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Articles published in Clin Cancer Res

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    January 2019
  1. MULLEN MM, Mutch DG
    Endometrial tumor immune response: predictive biomarker of response to immunotherapy.
    Clin Cancer Res. 2019 Jan 28. pii: 1078-0432.CCR-18-4122.
    PubMed     Text format     Abstract available


  2. GREENWOOD HE, McCormick PN, Gendron T, Glaser M, et al
    Measurement of tumor antioxidant capacity and prediction of chemotherapy resistance in preclinical models of ovarian cancer by positron emission tomography.
    Clin Cancer Res. 2019 Jan 16. pii: 1078-0432.CCR-18-3423.
    PubMed     Text format     Abstract available


  3. BINZER-PANCHAL A, Hardell E, Viklund B, Ghaderi M, et al
    Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes.
    Clin Cancer Res. 2019 Jan 7. pii: 1078-0432.CCR-18-2792.
    PubMed     Text format     Abstract available


    December 2018
  4. BLAGDEN SP, Hamilton AL, Mileshkin L, Wong S, et al
    Phase IB Dose-Escalation and Expansion Study of AKT kinase inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-Resistant Ovarian Cancer.
    Clin Cancer Res. 2018 Dec 18. pii: 1078-0432.CCR-18-2277.
    PubMed     Text format     Abstract available


  5. KITSON S, Maskell Z, Sivalingam VN, Allen JL, et al
    PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a multi-center, randomized double-blind, placebo-controlled phase 3 trial.
    Clin Cancer Res. 2018 Dec 18. pii: 1078-0432.CCR-18-3339.
    PubMed     Text format     Abstract available


  6. TALHOUK A, Derocher H, Schmidt P, Leung S, et al
    Molecular subtype not immune response drives outcomes in endometrial carcinoma.
    Clin Cancer Res. 2018 Dec 6. pii: 1078-0432.CCR-18-3241.
    PubMed     Text format     Abstract available


    November 2018
  7. HOLST F, Werner HMJ, Mjos S, Hoivik EA, et al
    PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma.
    Clin Cancer Res. 2018 Nov 15. pii: 1078-0432.CCR-18-0452.
    PubMed     Text format     Abstract available


  8. DE JONGE MM, Auguste A, van Wijk LM, Schouten PC, et al
    Frequent homologous recombination deficiency in high-grade endometrial carcinomas.
    Clin Cancer Res. 2018 Nov 9. pii: 1078-0432.CCR-18-1443.
    PubMed     Text format     Abstract available


    October 2018
  9. WU G, Cao L, Zhu J, Tan Z, et al
    Loss of RBMS3 Confers Platinum-resistance in Epithelial Ovarian Cancer via Activation of miR-126-5p/beta-catenin/CBP signaling.
    Clin Cancer Res. 2018 Oct 2. pii: 1078-0432.CCR-18-2554.
    PubMed     Text format     Abstract available


    September 2018
  10. MATUSZEWSKA K, Santry LA, Van Vloten JP, Au Yeung A, et al
    Combining Vascular Normalization with an Oncolytic Virus Enhances Immunotherapy in Advanced Stage Ovarian Cancer.
    Clin Cancer Res. 2018 Sep 11. pii: 1078-0432.CCR-18-0220.
    PubMed     Text format     Abstract available


    August 2018
  11. LHEUREUX S, Tinker AV, Clarke BA, Ghatage P, et al
    A clinical and molecular Phase II trial of oral ENMD-2076 in ovarian clear cell carcinoma (OCCC): A study of the Princess Margaret Phase II Consortium.
    Clin Cancer Res. 2018 Aug 14. pii: 1078-0432.CCR-18-1244.
    PubMed     Text format     Abstract available


  12. PISANIC TR, Cope L, Lin SF, Yen TT, et al
    Methylomic analysis of ovarian cancers identifies tumor-specific alterations readily detectable in early precursor lesions.
    Clin Cancer Res. 2018 Aug 14. pii: 1078-0432.CCR-18-1199.
    PubMed     Text format     Abstract available


