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COVID-19: Daily Top 10 Papers

  Ischemic Heart Disease

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1 Am Heart J
7 Am J Cardiol
1 Am J Emerg Med
2 Am J Med
1 Ann Thorac Surg
2 Arterioscler Thromb Vasc Biol
15 Atherosclerosis
10 Circ Cardiovasc Interv
2 Circ Cardiovasc Qual Outcomes
4 Circ Genom Precis Med
1 Circ Res
9 Circulation
1 Crit Care Med
3 Curr Opin Cardiol
1 Heart
2 Int J Cardiol
5 J Am Coll Cardiol
2 J Cardiovasc Pharmacol
2 J Thromb Haemost
1 Lancet
4 PLoS One
1 Prog Cardiovasc Dis
1 Thromb Haemost

  Retrieve available abstracts of this week’s articles:
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Single Articles

    Am Heart J

  1. REDDY NK, Kaushal V, Kanaya AM, Kandula NR, et al
    Cardiovascular risk factor profiles in North and South Indian and Pakistani Americans: The MASALA Study.
    Am Heart J. 2021 Oct 21. pii: S0002-8703(21)00367.
    PubMed         Abstract available

    Am J Cardiol

  2. SHARMA A, Januzzi JL Jr, Suchindran S, Coles A, et al
    Utility of High-Sensitivity Troponin Among Stable Patients With Chest Pain Undergoing Stress Imaging (from PROMISE).
    Am J Cardiol. 2021;158:148-149.

  3. KOUNIS NG, Koniari I, Mplani V, Kouni SN, et al
    Acute Myocardial Infarction Within 24 Hours After COVID-19 Vaccination: Is Kounis Syndrome the Culprit?
    Am J Cardiol. 2021 Oct 23. pii: S0002-9149(21)00956.

  4. BOEDDINGHAUS J, Lopez-Ayala P, Nestelberger T, Koechlin L, et al
    Prospective Validation of the ESC 0/1h-Algorithm Using High-Sensitivity Cardiac Troponin I.
    Am J Cardiol. 2021;158:152-153.

  5. BAX AM, Yoon YE, Gianni U, Ma X, et al
    Plaque Character and Progression According to the Location of Coronary Atherosclerotic Plaque.
    Am J Cardiol. 2021;158:15-22.
    PubMed         Abstract available

  6. YAMAMOTO K, Natsuaki M, Morimoto T, Shiomi H, et al
    Ischemic and Bleeding Events After First Major Bleeding Event in Patients Undergoing Coronary Stent Implantation.
    Am J Cardiol. 2021 Oct 24. pii: S0002-9149(21)00938.
    PubMed         Abstract available

  7. OSMAN M, Syed M, Kheiri B, Divanji P, et al
    Survival After Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation.
    Am J Cardiol. 2021 Oct 23. pii: S0002-9149(21)00951.

  8. PATOULIAS D, Papadopoulos C, Imprialos K, Stavropoulos K, et al
    Meta-Analysis Assessing the Impact of Major Co-Morbidities, Gender, and Race on Cardiovascular Efficacy of Sodium-Glucose Co-Transporter-2 Inhibitors Among Patients With Heart Failure With Preserved or Reduced Ejection Fraction.
    Am J Cardiol. 2021 Oct 20. pii: S0002-9149(21)00949.

    Am J Emerg Med

  9. LIU TY, Tsai MT, Chen FC, Pan HY, et al
    Impact of coronary risk scores on disposition decision in emergency patients with chest pain.
    Am J Emerg Med. 2021;48:165-169.
    PubMed         Abstract available

    Am J Med

  10. BRUSH JE JR, Hajduk AM, Greene EJ, Dreyer RP, et al
    Sex Differences in Symptom Phenotypes Among Older Patients with Acute Myocardial Infarction.
    Am J Med. 2021 Oct 26. pii: S0002-9343(21)00705.
    PubMed         Abstract available

  11. DALEN JE, Goldberg RJ, Waterbrook A, Wylie L, et al
    Should Senior Citizens Take Aspirin Daily to Prevent Heart Attacks or Strokes?
    Am J Med. 2021;134:1185-1188.

