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  Biliary Tract Diseases

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Articles published in PLoS One

Retrieve available abstracts of 85 articles:
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Single Articles


    January 2026
  1. BAGULEY E, Knaub M, VanDyke J, Hirschfield G, et al
    Evaluating the clinical care, quality of life and overall experiences of patients with primary biliary cholangitis (PBC) during the pandemic: A Canadian mixed-methods study.
    PLoS One. 2026;21:e0340475.
    PubMed     Abstract available


  2. ZHANG C, Liang H, Qin Y, Tan X, et al
    A cost-effectiveness analysis comparing pembrolizumab combined with chemotherapy versus chemotherapy alone for advanced biliary tract cancer: US and China perspectives.
    PLoS One. 2026;21:e0341154.
    PubMed     Abstract available


  3. PARK Y, Kim KS, Jo H, Kim HP, et al
    Feasibility of tumor-informed circulating tumor DNA for detecting minimal residual disease in surgically resected biliary tract cancer.
    PLoS One. 2026;21:e0341432.
    PubMed     Abstract available


  4. CHUEAJEDTON K, Chueaiphuk C, Inpad J, Kumphune S, et al
    Secretory leukocyte protease inhibitor (SLPI) promotes cholangiocarcinoma progression via inflammation-associated and vasculogenic mechanisms.
    PLoS One. 2026;21:e0340763.
    PubMed     Abstract available


  5. FABIAN O, Bajer L, Macinga P, Brezina J, et al
    Identifying biomarkers for diagnosis and disease activity monitoring in PSC-IBD and UC through proteomic profiling: A prospective, biomarker discovery single-center study protocol.
    PLoS One. 2026;21:e0341885.
    PubMed     Abstract available


  6. KITAGATAYA T, Krishnan A, Olson KE, Gutierrez F, et al
    Genetic ablation of interleukin-17A augments fibrosis in a mouse model of cholestatic liver injury.
    PLoS One. 2026;21:e0342251.
    PubMed     Abstract available


  7. CHEN R, Sun Y, Tai W
    A multifaceted analysis of OTUD5 integrated MAVS in innate immunity of Primary Biliary Cholangitis.
    PLoS One. 2026;21:e0342306.
    PubMed     Abstract available


  8. XI J, Wang S, Chen J, Law JCS, et al
    Exploration and discovery of treatment targets for primary biliary cholangitis based on plasma and cerebrospinal fluid proteomics: A multicenter mendelian randomization study.
    PLoS One. 2026;21:e0340166.
    PubMed     Abstract available


  9. ARTBUA P, Kentachalee N, Sitthirak S, Sa-Ngiamwibool P, et al
    Prognostic value of cGAS-STING-IRF3 signaling in cholangiocarcinoma patients.
    PLoS One. 2026;21:e0342756.
    PubMed     Abstract available


    January 2025
  10. SUGAWARA I, Kawahara Y, Takayasu L, Isshi K, et al
    Study on the relationship between microbial composition within obstructive biliary stents and the severity of obstruction and duration of stent placement.
    PLoS One. 2025;20:e0317230.
    PubMed     Abstract available


  11. SAWAYA M, Cordina-Duverger E, Lamy PJ, Tretarre B, et al
    Kidney and gallbladder stones and the risk of prostate cancer: Results from the EPICAP study.
    PLoS One. 2025;20:e0317760.
    PubMed     Abstract available


  12. ARMARTMUNTREE N, Kittirat Y, Promraksa B, Loilome W, et al
    Antioxidative and anticancer effects of Tacca chantrieri extract enhancing cisplatin sensitivity in cholangiocarcinoma cells.
    PLoS One. 2025;20:e0317111.
    PubMed     Abstract available


  13. THAKUR C, Mahato RK, Marasini S, Timalsena D, et al
    Risk factors of gallbladder cancer in Nepal: A case control study.
    PLoS One. 2025;20:e0317249.
    PubMed     Abstract available


