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  Chronic Heart Failure

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Articles published in Circ Res

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    February 2021
  1. MUSTROPH J, Sag CM, Bahr F, Schmidtmann AL, et al
    Loss of CASK Accelerates Heart Failure Development.
    Circ Res. 2021 Feb 17. doi: 10.1161/CIRCRESAHA.120.318170.
    PubMed     Abstract available

    Heart Failure in Diabetes: Still a Vexing Problem.
    Circ Res. 2021;128:358-359.

  3. MANGNER N, Garbade J, Heyne E, van den Berg M, et al
    Molecular Mechanisms of Diaphragm Myopathy in Humans with Severe Heart Failure.
    Circ Res. 2021 Feb 1. doi: 10.1161/CIRCRESAHA.120.318060.
    PubMed     Abstract available

  4. LIU T, Yang N, Sidor A, O'Rourke B, et al
    MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca(2+) Leak.
    Circ Res. 2021 Feb 1. doi: 10.1161/CIRCRESAHA.120.318562.
    PubMed     Abstract available

    January 2021
  5. EVANS MA, Walsh K
    A Single-Cell Analysis of DNMT3A-Mediated Clonal Hematopoiesis in Heart Failure.
    Circ Res. 2021;128:229-231.

    December 2020
  6. WITTENBECHER C, Eichelmann F, Toledo E, Guasch-Ferre M, et al
    Lipid Profiles and Heart Failure Risk: Results from Two Prospective Studies.
    Circ Res. 2020 Dec 4. doi: 10.1161/CIRCRESAHA.120.317883.
    PubMed     Abstract available

    November 2020
  7. ABPLANALP WT, Cremer S, John D, Hoffmann J, et al
    Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.
    Circ Res. 2020 Nov 6. doi: 10.1161/CIRCRESAHA.120.317104.
    PubMed     Abstract available

    September 2020
  8. SCOTT I, Sack MN
    Rethinking Protein Acetylation in Pressure Overload-Induced Heart Failure.
    Circ Res. 2020;127:1109-1111.

    August 2020
  9. MARTINI E, Cremonesi M, Panico C, Carullo P, et al
    T Cell Costimulation Blockade Blunts Age-Related Heart Failure.
    Circ Res. 2020 Aug 17. doi: 10.1161/CIRCRESAHA.119.316530.

    July 2020
  10. DAVIDSON MT, Grimsrud P, Lai L, Draper J, et al
    Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.
    Circ Res. 2020 Jul 14. doi: 10.1161/CIRCRESAHA.120.317293.
    PubMed     Abstract available

    May 2020
  11. MARTINS-MARQUES T, Catarino S, Goncalves A, Miranda-Silva D, et al
    EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases.
    Circ Res. 2020;126:e97-e113.
    PubMed     Abstract available

    March 2020
  12. JOLY JM, Tallaj JA
    The Heart of the (Gray) Matter Is not Black and White.
    Circ Res. 2020;126:765-766.

  13. WANG S, Li Y, Xu Y, Ma Q, et al
    AAV Gene Therapy Prevents and Reverses Heart Failure in A Murine Knockout Model of Barth Syndrome.
    Circ Res. 2020 Mar 9. doi: 10.1161/CIRCRESAHA.119.315956.
    PubMed     Abstract available

    February 2020
  14. LI H, Hastings MH, Rhee J, Trager LE, et al
    Targeting Age-Related Pathways in Heart Failure.
    Circ Res. 2020;126:533-551.
    PubMed     Abstract available

    January 2020
  15. EISNER DA, Caldwell JL, Trafford AW, Hutchings DC, et al
    The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications.
    Circ Res. 2020;126:395-412.
    PubMed     Abstract available

  16. MUELLER K, Thiel F, Beutner F, Teren A, et al
    Brain Damage with Heart Failure: Cardiac Biomarker Alterations and Gray Matter Decline.
    Circ Res. 2020 Jan 23. doi: 10.1161/CIRCRESAHA.119.315813.
    PubMed     Abstract available

    December 2019
  17. TUAL-CHALOT S, Garcia-Collado M, Redgrave RE, Singh E, et al
    Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signalling.
    Circ Res. 2019 Dec 6. doi: 10.1161/CIRCRESAHA.119.315974.
    PubMed     Abstract available

    August 2019

  18. Correction to: Phase 3 DREAM-HF Trial of Mesenchymal Precursor Cells in Chronic Heart Failure: A Review of Biological Plausibility and Implementation of Flexible Clinical Trial Design.
    Circ Res. 2019;125:e28.

  19. PFEFFER MA, Shah AM, Borlaug BA
    Response by Pfeffer et al to Letter Regarding Article, "Heart Failure With Preserved Ejection Fraction in Perspective".
    Circ Res. 2019;125:e26.