    Ann Thorac Surg

  12. HUANG K, Wang Y, Huang J, Chu X, et al
    Nomogram Predicts Improvement of Ischemic Mitral Regurgitation after Coronary Artery Bypass Grafting.
    Ann Thorac Surg. 2021 Oct 22. pii: S0003-4975(21)01752.
    PubMed         Abstract available

    Arterioscler Thromb Vasc Biol

  13. RUFF CT, Koren MJ, Grimsby J, Rosenbaum AI, et al
    LEGACY: Phase 2a Trial to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamic Effects of the Anti-EL (Endothelial Lipase) Antibody MEDI5884 in Patients With Stable Coronary Artery Disease.
    Arterioscler Thromb Vasc Biol. 2021 Oct 28:ATVBAHA120315757.
    PubMed         Abstract available

  14. IGLESIAS MJ, Kruse LD, Sanchez-Rivera L, Enge L, et al
    Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors.
    Arterioscler Thromb Vasc Biol. 2021 Oct 28:ATVBAHA121316779.
    PubMed         Abstract available


  15. PEPE M, Napoli G, Carulli E, Moscarelli M, et al
    Autoimmune diseases in patients undergoing percutaneous coronary intervention: A risk factor for in-stent restenosis?
    Atherosclerosis. 2021;333:24-31.
    PubMed         Abstract available

  16. MARTINEZ-CEBALLOS MA, Sinning Rey JC, Alzate-Granados JP, Mendoza-Pinto C, et al
    Coronary calcium in autoimmune diseases: A systematic literature review and meta-analysis.
    Atherosclerosis. 2021;335:68-76.
    PubMed         Abstract available

  17. MAHENDIRAN T, Klingenberg R, Nanchen D, Gencer B, et al
    CCN family member 1 (CCN1) is an early marker of infarct size and left ventricular dysfunction in STEMI patients.
    Atherosclerosis. 2021;335:77-83.
    PubMed         Abstract available

  18. KIM H, Park JT, Lee J, Jung JY, et al
    The difference between cystatin C- and creatinine-based eGFR is associated with adverse cardiovascular outcome in patients with chronic kidney disease.
    Atherosclerosis. 2021;335:53-61.
    PubMed         Abstract available

    Correspondence to: "Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors".
    Atherosclerosis. 2021;335:148.

  20. NEGRINI S, von Eckardstein A
    Reply to: "Correspondence to: "Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors"".
    Atherosclerosis. 2021;335:149.

  21. VENKATARAMAN P, Huynh Q, Nicholls SJ, Stanton T, et al
    Impact of a coronary artery calcium-guided statin treatment protocol on cardiovascular risk at 12 months: Results from a pragmatic, randomised controlled trial.
    Atherosclerosis. 2021;334:57-65.
    PubMed         Abstract available

  22. BAMBAGIONI G, Di Mario C, Torguson R, Demola P, et al
    Lipid-rich plaques detected by near-infrared spectroscopy predict coronary events irrespective of age: A Lipid Rich Plaque sub-study.
    Atherosclerosis. 2021;334:17-22.
    PubMed         Abstract available

  23. AHMED AI, Han Y, Al Rifai M, Alnabelsi T, et al
    Added prognostic value of plaque burden to computed tomography angiography and myocardial perfusion imaging.
    Atherosclerosis. 2021;334:9-16.
    PubMed         Abstract available

  24. LIU Y, Liu S, Zhao Z, Song X, et al
    Phenylacetylglutamine is associated with the degree of coronary atherosclerotic severity assessed by coronary computed tomographic angiography in patients with suspected coronary artery disease.
    Atherosclerosis. 2021;333:75-82.
    PubMed         Abstract available

  25. AGBAEDENG TA, Noubiap JJ, Mofo Mato EP, Chew DP, et al
    Polygenic risk score and coronary artery disease: A meta-analysis of 979,286 participant data.
    Atherosclerosis. 2021;333:48-55.
    PubMed         Abstract available