  13. SOUMERAI TE, Donoghue MTA, Bandlamudi C, Srinivasan P, et al
    CLINICAL UTILITY OF PROSPECTIVE MOLECULAR CHARACTERIZATION IN ADVANCED ENDOMETRIAL CANCER.
    Clin Cancer Res. 2018 Aug 1. pii: 1078-0432.CCR-18-0412.
    PubMed     Text format     Abstract available


    July 2018
  14. TOKER A, Nguyen LT, Stone SC, Yang C, et al
    Regulatory T cells in ovarian cancer are characterized by a highly activated phenotype distinct from that in melanoma.
    Clin Cancer Res. 2018 Jul 31. pii: 1078-0432.CCR-18-0554.
    PubMed     Text format     Abstract available


  15. MCNEISH IA
    Neoantigens in ovarian cancer: embarrassment of riches or needles in a haystack?
    Clin Cancer Res. 2018 Jul 6. pii: 1078-0432.CCR-18-1731.
    PubMed     Text format     Abstract available


  16. CHEN GM, Kannan L, Geistlinger L, Kofia V, et al
    Consensus on Molecular Subtypes of High-grade Serous Ovarian Carcinoma.
    Clin Cancer Res. 2018 Jul 3. pii: 1078-0432.CCR-18-0784.
    PubMed     Text format     Abstract available


  17. BLYUSS O, Burnell M, Ryan A, Gentry-Maharaj A, et al
    Comparison of longitudinal CA125 algorithms as a first line screen for ovarian cancer in the general population.
    Clin Cancer Res. 2018 Jul 3. pii: 1078-0432.CCR-18-0208.
    PubMed     Text format     Abstract available


  18. YANG H, Mao W, Rodriguez-Aguayo C, Mangala LS, et al
    Paclitaxel Sensitivity of Ovarian Cancer can be enhanced by knocking down Pairs of Kinases that regulate MAP4 Phosphorylation and Microtubule Stability.
    Clin Cancer Res. 2018 Jul 3. pii: 1078-0432.CCR-18-0504.
    PubMed     Text format     Abstract available


    June 2018
  19. SIMPKINS F, Jang K, Yoon H, Hew K, et al
    Dual Src and MEK inhibition decreases ovarian cancer growth and targets tumor initiating stem-like cells.
    Clin Cancer Res. 2018 Jun 29. pii: 1078-0432.CCR-17-3697.
    PubMed     Text format     Abstract available


  20. LEE J, Chang CL, Lin JB, Wu MH, et al
    Skeletal Muscle Loss is an Imaging Biomarker of Outcome After Definitive Chemoradiotherapy for Locally Advanced Cervical Cancer.
    Clin Cancer Res. 2018 Jun 29. pii: 1078-0432.CCR-18-0788.
    PubMed     Text format     Abstract available


  21. BONAZZOLI E, Predolini F, Cocco E, Bellone S, et al
    Inhibition of BET bromodomain proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a biologically aggressive variant of Endometrial Cancer.
    Clin Cancer Res. 2018 Jun 25. pii: 1078-0432.CCR-18-0864.
    PubMed     Text format     Abstract available


  22. KONSTANTINOPOULOS PA, Matulonis UA
    PARP inhibitors in ovarian cancer: a trailblazing and transformative journey.
    Clin Cancer Res. 2018 Jun 5. pii: 1078-0432.CCR-18-1314.
    PubMed     Text format     Abstract available


  23. TUMIATI M, Hietanen S, Hynninen J, Pietila E, et al
    A functional homologous recombination assay predicts primary chemotherapy response and long-term survival in ovarian cancer patients.
    Clin Cancer Res. 2018 Jun 1. pii: 1078-0432.CCR-17-3770.
    PubMed     Text format     Abstract available


    May 2018
  24. DENIGER DC, Pasetto A, Robbins PF, Gartner JJ, et al
    T-cell responses to TP53 "hotspot" mutations and unique neoantigens expressed by human ovarian cancers.
    Clin Cancer Res. 2018 May 31. pii: 1078-0432.CCR-18-0573.
    PubMed     Text format     Abstract available


