor Signaling.
    Hepatology. 2021 Jun 23. doi: 10.1002/hep.32028.
    PubMed     Abstract available

  20. BARRON-MILLAR B, Ogle L, Mells G, Flack S, et al
    The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis.
    Hepatology. 2021 Jun 15. doi: 10.1002/hep.32011.
    PubMed     Abstract available

  21. LEE YT, Wang JJ, Luu M, Noureddin M, et al
    Comparison of Clinical Features and Outcomes between Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma in the United States.
    Hepatology. 2021 Jun 11. doi: 10.1002/hep.32007.
    PubMed     Abstract available

    May 2021
  22. LEPORE A, Choy PM, Lee NC, Carella MA, et al
    Phosphorylation and stabilization of PIN1 by JNK promote intrahepatic cholangiocarcinoma growth.
    Hepatology. 2021 May 28. doi: 10.1002/hep.31983.
    PubMed     Abstract available

  23. SUN LY, Hu JY, Liang L, Tong XM, et al
    Letter to the Editor: Is Male Gender Associated with Increased Liver-related Mortality in Primary Biliary Cholangitis and Cirrhosis?
    Hepatology. 2021 May 22. doi: 10.1002/hep.31916.
    PubMed     Abstract available

  24. JOHN BV, Deng Y, Martin P, Levy C, et al
    Response to "Is Male Gender Associated with Increased Liver-related Mortality in Primary Biliary Cholangitis and Cirrhosis?"
    Hepatology. 2021 May 22. doi: 10.1002/hep.31917.
    PubMed     Abstract available

  25. KAMAL H, Sadr-Azodi O, Engstrand L, Brusselaers N, et al
    Association between Proton Pump Inhibitor Use and Biliary Tract Cancer Risk: a Swedish Population-Based Cohort Study.
    Hepatology. 2021 May 21. doi: 10.1002/hep.31914.
    PubMed     Abstract available

  26. MARTINEZ M, Perito ER, Valentino P, Mack CL, et al
    Recurrence of primary sclerosing cholangitis after liver transplant in children: an international observational study.
    Hepatology. 2021 May 18. doi: 10.1002/hep.31911.
    PubMed     Abstract available

  27. JANSSON H, Sparrelid E
    Letter to the Editor: The role of surgery in multiple intrahepatic cholangiocarcinoma should not be dismissed without further analysis.
    Hepatology. 2021 May 18. doi: 10.1002/hep.31905.
    PubMed     Abstract available

  28. LAMARCA A, Santos-Laso A, Utpatel K, La Casta A, et al
    Reply to (20-1119.R1) Surgery for advanced intrahepatic cholangiocarcinoma warrants further investigation.
    Hepatology. 2021 May 17. doi: 10.1002/hep.31904.
    PubMed     Abstract available

  29. GENTILINI A, Lori G, Caligiuri A, Raggi C, et al
    Extracellular signal-regulated kinase 5 regulates the malignant phenotype of cholangiocarcinoma cells.
    Hepatology. 2021 May 6. doi: 10.1002/hep.31888.
    PubMed     Abstract available

  30. LIAO SF, Koshiol J, Huang YH, Jackson SS, et al
    Postdiagnosis aspirin use associated with decreased biliary tract cancer-specific mortality in a large nationwide cohort.
    Hepatology. 2021 May 3. doi: 10.1002/hep.31879.
    PubMed     Abstract available

  31. VAN DER LAAN LJW, Roos FJM, Verstegen MMA
    Bile Duct Repair in Human Liver Grafts: Effective Cholangiocyte Organoid Engraftment and Plasticity.
    Hepatology. 2021 May 2. doi: 10.1002/hep.31877.
    PubMed     Abstract available

    April 2021
  32. YOON JG, Kim MH, Jang M, Kim H, et al
    Molecular Characterization of Biliary Tract Cancer Predicts Chemotherapy and PD-1/PD-L1 Blockade Responses.
    Hepatology. 2021 Apr 21. doi: 10.1002/hep.31862.
    PubMed     Abstract available

