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  Neoplasms of the CNS

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Articles published in Acta Neuropathol

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Single Articles


    June 2024
  1. OKONECHNIKOV K, Schrimpf D, Koster J, Sievers P, et al
    Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations.
    Acta Neuropathol. 2024;147:95.
    PubMed     Abstract available


    May 2024
  2. LIN AL, Rudneva VA, Richards AL, Zhang Y, et al
    Genome-wide loss of heterozygosity predicts aggressive, treatment-refractory behavior in pituitary neuroendocrine tumors.
    Acta Neuropathol. 2024;147:85.
    PubMed     Abstract available


  3. SCHULLER U, Gocke A, Godbole S, Delbridge C, et al
    Anaplastic histology and distinct molecular features in a small series of spinal cord ependymomas.
    Acta Neuropathol. 2024;147:83.
    PubMed    


    April 2024
  4. NASSIRI F, Ajisebutu A, Patil V, Mamatjan Y, et al
    Metabologenomic characterization uncovers a clinically aggressive IDH mutant glioma subtype.
    Acta Neuropathol. 2024;147:68.
    PubMed     Abstract available


    March 2024
  5. REDMER T, Schumann E, Peters K, Weidemeier ME, et al
    Correction to: MET receptor serves as a promising target in melanoma brain metastases.
    Acta Neuropathol. 2024;147:63.
    PubMed    


  6. ZAKIMI N, Nguyen MP, Raleigh DR
    Gene transcript fusions are associated with clinical outcomes and molecular groups of meningiomas.
    Acta Neuropathol. 2024;147:57.
    PubMed    


    February 2024
  7. REDMER T, Schumann E, Peters K, Weidemeier ME, et al
    MET receptor serves as a promising target in melanoma brain metastases.
    Acta Neuropathol. 2024;147:44.
    PubMed     Abstract available


  8. HARMANCI AS, Boudreau B, Lau S, Hosseingholi Nouri S, et al
    Aggressive human MenG C meningiomas have a molecular counterpart in canines.
    Acta Neuropathol. 2024;147:42.
    PubMed    


  9. ZAKIMI N, Mazcko CN, Toedebusch C, Tawa G, et al
    Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas.
    Acta Neuropathol. 2024;147:43.
    PubMed    


  10. RAHMANZADE R, Sahm F
    Reply: pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion.
    Acta Neuropathol. 2024;147:35.
    PubMed    


  11. VASILJEVIC A
    Pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion. Scientific commentary on 'Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate diffe
    Acta Neuropathol. 2024;147:34.
    PubMed    


    January 2024
  12. NEYAZI S, Yamazawa E, Hack K, Tanaka S, et al
    Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation.
    Acta Neuropathol. 2024;147:22.
    PubMed     Abstract available


  13. DREXLER R, Khatri R, Schuller U, Eckhardt A, et al
    Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma.
    Acta Neuropathol. 2024;147:21.
    PubMed     Abstract available


  14. DOTTERMUSCH M, Ryba A, Ricklefs FL, Flitsch J, et al
    Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features.
    Acta Neuropathol. 2024;147:16.
    PubMed     Abstract available


    December 2023
  15. HADAD S, Gupta R, Oberheim Bush NA, Taylor JW, et al
    "De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
    Acta Neuropathol. 2023;147:3.
    PubMed     Abstract available


  16. AUFFRET L, Ajlil Y, Tauziede-Espariat A, Kergrohen T, et al
    A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation.
    Acta Neuropathol. 2023;147:2.
    PubMed     Abstract available


  17. HICKMAN RA, Gedvilaite E, Ptashkin R, Reiner AS, et al
    CDKN2A/B mutations and allele-specific alterations stratify survival outcomes in IDH-mutant astrocytomas.
    Acta Neuropathol. 2023;146:845-847.
    PubMed    


  18. RAHMANZADE R, Pfaff E, Banan R, Sievers P, et al
    Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics.
    Acta Neuropathol. 2023;146:853-856.
    PubMed    