  14. WANG F, Gao Y
    Efficacy of early enteral nutrition support on the nutritional status of patients after gallstone surgery.
    PLoS One. 2025;20:e0314659.
    PubMed     Abstract available


  15. HASAN R, Allahbakhshi F, Shlyk AD, Allahbakhshi K, et al
    Gallstones as a predictor of elevated cardiovascular disease risk: A meta-analysis and meta-regression of over 7.4 million participants.
    PLoS One. 2025;20:e0314661.
    PubMed     Abstract available


  16. ABUBAKR K, Kennedy C, Al-Tikriti S, O'Higgins AC, et al
    Intrahepatic cholestasis of pregnancy and gestational diabetes: Protocol for a scoping review of associations, risk factors, and outcomes.
    PLoS One. 2025;20:e0300076.
    PubMed     Abstract available


  17. GAO C, Liu M, Sun Y, Zhao Z, et al
    Association between advanced lung cancer inflammation index and gallstone prevalence among U.S. adults: A population-based study.
    PLoS One. 2025;20:e0321733.
    PubMed     Abstract available


  18. TIAN L, Guo Q, Fu D, Ma X, et al
    Adjuvant chemotherapy compared with observation in patients with resected biliary tract cancer: A systematic review and meta-analysis of randomized controlled trials.
    PLoS One. 2025;20:e0295583.
    PubMed     Abstract available


  19. SAEHENG T, Tongsiri N, Na-Bangchang K
    The first validation of the Functional Assessment of Cancer Therapy Hepatobiliary (FACT-Hep) for evaluating health-related quality of life (HRQOL) in patients with advanced-stage intrahepatic cholangiocarcinoma (biliary tract cancer).
    PLoS One. 2025;20:e0321618.
    PubMed     Abstract available


  20. YE J, Liu R, Wang J, Ma W, et al
    Association of albumin-bilirubin grade with survival outcomes in patients with cholangiocarcinoma.
    PLoS One. 2025;20:e0321758.
    PubMed     Abstract available


  21. THANYAPHOO S, Sae-Lee C, Thaopech W, Amornrit W, et al
    Transcriptome insights into newcastle disease virus-mediated eradication of cholangiocarcinoma cells.
    PLoS One. 2025;20:e0322307.
    PubMed     Abstract available


  22. WIN ZZ, Dokduang H, Kulwong S, Loilome W, et al
    Characterization and identification of extrachromosomal circular DNA in cholangiocarcinoma.
    PLoS One. 2025;20:e0322173.
    PubMed     Abstract available


  23. OLFATIFAR M, Rajabnia M, Sadeghi A, Rabbani A, et al
    The epidemiological trends and projected future of primary sclerosing cholangitis by 2040: An updated meta-analysis and modeling study.
    PLoS One. 2025;20:e0322479.
    PubMed     Abstract available


  24. MARTVISET P, Chantree P, Tongsiri N, Plengsuriyakarn T, et al
    Targeting tumor-associated genes, immune response, and circulating tumor cells in intrahepatic cholangiocarcinoma: Therapeutic potential of Atractylodes lancea (Thunb.) DC.
    PLoS One. 2025;20:e0323732.
    PubMed     Abstract available


  25. INOUE T, Masuda T, Koiso T, Ibusuki M, et al
    Heated-balloon ablation as a novel less invasive local treatment for bile duct strictures: A first experimental study.
    PLoS One. 2025;20:e0322801.
    PubMed     Abstract available


  26. NGAMSANGIAM W, Techa-Ay S, Sa-Ngiamwibool P, Watcharadetwittaya S, et al
    Distinct chromosome abnormality patterns for differential diagnosis of hepatocellular carcinoma and cholangiocarcinoma.
    PLoS One. 2025;20:e0322408.
    PubMed     Abstract available


  27. NOGUCHI D, Kuriyama N, Kozuka Y, Komatubara H, et al
    A recent update on the morphological classification of intraductal papillary neoplasm of the bile duct: Correlation with postoperative prognosis and pathological features.
    PLoS One. 2025;20:e0325081.
    PubMed     Abstract available


