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  Neoplasms of the CNS

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Articles published in Acta Neuropathol

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    April 2021
  1. FORSTER A, Brand F, Banan R, Huneburg R, et al
    Rare germline variants in the E-cadherin gene CDH1 are associated with the risk of brain tumors of neuroepithelial and epithelial origin.
    Acta Neuropathol. 2021 Apr 30. pii: 10.1007/s00401-021-02307.
    PubMed     Abstract available


  2. SUWALA AK, Stichel D, Schrimpf D, Maas SLN, et al
    Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1.
    Acta Neuropathol. 2021 Apr 19. pii: 10.1007/s00401-021-02302.
    PubMed     Abstract available


  3. RICKERT D, Bartl J, Picard D, Bernardi F, et al
    Circular RNA profiling distinguishes medullobastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma.
    Acta Neuropathol. 2021 Apr 17. pii: 10.1007/s00401-021-02306.
    PubMed    


    February 2021
  4. FISHER MJ, Jones DTW, Li Y, Guo X, et al
    Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1).
    Acta Neuropathol. 2021 Feb 14. pii: 10.1007/s00401-021-02276.
    PubMed     Abstract available


  5. SCHULLER U, Iglauer P, Dorostkar MM, Mawrin C, et al
    Correction to: Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations.
    Acta Neuropathol. 2021 Feb 9. pii: 10.1007/s00401-021-02273.
    PubMed    


    January 2021
  6. SCHULLER U, Iglauer P, Dorostkar MM, Mawrin C, et al
    Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations.
    Acta Neuropathol. 2021 Jan 12. pii: 10.1007/s00401-020-02259.
    PubMed    


  7. FUKUMURA K, Malgulwar PB, Fischer GM, Hu X, et al
    Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis.
    Acta Neuropathol. 2021 Jan 4. pii: 10.1007/s00401-020-02256.
    PubMed     Abstract available


    December 2020
  8. SIEVERS P, Sill M, Blume C, Tauziede-Espariat A, et al
    Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1.
    Acta Neuropathol. 2020 Dec 14. pii: 10.1007/s00401-020-02247.
    PubMed     Abstract available


    October 2020
  9. KEENAN C, Graham RT, Harreld JH, Lucas JT Jr, et al
    Infratentorial C11orf95-fused gliomas share histologic, immunophenotypic, and molecular characteristics of supratentorial RELA-fused ependymoma.
    Acta Neuropathol. 2020 Oct 24. pii: 10.1007/s00401-020-02238.
    PubMed    


  10. PASSOS J, Quidet M, Brahimi A, Flament C, et al
    Familial adenomatous polyposis associated craniopharyngioma secondary to both germline and somatic mutations in the APC gene.
    Acta Neuropathol. 2020 Oct 6. pii: 10.1007/s00401-020-02232.
    PubMed    


  11. GOLEBIEWSKA A, Hau AC, Oudin A, Stieber D, et al
    Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.
    Acta Neuropathol. 2020 Oct 3. pii: 10.1007/s00401-020-02226.
    PubMed     Abstract available


    September 2020
  12. DODGSHUN AJ, Fukuoka K, Edwards M, Bianchi VJ, et al
    Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns.
    Acta Neuropathol. 2020 Sep 8. pii: 10.1007/s00401-020-02209.
    PubMed     Abstract available


    August 2020
  13. LIU APY, Priesterbach-Ackley LP, Orr BA, Li BK, et al
    WNT-activated embryonal tumors of the pineal region: ectopic medulloblastomas or a novel pineoblastoma subgroup?
    Acta Neuropathol. 2020 Aug 8. pii: 10.1007/s00401-020-02208.
    PubMed    


    July 2020
  14. SIEVERS P, Hielscher T, Schrimpf D, Stichel D, et al
    CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas.
    Acta Neuropathol. 2020 Jul 8. pii: 10.1007/s00401-020-02188.
    PubMed    


    June 2020
  15. PUN M, Haggerty-Skeans J, Pratt D, Fudym Y, et al
    H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in a young adult with COVID-19-associated coagulopathy.
    Acta Neuropathol. 2020 Jun 29. pii: 10.1007/s00401-020-02184.
    PubMed    


  16. SARATSIS AM, Kambhampati M, Snyder K, Yadavilli S, et al
    Correction to: Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes.
    Acta Neuropathol. 2020 Jun 19. pii: 10.1007/s00401-020-02162.
    PubMed     Abstract available


