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  Neoplasms of the CNS

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Articles published in Clin Cancer Res

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Single Articles


    November 2020
  1. IORGULESCU JB, Gokhale PC, Speranza MC, Eschle BK, et al
    Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma.
    Clin Cancer Res. 2020 Nov 25. pii: 1078-0432.CCR-20-2291.
    PubMed     Abstract available


  2. NAYAK L, Molinaro AM, Peters KB, Clarke JL, et al
    Randomized phase II and biomarker study of pembrolizumab plus bevacizumab versus pembrolizumab alone for recurrent glioblastoma patients.
    Clin Cancer Res. 2020 Nov 16. pii: 1078-0432.CCR-20-2500.
    PubMed     Abstract available


  3. VIGNESWARAN K, Boyd NH, Oh SY, Lallani S, et al
    YAP/TAZ transcriptional co-activators create therapeutic vulnerability to verteporfin in EGFR mutant glioblastoma.
    Clin Cancer Res. 2020 Nov 10. pii: 1078-0432.CCR-20-0018.
    PubMed     Abstract available


    October 2020
  4. ESTEVE-CODINA A, Alameda F, Carrato C, Pineda E, et al
    RNA-Sequencing and immunohistochemistry reveal ZFN7 as a stronger marker of survival than molecular subtypes in G-CIMP-negative glioblastoma.
    Clin Cancer Res. 2020 Oct 26. pii: 1078-0432.CCR-20-2141.
    PubMed     Abstract available


  5. BRUZEK AK, Ravi K, Muruganand A, Wadden J, et al
    Electronic DNA Analysis of CSF Cell-free Tumor DNA to Quantify Multi-gene Molecular Response in Pediatric High-grade Glioma.
    Clin Cancer Res. 2020 Oct 21. pii: 1078-0432.CCR-20-2066.
    PubMed     Abstract available


  6. MONTAY-GRUEL P, Acharya MM, Goncalves Jorge P, Petit B, et al
    Hypo-fractionated FLASH-RT as an effective treatment against glioblastoma that reduces neurocognitive side effects in mice.
    Clin Cancer Res. 2020 Oct 15. pii: 1078-0432.CCR-20-0894.
    PubMed     Abstract available


  7. MURALIDHARAN K, Yekula A, Small JL, Rosh ZS, et al
    TERT promoter mutation analysis for blood-based diagnosis and monitoring of gliomas.
    Clin Cancer Res. 2020 Oct 13. pii: 1078-0432.CCR-20-3083.
    PubMed     Abstract available


  8. PARK JE, Kim HS, Kim N, Park SY, et al
    Spatiotemporal Heterogeneity in Multiparametric Physiologic MRI Are Associated with Patient Outcomes in IDH-wildtype Glioblastoma.
    Clin Cancer Res. 2020 Oct 7. pii: 1078-0432.CCR-20-2156.
    PubMed     Abstract available


    September 2020
  9. CARRATO C, Alameda F, Esteve-Codina A, Pineda E, et al
    Glioblastoma TCGA mesenchymal and IGS 23 tumors are identifiable by immunohistochemistry and have an immune-phenotype indicating potential benefit from immunotherapy.
    Clin Cancer Res. 2020 Sep 30. pii: 1078-0432.CCR-20-2171.
    PubMed     Abstract available


  10. WIRSCHING HG, Roelcke U, Weller J, Hundsberger T, et al
    MRI and 18FET-PET predict survival benefit from bevacizumab plus radiotherapy in patients with IDH wild-type glioblastoma: results from the randomized ARTE trial.
    Clin Cancer Res. 2020 Sep 23. pii: 1078-0432.CCR-20-2096.
    PubMed     Abstract available


  11. FERREIRA S, Foray C, Gatto A, Larcher M, et al
    AsiDNA is a radiosensitizer with no added toxicity in medulloblastoma pediatric models.
    Clin Cancer Res. 2020 Sep 8. pii: 1078-0432.CCR-20-1729.
    PubMed     Abstract available


