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  Neoplasms of the CNS

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Articles published in Clin Cancer Res

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    June 2020
  1. OTT M, Kassab C, Marisetty A, Hashimoto Y, et al
    Radiation with STAT3 blockade triggers dendritic cell-T cell interactions in the glioma microenvironment and therapeutic efficacy.
    Clin Cancer Res. 2020 Jun 30. pii: 1078-0432.CCR-19-4092.
    PubMed     Abstract available

  2. RAO G, Latha K, Ott M, Sabbagh A, et al
    Anti-PD-1 induces M1 polarization in the glioma microenvironment and exerts therapeutic efficacy in the absence of CD8 cytotoxic T cells.
    Clin Cancer Res. 2020 Jun 18. pii: 1078-0432.CCR-19-4110.
    PubMed     Abstract available

  3. LADOMERSKY E, Zhai L, Lauing KL, Bell A, et al
    Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma.
    Clin Cancer Res. 2020 Jun 16. pii: 1078-0432.CCR-19-3874.
    PubMed     Abstract available

  4. KHASRAW M, Reardon DA, Weller M, Sampson JH, et al
    PD-1 inhibitors: Do they have a future in the treatment of glioblastoma?
    Clin Cancer Res. 2020 Jun 11. pii: 1078-0432.CCR-20-1135.
    PubMed     Abstract available

  5. INDRACCOLO S, De Salvo GL, Verza M, Caccese M, et al
    Phosphorylated Acetyl-CoA Carboxylase is associated with clinical benefit with Regorafenib in relapsed glioblastoma: REGOMA Trial Biomarker Analysis.
    Clin Cancer Res. 2020 Jun 9. pii: 1078-0432.CCR-19-4055.
    PubMed     Abstract available

    May 2020
  6. SCHEETZ L, Kadiyala P, Sun X, Son S, et al
    Synthetic high-density lipoprotein nanodiscs for personalized immunotherapy against gliomas.
    Clin Cancer Res. 2020 May 21. pii: 1078-0432.CCR-20-0341.
    PubMed     Abstract available

  7. KANE JR, Zhao J, Tsujiuchi T, Laffleur B, et al
    CD8(+) T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas.
    Clin Cancer Res. 2020 May 19. pii: 1078-0432.CCR-19-3104.
    PubMed     Abstract available

  8. STRAGLIOTTO G, Pantalone MR, Rahbar A, Bartek J, et al
    Valganciclovir as add-on to standard therapy in glioblastoma patients.
    Clin Cancer Res. 2020 May 18. pii: 1078-0432.CCR-20-0369.
    PubMed     Abstract available

  9. BAGLEY SJ, Carpenter EL
    Plasma cfDNA in Glioblastoma-Response.
    Clin Cancer Res. 2020;26:2276.

  10. TAKAYASU T, Esquenazi Y, Ballester LY
    Plasma cfDNA in Glioblastoma-Letter.
    Clin Cancer Res. 2020;26:2275.

    April 2020
  11. EGUREN-SANTAMARIA I, Sanmamed MF, Goldberg SB, Kluger HM, et al
    PD-1/PD-L1 blockers in NSCLC brain metastases: challenging paradigms and clinical practice.
    Clin Cancer Res. 2020 Apr 30. pii: 1078-0432.CCR-20-0798.
    PubMed     Abstract available

  12. MENDEZ F, Kadiyala P, Nunez FJ, Carney S, et al
    Therapeutic efficacy of immune stimulatory thymidine kinase and fms-like tyrosine kinase 3 ligand (TK/Flt3L) gene therapy in a mouse model of high grade brainstem glioma.
    Clin Cancer Res. 2020 Apr 24. pii: 1078-0432.CCR-19-3714.
    PubMed     Abstract available

  13. LEE JH, Menzies AM, Carlino MS, McEvoy AC, et al
    Longitudinal monitoring of ctDNA in patients with melanoma and brain metastases treated with immune checkpoint inhibitors.
    Clin Cancer Res. 2020 Apr 22. pii: 1078-0432.CCR-19-3926.
    PubMed     Abstract available