  17. SMITH KS, Xu K, Mercer KS, Boop F, et al
    Patient-derived orthotopic xenografts of pediatric brain tumors: a St. Jude resource.
    Acta Neuropathol. 2020 Jun 10. pii: 10.1007/s00401-020-02171.
    PubMed     Abstract available


    May 2020
  18. EBERHART CG, Bar EE
    Spatial enrichment of cellular states in glioblastoma.
    Acta Neuropathol. 2020 May 24. pii: 10.1007/s00401-020-02165.
    PubMed    


  19. WILLIAMS EA, Wakimoto H, Shankar GM, Barker FG 2nd, et al
    Frequent inactivating mutations of the PBAF complex gene PBRM1 in meningioma with papillary features.
    Acta Neuropathol. 2020 May 13. pii: 10.1007/s00401-020-02161.
    PubMed    


    April 2020
  20. MONDAL G, Lee JC, Ravindranathan A, Villanueva-Meyer JE, et al
    Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.
    Acta Neuropathol. 2020 Apr 17. pii: 10.1007/s00401-020-02155.
    PubMed     Abstract available


    March 2020
  21. CASTEL D, Kergrohen T, Tauziede-Espariat A, Mackay A, et al
    Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation.
    Acta Neuropathol. 2020 Mar 19. pii: 10.1007/s00401-020-02142.
    PubMed    


  22. ZEPEDA-MENDOZA CJ, Vaubel RA, Zarei S, Ida CM, et al
    Concomitant 1p/19q co-deletion and IDH1/2, ATRX, and TP53 mutations within a single clone of "dual-genotype" IDH-mutant infiltrating gliomas.
    Acta Neuropathol. 2020 Mar 13. pii: 10.1007/s00401-020-02141.
    PubMed    


  23. SLOAN EA, Hilz S, Gupta R, Cadwell C, et al
    Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features.
    Acta Neuropathol. 2020 Mar 10. pii: 10.1007/s00401-020-02144.
    PubMed    


    February 2020
  24. LIU APY, Gudenas B, Lin T, Orr BA, et al
    Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials.
    Acta Neuropathol. 2020;139:259-271.
    PubMed     Abstract available


  25. PFAFF E, Aichmuller C, Sill M, Stichel D, et al
    Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations.
    Acta Neuropathol. 2020;139:243-257.
    PubMed     Abstract available


  26. THOMAS C, Wefers A, Bens S, Nemes K, et al
    Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults.
    Acta Neuropathol. 2020;139:277-286.
    PubMed     Abstract available


  27. SIEVERS P, Schrimpf D, Stichel D, Reuss DE, et al
    Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation.
    Acta Neuropathol. 2020;139:403-406.
    PubMed    


  28. NEUMANN JE, Spohn M, Obrecht D, Mynarek M, et al
    Molecular characterization of histopathological ependymoma variants.
    Acta Neuropathol. 2020;139:305-318.
    PubMed     Abstract available


  29. GARETON A, Tauziede-Espariat A, Dangouloff-Ros V, Roux A, et al
    The histomolecular criteria established for adult anaplastic pilocytic astrocytoma are not applicable to the pediatric population.
    Acta Neuropathol. 2020;139:287-303.
    PubMed     Abstract available


    January 2020
  30. KIM B, Tabori U, Hawkins C
    An update on the CNS manifestations of brain tumor polyposis syndromes.
    Acta Neuropathol. 2020 Jan 22. pii: 10.1007/s00401-020-02124.
    PubMed     Abstract available


  31. FELLER C, Felix M, Weiss T, Herold-Mende C, et al
    Histone epiproteomic profiling distinguishes oligodendroglioma, IDH-mutant and 1p/19q co-deleted from IDH-mutant astrocytoma and reveals less tri-methylation of H3K27 in oligodendrogliomas.
    Acta Neuropathol. 2020;139:211-213.
    PubMed    


    December 2019
  32. CHIANG J, Li X, Liu APY, Qaddoumi I, et al
    Tectal glioma harbors high rates of KRAS G12R and concomitant KRAS and BRAF alterations.
    Acta Neuropathol. 2019 Dec 10. pii: 10.1007/s00401-019-02112.
    PubMed    


  33. LI BK, Vasiljevic A, Dufour C, Yao F, et al
    Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study.
    Acta Neuropathol. 2019 Dec 9. pii: 10.1007/s00401-019-02111.
    PubMed     Abstract available


    November 2019
  34. KORSHUNOV A, Okonechnikov K, Sahm F, Ryzhova M, et al
    Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker.
    Acta Neuropathol. 2019 Nov 28. pii: 10.1007/s00401-019-02102.
    PubMed     Abstract available