    August 2020
  12. ACCOMANDO WP, Rao AR, Hogan DJ, Newman AM, et al
    Molecular and immunological signatures are related to clinical benefit from treatment with Vocimagene amiretrorepvec (Toca 511) and 5-fluorocytosine (Toca FC) in patients with glioma.
    Clin Cancer Res. 2020 Aug 18. pii: 1078-0432.CCR-20-0536.
    PubMed     Abstract available


  13. WILDES TJ, Dyson KA, Francis CP, Wummer BM, et al
    Immune escape after adoptive T cell therapy for malignant gliomas.
    Clin Cancer Res. 2020 Aug 11. pii: 1078-0432.CCR-20-1065.
    PubMed     Abstract available


    July 2020
  14. BATICH KA, Mitchell DA, Healy P, Herndon JE, et al
    Once, Twice, Three Times a Finding: Reproducibility of Dendritic Cell Vaccine Trials Targeting Cytomegalovirus in Glioblastoma.
    Clin Cancer Res. 2020 Jul 27. pii: 1078-0432.CCR-20-1082.
    PubMed     Abstract available


  15. TOLANEY SM, Sahebjam S, Le Rhun E, Bachelot T, et al
    A Phase 2 Study of Abemaciclib in Patients with Brain Metastases Secondary to Hormone Receptor Positive Breast Cancer.
    Clin Cancer Res. 2020 Jul 21. pii: 1078-0432.CCR-20-1764.
    PubMed     Abstract available


  16. YE Z, Price RL, Liu X, Lin J, et al
    Diffusion Histology Imaging Combining Diffusion Basis Spectrum Imaging (DBSI) and Machine Learning Improves Detection and Classification of Glioblastoma Pathology.
    Clin Cancer Res. 2020 Jul 21. pii: 1078-0432.CCR-20-0736.
    PubMed     Abstract available


    June 2020
  17. OTT M, Kassab C, Marisetty A, Hashimoto Y, et al
    Radiation with STAT3 blockade triggers dendritic cell-T cell interactions in the glioma microenvironment and therapeutic efficacy.
    Clin Cancer Res. 2020 Jun 30. pii: 1078-0432.CCR-19-4092.
    PubMed     Abstract available


  18. RAO G, Latha K, Ott M, Sabbagh A, et al
    Anti-PD-1 induces M1 polarization in the glioma microenvironment and exerts therapeutic efficacy in the absence of CD8 cytotoxic T cells.
    Clin Cancer Res. 2020 Jun 18. pii: 1078-0432.CCR-19-4110.
    PubMed     Abstract available


  19. LADOMERSKY E, Zhai L, Lauing KL, Bell A, et al
    Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma.
    Clin Cancer Res. 2020 Jun 16. pii: 1078-0432.CCR-19-3874.
    PubMed     Abstract available


  20. KHASRAW M, Reardon DA, Weller M, Sampson JH, et al
    PD-1 inhibitors: Do they have a future in the treatment of glioblastoma?
    Clin Cancer Res. 2020 Jun 11. pii: 1078-0432.CCR-20-1135.
    PubMed     Abstract available


  21. INDRACCOLO S, De Salvo GL, Verza M, Caccese M, et al
    Phosphorylated Acetyl-CoA Carboxylase is associated with clinical benefit with Regorafenib in relapsed glioblastoma: REGOMA Trial Biomarker Analysis.
    Clin Cancer Res. 2020 Jun 9. pii: 1078-0432.CCR-19-4055.
    PubMed     Abstract available


    May 2020
  22. SCHEETZ L, Kadiyala P, Sun X, Son S, et al
    Synthetic high-density lipoprotein nanodiscs for personalized immunotherapy against gliomas.
    Clin Cancer Res. 2020 May 21. pii: 1078-0432.CCR-20-0341.
    PubMed     Abstract available


