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Diabetes

Free Subscription 22.12.2025 2 Am J Med 1 Biochem Biophys Res Commun 7 Diabetes 13 Diabetes Care 12 Diabetes Obes Metab 9 Diabetologia 1 Invest Ophthalmol Vis Sci 1 J Am Coll Cardiol 9 J Clin Endocrinol Metab 1 J Clin Invest 1 J Diabetes Complications 2 Metabolism 1 N Engl J Med 2 Nature 1 Pediatr Diabetes 9 PLoS One

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Single Articles

Am J Med

1. CHEN JJ, Tsai MH, Ho WY, Fang YW, et al
   Cardio-renal Outcomes in Type 2 Diabetes Patients with Advanced Chronic Kidney Disease on SGLT2 inhibitors or GLP-1 receptor agonists.
   Am J Med. 2025 Dec 17:S0002-9343(25)00839-3. doi: 10.1016/j.amjmed.2025.
   PubMed         Abstract available
   
   
2. HASHIMOTO Y, Fujikawa T
   Severe CA19-9 Elevation in Diabetes: A Pancreatic Cancer Pitfall.
   Am J Med. 2025 Dec 13:S0002-9343(25)00847-2. doi: 10.1016/j.amjmed.2025.
   PubMed        
   
   

   
   Biochem Biophys Res Commun

3. HUHEMUREN, Haoriwa, Qi Y, Li X, et al
   Multi-organ protective effects of ursodeoxycholic acid in a rat model of type 2 diabetes mellitus.
   Biochem Biophys Res Commun. 2025;796:153150.
   PubMed         Abstract available
   
   

   
   Diabetes

4. ROSSING P
   Dickkopf 3 in Urine: A Help for Prioritizing Management of Kidney Disease in Type 2 Diabetes.
   Diabetes. 2026;75:17-18.
   PubMed        
   
   
5. PAGE B
   Diabetes Spotlight: Susan Bailey Gurley, MD, PhD-Charting Hypertension and Diabetic Nephropathy Through Mouse Models.
   Diabetes. 2026;75:1-2.
   PubMed        
   
   
6. UDDIN MI, Dieckmann B, Burgos DE
   Imaging Hypoxia in the Diabetic Retina: A Potential Early-Detection Imaging Biomarker Before Detectable Retinopathy in Diabetes.
   Diabetes. 2025 Dec 19:db250394. doi: 10.2337/db25-0394.
   PubMed         Abstract available
   
   
7. ZHOU L, Hong Y, Li X, Zhang Y, et al
   Mitochondrial mGPDH Modulates Fibroblast Function in Diabetic Wound Healing via the SIRT1-c-Myc-TGF-beta1 Axis.
   Diabetes. 2025 Dec 16:db250539. doi: 10.2337/db25-0539.
   PubMed         Abstract available
   
   
8. OSHIMA M, Halliez C, Kobaisi F, Mode N, et al
   Killing of Human beta-Cells by CD8+ T Cells Triggers Inflammatory Paracrine Signaling and Neighboring beta-Cell Dysfunction.
   Diabetes. 2026;75:124-132.
   PubMed         Abstract available
   
   
9. SALAZAR S, Delgadillo-Silva LF, Carapeto P, Kenfaoui MM, et al
   Additive Effects of Dorzagliatin and Glucagon-Like Peptide 1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice.
   Diabetes. 2026;75:99-114.
   PubMed         Abstract available
   
   
10. GONCALVES LM, Shirvaikar I, Sideris K, Pereira E, et al
    Microvascular Homeostasis Is Compromised in Pancreatic Islets in a Mouse Model of beta-Cell Loss and Low-Grade Inflammation.
    Diabetes. 2026;75:70-84.
    PubMed         Abstract available
    
    

    
    Diabetes Care

11. MOEDT E, Coca SG, Edwards K, Neuen BL, et al
    Baseline Risk and Longitudinal Changes in kidneyintelX.dkd and Its Association With Kidney Outcomes in the CANVAS and CREDENCE Trials.
    Diabetes Care. 2026;49:92-98.
    PubMed         Abstract available
    
