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Chronic Heart Failure

Free Subscription Articles published in Circ Res Retrieve available abstracts of 85 articles: HTML format

Single Articles

May 2026
1. HEGYI B, Angsutararux P, Chakouri N, Mahling RW, et al
   Targeting Arrhythmogenic Late Sodium Current by FHF1(A)-Derivative FixR in Heart Failure Cardiomyocytes.
   Circ Res. 2026 May 26:10.1161/CIRCRESAHA.126.328204.
   PubMed     Abstract available
   
   
   
2. MERAL D, Mamazhakypov A, Koca D, Mukherjee D, et al
   Reversible Fibroblast Trajectories Regulated by MR Underlie Diastolic Dysfunction.
   Circ Res. 2026;138:e327301.
   PubMed     Abstract available
   
   
   
3. HAHN VS, Chaffin M, Simonson B, Jenkin SC, et al
   Single Cell Analysis of Human Heart Failure With Preserved Ejection Fraction.
   Circ Res. 2026 May 15. doi: 10.1161/CIRCRESAHA.125.327433.
   PubMed     Abstract available
   
   
   
4. NGUYEN VB, Kapiloff MS
   AH001: A New Drug Targeting RhoA in Heart Failure.
   Circ Res. 2026;138:e328631.
   PubMed    
   
   
   April 2026
5. SCHANBACHER C, Lorenz K
   Phosphoinositides in Chronic Ang II Signaling: PTEN-A Target in Heart Failure?
   Circ Res. 2026;138:e328513.
   PubMed    
   
   
   
6. WESTHOFF M, Voelker TL, Del Villar SG, Thai PN, et al
   Phosphoinositide Depletion and Compensatory Phospho-Signaling in Angiotensin II-Induced Heart Disease.
   Circ Res. 2026;138:e327896.
   PubMed     Abstract available
   
   
   
7. WANG X, Han S, Zhang G, Huang X, et al
   ESCRT-Mediated Machinery Directly Drives Cardiac T-tubule Formation.
   Circ Res. 2026;138:e327453.
   PubMed     Abstract available
   
   
   March 2026
8. RATNAVADIVEL S, Zhang J, Sheikh F
   Signal Override: Precision Editing of Protein Kinase Calpha in Heart Failure.
   Circ Res. 2026;138:e328024.
   PubMed    
   
   
   
9. XUE M, Liang Y, Yuan Z, Liu X, et al
   Inhibiting RhoA Activation Via GDP-State Stabilization to Relieve Heart Failure.
   Circ Res. 2026 Mar 20. doi: 10.1161/CIRCRESAHA.125.327107.
   PubMed     Abstract available
   
   
   
10. HORNER KB, Mutchler AL
    Indole Loss: Hypertensive Link Between Dysbiosis and Diastolic Heart Failure.
    Circ Res. 2026;138:e328284.
    PubMed    
    
    
    
11. ZAKARAUSKAS-SETH BI, Forcari G, Anandakumar H, Kotlar-Goldaper I, et al
    Indole-3 Acetate Limits Dysbiosis-Driven Diastolic Failure via Hcrt Neurons.
    Circ Res. 2026;138:e326990.
    PubMed     Abstract available
    
    
    February 2026
12. TADOKORO T, Li H, Gan P, Xu Z, et al
    Ablation of PKCalpha Phosphorylation by CRISPR-Cas9 Base Editing Rescues Heart Failure.
    Circ Res. 2026 Feb 20. doi: 10.1161/CIRCRESAHA.125.326738.
    PubMed     Abstract available
    
    
    January 2026
13. CARLEY AN, Maurya SK, Maurya CK, Wang Y, et al
    CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer.
    Circ Res. 2026;138:e327403.
    PubMed     Abstract available
    
    
    
14. HAYES JB, Choudhary D, Ritter D, Neininger-Castro AC, et al
    Nonmuscle alpha-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling.
    Circ Res. 2026;138:e326412.
    PubMed     Abstract available
    
    
    December 2025
15. CHEN M, Wang Z, Li J, Teng P, et al
    Histone Lactylation Promotes Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Regulating TGFB2 Expression.
    Circ Res. 2025 Dec 11. doi: 10.1161/CIRCRESAHA.125.326185.
    PubMed     Abstract available
    
