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Cervical Cancer

Free Subscription 22.07.2024 1 Acta Obstet Gynecol Scand 1 Am J Cancer Res 1 Anticancer Drugs 1 Biochim Biophys Acta Mol Basis Dis 1 Bioelectrochemistry 1 Biotechnol J 3 BMC Cancer 1 BMC Palliat Care 3 BMC Womens Health 1 Brachytherapy 1 Cancer Pathog Ther 1 Cancer Rep (Hoboken) 2 Cancers (Basel) 1 Clin Transl Oncol 1 Cureus 1 Curr Gene Ther 1 Curr Opin Oncol 1 Diagnostics (Basel) 2 Ecancermedicalscience 1 EClinicalMedicine 2 Eur J Obstet Gynecol Reprod Biol 1 Eur J Oncol Nurs 1 Exp Ther Med 2 Front Immunol 3 Front Oncol 1 Front Pharmacol 1 Gynecol Oncol 1 Gynecol Oncol Rep 1 Heliyon 1 Hum Cell 1 Indian J Cancer 1 Infect Disord Drug Targets 1 Int J Cancer 1 Int J Mol Sci 1 iScience 1 J Appl Clin Med Phys 1 J Assist Reprod Genet 1 J Biophotonics 2 J Clin Med 1 J Gynecol Oncol 1 J Immunother Cancer 2 J Obstet Gynaecol Can 1 J Obstet Gynaecol Res 1 J Proteome Res 1 J Transl Med 1 Mol Divers 1 NPJ Precis Oncol 1 PLoS Comput Biol 1 PLoS Med 1 PLoS One 1 Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 1 Quant Imaging Med Surg 1 Radiol Med 1 Radiother Oncol 2 Taiwan J Obstet Gynecol 1 Tumour Biol 2 Vaccine

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Single Articles

Acta Obstet Gynecol Scand

1. LINDQUIST S, Kjaer SK, Frederiksen K, Ornskov D, et al
   Clinical performance of human papillomavirus based cervical cancer screening algorithm: The result of a large Danish implementation study.
   Acta Obstet Gynecol Scand. 2024 Jul 16. doi: 10.1111/aogs.14915.
   PubMed         Abstract available
   
   

   
   Am J Cancer Res

2. HAN GH, Kim HR, Yun H, Chung JY, et al
   Developing a comprehensive molecular subgrouping model for cervical cancer using machine learning.
   Am J Cancer Res. 2024;14:3186-3197.
   PubMed         Abstract available
   
   

   
   Anticancer Drugs

3. ZHU Z, Nie X, Deng L, Ding J, et al
   Regulation of cervical cancer via G15-mediated inhibition of G protein-coupled estrogen receptor.
   Anticancer Drugs. 2024 Jul 17. doi: 10.1097/CAD.0000000000001640.
   PubMed         Abstract available
   
   

   
   Biochim Biophys Acta Mol Basis Dis

4. HE C, Zhang J, Bai X, Lu C, et al
   Lysine lactylation-based insight to understanding the characterization of cervical cancer.
   Biochim Biophys Acta Mol Basis Dis. 2024 Jul 16:167356.
   PubMed         Abstract available
   
   

   
   Bioelectrochemistry

5. KUNTAMUNG K, Sangthong P, Jakmunee J, Ounnunkad K, et al
   Simultaneous immunodetection of multiple cervical cancer biomarkers based on a signal-amplifying redox probes/polyethyleneimine-coated gold nanoparticles/2D tungsten disulfide/graphene oxide nanocomposite platform.
   Bioelectrochemistry. 2024;160:108780.
   PubMed         Abstract available
   
   

   
   Biotechnol J

6. CHI C, Tang X, Liu W, Zhou Y, et al
   Exosomal lncRNA USP30-AS1 activates the Wnt/beta-catenin signaling pathway to promote cervical cancer progression via stabilization of beta-catenin by USP30.
   Biotechnol J. 2024;19:e2300653.
   PubMed         Abstract available
   
   

   
   BMC Cancer

7. CONG H, Yang X, Li Z, Li Z, et al
   Salvage radiotherapy for locally recurrent cervical and endometrial carcinoma: clinical outcomes and toxicities.
   BMC Cancer. 2024;24:871.
   PubMed         Abstract available
   