    
12. LE D, Kilpatrick M, Kraft WK, Grams ME, et al
    GLP-1s Versus DPP-4s and Risk of Dementia in Patients Requiring Hemodialysis: A Target Trial Emulation Study.
    Diabetes Care. 2026;49:128-136.
    PubMed         Abstract available
    
    
13. LEHMANN V, Hilpert M, Mostaani Z, Hovsepyan S, et al
    Listening to Hypoglycemia: Voice as a Biomarker for Detection of a Medical Emergency Using Machine Learning.
    Diabetes Care. 2026;49:105-110.
    PubMed         Abstract available
    
    
14. TONG J, Li N, Hu F, Yue Y, et al
    Metabolic Improvement Mediates the Causal Relationship Between GLP-1 Receptor Agonists and Myocardial Infarction: A Mendelian Randomization and Mediation Analysis Study.
    Diabetes Care. 2026;49:171-178.
    PubMed         Abstract available
    
    
15. BERKOWITZ SA
    What's Keeping the U.S. From Better Population Health?
    Diabetes Care. 2026;49:22-29.
    PubMed         Abstract available
    
    
16. WANG B, Wang N, Yin X, Huang Y, et al
    Gestational Diabetes Mellitus and Accelerated Biological Aging in Middle-Aged and Elderly Women.
    Diabetes Care. 2025 Dec 16:dc251842. doi: 10.2337/dc25-1842.
    PubMed         Abstract available
    
    
17. MOSCOSO-VASQUEZ M, Ekhlaspour L, Brown SA, DeBoer MD, et al
    Safety and Feasibility of a Fully Automated Insulin Delivery System: FCL@Home, a Multicenter Randomized Clinical Trial in Individuals With Type 1 Diabetes.
    Diabetes Care. 2025 Dec 16:dc251526. doi: 10.2337/dc25-1526.
    PubMed         Abstract available
    
    
18. WEISS A, Chakievska L, Achenbach P, Hergl M, et al
    Stratifying the Rate of Disease Progression by Progression Likelihood Scores in Children and Adolescents With Stage 1 and Stage 2 Type 1 Diabetes in Germany.
    Diabetes Care. 2025 Dec 16:dc252184. doi: 10.2337/dc25-2184.
    PubMed         Abstract available
    
    
19. QI MM, Wang MM
    Comment on Tanabe et al. Prediction of Sarcopenia Onset in Type 2 Diabetes Using Urinary Titin Levels: A Japanese Prospective Cohort Study. Diabetes Care 2025;48:1844-1849.
    Diabetes Care. 2026;49:e4-e5.
    PubMed        
    
    
20. PAGE B
    About the Editor: Jonathan Shaw, MD, MRCP (U.K.), FRACP, FAAHMS-The Epidemiology of Early-Onset Type 2 Diabetes.
    Diabetes Care. 2026;49:2.
    PubMed        
    
    
21. BELFORT-DEAGUIAR R, Yeckel CW, Elshafie A, Comarella AP, et al
    Association of Insulin Resistance and Insulin Secretion Indices and Glucose Metrics From Continuous Glucose Monitoring in People With Obesity.
    Diabetes Care. 2026;49:152-160.
    PubMed         Abstract available
    
    
22. SHIMABUKURO M, Tanabe H, Nomura K, Matsuo M, et al
    Response to Comment on Tanabe et al. Prediction of Sarcopenia Onset in Type 2 Diabetes Using Urinary Titin Levels: A Japanese Prospective Cohort Study. Diabetes Care 2025;48:1844-1849.
    Diabetes Care. 2026;49:e6-e7.
    PubMed        
    
    
23. KAHN SE, Anderson CAM, Buse JB, Selvin E, et al
    Three Years on at Diabetes Care: Achievements, New Initiatives, and Fresh Challenges.
    Diabetes Care. 2026;49:3-4.
    PubMed        
    