    
    October 2025
16. PARTHIBAN P, Barrow F, Wang H, Chalise U, et al
    Macrophage-Derived CCL24 Promotes Cardiac Fibrosis Via Fibroblast CCR3.
    Circ Res. 2025;137:1140-1156.
    PubMed     Abstract available
    
    
    September 2025
17. ELBATREEK MH, Lefer DJ
    Unlocking Mitochondrial Potential: DWORF to the Rescue in Heart Failure.
    Circ Res. 2025;137:1089-1091.
    PubMed    
    
    
    
18. YUCEL D, Ferreira de Araujo N, Souza-Neto F, Smith C, et al
    Septin4 Regulates Cardiac Fibrosis After Pressure Overload.
    Circ Res. 2025;137:1117-1132.
    PubMed     Abstract available
    
    
    
19. BRITO-ESTRADA O, Kuwabara Y, Gibson AM, Hassel KR, et al
    DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function.
    Circ Res. 2025;137:1072-1088.
    PubMed     Abstract available
    
    
    
20. LI Z, LaPenna KB, Gehred ND, Yu X, et al
    Dysregulated Protein s-Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction.
    Circ Res. 2025 Sep 17. doi: 10.1161/CIRCRESAHA.124.326042.
    PubMed     Abstract available
    
    
    
21. WU H, Zhuang Y, Yue Y, Liu J, et al
    SPOP Is a Key Trigger of Pathological Cardiac Hypertrophy and Heart Failure.
    Circ Res. 2025 Sep 15. doi: 10.1161/CIRCRESAHA.125.326129.
    PubMed     Abstract available
    
    
    August 2025
22. PALACIOS-MERINO J, Lara-Pezzi E
    Cutting Loose to Hold on: A Feedback Loop Between GPLD1 and uPAR in Heart Failure.
    Circ Res. 2025;137:584-586.
    PubMed    
    
    
    
23. KNEUER JM, Muller M, Erbe S, Kokot KE, et al
    Circulating Immune Cell Signature Analysis in HFpEF Across Species.
    Circ Res. 2025;137:682-698.
    PubMed     Abstract available
    
    
    
24. VENKATESAN T, Toumpourleka M, Niewiadomska M, Farhat K, et al
    Vagal Stimulation Rescues HFpEF by Altering Cardiac Resident Macrophage Function.
    Circ Res. 2025;137:664-681.
    PubMed     Abstract available
    
    
    
25. PERALTA TM, Zelarayan LC
    Dot1L-H3K79me2-Tbx6 Axis: A Novel Therapeutic Target for Preventing Cardiac Failure.
    Circ Res. 2025;137:513-515.
    PubMed    
    
    
    July 2025
26. YU W, Guo Z, Liang H, Ma D, et al
    GPLD1 Attenuates Heart Failure via Dual Membrane Localization to Inhibit uPAR.
    Circ Res. 2025 Jul 9. doi: 10.1161/CIRCRESAHA.124.325623.
    PubMed     Abstract available
    
    
    
27. SUBRAMANIAN V, Tucker WJ, Peters AE, Upadhya B, et al
    Cardiovascular Aging and Exercise: Implications for Heart Failure Prevention and Management.
    Circ Res. 2025;137:205-230.
    PubMed     Abstract available
    
    
    
28. LEWIS GD, Tada A, Landsteiner I, Borlaug BA, et al
    Physiologic Phenotyping of Responses to Exercise and Activity in Heart Failure.
    Circ Res. 2025;137:290-315.
    PubMed     Abstract available
    
    
    
29. MOUNSEY LA, Guo M, Lau ES, Ho JE, et al
    Exercise Training in Heart Failure: Clinical Benefits and Mechanisms.
    Circ Res. 2025;137:273-289.
    PubMed     Abstract available
    
    
    June 2025
30. PEPIN ME, Konrad PJM, Nazir S, Bazgir F, et al
    Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF.
    Circ Res. 2025;136:1564-1578.
    PubMed     Abstract available
    
    
    May 2025
31. CALLER T, Moore KJ, Lehmann LH, Wu SM, et al
    Insights Into Heart-Tumor Interactions in Heart Failure.
    Circ Res. 2025;136:1262-1285.
    PubMed     Abstract available
    
    
    
32. JUGUILON C, Khosravi R, Radisic M, Wu JC, et al
    In Vitro Modeling of Interorgan Crosstalk: Multi-Organ-on-a-Chip for Studying Cardiovascular-Kidney-Metabolic Syndrome.
    Circ Res. 2025;136:1476-1493.
    PubMed     Abstract available
    