   
8. DE LA CRUZ-LOPEZ KG, Alvarado-Ortiz E, Valencia-Gonzalez HA, Beltran-Anaya FO, et al
   Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines.
   BMC Cancer. 2024;24:853.
   PubMed         Abstract available
   
   
9. YOU J, Yuan Y, Gu X, Wang W, et al
   Pegylated recombinant human granulocyte colony-stimulating factor for primary prophylaxis of neutropenia in patients with cervical cancer receiving concurrent chemoradiotherapy: a prospective study.
   BMC Cancer. 2024;24:833.
   PubMed         Abstract available
   
   

   
   BMC Palliat Care

10. OWARE J, Iddrisu M, Konlan KD, Dzansi G, et al
    Challenges and support systems of nurses caring for women with advanced cervical cancer in Accra, Ghana.
    BMC Palliat Care. 2024;23:174.
    PubMed         Abstract available
    
    

    
    BMC Womens Health

11. DENECKE A, Emar D, Hillemanns P, Ramachandran D, et al
    Diagnostic cervical excision in patients with HPV positivity, cytological abnormalities- and preoperative cervical stenosis.
    BMC Womens Health. 2024;24:411.
    PubMed         Abstract available
    
    
12. NAKAMURA K, Kigure K, Nishimura T, Yamashita S, et al
    Questionnaire survey on cervical cancer screening and HPV awareness among patients at a local cancer center in Japan.
    BMC Womens Health. 2024;24:402.
    PubMed         Abstract available
    
    
13. EZZELARAB S, El-Husseiny A, Nasreldin M, Ali R, et al
    Cervical cancer screening by cytology and the burden of epithelial abnormalities in low resource settings: a tertiary-center 42-year study.
    BMC Womens Health. 2024;24:405.
    PubMed         Abstract available
    
    

    
    Brachytherapy

14. PORTOCARRERO-BONIFAZ A, Syed S, Kassel M, McKenzie GW, et al
    Dosimetric and toxicity comparison between Syed-Neblett and Fletcher-Suit-Delclos Tandem and Ovoid applicators in high dose rate cervix cancer brachytherapy.
    Brachytherapy. 2024;23:397-406.
    PubMed         Abstract available
    
    

    
    Cancer Pathog Ther

15. JI C, Liu S, Wang C, Chen J, et al
    Relationship between visceral obesity and prognosis in patients with stage IVB cervical cancer receiving radiotherapy and chemotherapy.
    Cancer Pathog Ther. 2023;2:180-186.
    PubMed         Abstract available
    
    

    
    Cancer Rep (Hoboken)

16. NARTEY Y, Amo-Antwi K, Hill PC, Dassah ET, et al
    Risk Factors for Cervical Cancer in Ghana.
    Cancer Rep (Hoboken). 2024;7:e2124.
    PubMed         Abstract available
    
    

    
    Cancers (Basel)

17. MURAMOTO Y, Murakami N, Okonogi N, Takatsu J, et al
    Dose Contribution to the Regional Lymph-Node Metastases and Point B from Intracavity and Interstitial Hybrid Brachytherapy in Locally Advanced Cervical Cancer.
    Cancers (Basel). 2024;16:2384.
    PubMed         Abstract available
    
    
18. FLORES CEA, Falang BM, Gomez-Laguna L, Gutierrez GG, et al
    Enhancing Cervical Cancer Screening with 7-Type HPV mRNA E6/E7 Testing on Self-Collected Samples: Multicentric Insights from Mexico.
    Cancers (Basel). 2024;16:2485.
    PubMed         Abstract available
    
    

    
    Clin Transl Oncol

19. PEREZ-CRUZ E, Howlet-Caballero LC, Villanueva XJ
    Association of albumin, neutrophil-lymphocyte ratio and lymphocytes with clinical stage in cervical cancer patients.
    Clin Transl Oncol. 2024 Jul 13. doi: 10.1007/s12094-024-03575.
    PubMed         Abstract available
    
    

    
    Cureus

20. NNADI EN, Khatun N, John S
    A Rare Encounter With Unusual Metastasis: Metastatic Right Ventricular Tumor Secondary to Cervical Cancer.
    Cureus. 2024;16:e62530.
    PubMed         Abstract available
    
    