    October 2023
  19. MAAS SLN, Sievers P, Weber DC, Weller M, et al
    Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042-26042.
    Acta Neuropathol. 2023 Oct 19. doi: 10.1007/s00401-023-02642.
    PubMed    


  20. ROBERTS HJ, Ji S, Picca A, Sanson M, et al
    Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations.
    Acta Neuropathol. 2023 Oct 18. doi: 10.1007/s00401-023-02640.
    PubMed    


  21. PICARD D, Felsberg J, Langini M, Stachura P, et al
    Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma.
    Acta Neuropathol. 2023;146:551-564.
    PubMed     Abstract available


    September 2023
  22. BOETTO J, Plu I, Ducos Y, Blouin A, et al
    Normal meninges harbor oncogenic somatic mutations in meningioma-driver genes.
    Acta Neuropathol. 2023 Sep 26. doi: 10.1007/s00401-023-02635.
    PubMed    


  23. TRAN QT, Upadhyaya SA, Billups CA, Onar-Thomas A, et al
    DNA-methylation subgroups carry no prognostic significance in ATRT-SHH patients in clinical trial cohorts.
    Acta Neuropathol. 2023;146:543-545.
    PubMed    


  24. JOHANN PD, Altendorf L, Efremova EM, Holsten T, et al
    Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics.
    Acta Neuropathol. 2023;146:527-541.
    PubMed     Abstract available


    August 2023
  25. WIRSCHING HG, Felsberg J, Prummer M, Moisoiu V, et al
    Spatial immune profiling of glioblastoma identifies an inflammatory, perivascular phenotype associated with longer survival.
    Acta Neuropathol. 2023 Aug 13. doi: 10.1007/s00401-023-02617.
    PubMed    


    July 2023
  26. WILLIAMS EA, Brastianos PK, Wakimoto H, Zolal A, et al
    A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4.
    Acta Neuropathol. 2023 Jul 31. doi: 10.1007/s00401-023-02609.
    PubMed     Abstract available


    June 2023
  27. MEDICI G, Freudenmann LK, Velz J, Wang SS, et al
    A T-cell antigen atlas for meningioma: novel options for immunotherapy.
    Acta Neuropathol. 2023 Jun 27. doi: 10.1007/s00401-023-02605.
    PubMed     Abstract available


  28. MADLENER S, Furtner J, Stepien N, Senfter D, et al
    Clinical applicability of miR517a detection in liquid biopsies of ETMR patients.
    Acta Neuropathol. 2023;145:843-846.
    PubMed    


    May 2023
  29. WANG JZ, Patil V, Liu J, Dogan H, et al
    Correction: Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas.
    Acta Neuropathol. 2023 May 12. doi: 10.1007/s00401-023-02584.
    PubMed    


    April 2023
  30. KORSHUNOV A, Okonechnikov K, Schrimpf D, Tonn S, et al
    Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes.
    Acta Neuropathol. 2023 Apr 24. doi: 10.1007/s00401-023-02575.
    PubMed     Abstract available


  31. WANG JZ, Patil V, Liu J, Dogan H, et al
    Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas.
    Acta Neuropathol. 2023 Apr 24. doi: 10.1007/s00401-023-02571.
    PubMed     Abstract available


  32. GODDARD J, Castle J, Southworth E, Fletcher A, et al
    Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification.
    Acta Neuropathol. 2023 Apr 4. doi: 10.1007/s00401-023-02566.
    PubMed     Abstract available


    March 2023
  33. BOGUMIL H, Sill M, Schrimpf D, Ismer B, et al
    Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.
    Acta Neuropathol. 2023 Mar 18. doi: 10.1007/s00401-023-02558.
    PubMed     Abstract available


  34. JAMSHIDI P, McCord M, Galbraith K, Santana-Santos L, et al
    Variant allelic frequency of driver mutations predicts success of genomic DNA methylation classification in central nervous system tumors.
    Acta Neuropathol. 2023;145:365-367.
    PubMed    