    March 2021
  33. DI-LUOFFO M, Pirenne S, Saandi T, Loriot A, et al
    A novel mouse model of cholangiocarcinoma uncovers a role for Tensin-4 in tumor progression.
    Hepatology. 2021 Mar 26. doi: 10.1002/hep.31834.
    PubMed     Abstract available

  34. BOERNER T, Drill E, Pak LM, Nguyen B, et al
    Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma.
    Hepatology. 2021 Mar 25. doi: 10.1002/hep.31829.
    PubMed     Abstract available

  35. LUO X, Campbell NA, He L, O'Brien DR, et al
    SULF2 monoclonal antibody 5D5 suppresses human cholangiocarcinoma xenograft growth via regulation of a SULF2-PDGFRbeta-YAP signaling axis.
    Hepatology. 2021 Mar 18. doi: 10.1002/hep.31817.
    PubMed     Abstract available

  36. WADA Y, Shimada M, Yamamura K, Toshima T, et al
    A transcriptomic signature for risk-stratification and recurrence prediction in intrahepatic cholangiocarcinoma.
    Hepatology. 2021 Mar 16. doi: 10.1002/hep.31803.
    PubMed     Abstract available

  37. CRISTOFERI L, Calvaruso V, Overi D, Vigano M, et al
    Accuracy of Transient Elastography in assessing fibrosis at diagnosis in naive patients with Primary Biliary Cholangitis: a dual cut-off approach.
    Hepatology. 2021 Mar 16. doi: 10.1002/hep.31810.
    PubMed     Abstract available

  38. KENDRE G, Marhenke S, Lorz G, Becker D, et al
    The co-mutational spectrum determines the therapeutic response in murine FGFR2 fusion - driven cholangiocarcinoma.
    Hepatology. 2021 Mar 11. doi: 10.1002/hep.31799.
    PubMed     Abstract available

  39. VAN WESSEL DBE, Thompson RJ, Gonzales E, Jankowska I, et al
    Impact of Genotype, Serum Bile Acids, and Surgical Biliary Diversion on Native Liver Survival in FIC1 Deficiency.
    Hepatology. 2021 Mar 5. doi: 10.1002/hep.31787.
    PubMed     Abstract available

  40. ZHOU Y, Chen Y, Zhang X, Xu Q, et al
    Brg1 Inhibition Prevents Liver Fibrosis and Cholangiocarcinoma by Attenuating Progenitor Expansion.
    Hepatology. 2021 Mar 2. doi: 10.1002/hep.31780.
    PubMed     Abstract available

    February 2021
  41. CHIU M, Garabon J, Chen L, Karp N, et al
    Mevalonic Aciduria Associated with Intrahepatic Bile Duct Paucity.
    Hepatology. 2021 Feb 27. doi: 10.1002/hep.31778.
    PubMed     Abstract available

  42. JOHNSON KM, Fischer RT, Holtmann GJ, Shah A, et al
    Letter to the editor: Oral vancomycin versus no therapy for pediatric primary sclerosing cholangitis.
    Hepatology. 2021 Feb 26. doi: 10.1002/hep.31764.
    PubMed     Abstract available

  43. SHIOTA J, Samuelson LC, Razumilava N
    Hepatobiliary organoids and their applications for studies of liver health and disease: are we there yet?
    Hepatology. 2021 Feb 26. doi: 10.1002/hep.31772.
    PubMed     Abstract available

  44. JOHN BV, Aitcheson G, Schwartz KB, Shabbir Khakoo N, et al
    Male Gender is Associated with Higher Rates of Liver-related Mortality in Primary Biliary Cholangitis and Cirrhosis.
    Hepatology. 2021 Feb 26. doi: 10.1002/hep.31776.
    PubMed     Abstract available

  45. MOHANTY SK, Donnelly B, Temple H, Ortiz-Perez A, et al
    HMGB1 release by cholangiocytes governs biliary atresia pathogenesis and correlates with increases in afflicted infants.
    Hepatology. 2021 Feb 8. doi: 10.1002/hep.31745.
    PubMed     Abstract available