    
    Curr Gene Ther

21. DING X, Wan A, Qi X, Jiang K, et al
    ZNF695, A Potential Prognostic Biomarker, Correlates with Im mune Infiltrates in Cervical Squamous Cell Carcinoma and Endoce rvical Adenocarcinoma: Bioinformatic Analysis and Experimental Verification.
    Curr Gene Ther. 2024;24:441-452.
    PubMed         Abstract available
    
    

    
    Curr Opin Oncol

22. ALONSO-ESPIAS M, Gracia M, Zapardiel I
    Benefits of sentinel node detection in cervical cancer.
    Curr Opin Oncol. 2024 Jun 13. doi: 10.1097/CCO.0000000000001063.
    PubMed         Abstract available
    
    

    
    Diagnostics (Basel)

23. LUCIC S, Spirovski M, Stojanovic D, Peter A, et al
    18F-FDG PET/CT- and MRI-Based Locally Advanced Cervical Cancer Early-Response Assessment after Concurrent Chemo- and Radiotherapy-Impact on Patient Outcomes and Survival Prediction.
    Diagnostics (Basel). 2024;14:1432.
    PubMed         Abstract available
    
    

    
    Ecancermedicalscience

24. ONYANGO OE, Masinde D, Ouma C
    Improving cervical cancer screening rates among women of reproductive age in rural Kisumu County through dialogue-based community health education.
    Ecancermedicalscience. 2024;18:1713.
    PubMed         Abstract available
    
    
25. RASHEED FA, Yakasai IA, Abdurrahman A, Usman A, et al
    Human papillomavirus serotypes and determinants among women with invasive cervical cancer in Katsina state, Northwest-Nigeria: a multicentre study.
    Ecancermedicalscience. 2024;18:1714.
    PubMed         Abstract available
    
    

    
    EClinicalMedicine

26. FALCONER H, Norberg-Hardie A, Salehi S, Alfonzo E, et al
    Oncologic outcomes after Total Mesometrial Resection (TMMR) or treatment according to current international guidelines in FIGO (2009) stages IB1-IIB cervical cancer: an observational cohort study.
    EClinicalMedicine. 2024;73:102696.
    PubMed         Abstract available
    
    

    
    Eur J Obstet Gynecol Reprod Biol

27. ABU-ZAID A, Baradwan S, Alyafi M, Al Baalharith M, et al
    Association between polycystic ovary syndrome and the risk of malignant gynecologic cancers (ovarian, endometrial, and cervical): A population-based study from the U.S.A. National Inpatient Sample 2016-2019.
    Eur J Obstet Gynecol Reprod Biol. 2024;299:283-288.
    PubMed         Abstract available
    
    
28. WANG ZY, Li R, Li RZ, Pei KG, et al
    Prognostic value of human papillomavirus cell-free DNA in cervical cancer patients: A systematic review and meta-analysis.
    Eur J Obstet Gynecol Reprod Biol. 2024;300:211-218.
    PubMed         Abstract available
    
    

    
    Eur J Oncol Nurs

29. HU J, Liu G, Liu Y, Yuan M, et al
    Predicting lower limb lymphedema after cervical cancer surgery using artificial neural network and decision tree models.
    Eur J Oncol Nurs. 2024;72:102650.
    PubMed         Abstract available
    
    

    
    Exp Ther Med

30. WANG W, Yao S, Jiang H, Dong J, et al
    [Retracted] Upstream transcription factor 1 prompts malignancies of cervical cancer primarily by transcriptionally activating p65 expression.
    Exp Ther Med. 2024;28:342.
    PubMed         Abstract available
    
    

    
    Front Immunol

31. SCHINDLER S, Netto E, Deminco F, Figueiredo CA, et al
    Detection of cytokines in cervicovaginal lavage in HIV-infected women and its association with high-risk human papillomavirus.
    Front Immunol. 2024;15:1416204.
    PubMed         Abstract available
    
    
32. LI J, Zhang X, Yang L, Zhu Y, et al
    Corrigendum: Targeted proteomics-determined multi-biomarker profiles developed classifier for prognosis and immunotherapy responses of advanced cervical cancer.
    Front Immunol. 2024;15:1437676.
    PubMed         Abstract available
    
    