    February 2023
  35. KHAN AB, English CW, Chen WC, Athukuri P, et al
    Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma.
    Acta Neuropathol. 2023 Feb 2. doi: 10.1007/s00401-023-02543.
    PubMed    


  36. TANG V, Lu R, Mirchia K, Van Ziffle J, et al
    Loss of p16 expression is a sensitive marker of CDKN2A homozygous deletion in malignant meningiomas.
    Acta Neuropathol. 2023 Feb 1. doi: 10.1007/s00401-023-02544.
    PubMed    


    January 2023
  37. KECK MK, Sill M, Wittmann A, Joshi P, et al
    Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
    Acta Neuropathol. 2023;145:49-69.
    PubMed     Abstract available


  38. CIMINO PJ, Ketchum C, Turakulov R, Singh O, et al
    Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1.
    Acta Neuropathol. 2023;145:71-82.
    PubMed     Abstract available


  39. METAIS A, Bouchoucha Y, Kergrohen T, Dangouloff-Ros V, et al
    Pediatric spinal pilocytic astrocytomas form a distinct epigenetic subclass from pilocytic astrocytomas of other locations and diffuse leptomeningeal glioneuronal tumours.
    Acta Neuropathol. 2023;145:83-95.
    PubMed     Abstract available


    December 2022
  40. EBRAHIMI A, Herrlinger U, Waha A, Kaluza L, et al
    Methylation class oligosarcoma may encompass IDH-wildtype gliomas.
    Acta Neuropathol. 2022 Dec 15. doi: 10.1007/s00401-022-02529.
    PubMed    


  41. MYNAREK M, Obrecht D, Sill M, Sturm D, et al
    Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts.
    Acta Neuropathol. 2022 Dec 2. doi: 10.1007/s00401-022-02522.
    PubMed     Abstract available


  42. CHIANG J, Moreira DC, Li X, Furtado LV, et al
    Prognostic significance of chromosome arm 1q gain and methylation class in molecularly defined diffuse leptomeningeal glioneuronal tumor.
    Acta Neuropathol. 2022;144:1185-1187.
    PubMed    


  43. TAUZIEDE-ESPARIAT A, Volodia-Dangouloff-Ros, Figarella-Branger D, Uro-Coste E, et al
    Clinicopathological and molecular characterization of three cases classified by DNA-methylation profiling as "Glioneuronal Tumors, NOS, Subtype A".
    Acta Neuropathol. 2022;144:1179-1183.
    PubMed    


    November 2022
  44. GOTTARDO NG
    Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas: "it's a numbers game"-implications for WNT medulloblastoma dose-reduction clinical trials.
    Acta Neuropathol. 2022 Nov 20. doi: 10.1007/s00401-022-02518.
    PubMed    


    October 2022
  45. WU Z, Rajan S, Chung HJ, Raffeld M, et al
    Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions.
    Acta Neuropathol. 2022 Oct 6. pii: 10.1007/s00401-022-02508.
    PubMed    


  46. LIU APY, Dhanda SK, Lin T, Sioson E, et al
    Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children's Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials.
    Acta Neuropathol. 2022;144:733-746.
    PubMed     Abstract available


  47. MESSIAEN J, Claeys A, Shetty A, Spans L, et al
    Generation of patient-derived models from a metastatic pediatric diffuse leptomeningeal glioneuronal tumor with KIAA1549::BRAF fusion.
    Acta Neuropathol. 2022;144:793-797.
    PubMed    


  48. GOSCHZIK T, Mynarek M, Doerner E, Schenk A, et al
    Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas.
    Acta Neuropathol. 2022 Oct 1. pii: 10.1007/s00401-022-02505.
    PubMed     Abstract available


    September 2022
  49. TATARI N, Khan S, Livingstone J, Zhai K, et al
    The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers.
    Acta Neuropathol. 2022 Sep 30. pii: 10.1007/s00401-022-02506.
    PubMed     Abstract available