  26. ALI HJ, Al-Mallah MH
    Time for sex specific atherosclerosis risk prediction.
    Atherosclerosis. 2021;333:87-88.

  27. VERNON ST, Kott KA, Hansen T, Zhang KJ, et al
    Coronary artery disease burden in women poorly explained by traditional risk factors: Sex disaggregated analyses from the BioHEART-CT study.
    Atherosclerosis. 2021;333:100-107.
    PubMed         Abstract available

  28. USUI E, Matsumura M, Mintz GS, Zhou Z, et al
    Clinical outcomes of low-intensity area without attenuation and cholesterol crystals in non-culprit lesions assessed by optical coherence tomography.
    Atherosclerosis. 2021;332:41-47.
    PubMed         Abstract available

  29. HAQUE W, Grandhi GR, Kanaya AM, Kandula NR, et al
    Implications of the 2019 American College of Cardiology/American Heart Association Primary Prevention Guidelines and potential value of the coronary artery calcium score among South Asians in the US: The Mediators of Atherosclerosis in South Asians Li
    Atherosclerosis. 2021;334:48-56.
    PubMed         Abstract available

    Circ Cardiovasc Interv

  30. PERDONCIN E, Bruce CG, Babaliaros VC, Yildirim DK, et al
    Balloon-Augmented Leaflet Modification With Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction and Laceration of the Anterior Mitral Leaflet to Prevent Outflow Obstruction: Benchtop Validati
    Circ Cardiovasc Interv. 2021 Oct 22:CIRCINTERVENTIONS121011028.
    PubMed         Abstract available

  31. JOVIN IS, McFalls EO
    Measurement of Cardiac Biomarkers Following Percutaneous Coronary Interventions for Chronic Total Occlusions: Still a Work in Progress.
    Circ Cardiovasc Interv. 2021 Oct 22:CIRCINTERVENTIONS121011390.

    Imaging and Physiology Get Along in the Left Main Coronary Artey Disease: The Case for Intravascular Ultrasound and Instantaneous Wave-Free Ratio.
    Circ Cardiovasc Interv. 2021 Jun 7:CIRCINTERVENTIONS121010887.

  33. SONG L, Wang Y, Guan C, Zou T, et al
    Impact of Periprocedural Myocardial Injury and Infarction Definitions on Long-Term Mortality After Chronic Total Occlusion Percutaneous Coronary Intervention.
    Circ Cardiovasc Interv. 2021 Oct 22:CIRCINTERVENTIONS121010923.
    PubMed         Abstract available

  34. COUGHLAN JJ, Aytekin A, Ndrepepa G, Schupke S, et al
    Ticagrelor or Prasugrel in Patients With Acute Coronary Syndrome Undergoing Complex Percutaneous Coronary Intervention.
    Circ Cardiovasc Interv. 2021;14:e010565.
    PubMed         Abstract available

  35. ESPOSITO G, Barbato E, Bartunek J
    Burden of In-Stent Restenosis: Shall We Overcome?
    Circ Cardiovasc Interv. 2021;14:e011292.

  36. LEE YJ, Zhang JJ, Mintz GS, Hong SJ, et al
    Impact of Intravascular Ultrasound-Guided Optimal Stent Expansion on 3-Year Hard Clinical Outcomes.
    Circ Cardiovasc Interv. 2021;14:e011124.
    PubMed         Abstract available

  37. ZHANG M, Matsumura M, Usui E, Noguchi M, et al
    Intravascular Ultrasound-Derived Calcium Score to Predict Stent Expansion in Severely Calcified Lesions.
    Circ Cardiovasc Interv. 2021;14:e010296.
    PubMed         Abstract available

  38. ERBAY A, Penzel L, Abdelwahed YS, Klotsche J, et al
    Prognostic Impact of Pancoronary Quantitative Flow Ratio Assessment in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes.
    Circ Cardiovasc Interv. 2021 Oct 22:CIRCINTERVENTIONS121010698.
    PubMed         Abstract available

  39. KANG SJ
    Intravascular Ultrasound-Derived Criteria for Optimal Stent Expansion and Preprocedural Prediction of Stent Underexpansion.
    Circ Cardiovasc Interv. 2021;14:e011374.