    
    Front Oncol

33. WU L, Li S, Li S, Lin Y, et al
    Preoperative magnetic resonance imaging-radiomics in cervical cancer: a systematic review and meta-analysis.
    Front Oncol. 2024;14:1416378.
    PubMed         Abstract available
    
    
34. MWENDA V, Murage D, Kilonzo C, Bor JP, et al
    Baseline assessment of cervical cancer screening and treatment capacity in 25 counties in Kenya, 2022.
    Front Oncol. 2024;14:1371529.
    PubMed         Abstract available
    
    
35. ARANGO-BRAVO EA, Galicia-Carmona T, Cetina-Perez L, Flores-de la Torre CB, et al
    State of the art of cervical cancer treatment in rare histologies.
    Front Oncol. 2024;14:1386294.
    PubMed         Abstract available
    
    

    
    Front Pharmacol

36. LAGU IJL, Nyamai DW, Njeru SN
    Phytochemical analysis, in-vitro and in-silico study of antiproliferative activity of ethyl acetate fraction of Launaea cornuta (Hochst. ex Oliv. & Hiern) C. Jeffrey against human cervical cancer cell line.
    Front Pharmacol. 2024;15:1399885.
    PubMed         Abstract available
    
    

    
    Gynecol Oncol

37. BERGSTEIN A, Huang Y, Hershman DL, Xu X, et al
    Impact of medicaid expansion on cervical cancer screening: A state-specific difference in difference analysis.
    Gynecol Oncol. 2024;189:49-55.
    PubMed         Abstract available
    
    

    
    Gynecol Oncol Rep

38. LIM L, Slee A, Lim PC
    Feasibility and early oncologic outcomes of Total Intracorporeal Robotic Radical Hysterectomy with Vaginal Cerclage (TIRRHVC) for the treatment of clinical stage IB cervical cancer: A tumor containment technique.
    Gynecol Oncol Rep. 2024;54:101437.
    PubMed         Abstract available
    
    

    
    Heliyon

39. LI S, Gao K, Yao D
    Comprehensive Analysis of angiogenesis associated genes and tumor microenvironment infiltration characterization in cervical cancer.
    Heliyon. 2024;10:e33277.
    PubMed         Abstract available
    
    

    
    Hum Cell

40. HU X, Wang W, Ma T, Zhang W, et al
    Long non-coding RNA SIX1-1 promotes proliferation of cervical cancer cells via negative transcriptional regulation of RASD1.
    Hum Cell. 2024 Jul 16. doi: 10.1007/s13577-024-01104.
    PubMed         Abstract available
    
    

    
    Indian J Cancer

41. BASHAR MA, Khan IA
    Introduction of HPV vaccine in universal immunization programme of India: A step in the right direction for the elimination of cervical cancer.
    Indian J Cancer. 2024 Jul 13. doi: 10.4103.
    PubMed        
    
    

    
    Infect Disord Drug Targets

42. KUMAR N, Mangla M, Palo S, Gabbeta S, et al
    Stratified Mucin-Producing Intraepithelial Lesion of the Cervix in an HPV-16 Positive Woman: A Rare Encounter.
    Infect Disord Drug Targets. 2024;24:e290124226396.
    PubMed         Abstract available
    
    

    
    Int J Cancer

43. LYNGE E, Bennekou Schroll J, Andersen B, Balasubramaniam K, et al
    Cervical cancer incidence in Denmark: Disentangling determinants of time trend.
    Int J Cancer. 2024 Jul 14. doi: 10.1002/ijc.35081.
    PubMed         Abstract available
    
    

    
    Int J Mol Sci

44. VALLE-MENDIOLA A, Rocha-Zavaleta L, Maldonado-Lagunas V, Morelos-Laguna D, et al
    STAT5 Is Necessary for the Metabolic Switch Induced by IL-2 in Cervical Cancer Cell Line SiHa.
    Int J Mol Sci. 2024;25:6835.
    PubMed         Abstract available
    
    

    
    iScience

45. GU Y, Mu Q, Cheng D
    Androgens in cervical cancer: Their role in epidemiology and biology.
    iScience. 2024;27:110155.
    PubMed         Abstract available
    
    