    Letter to the Editor: Intravital dynamic and correlative imaging reveals diffusion-dominated canalicular and flow-augmented ductular bile flux.
    Hepatology. 2021 Feb 8. doi: 10.1002/hep.31746.
    PubMed     Abstract available

  47. LAMARCA A, Santos-Laso A, Utpatel K, La Casta A, et al
    Reply to "Does multiple intrahepatic cholangiocarcinoma worsen prognosis as "M1" stage?"; multiple primaries vs liver metastases.
    Hepatology. 2021 Feb 7. doi: 10.1002/hep.31740.
    PubMed     Abstract available

  48. ZHANG XF, Lv Y, Pawlik TM
    Letter to the editor: Does multiple intrahepatic cholangiocarcinoma worsen prognosis as "M1" stage?
    Hepatology. 2021 Feb 6. doi: 10.1002/hep.31741.
    PubMed     Abstract available

    January 2021
  49. ITOH A, Adams D, Huang W, Wu Y, et al
    Enoxacin upregulates microRNA biogenesis and downregulates cytotoxic CD8 T cell function in autoimmune cholangitis.
    Hepatology. 2021 Jan 19. doi: 10.1002/hep.31724.
    PubMed     Abstract available

  50. LI J, Ye X, He S
    Letter to the Editor: Imaging monitoring of primary sclerosing cholangitis patients.
    Hepatology. 2021 Jan 11. doi: 10.1002/hep.31709.
    PubMed     Abstract available

  51. ASSIS DN, Levy C
    Oral Vancomycin or Ursodeoxycholic acid for Pediatric Primary Sclerosing Cholangitis? The Uncontroversial Need for Randomized Controlled Trials.
    Hepatology. 2021 Jan 5. doi: 10.1002/hep.31702.
    PubMed     Abstract available

    December 2020
  52. KOUKOULIOTI E, Ziagaki A, Weber SN, Lammert F, et al
    Long-term colestyramine treatment prevents cholestatic attacks in refractory benign recurrent intrahepatic cholestasis type 1 disease.
    Hepatology. 2020 Dec 5. doi: 10.1002/hep.31671.
    PubMed     Abstract available

    November 2020
    Ketamine-Induced Sclerosing Cholangitis (KISC) in a Critically Ill Patient with COVID-19.
    Hepatology. 2020 Nov 23. doi: 10.1002/hep.31650.
    PubMed     Abstract available

  54. MOUSA OY, Juran BD, McCauley BM, Vesterhus MN, et al
    Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation.
    Hepatology. 2020 Nov 23. doi: 10.1002/hep.31652.
    PubMed     Abstract available

  55. KUNST RF, Verkade HJ, Oude Elferink RPJ, van de Graaf SFJ, et al
    Targeting the four pillars of enterohepatic bile salt cycling; lessons from genetics and pharmacology.
    Hepatology. 2020 Nov 22. doi: 10.1002/hep.31651.
    PubMed     Abstract available

  56. SATO K, Zhang W, Safarikia S, Isidan A, et al
    Organoids and spheroids as novel models for studying cholestatic liver injury and cholangiocarcinoma.
    Hepatology. 2020 Nov 22. doi: 10.1002/hep.31653.
    PubMed     Abstract available

  57. COLYN L, Barcena-Varela M, Alvarez-Sola G, Latasa MU, et al
    Dual targeting of G9a and DNMT1 for the treatment of experimental cholangiocarcinoma.
    Hepatology. 2020 Nov 22. doi: 10.1002/hep.31642.
    PubMed     Abstract available

  58. MEADOWS V, Francis H
    DCLK1 in Cholangiocarcinoma: Is this the biomarker and target we've been looking for?
    Hepatology. 2020 Nov 11. doi: 10.1002/hep.31630.
    PubMed     Abstract available

  59. SMETS L, Verbeek J, Korf H, van der Merwe S, et al
    Improved markers of cholestatic liver injury in patients with primary biliary cholangitis treated with obeticholic acid and bezafibrate.
    Hepatology. 2020 Nov 3. doi: 10.1002/hep.31613.
    PubMed     Abstract available