  14. WEATHERS SP, Penas-Prado M, Pei BL, Ling X, et al
    Glioblastoma-mediated immune dysfunction limits CMV-specific T cells and therapeutic responses; results from a Phase I/II trial.
    Clin Cancer Res. 2020 Apr 16. pii: 1078-0432.CCR-20-0176.
    PubMed     Abstract available

  15. LAWLER SE, Chiocca EA, Cook CH
    Cytomegalovirus encephalopathy during brain tumor irradiation.
    Clin Cancer Res. 2020 Apr 10. pii: 1078-0432.CCR-20-0646.
    PubMed     Abstract available

  16. ELLINGSON BM, Yao J, Raymond C, Nathanson DA, et al
    Multi-parametric MR-PET imaging predicts pharmacokinetics and clinical response to GDC-0084 in patients with recurrent high-grade glioma.
    Clin Cancer Res. 2020 Apr 8. pii: 1078-0432.CCR-19-3817.
    PubMed     Abstract available

    March 2020
  17. MEEL MH, de Gooijer MC, Metselaar DS, Sewing ACP, et al
    Combined therapy of AXL and HDAC inhibition reverses mesenchymal transition in diffuse intrinsic pontine glioma.
    Clin Cancer Res. 2020 Mar 12. pii: 1078-0432.CCR-19-3538.
    PubMed     Abstract available

  18. OTANI Y, Yoo JY, Chao S, Liu J, et al
    Oncolytic HSV infected glioma cells activate NOTCH in adjacent tumor cells sensitizing tumors to gamma secretase inhibition.
    Clin Cancer Res. 2020 Mar 5. pii: 1078-0432.CCR-19-3420.
    PubMed     Abstract available

  19. KINSLOW CJ, Canoll P, Cheng SK, Wang TJC, et al
    Misclassification of Diffuse Gliomas-Letter.
    Clin Cancer Res. 2020;26:1198.

    February 2020
  20. BEIG N, Bera K, Prasanna P, Antunes J, et al
    Radiogenomic-Based Survival Risk Stratification of Tumor Habitat on Gd-T1w MRI Is Associated with Biological Processes in Glioblastoma.
    Clin Cancer Res. 2020 Feb 20. pii: 1078-0432.CCR-19-2556.
    PubMed     Abstract available

  21. PIROVANO G, Jannetti SA, Carter LM, Sadique A, et al
    Targeted brain tumor radiotherapy using an Auger emitter.
    Clin Cancer Res. 2020 Feb 17. pii: 1078-0432.CCR-19-2440.
    PubMed     Abstract available

  22. DIRKS PB, Gilbert MR, Holland EC, Maher EA, et al
    Translating basic science discoveries into improved outcomes for glioblastoma.
    Clin Cancer Res. 2020 Feb 14. pii: 1078-0432.CCR-19-3924.
    PubMed     Abstract available

  23. WICK W, Wagener RJ
    Not yet another negative trial - ReACTing on recent glioblastoma trials!
    Clin Cancer Res. 2020 Feb 7. pii: 1078-0432.CCR-19-4032.
    PubMed     Abstract available

  24. REARDON DA, Desjardins A, Vredenburgh JJ, O'Rourke DM, et al
    Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial.
    Clin Cancer Res. 2020 Feb 7. pii: 1078-0432.CCR-18-1140.
    PubMed     Abstract available

  25. ZHANG IY, Zhou H, Liu H, Zhang L, et al
    Local and Systemic Immune Dysregulation Alters Glioma Growth in Hyperglycemic Mice.
    Clin Cancer Res. 2020 Feb 4. pii: 1078-0432.CCR-19-2520.
    PubMed     Abstract available

  26. TANG B, Guo ZS, Bartlett DL, Yan DZ, et al
    Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma.
    Clin Cancer Res. 2020 Feb 4. pii: 1078-0432.CCR-18-3626.
    PubMed     Abstract available

  27. PASSARO C, Alayo Q, DeLaura I, McNulty J, et al
    Correction: Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy.
    Clin Cancer Res. 2020;26:758.