    
    J Appl Clin Med Phys

46. JINDAKAN S, Tharavichitkul E, Watcharawipha A, Nobnop W, et al
    Improvement of treatment plan quality with modified fixed field volumetric modulated arc therapy in cervical cancer.
    J Appl Clin Med Phys. 2024 Jul 20:e14479. doi: 10.1002/acm2.14479.
    PubMed         Abstract available
    
    

    
    J Assist Reprod Genet

47. COURBIERE B, Miquel L, Bottin P, Provansal M, et al
    Heterotopic ovarian transplantation instead hormonal replacement therapy after radical hysterectomy for cervical cancer: case report and review of literature.
    J Assist Reprod Genet. 2024 Jul 14. doi: 10.1007/s10815-024-03196.
    PubMed         Abstract available
    
    

    
    J Biophotonics

48. KARTHIKA J, Anantharaju A, Koodi D, Pandya HJ, et al
    Label-free assessment of the transformation zone using multispectral diffuse optical imaging toward early detection of cervical cancer.
    J Biophotonics. 2024 Jul 20:e202400114. doi: 10.1002/jbio.202400114.
    PubMed         Abstract available
    
    

    
    J Clin Med

49. TANAKA T, Nishie R, Murakami H, Tsuchihashi H, et al
    Oncologic Outcomes of Patients with Early-Stage Cervical Cancer after Minimally Invasive Radical Hysterectomy and Sentinel Lymph Node Biopsy.
    J Clin Med. 2024;13:3981.
    PubMed         Abstract available
    
    
50. VAN TRAPPEN P, Walgraeve MS, Roels S, Claes N, et al
    Robotic-Assisted Pelvic Exenteration for Cervical Cancer: A Systematic Review and Novel Insights into Compartment-Based Imaging.
    J Clin Med. 2024;13:3673.
    PubMed         Abstract available
    
    

    
    J Gynecol Oncol

51. KAMATA M, Fusegi A, Kurihara N, Abe A, et al
    Effects of tumor spillage prevention in laparoscopic radical hysterectomy for early-stage cervical cancer: a propensity score-matched analysis.
    J Gynecol Oncol. 2024 Jul 12. doi: 10.3802/jgo.2025.
    PubMed         Abstract available
    
    

    
    J Immunother Cancer

52. THAREJA G, Salvioni A, Lauzeral-Vizcaino F, Halabi N, et al
    Assessing the implications of sentinel lymph node removal in cervical cancer: an immunogenetic perspective - a SENTICOL ancillary study.
    J Immunother Cancer. 2024;12:e008734.
    PubMed         Abstract available
    
    

    
    J Obstet Gynaecol Can

53. CHIKAZAWA K, Imai K, Kuwata T, Konno R, et al
    What Is the Future of Radical Hysterectomy? Commentary on the Indication for Minimally Invasive Surgery for Cervical Cancer
    J Obstet Gynaecol Can. 2024;46:102242.
    PubMed        
    
    
54. KHAOULA M, Saber Hassine A, Sirine B, Sana M, et al
    Cervix Relapses of Lymphoblastic Leukemia Type B.
    J Obstet Gynaecol Can. 2024;46:102414.
    PubMed        
    
    

    
    J Obstet Gynaecol Res

55. NOOR MOHAMAD NA, Omar J
    Cervical cancer in Malaysia.
    J Obstet Gynaecol Res. 2024 Jul 19. doi: 10.1111/jog.16031.
    PubMed         Abstract available
    
    

    
    J Proteome Res

56. PENG Q, Deng Y, Li G, Li J, et al
    Quantitative Proteomics Reveal the Mechanism of MiR-138-5p Suppressing Cervical Cancer via Targeting ZNF385A.
    J Proteome Res. 2024 Jul 18. doi: 10.1021/acs.jproteome.4c00349.
    PubMed         Abstract available
    
    

    
    J Transl Med

57. WEI LJ, Fu J, Yang HX, Yang X, et al
    Evaluation of pathological response to neoadjuvant chemotherapy in locally advanced cervical cancer.
    J Transl Med. 2024;22:655.
    PubMed         Abstract available
    
    

    
    Mol Divers

58. KOUR S, Biswas I, Sheoran S, Arora S, et al
    Betulin: a novel triterpenoid anti-cancerous agent targeting cervical cancer through epigenetic proteins.
    Mol Divers. 2024 Jul 16. doi: 10.1007/s11030-024-10930.
    PubMed         Abstract available
    