    October 2020
  60. XU Y, Zhu Y, Hu S, Xu Y, et al
    Hepatocyte nuclear factor 4alpha prevents the steatosis-to-NASH progression by regulating p53 and bile acid signaling.
    Hepatology. 2020 Oct 23. doi: 10.1002/hep.31604.
    PubMed     Abstract available

  61. LAMARCA A, Santos-Laso A, Utpatel K, La Casta A, et al
    Liver metastases of intrahepatic cholangiocarcinoma: implications for a potential new staging system.
    Hepatology. 2020 Oct 18. doi: 10.1002/hep.31598.
    PubMed     Abstract available

  62. BRAGELMANN J, Barahona Ponce C, Marcelain K, Roessler S, et al
    Epigenome-wide analysis of methylation changes in the sequence of gallstone disease, dysplasia, and gallbladder cancer.
    Hepatology. 2020 Oct 5. doi: 10.1002/hep.31585.
    PubMed     Abstract available

  63. KUNZMANN LK, Schoknecht T, Poch T, Henze L, et al
    Monocytes as Potential Mediators of Pathogen-Induced T-Helper 17 Differentiation in Patients With Primary Sclerosing Cholangitis (PSC).
    Hepatology. 2020;72:1310-1326.
    PubMed     Abstract available

    September 2020
  64. NEVI L, Di Matteo S, Carpino G, Zizzari I, et al
    DCLK1, a putative novel stem cell marker in human cholangiocarcinoma.
    Hepatology. 2020 Sep 25. doi: 10.1002/hep.31571.
    PubMed     Abstract available

  65. EATON JE, Welle CL, Bakhshi Z, Sheedy SP, et al
    Early cholangiocarcinoma detection with magnetic resonance imaging versus ultrasound in primary sclerosing cholangitis.
    Hepatology. 2020 Sep 25. doi: 10.1002/hep.31575.
    PubMed     Abstract available

  66. CHEN D, Wu H, Feng X, Chen Y, et al
    DNA Methylation of CNRIP1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through Suppressing Parkin-Dependent PKM2 Ubiquitination.
    Hepatology. 2020 Sep 21. doi: 10.1002/hep.31561.
    PubMed     Abstract available

    Oral vancomycin, ursodeoxycholic acid or no therapy for pediatric primary sclerosing cholangitis: a matched analysis.
    Hepatology. 2020 Sep 18. doi: 10.1002/hep.31560.
    PubMed     Abstract available

  68. CHEN L, Zhou T, White T, O'Brien A, et al
    The apelin-apelin receptor axis triggers cholangiocyte proliferation and liver fibrosis during mouse models of cholestasis.
    Hepatology. 2020 Sep 7. doi: 10.1002/hep.31545.
    PubMed     Abstract available

  69. BARAHONA PONCE C, Scherer D, Brinster R, Boekstegers F, et al
    Gallstones, Body Mass Index, C-reactive Protein and Gallbladder Cancer - Mendelian Randomization Analysis of Chilean and European Genotype Data.
    Hepatology. 2020 Sep 6. doi: 10.1002/hep.31537.
    PubMed     Abstract available

    August 2020
  70. MERDRIGNAC A, Papoutsoglou P, Coulouarn C
    Long non-coding RNAs in cholangiocarcinoma.
    Hepatology. 2020 Aug 31. doi: 10.1002/hep.31534.
    PubMed     Abstract available

  71. LUO Y, Brigham D, Bednarek J, Torres R, et al
    Unique cholangiocyte-targeted IgM autoantibodies correlate with poor outcome in biliary atresia.
    Hepatology. 2020 Aug 7. doi: 10.1002/hep.31504.
    PubMed     Abstract available

  72. FRISSEN M, Liao L, Schneider KM, Djudjaj S, et al
    Bidirectional role of NLRP3 during acute and chronic cholestatic liver injury.
    Hepatology. 2020 Aug 4. doi: 10.1002/hep.31494.
    PubMed     Abstract available