    

    
    Diabetes Obes Metab

24. CHUNG GE, Yu SJ, Park J, Kim YJ, et al
    Associations between steatotic liver disease subtypes and incident diabetes in young Korean adults: A nationwide cohort study.
    Diabetes Obes Metab. 2025 Dec 15. doi: 10.1111/dom.70381.
    PubMed         Abstract available
    
    
25. DEFRONZO RA
    Chronically elevated sympathetic nervous system tone: A significant, common, and poorly realised contributor to cardiometabolic disease in type 2 diabetes.
    Diabetes Obes Metab. 2025 Dec 15. doi: 10.1111/dom.70347.
    PubMed        
    
    
26. LUI JNM, Wong KTC, Lau ESH, Chan SCS, et al
    Work productivity, associated risk factors and costs on presenteeism and absenteeism in Chinese patients with young-onset type-2 diabetes in Hong Kong.
    Diabetes Obes Metab. 2025 Dec 16. doi: 10.1111/dom.70352.
    PubMed         Abstract available
    
    
27. ZHANG S, Zhang J, Yang Y, Zhu W, et al
    Global prevalence of chronic kidney disease in type 1 diabetes: A systematic review and meta-analysis.
    Diabetes Obes Metab. 2025 Dec 17. doi: 10.1111/dom.70378.
    PubMed         Abstract available
    
    
28. SANFILIPPO S, Thurm U, Renfordt M, Schierbauer J, et al
    Performance of three simultaneously used rtCGM systems around a physically active weekend camp in adults with type 1 diabetes: A prospective lab and real-world study.
    Diabetes Obes Metab. 2025 Dec 19. doi: 10.1111/dom.70369.
    PubMed         Abstract available
    
    
29. MALTONI G, Bernardini L, Scozzarella A, Candela E, et al
    High co-incidence of coeliac disease in paediatric type 1 diabetes: A call for systematic screening.
    Diabetes Obes Metab. 2025 Dec 19. doi: 10.1111/dom.70395.
    PubMed        
    
    
30. MINSKY NC, Olshanskiy D, Aharon-Hananel G
    Effect of semaglutide add-on therapy for people living with type 1 diabetes and excess weight.
    Diabetes Obes Metab. 2025 Dec 19. doi: 10.1111/dom.70389.
    PubMed        
    
    
31. SPEZANI R, Mandarim-de-Lacerda CA
    Beyond diabetes and obesity: GLP-1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation.
    Diabetes Obes Metab. 2025 Dec 19. doi: 10.1111/dom.70400.
    PubMed         Abstract available
    
    
32. YANG B, Sun F, Poon ET, Wang J, et al
    Effects of exercise interventions on 24-h continuous glucose profiles in non-diabetic populations: A systematic review and meta-analysis.
    Diabetes Obes Metab. 2025 Dec 19. doi: 10.1111/dom.70368.
    PubMed         Abstract available
    
    
33. LEE SH, Han KA, Hong EG, Kang JG, et al
    Efficacy and safety of combining empagliflozin in people with type 2 diabetes mellitus uncontrolled with metformin and sitagliptin: A randomised, double-blind, multicentre, therapeutic confirmatory phase 3 clinical trial.
    Diabetes Obes Metab. 2025 Dec 19. doi: 10.1111/dom.70386.
    PubMed         Abstract available
    
    
34. HE Y, Dai Z, Yu AP, Wong SH, et al
    Efficacy of a low-carbohydrate diet combined with exercise on glycemic control and metabolic health in type 2 diabetes mellitus: A systematic review and meta-analysis.
    Diabetes Obes Metab. 2025 Dec 19. doi: 10.1111/dom.70379.
    PubMed         Abstract available
    
    
35. TOURKMANI AM, Al-Harbi TJ, Alghamdi AA, Youzghadli IM, et al
    Literature-informed ensemble machine learning for three-year diabetic kidney disease risk prediction in type 2 diabetes: Development, validation, and deployment of the PSMMC NephraRisk model.
    Diabetes Obes Metab. 2025 Dec 15. doi: 10.1111/dom.70385.
    PubMed         Abstract available
    