  28. SCHACHTSCHNEIDER KM, Redlon LN, Lokken RP, Huang YH, et al
    Epigenetic regulation of individual components of combined hepatocellular-cholangiocarcinoma.
    PLoS One. 2025;20:e0324145.
    PubMed     Abstract available


  29. FAIPAN A, Sitthirak S, Wangwiwatsin A, Namwat N, et al
    Mitochondrial genomic alterations in cholangiocarcinoma cell lines.
    PLoS One. 2025;20:e0323844.
    PubMed     Abstract available


  30. XIONG Z, Sun Q, Huang J, Li F, et al
    Non-linear association of cardiometabolic index with gallstone disease in US adults: A cross-sectional study.
    PLoS One. 2025;20:e0328415.
    PubMed     Abstract available


  31. WANG J, Qi X, Zhao W, Hao Z, et al
    Hsa_circ_0006834 represses intrahepatic cholangiocarcinoma proliferation through activating AMPK-mTOR pathway and autophagy via has-miR-637-NGFR network.
    PLoS One. 2025;20:e0329847.
    PubMed     Abstract available


  32. CHEN X, Huang J, Chen X, Luo Q, et al
    Comparative analysis of differences for pathological upgrade and incomplete resection in endoscopic snare papillectomy for ampullary adenomas: A single-institution retrospective study.
    PLoS One. 2025;20:e0330220.
    PubMed     Abstract available


  33. SHEN W, Liu Y, Dai B, Qin C, et al
    Downregulation of NCOA4 expression indicates poor prognosis and promotes the progression of cholangiocarcinoma.
    PLoS One. 2025;20:e0327722.
    PubMed     Abstract available


  34. LYU C, Meng X, Wang J, Shao H, et al
    Optimized processing of Gardenia Fruits with ginger juice: Unveiling therapeutic mechanisms for cholestatic liver injury through TLR4/NF-kappaB, FXR/PPAR-alpha, and PI3K/AKT/GSK-3beta.
    PLoS One. 2025;20:e0330189.
    PubMed     Abstract available


  35. LI J, Zhou YQ
    Enhanced gallbladder cancer detection via active and self-supervised learning integration: Innovating B-ultrasound image analysis.
    PLoS One. 2025;20:e0330781.
    PubMed     Abstract available


  36. DU C, Wang H, Cao W, Yu Z, et al
    Perioperative and long-term outcomes of laparoscopic liver resection for combined hepatocellular carcinoma and cholangiocarcinoma versus intrahepatic cholangiocarcinoma: A propensity score matching analysis.
    PLoS One. 2025;20:e0328104.
    PubMed     Abstract available


  37. MON AM, Intuyod K, Klungsaeng S, Jusakul A, et al
    A circulating microRNA panel enhances the diagnosis of cholangiocarcinoma.
    PLoS One. 2025;20:e0333279.
    PubMed     Abstract available


  38. TANASUKA P, Thongpon P, Chomwong S, Kongsintaweesuk S, et al
    Suppression of kinesin family member-18A diminishes progression and induces apoptotic cell death of gemcitabine-resistant cholangiocarcinoma cells by modulating PI3K/Akt/mTOR and NF-kappaB pathways.
    PLoS One. 2025;20:e0334147.
    PubMed     Abstract available


  39. SERRI R, Dehneh N, Ghannam M, Sirri MR, et al
    Synergistic effects of sesame oil, extra virgin olive oil, psyllium extract, and dandelion extract on cholesterol gallstone dissolution: An in vitro comparative study against Rowachol(R).
    PLoS One. 2025;20:e0334496.
    PubMed     Abstract available


  40. CHAIDEE A, Kongsintaweesuk S, Pongking T, Tunbenjasiri K, et al
    Minimally invasive detection of early-stage opisthorchiasis-associated cholangiocarcinoma using label-free surface-enhanced Raman spectroscopy (SERS) of hamster serum.
    PLoS One. 2025;20:e0334916.
    PubMed     Abstract available


