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CC Journal Club

Our weekly journal club for junior residents and medical students


  Drug Resistance

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03.03.2025

1 AIDS
2 Antimicrob Agents Chemother
1 BMJ
1 Clin Infect Dis
5 Int J Antimicrob Agents
1 J Antimicrob Chemother
1 J Med Microbiol
3 J Virol
1 JAMA
4 PLoS One
1 Virology


  Retrieve available abstracts of this week’s articles:
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Single Articles


    AIDS

  1. MUCCINI C, Spagnuolo V, Zazzi M, Castagna A, et al
    People with four-class drug-resistant HIV-1 may have low levels of intact DNA.
    AIDS. 2025;39:475-476.
    PubMed         Abstract available


    Antimicrob Agents Chemother

  2. YU H, Wang L, Liu X, Zheng J, et al
    Mechanistic insights into the multitarget synergistic efficacy of farrerol and beta-lactam antibiotics in combating methicillin-resistant Staphylococcus aureus.
    Antimicrob Agents Chemother. 2025 Feb 28:e0155124. doi: 10.1128/aac.01551.
    PubMed         Abstract available

  3. FU S-Y, Chen X-Z, Yi P-C, Gao J, et al
    Optimizing phage therapy for carbapenem-resistant Enterobacter cloacae bacteremia: insights into dose and timing.
    Antimicrob Agents Chemother. 2025 Feb 26:e0168324. doi: 10.1128/aac.01683.
    PubMed         Abstract available


    BMJ

  4. WILKINSON E
    Efforts to tackle antimicrobial resistance are having "limited impact," NAO warns.
    BMJ. 2025;388:r418.
    PubMed        


    Clin Infect Dis

  5. STEFANOVIC A, Alam ME, Matic N, Larnder A, et al
    Increased Severity of Multidrug-Resistant Shigella sonnei Infections in People Experiencing Homelessness.
    Clin Infect Dis. 2025;80:339-346.
    PubMed         Abstract available


    Int J Antimicrob Agents

  6. CHEN M, Jiang S, Sun L, Wang H, et al
    "Seesaw effect" between daptomycin and ceftobiprole in daptomycin-resistant methicillin-resistant staphylococcus aureus isolates.
    Int J Antimicrob Agents. 2025 Feb 20:107469.
    PubMed         Abstract available

  7. CHEN X, Sun Z, Chen J, Xu X, et al
    The hidden threat: Klebsiella pneumoniae may develop co-resistance to colistin and cefiderocol under pressure of colistin.
    Int J Antimicrob Agents. 2025;65:107445.
    PubMed         Abstract available

  8. TAVARES RDS, Tacao M, Henriques I
    Integrons are key players in the spread of beta-lactamase-encoding genes.
    Int J Antimicrob Agents. 2025;65:107421.
    PubMed         Abstract available

  9. ZHOU P, Gao H, Li M, Wu C, et al
    Characterization of a novel KPC-2 variant, KPC-228, conferring resistance to ceftazidime-avibactam in an ST11-KL64 hypervirulent Klebsiella pneumoniae.
    Int J Antimicrob Agents. 2025;65:107411.
    PubMed         Abstract available

  10. SODAGARI HR, Sohail MN, Varga C
    Temporal, regional, and demographic differences among antimicrobial-resistant domestic Campylobacter jejuni human infections across the United States, 2013-2019.
    Int J Antimicrob Agents. 2025 Feb 20:107467.
    PubMed         Abstract available


    J Antimicrob Chemother

  11. SERAPIDE F, Serraino R, Spadafora L, Bernardi M, et al
    Clinical characteristics, therapy and outcome of bloodstream infections caused by vancomycin-resistant enterococci: a multicentre clinical experience.
    J Antimicrob Chemother. 2025 Feb 25:dkaf055. doi: 10.1093.
    PubMed         Abstract available


    J Med Microbiol

  12. EBRAHIM H, Haldenby S, Moore MP, Dashti AA, et al
    Genotypic and phenotypic analyses of two distinct sets of Pseudomonas aeruginosa urinary tract isolates.
    J Med Microbiol. 2025;74.
    PubMed         Abstract available


    J Virol

  13. FEDORCHENKO SV, Klimenko Z, Martynovich T, Solianyk I, et al
    Retreatment of patients with chronic hepatitis C, subtype 3a, and cirrhosis, who previously failed a regimen containing second-generation NS5A inhibitors with sofosbuvir + glecaprevir/pibrentasvir and ribavirin for 16-24 weeks.
    J Virol. 2025 Jan 22:e0184324. doi: 10.1128/jvi.01843.
    PubMed         Abstract available

  14. COHEN P, Lambson BE, Mkhize NN, Moodley C, et al
    Resistance mutations that distinguish HIV-1 envelopes with discordant VRC01 phenotypes from multi-lineage infections in the HVTN703/HPTN081 trial: implications for cross-resistance.
    J Virol. 2025 Jan 16:e0173024. doi: 10.1128/jvi.01730.
    PubMed         Abstract available

  15. ARORA P, Zhang L, Nehlmeier I, Kempf A, et al
    Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D.
    J Virol. 2025 Jan 10:e0123024. doi: 10.1128/jvi.01230.
    PubMed         Abstract available


    JAMA

  16. SCHWEITZER K
    Five Engineering Advancements That May Help Solve the Growing Threat of Antimicrobial Resistance.
    JAMA. 2025 Feb 28. doi: 10.1001/jama.2024.28174.
    PubMed        


    PLoS One

  17. ABABNEH Q, Aldaken N, Jaradat Z, Al-Rousan E, et al
    Predominance of extensively-drug resistant Acinetobacter baumannii carrying bla OXA-23 in Jordanian patients admitted to the intensive care units.
    PLoS One. 2025;20:e0317798.
    PubMed         Abstract available

  18. ARDILA CM, Gonzalez-Arroyave D, Tobon S
    Machine learning for predicting antimicrobial resistance in critical and high-priority pathogens: A systematic review considering antimicrobial susceptibility tests in real-world healthcare settings.
    PLoS One. 2025;20:e0319460.
    PubMed         Abstract available

  19. MEDRANO H, Hill S, Boulianne M, Cereno T, et al
    Widespread dissemination of Salmonella, Escherichia coli and Campylobacter resistant to medically important antimicrobials in the poultry production continuum in Canada.
    PLoS One. 2025;20:e0319086.
    PubMed         Abstract available

  20. AREFIN MS, Mitu MJ, Mitu SY, Nurjahan A, et al
    Mutational alterations in the QRDR regions associated with fluoroquinolone resistance in Pseudomonas aeruginosa of clinical origin from Savar, Dhaka.
    PLoS One. 2025;20:e0302352.
    PubMed         Abstract available


    Virology

  21. LIN P, Liu S, Cao Z, Zeng Y, et al
    An experimental study on the lytic bacteriophage MSP15 with wide-spectrum targeting methicillin-resistant Staphylococcus aureus.
    Virology. 2025;605:110452.
    PubMed         Abstract available


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