  23. KANE JR, Zhao J, Tsujiuchi T, Laffleur B, et al
    CD8(+) T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas.
    Clin Cancer Res. 2020 May 19. pii: 1078-0432.CCR-19-3104.
    PubMed     Abstract available


  24. STRAGLIOTTO G, Pantalone MR, Rahbar A, Bartek J, et al
    Valganciclovir as add-on to standard therapy in glioblastoma patients.
    Clin Cancer Res. 2020 May 18. pii: 1078-0432.CCR-20-0369.
    PubMed     Abstract available


  25. BAGLEY SJ, Carpenter EL
    Plasma cfDNA in Glioblastoma-Response.
    Clin Cancer Res. 2020;26:2276.
    PubMed    


  26. TAKAYASU T, Esquenazi Y, Ballester LY
    Plasma cfDNA in Glioblastoma-Letter.
    Clin Cancer Res. 2020;26:2275.
    PubMed    


    April 2020
  27. EGUREN-SANTAMARIA I, Sanmamed MF, Goldberg SB, Kluger HM, et al
    PD-1/PD-L1 blockers in NSCLC brain metastases: challenging paradigms and clinical practice.
    Clin Cancer Res. 2020 Apr 30. pii: 1078-0432.CCR-20-0798.
    PubMed     Abstract available


  28. MENDEZ F, Kadiyala P, Nunez FJ, Carney S, et al
    Therapeutic efficacy of immune stimulatory thymidine kinase and fms-like tyrosine kinase 3 ligand (TK/Flt3L) gene therapy in a mouse model of high grade brainstem glioma.
    Clin Cancer Res. 2020 Apr 24. pii: 1078-0432.CCR-19-3714.
    PubMed     Abstract available


  29. LEE JH, Menzies AM, Carlino MS, McEvoy AC, et al
    Longitudinal monitoring of ctDNA in patients with melanoma and brain metastases treated with immune checkpoint inhibitors.
    Clin Cancer Res. 2020 Apr 22. pii: 1078-0432.CCR-19-3926.
    PubMed     Abstract available


  30. WEATHERS SP, Penas-Prado M, Pei BL, Ling X, et al
    Glioblastoma-mediated immune dysfunction limits CMV-specific T cells and therapeutic responses; results from a Phase I/II trial.
    Clin Cancer Res. 2020 Apr 16. pii: 1078-0432.CCR-20-0176.
    PubMed     Abstract available


  31. LAWLER SE, Chiocca EA, Cook CH
    Cytomegalovirus encephalopathy during brain tumor irradiation.
    Clin Cancer Res. 2020 Apr 10. pii: 1078-0432.CCR-20-0646.
    PubMed     Abstract available


  32. ELLINGSON BM, Yao J, Raymond C, Nathanson DA, et al
    Multi-parametric MR-PET imaging predicts pharmacokinetics and clinical response to GDC-0084 in patients with recurrent high-grade glioma.
    Clin Cancer Res. 2020 Apr 8. pii: 1078-0432.CCR-19-3817.
    PubMed     Abstract available


    March 2020
  33. MEEL MH, de Gooijer MC, Metselaar DS, Sewing ACP, et al
    Combined therapy of AXL and HDAC inhibition reverses mesenchymal transition in diffuse intrinsic pontine glioma.
    Clin Cancer Res. 2020 Mar 12. pii: 1078-0432.CCR-19-3538.
    PubMed     Abstract available


  34. OTANI Y, Yoo JY, Chao S, Liu J, et al
    Oncolytic HSV infected glioma cells activate NOTCH in adjacent tumor cells sensitizing tumors to gamma secretase inhibition.
    Clin Cancer Res. 2020 Mar 5. pii: 1078-0432.CCR-19-3420.
    PubMed     Abstract available