    Circ Cardiovasc Qual Outcomes

  40. DAWSON LP, Biswas S, Lefkovits J, Stub D, et al
    Characteristics and Quality of National Cardiac Registries: A Systematic Review.
    Circ Cardiovasc Qual Outcomes. 2021;14:e007963.
    PubMed         Abstract available

  41. OSERAN AS, Wadhera RK
    Promise and Pitfalls of Paying-for-Performance: Learning From the Polish Experience.
    Circ Cardiovasc Qual Outcomes. 2021;14:e008273.

    Circ Genom Precis Med

  42. MANIKPURAGE HD, Eslami A, Perrot N, Li Z, et al
    Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men.
    Circ Genom Precis Med. 2021 Oct 21:CIRCGEN121003452.
    PubMed         Abstract available

  43. OLSON NC, Raffield LM, Moxley AH, Miller-Fleming TW, et al
    Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Blacks.
    Circ Genom Precis Med. 2021 Oct 28:CIRCGEN121003421.
    PubMed         Abstract available

  44. AMRANI-MIDOUN A, Adlam D, Bouatia-Naji N
    Recent Advances on the Genetics of Spontaneous Coronary Artery Dissection.
    Circ Genom Precis Med. 2021 Oct 28:CIRCGEN121003393.
    PubMed         Abstract available

  45. PARCHA V, Heindl BF, Li P, Kalra R, et al
    Genotype-Guided P2Y12 Inhibitor Therapy After Percutaneous Coronary Intervention: A Bayesian Analysis.
    Circ Genom Precis Med. 2021 Oct 21:CIRCGEN121003353.
    PubMed         Abstract available

    Circ Res

  46. LUI KO, Huang Y
    Chaperone Mediated Autophagy Regulates eNOS Uncoupling in Cardiovascular Events.
    Circ Res. 2021;129:946-948.


  47. PENG AW, Dardari ZA, Blaha MJ
    Response by Peng et al to Letter Regarding Article, "Very High Coronary Artery Calcium (>/=1000) and Association With Cardiovascular Disease Events, Non-Cardiovascular Disease Outcomes, and Mortality: Results From MESA".
    Circulation. 2021;144:e275-e276.

  48. ALE-AGHA N, Jakobs P, Goy C, Zurek M, et al
    Mitochondrial Telomerase Reverse Transcriptase Protects from Myocardial Ischemia/reperfusion Injury by Improving Complex I Composition and Function.
    Circulation. 2021 Oct 21. doi: 10.1161/CIRCULATIONAHA.120.051923.
    PubMed         Abstract available

  49. YAZAKI Y, Nakamura M, Iijima R, Yasuda S, et al
    Clinical Outcomes of Rivaroxaban Monotherapy in Heart Failure Patients With Atrial Fibrillation and Stable Coronary Disease: Insights From the AFIRE Trial.
    Circulation. 2021;144:1449-1451.

  50. VERMA S, Bhatt DL, Steg PG, Miller M, et al
    Icosapent Ethyl Reduces Ischemic Events in Patients with a History of Prior Coronary Artery Bypass Grafting: REDUCE-IT CABG.
    Circulation. 2021 Oct 28. doi: 10.1161/CIRCULATIONAHA.121.056290.
    PubMed         Abstract available

  51. MAJITHIA A, Bhatt DL, Friedman AN, Miller M, et al
    Benefits of Icosapent Ethyl Across the Range of Kidney Function in Patients with Established Cardiovascular Disease or Diabetes: REDUCE-IT RENAL.
    Circulation. 2021 Oct 28. doi: 10.1161/CIRCULATIONAHA.121.055560.
    PubMed         Abstract available

    Letter by Braillon Regarding Article, "Very High Coronary Artery Calcium (>/=1000) and Association With Cardiovascular Disease Events, Non-Cardiovascular Disease Outcomes, and Mortality: Results From MESA".
    Circulation. 2021;144:e274.