  73. GINDIN Y, Chung C, Jiang Z, Zhou JZ, et al
    A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Novel Drivers of Disease Progression in Primary Sclerosing Cholangitis.
    Hepatology. 2020 Aug 3. doi: 10.1002/hep.31488.
    PubMed     Abstract available

  74. BAI X, Zhang H, Zhou Y, Nagaoka K, et al
    TET1 promotes malignant progression of cholangiocarcinoma with IDH1 wild-type.
    Hepatology. 2020 Aug 1. doi: 10.1002/hep.31486.
    PubMed     Abstract available

  75. WU N, Baiocchi L, Zhou T, Kennedy L, et al
    The Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury.
    Hepatology. 2020 Aug 1. doi: 10.1002/hep.31484.
    PubMed     Abstract available

    July 2020
  76. AMZAL R, Thebaut A, Lapalus M, Almes M, et al
    Pharmacological premature termination codon readthrough of ABCB11 in bile salt export pump deficiency: an in vitro study.
    Hepatology. 2020 Jul 23. doi: 10.1002/hep.31476.
    PubMed     Abstract available

  77. DU Y, Khandekar G, Llewellyn J, Polacheck W, et al
    Reply to letter to the editor: Comment on "a bile duct-on-a-chip with organ-level functions".
    Hepatology. 2020 Jul 21. doi: 10.1002/hep.31471.
    PubMed     Abstract available

  78. XIAO Y, Chen Q, Xu G, Mao Y, et al
    Letter to the editor: Comment on "a bile duct-on-a-chip with organ-level functions".
    Hepatology. 2020 Jul 20. doi: 10.1002/hep.31470.
    PubMed     Abstract available

  79. LLEO A, Ma X, Gershwin ME, Invernizzi P, et al
    Letter to the Editor: Might Denosumab Fit in Primary Biliary Cholangitis Treatment?
    Hepatology. 2020;72:359-360.

    June 2020
  80. VAN IJZENDOORN SCD, Li Q, Qiu YL, Wang JS, et al
    Unequal effects of MYO5B mutations in liver and intestine determine the clinical presentation of low-GGT cholestasis.
    Hepatology. 2020 Jun 24. doi: 10.1002/hep.31430.
    PubMed     Abstract available

  81. VARTAK N, Guenther G, Joly F, Damle-Vartak A, et al
    Intravital dynamic and correlative imaging reveals diffusion-dominated canalicular and flow-augmented ductular bile flux.
    Hepatology. 2020 Jun 19. doi: 10.1002/hep.31422.
    PubMed     Abstract available

  82. ABUD A, Maddur H, Salem R
    Management of symptomatic portal cavernoma cholangiopathy via transplenic portal vein recanalization and TIPS.
    Hepatology. 2020 Jun 5. doi: 10.1002/hep.31411.
    PubMed     Abstract available

  83. FABRIS L, Sato K, Alpini G, Strazzabosco M, et al
    The Tumor Microenvironment in Cholangiocarcinoma Progression.
    Hepatology. 2020 Jun 4. doi: 10.1002/hep.31410.
    PubMed     Abstract available

    May 2020
  84. DENEAU MR, Mack C, Perito ER, Ricciuto A, et al
    The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) index: a prognostic tool for children.
    Hepatology. 2020 May 28. doi: 10.1002/hep.31393.
    PubMed     Abstract available

  85. YAN C, Koda S, Wu J, Zhang BB, et al
    Roles of trained immunity in the pathogenesis of cholangiopathies: a novel therapeutic target.
    Hepatology. 2020 May 28. doi: 10.1002/hep.31395.
    PubMed     Abstract available

  86. GUNASEKARAN G, Bekki Y, Lourdusamy V, Schwartz M, et al
    Surgical Treatments of Hepatobiliary Cancers.
    Hepatology. 2020 May 21. doi: 10.1002/hep.31325.
    PubMed     Abstract available

  87. DEAN G, Hanauer S, Levitsky J
    The Role of the Intestine in the Pathogenesis of Primary Sclerosing Cholangitis: Evidence and Therapeutic Implications.
    Hepatology. 2020 May 11. doi: 10.1002/hep.31311.
    PubMed     Abstract available

