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  Ischemic Heart Disease

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Articles published in Ann Intern Med

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Single Articles


    December 2025
  1. STEEN JP, Klatt KC, Chang Y, Guyatt GH, et al
    Effect of Interventions Aimed at Reducing or Modifying Saturated Fat Intake on Cholesterol, Mortality, and Major Cardiovascular Events : A Risk Stratified Systematic Review of Randomized Trials.
    Ann Intern Med. 2025 Dec 16. doi: 10.7326/ANNALS-25-02229.
    PubMed     Abstract available


  2. ESTRUCH R, Lamuela-Raventos RM
    Saturated Fats and Cardiovascular Disease: From Avoidance to a Nuanced Recommendation.
    Ann Intern Med. 2025 Dec 16. doi: 10.7326/ANNALS-25-04971.
    PubMed    



  3. Annals Video Summary - Effect of Interventions Aimed at Reducing or Modifying Saturated Fat Intake on Cholesterol, Mortality, and Major Cardiovascular Events.
    Ann Intern Med. 2025 Dec 16:e2504737VS. doi: 10.7326/ANNALS-25-04737.
    PubMed    



  4. Correction: Chronic Coronary Artery Disease.
    Ann Intern Med. 2025 Dec 9. doi: 10.7326/ANNALS-25-05126.
    PubMed    


  5. MEI DA, Romiti GF
    In patients with chronic coronary syndrome and high atherothrombotic risk, adding aspirin to OAC increased adverse CV events at 2 y.
    Ann Intern Med. 2025 Dec 2. doi: 10.7326/ANNALS-25-04685.
    PubMed     Abstract available


  6. LEIVA O, Elgendy IY
    In adults with MI and LVEF >40% after invasive care, beta-blocker therapy did not reduce a composite adverse outcome at a median 3.7 y.
    Ann Intern Med. 2025;178:JC134.
    PubMed     Abstract available


  7. LEIVA O, Elgendy IY
    In adults with MI and LVEF >/=40%, beta-blocker therapy reduced a composite adverse outcome at a median 3.5 y.
    Ann Intern Med. 2025;178:JC135.
    PubMed     Abstract available


  8. BATES ER
    P2Y12 inhibitor monotherapy soon after PCI for ACS was not noninferior to DAPT for a composite of death or ischemic events.
    Ann Intern Med. 2025;178:JC137.
    PubMed     Abstract available


  9. BATES ER
    After successful PCI for AMI and 1 mo of DAPT, P2Y12 inhibitor monotherapy was noninferior to continued DAPT for adverse outcomes.
    Ann Intern Med. 2025;178:JC136.
    PubMed     Abstract available


  10. LIM LS
    In healthy older adults, low-dose aspirin for a median 4.7 y did not reduce MACE but increased major hemorrhage at a median 8.3 y.
    Ann Intern Med. 2025;178:JC139.
    PubMed     Abstract available


    November 2025

  11. Correction: Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults.
    Ann Intern Med. 2025 Nov 25. doi: 10.7326/ANNALS-25-04990.
    PubMed    


  12. HEERSPINK HJL, Grams ME, Sang Y, Ballew SH, et al
    Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk : An Individual Patient-Level Meta-analysis.
    Ann Intern Med. 2025 Nov 4. doi: 10.7326/ANNALS-25-02117.
    PubMed     Abstract available


    October 2025
  13. DEL POZO CRUZ B, Ahmadi M, Sabag A, Saint Maurice PF, et al
    Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults.
    Ann Intern Med. 2025 Oct 28. doi: 10.7326/ANNALS-25-01547.
    PubMed     Abstract available


  14. KITTLESON MM
    Chronic Coronary Artery Disease.
    Ann Intern Med. 2025 Oct 14. doi: 10.7326/ANNALS-25-03512.
    PubMed     Abstract available


    September 2025
  15. FIELD TS
    In AIS due to LVO presenting within 4.5 h of onset, adding tenecteplase to EVT increased functional independence at 90 d.
    Ann Intern Med. 2025 Sep 2. doi: 10.7326/ANNALS-25-03337.
    PubMed     Abstract available


    August 2025
  16. PAGANO MB, Stanworth SJ, Dennis J, Bakhtary S, et al
    Red Cell Transfusion in Acute Myocardial Infarction: AABB International Clinical Practice Guidelines.
    Ann Intern Med. 2025 Aug 19. doi: 10.7326/ANNALS-25-00706.
    PubMed     Abstract available