  50. RICKLEFS FL, Fita KD, Mohme M, Mawrin C, et al
    Genetic and epigenetic profiling identifies two distinct classes of spinal meningiomas.
    Acta Neuropathol. 2022 Sep 27. pii: 10.1007/s00401-022-02504.
    PubMed    


  51. SIDDAWAY R, Canty L, Pajovic S, Milos S, et al
    Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma.
    Acta Neuropathol. 2022 Sep 7. pii: 10.1007/s00401-022-02489.
    PubMed     Abstract available


    August 2022
  52. DOGAN H, Blume C, Patel A, Jungwirth G, et al
    Single-cell DNA sequencing reveals order of mutational acquisition in TRAF7/AKT1 and TRAF7/KLF4 mutant meningiomas.
    Acta Neuropathol. 2022 Aug 19. pii: 10.1007/s00401-022-02485.
    PubMed    


  53. LUCAS CG, Sloan EA, Gupta R, Wu J, et al
    Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.
    Acta Neuropathol. 2022 Aug 9. pii: 10.1007/s00401-022-02478.
    PubMed     Abstract available


  54. HUA L, Alkhatib M, Podlesek D, Gunther L, et al
    Two predominant molecular subtypes of spinal meningioma: thoracic NF2-mutant tumors strongly associated with female sex, and cervical AKT1-mutant tumors originating ventral to the spinal cord.
    Acta Neuropathol. 2022 Aug 9. pii: 10.1007/s00401-022-02474.
    PubMed    


  55. PRATT D, Lucas CG, Selvam PP, Abdullaev Z, et al
    Recurrent ACVR1 mutations in posterior fossa ependymoma.
    Acta Neuropathol. 2022;144:373-376.
    PubMed    


    July 2022
  56. DANILENKO M, Zaka M, Keeling C, Crosier S, et al
    Single-cell DNA sequencing identifies risk-associated clonal complexity and evolutionary trajectories in childhood medulloblastoma development.
    Acta Neuropathol. 2022 Jul 13. pii: 10.1007/s00401-022-02464.
    PubMed     Abstract available


    June 2022
  57. KORSHUNOV A, Okonechnikov K, Stichel D, Schrimpf D, et al
    Gene expression profiling of Group 3 medulloblastomas defines a clinically tractable stratification based on KIRREL2 expression.
    Acta Neuropathol. 2022 Jun 30. pii: 10.1007/s00401-022-02460.
    PubMed     Abstract available


  58. VASUDEVAN HN, Choudhury A, Hilz S, Villanueva-Meyer JE, et al
    Intratumor and informatic heterogeneity influence meningioma molecular classification.
    Acta Neuropathol. 2022 Jun 27. pii: 10.1007/s00401-022-02455.
    PubMed    


  59. ADEBERG S, Knoll M, Koelsche C, Bernhardt D, et al
    DNA-methylome-assisted classification of patients with poor prognostic subventricular zone associated IDH-wildtype glioblastoma.
    Acta Neuropathol. 2022 Jun 4. pii: 10.1007/s00401-022-02443.
    PubMed     Abstract available


  60. FEDERICO A, Thomas C, Miskiewicz K, Woltering N, et al
    ATRT-SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance.
    Acta Neuropathol. 2022;143:697-711.
    PubMed     Abstract available


    May 2022
  61. WU Z, Lopes Abath Neto O, Bale TA, Benhamida J, et al
    DNA methylation analysis of glioblastomas harboring FGFR3-TACC3 fusions identifies a methylation subclass with better patient survival.
    Acta Neuropathol. 2022 May 14. pii: 10.1007/s00401-022-02430.
    PubMed    


  62. PATEL A, Dogan H, Payne A, Krause E, et al
    Rapid-CNS(2): rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study.
    Acta Neuropathol. 2022;143:609-612.
    PubMed    