  41. DAI J, Selvaraj E, Culver EL, Bailey A, et al
    Association between non-invasive biomarkers and quality of life in Primary Sclerosing Cholangitis.
    PLoS One. 2025;20:e0335642.
    PubMed     Abstract available


  42. HEINRICH S, Ten Thoren PJ, Behrendt P, Hagenah J, et al
    Dynamic growth risk of incidentally detected gallbladder polyps-A retrospective, single-center analysis.
    PLoS One. 2025;20:e0337890.
    PubMed     Abstract available


    January 2024
  43. LIU Z, Shao Y, Duan X
    Genetic link between primary biliary cholangitis and connective tissue diseases in European populations: A two-sample Mendelian randomization study.
    PLoS One. 2024;19:e0298225.
    PubMed     Abstract available


  44. DI CARLO P, Serra N, Fasciana TMA, Giammanco A, et al
    Microbial profile in bile from pancreatic and extra-pancreatic biliary tract cancer.
    PLoS One. 2024;19:e0294049.
    PubMed     Abstract available


  45. BAGER P, Bossen L, Gantzel R, Gronbaek H, et al
    High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial.
    PLoS One. 2024;19:e0301354.
    PubMed     Abstract available


  46. GUPTA K, Xu JP, Diamond T, de Jong IEM, et al
    Low-dose biliatresone treatment of pregnant mice causes subclinical biliary disease in their offspring: Evidence for a spectrum of neonatal injury.
    PLoS One. 2024;19:e0301824.
    PubMed     Abstract available


  47. BEKRIC D, Kiesslich T, Ocker M, Winklmayr M, et al
    The efficacy of ferroptosis-inducing compounds IKE and RSL3 correlates with the expression of ferroptotic pathway regulators CD71 and SLC7A11 in biliary tract cancer cells.
    PLoS One. 2024;19:e0302050.
    PubMed     Abstract available


  48. ZHOU X, Huang T, Pan H, Du A, et al
    Bioinformatics and system biology approaches to determine the connection of SARS-CoV-2 infection and intrahepatic cholangiocarcinoma.
    PLoS One. 2024;19:e0300441.
    PubMed     Abstract available


  49. KIM SH, Lee S
    Determining the patency of biliary tracts in dogs with gallbladder mucocele using near-infrared cholangiography with indocyanine green.
    PLoS One. 2024;19:e0300395.
    PubMed     Abstract available


  50. HUANG X, Gu H, Shen P, Zhang X, et al
    Systematic review and meta-analysis: Evaluating the influence of intrahepatic cholestasis of pregnancy on obstetric and neonatal outcomes.
    PLoS One. 2024;19:e0304604.
    PubMed     Abstract available


  51. ALI K, Chervu NL, Sakowitz S, Bakhtiyar SS, et al
    Interhospital variation in the nonoperative management of acute cholecystitis.
    PLoS One. 2024;19:e0300851.
    PubMed     Abstract available


  52. GOOKIN JL, Jewell DE, Aicher KM, Seiler GS, et al
    Increased lipogenesis and lipidosis of gallbladder epithelium in dogs with gallbladder mucocele formation.
    PLoS One. 2024;19:e0303191.
    PubMed     Abstract available


  53. KERDKUMTHONG K, Nanarong S, Roytrakul S, Pitakpornpreecha T, et al
    Quantitative proteomics analysis reveals possible anticancer mechanisms of 5'-deoxy-5'-methylthioadenosine in cholangiocarcinoma cells.
    PLoS One. 2024;19:e0306060.
    PubMed     Abstract available


  54. LI L, Liu C, Xia T, Li H, et al
    Association between plant-based dietary index and gallstone disease: A cross sectional study from NHANES.
    PLoS One. 2024;19:e0305822.
    PubMed     Abstract available


  55. TANG G, Nierath WF, Leitner E, Xie W, et al
    Comparing animal well-being between bile duct ligation models.
    PLoS One. 2024;19:e0303786.
    PubMed     Abstract available