    
    
33. SALYER LG, Wang Y, Ma X, Foryst-Ludwig A, et al
    Modulating the Secretome of Fat to Treat Heart Failure.
    Circ Res. 2025;136:1363-1381.
    PubMed     Abstract available
    
    
    
34. SNELSON M, R Muralitharan R, Liu CF, Marko L, et al
    Gut-Heart Axis: The Role of Gut Microbiota and Metabolites in Heart Failure.
    Circ Res. 2025;136:1382-1406.
    PubMed     Abstract available
    
    
    
35. LEE CJM, Kosyakovsky LB, Khan MS, Wu F, et al
    Cardiovascular, Kidney, Liver, and Metabolic Interactions in Heart Failure: Breaking Down Silos.
    Circ Res. 2025;136:1170-1207.
    PubMed     Abstract available
    
    
    
36. KALLIKOURDIS M, Cochran JD, Walsh K, Condorelli G, et al
    Contributions of Noncardiac Organ-Heart Immune Crosstalk and Somatic Mosaicism to Heart Failure: Current Knowledge and Perspectives.
    Circ Res. 2025;136:1208-1232.
    PubMed     Abstract available
    
    
    
37. SCHIATTARELLA GG, Kontaridis MI
    Interorgan Crosstalk in Heart Failure and Cardiometabolic Diseases: A Compendium.
    Circ Res. 2025;136:1167-1169.
    PubMed    
    
    
    
38. NOELS H, van der Vorst EPC, Rubin S, Emmett A, et al
    Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure.
    Circ Res. 2025;136:1306-1334.
    PubMed     Abstract available
    
    
    
39. KOAY YC, McIntosh B, Ng YH, Cao Y, et al
    The Heart Has Intrinsic Ketogenic Capacity that Mediates NAD(+) Therapy in HFpEF.
    Circ Res. 2025;136:1113-1130.
    PubMed     Abstract available
    
    
    
40. COSTANTINO S, Mohammed SA, Ambrosini S, Telesca M, et al
    Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF.
    Circ Res. 2025;136:1079-1095.
    PubMed     Abstract available
    
    
    March 2025
41. GHAZAL R, Wang M, Liu D, Tschumperlin DJ, et al
    Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure.
    Circ Res. 2025;136:773-802.
    PubMed     Abstract available
    
    
    
42. HAN X, Shi Q, Tu Y, Zhang J, et al
    Cardiomyocyte PRL2 Promotes Cardiac Hypertrophy via Directly Dephosphorylating AMPKalpha2.
    Circ Res. 2025;136:645-663.
    PubMed     Abstract available
    
    
    December 2024
43. MARTINI E, Cremonesi M, Felicetta A, Serio S, et al
    Autoimmune-Like Mechanism in Heart Failure Enables Preventive Vaccine Therapy.
    Circ Res. 2024 Dec 4. doi: 10.1161/CIRCRESAHA.124.324999.
    PubMed     Abstract available
    
    
    October 2024
44. YOSHII A, McMillen TS, Wang Y, Zhou B, et al
    Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF.
    Circ Res. 2024;135:1004-1017.
    PubMed     Abstract available
    
    
    September 2024
45. STROCCHI S, Liu L, Wang R, Haseli SP, et al
    Systems Biology Approach Uncovers Candidates for Liver-Heart Interorgan Crosstalk in HFpEF.
    Circ Res. 2024;135:873-876.
    PubMed    
    
    
    
46. DELAUNAY M, Jebessa ZH, McKinsey TA
    Cyclophilin(g) a Knowledge Gap in Heart Failure Pathogenesis.
    Circ Res. 2024;135:774-776.
    PubMed    
    
    
    
47. MUNRO ML, Gonano LA
    On the Mend: Atrial Tubulogenesis After Tachypacing-Induced Heart Failure.
    Circ Res. 2024;135:755-757.
    PubMed    
    
    
    
48. SIGLE M, Rohlfing AK, Cruz Santos M, Kopp T, et al
    Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts.
    Circ Res. 2024;135:758-773.
    PubMed     Abstract available
    
    
    August 2024
49. SANTIAGO PADILLA L, Schiattarella GG
    Targeting HFpEF: Unlocking the Potential of Glucagon Receptor Blockade.
    Circ Res. 2024;135:629-631.
    PubMed    
    
    
    