  53. SANCHEZ-LOPEZ A, Espinos-Estevez C, Gonzalez-Gomez C, Gonzalo P, et al
    Cardiovascular Progerin Suppression and lamin A Restoration Rescues Hutchinson-Gilford Progeria Syndrome.
    Circulation. 2021 Oct 25. doi: 10.1161/CIRCULATIONAHA.121.055313.
    PubMed         Abstract available

  54. NEELAND IJ, McGuire DK, Sattar N
    Cardiovascular Outcomes Trials for Weight Loss Interventions: Another Tool for Cardiovascular Prevention?
    Circulation. 2021;144:1359-1361.

  55. KRIS-ETHERTON PM, Petersen KS, Despres JP, Anderson CAM, et al
    Strategies for Promotion of a Healthy Lifestyle in Clinical Settings: Pillars of Ideal Cardiovascular Health: A Science Advisory From the American Heart Association.
    Circulation. 2021 Oct 25:CIR0000000000001018. doi: 10.1161/CIR.0000000000001018.
    PubMed         Abstract available

    Crit Care Med

  56. BORGEL D, Chocron R, Grimaud M, Philippe A, et al
    Endothelial Dysfunction as a Component of Severe Acute Respiratory Syndrome Coronavirus 2-Related Multisystem Inflammatory Syndrome in Children With Shock.
    Crit Care Med. 2021;49:e1151-e1156.
    PubMed         Abstract available

    Curr Opin Cardiol

  57. DZAYE O, Razavi AC, Blaha MJ, Mortensen MB, et al
    Evaluation of coronary stenosis versus plaque burden for atherosclerotic cardiovascular disease risk assessment and management.
    Curr Opin Cardiol. 2021;36:769-775.
    PubMed         Abstract available

  58. ANDREINI D, Conte E, Serruys PW
    Coronary plaque features on CTA can identify patients at increased risk of cardiovascular events.
    Curr Opin Cardiol. 2021;36:784-792.
    PubMed         Abstract available

  59. METEVA D, Seppelt C, Abdelwahed YS, Leistner DM, et al
    Distinct pathological mechanisms distinguish acute coronary syndrome caused by plaque erosion from plaque rupture.
    Curr Opin Cardiol. 2021;36:793-797.
    PubMed         Abstract available


  60. DE LUCA G, Algowhary M, Uguz B, Oliveira DC, et al
    COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction.
    Heart. 2021 Oct 28. pii: heartjnl-2021-319750. doi: 10.1136/heartjnl-2021-319750
    PubMed         Abstract available

    Int J Cardiol

  61. BOUISSET F, Deney A, Ferrieres J, Panagides V, et al
    Mechanical complications in ST-elevation myocardial infarction: The impact of pre-hospital delay.
    Int J Cardiol. 2021 Oct 23. pii: S0167-5273(21)01574.
    PubMed         Abstract available

  62. HAN X, Chen Z, Wang Y, Zhang J, et al
    Prognostic significance of QRS distortion and frontal QRS-T angle in patients with ST-elevation myocardial infarction.
    Int J Cardiol. 2021 Oct 26. pii: S0167-5273(21)01693.
    PubMed         Abstract available

    J Am Coll Cardiol

  63. GRUBERG L, Gandotra P
    STEMI Following TAVR: Unusual But Definitely Not Trivial.
    J Am Coll Cardiol. 2021;77:2200-2203.

  64. BARAC A, Sharon E
    From Detecting Signals to Understanding Cardiovascular Toxicities of Cancer Therapies: All the Light We Could See.
    J Am Coll Cardiol. 2021;78:1814-1816.

  65. GOLDMAN A, Maor E, Bomze D, Liu JE, et al
    Adverse Cardiovascular and Pulmonary Events Associated With Chimeric Antigen Receptor T-Cell Therapy.
    J Am Coll Cardiol. 2021;78:1800-1813.
    PubMed         Abstract available

  66. WANNER PM, Wulff DU, Djurdjevic M, Korte W, et al
    Targeting Higher Intraoperative Blood Pressures Does Not Reduce Adverse Cardiovascular Events Following Noncardiac Surgery.
    J Am Coll Cardiol. 2021;78:1753-1764.
    PubMed         Abstract available