    January 2020
  28. MOHME M, Maire CL, Geumann U, Schliffke S, et al
    Local intracerebral immunomodulation using interleukin-expressing mesenchymal stem cells in glioblastoma.
    Clin Cancer Res. 2020 Jan 27. pii: 1078-0432.CCR-19-0803.
    PubMed     Abstract available

  29. KUMTHEKAR P, Tang SC, Brenner AJ, Kesari S, et al
    ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases.
    Clin Cancer Res. 2020 Jan 22. pii: 1078-0432.CCR-19-3258.
    PubMed     Abstract available

  30. GRAILLON T, Sanson M, Campello C, Idbaih A, et al
    Everolimus and Octreotide for Patients with Recurrent Meningioma: Results from the Phase II CEVOREM Trial.
    Clin Cancer Res. 2020 Jan 22. pii: 1078-0432.CCR-19-2109.
    PubMed     Abstract available

  31. NASSIRI F, Taslimi S, Wang JZ, Badhiwala JH, et al
    Determining the optimal adjuvant therapy for improving survival in elderly patients with glioblastoma: a systematic review and meta-analysis.
    Clin Cancer Res. 2020 Jan 17. pii: 1078-0432.CCR-19-3359.
    PubMed     Abstract available

  32. POCHA K, Mock A, Rapp C, Dettling S, et al
    Surfactant expression defines an inflamed subtype of lung adenocarcinoma brain metastases that correlates with prolonged survival.
    Clin Cancer Res. 2020 Jan 17. pii: 1078-0432.CCR-19-2184.
    PubMed     Abstract available

  33. WEN PY, Cloughesy TF, Olivero AG, Morrissey KM, et al
    First-in-human Phase I study to evaluate the brain-penetrant PI3K/mTOR inhibitor GDC-0084 in patients with progressive or recurrent high-grade glioma.
    Clin Cancer Res. 2020 Jan 14. pii: 1078-0432.CCR-19-2808.
    PubMed     Abstract available

  34. RODRIGUEZ GUTIERREZ D, Jones C, Varlet P, Mackay A, et al
    Radiological evaluation of newly diagnosed non-brainstem pediatric high-grade glioma in the HERBY phase II trial.
    Clin Cancer Res. 2020 Jan 10. pii: 1078-0432.CCR-19-3154.
    PubMed     Abstract available

  35. TU Y, Chen Z, Zhao P, Sun G, et al
    Smoothened promotes glioblastoma radiation resistance via activating USP3-mediated Claspin deubiquitination.
    Clin Cancer Res. 2020 Jan 3. pii: 1078-0432.CCR-19-1515.
    PubMed     Abstract available

  36. HIGUCHI F, Nagashima H, Ning J, Koerner MVA, et al
    Restoration of Temozolomide Sensitivity by Poly(ADP-Ribose) Polymerase inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair.
    Clin Cancer Res. 2020 Jan 3. pii: 1078-0432.CCR-19-2000.
    PubMed     Abstract available

    December 2019
  37. WORONIECKA KI, Rhodin KE, Dechant CA, Waibl Polania J, et al
    4-1BB Agonism Averts TIL Exhaustion and Licenses PD-1 Blockade in Glioblastoma and Other Intracranial Cancers.
    Clin Cancer Res. 2019 Dec 23. pii: 1078-0432.CCR-19-1068.
    PubMed     Abstract available

  38. WU S, Gao F, Zheng S, Zhang C, et al
    EGFR amplification induces increased DNA damage response and renders selective sensitivity to Talazoparib (PARP inhibitor) in glioblastoma.
    Clin Cancer Res. 2019 Dec 18. pii: 1078-0432.CCR-19-2549.
    PubMed     Abstract available

  39. VAUBEL RA, Tian S, Remonde D, Schroeder MA, et al
    Genomic and phenotypic characterization of a broad panel of patient derived xenografts reflects the diversity of glioblastoma.
    Clin Cancer Res. 2019 Dec 18. pii: 1078-0432.CCR-19-0909.
    PubMed     Abstract available

  40. ZHANG DY, Dmello C, Chen L, Arrieta VA, et al
    Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations.
    Clin Cancer Res. 2019 Dec 12. pii: 1078-0432.CCR-19-2182.
    PubMed     Abstract available