  25. GRISHAM R, Moore KN, Gordon MS, Harb W, et al
    Phase Ib Study of Binimetinib with Paclitaxel in Patients with Platinum-Resistant Ovarian Cancer: Final Results, Potential Biomarkers, and Extreme Responders.
    Clin Cancer Res. 2018 May 29. pii: 1078-0432.CCR-18-0494.
    PubMed     Text format     Abstract available


  26. UUSI-KERTTULA H, Davies JA, Thompson J, Wongthida P, et al
    Ad5NULL-A20 - a tropism-modified, alphavbeta6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies.
    Clin Cancer Res. 2018 May 24. pii: 1078-0432.CCR-18-1089.
    PubMed     Text format     Abstract available


  27. SASANO T, Mabuchi S, Kozasa K, Kuroda H, et al
    The highly metastatic nature of uterine cervical/endometrial cancer displaying tumor-related leukocytosis: clinical and preclinical investigations.
    Clin Cancer Res. 2018 May 11. pii: 1078-0432.CCR-17-2472.
    PubMed     Text format     Abstract available


  28. MATSUDA T, Leisegang M, Park JH, Ren L, et al
    Induction of Neoantigen-specific Cytotoxic T Cells and Construction of T-cell Receptor-engineered T cells for Ovarian Cancer.
    Clin Cancer Res. 2018 May 2. pii: 1078-0432.CCR-18-0142.
    PubMed     Text format     Abstract available


    April 2018
  29. CAUMANNS JJ, Berns K, Wisman GBA, Fehrmann RSN, et al
    Integrative kinome profiling identifies mTORC1/2 inhibition as treatment strategy in ovarian clear cell carcinoma.
    Clin Cancer Res. 2018 Apr 23. pii: 1078-0432.CCR-17-3060.
    PubMed     Text format     Abstract available


  30. DI LJ, Hao D, Liu J, Chen M, et al
    Immunogenomic analyses of advanced serous ovarian cancer reveal immune score is a strong prognostic factor and an indicator of chemo-sensitivity.
    Clin Cancer Res. 2018 Apr 16. pii: 1078-0432.CCR-17-3862.
    PubMed     Text format     Abstract available


  31. BELUR NAGARAJ A, Kovalenko O, Avelar RA, Joseph P, et al
    Mitotic Exit dysfunction through the deregulation of APC/C characterizes cisplatin resistant state in epithelial ovarian cancer.
    Clin Cancer Res. 2018 Apr 13. pii: 1078-0432.CCR-17-2885.
    PubMed     Text format     Abstract available


  32. ISON G, Howie LJ, Amiri-Kordestani L, Zhang L, et al
    FDA Approval Summary: Niraparib for the maintenance treatment of patients with recurrent ovarian cancer in response to platinum-based chemotherapy.
    Clin Cancer Res. 2018 Apr 12. pii: 1078-0432.CCR-18-0042.
    PubMed     Text format     Abstract available


  33. PULLIAM N, Fang F, Ozes AR, Tang J, et al
    An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations.
    Clin Cancer Res. 2018 Apr 3. pii: 1078-0432.CCR-18-0204.
    PubMed     Text format     Abstract available


    March 2018
  34. ZHU H, Gu X, Xia L, Zhou Y, et al
    A Novel TGF-beta Trap Blocks Chemotherapeutics-Induced TGF-beta1 Signaling and Enhances Their Anticancer Activity in Gynecological Cancers.
    Clin Cancer Res. 2018 Mar 16. pii: 1078-0432.CCR-17-3112.
    PubMed     Text format     Abstract available


  35. KALLI KR, Block MS, Kasi PM, Erskine CL, et al
    Folate Receptor Alpha Peptide Vaccine generates immunity in Breast and Ovarian Cancer Patients.
    Clin Cancer Res. 2018 Mar 15. pii: 1078-0432.CCR-17-2499.
    PubMed     Text format     Abstract available


  36. MATEI D, Ghamande S, Roman LD, Alvarez Secord A, et al
    A Phase 1 Clinical Trial of Guadecitabine and Carboplatin In Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic And Pharmacodynamic Analyses.
    Clin Cancer Res. 2018 Mar 2. pii: 1078-0432.CCR-17-3055.
    PubMed     Text format     Abstract available