  67. ITOGA NK, Tawfik DS, Montez-Rath ME, Chang TI, et al
    Contributions of Systolic and Diastolic Blood Pressures to Cardiovascular Outcomes in the ALLHAT Study.
    J Am Coll Cardiol. 2021;78:1671-1678.
    PubMed         Abstract available

    J Cardiovasc Pharmacol

  68. ZHANG Y, Zhao X, Ye Y, Li Q, et al
    Clinical Outcomes after Percutaneous Coronary Intervention Over Time on the Basis of CYP2C19 Polymorphisms.
    J Cardiovasc Pharmacol. 2021 Oct 26. pii: 00005344-900000000-98125.
    PubMed         Abstract available

  69. MELITA H, Manolis AA, Manolis TA, Manolis AS, et al
    Lipoprotein (a) and Cardiovascular Disease: A Missing Link for Premature Atherosclerotic Heart Disease and/or Residual Risk.
    J Cardiovasc Pharmacol. 2021 Oct 20. pii: 00005344-900000000-98128.
    PubMed         Abstract available

    J Thromb Haemost

  70. FOLSOM AR, de Vries PS, Cushman M
    No prospective association of a polygenic risk score for coronary artery disease with venous thromboembolism incidence.
    J Thromb Haemost. 2021;19:2841-2844.
    PubMed         Abstract available

  71. CHEN H, Shen M, Niu R, Mu X, et al
    Associations of coagulation factor X and XI with incident acute coronary syndrome and stroke: A nested case-control study.
    J Thromb Haemost. 2021;19:2781-2790.
    PubMed         Abstract available


  72. FANAROFF AC, Garcia S, Giri J
    Myocardial Infarction During the COVID-19 Pandemic.
    JAMA. 2021 Oct 29. pii: 2785894. doi: 10.1001/jama.2021.19608.

  73. SAAD M, Kennedy KF, Imran H, Louis DW, et al
    Association Between COVID-19 Diagnosis and In-Hospital Mortality in Patients Hospitalized With ST-Segment Elevation Myocardial Infarction.
    JAMA. 2021 Oct 29. pii: 2785893. doi: 10.1001/jama.2021.18890.
    PubMed         Abstract available


  74. DEL PRATO S, Kahn SE, Pavo I, Weerakkody GJ, et al
    Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial.
    Lancet. 2021 Oct 18. pii: S0140-6736(21)02188.
    PubMed         Abstract available

    PLoS One

  75. ZHU X, Umezu M, Iwasaki K
    Finite element analysis of cutting balloon expansion in a calcified artery model of circular angle 180 degrees : Effects of balloon-to-diameter ratio and number of blades facing calcification on potential calcification fracturing and perforation reduc
    PLoS One. 2021;16:e0251404.
    PubMed         Abstract available

  76. GURM Z, Seth M, Daher E, Pielsticker E, et al
    Prevalence of coronary risk factors in contemporary practice among patients undergoing their first percutaneous coronary intervention: Implications for primary prevention.
    PLoS One. 2021;16:e0250801.
    PubMed         Abstract available

  77. CORBALLIS NH, Paddock S, Gunawardena T, Merinopoulos I, et al
    Drug coated balloons for coronary artery bifurcation lesions: A systematic review and focused meta-analysis.
    PLoS One. 2021;16:e0251986.
    PubMed         Abstract available

  78. HO MY, Chen PW, Feng WH, Su CH, et al
    Effect of aspirin treatment duration on clinical outcomes in acute coronary syndrome patients with early aspirin discontinuation and received P2Y12 inhibitor monotherapy.
    PLoS One. 2021;16:e0251109.
    PubMed         Abstract available

    Prog Cardiovasc Dis

  79. SMITH JR, Taylor BJ
    Inspiratory muscle weakness in cardiovascular diseases: Implications for cardiac rehabilitation.
    Prog Cardiovasc Dis. 2021 Oct 21. pii: S0033-0620(21)00116.
    PubMed         Abstract available

    Thromb Haemost

  80. MCCUTCHEON K, Manga P
    Human Immunodeficiency Virus and Cardiovascular Disease: Revisiting the Inflammation-Thrombosis Axis.
    Thromb Haemost. 2021 Oct 24. doi: 10.1055/s-0041-1736445.

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