  20. NIKOLOVA AP, Hong T, Shaw RM
    Letter by Nikolova et al Regarding Article, "Heart Failure With Preserved Ejection Fraction in Perspective".
    Circ Res. 2019;125:e24-e25.

    July 2019
  21. BOROW KM, Yaroshinsky A, Greenberg B, Perin EC, et al
    Phase 3 DREAM-HF Trial of Mesenchymal Precursor Cells in Chronic Heart Failure.
    Circ Res. 2019;125:265-281.
    PubMed     Abstract available

    June 2019
    The Extracellular Matrix in Ischemic and Nonischemic Heart Failure.
    Circ Res. 2019;125:117-146.
    PubMed     Abstract available

  23. Correction to: Role of SIRT1 in Modulating Acetylation of the Sarco- Endoplasmic Reticulum Ca(2+)-ATPase in Heart Failure.
    Circ Res. 2019;124:e149.

    May 2019
  24. ELGENDY IY, Mahtta D, Pepine CJ
    Medical Therapy for Heart Failure Caused by Ischemic Heart Disease.
    Circ Res. 2019;124:1520-1535.
    PubMed     Abstract available

  25. PFEFFER MA, Shah AM, Borlaug BA
    Heart Failure With Preserved Ejection Fraction In Perspective.
    Circ Res. 2019;124:1598-1617.
    PubMed     Abstract available

  26. ZELT JGE, Chaudhary KR, Cadete VJ, Mielniczuk LM, et al
    Medical Therapy for Heart Failure Associated With Pulmonary Hypertension.
    Circ Res. 2019;124:1551-1567.
    PubMed     Abstract available

  27. HEALLEN TR, Kadow ZA, Kim JH, Wang J, et al
    Stimulating Cardiogenesis as a Treatment for Heart Failure.
    Circ Res. 2019;124:1647-1657.
    PubMed     Abstract available

  28. PINILLA-VERA M, Hahn VS, Kass DA
    Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction.
    Circ Res. 2019;124:1618-1632.
    PubMed     Abstract available

  29. MILLER L, Birks E, Guglin M, Lamba H, et al
    Use of Ventricular Assist Devices and Heart Transplantation for Advanced Heart Failure.
    Circ Res. 2019;124:1658-1678.
    PubMed     Abstract available

    The Medical and Device-Related Treatment of Heart Failure.
    Circ Res. 2019;124:1519.

  31. HUSSEIN AA, Wilkoff BL
    Cardiac Implantable Electronic Device Therapy in Heart Failure.
    Circ Res. 2019;124:1584-1597.
    PubMed     Abstract available

  32. TSCHOPE C, Cooper LT, Torre-Amione G, Van Linthout S, et al
    Management of Myocarditis-Related Cardiomyopathy in Adults.
    Circ Res. 2019;124:1568-1583.
    PubMed     Abstract available

    April 2019
  33. CHEN X, Zhang X, Gross S, Houser SR, et al
    Acetylation of SERCA2a, Another Target for Heart Failure Treatment?
    Circ Res. 2019;124:1285-1287.

    Diabetic Cardiomyopathy.
    Circ Res. 2019;124:1160-1162.

  35. STIERMAIER T, Jensen JO, Rommel KP, de Waha-Thiele S, et al
    Combined Intrahospital Remote Ischemic Perconditioning and Postconditioning Improves Clinical Outcome in ST-Elevation Myocardial Infarction: Long-Term Results of the LIPSIA CONDITIONING Trial.
    Circ Res. 2019 Apr 1. doi: 10.1161/CIRCRESAHA.118.314500.
    PubMed     Abstract available

    March 2019
  36. ESCHENHAGEN T, Weinberger F
    Heart Repair With Myocytes.
    Circ Res. 2019;124:843-845.

  37. BINDER P, Wang S, Radu M, Zin M, et al
    Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response.
    Circ Res. 2019;124:696-711.
    PubMed     Abstract available

  38. QUAN C, Li M, Du Q, Chen Q, et al
    SPEG Controls Calcium Reuptake Into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain.
    Circ Res. 2019;124:712-726.
    PubMed     Abstract available

    February 2019
  39. GORSKI PA, Jang SP, Jeong D, Lee A, et al
    Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca(2+)-ATPase in Heart Failure.
    Circ Res. 2019 Feb 21. doi: 10.1161/CIRCRESAHA.118.313865.
    PubMed     Abstract available

    Cholesterol-Lowering Agents.
    Circ Res. 2019;124:354-363.
    PubMed     Abstract available

    January 2019
  41. CIMATO TR, Canty JM Jr
    Right Ventricular Pulmonary Coupling as a Therapeutic Target in Heart Failure With Preserved Ejection Fraction.
    Circ Res. 2019;124:186-188.