    February 2018
  37. HUANG YF, Wu YH, Cheng WF, Peng SL, et al
    Vitamin D-Binding Protein Enhances Epithelial Ovarian Cancer Progression by Regulating the Insulin-like Growth Factor-1/Akt Pathway and Vitamin D Receptor Transcription.
    Clin Cancer Res. 2018 Feb 23. pii: 1078-0432.CCR-17-2943.
    PubMed     Text format     Abstract available


  38. LANG JD, Hendricks WPD, Orlando KA, Yin H, et al
    Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition.
    Clin Cancer Res. 2018 Feb 9. pii: 1078-0432.CCR-17-1928.
    PubMed     Text format     Abstract available


  39. SHAH A, Bloomquist E, Tang S, Fu W, et al
    FDA Approval: Ribociclib for the Treatment of Postmenopausal Women with Hormone Receptor-Positive, HER2-Negative Advanced or Metastatic Breast Cancer.
    Clin Cancer Res. 2018 Feb 7. pii: 1078-0432.CCR-17-2369.
    PubMed     Text format     Abstract available


    January 2018
  40. BELLONE S, Buza N, Choi J, Zammataro L, et al
    Exceptional response to pembrolizumab in a metastatic, chemotherapy/radiation resistant ovarian cancer patient harboring a CD274/PD-L1-genetic rearrangement.
    Clin Cancer Res. 2018 Jan 19. pii: 1078-0432.CCR-17-1805.
    PubMed     Text format     Abstract available


  41. HARDWICK NR, Frankel P, Ruel C, Kilpatrick J, et al
    p53-reactive T cells are associated with clinical benefit in patients with platinum-resistant epithelial ovarian cancer after treatment with a p53 vaccine and gemcitabine chemotherapy.
    Clin Cancer Res. 2018 Jan 4. pii: 1078-0432.CCR-17-2709.
    PubMed     Text format     Abstract available


    December 2017
  42. TUCKER DW, Getchell CR, McCarthy ET, Ohman AW, et al
    Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer.
    Clin Cancer Res. 2017 Dec 20. pii: 1078-0432.CCR-17-1958.
    PubMed     Text format     Abstract available


    November 2017
  43. NORQUIST BM, Brady MF, Harrell MI, Walsh T, et al
    Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: an NRG Oncology/Gynecologic Oncology Group Study.
    Clin Cancer Res. 2017 Nov 30. pii: 1078-0432.CCR-17-1327.
    PubMed     Text format     Abstract available


  44. PENG G, Mills GB
    Surviving ovarian cancer: an affair between defective DNA repair and RB1.
    Clin Cancer Res. 2017 Nov 30. pii: 1078-0432.CCR-17-3022.
    PubMed     Text format     Abstract available


    October 2017
  45. LABIDI-GALY SI, Olivier T, Rodrigues M, Ferraioli D, et al
    Location of mutation in BRCA2 gene and survival in patients with ovarian cancer.
    Clin Cancer Res. 2017 Oct 30. pii: clincanres.2136.2017.
    PubMed     Text format     Abstract available


  46. BANERJI U, Dean E, Perez-Fidalgo JA, Batist G, et al
    A Phase 1 open-label study to identify a dosing regimen of the pan-AKT inhibitor AZD5363 for evaluation in solid tumors and in PIK3CA-mutated breast and gynecologic cancers.
    Clin Cancer Res. 2017 Oct 24. pii: clincanres.2260.2017.
    PubMed     Text format     Abstract available


  47. GARSED DW, Alsop K, Fereday S, Emmanuel C, et al
    Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer.
    Clin Cancer Res. 2017 Oct 23. pii: clincanres.1621.2017.
    PubMed     Text format     Abstract available


  48. KREUZINGER C, Geroldinger A, Smeets D, Braicu EI, et al
    A complex network of tumor microenvironment in human high grade serous ovarian cancer.
    Clin Cancer Res. 2017 Oct 2. pii: clincanres.1159.2017.
    PubMed     Text format     Abstract available