    April 2022
  63. FLASCH DA, Chen X, Ju B, Li X, et al
    Somatic LINE-1 promoter acquisition drives oncogenic FOXR2 activation in pediatric brain tumor.
    Acta Neuropathol. 2022 Apr 11. pii: 10.1007/s00401-022-02420.
    PubMed    


  64. ROOSEN M, Ode Z, Bunt J, Kool M, et al
    The oncogenic fusion landscape in pediatric CNS neoplasms.
    Acta Neuropathol. 2022;143:427-451.
    PubMed     Abstract available


    March 2022
  65. LIU AP, Li KK, Chow C, Chan S, et al
    Expanding the clinical and molecular spectrum of pituitary blastoma.
    Acta Neuropathol. 2022;143:415-417.
    PubMed    


    February 2022
  66. TAUZIEDE-ESPARIAT A, Guerrini-Rousseau L, Perrier A, Torrejon J, et al
    Immunohistochemistry as a tool to identify ELP1-associated medulloblastoma.
    Acta Neuropathol. 2022 Feb 23. pii: 10.1007/s00401-022-02409.
    PubMed    


  67. PRATT D, Abdullaev Z, Papanicolau-Sengos A, Ketchum C, et al
    High-grade glioma with pleomorphic and pseudopapillary features (HPAP): a proposed type of circumscribed glioma in adults harboring frequent TP53 mutations and recurrent monosomy 13.
    Acta Neuropathol. 2022 Feb 1. pii: 10.1007/s00401-022-02404.
    PubMed     Abstract available


  68. SUWALA AK, Felix M, Friedel D, Stichel D, et al
    Oligosarcomas, IDH-mutant are distinct and aggressive.
    Acta Neuropathol. 2022;143:263-281.
    PubMed     Abstract available


    January 2022
  69. MARKWELL SM, Ross JL, Olson CL, Brat DJ, et al
    Necrotic reshaping of the glioma microenvironment drives disease progression.
    Acta Neuropathol. 2022 Jan 17. pii: 10.1007/s00401-021-02401.
    PubMed     Abstract available


  70. LUCAS CG, Gupta R, Wu J, Shah K, et al
    EWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma.
    Acta Neuropathol. 2022;143:109-113.
    PubMed    


  71. JENSEIT A, Camgoz A, Pfister SM, Kool M, et al
    EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma.
    Acta Neuropathol. 2022;143:1-13.
    PubMed     Abstract available


    December 2021
  72. LUCAS CG, Abdullaev Z, Bruggers CS, Mirchia K, et al
    Activating NTRK2 and ALK receptor tyrosine kinase fusions extend the molecular spectrum of pleomorphic xanthoastrocytomas of early childhood: a diagnostic overlap with infant-type hemispheric glioma.
    Acta Neuropathol. 2021 Dec 15. pii: 10.1007/s00401-021-02396.
    PubMed    


  73. CHONG AS, Han H, Albrecht S, Weon YC, et al
    DICER1 syndrome in a young adult with pituitary blastoma.
    Acta Neuropathol. 2021;142:1071-1076.
    PubMed    


  74. SCHMID S, Solomon DA, Perez E, Thieme A, et al
    Genetic and epigenetic characterization of posterior pituitary tumors.
    Acta Neuropathol. 2021;142:1025-1043.
    PubMed     Abstract available


    November 2021
  75. ALHALABI KT, Stichel D, Sievers P, Peterziel H, et al
    PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum.
    Acta Neuropathol. 2021;142:841-857.
    PubMed     Abstract available


  76. SIEVERS P, Henneken SC, Blume C, Sill M, et al
    Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors.
    Acta Neuropathol. 2021;142:827-839.
    PubMed     Abstract available


    September 2021
  77. SIEVERS P, Stichel D, Sill M, Schrimpf D, et al
    GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types.
    Acta Neuropathol. 2021 Sep 18. pii: 10.1007/s00401-021-02369.
    PubMed    


  78. KIRCHES E, Sahm F, Korshunov A, Bluecher C, et al
    Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas.
    Acta Neuropathol. 2021 Sep 8. pii: 10.1007/s00401-021-02351.
    PubMed     Abstract available