    

    
    Diabetologia

36. KOBAYATI A, Tsoukas MA, Garfield N, Legault L, et al
    Inter- and intra-physician variability in insulin injection adjustments compared with Bayesian algorithm recommendations in type 1 diabetes.
    Diabetologia. 2025 Dec 15. doi: 10.1007/s00125-025-06627.
    PubMed         Abstract available
    
    
37. JI L, Nai Y, Chen Z, Zhong Y, et al
    alpha7 Nicotinic acetylcholine receptor activation rescues mitochondrial dysfunction in gestational diabetes mellitus by competing with p66Shc for VDAC1 binding.
    Diabetologia. 2025 Dec 15. doi: 10.1007/s00125-025-06640.
    PubMed         Abstract available
    
    
38. CHOI W
    Impact of normoglycaemia and prediabetes definitions on the estimated benefits of regression from prediabetes to normoglycaemia for type 2 diabetes risk.
    Diabetologia. 2025 Dec 15. doi: 10.1007/s00125-025-06636.
    PubMed        
    
    
39. ZHOU X, Sevilla-Gonzalez M, Phipps AI, Udler M, et al
    Diabetogenic processes for insulin resistance-linked hyperinsulinaemia are associated with colorectal cancer.
    Diabetologia. 2025 Dec 15. doi: 10.1007/s00125-025-06631.
    PubMed         Abstract available
    
    
40. CHIRIACO M, Trico D, Petrie JR, Gabriel R, et al
    Impact of overweight and obesity on fasting insulin secretion in men and women without diabetes: effect sizes and mechanisms.
    Diabetologia. 2025 Dec 18. doi: 10.1007/s00125-025-06643.
    PubMed         Abstract available
    
    
41. MATTILA M, Haario P, Hakola L, Takkinen HM, et al
    Dietary intake of vitamins A, B, C, D and E and risk of islet autoimmunity and type 1 diabetes in genetically at-risk children: a prospective study from the DIPP birth cohort.
    Diabetologia. 2025 Dec 19. doi: 10.1007/s00125-025-06635.
    PubMed         Abstract available
    
    
42. ANJOM-SHOAE J, Fitzgerald PCE, Rose BD, Bitarafan V, et al
    Effects of combined intraduodenal administration of lauric acid and L-tryptophan on postprandial plasma glucose, glucoregulatory hormones and gastric emptying in type 2 diabetes: a double-blind, randomised, crossover study.
    Diabetologia. 2025 Dec 19. doi: 10.1007/s00125-025-06630.
    PubMed         Abstract available
    
    
43. QIN X, Chen S, Sun Y, Ma Z, et al
    Aberrant STING signalling promotes endothelial dysfunction and neurovascular injury in diabetic retinopathy.
    Diabetologia. 2025 Dec 19. doi: 10.1007/s00125-025-06628.
    PubMed         Abstract available
    
    
44. NEVES JS, Leite AR, Vale C, Marques P, et al
    Efficacy of tirzepatide versus semaglutide in achieving therapeutic targets in type 2 diabetes: a post hoc analysis of the SURPASS-2 Trial.
    Diabetologia. 2025 Dec 19. doi: 10.1007/s00125-025-06637.
    PubMed         Abstract available
    
    

    
    Invest Ophthalmol Vis Sci

45. YOKOTA H, Hayashi H, Nakagami H, Kushiyama A, et al
    Evidence Supporting Autotaxin as a Potential New Drug Treatment Target in Patients With Advanced Diabetic Retinopathy.
    Invest Ophthalmol Vis Sci. 2025;66:49.
    PubMed         Abstract available
    
    

    
    J Am Coll Cardiol

46. DAS SR, Bonaca MP, Creager MA, Maruthur N, et al
    Management of Peripheral Artery Disease in Adults With Diabetes: 2025 ACC Scientific Statement: A Report of the American College of Cardiology.
    J Am Coll Cardiol. 2025 Dec 17:S0735-1097(25)10282.
    PubMed         Abstract available
    