50. BERGER JH, Matsuura TR, Bowman CE, Taing R, et al
    SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice.
    Circ Res. 2024;135:632-634.
    PubMed    
    
    
    
51. CALDWELL JL, Clarke JD, Smith CER, Pinali C, et al
    Restoring Atrial T-Tubules Augments Systolic Ca Upon Recovery From Heart Failure.
    Circ Res. 2024 Aug 14. doi: 10.1161/CIRCRESAHA.124.324601.
    PubMed     Abstract available
    
    
    
52. PAVELEC CM, Young AP, Luviano HL, Orrell EE, et al
    Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy.
    Circ Res. 2024;135:503-517.
    PubMed     Abstract available
    
    
    July 2024
53. GAO C, Xiong Z, Liu Y, Wang M, et al
    Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction.
    Circ Res. 2024 Jul 16. doi: 10.1161/CIRCRESAHA.124.324706.
    PubMed     Abstract available
    
    
    
54. LEE CJM, Foo RS
    TRIM35: A Proposed Gateway to p53-Induced Heart Failure Pathogenesis.
    Circ Res. 2024;135:314-316.
    PubMed    
    
    
    
55. HINTON A JR, Claypool SM, Neikirk K, Senoo N, et al
    Mitochondrial Structure and Function in Human Heart Failure.
    Circ Res. 2024;135:372-396.
    PubMed     Abstract available
    
    
    June 2024
56. ROMAN B, Mastoor Y, Sun J, Chapoy Villanueva H, et al
    MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy.
    Circ Res. 2024;135:26-40.
    PubMed     Abstract available
    
    
    
57. LORENZANA-CARRILLO MA, Tejay S, Nanoa J, Huang G, et al
    TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure.
    Circ Res. 2024 Jun 11. doi: 10.1161/CIRCRESAHA.123.324202.
    PubMed     Abstract available
    
    
    
58. MALLAREDY V, Roy R, Cheng Z, Gurrala CT, et al
    Tipifarnib Reduces Extracellular Vesicles and Protects From Heart Failure.
    Circ Res. 2024 Jun 7. doi: 10.1161/CIRCRESAHA.123.324110.
    PubMed     Abstract available
    
    
    
59. ALCAIDE P, Kallikourdis M, Emig R, Prabhu SD, et al
    Myocardial Inflammation in Heart Failure With Reduced and Preserved Ejection Fraction.
    Circ Res. 2024;134:1752-1766.
    PubMed     Abstract available
    
    
    May 2024
60. LIEM DA, Olivera da Silva H, Romero E, Rocha P, et al
    Association of Neighborhood and Environmental Factors with Clinical Phenotypes and Outcomes in Heart Failure with Preserved Ejection Fraction.
    Circ Res. 2024 May 17. doi: 10.1161/CIRCRESAHA.124.324429.
    PubMed    
    
    
    April 2024
61. QASIM H, Rajaei M, Xu Y, Reyes-Alcaraz A, et al
    AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.
    Circ Res. 2024;134:1006-1022.
    PubMed     Abstract available
    
    
    March 2024
62. ECKLE T, Bertazzo J, Khatua TN, Fatemi Tabatabaei SR, et al
    Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure.
    Circ Res. 2024;134:675-694.
    PubMed     Abstract available
    
    
    
63. CURAJ A, Vanholder R, Loscalzo J, Quach K, et al
    Cardiovascular Consequences of Uremic Metabolites: an Overview of the Involved Signaling Pathways.
    Circ Res. 2024;134:592-613.
    PubMed     Abstract available
    
    
    February 2024
64. KAMRADT ML, Makarewich CA
    CHKB-DT: A Long Noncoding RNA Critical for Cardiovascular Health.
    Circ Res. 2024;134:442-444.
    PubMed    
    
    
    
65. VACCA A, Schiattarella GG
    From Gut to Heart: Role of Indole-3-Propionic Acid in HFpEF.
    Circ Res. 2024;134:390-392.
    PubMed    
    
    
    January 2024
66. WANG YC, Koay YC, Pan C, Zhou Z, et al
    Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction.
    Circ Res. 2024 Jan 24. doi: 10.1161/CIRCRESAHA.123.322381.
    PubMed     Abstract available
    
    
    December 2023
67. STEGE NM, Eijgenraam TR, Oliveira Nunes Teixeira V, Feringa AM, et al
    DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters.
    Circ Res. 2023;133:1006-1021.
    PubMed     Abstract available
    