    September 2017
  49. COOKE SL, Ennis D, Evers L, Dowson S, et al
    The driver mutational landscape of ovarian squamous cell carcinomas arising in mature cystic teratoma.
    Clin Cancer Res. 2017 Sep 27. pii: clincanres.1789.2017.
    PubMed     Text format     Abstract available


  50. HAO D, Li J, Jia S, Meng Y, et al
    Integrated analysis reveals tubal and ovarian originated serous ovarian cancer and predicts differential therapeutic responses.
    Clin Cancer Res. 2017 Sep 22. pii: clincanres.0638.2017.
    PubMed     Text format     Abstract available


  51. DEPREEUW J, Stelloo E, Osse EM, Creutzberg CL, et al
    Amplification of 1q32.1 refines the molecular classification of endometrial carcinoma.
    Clin Cancer Res. 2017 Sep 22. pii: clincanres.0566.2017.
    PubMed     Text format     Abstract available


  52. TRABOULSI W, Sergent F, Boufettal H, Brouillet S, et al
    Antagonism of EG-VEGF receptors as targeted therapy for choriocarcinoma progression in vitro and in vivo.
    Clin Cancer Res. 2017 Sep 12. pii: clincanres.0811.2017.
    PubMed     Text format     Abstract available


  53. KANG Z, Stevanovic S, Hinrichs CS, Cao L, et al
    Circulating Cell-free DNA for Metastatic Cervical Cancer Detection, Genotyping and Monitoring.
    Clin Cancer Res. 2017 Sep 12. pii: clincanres.1553.2017.
    PubMed     Text format     Abstract available


    March 2017
  54. LEE JM, Peer CJ, Yu M, Amable L, et al
    Sequence-Specific Pharmacokinetic and Pharmacodynamic Phase I/Ib Study of Olaparib Tablets and Carboplatin in Women's Cancer.
    Clin Cancer Res. 2017;23:1397-1406.
    PubMed     Text format     Abstract available


  55. APELLANIZ-RUIZ M, Tejero H, Inglada-Perez L, Sanchez-Barroso L, et al
    Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.
    Clin Cancer Res. 2017;23:1227-1235.
    PubMed     Text format     Abstract available


    April 2016
  56. TIPER IV, Temkin SM, Spiegel S, Goldblum SE, et al
    VEGF potentiates GD3-mediated immune suppression by human ovarian cancer cells.
    Clin Cancer Res. 2016 Apr 13. pii: clincanres.2518.2015.
    PubMed     Text format     Abstract available


  57. TERRY KL, Schock H, Fortner RT, Husing A, et al
    A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort.
    Clin Cancer Res. 2016 Apr 8. pii: clincanres.0316.2016.
    PubMed     Text format     Abstract available


    March 2016
  58. FJELDBO CS, Julin CH, Lando M, Forsberg MF, et al
    Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer.
    Clin Cancer Res. 2016 Mar 24. pii: clincanres.2322.2015.
    PubMed     Text format     Abstract available


  59. DAS BC, Tyagi A, Vishnoi K, Mahata S, et al
    Cervical cancer stem cells selectively overexpress HPV oncoprotein E6 that controls stemness and self renewal through upregulation of HES1.
    Clin Cancer Res. 2016 Mar 17. pii: clincanres.2574.2015.
    PubMed     Text format     Abstract available


    January 2016
  60. BONITO NA, Borely J, Wilhelm-Benartzi C, Ghaem-Maghami S, et al
    Epigenetic regulation of the homeobox gene MSX1 associates with platinum resistant disease in high grade serous epithelial ovarian cancer.
    Clin Cancer Res. 2016 Jan 13. pii: clincanres.1669.2015.
    PubMed     Text format     Abstract available


  61. KROEGER DR, Milne K, Nelson BH
    Tumor infiltrating plasma cells are associated with tertiary lymphoid structures, cytolytic T cell responses, and superior prognosis in ovarian cancer.
    Clin Cancer Res. 2016 Jan 13. pii: clincanres.2762.2015.
    PubMed     Text format     Abstract available


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