  35. SIEVERS P, Chiang J, Schrimpf D, Stichel D, et al
    YAP1-fusions in pediatric NF2-wildtype meningioma.
    Acta Neuropathol. 2019 Nov 16. pii: 10.1007/s00401-019-02095.
    PubMed    


    October 2019
  36. CHIANG J, Harreld JH, Tinkle CL, Moreira DC, et al
    A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration.
    Acta Neuropathol. 2019 Oct 8. pii: 10.1007/s00401-019-02081.
    PubMed    


    September 2019
  37. WEFERS AK, Stichel D, Schrimpf D, Coras R, et al
    Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.
    Acta Neuropathol. 2019 Sep 28. pii: 10.1007/s00401-019-02078.
    PubMed     Abstract available


  38. SLOAN EA, Cooney T, Oberheim Bush NA, Buerki R, et al
    Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas.
    Acta Neuropathol. 2019 Sep 12. pii: 10.1007/s00401-019-02072.
    PubMed    


    August 2019
  39. BRAND F, Forster A, Christians A, Bucher M, et al
    FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas.
    Acta Neuropathol. 2019 Aug 31. pii: 10.1007/s00401-019-02067.
    PubMed     Abstract available


  40. DAY BW, Lathia JD, Bruce ZC, D'Souza RCJ, et al
    The dystroglycan receptor maintains glioma stem cells in the vascular niche.
    Acta Neuropathol. 2019 Aug 28. pii: 10.1007/s00401-019-02069.
    PubMed     Abstract available


  41. JANIN M, Ortiz-Barahona V, de Moura MC, Martinez-Cardus A, et al
    Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program.
    Acta Neuropathol. 2019 Aug 19. pii: 10.1007/s00401-019-02062.
    PubMed     Abstract available


    May 2019
  42. SHARMA T, Schwalbe EC, Williamson D, Sill M, et al
    Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes.
    Acta Neuropathol. 2019 May 10. pii: 10.1007/s00401-019-02020.
    PubMed     Abstract available


  43. PARAMASIVAM N, Hubschmann D, Toprak UH, Ishaque N, et al
    Mutational patterns and regulatory networks in epigenetic subgroups of meningioma.
    Acta Neuropathol. 2019 May 8. pii: 10.1007/s00401-019-02008.
    PubMed     Abstract available


  44. FILIPSKI K, Braun Y, Zinke J, Roller B, et al
    Lack of H3K27 trimethylation is associated with 1p/19q codeletion in diffuse gliomas.
    Acta Neuropathol. 2019 May 7. pii: 10.1007/s00401-019-02025.
    PubMed    


  45. WIRTHSCHAFT P, Bode J, Soni H, Dietrich F, et al
    RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas.
    Acta Neuropathol. 2019 May 6. pii: 10.1007/s00401-019-02021.
    PubMed     Abstract available


    April 2019
  46. KORSHUNOV A, Okonechnikov K, Sahm F, Ryzhova M, et al
    Molecular progression of SHH-activated medulloblastomas.
    Acta Neuropathol. 2019 Apr 27. pii: 10.1007/s00401-019-02022.
    PubMed    


  47. SILVEIRA AB, Kasper LH, Fan Y, Jin H, et al
    Correction to: H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo.
    Acta Neuropathol. 2019 Apr 11. pii: 10.1007/s00401-019-02006.
    PubMed     Abstract available


    March 2019
  48. ELLISON DW, Hawkins C, Jones DTW, Onar-Thomas A, et al
    cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAF(V600E) mutation.
    Acta Neuropathol. 2019 Mar 8. pii: 10.1007/s00401-019-01987.
    PubMed    


  49. BLANLUET M, Masliah-Planchon J, Giurgea I, Bielle F, et al
    SHH medulloblastoma in a young adult with a TCF4 germline pathogenic variation.
    Acta Neuropathol. 2019 Mar 8. pii: 10.1007/s00401-019-01983.
    PubMed    


  50. HELLWIG M, Lauffer MC, Bockmayr M, Spohn M, et al
    TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma.
    Acta Neuropathol. 2019 Mar 4. pii: 10.1007/s00401-019-01982.
    PubMed     Abstract available


  51. KORSHUNOV A, Sahm F, Okonechnikov K, Ryzhova M, et al
    Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles.
    Acta Neuropathol. 2019 Mar 2. pii: 10.1007/s00401-019-01981.
    PubMed     Abstract available