  41. HARGRAVE DR, Bouffet E, Tabori U, Broniscer A, et al
    Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study.
    Clin Cancer Res. 2019 Dec 6. pii: 1078-0432.CCR-19-2177.
    PubMed     Abstract available

  42. CAMPAGNE O, Zhong B, Nair S, Lin T, et al
    Exposure-Toxicity Association of Cyclophosphamide and Its Metabolites in Infants and Young Children with Primary Brain Tumors: Implications for Dosing.
    Clin Cancer Res. 2019 Dec 3. pii: 1078-0432.CCR-19-2685.
    PubMed     Abstract available

    October 2019
  43. BAGLEY S, Nabavizadeh SA, Mays J, Till JE, et al
    Clinical utility of plasma cell-free DNA in adult patients with newly diagnosed glioblastoma - a pilot prospective study.
    Clin Cancer Res. 2019 Oct 30. pii: 1078-0432.CCR-19-2533.
    PubMed     Abstract available

  44. PARADA CA, Osbun JW, Busald T, Karasozen Y, et al
    Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals Rb1 signaling as a Novel Mediator and Biomarker.
    Clin Cancer Res. 2019 Oct 15. pii: 1078-0432.CCR-18-0641.
    PubMed     Abstract available

    September 2019
  45. GERSTNER E, Emblem KE, Chang K, Vakulenko-Lagun B, et al
    Bevacizumab reduces permeability and concurrent temozolomide delivery in a subset of patients with recurrent glioblastoma.
    Clin Cancer Res. 2019 Sep 26. pii: 1078-0432.CCR-19-1739.
    PubMed     Abstract available

  46. VAN DER VOORT SR, Incekara F, Wijnenga MM, Kapsas G, et al
    Predicting the 1p/19q co-deletion status of presumed low grade glioma with an externally validated machine learning algorithm.
    Clin Cancer Res. 2019 Sep 23. pii: 1078-0432.CCR-19-1127.
    PubMed     Abstract available

  47. SHARIFI Z, Abdulkarim B, Meehan B, Rak J, et al
    Antitumor Activity of a Binary EGFR/DNA Targeting Strategy Overcomes Resistance of Glioblastoma Stem cells to Temozolomide.
    Clin Cancer Res. 2019 Sep 20. pii: 1078-0432.CCR-19-0955.
    PubMed     Abstract available

  48. THOMAS RP, Nagpal S, Iv M, Soltys SG, et al
    Macrophage Exclusion after Radiation Therapy (MERT): A First in Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma.
    Clin Cancer Res. 2019 Sep 19. pii: 1078-0432.CCR-19-1421.
    PubMed     Abstract available

  49. PAPACHRISTODOULOU A, Silginer M, Weller M, Schneider H, et al
    Therapeutic targeting of TGF-beta ligands in glioblastoma using novel antisense oligonucleotides reduces the growth of experimental gliomas.
    Clin Cancer Res. 2019 Sep 17. pii: 1078-0432.CCR-17-3024.
    PubMed     Abstract available

  50. JUTHANI R, Madajewski B, Yoo B, Zhang L, et al
    Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model.
    Clin Cancer Res. 2019 Sep 12. pii: 1078-0432.CCR-19-1834.
    PubMed     Abstract available

  51. CHAUVIN C, Joalland N, Perroteau J, Jarry U, et al
    NKG2D controls natural reactivity of Vgamma9Vdelta2 T lymphocytes against mesenchymal glioblastoma cells.
    Clin Cancer Res. 2019 Sep 10. pii: 1078-0432.CCR-19-0375.
    PubMed     Abstract available

  52. JI J, Xu R, Ding K, Bao G, et al
    Long noncoding RNA SChLAP1 forms a growth promoting complex with HNRNPL in human glioblastoma through stabilization of ACTN4 and activation of NF-kappaB signaling.
    Clin Cancer Res. 2019 Sep 6. pii: 1078-0432.CCR-19-0747.
    PubMed     Abstract available

  53. WERBROUCK C, Evangelista CCS, Lobon-Iglesias MJ, Barret E, et al
    TP53 pathway alterations drive radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG).
    Clin Cancer Res. 2019 Sep 3. pii: 1078-0432.CCR-19-0126.
    PubMed     Abstract available