  17. OGUNTALA JO, Yan AT
    Toward Evidence-Based Transfusion for Anemia in Acute Myocardial Infarction: Still an Unfinished Story.
    Ann Intern Med. 2025 Aug 19. doi: 10.7326/ANNALS-25-02486.
    PubMed    


  18. CENTOR RM, Kip K, Saeed A
    Web Exclusive. Annals On Call - Semaglutide Versus Dulaglutide or Empagliflozin: Death and Cardiovascular Outcomes for Patients With Type 2 Diabetes.
    Ann Intern Med. 2025;178:e2503594OC.
    PubMed    


    July 2025
  19. AGGARWAL R, Wadhera RK, Chiu N, Szarek M, et al
    Cardiovascular Risk Factor and Disease Mortality Among Asian Indian, Chinese, and Filipino Adults in the United States, 2018 to 2023.
    Ann Intern Med. 2025 Jul 29. doi: 10.7326/ANNALS-25-00108.
    PubMed    


  20. SHAHID M, Gandhi GY
    In patients with diabetes and previous MI, high-dose multivitamins and minerals did not reduce CV events.
    Ann Intern Med. 2025 Jul 1. doi: 10.7326/ANNALS-25-02174.
    PubMed     Abstract available


    June 2025
  21. SAEED A, Mulukutla SR, Thoma F, Lemon L, et al
    Comparison of Semaglutide or Dulaglutide Versus Empagliflozin for Risk for Death and Cardiovascular Outcomes Among Patients With Type 2 Diabetes : Two Target Trial Emulation Studies.
    Ann Intern Med. 2025 Jun 17. doi: 10.7326/ANNALS-24-00775.
    PubMed     Abstract available



  22. Summary for Patients: Semaglutide or Dulaglutide Versus Empagliflozin for Risk for Death and Cardiovascular Outcomes Among Patients With Type 2 Diabetes.
    Ann Intern Med. 2025 Jun 17. doi: 10.7326/ANNALS-24-00775.
    PubMed    


  23. BATUR P
    Some combined and progestin-only contraceptives were linked to increased risk for ischemic stroke and myocardial infarction.
    Ann Intern Med. 2025 Jun 3. doi: 10.7326/ANNALS-25-01774.
    PubMed     Abstract available


  24. OGUNTALA JO, Yan AT
    In AF with stable CAD, an OAC alone does not increase ischemic events and reduces major bleeding vs. OAC + SAPT at a mean 22 mo.
    Ann Intern Med. 2025;178:JC65.
    PubMed     Abstract available


  25. DUNN AS
    In ACS with DES, de-escalating DAPT to ticagrelor alone vs. standard DAPT reduces major bleeding without increasing ischemic events.
    Ann Intern Med. 2025;178:JC66.
    PubMed     Abstract available


  26. AU YEUNG SL, Luo S, Schooling CM
    Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men.
    Ann Intern Med. 2025;178:905.
    PubMed    


  27. SELINGER S
    Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men.
    Ann Intern Med. 2025;178:904-905.
    PubMed    


  28. LIN YH, Lin KJ, Chen JY, Juang HH, et al
    Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men.
    Ann Intern Med. 2025;178:905-906.
    PubMed    


  29. YEAP BB, Wittert GA, Wu FCW, Vanderschueren D, et al
    Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men.
    Ann Intern Med. 2025;178:906-907.
    PubMed    


    May 2025
  30. MANSOOR H, Elgendy IY
    In AF with recent ACS or PCI, apixaban reduced total bleeding vs. VKA; aspirin increased total bleeding vs. placebo at 6 mo.
    Ann Intern Med. 2025;178:JC57.
    PubMed     Abstract available


  31. KHATTAK S, Al-Ansari A, Alfaraidhy M, Rajah F, et al
    Cardiology: What You May Have Missed in 2024.
    Ann Intern Med. 2025;178.
    PubMed     Abstract available


    April 2025
  32. CIACCI P, Romiti GF, Corica B
    In older adults with severe AS and complex CAD, PCI + TAVI vs. SAVR + CABG reduced patient-oriented outcomes at 1 y.
    Ann Intern Med. 2025;178:JC45.
    PubMed     Abstract available


    March 2025
  33. NTSEKHE M
    Low Prevalence of Coronary Artery Disease Among Ugandans With and Without HIV: Local Anomaly or Regional Reality?
    Ann Intern Med. 2025 Mar 12. doi: 10.7326/ANNALS-24-03940.
    PubMed    


  34. SIEDNER MJ, Ghoshhajra B, Erem G, Nassanga R, et al
    Epidemiology of Coronary Atherosclerosis Among People Living With HIV in Uganda : A Cross-Sectional Study.
    Ann Intern Med. 2025 Mar 12. doi: 10.7326/ANNALS-24-02233.
    PubMed     Abstract available