    February 2019
  52. SILVEIRA AB, Kasper LH, Fan Y, Jin H, et al
    H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo.
    Acta Neuropathol. 2019 Feb 15. pii: 10.1007/s00401-019-01975.
    PubMed     Abstract available


  53. FRITCHIE K, Jensch K, Moskalev EA, Caron A, et al
    The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma.
    Acta Neuropathol. 2019;137:307-319.
    PubMed     Abstract available


    October 2018
  54. SIEVERS P, Stichel D, Hielscher T, Schrimpf D, et al
    Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p.
    Acta Neuropathol. 2018 Oct 31. pii: 10.1007/s00401-018-1924.
    PubMed    


    September 2018
  55. XU K, Ding L, Chang TC, Shao Y, et al
    Structure and evolution of double minutes in diagnosis and relapse brain tumors.
    Acta Neuropathol. 2018 Sep 28. pii: 10.1007/s00401-018-1912.
    PubMed     Abstract available


  56. BRAT DJ, Aldape K, Colman H, Holland EC, et al
    cIMPACT-NOW update 3: recommended diagnostic criteria for "Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV".
    Acta Neuropathol. 2018 Sep 26. pii: 10.1007/s00401-018-1913.
    PubMed    


  57. LOPEZ GY, Van Ziffle J, Onodera C, Grenert JP, et al
    The genetic landscape of gliomas arising after therapeutic radiation.
    Acta Neuropathol. 2018 Sep 8. pii: 10.1007/s00401-018-1906.
    PubMed     Abstract available


  58. STICHEL D, Ebrahimi A, Reuss D, Schrimpf D, et al
    Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.
    Acta Neuropathol. 2018 Sep 5. pii: 10.1007/s00401-018-1905.
    PubMed     Abstract available


    August 2018
  59. VALERA ET, McConechy MK, Gayden T, Rivera B, et al
    Methylome analysis and whole-exome sequencing reveal that brain tumors associated with encephalocraniocutaneous lipomatosis are midline pilocytic astrocytomas.
    Acta Neuropathol. 2018 Aug 24. pii: 10.1007/s00401-018-1898.
    PubMed    


  60. JURATLI TA, McCabe D, Nayyar N, Williams EA, et al
    DMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome.
    Acta Neuropathol. 2018 Aug 19. pii: 10.1007/s00401-018-1899.
    PubMed     Abstract available


  61. VON BUEREN AO, Karremann M, Gielen GH, Benesch M, et al
    Correction to: A suggestion to introduce the diagnosis of "diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)".
    Acta Neuropathol. 2018 Aug 16. pii: 10.1007/s00401-018-1896.
    PubMed     Abstract available


    June 2018
  62. YANG RR, Aibaidula A, Wang WW, Chan AK, et al
    Pediatric low-grade gliomas can be molecularly stratified for risk.
    Acta Neuropathol. 2018 Jun 14. pii: 10.1007/s00401-018-1874.
    PubMed     Abstract available


    May 2018
  63. VON BUEREN AO, Karremann M, Gielen GH, Benesch M, et al
    A suggestion to introduce the diagnosis of "diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)".
    Acta Neuropathol. 2018 May 21. pii: 10.1007/s00401-018-1863.
    PubMed    


  64. LESKE H, Rushing E, Budka H, Niehusmann P, et al
    K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution.
    Acta Neuropathol. 2018 May 15. pii: 10.1007/s00401-018-1867.
    PubMed    


    April 2018
  65. SHIRAHATA M, Ono T, Stichel D, Schrimpf D, et al
    Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.
    Acta Neuropathol. 2018 Apr 23. pii: 10.1007/s00401-018-1849.
    PubMed     Abstract available


  66. PHI JH, Park AK, Lee S, Choi SA, et al
    Genomic analysis reveals secondary glioblastoma after radiotherapy in a subset of recurrent medulloblastomas.
    Acta Neuropathol. 2018 Apr 11. pii: 10.1007/s00401-018-1845.
    PubMed     Abstract available


  67. KATZ LM, Hielscher T, Liechty B, Silverman J, et al
    Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence.
    Acta Neuropathol. 2018 Apr 7. pii: 10.1007/s00401-018-1844.
    PubMed     Abstract available


  68. BARTHEL FP, Wesseling P, Verhaak RGW
    Reconstructing the molecular life history of gliomas.
    Acta Neuropathol. 2018 Apr 3. pii: 10.1007/s00401-018-1842.
    PubMed     Abstract available