  35. KINSLOW CJ, Canoll P, Cheng SK, Wang TJC, et al
    Misclassification of Diffuse Gliomas-Letter.
    Clin Cancer Res. 2020;26:1198.
    PubMed    


    February 2020
  36. BEIG N, Bera K, Prasanna P, Antunes J, et al
    Radiogenomic-Based Survival Risk Stratification of Tumor Habitat on Gd-T1w MRI Is Associated with Biological Processes in Glioblastoma.
    Clin Cancer Res. 2020 Feb 20. pii: 1078-0432.CCR-19-2556.
    PubMed     Abstract available


  37. PIROVANO G, Jannetti SA, Carter LM, Sadique A, et al
    Targeted brain tumor radiotherapy using an Auger emitter.
    Clin Cancer Res. 2020 Feb 17. pii: 1078-0432.CCR-19-2440.
    PubMed     Abstract available


  38. VAZQUEZ-BORREGO MC, Gupta V, Ibanez-Costa A, Gahete MD, et al
    A Somatostatin Receptor Subtype-3 (SST3) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors.
    Clin Cancer Res. 2020;26:957-969.
    PubMed     Abstract available


  39. DIRKS PB, Gilbert MR, Holland EC, Maher EA, et al
    Translating basic science discoveries into improved outcomes for glioblastoma.
    Clin Cancer Res. 2020 Feb 14. pii: 1078-0432.CCR-19-3924.
    PubMed     Abstract available


  40. WICK W, Wagener RJ
    Not yet another negative trial - ReACTing on recent glioblastoma trials!
    Clin Cancer Res. 2020 Feb 7. pii: 1078-0432.CCR-19-4032.
    PubMed     Abstract available


  41. REARDON DA, Desjardins A, Vredenburgh JJ, O'Rourke DM, et al
    Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial.
    Clin Cancer Res. 2020 Feb 7. pii: 1078-0432.CCR-18-1140.
    PubMed     Abstract available


  42. ZHANG IY, Zhou H, Liu H, Zhang L, et al
    Local and Systemic Immune Dysregulation Alters Glioma Growth in Hyperglycemic Mice.
    Clin Cancer Res. 2020 Feb 4. pii: 1078-0432.CCR-19-2520.
    PubMed     Abstract available


  43. TANG B, Guo ZS, Bartlett DL, Yan DZ, et al
    Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma.
    Clin Cancer Res. 2020 Feb 4. pii: 1078-0432.CCR-18-3626.
    PubMed     Abstract available


  44. PASSARO C, Alayo Q, DeLaura I, McNulty J, et al
    Correction: Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy.
    Clin Cancer Res. 2020;26:758.
    PubMed    


    January 2020
  45. MOHME M, Maire CL, Geumann U, Schliffke S, et al
    Local intracerebral immunomodulation using interleukin-expressing mesenchymal stem cells in glioblastoma.
    Clin Cancer Res. 2020 Jan 27. pii: 1078-0432.CCR-19-0803.
    PubMed     Abstract available


  46. KUMTHEKAR P, Tang SC, Brenner AJ, Kesari S, et al
    ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases.
    Clin Cancer Res. 2020 Jan 22. pii: 1078-0432.CCR-19-3258.
    PubMed     Abstract available


  47. GRAILLON T, Sanson M, Campello C, Idbaih A, et al
    Everolimus and Octreotide for Patients with Recurrent Meningioma: Results from the Phase II CEVOREM Trial.
    Clin Cancer Res. 2020 Jan 22. pii: 1078-0432.CCR-19-2109.
    PubMed     Abstract available


  48. NASSIRI F, Taslimi S, Wang JZ, Badhiwala JH, et al
    Determining the optimal adjuvant therapy for improving survival in elderly patients with glioblastoma: a systematic review and meta-analysis.
    Clin Cancer Res. 2020 Jan 17. pii: 1078-0432.CCR-19-3359.
    PubMed     Abstract available