    

    
    NPJ Precis Oncol

59. WANG F, Yue S, Huang Q, Lei T, et al
    Cellular heterogeneity and key subsets of tissue-resident memory T cells in cervical cancer.
    NPJ Precis Oncol. 2024;8:145.
    PubMed         Abstract available
    
    

    
    PLoS Comput Biol

60. STUART RM, Cohen JA, Kerr CC, Mathur P, et al
    HPVsim: An agent-based model of HPV transmission and cervical disease.
    PLoS Comput Biol. 2024;20:e1012181.
    PubMed         Abstract available
    
    

    
    PLoS Med

61. HERWEIJER E, Hu K, Wang J, Lu D, et al
    Incidence of oncogenic HPV infection in women with and without mental illness: A population-based cohort study in Sweden.
    PLoS Med. 2024;21:e1004372.
    PubMed         Abstract available
    
    

    
    PLoS One

62. CASTELLANO T, ElHabr AK, Washington C, Ting J, et al
    Health disparities in cervical cancer: Estimating geographic variations of disease burden and association with key socioeconomic and demographic factors in the US.
    PLoS One. 2024;19:e0307282.
    PubMed         Abstract available
    
    

    
    Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med

63. IBRAIMOVA DD, Tilekov EA, Shaimbetov BO, Bekeshova EN, et al
    [The lost years of potential life under cancer of neck of uterus in the Kyrgyz Republic].
    Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med. 2024;32:462-466.
    PubMed         Abstract available
    
    

    
    Quant Imaging Med Surg

64. WANG X, Feng C, Huang M, Liu S, et al
    Cervical cancer segmentation based on medical images: a literature review.
    Quant Imaging Med Surg. 2024;14:5176-5204.
    PubMed         Abstract available
    
    

    
    Radiol Med

65. NINKOVA RV, Calabrese A, Curti F, Riccardi S, et al
    The performance of the node reporting and data system 1.0 (Node-RADS) and DWI-MRI in staging patients with cervical carcinoma according to the new FIGO classification (2018).
    Radiol Med. 2024;129:1062-1075.
    PubMed         Abstract available
    
    

    
    Radiother Oncol

66. NI R, Han K, Haibe-Kains B, Rink A, et al
    Generalizability of deep learning in organ-at-risk segmentation: A transfer learning study in cervical brachytherapy.
    Radiother Oncol. 2024;197:110332.
    PubMed         Abstract available
    
    

    
    Taiwan J Obstet Gynecol

67. SINGH P, Gothwal M, Yadav G
    Dual-staining with P16 and Ki67 in the triaging of ASC-US and the LSIL group beneficial or added financial burden, still a diagnostic dilemma.
    Taiwan J Obstet Gynecol. 2024;63:593.
    PubMed        
    
    
68. SRISUTTAYASATHIEN M, Kantathavorn N, Luasiripanthu T, Petchjorm S, et al
    Response to "Is it practical to add the p16/Ki67 immunohistochemical dual staining into liquid-based cytology for cervical cancer screening?".
    Taiwan J Obstet Gynecol. 2024;63:592.
    PubMed        
    
    

    
    Tumour Biol

69. TISHE ZH, Shawkat S, Popy MN, Mumu SB, et al
    Cervical cancer risk in association with TNF-alpha gene polymorphisms in Bangladeshi women.
    Tumour Biol. 2024;46:13-24.
    PubMed         Abstract available
    
    

    
    Vaccine

70. CERNUSCHI T, Hall S, Malvolti S, Bloem P, et al
    Improving access to human papillomavirus vaccines: A case study in the IA2030 core principle of partnership.
    Vaccine. 2022 Dec 7:S0264-410X(22)01453-0. doi: 10.1016/j.vaccine.2022.
    PubMed         Abstract available
    
    
71. DULL PM, Achilles SL, Ahmed R, Barnabas RV, et al
    Meeting report: Considerations for trial design and endpoints in licensing therapeutic HPV16/18 vaccines to prevent cervical cancer.
    Vaccine. 2024 Jul 13:S0264-410X(24)00741-2. doi: 10.1016/j.vaccine.2024.
    PubMed         Abstract available
    
    

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