    Paul Simpson.
    Circ Res. 2019;124:195-198.

  43. IKEDA S, Mizushima W, Sciarretta S, Abdellatif M, et al
    Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.
    Circ Res. 2019;124:292-305.
    PubMed     Abstract available

  44. NI L, Scott L Jr, Campbell HM, Pan X, et al
    Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector.
    Circ Res. 2019;124:256-262.
    PubMed     Abstract available

  45. KENNY HC, Abel ED
    Heart Failure in Type 2 Diabetes Mellitus.
    Circ Res. 2019;124:121-141.
    PubMed     Abstract available

  46. BERRY JL, Zhu W, Tang YL, Krishnamurthy P, et al
    Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.
    Circ Res. 2019;124:161-169.
    PubMed     Abstract available

  47. FREED JK
    Healing the Broken Heart With Adrenomedullin.
    Circ Res. 2019;124:15-17.

  48. GARRY DJ, Garry MG
    Interspecies Chimeras and the Generation of Humanized Organs.
    Circ Res. 2019;124:23-25.

    December 2018
  49. TRAC D, Maxwell JT, Brown ME, Xu C, et al
    Aggregation of Child Cardiac Progenitor Cells into Spheres Activates Notch Signaling and Improves Treatment of Right Ventricular Heart Failure.
    Circ Res. 2018 Dec 28. doi: 10.1161/CIRCRESAHA.118.313845.
    PubMed     Abstract available

    October 2018
  50. REDDY YN, Obokata M, Koepp KE, Egbe AC, et al
    beta-Adrenergic Agonist Albuterol Improves Pulmonary Vascular Reserve in Heart Failure with Preserved Ejection Fraction: A Randomized Controlled Trial.
    Circ Res. 2018 Oct 30. doi: 10.1161/CIRCRESAHA.118.313832.
    PubMed     Abstract available

  51. TRINCOT CE, Xu W, Zhang H, Kulikauskas MR, et al
    Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Cx43.
    Circ Res. 2018 Oct 11. doi: 10.1161/CIRCRESAHA.118.313835.
    PubMed     Abstract available

    August 2018
  52. IBRAHIM NE, Januzzi JL Jr
    Established and Emerging Roles of Biomarkers in Heart Failure.
    Circ Res. 2018;123:614-629.
    PubMed     Abstract available

    July 2018
  53. GYONGYOSI M, Haller PM, Blake DJ, Martin Rendon E, et al
    Meta-Analysis of Cell Therapy Studies in Heart Failure and Acute Myocardial Infarction.
    Circ Res. 2018;123:301-308.
    PubMed     Abstract available

    June 2018
  54. DEY S, DeMazumder D, Sidor A, Foster DB, et al
    Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure.
    Circ Res. 2018 Jun 13. pii: CIRCRESAHA.118.312708.
    PubMed     Abstract available

    May 2018
  55. BARTUNEK J, Terzic A, Behfar A, Wijns W, et al
    Clinical Experience With Regenerative Therapy in Heart Failure: Advancing Care With Cardiopoietic Stem Cell Interventions.
    Circ Res. 2018;122:1344-1346.

    April 2018
  56. BOLLI R, Hare JM, March KL, Pepine CJ, et al
    Rationale and Design of the CONCERT-HF (Combination Of meseNchymal and c-kit(+) Cardiac stEm cells as Regenerative Therapy for Heart Failure) Trial.
    Circ Res. 2018 Apr 27. pii: CIRCRESAHA.118.312978.
    PubMed     Abstract available

    March 2018
  57. YANG PC
    Induced Pluripotent Stem Cell (iPSC)-Derived Exosomes for Precision Medicine in Heart Failure.
    Circ Res. 2018;122:661-663.

    February 2018
  58. RAINER PP, Dong P, Sorge M, Fert-Bober J, et al
    Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure.
    Circ Res. 2018 Feb 26. pii: CIRCRESAHA.117.312082.
    PubMed     Abstract available

  59. PACKER M
    Do Dipeptidyl Peptidase-4 Inhibitors Cause Heart Failure Events by Promoting Adrenergically-Mediated Cardiotoxicity? Clues from Laboratory Models and Clinical Trials.
    Circ Res. 2018 Feb 7. pii: CIRCRESAHA.118.312673.
    PubMed     Abstract available

    January 2018
  60. SANO T, Ousaka D, Goto T, Ishigami S, et al
    Impact of Cardiac Progenitor Cells on Heart Failure and Survival in Single Ventricle Congenital Heart Disease.
    Circ Res. 2018 Jan 24. pii: CIRCRESAHA.117.312311.
    PubMed     Abstract available

  61. MIYAZAKI T, Otani K, Chiba A, Nishimura H, et al
    A New Secretory Peptide of Natriuretic Peptide Family, Osteocrin, Suppresses the Progression of Congestive Heart Failure After Myocardial Infarction.
    Circ Res. 2018 Jan 11. pii: CIRCRESAHA.117.312624.
    PubMed     Abstract available

  62. ARGULIAN E, Chandrashekhar Y, Shah SJ, Huttin O, et al
    Teasing Apart Heart Failure With Preserved Ejection Fraction Phenotypes With Echocardiographic Imaging: Potential Approach to Research and Clinical Practice.
    Circ Res. 2018;122:23-25.