  35. LADER EW
    In previous MI with ventricular tachycardia (VT), catheter ablation reduced mortality or VT events more than antiarrhythmic drug therapy at 4 y.
    Ann Intern Med. 2025 Mar 4. doi: 10.7326/ANNALS-25-00336.
    PubMed     Abstract available


  36. OGUNTALA JO, Yan AT
    In acute MI and acute or chronic anemia, liberal vs. restrictive transfusion did not affect recurrent MI or death.
    Ann Intern Med. 2025 Mar 4. doi: 10.7326/ANNALS-25-00161.
    PubMed     Abstract available


  37. KELSEY MD, Newby LK
    In patients with acute MI, spironolactone did not reduce cardiac events at 3 y.
    Ann Intern Med. 2025;178:JC33.
    PubMed     Abstract available


  38. KELSEY MD, Newby LK
    In patients with acute MI, colchicine did not reduce cardiac events at 3 y.
    Ann Intern Med. 2025;178:JC32.
    PubMed     Abstract available


    February 2025
  39. LEE YJ, Gao X, Lee SH, Kan J, et al
    De-escalating Dual Antiplatelet Therapy to Ticagrelor Monotherapy in Acute Coronary Syndrome : A Systemic Review and Individual Patient Data Meta-Analysis of Randomized Clinical Trials.
    Ann Intern Med. 2025 Feb 18. doi: 10.7326/ANNALS-24-03102.
    PubMed     Abstract available



  40. Annals Video Summary - De-escalating Dual Antiplatelet Therapy to Ticagrelor Monotherapy in Acute Coronary Syndrome.
    Ann Intern Med. 2025 Feb 18:e2500013VS. doi: 10.7326/ANNALS-25-00013.
    PubMed    


  41. WEITZ HH, Merli GJ
    Web Exclusive. Annals Consult Guys - Care of Patients With Low Cardiac Risk but Incidental Coronary Artery Calcification.
    Ann Intern Med. 2025;178:e2500667CG.
    PubMed    


    January 2025
  42. MASUDA S, Fukasawa T, Matsuda S, Kawakami K, et al
    Cardiovascular Safety and Fracture Prevention Effectiveness of Denosumab Versus Oral Bisphosphonates in Patients Receiving Dialysis : A Target Trial Emulation.
    Ann Intern Med. 2025 Jan 7. doi: 10.7326/ANNALS-24-03237.
    PubMed     Abstract available


  43. MORENO R
    In asymptomatic severe AS, early surgery vs. conservative therapy reduced a composite of death, MI, stroke, or HF hospitalization at 63 mo.
    Ann Intern Med. 2025 Jan 7. doi: 10.7326/ANNALS-24-03367.
    PubMed     Abstract available


  44. RICH MW
    In adults aged >/=75 y with NSTEMI, an invasive vs. conservative strategy did not improve a composite outcome at a median 4.1 y.
    Ann Intern Med. 2025;178:JC5.
    PubMed     Abstract available


    December 2024

  45. Correction: Deep Learning to Estimate Cardiovascular Risk From Chest Radiographs.
    Ann Intern Med. 2024 Dec 17. doi: 10.7326/ANNALS-24-03386.
    PubMed    


  46. NADERIAN M, Norland K, Schaid DJ, Kullo IJ, et al
    Development and Evaluation of a Comprehensive Prediction Model for Incident Coronary Heart Disease Using Genetic, Social, and Lifestyle-Psychological Factors: A Prospective Analysis of the UK Biobank.
    Ann Intern Med. 2024 Dec 10. doi: 10.7326/ANNALS-24-00716.
    PubMed     Abstract available


  47. CENTOR RM, Carson JL, Brooks MM
    Web Exclusive. Annals On Call - Transfusion Thresholds in Myocardial Infarction.
    Ann Intern Med. 2024;177:e2403587OC.
    PubMed    


  48. WEITZ HH, Merli GJ
    Web Exclusive. Annals Consult Guys - Cholesterol Management in Older Patients After Myocardial Infarction.
    Ann Intern Med. 2024;177:e2403798CG.
    PubMed    


  49. LADER E
    In stable CAD and aortic stenosis, adding routine PCI to TAVI reduced MACE but increased bleeding at 2 y.
    Ann Intern Med. 2024;177:JC139.
    PubMed     Abstract available


  50. KESARWANI M
    After PCI for ACS or stable CAD, DAPT for 1 mo vs. >1 mo reduces major bleeding without increasing stent thrombosis.
    Ann Intern Med. 2024;177:JC138.
    PubMed     Abstract available