  54. LI J, Xue Y, Wenger A, Sun Y, et al
    Individual Assignment of Adult Diffuse Gliomas into the EM/PM Molecular Subtypes Using a TaqMan Low-Density Array.
    Clin Cancer Res. 2019 Sep 3. pii: 1078-0432.CCR-19-0299.
    PubMed     Abstract available

    August 2019
  55. BODEKER KL, Allen BG, Smith MC, Monga V, et al
    First-in-human phase 1 clinical trial of pharmacological ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma.
    Clin Cancer Res. 2019 Aug 19. pii: 1078-0432.CCR-19-0594.
    PubMed     Abstract available

    July 2019
  56. WEN PY, Reardon DA, Armstrong TS, Phuphanich S, et al
    A Randomized Double-Blind Placebo-Controlled Phase 2 Trial Of Dendritic Cell Vaccine ICT-107 In Newly Diagnosed Patients With Glioblastoma.
    Clin Cancer Res. 2019 Jul 18. pii: 1078-0432.CCR-19-0261.
    PubMed     Abstract available

  57. JUAREZ-CHAMBI RM, Kut C, Rico-Jimenez JJ, Chaichana KL, et al
    AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography.
    Clin Cancer Res. 2019 Jul 17. pii: 1078-0432.CCR-19-0854.
    PubMed     Abstract available

  58. YANG ZJ, Du F, Yuelling LW, Lee EH, et al
    Leukotriene synthesis is critical for medulloblastoma progression.
    Clin Cancer Res. 2019 Jul 12. pii: 1078-0432.CCR-18-3549.
    PubMed     Abstract available

  59. TIEN AC, Li J, Bao X, DeRogatis A, et al
    A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort.
    Clin Cancer Res. 2019 Jul 8. pii: 1078-0432.CCR-19-0133.
    PubMed     Abstract available

  60. JONSSON P, Lin AL, Young RJ, DiStefano NM, et al
    Genomic correlates of disease progression and treatment response in prospectively characterized gliomas.
    Clin Cancer Res. 2019 Jul 1. pii: 1078-0432.CCR-19-0032.
    PubMed     Abstract available

    June 2019
  61. RAPP C, Dettling S, Liu F, Ull AT, et al
    Cytotoxic T-cells and their activation status are independent prognostic markers in meningiomas.
    Clin Cancer Res. 2019 Jun 21. pii: 1078-0432.CCR-19-0389.
    PubMed     Abstract available

  62. KATAGI H, Louis N, Unruh D, Sasaki T, et al
    Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma.
    Clin Cancer Res. 2019 Jun 21. pii: 1078-0432.CCR-18-3890.
    PubMed     Abstract available

  63. FECCI PE, Champion CD, Hoj J, McKernan C, et al
    The Evolving Modern Management of Brain Metastasis.
    Clin Cancer Res. 2019 Jun 18. pii: 1078-0432.CCR-18-1624.
    PubMed     Abstract available

    May 2019
  64. SMITH SJ, Tyler B, Gould TWA, Veal GJ, et al
    Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste.
    Clin Cancer Res. 2019 May 21. pii: 1078-0432.CCR-18-3850.
    PubMed     Abstract available

    March 2019
  65. IDBAIH A, Canney M, Belin L, Desseaux C, et al
    Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma.
    Clin Cancer Res. 2019 Mar 19. pii: 1078-0432.CCR-18-3643.
    PubMed     Abstract available

  66. LI H, Li J, Chen L, Qi S, et al
    HERC3-mediated SMAD7 ubiquitination degradation promotes autophagy-induced EMT and chemoresistance in glioblastoma.
    Clin Cancer Res. 2019 Mar 12. pii: 1078-0432.CCR-18-3791.
    PubMed     Abstract available

  67. LAMANO JB, Lamano JB, Li YD, DiDomenico JD, et al
    Glioblastoma-Derived IL-6 Induces Immunosuppressive Peripheral Myeloid Cell PD-L1 and Promotes Tumor Growth.
    Clin Cancer Res. 2019 Mar 1. pii: 1078-0432.CCR-18-2402.
    PubMed     Abstract available