  88. ZHANG Y, Wang H, Chen T, Wang H, et al
    C24 -Ceramide Drives Gallbladder Cancer Progression through Directly Targeting PIP4K2C to Facilitate mTOR Signaling Activation.
    Hepatology. 2020 May 6. doi: 10.1002/hep.31304.
    PubMed     Abstract available

    Blocking Sodum-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice.
    Hepatology. 2020 May 4. doi: 10.1002/hep.31292.
    PubMed     Abstract available

    April 2020
  90. CHEN J, Vitetta L
    Letter to the Editors: Could Butyrate Be Incorporated With Farnesoid X Receptor Agonist Cilofexor to Enhance Primary Sclerosing Cholangitis Treatment?
    Hepatology. 2020 Apr 23. doi: 10.1002/hep.31269.
    PubMed     Abstract available

  91. O'ROURKE CJ, Munoz-Garrido P, Andersen JB
    Molecular targets in cholangiocarcinoma.
    Hepatology. 2020 Apr 18. doi: 10.1002/hep.31278.
    PubMed     Abstract available

  92. TRAUNER M, Chung C, Myers RP, Kowdley KV, et al
    Reply to HEP-20-0140 Letter to the Editors: Could Butyrate Be Incorporated With Farnesoid X Receptor Agonist Cilofexor to Enhance Primary Sclerosing Cholangitis Treatment?
    Hepatology. 2020 Apr 12. doi: 10.1002/hep.31268.
    PubMed     Abstract available

  93. LARGHI A, Rimbas M, Ardito F, Rizzatti G, et al
    EUS-FNA for lymph nodes staging in cholangiocarcinoma: should it become standard of care?
    Hepatology. 2020 Apr 10. doi: 10.1002/hep.31266.
    PubMed     Abstract available

  94. ADAMS JM, Huppert KA, Castro EC, Lopez MF, et al
    Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome.
    Hepatology. 2020;71:1331-1349.
    PubMed     Abstract available

    March 2020
  95. RIMLAND CA, Tilson SG, Morell CM, Tomaz RA, et al
    Regional differences in human biliary tissues and corresponding in vitro derived organoids.
    Hepatology. 2020 Mar 29. doi: 10.1002/hep.31252.
    PubMed     Abstract available

  96. VATS R, Liu S, Zhu J, Mukhi D, et al
    Impaired bile secretion promotes hepatobiliary injury in Sickle Cell Disease.
    Hepatology. 2020 Mar 19. doi: 10.1002/hep.31239.
    PubMed     Abstract available

  97. ISAACS-TEN A, Echeandia M, Moreno-Gonzalez M, Brion A, et al
    Intestinal microbiome-macrophage crosstalk contributes to cholestatic liver disease by promoting intestinal permeability.
    Hepatology. 2020 Mar 13. doi: 10.1002/hep.31228.
    PubMed     Abstract available

  98. AZAD AI, Krishnan A, Troop L, Li Y, et al
    Targeted Apoptosis Of Ductular Reactive Cells Reduces Hepatic Fibrosis In A Mouse Model of Cholestasis.
    Hepatology. 2020 Mar 3. doi: 10.1002/hep.31211.
    PubMed     Abstract available

  99. LAVU S, Therneau TM, Harmsen WS, Mara KC, et al
    Effect of Statins on the Risk of Extrahepatic Cholangiocarcinoma.
    Hepatology. 2020 Mar 2. doi: 10.1002/hep.31146.
    PubMed     Abstract available