    March 2018
  69. KORSHUNOV A, Sahm F, Stichel D, Schrimpf D, et al
    Molecular characterization of medulloblastomas with extensive nodularity (MBEN).
    Acta Neuropathol. 2018 Mar 22. pii: 10.1007/s00401-018-1840.
    PubMed     Abstract available


  70. REINHARDT A, Stichel D, Schrimpf D, Sahm F, et al
    Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations.
    Acta Neuropathol. 2018 Mar 21. pii: 10.1007/s00401-018-1837.
    PubMed     Abstract available


  71. NEIDERT MC, Kowalewski DJ, Silginer M, Kapolou K, et al
    The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy.
    Acta Neuropathol. 2018 Mar 20. pii: 10.1007/s00401-018-1836.
    PubMed     Abstract available


  72. APPS JR, Carreno G, Gonzalez-Meljem JM, Haston S, et al
    Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target.
    Acta Neuropathol. 2018 Mar 14. pii: 10.1007/s00401-018-1830.
    PubMed     Abstract available


  73. LOUIS DN, Giannini C, Capper D, Paulus W, et al
    cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant.
    Acta Neuropathol. 2018 Mar 1. pii: 10.1007/s00401-018-1826.
    PubMed    


    February 2018
  74. LABRECHE K, Kinnersley B, Berzero G, Di Stefano AL, et al
    Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci.
    Acta Neuropathol. 2018 Feb 19. pii: 10.1007/s00401-018-1825.
    PubMed     Abstract available


  75. IORGULESCU JB, Van Ziffle J, Stevers M, Grenert JP, et al
    Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.
    Acta Neuropathol. 2018 Feb 12. pii: 10.1007/s00401-018-1819.
    PubMed    


  76. GLOWACKA WK, Jain H, Okura M, Maimaitiming A, et al
    5-Hydroxymethylcytosine preferentially targets genes upregulated in isocitrate dehydrogenase 1 mutant high-grade glioma.
    Acta Neuropathol. 2018 Feb 10. pii: 10.1007/s00401-018-1821.
    PubMed     Abstract available


    January 2018
  77. BADY P, Kurscheid S, Delorenzi M, Gorlia T, et al
    The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033.
    Acta Neuropathol. 2018 Jan 24. pii: 10.1007/s00401-018-1810.
    PubMed     Abstract available


  78. MUSTAFA DAM, Pedrosa RMSM, Smid M, van der Weiden M, et al
    T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression.
    Acta Neuropathol. 2018 Jan 19. pii: 10.1007/s00401-018-1806.
    PubMed     Abstract available


  79. PRATT D, Natarajan SK, Banda A, Giannini C, et al
    Circumscribed/non-diffuse histology confers a better prognosis in H3K27M-mutant gliomas.
    Acta Neuropathol. 2018 Jan 4. pii: 10.1007/s00401-018-1805.
    PubMed    


    November 2017
  80. BOGEAS A, Morvan-Dubois G, El-Habr EA, Lejeune FX, et al
    Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness.
    Acta Neuropathol. 2017 Nov 17. doi: 10.1007/s00401-017-1783.
    PubMed     Abstract available


  81. HASSELBLATT M, Johann PD, Kool M, Fruhwald MC, et al
    Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome.
    Acta Neuropathol. 2017;134:817-818.
    PubMed    


  82. PANWALKAR P, Clark J, Ramaswamy V, Hawes D, et al
    Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome.
    Acta Neuropathol. 2017;134:705-714.
    PubMed     Abstract available


    October 2017
  83. LOPEZ GY, Oberheim Bush NA, Phillips JJ, Bouffard JP, et al
    Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression.
    Acta Neuropathol. 2017 Oct 23. doi: 10.1007/s00401-017-1780.
    PubMed    


  84. WIJNENGA MMJ, Dubbink HJ, French PJ, Synhaeve NE, et al
    Molecular and clinical heterogeneity of adult diffuse low-grade IDH wild-type gliomas: assessment of TERT promoter mutation and chromosome 7 and 10 copy number status allows superior prognostic stratification.
    Acta Neuropathol. 2017 Oct 19. doi: 10.1007/s00401-017-1781.
    PubMed    


  85. BEYER U, Brand F, Martens H, Weder J, et al
    Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis.
    Acta Neuropathol. 2017 Oct 13. doi: 10.1007/s00401-017-1774.
    PubMed     Abstract available


  86. KORSHUNOV A, Chavez L, Northcott PA, Sharma T, et al
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