    February 2019
  68. TOMASZEWSKI W, Sanchez-Perez L, Gajewski TF, Sampson JH, et al
    Brain Tumor Micro-environment and Host State - Implications for Immunotherapy.
    Clin Cancer Res. 2019 Feb 25. pii: 1078-0432.CCR-18-1627.
    PubMed     Abstract available

  69. LASSMAN AB, Roberts-Rapp LA, Sokolova I, Song M, et al
    Comparison of Biomarker Assays for EGFR: Implications for Precision Medicine in Patients with Glioblastoma.
    Clin Cancer Res. 2019 Feb 22. pii: 1078-0432.CCR-18-3034.
    PubMed     Abstract available

  70. HALL PE, Lewis R, Syed N, Shaffer R, et al
    A Phase I study of pegylated arginine deiminase (pegargiminase), cisplatin and pemetrexed in argininosuccinate synthetase 1-deficient recurrent high-grade glioma.
    Clin Cancer Res. 2019 Feb 22. pii: 1078-0432.CCR-18-3729.
    PubMed     Abstract available

  71. IPPEN FM, Alvarez-Breckenridge CA, Kuter BM, Fink AL, et al
    The dual PI3K/mTOR-pathway inhibitor GDC-0084 achieves antitumor activity in PIK3CA-mutant breast cancer brain metastases.
    Clin Cancer Res. 2019 Feb 22. pii: 1078-0432.CCR-18-3049.
    PubMed     Abstract available

  72. SIM HW, Nejad R, Zhang W, Nassiri F, et al
    Tissue 2-hydroxyglutarate as a biomarker for isocitrate dehydrogenase (IDH) mutations in gliomas.
    Clin Cancer Res. 2019 Feb 18. pii: 1078-0432.CCR-18-3205.
    PubMed     Abstract available

    January 2019
  73. INDIRA CHANDRAN V, Welinder C, Mansson AS, Offer S, et al
    Ultrasensitive immunoprofiling of plasma extracellular vesicles identifies syndecan-1 as a potential tool for minimally invasive diagnosis of glioma.
    Clin Cancer Res. 2019 Jan 24. pii: 1078-0432.CCR-18-2946.
    PubMed     Abstract available

  74. FINK MA, Paland H, Herzog S, Grube M, et al
    L-Carnitine Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme.
    Clin Cancer Res. 2019 Jan 22. pii: 1078-0432.CCR-18-2380.
    PubMed     Abstract available

  75. YUN J, Hong MH, Kim SY, Park CW, et al
    YH25448, an irreversible EGFR-TKI with Potent Intracranial Activity in EGFR mutant non-small-cell lung cancer.
    Clin Cancer Res. 2019 Jan 22. pii: 1078-0432.CCR-18-2906.
    PubMed     Abstract available

  76. PARK J, Kwon M, Kim KH, Kim TS, et al
    Immune Checkpoint Inhibitor-Induced Reinvigoration of Tumor-Infiltrating CD8(+) T Cells is Determined by Their Differentiation Status in Glioblastoma.
    Clin Cancer Res. 2019 Jan 18. pii: 1078-0432.CCR-18-2564.
    PubMed     Abstract available

  77. MAJZNER RG, Theruvath JL, Nellan A, Heitzeneder S, et al
    CAR T cells targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors.
    Clin Cancer Res. 2019 Jan 17. pii: 1078-0432.CCR-18-0432.
    PubMed     Abstract available

  78. BERGEN ES, Berghoff AS, Medjedovic M, Rudas M, et al
    Continued endocrine therapy is associated with improved survival in patients with breast cancer brain metastases.
    Clin Cancer Res. 2019 Jan 15. pii: 1078-0432.CCR-18-1968.
    PubMed     Abstract available

  79. CHENG VWT, Soto MS, Khrapitchev AA, Perez-Balderas F, et al
    VCAM-1-targeted MRI Enables Detection of Brain Micrometastases from Different Primary Tumors.
    Clin Cancer Res. 2019;25:533-543.
    PubMed     Abstract available