  49. POCHA K, Mock A, Rapp C, Dettling S, et al
    Surfactant expression defines an inflamed subtype of lung adenocarcinoma brain metastases that correlates with prolonged survival.
    Clin Cancer Res. 2020 Jan 17. pii: 1078-0432.CCR-19-2184.
    PubMed     Abstract available


  50. WEN PY, Cloughesy TF, Olivero AG, Morrissey KM, et al
    First-in-human Phase I study to evaluate the brain-penetrant PI3K/mTOR inhibitor GDC-0084 in patients with progressive or recurrent high-grade glioma.
    Clin Cancer Res. 2020 Jan 14. pii: 1078-0432.CCR-19-2808.
    PubMed     Abstract available


  51. RODRIGUEZ GUTIERREZ D, Jones C, Varlet P, Mackay A, et al
    Radiological evaluation of newly diagnosed non-brainstem pediatric high-grade glioma in the HERBY phase II trial.
    Clin Cancer Res. 2020 Jan 10. pii: 1078-0432.CCR-19-3154.
    PubMed     Abstract available


  52. TU Y, Chen Z, Zhao P, Sun G, et al
    Smoothened promotes glioblastoma radiation resistance via activating USP3-mediated Claspin deubiquitination.
    Clin Cancer Res. 2020 Jan 3. pii: 1078-0432.CCR-19-1515.
    PubMed     Abstract available


  53. HIGUCHI F, Nagashima H, Ning J, Koerner MVA, et al
    Restoration of Temozolomide Sensitivity by Poly(ADP-Ribose) Polymerase inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair.
    Clin Cancer Res. 2020 Jan 3. pii: 1078-0432.CCR-19-2000.
    PubMed     Abstract available


    December 2019
  54. WORONIECKA KI, Rhodin KE, Dechant CA, Waibl Polania J, et al
    4-1BB Agonism Averts TIL Exhaustion and Licenses PD-1 Blockade in Glioblastoma and Other Intracranial Cancers.
    Clin Cancer Res. 2019 Dec 23. pii: 1078-0432.CCR-19-1068.
    PubMed     Abstract available


  55. WU S, Gao F, Zheng S, Zhang C, et al
    EGFR amplification induces increased DNA damage response and renders selective sensitivity to Talazoparib (PARP inhibitor) in glioblastoma.
    Clin Cancer Res. 2019 Dec 18. pii: 1078-0432.CCR-19-2549.
    PubMed     Abstract available


  56. VAUBEL RA, Tian S, Remonde D, Schroeder MA, et al
    Genomic and phenotypic characterization of a broad panel of patient derived xenografts reflects the diversity of glioblastoma.
    Clin Cancer Res. 2019 Dec 18. pii: 1078-0432.CCR-19-0909.
    PubMed     Abstract available


  57. ZHANG DY, Dmello C, Chen L, Arrieta VA, et al
    Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations.
    Clin Cancer Res. 2019 Dec 12. pii: 1078-0432.CCR-19-2182.
    PubMed     Abstract available


  58. HARGRAVE DR, Bouffet E, Tabori U, Broniscer A, et al
    Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study.
    Clin Cancer Res. 2019 Dec 6. pii: 1078-0432.CCR-19-2177.
    PubMed     Abstract available


  59. CAMPAGNE O, Zhong B, Nair S, Lin T, et al
    Exposure-Toxicity Association of Cyclophosphamide and Its Metabolites in Infants and Young Children with Primary Brain Tumors: Implications for Dosing.
    Clin Cancer Res. 2019 Dec 3. pii: 1078-0432.CCR-19-2685.
    PubMed     Abstract available


    October 2019
  60. BAGLEY S, Nabavizadeh SA, Mays J, Till JE, et al
    Clinical utility of plasma cell-free DNA in adult patients with newly diagnosed glioblastoma - a pilot prospective study.
    Clin Cancer Res. 2019 Oct 30. pii: 1078-0432.CCR-19-2533.
    PubMed     Abstract available