    December 2017
  63. WANG B, Nie J, Wu L, Hu Y, et al
    AMPKalpha2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation.
    Circ Res. 2017 Dec 28. pii: CIRCRESAHA.117.312317.
    PubMed     Abstract available

  64. LANG D, Sato D, Jiang Y, Ginsburg KS, et al
    Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart.
    Circ Res. 2017;121:1379-1391.
    PubMed     Abstract available

  65. VAN DER HARST P, Verweij N
    The Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
    Circ Res. 2017 Dec 6. pii: CIRCRESAHA.117.312086.
    PubMed     Abstract available

    September 2017
  66. BARTOLUCCI JG, Verdugo FJ, Gonzalez PL, Larrea RE, et al
    Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure: A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial).
    Circ Res. 2017 Sep 26. pii: CIRCRESAHA.117.310712.
    PubMed     Abstract available

    August 2017
  67. PICCOLI MT, Gupta SK, Viereck J, Foinquinos A, et al
    Inhibition of the Cardiac Fibroblast-Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction.
    Circ Res. 2017;121:575-583.
    PubMed     Abstract available

  68. BISCHOFF FC, Werner A, John D, Boeckel JN, et al
    Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes.
    Circ Res. 2017;121:368-375.
    PubMed     Abstract available

    June 2017
  69. TRAVERSE JH, Henry TD
    Myocardial Injury as a New Target for Cell Therapy in Patients With Chronic Heart Failure: When Something Bad Is Actually Good?
    Circ Res. 2017;120:1857-1859.

  70. FU Y, Shaw RM
    CASAAV Technology to Examine Regulators of Heart Failure: Cause or Effect.
    Circ Res. 2017;120:1846-1848.

    March 2017
  71. SHARMA K, Kass DA
    Inorganic Nitrates: Qi for Heart Failure With Preserved Ejection Fraction?
    Circ Res. 2017;120:1057-1059.

  72. LUU B, Leistner DM, Herrmann E, Seeger FH, et al
    Minute Myocardial Injury as Measured by High-Sensitive Troponin T Serum Levels Predicts the Response to Intracoronary Infusion of Bone Marrow-Derived Mononuclear Cells in Patients with Stable Chronic Post-Infarction Heart Failure: Insights from the TO
    Circ Res. 2017 Mar 28. pii: CIRCRESAHA.116.309938.
    PubMed     Abstract available

  73. HINTON RB, Ware SM
    Heart Failure in Pediatric Patients With Congenital Heart Disease.
    Circ Res. 2017;120:978-994.
    PubMed     Abstract available

    February 2017
  74. FAZAL L, Laudette M, Paula-Gomes S, Pons S, et al
    Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.
    Circ Res. 2017;120:645-657.
    PubMed     Abstract available

    January 2017
  75. CHAN SH, Chan JY
    Phosphodiesterase 2 as a Therapeutic Target for Heart Failure: Is Upregulation an Option?
    Circ Res. 2017;120:13-16.

  76. APPARI M, Breitbart A, Brandes F, Szaroszyk M, et al
    C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure.
    Circ Res. 2017;120:66-77.
    PubMed     Abstract available

  77. QUICK AP, Wang Q, Philippen LE, Barreto-Torres G, et al
    SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.
    Circ Res. 2017;120:110-119.
    PubMed     Abstract available

    December 2016
  78. ZAMANI P, Tan VX, Soto-Calderon H, Beraun M, et al
    Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction.
    Circ Res. 2016 Dec 7. pii: CIRCRESAHA.116.309832.
    PubMed     Abstract available

    October 2016
  79. JAE N, Dimmeler S
    Titin Forms Circles: Regulation by Heart Failure and the RNA-Binding Protein RBM20.
    Circ Res. 2016;119:966-968.

    September 2016
  80. BULL M, Methawasin M, Strom J, Nair P, et al
    Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnDeltaIAjxn).
    Circ Res. 2016;119:764-72.
    PubMed     Abstract available

    May 2016
  81. SHAH MS, Brownlee M
    Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes.
    Circ Res. 2016;118:1808-29.
    PubMed     Abstract available

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