  79. GUPTA R, Lucas CG, Wu J, Barreto J, et al
    Low-grade glioneuronal tumors with FGFR2 fusion resolve into a single epigenetic group corresponding to 'Polymorphous low-grade neuroepithelial tumor of the young'.
    Acta Neuropathol. 2021;142:595-599.
    PubMed    


    August 2021
  80. COLTIN H, Sundaresan L, Smith KS, Skowron P, et al
    Subgroup and subtype-specific outcomes in adult medulloblastoma.
    Acta Neuropathol. 2021 Aug 18. pii: 10.1007/s00401-021-02358.
    PubMed     Abstract available


  81. LOTSCH D, Kirchhofer D, Englinger B, Jiang L, et al
    Targeting fibroblast growth factor receptors to combat aggressive ependymoma.
    Acta Neuropathol. 2021;142:339-360.
    PubMed     Abstract available


  82. PATHAK R, Zin F, Thomas C, Bens S, et al
    Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors.
    Acta Neuropathol. 2021;142:361-374.
    PubMed     Abstract available


    July 2021
  83. NAZIO F, Po A, Abballe L, Ballabio C, et al
    Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling.
    Acta Neuropathol. 2021 Jul 24. pii: 10.1007/s00401-021-02347.
    PubMed     Abstract available


  84. SCHOOF M, Kordes U, Volk AE, Al-Kershi S, et al
    Malignant gliomas with H3F3A G34R mutation or MYCN amplification in pediatric patients with Li Fraumeni syndrome.
    Acta Neuropathol. 2021 Jul 15. pii: 10.1007/s00401-021-02346.
    PubMed    


    June 2021
  85. FUJIMOTO K, Arita H, Satomi K, Yamasaki K, et al
    TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma.
    Acta Neuropathol. 2021 Jun 20. pii: 10.1007/s00401-021-02337.
    PubMed     Abstract available


  86. KRESBACH C, Dorostkar MM, Suwala AK, Wefers AK, et al
    Neurofibromatosis type 2 predisposes to ependymomas of various localization, histology, and molecular subtype.
    Acta Neuropathol. 2021;141:971-974.
    PubMed    


  87. THOMAS C, Thierfelder F, Trager M, Soschinski P, et al
    TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma.
    Acta Neuropathol. 2021;141:959-970.
    PubMed     Abstract available


  88. TESILEANU CMS, Vallentgoed WR, Sanson M, Taal W, et al
    Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations.
    Acta Neuropathol. 2021;141:945-957.
    PubMed     Abstract available


  89. NADAF J, de Kock L, Chong AS, Korbonits M, et al
    Molecular characterization of DICER1-mutated pituitary blastoma.
    Acta Neuropathol. 2021;141:929-944.
    PubMed     Abstract available


    May 2021
  90. JAUNMUKTANE Z, Banerjee G, Paine S, Parry-Jones A, et al
    Alzheimer's disease neuropathological change three decades after iatrogenic amyloid-beta transmission.
    Acta Neuropathol. 2021 May 28. pii: 10.1007/s00401-021-02326.
    PubMed    


  91. LIU APY, Li BK, Pfaff E, Gudenas B, et al
    Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.
    Acta Neuropathol. 2021;141:771-785.
    PubMed     Abstract available


    April 2021
  92. FORSTER A, Brand F, Banan R, Huneburg R, et al
    Rare germline variants in the E-cadherin gene CDH1 are associated with the risk of brain tumors of neuroepithelial and epithelial origin.
    Acta Neuropathol. 2021 Apr 30. pii: 10.1007/s00401-021-02307.
    PubMed     Abstract available


  93. SUWALA AK, Stichel D, Schrimpf D, Maas SLN, et al
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    Circular RNA profiling distinguishes medullobastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma.
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    March 2021
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    January 2021
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    December 2020
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    October 2020
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