    November 2024
  51. GIBSON LE, Wiener-Kronish JP, Fleisher LA
    From Risk to Recovery: Looking Ahead to the Next 50 Years of Preoperative Cardiovascular Assessment.
    Ann Intern Med. 2024 Nov 12. doi: 10.7326/ANNALS-24-02405.
    PubMed    


    October 2024
  52. WOODRUFF RC, Kaholokula JK, Riley L, Tong X, et al
    Cardiovascular Disease Mortality Among Native Hawaiian and Pacific Islander Adults Aged 35 Years or Older, 2018 to 2022.
    Ann Intern Med. 2024 Oct 15. doi: 10.7326/M24-0801.
    PubMed     Abstract available


  53. FITCH KV, Zanni MV, Manne-Goehler J, Diggs MR, et al
    Diabetes Risk Factors in People With HIV Receiving Pitavastatin Versus Placebo for Cardiovascular Disease Prevention : A Randomized Trial.
    Ann Intern Med. 2024 Oct 8. doi: 10.7326/ANNALS-24-00944.
    PubMed     Abstract available


  54. PORTELA GT, Carson JL, Swanson SA, Alexander JH, et al
    Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.
    Ann Intern Med. 2024 Oct 1. doi: 10.7326/M24-0571.
    PubMed     Abstract available


  55. BLOCH EM, Tobian AAR
    Relaxing Transfusion Thresholds for Patients With Myocardial Infarction: Findings From the MINT Trial.
    Ann Intern Med. 2024 Oct 1. doi: 10.7326/M24-0895.
    PubMed    


  56. SHARMA M, Srivastva A
    In ischemic stroke treated within 4.5 h, reteplase vs. alteplase increased excellent functional outcome at 90 d.
    Ann Intern Med. 2024 Oct 1. doi: 10.7326/ANNALS-24-02228.
    PubMed     Abstract available


    September 2024
  57. SEE C, Mooghali M, Dhruva SS, Ross JS, et al
    Class I Recalls of Cardiovascular Devices Between 2013 and 2022 : A Cross-Sectional Analysis.
    Ann Intern Med. 2024 Sep 17. doi: 10.7326/ANNALS-24-00724.
    PubMed     Abstract available


  58. MINHAS AMK, Virani SS, Michos ED, Nambi V, et al
    Comparing Cardiovascular Risk Classification of U.S. Adults According to Pooled Cohort Equations and PREVENT Equations: Cross-Sectional Analysis of the National Health and Nutrition Examination Survey.
    Ann Intern Med. 2024 Sep 3. doi: 10.7326/ANNALS-24-00074.
    PubMed    


  59. FATH AR, Elgendy IY
    After ACS, telemedicine-based care with remote patient monitoring vs. usual care reduced hospital readmissions at 6 mo.
    Ann Intern Med. 2024;177:JC105.
    PubMed     Abstract available


  60. MUKHERJEE D
    In patients with NSTE-ACS and previous CABG, routine invasive vs. conservative management does not improve outcomes.
    Ann Intern Med. 2024;177:JC104.
    PubMed     Abstract available


    August 2024
  61. CHAITOFF A, Bendicksen L, Feldman WB, Zheutlin AR, et al
    Estimating New Eligibility and Maximum Costs of Expanded Medicare Coverage of Semaglutide for Cardiovascular Risk Prevention.
    Ann Intern Med. 2024 Aug 27. doi: 10.7326/ANNALS-24-00308.
    PubMed    


  62. ANDERSON TS, Yeh RW, Herzig SJ, Marcantonio ER, et al
    Trends and Disparities in Ambulatory Follow-Up After Cardiovascular Hospitalizations : A Retrospective Cohort Study.
    Ann Intern Med. 2024 Aug 6. doi: 10.7326/M23-3475.
    PubMed     Abstract available


  63. CLIFFORD C, Yan AT
    After PCI and 1 mo of DAPT for ACS, ticagrelor alone vs. continued DAPT for 11 mo reduced bleeding without increasing MACCE.
    Ann Intern Med. 2024;177:JC86.
    PubMed     Abstract available


  64. SULEIMAN B, Granger CB
    In MI with preserved LVEF, long-term beta-blocker use vs. no use did not reduce all-cause death or MI at 3.5 y.
    Ann Intern Med. 2024;177:JC88.
    PubMed     Abstract available


    July 2024
  65. KEPPEL S, Borzak S
    In adults with AMI who are at risk for HF, empagliflozin did not reduce a composite of first HF hospitalization or all-cause death at 18 mo.
    Ann Intern Med. 2024;177:JC74.
    PubMed     Abstract available