  61. PARADA CA, Osbun JW, Busald T, Karasozen Y, et al
    Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals Rb1 signaling as a Novel Mediator and Biomarker.
    Clin Cancer Res. 2019 Oct 15. pii: 1078-0432.CCR-18-0641.
    PubMed     Abstract available


    September 2019
  62. GERSTNER E, Emblem KE, Chang K, Vakulenko-Lagun B, et al
    Bevacizumab reduces permeability and concurrent temozolomide delivery in a subset of patients with recurrent glioblastoma.
    Clin Cancer Res. 2019 Sep 26. pii: 1078-0432.CCR-19-1739.
    PubMed     Abstract available


  63. VAN DER VOORT SR, Incekara F, Wijnenga MM, Kapsas G, et al
    Predicting the 1p/19q co-deletion status of presumed low grade glioma with an externally validated machine learning algorithm.
    Clin Cancer Res. 2019 Sep 23. pii: 1078-0432.CCR-19-1127.
    PubMed     Abstract available


  64. SHARIFI Z, Abdulkarim B, Meehan B, Rak J, et al
    Antitumor Activity of a Binary EGFR/DNA Targeting Strategy Overcomes Resistance of Glioblastoma Stem cells to Temozolomide.
    Clin Cancer Res. 2019 Sep 20. pii: 1078-0432.CCR-19-0955.
    PubMed     Abstract available


  65. THOMAS RP, Nagpal S, Iv M, Soltys SG, et al
    Macrophage Exclusion after Radiation Therapy (MERT): A First in Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma.
    Clin Cancer Res. 2019 Sep 19. pii: 1078-0432.CCR-19-1421.
    PubMed     Abstract available


  66. PAPACHRISTODOULOU A, Silginer M, Weller M, Schneider H, et al
    Therapeutic targeting of TGF-beta ligands in glioblastoma using novel antisense oligonucleotides reduces the growth of experimental gliomas.
    Clin Cancer Res. 2019 Sep 17. pii: 1078-0432.CCR-17-3024.
    PubMed     Abstract available


  67. JUTHANI R, Madajewski B, Yoo B, Zhang L, et al
    Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model.
    Clin Cancer Res. 2019 Sep 12. pii: 1078-0432.CCR-19-1834.
    PubMed     Abstract available


  68. CHAUVIN C, Joalland N, Perroteau J, Jarry U, et al
    NKG2D controls natural reactivity of Vgamma9Vdelta2 T lymphocytes against mesenchymal glioblastoma cells.
    Clin Cancer Res. 2019 Sep 10. pii: 1078-0432.CCR-19-0375.
    PubMed     Abstract available


  69. JI J, Xu R, Ding K, Bao G, et al
    Long noncoding RNA SChLAP1 forms a growth promoting complex with HNRNPL in human glioblastoma through stabilization of ACTN4 and activation of NF-kappaB signaling.
    Clin Cancer Res. 2019 Sep 6. pii: 1078-0432.CCR-19-0747.
    PubMed     Abstract available


  70. WERBROUCK C, Evangelista CCS, Lobon-Iglesias MJ, Barret E, et al
    TP53 pathway alterations drive radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG).
    Clin Cancer Res. 2019 Sep 3. pii: 1078-0432.CCR-19-0126.
    PubMed     Abstract available


  71. LI J, Xue Y, Wenger A, Sun Y, et al
    Individual Assignment of Adult Diffuse Gliomas into the EM/PM Molecular Subtypes Using a TaqMan Low-Density Array.
    Clin Cancer Res. 2019 Sep 3. pii: 1078-0432.CCR-19-0299.
    PubMed     Abstract available