  80. IORGULESCU JB, Torre M, Harary M, Smith TR, et al
    The Misclassification of Diffuse Gliomas: Rates and Outcomes.
    Clin Cancer Res. 2019 Jan 11. pii: 1078-0432.CCR-18-3101.
    PubMed     Abstract available

    December 2018
  81. HURVITZ SA, O'Shaughnessy J, Mason G, Yardley D, et al
    Central Nervous System Metastasis in Patients With HER2-Positive Metastatic Breast Cancer: Patient Characteristics, Treatment, and Survival From SystHERs.
    Clin Cancer Res. 2018 Dec 28. pii: 1078-0432.CCR-18-2366.
    PubMed     Abstract available

  82. INDRACCOLO S, Lombardi G, Fassan M, Pasqualini L, et al
    Genetic, epigenetic and immunologic profiling of MMR-deficient relapsed glioblastoma.
    Clin Cancer Res. 2018 Dec 4. pii: 1078-0432.CCR-18-1892.
    PubMed     Abstract available

  83. HEGI ME, Genbrugge E, Gorlia T, Stupp R, et al
    MGMT Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide. A Pooled Analysis of Four Clinical Trials.
    Clin Cancer Res. 2018 Dec 4. pii: 1078-0432.CCR-18-3181.
    PubMed     Abstract available

    November 2018
  84. DAVIDSON TB, Lee AH, Hsu M, Sedighim S, et al
    Expression of PD-1 by T cells in malignant glioma patients reflects exhaustion and activation.
    Clin Cancer Res. 2018 Nov 29. pii: 1078-0432.CCR-18-1176.
    PubMed     Abstract available

  85. THULBORN KR, Lu A, Atkinson IC, Pauliah M, et al
    Residual Tumor Volume, Cell Volume Fraction and Tumor Cell Kill During Fractionated Chemoradiation Therapy of Human Glioblastoma using Quantitative Sodium MR imaging.
    Clin Cancer Res. 2018 Nov 28. pii: 1078-0432.CCR-18-2079.
    PubMed     Abstract available

  86. ROBBINS DJ, Rodriguez-Blanco J, Li B, Shen C, et al
    A CK1alpha activator penetrates the brain, and shows efficacy against drug-resistant metastatic medulloblastoma.
    Clin Cancer Res. 2018 Nov 28. pii: 1078-0432.CCR-18-1319.
    PubMed     Abstract available

  87. CHOI BD, Maus MV, June CH, Sampson JH, et al
    ----Immunotherapy for Glioblastoma: Adoptive T-cell Strategies.
    Clin Cancer Res. 2018 Nov 16. pii: 1078-0432.CCR-18-1625.
    PubMed     Abstract available

  88. SPINO M, Kurz SC, Chiriboga L, Serrano J, et al
    Cell surface Notch ligand DLL3 is a therapeutic target in isocitrate dehydrogenase mutant glioma.
    Clin Cancer Res. 2018 Nov 5. pii: 1078-0432.CCR-18-2312.
    PubMed     Abstract available

    October 2018
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    Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy.
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    Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy.
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  91. AGNIHOTRI S, Mansouri S, Burrell K, Li M, et al
    Ketoconazole and Posaconazole Selectively Target HK2 Expressing Glioblastoma Cells.
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    Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients.
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    Arming an oncolytic herpes simplex virus Type 1 with a single chain fragment variable antibody against PD-1 for experimental glioblastoma therapy.
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    September 2018
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    No sugar added: A new strategy to inhibit glioblastoma receptor tyrosine kinases.
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    Metabolic Reprogramming by Dual AKT/ERK Inhibition Through Imipridones Elicits Unique Vulnerabilities in Glioblastoma.
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    The oncometabolite D-2-hydroxyglutarate is an intercellular mediator in IDH-mutant gliomas that inhibits both complement and T cells.
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    Dual MAPK inhibition is an effective therapeutic strategy for a subset of class II BRAF mutant melanoma.
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    Immunotherapy of Primary Brain Tumors: Facts and Hopes.
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    Targeted Therapies for Brain Tumors: Will They Ever Deliver?
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    Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and elicits Synthetic Lethality in Glioblastoma.
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    Toxicity and efficacy of a novel GADD34-expressing oncolytic HSV-1 for the treatment of experimental glioblastoma.
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