  56. MANTAS A, Otto CC, Olthof PB, Heise D, et al
    Clinical features and prediction of long-term survival after surgery for perihilar cholangiocarcinoma.
    PLoS One. 2024;19:e0304838.
    PubMed     Abstract available


  57. HAN X, Wang J, Wu Y, Gu H, et al
    Predictive value of bile acids as metabolite biomarkers for gallstone disease: A systematic review and meta-analysis.
    PLoS One. 2024;19:e0305170.
    PubMed     Abstract available


  58. KATSUMI T, Sato H, Murakami R, Hanatani T, et al
    Identification of microbial antigens in liver tissues involved in the pathogenesis of primary biliary cholangitis using 16S rRNA metagenome analysis.
    PLoS One. 2024;19:e0308912.
    PubMed     Abstract available


  59. GOPAL SH, Zebda R, Mohan A, Borovsky K, et al
    Population-based screening strategies for biliary atresia in the newborn: A systematic review and meta-analysis.
    PLoS One. 2024;19:e0307837.
    PubMed     Abstract available


  60. WATAD H, Ohayon A, Meyer R, Cohen A, et al
    Proteinuria is a clinical characteristic of intrahepatic cholestasis of pregnancy but it is not a marker of severity: A retrospective cohort study.
    PLoS One. 2024;19:e0310217.
    PubMed     Abstract available


  61. PANYA A, Wathikthinnakon M, Thepmalee C, Chiawpanit C, et al
    Polysaccharide extract of Spirulina sp. increases effector immune-cell killing activities against cholangiocarcinoma.
    PLoS One. 2024;19:e0312414.
    PubMed     Abstract available


  62. WANG T, Xie R, Jiang C, Chen L, et al
    Associations between Life's Essential 8 and gallstones among US adults: A cross-sectional study from NHANES 2017-2018.
    PLoS One. 2024;19:e0312857.
    PubMed     Abstract available


  63. LI X, Wang J, Leng K
    Lipid accumulation product and gallstone risk in US adults: A cross-sectional analysis of NHANES 2017-2020 data.
    PLoS One. 2024;19:e0315235.
    PubMed     Abstract available


  64. YU S, Kang M, Yoo Y, Kim TY, et al
    Characterization of an Enterococcus sp. SMC-9 strain isolated from bile of a patient with cholangitis.
    PLoS One. 2024;19:e0312953.
    PubMed     Abstract available


  65. ANGENDOHR C, Missing L, Ehlting C, Wolf SD, et al
    Interleukin 1 beta suppresses bile acid-induced BSEP expression via a CXCR2-dependent feedback mechanism.
    PLoS One. 2024;19:e0315243.
    PubMed     Abstract available


  66. SAHAT O, Kamsa-Ard S, Suwannatrai AT, Lim A, et al
    Spatial analysis of cholangiocarcinoma in Thailand from 2012 to 2021; a population-based cancer registries study.
    PLoS One. 2024;19:e0311035.
    PubMed     Abstract available


    January 2023
  67. ZHOU T, Wei H, Wang J
    Research experimental design for the construction and identification of the pGEX-BCKD-E4A recombinant point-mutant plasmid.
    PLoS One. 2023;18:e0279431.
    PubMed     Abstract available


  68. WONGKANONG C, Patumanond J, Ratanachu-Ek T, Junrungsee S, et al
    Development of clinical prediction rule for the requirement of endoscopic papillary large balloon dilation (EPLBD) on endoscopic CBD stone clearance.
    PLoS One. 2023;18:e0282899.
    PubMed     Abstract available


  69. INOUE T, Kutsumi H, Ibusuki M, Yoneda M, et al
    Endoscopic biliary ethanol ablation using a novel multi-hole balloon catheter: In vivo feasibility study in a swine model.
    PLoS One. 2023;18:e0283733.
    PubMed     Abstract available


  70. YANG S, Qin L, Wu P, Liu Y, et al
    RNA sequencing revealed the multi-stage transcriptome transformations during the development of gallbladder cancer associated with chronic inflammation.
    PLoS One. 2023;18:e0283770.
    PubMed     Abstract available