    
    November 2023
68. DAI Z, Thorp EB
    New Way to Study Pulmonary Hypertension in HFpEF.
    Circ Res. 2023;133:899-901.
    PubMed    
    
    
    
69. AGRAWAL V, Kropski JA, Gokey JJ, Kobeck E, et al
    Myeloid Cell Derived IL1beta Contributes to Pulmonary Hypertension in HFpEF.
    Circ Res. 2023;133:885-898.
    PubMed     Abstract available
    
    
    
70. KWAN Z, Paulose Nadappuram B, Leung MM, Mohagaonkar S, et al
    Microtubule-Mediated Regulation of beta(2)AR Translation and Function in Failing Hearts.
    Circ Res. 2023;133:944-958.
    PubMed     Abstract available
    
    
    October 2023
71. LIU D, Wang M, Murthy V, McNamara DM, et al
    Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis.
    Circ Res. 2023;133:810-825.
    PubMed     Abstract available
    
    
    September 2023
72. SERIO S, Pagiatakis C, Musolino E, Felicetta A, et al
    Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis.
    Circ Res. 2023;133:687-703.
    PubMed     Abstract available
    
    
    July 2023
73. 
    Correction to: SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes.
    Circ Res. 2023;133:e48.
    PubMed    
    
    
    
74. TANG X, Zhao S, Liu J, Liu X, et al
    Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation.
    Circ Res. 2023;133:220-236.
    PubMed     Abstract available
    
    
    
75. DAI Y, Ignatyeva N, Xu H, Wali R, et al
    An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes.
    Circ Res. 2023;133:e19-e46.
    PubMed     Abstract available
    
    
    June 2023
76. FATKIN D, Ohanian M, Brown KJ
    A Novel Role for FKBP5 in Atrial Cardiomyopathy.
    Circ Res. 2023;133:45-47.
    PubMed    
    
    
    
77. SANCHEZ-ALONSO JL, Fedele L, Copier JS, Lucarelli C, et al
    Functional LTCC-beta(2)AR Complex Needs Caveolin-3 and Is Disrupted in Heart Failure.
    Circ Res. 2023 Jun 14. doi: 10.1161/CIRCRESAHA.123.322508.
    PubMed     Abstract available
    
    
    May 2023
78. NAYAKANTI SR, Friedrich A, Sarode P, Jafari L, et al
    Targeting Wnt-ss-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling.
    Circ Res. 2023;132:1468-1485.
    PubMed     Abstract available
    
    
    
79. BOULOS PK, Freeman SV, Henry TD, Mahmud E, et al
    Interaction of COVID-19 With Common Cardiovascular Disorders.
    Circ Res. 2023;132:1259-1271.
    PubMed     Abstract available
    
    
    April 2023
80. NGUYEN TD, Schulze PC
    Cardiac Metabolism in Heart Failure and Implications for Uremic Cardiomyopathy.
    Circ Res. 2023;132:1034-1049.
    PubMed     Abstract available
    
    
    
81. WU Z, Lohmoller J, Kuhl C, Wehrle K, et al
    Use of Computation Ecosystems to Analyze the Kidney-Heart Crosstalk.
    Circ Res. 2023;132:1084-1100.
    PubMed     Abstract available
    
    
    March 2023
82. MATSUURA TR, Puchalska P, Crawford PA, Kelly DP, et al
    Ketones and the Heart: Metabolic Principles and Therapeutic Implications.
    Circ Res. 2023;132:882-898.
    PubMed     Abstract available
    
    
    
83. YE S, Huang H, Han X, Luo W, et al
    Dectin-1 Acts as a Non-Classical Receptor of Ang II to Induce Cardiac Remodeling.
    Circ Res. 2023;132:707-722.
    PubMed     Abstract available
    
    
    
84. CANNAVO A, Jun S, Rengo G, Marzano F, et al
    beta3AR-Dependent BDNF (Brain-Derived Neurotrophic Factor) Generation Limits Chronic Postischemic Heart Failure.
    Circ Res. 2023 Mar 8. doi: 10.1161/CIRCRESAHA.122.321583.
    PubMed     Abstract available
    
    
    
85. HUGHES A, Shandhi MMH, Master H, Dunn J, et al
    Wearable Devices in Cardiovascular Medicine.
    Circ Res. 2023;132:652-670.
    PubMed     Abstract available
    
    

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