  100. LU ZN, Luo Q, Zhao LN, Shi Y, et al
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    Activation of a novel estrogen receptor GPR30 enhances cholesterol cholelithogenesis in female mice.
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    Insights into the origin of intrahepatic cholangiocarcinoma from mouse models.
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    Biomarkers for hepatobiliary cancers.
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  114. GAO E, Cheema H, Waheed N, Mushtaq I, et al
    OSTalpha deficiency: A disorder with cholestasis, liver fibrosis and congenital diarrhea.
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  115. LOZANO E, Asensio M, Perez-Silva L, Banales JM, et al
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  116. MALIKOWSKI T, Levy MJ, Gleeson FC, Storm AC, et al
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  117. SHUNG DL, Assis DN
    Machine Learning in a Complex Disease: PREsTo Improves The Prognostication of Primary Sclerosing Cholangitis.
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    Hepatology. 2019 Dec 13. doi: 10.1002/hep.31067.
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    November 2019
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    Liver Injury in Patients with Cholestatic Liver Disease Treated with Obeticholic Acid.
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    Biallelic mutations in TTC26 (IFT56) cause severe biliary ciliopathy in humans.
    Hepatology. 2019 Oct 8. doi: 10.1002/hep.30982.
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    September 2019
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    Probiotic LGG prevents liver fibrosis through inhibiting hepatic bile acid synthesis and enhancing bile acid excretion in mice.
    Hepatology. 2019 Sep 30. doi: 10.1002/hep.30975.
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    MicroRNA-210 promotes bile acid-induced cholestatic liver injury by targeting mixed-lineage leukemia-4 methyltransferase in mice.
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    Near infrared spectroscopy reveals brain hypoxia and cerebrovascular dysregulation in primary biliary cholangitis.
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    Hepatology Elsewhere.
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    Monoacylglycerol lipase inhibition protects from liver injury in mouse models of sclerosing cholangitis.
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    Wnt/beta-Catenin signaling plays a protective role in the Mdr2 KO murine model of cholestatic liver disease.
    Hepatology. 2019 Sep 6. doi: 10.1002/hep.30927.
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    A Bile Duct-on-a-Chip with Organ-Level Functions.
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    Timing of choledochal cyst perforation.
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    Rotavirus reassortant induced murine model of liver fibrosis parallels human biliary atresia.
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    Fatigue in Primary Biliary Cholangitis: no Place for Rituximab.
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    Peribiliary gland niche participates in biliary tree regeneration in mouse and in human primary sclerosing cholangitis.
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    mTORC1 Signaling is Required for the Dedifferentiation from Biliary Cell to Bi-potential Progenitor Cell in Zebrafish Liver Regeneration.
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    Prevention of cholestatic liver disease and reduced tumorigenicity in a murine model of PFIC type 3 using hybrid AAV-piggyBac gene therapy.
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    Fibrosing cholestatic hepatitis-like syndrome in an immunocompetent patient with an acute flare of chronic hepatitis B.
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    Causes of hOCT1-dependent cholangiocarcinoma resistance to sorafenib and sensitization by tumor-selective gene therapy.
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    Bile acid homeostasis in a Cyp7a1 & Cyp27a1 double knockout mouse model.
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    Genome Wide Association Studies of Specific Antinuclear Autoantibody Sub-phenotypes in Primary Biliary Cholangitis.
    Hepatology. 2019 Mar 10. doi: 10.1002/hep.30604.
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    February 2019
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    Soluble fibers improve metabolic syndrome but may cause liver disease and hepatocellular carcinoma.
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    Bezafibrate improves GLOBE and UK-PBC scores and long-term outcomes in patients with primary biliary cholangitis.
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    PROMININ-1 promotes biliary fibrosis associated with biliary atresia.
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    Hepatology Elsewhere.
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    Identification of PKD1L1 Gene Variants in Children with the Biliary Atresia Splenic Malformation Syndrome.
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    Effect of plasmapheresis on cholestatic pruritus and autotaxin activity during pregnancy.
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    Bile-derived organoids from patients with primary sclerosing cholangitis recapitulate their inflammatory immune profile.
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    Cholestatic drug induced liver injury caused by mifepristone.
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    Ageing-related expression of Twinfilin-1 regulates cholangiocyte biological response to injury.
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    Cirrhotic Cardiomyopathy in children with BA: A new objective parameter to predict morbidity and mortality on the waitlist - and beyond!
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    ID3 Promotes Stem Cell Features and Predicts Chemotherapeutic Response of Intrahepatic Cholangiocarcinoma.
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    Hepatic Autophagy Deficiency Compromises FXR Functionality and Causes Cholestatic Injury.
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    Cholangiocyte-to-Hepatocyte Differentiation: a Context Dependent Process and an Opportunity for Regenerative Medicine.
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    Bile Infarcts - new insights into the pathogenesis of obstructive cholestasis.
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    Hepatology. 2018 May 5. doi: 10.1002/hep.30078.