  71. YE Y, Lui VCH, Babu RO, Wu Z, et al
    Identification of cancer-related genes FGFR2 and CEBPB in choledochal cyst via RNA sequencing of patient-derived liver organoids.
    PLoS One. 2023;18:e0283737.
    PubMed     Abstract available


  72. HAN X, Wang J, Wu Y, Gu H, et al
    Predictive value of bile acids as metabolite biomarkers for gallstones: A protocol of systematic review and meta-analysis.
    PLoS One. 2023;18:e0284138.
    PubMed     Abstract available


  73. POUDEL SK, Padmanabhan R, Dave H, Guinta K, et al
    Microbiomic profiles of bile in patients with benign and malignant pancreaticobiliary disease.
    PLoS One. 2023;18:e0283021.
    PubMed     Abstract available


  74. JANNONE G, de Magnee C, Tambucci R, Evraerts J, et al
    Premature senescence of the liver in Alagille patients.
    PLoS One. 2023;18:e0285019.
    PubMed     Abstract available


  75. KIM MH, Lee EJ, Kim SJ, Jung YJ, et al
    Macrophage inhibitory cytokine-1 aggravates diet-induced gallstone formation via increased ABCG5/ABCG8 expression.
    PLoS One. 2023;18:e0287146.
    PubMed     Abstract available


  76. SIDDIQUI MA, Dwivedi N, Siddiqui MH, Rana SV, et al
    NMR spectroscopy-based analysis of gallstones of cancerous and benign gallbladders from different geographical regions of the Indian subcontinent.
    PLoS One. 2023;18:e0286979.
    PubMed     Abstract available


  77. MAYR C, Kiesslich T, Bekric D, Beyreis M, et al
    Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells.
    PLoS One. 2023;18:e0287769.
    PubMed     Abstract available


  78. NEROLDOVA M, Ciara E, Slatinska J, Frankova S, et al
    Exome sequencing reveals IFT172 variants in patients with non-syndromic cholestatic liver disease.
    PLoS One. 2023;18:e0288907.
    PubMed     Abstract available


  79. KUNIYOSHI N, Imazu H, Masuzaki R, Yamazaki M, et al
    Diagnostic utility of quantitative analysis of microRNA in bile samples obtained during endoscopic retrograde cholangiopancreatography for malignant biliary strictures.
    PLoS One. 2023;18:e0289537.
    PubMed     Abstract available


  80. IWAMOTO T, Suda T, Inoue T, Nozaki Y, et al
    Postoperative bleeding after percutaneous transhepatic gallbladder drainage and aspiration in patients receiving antithrombotic therapy.
    PLoS One. 2023;18:e0288463.
    PubMed     Abstract available


  81. SHEARN CT, Anderson AL, Devereaux MW, El Kasmi KC, et al
    Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition.
    PLoS One. 2023;18:e0290385.
    PubMed     Abstract available


  82. GOINS EC, Wein LE, Watkins VY, Campbell AIK, et al
    Maternal and neonatal outcomes in patients with hepatitis C and intrahepatic cholestasis of pregnancy: The sum of the parts.
    PLoS One. 2023;18:e0293030.
    PubMed     Abstract available


  83. PHAM HN, Pham L, Sato K
    Bioinformatic analysis identified novel candidate genes with the potentials for diagnostic blood testing of primary biliary cholangitis.
    PLoS One. 2023;18:e0292998.
    PubMed     Abstract available


  84. HAYASHI H, Shimizu A, Kubota K, Notake T, et al
    Impact of sarcopenic obesity on post-hepatectomy bile leakage for hepatocellular carcinoma.
    PLoS One. 2023;18:e0286353.
    PubMed     Abstract available


  85. YUK JS, Park JY
    Menopausal hormone therapy increases the risk of gallstones: Health Insurance Database in South Korea (HISK)-based cohort study.
    PLoS One. 2023;18:e0294356.
    PubMed     Abstract available


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