    August 2019
  72. JIANG H, Shin DH, Nguyen TT, Fueyo J, et al
    Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas.
    Clin Cancer Res. 2019 Aug 27. pii: 1078-0432.CCR-19-0405.
    PubMed     Abstract available


  73. BODEKER KL, Allen BG, Smith MC, Monga V, et al
    First-in-human phase 1 clinical trial of pharmacological ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma.
    Clin Cancer Res. 2019 Aug 19. pii: 1078-0432.CCR-19-0594.
    PubMed     Abstract available


    July 2019
  74. WEN PY, Reardon DA, Armstrong TS, Phuphanich S, et al
    A Randomized Double-Blind Placebo-Controlled Phase 2 Trial Of Dendritic Cell Vaccine ICT-107 In Newly Diagnosed Patients With Glioblastoma.
    Clin Cancer Res. 2019 Jul 18. pii: 1078-0432.CCR-19-0261.
    PubMed     Abstract available


  75. JUAREZ-CHAMBI RM, Kut C, Rico-Jimenez JJ, Chaichana KL, et al
    AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography.
    Clin Cancer Res. 2019 Jul 17. pii: 1078-0432.CCR-19-0854.
    PubMed     Abstract available


  76. YANG ZJ, Du F, Yuelling LW, Lee EH, et al
    Leukotriene synthesis is critical for medulloblastoma progression.
    Clin Cancer Res. 2019 Jul 12. pii: 1078-0432.CCR-18-3549.
    PubMed     Abstract available


  77. TIEN AC, Li J, Bao X, DeRogatis A, et al
    A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort.
    Clin Cancer Res. 2019 Jul 8. pii: 1078-0432.CCR-19-0133.
    PubMed     Abstract available


  78. JONSSON P, Lin AL, Young RJ, DiStefano NM, et al
    Genomic correlates of disease progression and treatment response in prospectively characterized gliomas.
    Clin Cancer Res. 2019 Jul 1. pii: 1078-0432.CCR-19-0032.
    PubMed     Abstract available


    June 2019
  79. RAPP C, Dettling S, Liu F, Ull AT, et al
    Cytotoxic T-cells and their activation status are independent prognostic markers in meningiomas.
    Clin Cancer Res. 2019 Jun 21. pii: 1078-0432.CCR-19-0389.
    PubMed     Abstract available


  80. KATAGI H, Louis N, Unruh D, Sasaki T, et al
    Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma.
    Clin Cancer Res. 2019 Jun 21. pii: 1078-0432.CCR-18-3890.
    PubMed     Abstract available


  81. FECCI PE, Champion CD, Hoj J, McKernan C, et al
    The Evolving Modern Management of Brain Metastasis.
    Clin Cancer Res. 2019 Jun 18. pii: 1078-0432.CCR-18-1624.
    PubMed     Abstract available


    May 2019
  82. SMITH SJ, Tyler B, Gould TWA, Veal GJ, et al
    Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste.
    Clin Cancer Res. 2019 May 21. pii: 1078-0432.CCR-18-3850.
    PubMed     Abstract available


    April 2019
  83. COHEN JV, Sullivan RJ
    Developments in the space of new MAPK pathway inhibitors for BRAF-mutant melanoma.
    Clin Cancer Res. 2019 Apr 16. pii: 1078-0432.CCR-18-0836.
    PubMed     Abstract available


  84. MORIKAWA A, de Stanchina E, Pentsova E, Kemeny MM, et al
    Phase I study of intermittent high dose lapatinib alternating with capecitabine for HER2-positive breast cancer patients with central nervous system metastases.
    Clin Cancer Res. 2019 Apr 15. pii: 1078-0432.CCR-18-3502.
    PubMed     Abstract available


    March 2019
  85. IDBAIH A, Canney M, Belin L, Desseaux C, et al
    Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma.
    Clin Cancer Res. 2019 Mar 19. pii: 1078-0432.CCR-18-3643.
    PubMed     Abstract available