    

    
    J Clin Endocrinol Metab

47. RAHMAN MH, Arian A, Konda S, McGuinn LA, et al
    Predicting Incident Type 2 Diabetes Using Wearable Activity and Polygenic Risk: A Survival-Modeling Study in All of Us.
    J Clin Endocrinol Metab. 2025 Dec 15:dgaf673. doi: 10.1210.
    PubMed         Abstract available
    
    
48. CHEN J, Wu Y, Li F, Guo Q, et al
    Causal effect of type 1 diabetes on juvenile idiopathic arthritis and the mediating role of CD8+ natural killer T cells.
    J Clin Endocrinol Metab. 2025 Dec 15:dgaf664. doi: 10.1210.
    PubMed         Abstract available
    
    
49. LIU L, Mohan S, Wu L
    GLP-1 Receptor Agonists and Non-Arteritic Anterior Ischemic Optic Neuropathy: What an Endocrinologist Needs to Know.
    J Clin Endocrinol Metab. 2025;111:e308-e313.
    PubMed         Abstract available
    
    
50. RAETS L, Van Hoorenbeeck K, Maes T, Lee D, et al
    Women With Higher GCT Levels but NGT Have a Similarly High Risk for Glucose Intolerance Postpartum as Women With GDM.
    J Clin Endocrinol Metab. 2025;111:e281-e291.
    PubMed         Abstract available
    
    
51. DI GIUSEPPE G, Gliozzo G, Ciccarelli G, Carciero L, et al
    Altered GIP/GLP-1 Secretion Ratio is Associated With Impaired beta Cell Function in Humans.
    J Clin Endocrinol Metab. 2025;111:e240-e246.
    PubMed         Abstract available
    
    
52. BROGAN RJ, Rooyackers O, Phillips BE, Twelkmeyer B, et al
    Biomarkers of Insulin Resistance and Their Performance as Predictors of Treatment Response in Overweight Adults.
    J Clin Endocrinol Metab. 2025;111:244-255.
    PubMed         Abstract available
    
    
53. LI S, Liu J, Yang C, Jin Y, et al
    Impaired Glucagon Suppression Accompanied by Liver Fat Accumulation Mediated Worse Blood Glucose Control in Patients With T2D.
    J Clin Endocrinol Metab. 2025;111:180-198.
    PubMed         Abstract available
    
    
54. SWARTZ AZ, Wood K, Farber-Eger E, Petty A, et al
    Weight Trajectory Impacts Risk for 10 Distinct Cardiometabolic Diseases.
    J Clin Endocrinol Metab. 2025;111:e49-e57.
    PubMed         Abstract available
    
    
55. MAYA J, Schulte CCM, Hsu S, James K, et al
    Gestational Glucose Intolerance and Risk of Obesity in Childhood and Adolescence.
    J Clin Endocrinol Metab. 2025 Jun 13:dgaf345. doi: 10.1210.
    PubMed         Abstract available
    
    

    
    J Clin Invest

56. CHEN HC, Bang MF, Wang HH, Shpargel KB, et al
    UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes.
    J Clin Invest. 2025 Dec 16:e196325. doi: 10.1172/JCI196325.
    PubMed         Abstract available
    
    

    
    J Diabetes Complications

57. CHENG L, Cheng S, Zhu R, Xu G, et al
    Ezetimibe attenuates diabetic retinopathy via NRF2-mediated suppression of inflammation and oxidative stress.
    J Diabetes Complications. 2025;40:109250.
    PubMed         Abstract available
    
    

    
    Metabolism

58. ZHANG J, Guan X, Kong M, Xia M, et al
    GLP-1RAs and tirzepatide may reduce heart failure risk in obese but not in non-obese patients with cardiovascular or renal disease: A systematic review and meta-analysis.
    Metabolism. 2026;175:156433.
    PubMed         Abstract available
    