    April 2018
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    Fibroblast Growth Factor Receptor Inhibition for Cholangiocarcinoma: Looking through a Door Half-opened.
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    Plasma Bile Acid Concentrations in Humans: Suggestions for Presentation in Tabular Form.
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    Primary Biliary Cholangitis, DNA and Beyond: The Relative Contribution of Genes.
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    Gut-Liver Axis Alterations in Alcoholic Liver Disease: Are Bile Acids the Answer?
    Hepatology. 2017 Dec 22. doi: 10.1002/hep.29760.

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    The role of mEH, NTCP and OATP in hepatic sodium-dependent bile acid transport.
    Hepatology. 2017 Dec 6. doi: 10.1002/hep.29712.

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    Hepatology. 2017 Dec 1. doi: 10.1002/hep.29698.

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    Hepatology. 2017 Nov 16. doi: 10.1002/hep.29656.

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    Female preponderance of primary biliary cholangitis is all about our understanding of its autoimmune nature.
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    Ducts in a Dish: Bioengineered Biliary Scaffolds for Regenerative Medicine.
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    Novel beta-catenin/FXR Interaction Regulates Hepatic Bile Acid Metabolism During Cholestasis.
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    CFTR: Actin(g) as a master regulator of cholangiocyte function.
    Hepatology. 2017 Oct 10. doi: 10.1002/hep.29583.

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    Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis.
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    September 2017
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    Bile acids in NASH: pathophysiological driving force or innocent bystanders?
    Hepatology. 2017 Sep 19. doi: 10.1002/hep.29543.

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    Hepatology. 2017 Sep 16. doi: 10.1002/hep.29524.
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    Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies.
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    Intrahepatic cholangiocarcinoma arising from HBV Infection may be a highly selected population for liver transplantation.
    Hepatology. 2017 Jul 31. doi: 10.1002/hep.29413.

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    Hepatology. 2017 Jul 24. doi: 10.1002/hep.29400.
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    The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids.
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    Role of ErbB/HER family of receptor tyrosine kinases in cholangiocyte biology.
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    June 2017
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    Transintestinal cholesterol excretion (TICE): A secondary, non-biliary pathway contributing to reverse cholesterol transport.
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    Hepatic bile acid uptake in humans and mice: Multiple pathways and expanding potential role for gut-liver signaling.
    Hepatology. 2017 Jun 23. doi: 10.1002/hep.29325.

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    The challenge of cholangiocarcinoma diagnosis: the turning point is in extracellular vesicles?
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    Treg Conditioning Endows Activated Teff with Suppressor Function in Autoimmune Hepatitis/Autoimmune Sclerosing Cholangitis.
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    aPKC-iota/P-Sp1/Snail signaling induces epithelial-mesenchymal transition and immunosuppression in cholangiocarcinoma.
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    May 2017
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    Linking long non-coding RNA to control bile acid signaling and cholestatic liver fibrosis.
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    Autoreactive Monoclonal Antibodies from Patients with Primary Biliary Cholangitis Recognize Environmental Xenobiotics.
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    Primary biliary cholangitis: Treatment options finally expand.
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    February 2017
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    Idiosyncratic drug-induced liver injury associated with bile duct loss and vanishing bile duct syndrome: Rare but has severe consequences.
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    December 2016
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    Dual role of the bile acid receptor TGR5 for hepatic lipid metabolism in feast and famine.
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    Aspirin for cholangiocarcinoma prevention: new targets to shift the dogma from ascertained risk to possible prevention (Reply to: Risk Factors for Cholangiocarcinoma: Aspirin-use and the Risk of Cholangiocarcinoma).
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    Strategies to improve survival of patients with intrahepatic cholangiocarcinoma undergoing liver transplantation.
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