  86. LI H, Li J, Chen L, Qi S, et al
    HERC3-mediated SMAD7 ubiquitination degradation promotes autophagy-induced EMT and chemoresistance in glioblastoma.
    Clin Cancer Res. 2019 Mar 12. pii: 1078-0432.CCR-18-3791.
    PubMed     Abstract available


  87. LAMANO JB, Lamano JB, Li YD, DiDomenico JD, et al
    Glioblastoma-Derived IL-6 Induces Immunosuppressive Peripheral Myeloid Cell PD-L1 and Promotes Tumor Growth.
    Clin Cancer Res. 2019 Mar 1. pii: 1078-0432.CCR-18-2402.
    PubMed     Abstract available


    February 2019
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    Brain Tumor Micro-environment and Host State - Implications for Immunotherapy.
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    Comparison of Biomarker Assays for EGFR: Implications for Precision Medicine in Patients with Glioblastoma.
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    A Phase I study of pegylated arginine deiminase (pegargiminase), cisplatin and pemetrexed in argininosuccinate synthetase 1-deficient recurrent high-grade glioma.
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    The dual PI3K/mTOR-pathway inhibitor GDC-0084 achieves antitumor activity in PIK3CA-mutant breast cancer brain metastases.
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  92. ZHANG Q, Zhang Y, Chen Y, Qian J, et al
    A novel mTORC1/2 inhibitor (MTI-31) inhibits tumor growth, epithelial-mesenchymal transition, metastases and improves cancer immunity in preclinical lung cancer models.
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    Tissue 2-hydroxyglutarate as a biomarker for isocitrate dehydrogenase (IDH) mutations in gliomas.
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    Ultrasensitive immunoprofiling of plasma extracellular vesicles identifies syndecan-1 as a potential tool for minimally invasive diagnosis of glioma.
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    L-Carnitine Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme.
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    YH25448, an irreversible EGFR-TKI with Potent Intracranial Activity in EGFR mutant non-small-cell lung cancer.
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    Immune Checkpoint Inhibitor-Induced Reinvigoration of Tumor-Infiltrating CD8(+) T Cells is Determined by Their Differentiation Status in Glioblastoma.
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    CAR T cells targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors.
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    Continued endocrine therapy is associated with improved survival in patients with breast cancer brain metastases.
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    VCAM-1-targeted MRI Enables Detection of Brain Micrometastases from Different Primary Tumors.
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    The Misclassification of Diffuse Gliomas: Rates and Outcomes.
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    Central Nervous System Metastasis in Patients With HER2-Positive Metastatic Breast Cancer: Patient Characteristics, Treatment, and Survival From SystHERs.
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    Genetic, epigenetic and immunologic profiling of MMR-deficient relapsed glioblastoma.
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    MGMT Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide. A Pooled Analysis of Four Clinical Trials.
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    November 2018
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    Expression of PD-1 by T cells in malignant glioma patients reflects exhaustion and activation.
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    Residual Tumor Volume, Cell Volume Fraction and Tumor Cell Kill During Fractionated Chemoradiation Therapy of Human Glioblastoma using Quantitative Sodium MR imaging.
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    A CK1alpha activator penetrates the brain, and shows efficacy against drug-resistant metastatic medulloblastoma.
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    Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy.
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    Ketoconazole and Posaconazole Selectively Target HK2 Expressing Glioblastoma Cells.
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    September 2018
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    August 2018
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    The oncometabolite D-2-hydroxyglutarate is an intercellular mediator in IDH-mutant gliomas that inhibits both complement and T cells.
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    Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-cell Targets in Human IDH-Mutant Glioma.
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    Toxicity and efficacy of a novel GADD34-expressing oncolytic HSV-1 for the treatment of experimental glioblastoma.
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    IDO1 inhibition synergizes with radiation and PD-1 blockade to durably increase survival against advanced glioblastoma.
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    Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX models.
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    Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes.
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