    June 2024
  66. GUPTA M, Gulati S, Nasir K, Sarraju A, et al
    Aspirin Use Prevalence for Cardiovascular Disease Prevention Among U.S. Adults From 2012 to 2021.
    Ann Intern Med. 2024 Jun 25. doi: 10.7326/M24-0427.
    PubMed    


  67. GUALLAR E, Bravo PE, Ferrari VA
    Feeling the Heat: Cardiovascular Consequences of Heat Exposure Under Controlled Experimental Conditions.
    Ann Intern Med. 2024 Jun 11. doi: 10.7326/M24-0882.
    PubMed    


  68. BARRY H, Iglesies-Grau J, Chaseling GK, Paul J, et al
    The Effect of Heat Exposure on Myocardial Blood Flow and Cardiovascular Function.
    Ann Intern Med. 2024 Jun 11. doi: 10.7326/M24-3504.
    PubMed     Abstract available



  69. Correction: Diagnostic Strategies for the Assessment of Suspected Stable Coronary Artery Disease: A Systematic Review and Meta-analysis.
    Ann Intern Med. 2024 Jun 4. doi: 10.7326/ANNALS-24-00550.
    PubMed    


  70. CHIA JE, Mukherjee D
    After stent implantation for ACS, ticagrelor monotherapy after <1 mo of DAPT vs. 12 mo of DAPT improved 1-y net clinical benefit.
    Ann Intern Med. 2024;177:JC64.
    PubMed     Abstract available


    May 2024

  71. Annals Video Summary - Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men.
    Ann Intern Med. 2024 May 14:eM240479. doi: 10.7326/M24-0479.
    PubMed    


  72. YEAP BB, Marriott RJ, Dwivedi G, Adams RJ, et al
    Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men : Individual Participant Data Meta-analyses.
    Ann Intern Med. 2024 May 14. doi: 10.7326/M23-2781.
    PubMed     Abstract available


  73. BATES ER
    In patients with type 2 diabetes and recent MI, colchicine reduced a composite CV outcome at 23 mo.
    Ann Intern Med. 2024 May 7. doi: 10.7326/J24-0026.
    PubMed     Abstract available


  74. WEITZ HH, Merli GJ, Carson JL
    Web Exclusive. Annals Consult Guys - Acute Coronary Syndrome and Anemia: When to Transfuse?
    Ann Intern Med. 2024;177:eW240002.
    PubMed    


    April 2024
  75. YEN FS, Hwu CM, Liu JS, Wu YL, et al
    Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease.
    Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-1874.
    PubMed     Abstract available


  76. GREENWOOD H, Barnes K, Clark J, Ball L, et al
    Long-Term Effect of Salt Substitution for Cardiovascular Outcomes : A Systematic Review and Meta-Analysis.
    Ann Intern Med. 2024 Apr 9. doi: 10.7326/M23-2626.
    PubMed     Abstract available



  77. Annals Video Summary - Long-Term Effect of Salt Substitution for Cardiovascular Outcomes: A Systematic Review and Meta-analysis.
    Ann Intern Med. 2024 Apr 9:eM240208. doi: 10.7326/M24-0208.
    PubMed    


  78. KIRSCHNER J, Hunter B
    In suspected ACS, hs-cTnI- vs. c-cTnI-guided care was associated with improved outcomes at 5 y in certain subgroups.
    Ann Intern Med. 2024;177:JC41.
    PubMed     Abstract available


    March 2024
  79. WEISS J, Raghu VK, Paruchuri K, Zinzuwadia A, et al
    Deep Learning to Estimate Cardiovascular Risk From Chest Radiographs : A Risk Prediction Study.
    Ann Intern Med. 2024 Mar 26. doi: 10.7326/M23-1898.
    PubMed     Abstract available


  80. MUKHERJEE D
    In acute MI and anemia, restrictive vs. liberal transfusion did not differ for a composite of recurrent MI or death at 30 d.
    Ann Intern Med. 2024 Mar 5. doi: 10.7326/J24-0010.
    PubMed     Abstract available


  81. BAVISHI C
    In adults with stable angina, PCI vs. a placebo procedure reduced angina symptoms at 12 wk.
    Ann Intern Med. 2024;177:JC28.
    PubMed     Abstract available


  82. YONIS H, Granger CB
    In adults aged >/=80 y with NSTE-ACS, an invasive vs. conservative strategy improved outcomes at a median 5.3 y.
    Ann Intern Med. 2024;177:JC27.
    PubMed     Abstract available


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