    
59. D'ADDIO F, Bucciarelli L, Lunati ME, Fiorina P, et al
    Metabolic and immune dysfunction at the crossroads between type 1 diabetes and neurodegeneration.
    Metabolism. 2025 Dec 17:156471. doi: 10.1016/j.metabol.2025.156471.
    PubMed         Abstract available
    
    

    
    N Engl J Med

60. NICHOLLS SJ, Pavo I, Bhatt DL, Buse JB, et al
    Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes.
    N Engl J Med. 2025;393:2409-2420.
    PubMed         Abstract available
    
    

    
    Nature

61. ZHU D, Zhao J, Cai H, Chu X, et al
    Mazdutide versus placebo in Chinese adults with type 2 diabetes.
    Nature. 2025 Dec 17. doi: 10.1038/s41586-025-10026.
    PubMed         Abstract available
    
    
62. GUO L, Zhang B, Xue X, Zhang X, et al
    Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes.
    Nature. 2025 Dec 17. doi: 10.1038/s41586-025-10031.
    PubMed         Abstract available
    
    

    
    Pediatr Diabetes

63. WONG R, Wiggen T, Hall MA, Johnson SG, et al
    The Effect of COVID-19 on Incident Diabetes in Pediatric Patients: Findings From the National COVID-19 Cohort Collaborative (N3C).
    Pediatr Diabetes. 2025;2025:3545727.
    PubMed         Abstract available
    
    

    
    PLoS One

64. JISAN JE, Rahman M, Zahan MS, Sarkar P, et al
    Assessing readiness of health facilities for hypertension and integration with diabetes care in Bangladesh: Evidence from the National Service Provision Assessment Survey.
    PLoS One. 2025;20:e0339405.
    PubMed         Abstract available
    
    
65. VAUTHIER JC, Choley L, Kabuth B
    Chronic illness and extreme performance: Type 1 diabetes in ultra-endurance.
    PLoS One. 2025;20:e0338637.
    PubMed         Abstract available
    
    
66. MANI T, Sappani M, Joy M, Garg C, et al
    Spatial patterning of hypertension and its association with comorbidities and risk factors: A cross-sectional study in South India.
    PLoS One. 2025;20:e0336252.
    PubMed         Abstract available
    
    
67. 
    Retraction: Improvement of non-invasive tests of liver steatosis and fibrosis as indicators for non-alcoholic fatty liver disease in type 2 diabetes mellitus patients with elevated cardiovascular risk profile using the PPAR-alpha/gamma agonist aleglit
    PLoS One. 2025;20:e0339230.
    PubMed        
    
    
68. 
    Retraction: Investigating the relationship between insulin use and all-cause mortality, breast cancer mortality, and recurrence risk in diabetic patients with breast cancer: A comprehensive systematic review and meta-analysis.
    PLoS One. 2025;20:e0339149.
    PubMed        
    
    
69. 
    Retraction: Correlations between parameters of glycaemic variability and foetal growth, neonatal hypoglycaemia and hyperbilirubinemia in women with gestational diabetes.
    PLoS One. 2025;20:e0338857.
    PubMed        
    
    
70. 
    Retraction: Cardiovascular and mortality outcomes of DPP-4 inhibitors vs. sulfonylureas as metformin add-on therapy in patients with type 2 diabetes: A systematic review and meta-analysis.
    PLoS One. 2025;20:e0339098.
    PubMed        
    
    
71. 
    Retraction: Investigating the association between diabetes and carpal tunnel syndrome: A systematic review and meta-analysis approach.
    PLoS One. 2025;20:e0338989.
    PubMed        
    
    
72. DANSO EK, Asare P, Tetteh AY, Tetteh P, et al
    Mycobacterium tuberculosis complex lineages and drug resistance patterns among tuberculosis patients with or without diabetes mellitus in southern Ghana.
    PLoS One. 2025;20:e0338498.
    PubMed         Abstract available
    
    

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